E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.001 0.152 -9999.0 0.0 -0.548 10.0 10.0 KLHL20 0.039 0.124 0.226 9.0 -0.246 13.0 22.0 CYFIP2 0.012 0.116 -9999.0 0.0 -0.508 7.0 7.0 Rac1/GDP 0.058 0.146 0.338 2.0 -0.424 6.0 8.0 ENAH -0.014 0.162 -9999.0 0.0 -0.571 10.0 10.0 AP1M1 0.038 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.038 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.037 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.07 -9999.0 0.0 -0.369 4.0 4.0 CDC42/GTP 0.04 0.109 -9999.0 0.0 -0.38 5.0 5.0 ABI1/Sra1/Nap1 -0.028 0.059 -9999.0 0.0 -0.178 15.0 15.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.021 0.132 -9999.0 0.0 -0.289 20.0 20.0 RAPGEF1 0.033 0.165 0.351 2.0 -0.501 9.0 11.0 CTNND1 0.038 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.006 0.158 -9999.0 0.0 -0.563 10.0 10.0 CRK 0.029 0.177 -9999.0 0.0 -0.566 9.0 9.0 E-cadherin/gamma catenin/alpha catenin 0.049 0.091 -9999.0 0.0 -0.314 8.0 8.0 alphaE/beta7 Integrin 0.013 0.107 -9999.0 0.0 -0.345 11.0 11.0 IQGAP1 0.035 0.011 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.024 0.069 -9999.0 0.0 -0.27 7.0 7.0 Rap1/GTP/I-afadin 0.06 0.061 -9999.0 0.0 -0.285 4.0 4.0 DLG1 -0.001 0.152 -9999.0 0.0 -0.549 10.0 10.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.011 0.06 -9999.0 0.0 -0.297 4.0 4.0 MLLT4 0.02 0.099 -9999.0 0.0 -0.508 5.0 5.0 ARF6/GTP/NME1/Tiam1 0.052 0.054 -9999.0 0.0 -0.285 2.0 2.0 PI3K -0.011 0.082 -9999.0 0.0 -0.401 4.0 4.0 ARF6 0.03 0.046 -9999.0 0.0 -0.508 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.029 0.098 -9999.0 0.0 -0.369 8.0 8.0 TIAM1 0.034 0.024 -9999.0 0.0 -0.23 1.0 1.0 E-cadherin(dimer)/Ca2+ 0.061 0.095 -9999.0 0.0 -0.279 10.0 10.0 AKT1 0.035 0.073 0.203 2.0 -0.216 4.0 6.0 PIK3R1 0.026 0.077 -9999.0 0.0 -0.508 3.0 3.0 CDH1 0.009 0.124 -9999.0 0.0 -0.508 8.0 8.0 RhoA/GDP 0.073 0.15 0.337 2.0 -0.422 6.0 8.0 actin cytoskeleton organization 0.036 0.096 0.189 10.0 -0.178 13.0 23.0 CDC42/GDP 0.066 0.148 0.337 2.0 -0.422 6.0 8.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.015 0.062 -9999.0 0.0 -0.239 8.0 8.0 ITGB7 0.001 0.137 -9999.0 0.0 -0.508 10.0 10.0 RAC1 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.066 0.102 -9999.0 0.0 -0.296 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.042 0.088 -9999.0 0.0 -0.278 10.0 10.0 mol:GDP 0.057 0.164 0.341 2.0 -0.505 6.0 8.0 CDC42/GTP/IQGAP1 0.044 0.019 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.035 0.023 -9999.0 0.0 -0.23 1.0 1.0 p120 catenin/RhoA/GDP 0.084 0.155 0.345 2.0 -0.433 6.0 8.0 RAC1/GTP/IQGAP1 0.042 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.055 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.038 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.036 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.038 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.032 0.074 0.152 12.0 -0.239 1.0 13.0 NME1 0.033 0.045 -9999.0 0.0 -0.508 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.003 0.15 -9999.0 0.0 -0.548 10.0 10.0 regulation of cell-cell adhesion -0.002 0.074 -9999.0 0.0 -0.328 5.0 5.0 WASF2 0.016 0.057 0.111 9.0 -0.164 2.0 11.0 Rap1/GTP 0.083 0.137 0.328 2.0 -0.435 5.0 7.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.035 0.125 -9999.0 0.0 -0.267 18.0 18.0 CCND1 0.035 0.087 0.177 11.0 -0.227 2.0 13.0 VAV2 0.009 0.297 -9999.0 0.0 -0.712 18.0 18.0 RAP1/GDP 0.087 0.146 0.349 2.0 -0.443 5.0 7.0 adherens junction assembly -0.002 0.144 -9999.0 0.0 -0.528 10.0 10.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.038 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.037 0.008 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.022 0.121 -9999.0 0.0 -0.267 15.0 15.0 E-cadherin/beta catenin -0.002 0.088 -9999.0 0.0 -0.363 8.0 8.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.022 0.158 -9999.0 0.0 -0.607 9.0 9.0 PIK3CA 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.055 0.129 -9999.0 0.0 -0.38 18.0 18.0 E-cadherin/beta catenin/alpha catenin 0.047 0.103 -9999.0 0.0 -0.325 10.0 10.0 ITGAE 0.027 0.027 -9999.0 0.0 -0.23 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.005 0.162 -9999.0 0.0 -0.578 10.0 10.0