Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.007 0.07 -9999.0 0.0 -0.241 15.0 15.0 epithelial cell differentiation 0.045 0.092 -9999.0 0.0 -0.256 15.0 15.0 CYFIP2 0.012 0.11 -9999.0 0.0 -0.456 11.0 11.0 ENAH -0.042 0.08 -9999.0 0.0 -0.354 5.0 5.0 EGFR 0.016 0.088 -9999.0 0.0 -0.413 8.0 8.0 EPHA2 0.012 0.087 -9999.0 0.0 -0.283 15.0 15.0 MYO6 -0.008 0.08 -9999.0 0.0 -0.248 18.0 18.0 CTNNB1 0.014 0.092 -9999.0 0.0 -0.301 15.0 15.0 ABI1/Sra1/Nap1 0.047 0.088 -9999.0 0.0 -0.305 10.0 10.0 AQP5 -0.021 0.091 -9999.0 0.0 -0.471 4.0 4.0 CTNND1 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.003 0.073 -9999.0 0.0 -0.246 14.0 14.0 regulation of calcium-dependent cell-cell adhesion -0.04 0.101 -9999.0 0.0 -0.246 35.0 35.0 EGF -0.094 0.189 -9999.0 0.0 -0.32 79.0 79.0 NCKAP1 0.023 0.067 -9999.0 0.0 -0.265 10.0 10.0 AQP3 -0.035 0.107 -9999.0 0.0 -0.369 15.0 15.0 cortical microtubule organization 0.045 0.092 -9999.0 0.0 -0.256 15.0 15.0 GO:0000145 -0.026 0.063 -9999.0 0.0 -0.305 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.052 0.095 -9999.0 0.0 -0.259 15.0 15.0 MLLT4 0.022 0.085 -9999.0 0.0 -0.48 6.0 6.0 ARF6/GDP -0.049 0.086 -9999.0 0.0 -0.379 7.0 7.0 ARF6 0.029 0.05 -9999.0 0.0 -0.48 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.048 0.097 -9999.0 0.0 -0.278 12.0 12.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.014 0.074 -9999.0 0.0 -0.294 3.0 3.0 PVRL2 0.033 0.042 -9999.0 0.0 -0.301 3.0 3.0 ZYX -0.006 0.077 -9999.0 0.0 -0.248 16.0 16.0 ARF6/GTP 0.048 0.102 -9999.0 0.0 -0.27 13.0 13.0 CDH1 0.013 0.108 -9999.0 0.0 -0.48 10.0 10.0 EGFR/EGFR/EGF/EGF -0.041 0.137 -9999.0 0.0 -0.271 43.0 43.0 RhoA/GDP 0.048 0.09 -9999.0 0.0 -0.245 15.0 15.0 actin cytoskeleton organization -0.03 0.07 -9999.0 0.0 -0.316 1.0 1.0 IGF-1R heterotetramer 0.031 0.04 -9999.0 0.0 -0.345 2.0 2.0 GIT1 0.035 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.031 0.04 -9999.0 0.0 -0.346 2.0 2.0 IGF1 0.016 0.082 -9999.0 0.0 -0.265 15.0 15.0 DIAPH1 0.027 0.183 -9999.0 0.0 -0.612 15.0 15.0 Wnt receptor signaling pathway -0.045 0.092 0.256 15.0 -9999.0 0.0 15.0 RHOA 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.048 0.085 -9999.0 0.0 -0.398 6.0 6.0 CTNNA1 0.036 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.031 0.072 -9999.0 0.0 -0.323 1.0 1.0 EFNA1 0.023 0.075 -9999.0 0.0 -0.365 7.0 7.0 LPP -0.026 0.063 -9999.0 0.0 -0.312 1.0 1.0 Ephrin A1/EPHA2 0.017 0.117 -9999.0 0.0 -0.298 20.0 20.0 SEC6/SEC8 -0.011 0.092 -9999.0 0.0 -0.398 7.0 7.0 MGAT3 -0.04 0.103 -9999.0 0.0 -0.249 35.0 35.0 HGF/MET 0.031 0.096 -9999.0 0.0 -0.263 15.0 15.0 HGF 0.031 0.043 -9999.0 0.0 -0.301 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.007 0.071 -9999.0 0.0 -0.242 15.0 15.0 actin cable formation -0.025 0.09 0.245 1.0 -0.298 8.0 9.0 KIAA1543 -0.033 0.077 -9999.0 0.0 -0.407 3.0 3.0 KIFC3 -0.006 0.077 -9999.0 0.0 -0.248 16.0 16.0 NCK1 0.027 0.07 -9999.0 0.0 -0.48 4.0 4.0 EXOC3 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.004 0.073 -9999.0 0.0 -0.248 15.0 15.0 NCK1/GIT1 0.043 0.056 -9999.0 0.0 -0.347 4.0 4.0 mol:GDP 0.045 0.092 -9999.0 0.0 -0.256 15.0 15.0 EXOC4 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.029 0.062 -9999.0 0.0 -0.246 15.0 15.0 PIP5K1C -0.003 0.074 -9999.0 0.0 -0.249 14.0 14.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.035 0.085 -9999.0 0.0 -0.394 4.0 4.0 adherens junction assembly -0.018 0.089 -9999.0 0.0 -0.466 2.0 2.0 IGF-1R heterotetramer/IGF1 0.022 0.099 -9999.0 0.0 -0.251 18.0 18.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.074 -9999.0 0.0 -0.347 7.0 7.0 MET 0.028 0.055 -9999.0 0.0 -0.346 4.0 4.0 PLEKHA7 -0.003 0.074 -9999.0 0.0 -0.248 15.0 15.0 mol:GTP 0.046 0.095 -9999.0 0.0 -0.276 12.0 12.0 establishment of epithelial cell apical/basal polarity -0.032 0.087 -9999.0 0.0 -0.383 7.0 7.0 cortical actin cytoskeleton stabilization 0.007 0.07 -9999.0 0.0 -0.241 15.0 15.0 regulation of cell-cell adhesion -0.03 0.07 -9999.0 0.0 -0.316 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.007 0.071 -9999.0 0.0 -0.242 15.0 15.0