Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.012 0.09 -9999.0 0.0 -0.281 12.0 12.0 epithelial cell differentiation 0.01 0.102 -9999.0 0.0 -0.345 11.0 11.0 CYFIP2 -0.016 0.145 -9999.0 0.0 -0.636 8.0 8.0 ENAH 0.022 0.126 -9999.0 0.0 -0.439 4.0 4.0 EGFR -0.012 0.13 -9999.0 0.0 -0.563 8.0 8.0 EPHA2 -0.018 0.137 -9999.0 0.0 -0.534 10.0 10.0 MYO6 0.009 0.113 -9999.0 0.0 -0.537 1.0 1.0 CTNNB1 0.003 0.093 -9999.0 0.0 -0.563 4.0 4.0 ABI1/Sra1/Nap1 -0.0 0.12 -9999.0 0.0 -0.419 9.0 9.0 AQP5 -0.044 0.101 -9999.0 0.0 -0.461 3.0 3.0 CTNND1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.02 0.097 -9999.0 0.0 -0.527 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.051 0.16 -9999.0 0.0 -0.349 21.0 21.0 EGF -0.214 0.28 -9999.0 0.0 -0.543 64.0 64.0 NCKAP1 -0.006 0.11 -9999.0 0.0 -0.511 7.0 7.0 AQP3 -0.072 0.16 -9999.0 0.0 -0.559 11.0 11.0 cortical microtubule organization 0.01 0.102 -9999.0 0.0 -0.345 11.0 11.0 GO:0000145 0.018 0.093 -9999.0 0.0 -0.502 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.013 0.104 -9999.0 0.0 -0.349 11.0 11.0 MLLT4 -0.003 0.116 -9999.0 0.0 -0.636 5.0 5.0 ARF6/GDP -0.048 0.122 -9999.0 0.0 -0.566 5.0 5.0 ARF6 0.001 0.104 -9999.0 0.0 -0.636 4.0 4.0 Ephrin A1/EPHA2/NCK1/GIT1 0.01 0.117 -9999.0 0.0 -0.41 8.0 8.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.025 0.101 -9999.0 0.0 -0.49 1.0 1.0 PVRL2 0.01 0.066 -9999.0 0.0 -0.563 2.0 2.0 ZYX 0.018 0.102 -9999.0 0.0 -0.537 1.0 1.0 ARF6/GTP 0.008 0.127 -9999.0 0.0 -0.588 3.0 3.0 CDH1 -0.02 0.153 -9999.0 0.0 -0.636 9.0 9.0 EGFR/EGFR/EGF/EGF -0.131 0.159 -9999.0 0.0 -0.554 9.0 9.0 RhoA/GDP -0.024 0.085 -9999.0 0.0 -0.53 1.0 1.0 actin cytoskeleton organization 0.015 0.109 -9999.0 0.0 -0.503 1.0 1.0 IGF-1R heterotetramer 0.01 0.066 -9999.0 0.0 -0.562 2.0 2.0 GIT1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.01 0.066 -9999.0 0.0 -0.563 2.0 2.0 IGF1 -0.02 0.138 -9999.0 0.0 -0.517 11.0 11.0 DIAPH1 -0.039 0.153 -9999.0 0.0 -0.64 9.0 9.0 Wnt receptor signaling pathway -0.01 0.102 0.345 11.0 -9999.0 0.0 11.0 RHOA 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.042 0.114 -9999.0 0.0 -0.576 4.0 4.0 CTNNA1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.015 0.112 -9999.0 0.0 -0.518 1.0 1.0 EFNA1 0.003 0.093 -9999.0 0.0 -0.563 4.0 4.0 LPP 0.026 0.098 -9999.0 0.0 -0.504 1.0 1.0 Ephrin A1/EPHA2 -0.044 0.131 -9999.0 0.0 -0.673 4.0 4.0 SEC6/SEC8 -0.033 0.11 -9999.0 0.0 -0.539 5.0 5.0 MGAT3 -0.052 0.163 -9999.0 0.0 -0.355 21.0 21.0 HGF/MET -0.035 0.095 -9999.0 0.0 -0.514 1.0 1.0 HGF 0.014 0.052 -9999.0 0.0 -0.636 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.012 0.091 -9999.0 0.0 -0.283 12.0 12.0 actin cable formation 0.039 0.118 -9999.0 0.0 -0.357 4.0 4.0 KIAA1543 0.02 0.122 -9999.0 0.0 -0.711 2.0 2.0 KIFC3 0.016 0.104 -9999.0 0.0 -0.422 2.0 2.0 NCK1 0.005 0.09 -9999.0 0.0 -0.636 3.0 3.0 EXOC3 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.02 0.099 -9999.0 0.0 -0.537 1.0 1.0 NCK1/GIT1 0.017 0.068 -9999.0 0.0 -0.464 3.0 3.0 mol:GDP 0.01 0.102 -9999.0 0.0 -0.345 11.0 11.0 EXOC4 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.018 0.102 -9999.0 0.0 -0.537 1.0 1.0 PIP5K1C 0.02 0.099 -9999.0 0.0 -0.537 1.0 1.0 LIMA1 0.007 0.077 -9999.0 0.0 -0.539 3.0 3.0 ABI1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.03 0.122 -9999.0 0.0 -0.484 4.0 4.0 adherens junction assembly 0.034 0.124 -9999.0 0.0 -0.684 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.041 0.102 -9999.0 0.0 -0.516 2.0 2.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.005 0.099 -9999.0 0.0 -0.447 7.0 7.0 MET -0.006 0.118 -9999.0 0.0 -0.587 6.0 6.0 PLEKHA7 0.02 0.099 -9999.0 0.0 -0.537 1.0 1.0 mol:GTP 0.009 0.116 -9999.0 0.0 -0.407 8.0 8.0 establishment of epithelial cell apical/basal polarity 0.037 0.126 -9999.0 0.0 -0.51 5.0 5.0 cortical actin cytoskeleton stabilization 0.012 0.09 -9999.0 0.0 -0.281 12.0 12.0 regulation of cell-cell adhesion 0.015 0.109 -9999.0 0.0 -0.503 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.012 0.091 -9999.0 0.0 -0.283 12.0 12.0