Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	6.0	309.0	51.0	-0.902	0.038	1000.0	-1000.0	-0.098	-1000.0
E-cadherin signaling events	6.0	34.0	5.0	-0.131	0.038	1000.0	-1000.0	0.02	-1000.0
Ephrin A  reverse signaling	5.0	37.0	7.0	-0.102	0.006	1000.0	-1000.0	0.0	-1000.0
TCGA08_retinoblastoma	5.0	43.0	8.0	-0.056	0.094	1000.0	-1000.0	-0.005	-1000.0
IL23-mediated signaling events	5.0	301.0	60.0	-0.665	0.039	1000.0	-1000.0	-0.081	-1000.0
Syndecan-1-mediated signaling events	4.0	139.0	34.0	-0.175	0.038	1000.0	-1000.0	-0.023	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	302.0	68.0	-0.509	0.321	1000.0	-1000.0	-0.075	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	331.0	74.0	-0.131	0.077	1000.0	-1000.0	-0.049	-1000.0
IL12-mediated signaling events	3.0	293.0	87.0	-0.399	0.063	1000.0	-1000.0	-0.057	-1000.0
PLK2 and PLK4 events	3.0	9.0	3.0	-0.025	-1000.0	1000.0	-1000.0	0.002	-1000.0
Signaling events mediated by the Hedgehog family	3.0	183.0	52.0	-0.115	0.064	1000.0	-1000.0	-0.024	-1000.0
Thromboxane A2 receptor signaling	3.0	404.0	105.0	-0.252	0.058	1000.0	-1000.0	-0.035	-1000.0
Ephrin B reverse signaling	3.0	165.0	48.0	-0.108	0.045	1000.0	-1000.0	-0.03	-1000.0
Endothelins	3.0	357.0	96.0	-0.332	0.048	1000.0	-1000.0	-0.042	-1000.0
Syndecan-3-mediated signaling events	3.0	110.0	35.0	-0.111	0.069	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	397.0	125.0	-0.11	0.066	1000.0	-1000.0	-0.027	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	277.0	76.0	-0.145	0.059	1000.0	-1000.0	-0.049	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	282.0	136.0	-0.441	0.1	1000.0	-1000.0	-0.035	-1000.0
Visual signal transduction: Cones	2.0	76.0	38.0	-0.058	0.041	1000.0	-1000.0	-0.0	-1000.0
Osteopontin-mediated events	2.0	99.0	38.0	-0.086	0.038	1000.0	-1000.0	-0.028	-1000.0
HIF-1-alpha transcription factor network	2.0	190.0	76.0	-0.21	0.072	1000.0	-1000.0	-0.026	-1000.0
Arf6 signaling events	2.0	159.0	62.0	-0.072	0.079	1000.0	-1000.0	-0.009	-1000.0
PLK1 signaling events	2.0	244.0	85.0	-0.171	0.054	1000.0	-1000.0	-0.042	-1000.0
IL1-mediated signaling events	2.0	126.0	62.0	-0.105	0.076	1000.0	-1000.0	-0.026	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	177.0	82.0	-0.059	0.058	1000.0	-1000.0	-0.04	-1000.0
TCGA08_p53	2.0	14.0	7.0	-0.042	0.036	1000.0	-1000.0	-0.004	-1000.0
Nongenotropic Androgen signaling	2.0	136.0	52.0	-0.206	0.104	1000.0	-1000.0	-0.022	-1000.0
IL6-mediated signaling events	2.0	155.0	75.0	-0.159	0.054	1000.0	-1000.0	-0.042	-1000.0
E-cadherin signaling in keratinocytes	2.0	91.0	43.0	-0.13	0.041	1000.0	-1000.0	-0.021	-1000.0
Aurora B signaling	2.0	154.0	67.0	-0.171	0.059	1000.0	-1000.0	-0.04	-1000.0
Caspase cascade in apoptosis	1.0	113.0	74.0	-0.094	0.05	1000.0	-1000.0	-0.033	-1000.0
Coregulation of Androgen receptor activity	1.0	96.0	76.0	-0.084	0.065	1000.0	-1000.0	-0.016	-1000.0
ErbB4 signaling events	1.0	82.0	69.0	-0.111	0.052	1000.0	-1000.0	-0.035	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	30.0	28.0	-0.044	0.05	1000.0	-1000.0	-0.007	-1000.0
Noncanonical Wnt signaling pathway	1.0	44.0	26.0	-0.038	0.038	1000.0	-1000.0	-0.06	-1000.0
Syndecan-2-mediated signaling events	1.0	97.0	69.0	-0.059	0.05	1000.0	-1000.0	-0.024	-1000.0
Cellular roles of Anthrax toxin	1.0	71.0	39.0	-0.184	0.038	1000.0	-1000.0	-0.016	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	70.0	61.0	-0.17	0.07	1000.0	-1000.0	-0.047	-1000.0
Aurora A signaling	1.0	68.0	60.0	-0.085	0.089	1000.0	-1000.0	-0.014	-1000.0
p75(NTR)-mediated signaling	1.0	157.0	125.0	-0.175	0.069	1000.0	-1000.0	-0.025	-1000.0
IL4-mediated signaling events	1.0	131.0	91.0	-0.524	0.277	1000.0	-1000.0	-0.1	-1000.0
BMP receptor signaling	1.0	118.0	81.0	-0.063	0.079	1000.0	-1000.0	-0.024	-1000.0
EPO signaling pathway	1.0	71.0	55.0	0.0	0.092	1000.0	-1000.0	-0.016	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	138.0	97.0	-0.087	0.061	1000.0	-1000.0	-0.06	-1000.0
PDGFR-alpha signaling pathway	1.0	80.0	44.0	-0.223	0.046	1000.0	-1000.0	-0.027	-1000.0
amb2 Integrin signaling	1.0	122.0	82.0	-0.082	0.063	1000.0	-1000.0	-0.027	-1000.0
Nectin adhesion pathway	1.0	71.0	63.0	-0.131	0.079	1000.0	-1000.0	-0.045	-1000.0
Glucocorticoid receptor regulatory network	1.0	129.0	114.0	-0.278	0.083	1000.0	-1000.0	-0.044	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	45.0	37.0	-0.078	0.065	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by HDAC Class III	1.0	75.0	40.0	-0.143	0.111	1000.0	-1000.0	-0.034	-1000.0
TRAIL signaling pathway	1.0	53.0	48.0	-0.002	0.068	1000.0	-1000.0	-0.023	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	65.0	52.0	-0.255	0.112	1000.0	-1000.0	-0.031	-1000.0
S1P1 pathway	1.0	67.0	36.0	-0.125	0.037	1000.0	-1000.0	-0.031	-1000.0
FAS signaling pathway (CD95)	1.0	56.0	47.0	-0.039	0.052	1000.0	-1000.0	-0.053	-1000.0
Signaling mediated by p38-alpha and p38-beta	1.0	75.0	44.0	-0.059	0.036	1000.0	-1000.0	-0.014	-1000.0
Integrins in angiogenesis	1.0	122.0	84.0	-0.078	0.089	1000.0	-1000.0	-0.026	-1000.0
TCR signaling in naïve CD8+ T cells	1.0	131.0	93.0	-0.139	0.165	1000.0	-1000.0	-0.03	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	45.0	45.0	-0.028	0.068	1000.0	-1000.0	-0.038	-1000.0
Canonical Wnt signaling pathway	1.0	58.0	51.0	-0.17	0.088	1000.0	-1000.0	-0.04	-1000.0
EPHB forward signaling	1.0	121.0	85.0	-0.058	0.079	1000.0	-1000.0	-0.042	-1000.0
Effects of Botulinum toxin	1.0	40.0	26.0	-0.147	0.063	1000.0	-1000.0	-0.002	-1000.0
Glypican 2 network	1.0	6.0	4.0	-0.0	0.018	1000.0	-1000.0	-0.0	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	60.0	31.0	-0.098	0.049	1000.0	-1000.0	-0.043	-1000.0
IL27-mediated signaling events	1.0	57.0	51.0	-0.098	0.061	1000.0	-1000.0	-0.053	-1000.0
Wnt signaling	1.0	12.0	7.0	-0.035	0.036	1000.0	-1000.0	-0.009	-1000.0
LPA receptor mediated events	1.0	107.0	102.0	-0.138	0.058	1000.0	-1000.0	-0.072	-1000.0
Class I PI3K signaling events	1.0	112.0	73.0	-0.066	0.049	1000.0	-1000.0	-0.02	-1000.0
BCR signaling pathway	1.0	185.0	99.0	-0.101	0.052	1000.0	-1000.0	-0.052	-1000.0
EGFR-dependent Endothelin signaling events	1.0	26.0	21.0	-0.025	0.067	1000.0	-1000.0	0.0	-1000.0
Syndecan-4-mediated signaling events	1.0	85.0	67.0	-0.096	0.05	1000.0	-1000.0	-0.035	-1000.0
Angiopoietin receptor Tie2-mediated signaling	1.0	127.0	88.0	-0.146	0.05	1000.0	-1000.0	-0.066	-1000.0
Rapid glucocorticoid signaling	1.0	28.0	20.0	-0.09	0.038	1000.0	-1000.0	-0.0	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	136.0	120.0	-0.148	0.1	1000.0	-1000.0	-0.05	-1000.0
Visual signal transduction: Rods	1.0	93.0	52.0	-0.058	0.048	1000.0	-1000.0	-0.006	-1000.0
Signaling events mediated by PRL	1.0	66.0	34.0	-0.176	0.041	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	134.0	78.0	-0.076	0.05	1000.0	-1000.0	-0.045	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	26.0	17.0	-0.038	0.033	1000.0	-1000.0	-0.023	-1000.0
LPA4-mediated signaling events	0.0	7.0	12.0	-0.049	0.011	1000.0	-1000.0	-0.011	-1000.0
ErbB2/ErbB3 signaling events	0.0	56.0	65.0	-0.061	0.049	1000.0	-1000.0	-0.072	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	6.0	23.0	-0.008	0.064	1000.0	-1000.0	-0.016	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	8.0	34.0	-0.037	0.073	1000.0	-1000.0	-0.028	-1000.0
Canonical NF-kappaB pathway	0.0	17.0	39.0	-0.028	0.101	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by HDAC Class II	0.0	32.0	75.0	-0.05	0.095	1000.0	-1000.0	-0.013	-1000.0
BARD1 signaling events	0.0	54.0	57.0	-0.061	0.077	1000.0	-1000.0	-0.036	-1000.0
Circadian rhythm pathway	0.0	17.0	22.0	-0.072	0.061	1000.0	-1000.0	-0.035	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	38.0	54.0	-0.038	0.067	1000.0	-1000.0	-0.025	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	7.0	17.0	-0.002	0.056	1000.0	-1000.0	-0.019	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	0.013	0.038	1000.0	-1000.0	0.019	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	58.0	85.0	-0.317	0.071	1000.0	-1000.0	-0.058	-1000.0
Signaling events mediated by PTP1B	0.0	63.0	76.0	-0.035	0.057	1000.0	-1000.0	-0.038	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	52.0	65.0	-0.034	0.072	1000.0	-1000.0	-0.039	-1000.0
Arf6 downstream pathway	0.0	11.0	43.0	-0.048	0.072	1000.0	-1000.0	-0.028	-1000.0
Aurora C signaling	0.0	3.0	7.0	-0.0	0.054	1000.0	-1000.0	-0.002	-1000.0
FOXA2 and FOXA3 transcription factor networks	0.0	16.0	46.0	-0.066	0.055	1000.0	-1000.0	-0.056	-1000.0
Glypican 1 network	0.0	39.0	48.0	-0.038	0.068	1000.0	-1000.0	-0.022	-1000.0
Insulin-mediated glucose transport	0.0	13.0	32.0	-0.0	0.051	1000.0	-1000.0	-0.016	-1000.0
mTOR signaling pathway	0.0	26.0	53.0	-0.102	0.052	1000.0	-1000.0	-0.037	-1000.0
IFN-gamma pathway	0.0	42.0	68.0	-0.049	0.054	1000.0	-1000.0	-0.047	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	20.0	68.0	-0.044	0.06	1000.0	-1000.0	-0.031	-1000.0
Ceramide signaling pathway	0.0	70.0	76.0	-0.078	0.067	1000.0	-1000.0	-0.037	-1000.0
Reelin signaling pathway	0.0	27.0	56.0	-0.046	0.095	1000.0	-1000.0	-0.018	-1000.0
S1P5 pathway	0.0	4.0	17.0	-0.005	0.038	1000.0	-1000.0	-0.003	-1000.0
ceramide signaling pathway	0.0	44.0	49.0	-0.028	0.054	1000.0	-1000.0	-0.033	-1000.0
HIF-2-alpha transcription factor network	0.0	29.0	43.0	-0.106	0.095	1000.0	-1000.0	-0.045	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	52.0	83.0	-0.021	0.074	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by HDAC Class I	0.0	34.0	104.0	-0.045	0.072	1000.0	-1000.0	-0.027	-1000.0
FoxO family signaling	0.0	33.0	64.0	-0.125	0.066	1000.0	-1000.0	-0.043	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	11.0	15.0	-0.051	0.036	1000.0	-1000.0	-0.013	-1000.0
Retinoic acid receptors-mediated signaling	0.0	31.0	58.0	-0.057	0.075	1000.0	-1000.0	-0.026	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	26.0	36.0	-0.078	0.074	1000.0	-1000.0	-0.027	-1000.0
Atypical NF-kappaB pathway	0.0	14.0	31.0	-0.008	0.052	1000.0	-1000.0	-0.007	-1000.0
IL2 signaling events mediated by PI3K	0.0	20.0	58.0	-0.013	0.065	1000.0	-1000.0	-0.033	-1000.0
Regulation of p38-alpha and p38-beta	0.0	45.0	54.0	-0.033	0.086	1000.0	-1000.0	-0.02	-1000.0
TCGA08_rtk_signaling	0.0	22.0	26.0	-0.034	0.052	1000.0	-1000.0	-0.004	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.0	0.086	1000.0	-1000.0	-0.022	-1000.0
IL2 signaling events mediated by STAT5	0.0	15.0	22.0	-0.074	0.04	1000.0	-1000.0	-0.027	-1000.0
Arf6 trafficking events	0.0	15.0	71.0	-0.047	0.049	1000.0	-1000.0	-0.025	-1000.0
Regulation of Telomerase	0.0	85.0	102.0	-0.131	0.092	1000.0	-1000.0	-0.049	-1000.0
IGF1 pathway	0.0	19.0	57.0	-0.033	0.09	1000.0	-1000.0	-0.028	-1000.0
Insulin Pathway	0.0	44.0	74.0	-0.039	0.077	1000.0	-1000.0	-0.029	-1000.0
Plasma membrane estrogen receptor signaling	0.0	72.0	86.0	-0.035	0.061	1000.0	-1000.0	-0.043	-1000.0
VEGFR1 specific signals	0.0	11.0	56.0	-0.012	0.079	1000.0	-1000.0	-0.027	-1000.0
S1P3 pathway	0.0	16.0	42.0	-0.04	0.05	1000.0	-1000.0	-0.038	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	17.0	33.0	-0.05	0.087	1000.0	-1000.0	-0.029	-1000.0
PDGFR-beta signaling pathway	0.0	87.0	97.0	-0.064	0.104	1000.0	-1000.0	-0.03	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.035	0.035	1000.0	-1000.0	-0.024	-1000.0
S1P4 pathway	0.0	4.0	25.0	-0.003	0.05	1000.0	-1000.0	-0.014	-1000.0
p38 MAPK signaling pathway	0.0	36.0	44.0	-0.036	0.067	1000.0	-1000.0	-0.02	-1000.0
Arf1 pathway	0.0	3.0	54.0	-0.002	0.047	1000.0	-1000.0	-0.012	-1000.0
Alternative NF-kappaB pathway	0.0	6.0	13.0	0.0	0.058	1000.0	-1000.0	0.0	-1000.0
Regulation of Androgen receptor activity	0.0	50.0	70.0	-0.179	0.063	1000.0	-1000.0	-0.046	-1000.0
Total	139	11027	7203	-13.9516460435	-991.390545843	131000	-131000	-3.87973519612	-131000