Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.139 0.194 -9999.0 0.0 -0.496 12.0 12.0 IHH -0.086 0.142 -9999.0 0.0 -0.314 17.0 17.0 SHH Np/Cholesterol/GAS1 0.025 0.049 -9999.0 0.0 -9999.0 0.0 0.0 LRPAP1 0.04 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.024 0.049 -9999.0 0.0 -9999.0 0.0 0.0 SMO/beta Arrestin2 -0.07 0.164 -9999.0 0.0 -0.411 7.0 7.0 SMO -0.089 0.158 -9999.0 0.0 -0.377 12.0 12.0 AKT1 -0.057 0.203 -9999.0 0.0 -0.665 6.0 6.0 ARRB2 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.023 0.087 -9999.0 0.0 -0.482 2.0 2.0 ADRBK1 0.041 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.088 0.156 -9999.0 0.0 -0.372 12.0 12.0 STIL -0.049 0.116 -9999.0 0.0 -0.358 1.0 1.0 DHH N/PTCH2 0.044 0.069 -9999.0 0.0 -0.346 2.0 2.0 DHH N/PTCH1 -0.084 0.122 -9999.0 0.0 -0.277 13.0 13.0 PIK3CA 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.026 0.087 -9999.0 0.0 -0.482 2.0 2.0 PTHLH -0.23 0.354 -9999.0 0.0 -0.993 11.0 11.0 determination of left/right symmetry -0.088 0.156 -9999.0 0.0 -0.372 12.0 12.0 PIK3R1 0.003 0.127 -9999.0 0.0 -0.449 5.0 5.0 skeletal system development -0.227 0.349 -9999.0 0.0 -0.979 11.0 11.0 IHH N/Hhip -0.064 0.142 -9999.0 0.0 -0.299 14.0 14.0 DHH N/Hhip 0.003 0.139 -9999.0 0.0 -0.291 11.0 11.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.088 0.156 -9999.0 0.0 -0.372 12.0 12.0 pancreas development -0.021 0.142 -9999.0 0.0 -0.343 11.0 11.0 HHAT 0.032 0.043 -9999.0 0.0 -0.313 1.0 1.0 PI3K 0.029 0.099 -9999.0 0.0 -0.32 5.0 5.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.025 0.072 -9999.0 0.0 -0.313 3.0 3.0 somite specification -0.088 0.156 -9999.0 0.0 -0.372 12.0 12.0 SHH Np/Cholesterol/PTCH1 -0.068 0.1 -9999.0 0.0 -0.256 9.0 9.0 SHH Np/Cholesterol/PTCH2 0.034 0.029 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin -0.01 0.11 -9999.0 0.0 -0.281 9.0 9.0 SHH 0.018 0.03 -9999.0 0.0 -0.213 1.0 1.0 catabolic process -0.101 0.121 -9999.0 0.0 -0.286 16.0 16.0 SMO/Vitamin D3 -0.074 0.135 -9999.0 0.0 -0.308 12.0 12.0 SHH Np/Cholesterol/Hhip 0.003 0.081 -9999.0 0.0 -0.265 2.0 2.0 LRP2 -0.051 0.196 -9999.0 0.0 -0.482 12.0 12.0 receptor-mediated endocytosis -0.093 0.174 -9999.0 0.0 -0.408 12.0 12.0 SHH Np/Cholesterol/BOC 0.025 0.058 -9999.0 0.0 -0.265 2.0 2.0 SHH Np/Cholesterol/CDO 0.011 0.087 -9999.0 0.0 -0.301 4.0 4.0 mesenchymal cell differentiation -0.003 0.081 0.264 2.0 -9999.0 0.0 2.0 mol:Vitamin D3 -0.052 0.122 -9999.0 0.0 -0.257 9.0 9.0 IHH N/PTCH2 -0.021 0.093 -9999.0 0.0 -0.2 5.0 5.0 CDON -0.017 0.161 -9999.0 0.0 -0.461 8.0 8.0 IHH N/PTCH1 -0.094 0.131 -9999.0 0.0 -0.288 16.0 16.0 Megalin/LRPAP1 -0.01 0.147 -9999.0 0.0 -0.346 11.0 11.0 PTCH2 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.02 0.024 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.101 0.122 -9999.0 0.0 -0.287 16.0 16.0 HHIP -0.021 0.142 -9999.0 0.0 -0.344 11.0 11.0