Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.012 0.131 -9999.0 0.0 -0.605 7.0 7.0 IHH 0.026 0.094 -9999.0 0.0 -0.43 7.0 7.0 SHH Np/Cholesterol/GAS1 -0.077 0.141 -9999.0 0.0 -0.306 49.0 49.0 LRPAP1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.076 0.14 0.304 49.0 -9999.0 0.0 49.0 SMO/beta Arrestin2 0.005 0.122 -9999.0 0.0 -0.373 12.0 12.0 SMO -0.009 0.117 -9999.0 0.0 -0.393 12.0 12.0 AKT1 -0.02 0.156 -9999.0 0.0 -0.526 11.0 11.0 ARRB2 0.026 0.038 -9999.0 0.0 -0.48 1.0 1.0 BOC 0.027 0.056 -9999.0 0.0 -0.245 8.0 8.0 ADRBK1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.009 0.116 -9999.0 0.0 -0.334 21.0 21.0 STIL -0.004 0.111 0.352 2.0 -0.301 9.0 11.0 DHH N/PTCH2 0.053 0.011 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.027 0.08 -9999.0 0.0 -0.304 10.0 10.0 PIK3CA 0.036 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.001 0.183 -9999.0 0.0 -0.912 7.0 7.0 determination of left/right symmetry -0.009 0.116 -9999.0 0.0 -0.334 21.0 21.0 PIK3R1 0.029 0.061 -9999.0 0.0 -0.48 3.0 3.0 skeletal system development -0.001 0.181 -9999.0 0.0 -0.899 7.0 7.0 IHH N/Hhip -0.015 0.161 -9999.0 0.0 -0.393 30.0 30.0 DHH N/Hhip -0.005 0.134 -9999.0 0.0 -0.347 26.0 26.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.009 0.116 -9999.0 0.0 -0.334 21.0 21.0 pancreas development -0.037 0.171 -9999.0 0.0 -0.405 36.0 36.0 HHAT -0.005 0.135 -9999.0 0.0 -0.413 20.0 20.0 PI3K 0.047 0.048 -9999.0 0.0 -0.347 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.122 0.203 -9999.0 0.0 -0.333 93.0 93.0 somite specification -0.009 0.116 -9999.0 0.0 -0.334 21.0 21.0 SHH Np/Cholesterol/PTCH1 -0.008 0.096 -9999.0 0.0 -0.252 26.0 26.0 SHH Np/Cholesterol/PTCH2 0.009 0.084 -9999.0 0.0 -0.273 16.0 16.0 SHH Np/Cholesterol/Megalin 0.008 0.084 -9999.0 0.0 -0.273 16.0 16.0 SHH -0.013 0.1 -9999.0 0.0 -0.354 16.0 16.0 catabolic process 0.006 0.083 -9999.0 0.0 -0.341 10.0 10.0 SMO/Vitamin D3 -0.019 0.112 -9999.0 0.0 -0.331 15.0 15.0 SHH Np/Cholesterol/Hhip -0.033 0.132 -9999.0 0.0 -0.302 37.0 37.0 LRP2 0.035 0.024 -9999.0 0.0 -0.211 2.0 2.0 receptor-mediated endocytosis -0.018 0.109 -9999.0 0.0 -0.323 15.0 15.0 SHH Np/Cholesterol/BOC 0.004 0.086 -9999.0 0.0 -0.273 16.0 16.0 SHH Np/Cholesterol/CDO 0.007 0.084 -9999.0 0.0 -0.273 16.0 16.0 mesenchymal cell differentiation 0.033 0.132 0.3 37.0 -9999.0 0.0 37.0 mol:Vitamin D3 0.002 0.109 0.363 2.0 -0.252 26.0 28.0 IHH N/PTCH2 0.046 0.062 -9999.0 0.0 -0.316 5.0 5.0 CDON 0.034 0.024 -9999.0 0.0 -0.211 2.0 2.0 IHH N/PTCH1 0.026 0.089 -9999.0 0.0 -0.343 10.0 10.0 Megalin/LRPAP1 0.051 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.004 0.079 -9999.0 0.0 -0.271 16.0 16.0 PTCH1 0.006 0.083 -9999.0 0.0 -0.342 10.0 10.0 HHIP -0.037 0.172 -9999.0 0.0 -0.405 36.0 36.0