Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.074 0.133 -9999.0 0.0 -0.24 9.0 9.0 epithelial cell differentiation -0.05 0.138 -9999.0 0.0 -0.224 9.0 9.0 CYFIP2 0.031 0.035 -9999.0 0.0 -0.145 1.0 1.0 ENAH -0.062 0.083 -9999.0 0.0 -0.382 1.0 1.0 EGFR -0.005 0.116 -9999.0 0.0 -0.311 3.0 3.0 EPHA2 0.023 0.036 -9999.0 0.0 -0.145 1.0 1.0 MYO6 -0.074 0.138 0.185 1.0 -0.236 9.0 10.0 CTNNB1 0.004 0.113 -9999.0 0.0 -0.395 2.0 2.0 ABI1/Sra1/Nap1 0.059 0.038 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.057 0.107 -9999.0 0.0 -0.369 1.0 1.0 CTNND1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.056 0.107 0.183 1.0 -0.195 9.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.066 0.115 0.183 1.0 -0.211 9.0 10.0 EGF 0.023 0.048 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.055 0.107 -9999.0 0.0 -0.369 1.0 1.0 cortical microtubule organization -0.05 0.138 -9999.0 0.0 -0.224 9.0 9.0 GO:0000145 -0.066 0.093 0.166 1.0 -0.186 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.047 0.142 -9999.0 0.0 -0.226 9.0 9.0 MLLT4 0.019 0.082 -9999.0 0.0 -0.395 1.0 1.0 ARF6/GDP -0.083 0.091 -9999.0 0.0 -0.298 2.0 2.0 ARF6 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.063 0.055 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.073 0.115 -9999.0 0.0 -0.279 5.0 5.0 PVRL2 0.009 0.081 -9999.0 0.0 -0.395 1.0 1.0 ZYX -0.053 0.119 0.185 1.0 -0.22 8.0 9.0 ARF6/GTP 0.077 0.046 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.131 0.185 -9999.0 0.0 -0.288 14.0 14.0 EGFR/EGFR/EGF/EGF -0.072 0.13 -9999.0 0.0 -0.217 11.0 11.0 RhoA/GDP -0.051 0.153 -9999.0 0.0 -0.234 9.0 9.0 actin cytoskeleton organization -0.076 0.132 0.171 1.0 -0.232 9.0 10.0 IGF-1R heterotetramer 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.022 0.082 -9999.0 0.0 -0.395 1.0 1.0 DIAPH1 0.049 0.107 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.05 0.138 0.224 9.0 -9999.0 0.0 9.0 RHOA 0.02 0.082 -9999.0 0.0 -0.395 1.0 1.0 RhoA/GTP -0.089 0.111 -9999.0 0.0 -0.375 2.0 2.0 CTNNA1 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.078 0.135 0.172 1.0 -0.238 9.0 10.0 EFNA1 0.031 0.035 -9999.0 0.0 -0.145 1.0 1.0 LPP -0.07 0.095 0.175 1.0 -0.211 2.0 3.0 Ephrin A1/EPHA2 -0.058 0.126 -9999.0 0.0 -0.232 6.0 6.0 SEC6/SEC8 -0.068 0.123 -9999.0 0.0 -0.25 6.0 6.0 MGAT3 -0.067 0.117 0.185 1.0 -0.214 9.0 10.0 HGF/MET -0.055 0.129 -9999.0 0.0 -0.217 9.0 9.0 HGF 0.013 0.057 -9999.0 0.0 -0.145 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.074 0.134 -9999.0 0.0 -0.242 9.0 9.0 actin cable formation -0.048 0.077 -9999.0 0.0 -0.249 1.0 1.0 KIAA1543 -0.085 0.105 -9999.0 0.0 -0.211 10.0 10.0 KIFC3 -0.067 0.119 -9999.0 0.0 -0.216 9.0 9.0 NCK1 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.068 0.119 0.185 1.0 -0.216 9.0 10.0 NCK1/GIT1 0.056 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.05 0.138 -9999.0 0.0 -0.224 9.0 9.0 EXOC4 0.032 0.013 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.086 0.099 -9999.0 0.0 -0.215 9.0 9.0 PIP5K1C -0.056 0.108 0.185 1.0 -0.198 9.0 10.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.033 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.079 0.099 -9999.0 0.0 -0.455 1.0 1.0 adherens junction assembly -0.043 0.134 0.297 1.0 -0.392 1.0 2.0 IGF-1R heterotetramer/IGF1 -0.048 0.143 -9999.0 0.0 -0.229 8.0 8.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.008 0.085 -9999.0 0.0 -0.278 2.0 2.0 MET 0.027 0.036 -9999.0 0.0 -0.145 1.0 1.0 PLEKHA7 -0.072 0.11 -9999.0 0.0 -0.216 9.0 9.0 mol:GTP 0.061 0.054 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.057 0.136 0.257 1.0 -0.308 3.0 4.0 cortical actin cytoskeleton stabilization -0.074 0.133 -9999.0 0.0 -0.24 9.0 9.0 regulation of cell-cell adhesion -0.076 0.132 0.171 1.0 -0.232 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.074 0.134 -9999.0 0.0 -0.242 9.0 9.0