Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.012 0.07 -9999.0 0.0 -0.245 10.0 10.0 epithelial cell differentiation 0.054 0.092 -9999.0 0.0 -0.276 10.0 10.0 CYFIP2 0.012 0.116 -9999.0 0.0 -0.508 7.0 7.0 ENAH -0.038 0.079 -9999.0 0.0 -0.354 4.0 4.0 EGFR 0.018 0.091 -9999.0 0.0 -0.452 5.0 5.0 EPHA2 0.019 0.072 -9999.0 0.0 -0.265 8.0 8.0 MYO6 -0.006 0.086 -9999.0 0.0 -0.265 14.0 14.0 CTNNB1 0.027 0.07 -9999.0 0.0 -0.369 4.0 4.0 ABI1/Sra1/Nap1 0.046 0.098 -9999.0 0.0 -0.327 8.0 8.0 AQP5 -0.015 0.08 -9999.0 0.0 -0.398 2.0 2.0 CTNND1 0.038 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.002 0.074 -9999.0 0.0 -0.263 10.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.04 0.109 -9999.0 0.0 -0.267 24.0 24.0 EGF -0.109 0.203 -9999.0 0.0 -0.342 57.0 57.0 NCKAP1 0.024 0.069 -9999.0 0.0 -0.27 7.0 7.0 AQP3 -0.035 0.137 -9999.0 0.0 -0.584 6.0 6.0 cortical microtubule organization 0.054 0.092 -9999.0 0.0 -0.276 10.0 10.0 GO:0000145 -0.022 0.064 -9999.0 0.0 -0.251 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.061 0.095 -9999.0 0.0 -0.279 10.0 10.0 MLLT4 0.02 0.099 -9999.0 0.0 -0.508 5.0 5.0 ARF6/GDP -0.041 0.088 -9999.0 0.0 -0.391 5.0 5.0 ARF6 0.03 0.046 -9999.0 0.0 -0.508 1.0 1.0 Ephrin A1/EPHA2/NCK1/GIT1 0.057 0.095 -9999.0 0.0 -0.319 6.0 6.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.008 0.071 -9999.0 0.0 -0.293 2.0 2.0 PVRL2 0.033 0.05 -9999.0 0.0 -0.369 2.0 2.0 ZYX 0.002 0.075 -9999.0 0.0 -0.265 10.0 10.0 ARF6/GTP 0.056 0.102 -9999.0 0.0 -0.305 7.0 7.0 CDH1 0.009 0.124 -9999.0 0.0 -0.508 8.0 8.0 EGFR/EGFR/EGF/EGF -0.044 0.143 -9999.0 0.0 -0.282 30.0 30.0 RhoA/GDP 0.057 0.09 -9999.0 0.0 -0.264 10.0 10.0 actin cytoskeleton organization -0.013 0.08 -9999.0 0.0 -0.337 1.0 1.0 IGF-1R heterotetramer 0.03 0.05 -9999.0 0.0 -0.368 2.0 2.0 GIT1 0.036 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.03 0.05 -9999.0 0.0 -0.369 2.0 2.0 IGF1 0.016 0.086 -9999.0 0.0 -0.285 10.0 10.0 DIAPH1 0.022 0.198 -9999.0 0.0 -0.645 10.0 10.0 Wnt receptor signaling pathway -0.054 0.092 0.276 10.0 -9999.0 0.0 10.0 RHOA 0.038 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.04 0.087 -9999.0 0.0 -0.416 4.0 4.0 CTNNA1 0.038 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.014 0.082 -9999.0 0.0 -0.345 1.0 1.0 EFNA1 0.029 0.067 -9999.0 0.0 -0.415 3.0 3.0 LPP -0.008 0.065 -9999.0 0.0 -0.333 1.0 1.0 Ephrin A1/EPHA2 0.031 0.115 -9999.0 0.0 -0.456 4.0 4.0 SEC6/SEC8 -0.007 0.095 -9999.0 0.0 -0.404 5.0 5.0 MGAT3 -0.041 0.11 -9999.0 0.0 -0.27 24.0 24.0 HGF/MET 0.038 0.096 -9999.0 0.0 -0.27 5.0 5.0 HGF 0.037 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.012 0.071 -9999.0 0.0 -0.247 10.0 10.0 actin cable formation -0.021 0.094 -9999.0 0.0 -0.321 4.0 4.0 KIAA1543 -0.012 0.088 -9999.0 0.0 -0.526 2.0 2.0 KIFC3 -0.001 0.077 -9999.0 0.0 -0.266 11.0 11.0 NCK1 0.027 0.077 -9999.0 0.0 -0.508 3.0 3.0 EXOC3 0.039 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.001 0.073 -9999.0 0.0 -0.266 10.0 10.0 NCK1/GIT1 0.044 0.061 -9999.0 0.0 -0.369 3.0 3.0 mol:GDP 0.054 0.092 -9999.0 0.0 -0.276 10.0 10.0 EXOC4 0.037 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.024 0.066 -9999.0 0.0 -0.265 10.0 10.0 PIP5K1C 0.002 0.075 -9999.0 0.0 -0.266 10.0 10.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.038 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.017 0.085 -9999.0 0.0 -0.449 2.0 2.0 adherens junction assembly -0.01 0.1 -9999.0 0.0 -0.526 2.0 2.0 IGF-1R heterotetramer/IGF1 0.027 0.103 -9999.0 0.0 -0.339 2.0 2.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.085 -9999.0 0.0 -0.369 6.0 6.0 MET 0.019 0.093 -9999.0 0.0 -0.415 6.0 6.0 PLEKHA7 0.003 0.075 -9999.0 0.0 -0.266 10.0 10.0 mol:GTP 0.055 0.094 -9999.0 0.0 -0.317 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.027 0.09 -9999.0 0.0 -0.389 5.0 5.0 cortical actin cytoskeleton stabilization 0.012 0.07 -9999.0 0.0 -0.245 10.0 10.0 regulation of cell-cell adhesion -0.013 0.08 -9999.0 0.0 -0.337 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.012 0.071 -9999.0 0.0 -0.247 10.0 10.0