E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.008 0.149 -9999.0 0.0 -0.513 16.0 16.0 KLHL20 0.032 0.119 0.219 11.0 -0.242 21.0 32.0 CYFIP2 0.012 0.11 -9999.0 0.0 -0.456 11.0 11.0 Rac1/GDP 0.054 0.14 0.297 6.0 -0.404 8.0 14.0 ENAH -0.019 0.155 -9999.0 0.0 -0.527 16.0 16.0 AP1M1 0.035 0.035 -9999.0 0.0 -0.48 1.0 1.0 RAP1B 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.092 -9999.0 0.0 -0.301 15.0 15.0 CDC42/GTP 0.037 0.1 -9999.0 0.0 -0.361 6.0 6.0 ABI1/Sra1/Nap1 -0.027 0.058 -9999.0 0.0 -0.175 23.0 23.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.016 0.126 -9999.0 0.0 -0.27 29.0 29.0 RAPGEF1 0.036 0.156 0.319 3.0 -0.492 11.0 14.0 CTNND1 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.001 0.154 -9999.0 0.0 -0.526 16.0 16.0 CRK 0.032 0.164 -9999.0 0.0 -0.55 11.0 11.0 E-cadherin/gamma catenin/alpha catenin 0.052 0.08 -9999.0 0.0 -0.296 10.0 10.0 alphaE/beta7 Integrin 0.015 0.099 -9999.0 0.0 -0.33 15.0 15.0 IQGAP1 0.035 0.009 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.023 0.067 -9999.0 0.0 -0.265 10.0 10.0 Rap1/GTP/I-afadin 0.057 0.056 -9999.0 0.0 -0.268 5.0 5.0 DLG1 -0.009 0.149 -9999.0 0.0 -0.514 16.0 16.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.01 0.054 -9999.0 0.0 -0.265 6.0 6.0 MLLT4 0.022 0.085 -9999.0 0.0 -0.48 6.0 6.0 ARF6/GTP/NME1/Tiam1 0.05 0.06 -9999.0 0.0 -0.28 5.0 5.0 PI3K -0.01 0.073 -9999.0 0.0 -0.353 6.0 6.0 ARF6 0.029 0.05 -9999.0 0.0 -0.48 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.033 0.085 -9999.0 0.0 -0.328 11.0 11.0 TIAM1 0.029 0.053 -9999.0 0.0 -0.39 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.052 0.095 -9999.0 0.0 -0.259 15.0 15.0 AKT1 0.033 0.069 0.182 4.0 -0.206 5.0 9.0 PIK3R1 0.029 0.061 -9999.0 0.0 -0.48 3.0 3.0 CDH1 0.013 0.108 -9999.0 0.0 -0.48 10.0 10.0 RhoA/GDP 0.067 0.142 0.29 5.0 -0.402 8.0 13.0 actin cytoskeleton organization 0.032 0.094 0.19 14.0 -0.179 18.0 32.0 CDC42/GDP 0.061 0.142 0.296 6.0 -0.402 8.0 14.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.016 0.055 -9999.0 0.0 -0.232 10.0 10.0 ITGB7 0.003 0.127 -9999.0 0.0 -0.48 14.0 14.0 RAC1 0.033 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.056 0.102 -9999.0 0.0 -0.275 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.034 0.087 -9999.0 0.0 -0.257 15.0 15.0 mol:GDP 0.053 0.156 0.298 6.0 -0.431 11.0 17.0 CDC42/GTP/IQGAP1 0.043 0.02 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.035 0.018 -9999.0 0.0 -0.211 1.0 1.0 p120 catenin/RhoA/GDP 0.077 0.148 0.306 4.0 -0.413 8.0 12.0 RAC1/GTP/IQGAP1 0.041 0.019 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.052 0.029 -9999.0 0.0 -0.347 1.0 1.0 RHOA 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.033 0.019 -9999.0 0.0 -0.211 1.0 1.0 CTNNA1 0.036 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.029 0.074 0.153 17.0 -0.192 5.0 22.0 NME1 0.033 0.036 -9999.0 0.0 -0.48 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.009 0.147 -9999.0 0.0 -0.514 16.0 16.0 regulation of cell-cell adhesion -0.001 0.068 -9999.0 0.0 -0.299 7.0 7.0 WASF2 0.014 0.053 0.109 12.0 -0.139 4.0 16.0 Rap1/GTP 0.075 0.127 0.3 3.0 -0.392 7.0 10.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.039 0.116 -9999.0 0.0 -0.253 24.0 24.0 CCND1 0.032 0.088 0.174 17.0 -0.239 5.0 22.0 VAV2 0.008 0.285 -9999.0 0.0 -0.672 27.0 27.0 RAP1/GDP 0.08 0.138 0.326 4.0 -0.408 7.0 11.0 adherens junction assembly -0.008 0.143 -9999.0 0.0 -0.495 16.0 16.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.017 0.117 -9999.0 0.0 -0.248 28.0 28.0 E-cadherin/beta catenin -0.003 0.079 -9999.0 0.0 -0.335 11.0 11.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.021 0.143 -9999.0 0.0 -0.59 11.0 11.0 PIK3CA 0.036 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.044 0.134 -9999.0 0.0 -0.396 23.0 23.0 E-cadherin/beta catenin/alpha catenin 0.038 0.102 -9999.0 0.0 -0.302 15.0 15.0 ITGAE 0.026 0.028 -9999.0 0.0 -0.211 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.002 0.158 -9999.0 0.0 -0.54 16.0 16.0