rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(3), CDC34(1), CDK2(4), CUL1(6), E2F1(3), FBXW7(4), RB1(13), TFDP1(3)	2895018	37	30	37	3	5	8	9	6	9	0	0.023	0.066	1.00
2	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDK2(4), CDKN1B(3), CUL1(6), E2F1(3), NEDD8(2), RB1(13), SKP2(4), TFDP1(3), UBE2M(1)	2978832	42	33	42	5	5	8	11	7	11	0	0.051	0.11	1.00
3	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(4), IL12A(3), IL2(5)	1033019	14	12	13	1	2	7	2	2	1	0	0.15	0.23	1.00
4	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(4), COQ5(5), COQ6(3), COQ7(1), NDUFA12(2), NDUFA13(4), NDUFB11(1)	1380412	20	14	20	2	5	5	5	1	4	0	0.082	0.32	1.00
5	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(7), SNAP25(4), STX1A(3)	1118665	16	13	16	3	5	3	5	1	2	0	0.20	0.35	1.00
6	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(9), CYP2C9(3)	690893	12	11	12	3	2	3	3	2	2	0	0.54	0.40	1.00
7	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(2), CCNE1(3), CDC34(1), CDK2(4), CUL1(6), E2F1(3), RB1(13), SKP2(4), TFDP1(3)	2974481	39	31	39	6	6	9	9	6	9	0	0.13	0.42	1.00
8	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(5), MTMR2(2), MTMR6(6), NFS1(4), PHPT1(1), TPK1(5)	2218323	25	20	25	3	1	9	6	7	1	1	0.15	0.55	1.00
9	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(6)	566088	6	5	6	0	0	3	2	1	0	0	0.24	0.60	1.00
10	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(2), ALDOB(4), ALDOC(1), TPI1(6)	1340337	13	10	13	0	0	5	4	2	2	0	0.043	0.72	1.00
11	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(3), ALDH1A2(8), BCMO1(4)	1334612	15	13	15	3	2	4	5	1	3	0	0.33	0.76	1.00
12	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(2)	390674	2	2	2	1	0	0	1	1	0	0	0.86	0.76	1.00
13	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	173582	1	1	1	3	0	0	0	0	1	0	1.00	0.77	1.00
14	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(3), MMP2(13), MMP9(10), RECK(7), TIMP1(1), TIMP4(1)	2582662	36	27	36	6	3	6	15	6	6	0	0.11	0.79	1.00
15	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(4), TAT(4)	902718	10	9	10	3	4	3	2	1	0	0	0.52	0.83	1.00
16	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(6), GOT1(2), GOT2(4), TAT(4), TYR(14)	1613763	30	27	30	7	7	10	4	5	4	0	0.30	0.84	1.00
17	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(22), ATR(17), CDC25C(3), CHEK1(6), CHEK2(2)	5229444	50	39	49	5	2	13	17	10	8	0	0.055	0.85	1.00
18	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(1), FOSB(3), GRIA2(15), PPP1R1B(1)	1325681	20	19	20	8	1	6	5	1	7	0	0.78	0.87	1.00
19	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), GSTZ1(1), HGD(4)	772188	6	5	6	1	1	3	0	0	2	0	0.48	0.90	1.00
20	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(2), TGDS(2), UGDH(4), UXS1(4)	1340337	13	12	13	3	1	3	5	1	3	0	0.59	0.90	1.00
21	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), GOT1(2), GOT2(4), GPT2(3), MDH1(2), MDH2(2), ME1(1), ME2(7), ME3(2), PGK1(5), PKLR(11), PKM2(4), RPE(2), RPIA(5), TKT(1), TPI1(6)	6166283	65	42	64	7	10	19	17	10	9	0	0.0021	0.91	1.00
22	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(4), HADH(4), HADHA(3), HADHB(4), HSD17B4(5), MECR(1), PPT1(2), PPT2(7)	2924330	30	23	28	5	4	5	9	3	8	1	0.11	0.92	1.00
23	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(4), IFNG(4), IL10(1), IL12A(3), IL13(1), IL15(2), IL16(9), IL1A(3), IL2(5), IL3(1), IL4(1), LTA(2)	3410955	36	29	35	5	2	15	11	6	2	0	0.067	0.93	1.00
24	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(5), SPCS1(1), SPCS3(1)	1063476	7	7	7	2	0	1	3	2	1	0	0.61	0.94	1.00
25	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(2), TGDS(2), UGDH(4), UGP2(1), UXS1(4)	1699180	14	12	14	3	2	3	5	1	3	0	0.52	0.95	1.00
26	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYB(1), NFYC(2), RB1(13), SP1(1), SP3(4)	2300534	21	19	21	6	1	3	3	4	10	0	0.74	0.95	1.00
27	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(3), CSF1(1), HLA-DRA(3), IFNB1(4), IFNG(4), IL10(1), IL12A(3), IL13(1), IL15(2), IL1A(3), IL2(5), IL3(1), IL4(1), LTA(2), PDGFA(6), TGFB1(2), TGFB2(8), TGFB3(1)	4545421	51	39	50	9	4	17	13	10	7	0	0.099	0.96	1.00
28	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), ACAT2(1), OXCT1(4)	1160343	6	5	6	2	1	1	1	1	1	1	0.78	0.98	1.00
29	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2)	524181	2	1	2	0	1	1	0	0	0	0	0.61	0.99	1.00
30	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), GOT1(2), GOT2(4), GPT2(3), MDH1(2), MDH2(2), ME1(1), ME3(2), PGK1(5), PGK2(14), PKLR(11), PKM2(4), RPE(2), RPIA(5), TKT(1), TKTL1(10), TKTL2(12), TPI1(6)	6892442	94	64	93	15	13	32	21	14	14	0	0.0079	0.99	1.00
31	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(3), CD80(4), HLA-DRA(3), IL10(1), IL2(5), IL4(1)	1359344	18	16	17	5	0	8	4	3	3	0	0.67	0.99	1.00
32	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(3), HLA-DRA(3)	809744	7	7	7	3	0	2	3	1	1	0	0.82	0.99	1.00
33	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(8), HADHA(3), SDS(2)	1650174	13	11	12	4	1	5	3	1	2	1	0.73	0.99	1.00
34	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(3), GLS2(2), GLUD1(3), GLUD2(5)	1555597	13	12	13	4	1	4	6	2	0	0	0.64	0.99	1.00
35	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(4), ACAT1(1), ACAT2(1), EHHADH(8), HADHA(3), HADHB(4), SDS(2)	2851966	23	19	22	5	1	6	8	2	5	1	0.41	0.99	1.00
36	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	SLPI(1)	581889	1	1	1	1	0	0	1	0	0	0	0.96	0.99	1.00
37	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	4	GGT1(1), SHMT1(2), SHMT2(2)	1134008	5	5	5	2	3	0	2	0	0	0	0.57	1.00	1.00
38	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3D(2), IFNG(4), IL2(5), IL2RA(3), IL4(1), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), TGFBR3(13), TOB1(1), TOB2(3)	3648199	48	36	46	10	6	20	8	7	7	0	0.26	1.00	1.00
39	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(3), CD34(4), CD3D(2), CD4(3), CD58(1), CD8A(2), IL3(1)	2134738	16	13	16	4	3	2	6	2	3	0	0.33	1.00	1.00
40	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP3(4), CASP8(4), CFLAR(1), PDE6D(1)	1316521	11	7	11	5	4	0	4	1	2	0	0.79	1.00	1.00
41	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH6(8), ADH7(4), ADHFE1(2)	1931157	42	27	42	11	2	29	3	4	4	0	0.60	1.00	1.00
42	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	ARF3(1), CCND1(2), CDK2(4), CDK4(2), CDKN1A(1), CDKN1B(3), E2F1(3), MDM2(2), NXT1(1), PRB1(3)	2444804	22	15	22	5	7	6	3	2	4	0	0.34	1.00	1.00
43	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(1), CD3D(2), CD4(3)	1101948	7	7	7	6	0	2	2	1	2	0	0.97	1.00	1.00
44	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(3), ACAT1(1), HADHA(3)	1846885	7	7	7	5	0	0	1	2	3	1	0.97	1.00	1.00
45	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), ACAT2(1), ACYP2(1), EHHADH(8), GCDH(3), HADHA(3), SDHB(1), SDS(2)	2671972	20	17	18	5	1	5	9	1	3	1	0.53	1.00	1.00
46	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(2), CRY1(3), CRY2(2), CSNK1E(6), PER1(3)	2947917	18	13	18	3	7	3	6	0	2	0	0.18	1.00	1.00
47	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(6), DCN(1), FMOD(2), KERA(3), LUM(6)	1242783	18	15	18	5	2	5	3	6	2	0	0.59	1.00	1.00
48	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), FDPS(1), IDI1(1), SQLE(1)	1101032	5	5	5	3	0	2	2	0	1	0	0.87	1.00	1.00
49	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(22), CDC25A(4), CDC25B(1), CDC25C(3), CHEK1(6), MYT1(6), WEE1(3)	4733659	45	34	44	8	2	12	11	10	10	0	0.25	1.00	1.00
50	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(4), IFNGR1(3), IFNGR2(3), JAK1(8), JAK2(4), STAT1(4)	2833188	26	23	26	6	4	4	8	5	5	0	0.38	1.00	1.00
51	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	6	EEA1(6), EGF(9), RAB5A(1), TF(4), TFRC(6)	3497975	26	17	26	4	2	9	7	4	4	0	0.29	1.00	1.00
52	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(5), PARK2(7), SNCA(3), SNCAIP(4), UBE2E2(1), UBE2G2(1), UBE2L6(1)	2197713	22	19	22	5	2	11	6	2	1	0	0.43	1.00	1.00
53	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(14), PNPO(1), PSAT1(2)	1669868	17	15	17	7	2	7	2	2	4	0	0.86	1.00	1.00
54	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(2), B3GALT1(2), B3GALT2(2), B3GALT5(1), B3GNT5(1), FUT1(2), FUT3(2), ST3GAL3(1), ST3GAL4(2)	2472284	15	11	15	4	4	4	4	1	2	0	0.47	1.00	1.00
55	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(5), BCKDK(2), CBS(1), CTH(1), MUT(6)	1685440	15	13	15	9	2	5	3	1	4	0	0.96	1.00	1.00
56	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	HPRT1(1), IMPDH1(4), MTHFD2(1), POLB(2), POLD1(2), POLG(11), PRPS2(2), RRM1(5), SRM(2)	4356954	30	21	30	5	11	3	9	4	3	0	0.075	1.00	1.00
57	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(22), CDC25A(4), CDC25B(1), CDC25C(3), CDK2(4), CDK4(2), CHEK1(6), MYT1(6), RB1(13), WEE1(3)	5782250	64	45	63	11	7	15	12	11	19	0	0.15	1.00	1.00
58	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), GAD1(5), HDC(7), TH(2), TPH1(11)	2096495	27	17	27	8	7	6	5	6	3	0	0.58	1.00	1.00
59	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(4), JAK1(8), PTPRU(10), REG1A(9), STAT1(4), STAT2(5), TYK2(2)	4318711	42	33	41	8	4	13	8	10	7	0	0.20	1.00	1.00
60	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PLCG1(5), PRKCA(7), PTK2B(8)	2300534	20	16	20	5	8	6	5	1	0	0	0.37	1.00	1.00
61	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(5), CSAD(3), GAD1(5), GAD2(10), GGT1(1)	1941004	24	20	24	7	5	4	6	6	3	0	0.52	1.00	1.00
62	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	6	EPHX2(1), HSD3B7(2), RDH11(2)	1449570	5	5	5	2	0	3	2	0	0	0	0.80	1.00	1.00
63	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3)	2760595	31	24	31	9	5	10	9	4	3	0	0.45	1.00	1.00
64	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3)	2760595	31	24	31	9	5	10	9	4	3	0	0.45	1.00	1.00
65	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(2), BFAR(1), CAMP(2), CREB5(7), RAF1(3), SNX13(3), SRC(2)	3428130	20	12	20	4	6	6	4	2	2	0	0.31	1.00	1.00
66	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(2), HLA-DRA(3), IL3(1)	1035309	6	6	6	3	0	1	3	2	0	0	0.88	1.00	1.00
67	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(2), IFNB1(4), JAK1(8), STAT1(4), STAT2(5), TYK2(2)	3732929	25	23	25	5	1	4	6	8	6	0	0.42	1.00	1.00
68	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(11), GNA12(1), PRKACB(3), PRKACG(1), PRKAR2A(1)	3484922	17	13	17	3	2	5	6	2	2	0	0.27	1.00	1.00
69	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(6), ANKRD1(6), CYR61(1), DUSP14(1), EIF4E(3), HBEGF(1), IFNG(4), IFRD1(1), IL1A(3), IL1R1(1), MYOG(1), NR4A3(2), WDR1(2)	3770714	32	24	32	7	6	7	13	4	2	0	0.23	1.00	1.00
70	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), HSD3B7(2), PON1(3), PON3(5), RDH11(2)	2890209	20	18	20	5	1	7	7	4	1	0	0.41	1.00	1.00
71	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	5	HDAC1(3), MAX(3), SP1(1), SP3(4)	1867495	11	10	11	5	0	2	3	3	3	0	0.88	1.00	1.00
72	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(2), CCNA2(4), CCND1(2), CCNE1(3), CDK2(4), CDK4(2), CDKN1B(3), E2F1(3), PRB1(3)	2919979	26	19	26	7	6	6	7	3	4	0	0.40	1.00	1.00
73	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), FDPS(1), GGPS1(1), IDI1(1), SQLE(1)	1470867	6	6	6	4	0	3	2	0	1	0	0.92	1.00	1.00
74	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(5), ALPL(2), ALPP(4), ALPPL2(3), FPGS(1), GCH1(4), GGH(4)	2288626	23	18	23	7	2	2	8	6	5	0	0.52	1.00	1.00
75	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(3), CASP8(4), FADD(1), RIPK1(4), TNFRSF1B(1), TRAF2(1)	2916544	15	12	15	3	1	2	7	2	3	0	0.38	1.00	1.00
76	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(2), CREBBP(4), DFFA(3), DFFB(2), GZMA(4), GZMB(3), HMGB2(4), PRF1(5), SET(1)	3651634	29	21	29	6	5	9	7	4	4	0	0.34	1.00	1.00
77	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(1), GLS(3), GLUD1(3), OAT(1)	1919478	11	10	11	4	2	1	6	1	1	0	0.67	1.00	1.00
78	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), CDC42(2), WASF1(8), WASL(5)	2788991	27	22	27	9	1	7	9	3	7	0	0.88	1.00	1.00
79	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(4), CASP7(1), DFFA(3), DFFB(2), GZMB(3), HMGB2(4), TOP2A(6), TOP2B(4)	3305615	27	18	26	6	8	6	4	5	4	0	0.46	1.00	1.00
80	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(4), LPL(5), NR3C1(3), PPARG(3), RXRA(1)	1996193	16	15	16	8	1	6	3	3	3	0	0.94	1.00	1.00
81	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CCNH(1), CDC25A(4), CDC25B(1), CDC25C(3), CDK7(3), MNAT1(2), SHH(4), XPO1(3)	3034937	22	18	22	5	1	7	6	5	3	0	0.48	1.00	1.00
82	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(4), HRAS(1), PTK2B(8), SHC1(2), SOS1(12), SRC(2)	3031273	29	19	29	8	8	8	5	7	1	0	0.44	1.00	1.00
83	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(7), APC(23), AXIN1(3), BTRC(9), CTNNB1(11), DLL1(5), DVL1(1), FZD1(3), GSK3B(2), NOTCH1(8), PSEN1(1), WNT1(3)	7428531	76	52	73	12	10	18	24	10	14	0	0.030	1.00	1.00
84	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(2), B3GNT1(3), FUT1(2), FUT9(7), GCNT2(2), ST8SIA1(2)	2110693	18	18	17	9	3	3	5	4	3	0	0.91	1.00	1.00
85	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), ACAT2(1), BDH2(1), HMGCS1(5), HMGCS2(6), OXCT1(4)	2479383	18	12	18	5	1	6	4	3	2	2	0.64	1.00	1.00
86	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB4A(2), RAB5A(1)	1469493	7	7	7	3	0	2	1	3	1	0	0.89	1.00	1.00
87	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(9), LARS(7), LARS2(2), PDHA1(3), PDHA2(13)	3442557	35	28	35	9	3	11	8	8	5	0	0.57	1.00	1.00
88	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	FOS(1), FXYD2(1), MAFG(1), MAPK14(1), MAPK8(3), NFE2L2(5), PRKCA(7)	2664186	19	16	19	7	5	4	5	1	4	0	0.73	1.00	1.00
89	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(4), PLCD1(2), PRKCA(7), TGM2(3)	1714523	16	14	16	5	4	5	4	2	1	0	0.58	1.00	1.00
90	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(4), CD36(4), FOS(1), FYN(3), MAPK14(1), THBS1(4)	2528847	17	11	16	5	5	4	2	3	3	0	0.58	1.00	1.00
91	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(1), EGR1(2), HRAS(1), KLK2(4), MAP2K1(6), MAP2K2(1), MAPK3(1), NGFR(2), RAF1(3)	2857691	21	18	21	6	3	6	5	5	2	0	0.40	1.00	1.00
92	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(3), ST3GAL2(3), ST3GAL4(2), ST6GALNAC4(1), ST8SIA1(2)	1949706	11	11	11	8	3	0	6	0	2	0	0.93	1.00	1.00
93	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(5), SRP19(1), SRP54(2), SRP68(2), SRP72(2), SRPR(4)	2570754	17	11	16	9	3	5	6	0	3	0	0.97	1.00	1.00
94	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(5), LDLR(4), MBTPS1(6), MBTPS2(2), SCAP(4), SREBF1(2), SREBF2(2)	4127496	25	20	25	6	3	4	11	4	2	1	0.26	1.00	1.00
95	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(2), AASS(7), KARS(4)	1625442	14	10	14	6	3	4	3	3	1	0	0.88	1.00	1.00
96	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(3), CD8A(2), CSF1(1), EPO(3), IL2(5), IL3(1), IL4(1)	2063748	16	14	15	5	0	8	4	2	2	0	0.59	1.00	1.00
97	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CSF1(1), LDLR(4), LPL(5)	1832916	11	11	11	6	1	3	3	3	1	0	0.92	1.00	1.00
98	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(16), HSD17B2(3), HSD17B3(1), HSD17B4(5), HSD17B7(1), HSD3B1(7), HSD3B2(13)	2802273	49	36	48	13	6	17	12	7	6	1	0.46	1.00	1.00
99	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	EIF2B5(3), EIF2S3(2), EIF4E(3), GSK3B(2), IGF1(5), IGF1R(10), INPPL1(8), PDK2(2), PDPK1(1), PIK3CA(11), PIK3R1(3), PPP2CA(1), PTEN(8), RPS6KB1(2)	6777484	61	38	56	11	10	18	18	5	10	0	0.089	1.00	1.00
100	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	9	EPX(7), LPO(4), MPO(4), PRDX1(2), PRDX2(1), PRDX5(1), PRDX6(3), TPO(16), TYR(14)	2999671	52	43	52	14	5	17	13	11	6	0	0.40	1.00	1.00
101	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), MST1(5), MST1R(4)	2269848	10	10	8	8	1	2	5	0	2	0	0.99	1.00	1.00
102	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(6), EIF2AK4(6), EIF2B5(3), EIF2S3(2), EIF5(2), GSK3B(2), PPP1CA(2)	3996966	23	16	23	5	4	10	5	1	3	0	0.53	1.00	1.00
103	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(2), FUT1(2), FUT3(2), ST3GAL3(1)	1754827	7	7	7	4	3	0	2	1	1	0	0.87	1.00	1.00
104	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS1(3), CPOX(4), FECH(2), HMBS(3), PPOX(3)	2627546	17	12	17	5	4	4	4	3	2	0	0.55	1.00	1.00
105	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(2), CD4(3), HLA-DRA(3), IL4(1), IL5RA(5)	1824443	14	14	14	5	0	4	6	3	1	0	0.75	1.00	1.00
106	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(7), DLL1(5), FURIN(7), NOTCH1(8), PSEN1(1)	3239434	28	22	28	8	7	6	5	3	7	0	0.52	1.00	1.00
107	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(18), RANGAP1(3)	2892499	21	15	21	8	5	7	4	2	2	1	0.84	1.00	1.00
108	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(4), CDC25B(1), CDK7(3), CDKN1A(1), CHEK1(6), NEK1(6), WEE1(3)	2473429	24	19	24	8	1	9	6	6	2	0	0.83	1.00	1.00
109	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(8), AASDHPPT(2), AASS(7), KARS(4)	2393279	22	17	22	8	5	7	4	4	2	0	0.83	1.00	1.00
110	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(3), DNAJC3(3), MAP3K14(1), NFKB1(3), NFKBIA(1)	3084859	11	10	11	7	1	1	5	0	4	0	0.97	1.00	1.00
111	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNG(4), IFNGR1(3), JAK1(8), JAK2(4), PLA2G2A(3), PTPRU(10), REG1A(9), STAT1(4)	3982997	45	35	44	10	5	14	9	9	8	0	0.31	1.00	1.00
112	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), ACO2(1), FH(7), IDH1(2), IDH2(2), MDH1(2), MDH2(2), SDHB(1)	3049364	21	18	21	6	2	6	5	4	4	0	0.59	1.00	1.00
113	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(2), ACP2(1), ACP5(3), ACPP(7), ENPP1(6), ENPP3(12), FLAD1(3), TYR(14)	3340652	48	44	48	12	5	14	16	7	6	0	0.37	1.00	1.00
114	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(3), PAPSS1(3), PAPSS2(4), SULT1A2(1), SULT1E1(1), SULT2A1(3), SUOX(5)	2092144	20	18	20	7	2	6	7	4	1	0	0.74	1.00	1.00
115	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	CDK5(1), CSNK1D(2), DRD1(3), DRD2(9), GRM1(26), PLCB1(18), PPP1CA(2), PPP1R1B(1), PPP2CA(1), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1)	5177690	75	59	75	18	10	26	27	2	10	0	0.16	1.00	1.00
116	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(2), PSMA4(1), PSMA6(3), PSMA7(1), PSMB4(4), PSMB5(1), PSMB6(1), PSMD14(2), RPN2(4), UBE2A(4), UBE3A(8)	4451531	31	22	31	7	6	8	8	6	3	0	0.26	1.00	1.00
117	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(4), NR0B2(1), NR1H3(4), NR1H4(5), RXRA(1)	1876884	16	14	16	6	1	3	7	4	1	0	0.74	1.00	1.00
118	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(2), CCNB1(1), CCND1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(1), CDC25A(4), CDK2(4), CDK4(2), CDK6(3), CDK7(3), CDKN1A(1), CDKN1B(3), CDKN2D(1), E2F1(3), RB1(13), RBL1(7), TFDP1(3)	5382416	58	42	58	13	8	17	12	8	13	0	0.30	1.00	1.00
119	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA2(3), IL4R(5), JAK1(8), JAK2(4), TYK2(2)	3607666	23	22	23	7	1	5	6	7	4	0	0.68	1.00	1.00
120	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA2(3), IL4R(5), JAK1(8), JAK2(4), TYK2(2)	3607666	23	22	23	7	1	5	6	7	4	0	0.68	1.00	1.00
121	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), KHK(2), LCT(30), PGM1(2), PYGL(3), PYGM(6), TPI1(6), TREH(1)	4612976	53	40	53	12	8	20	19	3	3	0	0.14	1.00	1.00
122	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), ACO2(1), CS(1), GRHPR(1), HAO1(4), HAO2(8), MDH1(2), MDH2(2), MTHFD1(1), MTHFD1L(5), MTHFD2(1)	4388785	30	24	30	9	6	10	5	3	6	0	0.57	1.00	1.00
123	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS1(3), CPO(3), FECH(2), GATA1(2), HBB(4), HMBS(3)	2723039	19	14	19	7	3	10	2	2	2	0	0.76	1.00	1.00
124	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(3), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT5(3), FUT8(4), ST3GAL1(3), ST3GAL2(3), ST3GAL3(1), ST3GAL4(2)	2714337	23	17	22	8	8	1	9	2	3	0	0.49	1.00	1.00
125	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(5), BMPR1A(1), BMPR1B(5), BMPR2(2)	2163363	13	10	13	6	3	2	4	3	1	0	0.88	1.00	1.00
126	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(2), CAMP(2), DAG1(2), GNAQ(2), ITPKA(1), ITPKB(5)	2119166	14	11	14	6	1	5	4	3	1	0	0.80	1.00	1.00
127	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(9), MAP2K1(6), MAP3K1(4), MAPK14(1), NCOR2(13), RARA(3), RXRA(1), THRA(1), THRB(5)	5004337	43	29	43	10	6	8	11	9	9	0	0.27	1.00	1.00
128	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLD1(2), POLD2(2), POLE(19), POLG(11), POLL(2), POLQ(17)	5740343	55	38	54	12	16	5	20	7	7	0	0.11	1.00	1.00
129	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(4), G6PD(2), GCLC(8), GCLM(1), GGT1(1), GPX1(1), GPX3(1), GPX5(4), GPX6(3), GPX7(3), GSR(1), GSS(3), GSTA1(1), GSTA2(3), GSTA3(2), GSTA4(1), GSTA5(3), GSTK1(4), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(1), IDH1(2), IDH2(2), MGST1(1), MGST3(3), OPLAH(5), TXNDC12(1)	7431279	71	43	71	14	9	21	26	7	7	1	0.042	1.00	1.00
130	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(2), ACP2(1), ACP5(3), ACP6(3), ACPP(7), ENPP1(6), ENPP3(12), FLAD1(3), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(6), PHPT1(1), TYR(14)	5193262	67	54	67	16	6	19	22	13	7	0	0.30	1.00	1.00
131	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(1), B3GAT2(3), B3GAT3(1), CHPF(3), CHST11(1), CHST12(5), CHST13(3), CHST3(2), CHSY1(2), DSE(10), UST(1), XYLT1(19)	4717629	51	44	50	12	4	12	20	10	5	0	0.17	1.00	1.00
132	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), EHHADH(8), HADHA(3), SDS(2)	4179479	44	33	43	12	6	15	12	5	5	1	0.40	1.00	1.00
133	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(2), PSMA4(1), PSMA6(3), PSMA7(1), PSMB4(4), PSMB5(1), PSMB6(1), PSMC2(2), PSMD1(4), PSMD11(5), PSMD12(4), PSMD13(2), PSMD2(3), PSMD6(1)	5480886	34	24	34	8	8	10	9	4	3	0	0.23	1.00	1.00
134	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT2(2), AKT3(5), CDKN1A(1), ELK1(2), GRB2(4), HRAS(1), MAP2K1(6), MAP2K2(1), NGFR(2), PIK3CA(11), PIK3CD(1), SHC1(2), SOS1(12)	5133493	50	38	47	12	2	15	16	13	4	0	0.32	1.00	1.00
135	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(8), ATM(22), BAX(1), BCL2(1), CCND1(2), CCNE1(3), CDK2(4), CDK4(2), CDKN1A(1), E2F1(3), GADD45A(1), MDM2(2), PCNA(1), RB1(13)	5978503	64	49	63	14	8	15	11	11	19	0	0.34	1.00	1.00
136	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(5), DPYD(12), DPYS(10), ENPP1(6), ENPP3(12), PANK1(2), PANK2(4), PANK3(2), PANK4(1), PPCS(1)	4794573	56	43	56	14	7	17	16	7	8	1	0.33	1.00	1.00
137	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(23), AXIN1(3), CCND1(2), CD14(1), CTNNB1(11), DVL1(1), FZD1(3), GJA1(6), GNAI1(3), GSK3B(2), IRAK1(3), LBP(5), LEF1(8), LY96(1), MYD88(3), NFKB1(3), PDPK1(1), PIK3CA(11), PIK3R1(3), PPP2CA(1), TLR4(31), TOLLIP(1), WNT1(3)	10579800	129	81	124	24	13	32	42	18	24	0	0.034	1.00	1.00
138	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	14	ABL1(2), E2F1(3), MDM2(2), PIK3CA(11), PIK3R1(3), POLR1A(8), POLR1B(10), POLR1D(2), RB1(13), TBX2(1), TWIST1(1)	6524668	56	39	52	12	8	10	18	7	13	0	0.18	1.00	1.00
139	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(4), ACO2(1), ACSS1(4), ACSS2(4), FH(7), IDH1(2), IDH2(2), MDH1(2), MDH2(2)	4555955	30	23	30	9	5	7	7	6	5	0	0.51	1.00	1.00
140	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GUSB(4), HEXA(1), IDS(3), IDUA(2), LCT(30), NAGLU(1)	4924874	42	37	42	11	5	14	13	4	6	0	0.37	1.00	1.00
141	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(23), AXIN1(3), BTRC(9), CCND1(2), CREBBP(4), CSNK1A1(1), CSNK1D(2), CTNNB1(11), DVL1(1), FZD1(3), GSK3B(2), HDAC1(3), MAP3K7(5), PPARD(2), PPP2CA(1), TLE1(3), WNT1(3)	10187065	78	54	75	14	11	19	25	10	13	0	0.058	1.00	1.00
142	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(11), PIK3R1(3), PLCB1(18), PLCG1(5), PRKCA(7), VAV1(1)	4363824	45	38	42	11	7	12	17	2	7	0	0.37	1.00	1.00
143	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(2), PSMA4(1), PSMA6(3), PSMA7(1), PSMB4(4), PSMB5(1), PSMB6(1), PSMB9(1)	3000587	14	9	14	7	4	4	4	1	1	0	0.81	1.00	1.00
144	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), CS(1), MDH1(2), ME1(1), PC(1), PDHA1(3), SLC25A11(2)	3167986	12	11	12	6	3	2	3	3	1	0	0.82	1.00	1.00
145	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), BCAT2(1), IARS(9), IARS2(7), ILVBL(1), LARS(7), LARS2(2), PDHA1(3), PDHA2(13), VARS(6), VARS2(8)	6351773	58	43	58	14	8	16	14	11	9	0	0.31	1.00	1.00
146	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	CCND1(2), CCNE1(3), CDK2(4), CDK4(2), CDK6(3), CDKN1A(1), CDKN1B(3), E2F1(3), HRAS(1), MAPK3(1), NFKB1(3), NFKBIA(1), PAK1(5), PIK3CA(11), PIK3R1(3), RAF1(3), RB1(13), TFDP1(3)	6952211	65	46	62	16	15	14	15	7	14	0	0.25	1.00	1.00
147	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3)	4584351	67	40	67	20	5	37	9	8	8	0	0.65	1.00	1.00
148	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(23), AXIN1(3), CREBBP(4), CTNNB1(11), DVL1(1), EP300(2), FZD1(3), GSK3B(2), HDAC1(3), LDB1(1), LEF1(8), PITX2(4), TRRAP(24), WNT1(3)	11428703	92	56	90	16	17	19	27	13	16	0	0.020	1.00	1.00
149	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(4), CD2(3), CD33(10), CD5(4), IFNB1(4), IFNG(4), IL10(1), IL12A(3), IL13(1), IL3(1), IL4(1), ITGAX(20), TLR2(2), TLR4(31), TLR7(8), TLR9(6)	6388184	103	69	103	28	9	35	24	19	15	1	0.33	1.00	1.00
150	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(4), CHIT1(4), CMAS(3), CYB5R1(1), GFPT1(4), GFPT2(6), GNE(1), GNPDA1(1), GNPDA2(2), HEXA(1), HK1(3), HK2(9), HK3(12), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(6), NAGK(1), NANS(2), NPL(3), PGM3(4), PHPT1(1), RENBP(3), UAP1(6)	9867381	87	58	87	19	15	23	17	22	10	0	0.13	1.00	1.00
151	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(2), CBS(1), CTH(1), GGT1(1), MARS(2), MARS2(8), MAT1A(4), MAT2B(3), PAPSS1(3), PAPSS2(4), SCLY(2), SEPHS1(4)	4248179	35	25	35	10	9	10	10	2	4	0	0.36	1.00	1.00
152	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(23), MAP2(17), PPP1CA(2), PPP2CA(1), PRKACB(3), PRKACG(1), PRKAR2A(1), PRKCE(3)	6259028	51	40	51	11	2	22	13	9	5	0	0.61	1.00	1.00
153	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), ESR2(3), ITPKA(1), PDE1A(8), PDE1B(6), PLCB1(18), PLCB2(6), PRL(1), TRH(1), VIP(1)	3826590	46	37	46	13	7	14	13	3	9	0	0.50	1.00	1.00
154	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(20), ABCB11(15), ABCB4(17), ABCC1(6), ABCC3(7), GSTP1(2)	4930599	67	51	66	20	6	18	22	10	11	0	0.48	1.00	1.00
155	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(23), ASAH1(2), CAMP(2), CASP3(4), CERK(3), CREB5(7), DAG1(2), EPHB2(7), FOS(1), GNAQ(2), ITPKA(1), ITPKB(5), MAP2K4(3), MAP2K7(2), MAPK10(5), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6)	9859137	86	59	86	19	12	19	25	12	18	0	0.15	1.00	1.00
156	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(4), DAXX(6), HRAS(1), PAX3(6), PML(7), RARA(3), RB1(13), SIRT1(1), SP100(9), TNFRSF1B(1)	6334140	51	44	51	13	6	8	16	7	14	0	0.41	1.00	1.00
157	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(2), ATM(22), BRCA1(9), CDKN1A(1), CHEK1(6), CHEK2(2), GADD45A(1), MAPK8(3), MDM2(2), MRE11A(6), NFKB1(3), NFKBIA(1), RAD50(3), RAD51(1), RBBP8(3), TP73(4)	9990125	69	51	68	14	7	19	22	10	11	0	0.26	1.00	1.00
158	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA1(1), FUCA2(1), HEXA(1), LCT(30), MAN2C1(4), MANBA(4), NEU1(1), NEU3(3), NEU4(6)	5739656	52	45	52	14	6	19	20	4	3	0	0.40	1.00	1.00
159	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	IFNG(4), IFNGR1(3), IFNGR2(3), IKBKB(3), JAK2(4), LIN7A(2), NFKB1(3), NFKBIA(1), RB1(13), TNFRSF1B(1), USH1C(4)	5771945	41	36	41	11	6	8	9	3	15	0	0.50	1.00	1.00
160	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), BCAT2(1), COASY(5), DPYD(12), DPYS(10), ENPP1(6), ENPP3(12), ILVBL(1), PANK1(2), PANK2(4), PANK3(2), PANK4(1), PPCDC(1), PPCS(1), VNN1(4)	5940718	63	47	63	17	7	18	20	9	8	1	0.39	1.00	1.00
161	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	GRB2(4), HRAS(1), KLK2(4), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), SHC1(2), SOS1(12)	4846327	49	39	46	13	7	15	16	8	3	0	0.45	1.00	1.00
162	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(8), BIRC2(2), BIRC3(3), CASP10(6), CASP3(4), CASP7(1), CASP8(4), CASP9(3), DFFA(3), DFFB(2), GZMB(3), PRF1(5), SCAP(4), SREBF1(2), SREBF2(2)	6305515	52	37	52	13	7	11	13	10	11	0	0.32	1.00	1.00
163	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(3), ALOX15(4), ALOX15B(2), ALOX5(6), DPEP1(4), GGT1(1), LTA4H(1), PLA2G2A(3), PLA2G6(1), PTGDS(2), PTGIS(5), PTGS1(5), PTGS2(4), TBXAS1(6)	5174942	47	40	47	13	6	6	17	11	7	0	0.36	1.00	1.00
164	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	189	ACTG1(2), ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), AKT2(2), AKT3(5), ARHGAP5(7), BCAR1(2), BCL2(1), BIRC2(2), BIRC3(3), CAPN2(3), CAV3(2), CCND1(2), CCND2(1), CCND3(1), CDC42(2), CHAD(1), COL11A1(66), COL11A2(7), COL1A1(4), COL1A2(19), COL2A1(7), COL3A1(33), COL4A1(16), COL4A2(16), COL4A4(13), COL4A6(17), COL5A1(17), COL5A2(30), COL5A3(12), COL6A1(4), COL6A2(3), COL6A3(35), COL6A6(24), COMP(2), CRKL(2), CTNNB1(11), DIAPH1(4), DOCK1(7), EGF(9), ELK1(2), ERBB2(10), FARP2(3), FIGF(1), FLNA(11), FLNB(12), FLNC(18), FLT1(21), FN1(13), FYN(3), GRB2(4), GRLF1(9), GSK3B(2), HRAS(1), IBSP(2), IGF1(5), IGF1R(10), ILK(1), ITGA1(9), ITGA10(7), ITGA11(10), ITGA2(11), ITGA2B(4), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), ITGAV(9), ITGB1(3), ITGB3(4), ITGB4(4), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(5), KDR(30), LAMA1(36), LAMA2(33), LAMA3(25), LAMA4(15), LAMA5(15), LAMB1(21), LAMB2(13), LAMB3(8), LAMB4(23), LAMC1(14), LAMC2(9), LAMC3(13), MAP2K1(6), MAPK10(5), MAPK3(1), MAPK8(3), MAPK9(6), MET(12), MYL2(2), MYL5(1), MYL7(3), MYLK(16), MYLK2(3), MYLPF(1), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PARVA(2), PARVB(1), PARVG(2), PDGFA(6), PDGFB(1), PDGFD(4), PDGFRA(17), PDGFRB(8), PDPK1(1), PGF(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PIP5K1C(3), PPP1CA(2), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PRKCA(7), PRKCG(10), PTEN(8), PTK2(11), PXN(1), RAC2(1), RAF1(3), RAP1A(2), RAP1B(1), RAPGEF1(1), RELN(49), RHOA(1), ROCK1(10), ROCK2(4), SHC1(2), SHC2(1), SHC3(4), SHC4(4), SOS1(12), SOS2(6), SRC(2), THBS1(4), THBS2(16), THBS3(6), THBS4(5), TLN1(13), TLN2(15), TNC(21), TNN(34), TNR(40), TNXB(15), VASP(3), VAV1(1), VAV2(3), VAV3(14), VCL(2), VEGFA(1), VEGFC(11), VTN(2), VWF(13), ZYX(2)	126378230	1494	201	1474	490	199	494	372	208	218	3	0.99	1.00	1.00
165	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	198	ABI2(3), ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), APC(23), APC2(2), ARAF(3), ARHGEF1(2), ARHGEF12(11), ARHGEF4(4), ARHGEF6(9), ARHGEF7(6), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), ARPC5(1), BAIAP2(2), BCAR1(2), BDKRB1(1), BDKRB2(1), CD14(1), CDC42(2), CFL2(2), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), CRKL(2), CYFIP1(7), CYFIP2(8), DIAPH1(4), DIAPH2(6), DIAPH3(6), DOCK1(7), EGF(9), EZR(1), F2(5), F2R(4), FGD1(2), FGD3(6), FGF1(1), FGF10(2), FGF12(4), FGF13(6), FGF18(1), FGF19(2), FGF20(1), FGF21(2), FGF23(4), FGF3(1), FGF4(2), FGF5(2), FGF9(1), FGFR1(5), FGFR2(8), FGFR3(2), FGFR4(3), FN1(13), GNA12(1), GNA13(5), GNG12(2), GRLF1(9), GSN(3), HRAS(1), IQGAP1(5), IQGAP2(13), IQGAP3(6), ITGA1(9), ITGA10(7), ITGA11(10), ITGA2(11), ITGA2B(4), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), ITGAD(17), ITGAE(9), ITGAL(20), ITGAM(14), ITGAV(9), ITGAX(20), ITGB1(3), ITGB2(2), ITGB3(4), ITGB4(4), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(5), LIMK2(1), MAP2K1(6), MAP2K2(1), MAPK3(1), MOS(2), MRAS(1), MSN(1), MYH10(6), MYH14(2), MYH9(8), MYL2(2), MYL5(1), MYL7(3), MYLK(16), MYLK2(3), MYLPF(1), NCKAP1(4), NCKAP1L(12), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PDGFA(6), PDGFB(1), PDGFRA(17), PDGFRB(8), PFN1(1), PFN2(3), PFN4(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PIP4K2A(5), PIP4K2B(2), PIP4K2C(3), PIP5K1A(5), PIP5K1B(7), PIP5K1C(3), PPP1CA(2), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R12B(5), PTK2(11), PXN(1), RAC2(1), RAF1(3), RDX(2), RHOA(1), ROCK1(10), ROCK2(4), RRAS(1), RRAS2(1), SCIN(4), SLC9A1(3), SOS1(12), SOS2(6), SSH1(4), SSH2(4), SSH3(2), TIAM1(19), TIAM2(11), TMSL3(1), VAV1(1), VAV2(3), VAV3(14), VCL(2), WAS(3), WASF1(8), WASF2(1), WASL(5)	93840994	898	199	893	296	128	259	239	147	123	2	0.91	1.00	1.00
166	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	233	ADCYAP1R1(6), ADORA1(1), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA1B(4), ADRA2A(1), ADRA2B(1), ADRA2C(3), ADRB2(2), ADRB3(3), AGTR1(5), AGTR2(2), AVPR1A(6), AVPR1B(3), AVPR2(4), BDKRB1(1), BDKRB2(1), BRS3(8), C3AR1(5), C5AR1(4), CALCR(8), CALCRL(10), CCKAR(7), CCKBR(11), CGA(1), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), CNR1(4), CNR2(1), CRHR1(1), CRHR2(2), CTSG(2), CYSLTR1(1), CYSLTR2(4), DRD1(3), DRD2(9), DRD3(9), DRD5(9), EDNRB(6), F2(5), F2R(4), F2RL1(1), F2RL2(5), F2RL3(2), FPR1(4), FSHB(1), FSHR(20), GABBR1(3), GABBR2(6), GABRA1(8), GABRA2(14), GABRA3(8), GABRA4(10), GABRA6(12), GABRB1(11), GABRB2(3), GABRD(1), GABRE(5), GABRG1(14), GABRG2(10), GABRG3(10), GABRP(5), GABRQ(11), GABRR1(6), GABRR2(5), GALR1(3), GALR2(1), GH1(2), GH2(5), GHR(5), GHRHR(5), GHSR(4), GIPR(2), GLP1R(1), GLP2R(9), GLRA1(5), GLRA2(10), GLRA3(2), GLRB(4), GNRHR(2), GPR156(6), GPR50(7), GPR63(4), GPR83(4), GRIA1(12), GRIA2(15), GRIA3(11), GRIA4(9), GRID1(14), GRID2(22), GRIK1(11), GRIK2(19), GRIK3(10), GRIK4(8), GRIK5(6), GRIN1(2), GRIN2A(26), GRIN2B(22), GRIN2C(3), GRIN2D(6), GRIN3A(19), GRM1(26), GRM2(5), GRM3(9), GRM4(9), GRM5(13), GRM6(7), GRM7(15), GRM8(19), GRPR(5), GZMA(4), HCRTR1(1), HCRTR2(13), HRH1(6), HRH2(6), HRH3(1), HRH4(4), HTR1A(13), HTR1B(5), HTR1D(1), HTR1E(9), HTR1F(4), HTR2A(3), HTR2B(2), HTR2C(6), HTR5A(11), HTR6(5), HTR7(3), LEP(4), LEPR(13), LHB(1), LHCGR(6), LTB4R(2), MAS1(3), MC2R(2), MC3R(9), MC4R(1), MC5R(10), MCHR2(7), MLNR(1), MTNR1A(5), MTNR1B(6), NMBR(6), NMUR1(4), NMUR2(11), NPBWR1(4), NPBWR2(2), NPY1R(9), NPY2R(6), NPY5R(9), NR3C1(3), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(5), OPRL1(5), OPRM1(4), OXTR(2), P2RX1(1), P2RX2(4), P2RX3(3), P2RX4(1), P2RX5(4), P2RX7(5), P2RY1(5), P2RY10(10), P2RY14(2), P2RY4(1), P2RY6(1), P2RY8(3), PARD3(6), PPYR1(2), PRL(1), PRLHR(5), PRLR(9), PRSS1(12), PRSS3(1), PTAFR(2), PTGDR(3), PTGER2(2), PTGER3(4), PTGER4(7), PTGFR(6), PTGIR(2), PTH2R(8), RXFP1(11), RXFP2(4), SCTR(1), SSTR1(3), SSTR3(2), SSTR4(5), SSTR5(2), TAAR1(4), TAAR2(6), TAAR5(8), TAAR6(8), TAAR8(5), TAAR9(4), TACR1(3), TACR3(8), THRA(1), THRB(5), TRHR(4), TRPV1(4), TSHB(1), TSHR(10), UTS2R(1), VIPR2(4)	75260850	1238	198	1232	492	132	445	312	217	130	2	1.00	1.00	1.00
167	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	166	ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY7(7), ADCY8(22), ADCY9(3), ADORA2B(1), ADRA1A(4), ADRA1B(4), ADRA1D(2), ADRB2(2), ADRB3(3), AGTR1(5), ATP2A1(3), ATP2A2(6), ATP2A3(4), ATP2B1(9), ATP2B2(11), ATP2B3(11), ATP2B4(9), AVPR1A(6), AVPR1B(3), BDKRB1(1), BDKRB2(1), CACNA1A(10), CACNA1B(15), CACNA1C(26), CACNA1D(17), CACNA1E(50), CACNA1F(10), CACNA1G(10), CACNA1H(9), CACNA1I(7), CACNA1S(11), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), CCKAR(7), CCKBR(11), CD38(3), CHRM1(2), CHRM2(17), CHRM3(13), CHRM5(3), CHRNA7(3), CYSLTR1(1), CYSLTR2(4), DRD1(3), EDNRB(6), ERBB2(10), ERBB3(3), ERBB4(21), F2R(4), GNA11(1), GNAQ(2), GNAS(7), GRIN1(2), GRIN2A(26), GRIN2C(3), GRIN2D(6), GRM1(26), GRM5(13), GRPR(5), HRH1(6), HRH2(6), HTR2A(3), HTR2B(2), HTR2C(6), HTR5A(11), HTR6(5), HTR7(3), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), LHCGR(6), MYLK(16), MYLK2(3), NOS1(9), NOS3(2), NTSR1(5), OXTR(2), P2RX1(1), P2RX2(4), P2RX3(3), P2RX4(1), P2RX5(4), P2RX7(5), PDE1A(8), PDE1B(6), PDE1C(17), PDGFRA(17), PDGFRB(8), PHKA1(4), PHKA2(10), PHKB(7), PHKG1(1), PHKG2(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCD3(2), PLCD4(3), PLCE1(14), PLCG1(5), PLCG2(9), PLCZ1(3), PLN(1), PPID(1), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), PTAFR(2), PTGER3(4), PTGFR(6), PTK2B(8), RYR1(52), RYR2(166), RYR3(53), SLC25A5(2), SLC25A6(5), SLC8A1(26), SLC8A2(3), SLC8A3(7), SPHK2(2), TACR1(3), TACR3(8), TNNC2(2), TRHR(4), TRPC1(9), VDAC3(1)	92099449	1255	194	1242	456	150	415	353	196	136	5	0.99	1.00	1.00
168	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTG1(2), CHAD(1), COL11A1(66), COL11A2(7), COL17A1(9), COL1A1(4), COL1A2(19), COL2A1(7), COL3A1(33), COL4A1(16), COL4A2(16), COL4A4(13), COL4A6(17), COL5A1(17), COL5A2(30), COL5A3(12), COL6A1(4), COL6A2(3), COL6A3(35), COL6A6(24), COMP(2), DSC1(10), DSC2(7), DSC3(13), DSG1(16), DSG2(8), DSG3(16), DSG4(16), FN1(13), GJA1(6), GJA10(4), GJA4(1), GJA5(3), GJA8(7), GJA9(4), GJB1(3), GJB3(1), GJB4(4), GJB5(3), GJB6(1), GJC1(4), GJC2(1), GJD2(2), GJD4(3), IBSP(2), INA(1), ITGA6(5), ITGB4(4), KRT1(4), KRT10(2), KRT12(2), KRT13(5), KRT14(3), KRT15(4), KRT16(3), KRT17(2), KRT18(1), KRT19(1), KRT2(7), KRT20(2), KRT23(2), KRT24(7), KRT25(5), KRT28(8), KRT3(2), KRT31(4), KRT32(4), KRT33A(3), KRT33B(3), KRT34(4), KRT35(4), KRT36(4), KRT37(1), KRT38(8), KRT39(4), KRT4(2), KRT40(3), KRT5(7), KRT6A(7), KRT6B(12), KRT6C(2), KRT7(5), KRT71(8), KRT72(5), KRT73(9), KRT74(5), KRT75(7), KRT76(3), KRT78(1), KRT79(3), KRT8(4), KRT81(2), KRT82(6), KRT83(2), KRT84(3), KRT85(5), KRT86(4), KRT9(2), LAMA1(36), LAMA2(33), LAMA3(25), LAMA4(15), LAMA5(15), LAMB1(21), LAMB2(13), LAMB3(8), LAMB4(23), LAMC1(14), LAMC2(9), LAMC3(13), LMNB1(2), LMNB2(2), NES(10), RELN(49), THBS1(4), THBS2(16), THBS3(6), THBS4(5), TNC(21), TNN(34), TNR(40), TNXB(15), VIM(2), VTN(2), VWF(13)	85825536	1147	192	1139	390	139	400	289	145	171	3	1.00	1.00	1.00
169	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	239	ACVR1B(5), ACVR1C(3), AKT2(2), AKT3(5), ARRB1(2), ARRB2(2), ATF2(5), ATF4(1), BDNF(1), CACNA1A(10), CACNA1B(15), CACNA1C(26), CACNA1D(17), CACNA1E(50), CACNA1F(10), CACNA1G(10), CACNA1H(9), CACNA1I(7), CACNA1S(11), CACNA2D1(19), CACNA2D2(1), CACNA2D3(14), CACNA2D4(6), CACNB1(1), CACNB2(7), CACNB4(1), CACNG1(1), CACNG2(1), CACNG3(7), CACNG4(2), CACNG5(6), CACNG6(3), CACNG7(1), CACNG8(2), CASP3(4), CD14(1), CDC25B(1), CDC42(2), CHUK(3), CRKL(2), DAXX(6), DDIT3(4), DUSP10(6), DUSP14(1), DUSP16(2), DUSP2(1), DUSP6(3), DUSP7(2), DUSP8(1), DUSP9(2), EGF(9), ELK1(2), ELK4(4), FAS(3), FASLG(4), FGF1(1), FGF10(2), FGF12(4), FGF13(6), FGF18(1), FGF19(2), FGF20(1), FGF21(2), FGF23(4), FGF3(1), FGF4(2), FGF5(2), FGF9(1), FGFR1(5), FGFR2(8), FGFR3(2), FGFR4(3), FLNA(11), FLNB(12), FLNC(18), FOS(1), GADD45A(1), GNA12(1), GNG12(2), GRB2(4), HRAS(1), IKBKB(3), IL1A(3), IL1R1(1), IL1R2(4), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K1(4), MAP3K10(1), MAP3K12(5), MAP3K13(7), MAP3K14(1), MAP3K2(5), MAP3K3(4), MAP3K4(14), MAP3K5(12), MAP3K6(1), MAP3K7(5), MAP3K8(2), MAP4K1(5), MAP4K3(5), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK7(5), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(3), MAPT(8), MAX(3), MEF2C(2), MKNK1(2), MKNK2(1), MOS(2), MRAS(1), NF1(29), NFATC2(8), NFATC4(8), NFKB1(3), NFKB2(6), NR4A1(2), NTF3(7), NTRK2(9), PAK1(5), PAK2(3), PDGFA(6), PDGFB(1), PDGFRA(17), PDGFRB(8), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PPM1B(4), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PPP5C(1), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), PTPN5(4), PTPRR(8), RAC2(1), RAF1(3), RAP1A(2), RAP1B(1), RAPGEF2(10), RASA1(3), RASA2(3), RASGRF1(1), RASGRF2(14), RASGRP1(2), RASGRP2(1), RASGRP3(8), RASGRP4(2), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA4(1), RPS6KA5(4), RPS6KA6(5), RRAS(1), RRAS2(1), SOS1(12), SOS2(6), STK4(4), STMN1(1), TAOK1(1), TAOK2(6), TAOK3(7), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), TRAF2(1), TRAF6(4), ZAK(3)	96095270	902	189	898	296	143	222	255	149	128	5	0.77	1.00	1.00
170	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(5), CD36(4), CD44(2), CD47(1), CHAD(1), COL11A1(66), COL11A2(7), COL1A1(4), COL1A2(19), COL2A1(7), COL3A1(33), COL4A1(16), COL4A2(16), COL4A4(13), COL4A6(17), COL5A1(17), COL5A2(30), COL5A3(12), COL6A1(4), COL6A2(3), COL6A3(35), COL6A6(24), DAG1(2), FN1(13), FNDC1(14), FNDC3A(7), FNDC4(1), FNDC5(1), GP5(3), GP6(3), HMMR(4), HSPG2(17), IBSP(2), ITGA1(9), ITGA10(7), ITGA11(10), ITGA2(11), ITGA2B(4), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), ITGAV(9), ITGB1(3), ITGB3(4), ITGB4(4), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(5), LAMA1(36), LAMA2(33), LAMA3(25), LAMA4(15), LAMA5(15), LAMB1(21), LAMB2(13), LAMB3(8), LAMB4(23), LAMC1(14), LAMC2(9), LAMC3(13), RELN(49), SDC1(5), SDC3(2), SV2A(5), SV2B(8), SV2C(11), THBS1(4), THBS2(16), THBS3(6), THBS4(5), TNC(21), TNN(34), TNR(40), TNXB(15), VTN(2), VWF(13)	77840306	1001	184	993	335	118	357	249	124	150	3	0.99	1.00	1.00
171	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), ADRA1A(4), ADRA1B(4), ADRA1D(2), ADRB2(2), ADRB3(3), ANXA6(1), ARRB1(2), ARRB2(2), ATP1A4(15), ATP1B3(1), ATP2A2(6), ATP2A3(4), ATP2B1(9), ATP2B2(11), ATP2B3(11), CACNA1A(10), CACNA1B(15), CACNA1C(26), CACNA1D(17), CACNA1E(50), CACNA1S(11), CACNB1(1), CALM1(2), CALR(1), CAMK1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), CASQ1(3), CASQ2(4), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), FXYD2(1), GJA1(6), GJA4(1), GJA5(3), GJB1(3), GJB3(1), GJB4(4), GJB5(3), GJB6(1), GNA11(1), GNAI3(1), GNAO1(2), GNAQ(2), GNAZ(4), GNB1(2), GNB3(2), GNB4(1), GNB5(1), GNG12(2), GNG2(4), GNG3(2), GNG4(1), GNGT1(2), GRK4(6), GRK5(8), GRK6(1), ITPR1(11), ITPR2(25), ITPR3(6), KCNB1(16), KCNJ3(15), KCNJ5(1), MIB1(6), NME7(4), PEA15(3), PKIA(1), PKIB(1), PLCB3(4), PLN(1), PRKACB(3), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(16), RGS1(7), RGS11(1), RGS16(1), RGS18(5), RGS2(1), RGS20(5), RGS3(9), RGS4(4), RGS5(5), RGS6(2), RGS7(13), RGS9(5), RYR1(52), RYR2(166), RYR3(53), SLC8A1(26), SLC8A3(7), USP5(3)	65335303	945	183	936	334	116	313	264	134	114	4	0.97	1.00	1.00
172	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	119	ABL1(2), ABLIM1(5), ABLIM2(2), ABLIM3(8), ARHGEF12(11), CDC42(2), CDK5(1), CFL2(2), CXCL12(1), CXCR4(3), DCC(22), DPYSL2(1), DPYSL5(4), EFNA1(1), EFNA2(1), EFNA3(1), EFNB1(1), EFNB2(1), EPHA1(10), EPHA2(2), EPHA3(25), EPHA4(9), EPHA5(26), EPHA8(7), EPHB2(7), EPHB3(6), EPHB4(7), EPHB6(24), FES(1), FYN(3), GNAI1(3), GNAI3(1), GSK3B(2), HRAS(1), ITGB1(3), L1CAM(14), LIMK2(1), LRRC4C(16), MAPK3(1), MET(12), NCK1(3), NCK2(3), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NGEF(4), NRP1(4), NTN1(1), NTN4(5), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PLXNA1(9), PLXNA2(14), PLXNA3(8), PLXNB1(4), PLXNB2(8), PLXNB3(3), PLXNC1(11), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PTK2(11), RAC2(1), RASA1(3), RGS3(9), RHOA(1), RHOD(1), ROBO1(14), ROBO2(21), ROBO3(12), ROCK1(10), ROCK2(4), SEMA3B(2), SEMA3C(6), SEMA3D(20), SEMA3E(6), SEMA3F(3), SEMA3G(4), SEMA4A(3), SEMA4C(1), SEMA4D(5), SEMA4F(5), SEMA4G(3), SEMA5A(24), SEMA5B(9), SEMA6A(10), SEMA6B(5), SEMA6C(9), SEMA6D(21), SEMA7A(7), SLIT1(16), SLIT2(28), SLIT3(16), SRGAP1(10), SRGAP2(4), SRGAP3(10), UNC5A(5), UNC5B(8), UNC5C(11), UNC5D(17)	64460981	760	180	756	262	110	228	199	112	110	1	0.94	1.00	1.00
173	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	127	ACTG1(2), ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), AKT2(2), AKT3(5), AMOTL1(7), ASH1L(22), CASK(3), CDC42(2), CDK4(2), CGN(7), CLDN1(3), CLDN10(1), CLDN11(3), CLDN14(4), CLDN15(1), CLDN16(3), CLDN17(7), CLDN18(3), CLDN2(1), CLDN20(1), CLDN4(2), CLDN8(5), CLDN9(2), CSDA(2), CTNNA1(3), CTNNA3(11), CTNNB1(11), CTTN(3), EPB41(1), EPB41L1(9), EPB41L2(9), EPB41L3(17), EXOC3(3), EXOC4(6), F11R(2), GNAI1(3), GNAI3(1), HCLS1(6), HRAS(1), IGSF5(3), INADL(25), JAM2(6), LLGL1(1), LLGL2(2), MAGI1(16), MAGI2(15), MAGI3(4), MLLT4(4), MPDZ(7), MPP5(1), MRAS(1), MYH1(36), MYH10(6), MYH11(15), MYH13(18), MYH14(2), MYH15(15), MYH2(37), MYH3(11), MYH4(24), MYH6(21), MYH7(20), MYH7B(6), MYH8(28), MYH9(8), MYL2(2), MYL5(1), MYL7(3), MYLPF(1), OCLN(1), PARD3(6), PARD6B(3), PPM1J(1), PPP2CA(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(3), PPP2R2A(4), PPP2R2B(5), PPP2R2C(3), PPP2R3A(1), PPP2R3B(4), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCI(7), PRKCQ(4), PRKCZ(2), PTEN(8), RAB13(2), RAB3B(1), RHOA(1), RRAS(1), RRAS2(1), SPTAN1(12), SRC(2), SYMPK(7), TJAP1(2), TJP1(10), TJP2(4), TJP3(2), VAPA(1), YES1(3), ZAK(3)	66031921	679	174	670	243	112	207	183	99	77	1	0.98	1.00	1.00
174	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(4), ACTA2(1), ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), ARRB1(2), ARRB2(2), ATF2(5), ATF4(1), ATP2A2(6), ATP2A3(4), CALCA(2), CALM1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CNN1(2), CORIN(12), CRH(1), CRHR1(1), DGKZ(3), ETS2(3), FOS(1), GABPA(1), GBA2(2), GJA1(6), GNAQ(2), GNB1(2), GNB3(2), GNB4(1), GNB5(1), GNG12(2), GNG2(4), GNG3(2), GNG4(1), GNGT1(2), GRK4(6), GRK5(8), GRK6(1), GUCA2B(3), GUCY1A3(6), IGFBP1(3), IGFBP2(1), IGFBP3(2), IGFBP4(1), ITPR1(11), ITPR2(25), ITPR3(6), MIB1(6), MYL2(2), MYL4(1), MYLK2(3), NFKB1(3), NOS1(9), NOS3(2), OXT(1), OXTR(2), PDE4B(7), PDE4D(4), PKIA(1), PKIB(1), PLCB3(4), PLCD1(2), PLCG1(5), PLCG2(9), PRKACB(3), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(16), RAMP2(1), RAMP3(2), RGS1(7), RGS11(1), RGS16(1), RGS18(5), RGS2(1), RGS20(5), RGS3(9), RGS4(4), RGS5(5), RGS6(2), RGS7(13), RGS9(5), RYR1(52), RYR2(166), RYR3(53), SLC8A1(26), SP1(1), TNXB(15), USP5(3)	60206161	739	173	734	276	82	240	208	113	93	3	1.00	1.00	1.00
175	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	128	ALCAM(3), CADM1(2), CADM3(5), CD2(3), CD22(6), CD226(8), CD274(3), CD276(1), CD28(1), CD34(4), CD4(3), CD40LG(6), CD58(1), CD6(4), CD80(4), CD86(6), CD8A(2), CD8B(3), CD99(3), CDH1(5), CDH15(5), CDH2(20), CDH3(3), CDH4(9), CDH5(7), CLDN1(3), CLDN10(1), CLDN11(3), CLDN14(4), CLDN15(1), CLDN16(3), CLDN17(7), CLDN18(3), CLDN2(1), CLDN20(1), CLDN4(2), CLDN8(5), CLDN9(2), CNTN1(20), CNTN2(9), CNTNAP1(5), CNTNAP2(41), CTLA4(1), ESAM(1), F11R(2), GLG1(9), HLA-A(2), HLA-B(3), HLA-C(3), HLA-DMA(2), HLA-DMB(1), HLA-DOA(2), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(3), HLA-G(1), ICAM2(2), ICAM3(2), ICOS(2), ICOSLG(1), ITGA4(19), ITGA6(5), ITGA8(24), ITGA9(2), ITGAL(20), ITGAM(14), ITGAV(9), ITGB1(3), ITGB2(2), ITGB7(1), ITGB8(5), JAM2(6), L1CAM(14), MADCAM1(3), MAG(5), MPZ(1), MPZL1(2), NCAM1(8), NCAM2(13), NEGR1(5), NEO1(13), NFASC(11), NLGN1(17), NLGN2(4), NLGN3(3), NRCAM(14), NRXN2(11), NRXN3(18), OCLN(1), PDCD1(1), PDCD1LG2(3), PTPRC(21), PTPRF(4), PTPRM(6), PVRL1(4), SDC1(5), SDC3(2), SELE(6), SELL(4), SELP(14), SELPLG(3), SIGLEC1(7), SPN(3), VCAM1(16), VCAN(34)	49885360	655	167	651	229	91	218	176	98	71	1	0.96	1.00	1.00
176	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	247	ACVR1(4), ACVR1B(5), ACVR2A(3), ACVR2B(4), AMH(1), AMHR2(2), BMP2(1), BMP7(4), BMPR1A(1), BMPR1B(5), BMPR2(2), CCL13(2), CCL14(2), CCL15(3), CCL17(1), CCL18(1), CCL20(1), CCL22(1), CCL23(1), CCL25(1), CCL28(4), CCL3(1), CCL4(1), CCL7(1), CCR1(2), CCR2(5), CCR3(2), CCR4(2), CCR5(1), CCR6(2), CCR8(6), CD27(1), CD40LG(6), CNTF(1), CNTFR(3), CSF1(1), CSF1R(6), CSF2RA(5), CSF2RB(5), CSF3R(4), CX3CL1(3), CX3CR1(5), CXCL1(2), CXCL12(1), CXCL16(1), CXCL5(1), CXCL6(4), CXCL9(3), CXCR3(1), CXCR4(3), CXCR6(1), EDA(3), EDA2R(2), EDAR(3), EGF(9), EPO(3), EPOR(1), FAS(3), FASLG(4), FLT1(21), FLT3(10), FLT3LG(2), FLT4(13), GDF5(4), GH1(2), GH2(5), GHR(5), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR2(2), IFNB1(4), IFNG(4), IFNGR1(3), IFNGR2(3), IFNW1(1), IL10(1), IL10RA(4), IL10RB(2), IL12A(3), IL12RB1(3), IL12RB2(12), IL13(1), IL15(2), IL15RA(1), IL17A(4), IL17B(3), IL17RA(3), IL18R1(3), IL18RAP(7), IL19(1), IL1A(3), IL1R1(1), IL1R2(4), IL1RAP(2), IL2(5), IL20RA(3), IL21(1), IL21R(9), IL22(2), IL22RA2(2), IL23R(1), IL24(3), IL25(2), IL28B(2), IL28RA(4), IL2RA(3), IL2RB(5), IL2RG(3), IL3(1), IL3RA(5), IL4(1), IL4R(5), IL5RA(5), IL6R(8), IL7R(7), IL9R(5), INHBB(1), INHBC(1), INHBE(3), KDR(30), KIT(6), LEP(4), LEPR(13), LIF(2), LIFR(5), LTA(2), LTB(1), MET(12), MPL(2), NGFR(2), OSM(2), OSMR(5), PDGFB(1), PDGFRA(17), PDGFRB(8), PLEKHO2(2), PRL(1), PRLR(9), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(7), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF18(1), TNFRSF19(1), TNFRSF1B(1), TNFRSF21(2), TNFRSF25(1), TNFRSF4(2), TNFRSF8(2), TNFRSF9(4), TNFSF10(1), TNFSF11(1), TNFSF13B(1), TNFSF14(1), TNFSF15(1), TNFSF18(1), TNFSF4(3), TNFSF8(1), TNFSF9(1), TPO(16), TSLP(3), VEGFA(1), VEGFC(11), XCL1(3), XCL2(5), XCR1(1)	59451148	631	166	628	210	62	203	168	115	83	0	0.92	1.00	1.00
177	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(23), APC2(2), AXIN1(3), AXIN2(2), BTRC(9), CACYBP(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CCND1(2), CCND2(1), CCND3(1), CER1(2), CHD8(13), CREBBP(4), CSNK1A1(1), CSNK1A1L(5), CSNK1E(6), CTNNB1(11), CUL1(6), CXXC4(3), DAAM1(3), DAAM2(4), DKK1(2), DKK2(4), DKK4(2), DVL1(1), DVL2(1), DVL3(5), EP300(2), FOSL1(3), FZD1(3), FZD10(8), FZD2(3), FZD3(4), FZD4(5), FZD5(1), FZD7(3), FZD9(2), GSK3B(2), LEF1(8), LRP5(5), LRP6(10), MAP3K7(5), MAPK10(5), MAPK8(3), MAPK9(6), MMP7(4), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NKD1(6), NKD2(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PORCN(3), PPARD(2), PPP2CA(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(3), PPP2R2A(4), PPP2R2B(5), PPP2R2C(3), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRICKLE1(5), PRICKLE2(2), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), PSEN1(1), RAC2(1), RHOA(1), ROCK1(10), ROCK2(4), RUVBL1(2), SENP2(3), SFRP1(1), SFRP2(2), SFRP4(3), SFRP5(1), SKP1(2), SMAD2(2), SMAD3(3), SMAD4(8), SOX17(1), TBL1XR1(5), TCF7(1), TCF7L1(2), TCF7L2(3), VANGL1(3), VANGL2(8), WNT1(3), WNT10A(4), WNT10B(2), WNT11(2), WNT16(2), WNT2(4), WNT2B(2), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(3), WNT6(1), WNT7A(6), WNT7B(2), WNT8A(3), WNT8B(2), WNT9A(2), WNT9B(5)	55203198	477	163	474	141	81	114	148	61	73	0	0.28	1.00	1.00
178	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(1), ACTN2(23), ACTN3(3), ACTN4(2), DMD(41), FAM48A(2), MYBPC1(6), MYBPC2(3), MYBPC3(5), MYH3(11), MYH6(21), MYH7(20), MYH8(28), MYL1(3), MYL2(2), MYL3(2), MYL4(1), MYOM1(4), NEB(36), TMOD1(3), TNNC2(2), TNNI1(2), TNNI2(4), TNNI3(2), TNNT2(4), TNNT3(3), TPM1(1), TPM2(2), TPM3(3), TPM4(1), TTN(375), VIM(2)	47583223	622	161	616	216	63	194	177	121	58	9	1.00	1.00	1.00
179	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	160	ADORA1(1), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA1B(4), ADRA1D(2), ADRA2A(1), ADRA2C(3), ADRB2(2), ADRB3(3), AGTR1(5), AGTR2(2), AVPR1A(6), AVPR1B(3), AVPR2(4), BDKRB1(1), BDKRB2(1), BRS3(8), C3AR1(5), CCBP2(2), CCKAR(7), CCKBR(11), CCR1(2), CCR2(5), CCR3(2), CCR4(2), CCR5(1), CCR6(2), CCR8(6), CCRL1(2), CCRL2(2), CHML(7), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), CNR1(4), CNR2(1), CX3CR1(5), CXCR3(1), CXCR4(3), DRD1(3), DRD2(9), DRD3(9), DRD5(9), EDNRB(6), F2R(4), F2RL1(1), F2RL2(5), F2RL3(2), FPR1(4), FSHR(20), GALR1(3), GALR2(1), GALT(2), GHSR(4), GNB2L1(2), GPR17(3), GPR173(1), GPR27(1), GPR37(5), GPR37L1(2), GPR4(5), GPR50(7), GPR6(2), GPR63(4), GPR77(1), GPR83(4), GPR85(8), GPR87(2), GRPR(5), HCRTR1(1), HCRTR2(13), HRH1(6), HRH2(6), HRH3(1), HTR1A(13), HTR1B(5), HTR1D(1), HTR1E(9), HTR1F(4), HTR2A(3), HTR2B(2), HTR2C(6), HTR5A(11), HTR6(5), HTR7(3), LHCGR(6), LTB4R(2), MAS1(3), MC3R(9), MC4R(1), MC5R(10), MLNR(1), MTNR1A(5), MTNR1B(6), NMBR(6), NMUR1(4), NMUR2(11), NPY1R(9), NPY2R(6), NPY5R(9), NTSR1(5), NTSR2(1), OPN1SW(3), OPN3(2), OPRD1(1), OPRK1(5), OPRL1(5), OPRM1(4), OR10A5(9), OR11A1(3), OR12D3(1), OR1C1(13), OR1F1(3), OR1Q1(5), OR2H1(5), OR5V1(2), OR7A5(2), OR7C1(3), OR8B8(7), OXTR(2), P2RY1(5), P2RY10(10), P2RY12(4), P2RY14(2), P2RY6(1), PPYR1(2), PTAFR(2), PTGDR(3), PTGER2(2), PTGER4(7), PTGFR(6), PTGIR(2), RHO(1), RRH(2), SSTR1(3), SSTR3(2), SSTR4(5), SUCNR1(1), TRHR(4)	41275189	616	160	613	258	61	221	172	108	53	1	0.99	1.00	1.00
180	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	107	ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), ARHGAP5(7), BCAR1(2), CD99(3), CDC42(2), CDH5(7), CLDN1(3), CLDN10(1), CLDN11(3), CLDN14(4), CLDN15(1), CLDN16(3), CLDN17(7), CLDN18(3), CLDN2(1), CLDN20(1), CLDN4(2), CLDN8(5), CLDN9(2), CTNNA1(3), CTNNA3(11), CTNNB1(11), CTNND1(9), CXCL12(1), CXCR4(3), CYBB(7), ESAM(1), EZR(1), F11R(2), GNAI1(3), GNAI3(1), GRLF1(9), ITGA4(19), ITGAL(20), ITGAM(14), ITGB1(3), ITGB2(2), ITK(7), JAM2(6), MAPK11(1), MAPK14(1), MLLT4(4), MMP2(13), MMP9(10), MSN(1), MYL2(2), MYL5(1), MYL7(3), MYLPF(1), NCF1(1), NCF2(2), NCF4(2), NOX1(3), NOX3(5), OCLN(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PLCG1(5), PLCG2(9), PRKCA(7), PRKCG(10), PTK2(11), PTK2B(8), PXN(1), RAC2(1), RAP1A(2), RAP1B(1), RAPGEF3(2), RAPGEF4(6), RHOA(1), RHOH(2), ROCK1(10), ROCK2(4), SIPA1(1), THY1(1), TXK(5), VASP(3), VAV1(1), VAV2(3), VAV3(14), VCAM1(16), VCL(2)	41847460	440	160	434	143	58	138	125	72	47	0	0.76	1.00	1.00
181	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	89	ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), CSNK1D(2), DRD1(3), DRD2(9), EGF(9), GJA1(6), GJD2(2), GNA11(1), GNAI1(3), GNAI3(1), GNAQ(2), GNAS(7), GRB2(4), GRM1(26), GRM5(13), GUCY1A2(7), GUCY1A3(6), GUCY1B3(5), GUCY2C(7), GUCY2D(1), GUCY2F(12), HRAS(1), HTR2A(3), HTR2B(2), HTR2C(6), ITPR1(11), ITPR2(25), ITPR3(6), MAP2K1(6), MAP2K2(1), MAP3K2(5), MAPK3(1), MAPK7(5), NPR1(6), NPR2(2), PDGFA(6), PDGFB(1), PDGFD(4), PDGFRA(17), PDGFRB(8), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKG1(3), PRKG2(7), PRKX(3), RAF1(3), SOS1(12), SOS2(6), SRC(2), TJP1(10), TUBA1A(3), TUBA1B(1), TUBA1C(3), TUBA3C(12), TUBA3D(9), TUBA3E(2), TUBA4A(3), TUBA8(1), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB4(5), TUBB4Q(12), TUBB8(7)	44371956	513	158	511	189	63	154	152	84	60	0	0.97	1.00	1.00
182	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	71	ARAF(3), CACNA1A(10), CRH(1), CRHR1(1), GNA11(1), GNA12(1), GNA13(5), GNAI1(3), GNAI3(1), GNAO1(2), GNAQ(2), GNAS(7), GNAZ(4), GRIA1(12), GRIA2(15), GRIA3(11), GRID2(22), GRM1(26), GRM5(13), GUCY1A2(7), GUCY1A3(6), GUCY1B3(5), GUCY2C(7), GUCY2D(1), GUCY2F(12), HRAS(1), IGF1(5), IGF1R(10), ITPR1(11), ITPR2(25), ITPR3(6), LYN(4), MAP2K1(6), MAP2K2(1), MAPK3(1), NOS1(9), NOS3(2), NPR1(6), NPR2(2), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PPP2CA(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(3), PPP2R2A(4), PPP2R2B(5), PPP2R2C(3), PRKCA(7), PRKCG(10), PRKG1(3), PRKG2(7), RAF1(3), RYR1(52)	37335473	443	157	441	146	56	129	123	68	66	1	0.81	1.00	1.00
183	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	127	ACACA(10), ACACB(11), AKT2(2), AKT3(5), ARAF(3), CALM1(2), CALML3(3), CBL(9), CBLB(5), CBLC(1), CRKL(2), ELK1(2), EXOC7(2), FASN(4), FBP2(1), FLOT1(2), FLOT2(1), FOXO1(3), G6PC(1), G6PC2(2), GCK(4), GRB2(4), GSK3B(2), GYS1(2), GYS2(3), HRAS(1), IKBKB(3), INPP5D(4), INSR(1), IRS1(15), IRS2(3), IRS4(17), LIPE(2), MAP2K1(6), MAP2K2(1), MAPK10(5), MAPK3(1), MAPK8(3), MAPK9(6), MKNK1(2), MKNK2(1), PCK2(3), PDE3A(13), PDE3B(9), PDPK1(1), PFKL(2), PFKM(5), PFKP(3), PHKA1(4), PHKA2(10), PHKB(7), PHKG1(1), PHKG2(3), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PKLR(11), PKM2(4), PPARGC1A(12), PPP1CA(2), PPP1CB(1), PPP1CC(1), PPP1R3A(12), PPP1R3B(1), PPP1R3C(1), PPP1R3D(4), PRKAA1(4), PRKAB1(3), PRKACB(3), PRKACG(1), PRKAG2(4), PRKAG3(4), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCI(7), PRKCZ(2), PRKX(3), PTPN1(1), PTPRF(4), PYGB(1), PYGL(3), PYGM(6), RAF1(3), RAPGEF1(1), RHEB(4), RPS6KB1(2), RPS6KB2(2), SHC1(2), SHC2(1), SHC3(4), SHC4(4), SOCS4(1), SORBS1(7), SOS1(12), SOS2(6), SREBF1(2), TSC1(9), TSC2(4)	54178194	428	155	422	163	74	109	127	65	53	0	0.97	1.00	1.00
184	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	92	ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), ATF4(1), CACNA1C(26), CACNA1D(17), CACNA1F(10), CACNA1S(11), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CDC42(2), CGA(1), ELK1(2), FSHB(1), GNA11(1), GNAQ(2), GNAS(7), GNRHR(2), GRB2(4), HBEGF(1), HRAS(1), ITPR1(11), ITPR2(25), ITPR3(6), LHB(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K1(4), MAP3K2(5), MAP3K3(4), MAP3K4(14), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK7(5), MAPK8(3), MAPK9(6), MMP14(3), MMP2(13), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLD1(9), PLD2(5), PRKACB(3), PRKACG(1), PRKCA(7), PRKCD(1), PRKX(3), PTK2B(8), RAF1(3), SOS1(12), SOS2(6), SRC(2)	42849335	454	155	451	151	73	123	135	65	58	0	0.76	1.00	1.00
185	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADA(2), ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), ADSSL1(1), AK2(3), AK5(10), AK7(7), ALLC(6), AMPD1(6), AMPD2(3), AMPD3(3), ATIC(3), CANT1(3), DCK(2), DGUOK(2), ENPP1(6), ENPP3(12), ENTPD1(4), ENTPD2(2), ENTPD4(2), ENTPD6(3), FHIT(1), GART(4), GDA(6), GMPR(3), GMPS(8), GUCY1A2(7), GUCY1A3(6), GUCY1B3(5), GUCY2C(7), GUCY2D(1), GUCY2F(12), GUK1(2), HPRT1(1), IMPDH1(4), IMPDH2(1), ITPA(1), NME6(1), NME7(4), NPR1(6), NPR2(2), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5E(2), NT5M(1), NUDT2(3), NUDT5(2), NUDT9(2), PAPSS1(3), PAPSS2(4), PDE10A(16), PDE11A(11), PDE1A(8), PDE1C(17), PDE2A(5), PDE3B(9), PDE4A(4), PDE4B(7), PDE4C(2), PDE4D(4), PDE5A(1), PDE6D(1), PDE6G(2), PDE7A(2), PDE7B(3), PDE8A(3), PDE8B(5), PDE9A(2), PFAS(4), PKLR(11), PKM2(4), PNPT1(5), POLA1(6), POLA2(2), POLD1(2), POLD2(2), POLD3(3), POLE(19), POLE2(1), POLR1A(8), POLR1B(10), POLR1D(2), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLR3A(12), POLR3B(15), POLR3G(1), POLR3H(1), PPAT(5), PRIM1(3), PRPS1(3), PRPS1L1(3), PRPS2(2), PRUNE(5), RFC5(1), RRM1(5), RRM2(4), XDH(11)	56200264	558	154	553	193	76	155	169	89	69	0	0.93	1.00	1.00
186	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	63	ADCY1(10), ADCY8(22), ARAF(3), ATF4(1), CACNA1C(26), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), CREBBP(4), EP300(2), GNAQ(2), GRIA1(12), GRIA2(15), GRIN1(2), GRIN2A(26), GRIN2B(22), GRIN2C(3), GRIN2D(6), GRM1(26), GRM5(13), HRAS(1), ITPR1(11), ITPR2(25), ITPR3(6), MAP2K1(6), MAP2K2(1), MAPK3(1), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PPP1CA(2), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R1A(2), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), RAF1(3), RAP1A(2), RAP1B(1), RAPGEF3(2), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5)	33516898	373	154	372	125	51	112	101	58	51	0	0.81	1.00	1.00
187	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(1), ALG10(9), ALG10B(6), ALG12(2), ALG13(9), ALG14(2), ALG2(5), ALG3(5), ALG8(2), ALG9(3), B3GNT1(3), B3GNT2(1), B3GNT6(3), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), B4GALT5(3), C1GALT1(2), C1GALT1C1(2), CHPF(3), CHST1(10), CHST11(1), CHST12(5), CHST13(3), CHST2(4), CHST3(2), CHST6(3), CHSY1(2), DAD1(1), DDOST(1), DPAGT1(1), EXT1(3), EXT2(7), EXTL1(3), EXTL3(5), FUT11(2), FUT8(4), GALNT1(3), GALNT10(3), GALNT11(2), GALNT12(4), GALNT13(15), GALNT14(10), GALNT2(4), GALNT3(4), GALNT4(4), GALNT5(6), GALNT6(2), GALNT7(5), GALNT8(6), GALNT9(1), GALNTL1(4), GALNTL2(6), GALNTL4(6), GALNTL5(5), GANAB(3), GCNT1(4), GCNT3(3), GCNT4(3), HS3ST1(2), HS3ST2(2), HS3ST3A1(4), HS3ST3B1(1), HS3ST5(9), HS6ST1(1), HS6ST2(1), HS6ST3(5), MAN1A2(9), MAN1B1(3), MAN1C1(2), MAN2A1(11), MGAT1(2), MGAT3(4), MGAT4A(3), MGAT4B(1), MGAT5(6), MGAT5B(7), NDST1(2), NDST2(7), NDST3(8), NDST4(13), OGT(6), RPN2(4), ST3GAL1(3), ST3GAL2(3), ST3GAL3(1), ST3GAL4(2), ST6GALNAC1(3), STT3B(2), UST(1), WBSCR17(16), XYLT1(19)	37876371	389	152	385	150	63	110	111	63	41	1	0.99	1.00	1.00
188	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT3(5), BCAR1(2), CAPN10(4), CAPN11(9), CAPN2(3), CAPN3(6), CAPN5(10), CAPN6(10), CAPN7(5), CAPN9(6), CAV3(2), CDC42(2), DOCK1(7), FYN(3), GIT2(3), GRB2(4), ILK(1), ITGA10(7), ITGA11(10), ITGA2(11), ITGA2B(4), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), ITGAD(17), ITGAE(9), ITGAL(20), ITGAM(14), ITGAV(9), ITGAX(20), ITGB1(3), ITGB2(2), ITGB3(4), ITGB4(4), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(5), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K6(1), MAPK10(5), MAPK4(6), MAPK6(1), MAPK7(5), MYLK2(3), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PDPK1(1), PIK3R2(1), PTK2(11), PXN(1), RAC2(1), RAP1B(1), RAPGEF1(1), RHO(1), ROCK1(10), ROCK2(4), SDCCAG8(6), SHC1(2), SHC3(4), SORBS1(7), SOS1(12), SRC(2), TLN1(13), TNS1(14), VASP(3), VAV2(3), VAV3(14), VCL(2), ZYX(2)	46314792	458	150	456	170	67	137	116	71	65	2	0.99	1.00	1.00
189	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ABL1(2), ACTN1(2), ACTR2(2), ACTR3(1), AKT2(2), AKT3(5), ANGPTL2(4), ARHGEF6(9), ARHGEF7(6), BCAR1(2), CDC42(2), CSE1L(3), DOCK1(7), EPHB2(7), FYN(3), GRB2(4), GRB7(3), GRLF1(9), ILK(1), ITGA1(9), ITGA10(7), ITGA11(10), ITGA2(11), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), MAP2K4(3), MAP2K7(2), MAP3K11(7), MAPK10(5), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), MRAS(1), MYLK(16), MYLK2(3), P4HB(4), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PIK3CA(11), PIK3CB(7), PKLR(11), PLCG1(5), PLCG2(9), PTEN(8), PTK2(11), RAF1(3), RALA(2), RHO(1), ROCK1(10), ROCK2(4), SHC1(2), SOS1(12), SOS2(6), SRC(2), TLN1(13), TLN2(15), VASP(3), WAS(3), ZYX(2)	41364728	407	150	400	120	67	106	118	59	57	0	0.35	1.00	1.00
190	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	107	ABL1(2), ANAPC1(5), ANAPC10(1), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(3), ANAPC7(4), ATM(22), ATR(17), BUB1(4), BUB1B(8), BUB3(1), CCNA1(2), CCNA2(4), CCNB1(1), CCNB2(1), CCNB3(13), CCND1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(1), CDC14A(7), CDC14B(1), CDC16(3), CDC20(3), CDC23(1), CDC25A(4), CDC25B(1), CDC25C(3), CDC27(3), CDC6(1), CDC7(3), CDK2(4), CDK4(2), CDK6(3), CDK7(3), CDKN1A(1), CDKN1B(3), CDKN2D(1), CHEK1(6), CHEK2(2), CREBBP(4), CUL1(6), DBF4(3), E2F1(3), E2F3(1), EP300(2), ESPL1(4), FZR1(2), GADD45A(1), GSK3B(2), HDAC1(3), HDAC2(8), MAD1L1(5), MAD2L1(3), MCM2(6), MCM3(5), MCM4(6), MCM5(3), MCM6(10), MCM7(4), MDM2(2), ORC1L(4), ORC2L(4), ORC3L(1), ORC4L(1), ORC5L(5), ORC6L(1), PCNA(1), PKMYT1(2), PLK1(3), PRKDC(23), PTTG1(1), PTTG2(2), RB1(13), RBL1(7), RBL2(2), SKP1(2), SKP2(4), SMAD2(2), SMAD3(3), SMAD4(8), SMC1A(4), SMC1B(6), TFDP1(3), TGFB1(2), TGFB2(8), TGFB3(1), WEE1(3), YWHAG(2)	46730885	356	148	354	89	51	88	111	53	53	0	0.13	1.00	1.00
191	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	78	AGL(13), AMY2A(4), AMY2B(16), ASCC3(10), ATP13A2(5), DDX18(3), DDX19A(1), DDX23(8), DDX4(6), DDX41(1), DDX47(1), DDX50(6), DDX52(3), DDX54(2), DDX55(1), DDX56(1), DHX58(1), ENPP1(6), ENPP3(12), ENTPD7(3), EP400(14), ERCC2(3), ERCC3(5), G6PC(1), G6PC2(2), GAA(2), GANC(1), GBA(3), GBE1(2), GCK(4), GPI(3), GUSB(4), GYS1(2), GYS2(3), HK1(3), HK2(9), HK3(12), IFIH1(6), LYZL1(4), MGAM(30), MOV10L1(9), NUDT5(2), NUDT8(1), PGM1(2), PGM3(4), PYGB(1), PYGL(3), PYGM(6), RAD54B(8), RAD54L(1), RUVBL2(3), SETX(17), SI(63), SKIV2L2(10), SMARCA2(10), SMARCA5(1), TREH(1), UGDH(4), UGP2(1), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8), UXS1(4)	41912038	452	147	449	145	62	157	121	66	45	1	0.86	1.00	1.00
192	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT2(2), AKT3(5), CBL(9), CBLB(5), CBLC(1), CCND1(2), CCND2(1), CCND3(1), CNTF(1), CNTFR(3), CREBBP(4), CSF2RA(5), CSF2RB(5), CSF3R(4), EP300(2), EPO(3), EPOR(1), GH1(2), GH2(5), GHR(5), GRB2(4), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR2(2), IFNB1(4), IFNG(4), IFNGR1(3), IFNGR2(3), IFNW1(1), IL10(1), IL10RA(4), IL10RB(2), IL12A(3), IL12RB1(3), IL12RB2(12), IL13(1), IL13RA2(3), IL15(2), IL15RA(1), IL19(1), IL2(5), IL20RA(3), IL21(1), IL21R(9), IL22(2), IL22RA2(2), IL23R(1), IL24(3), IL28B(2), IL28RA(4), IL2RA(3), IL2RB(5), IL2RG(3), IL3(1), IL3RA(5), IL4(1), IL4R(5), IL5RA(5), IL6R(8), IL7R(7), IL9R(5), IRF9(2), JAK1(8), JAK2(4), JAK3(5), LEP(4), LEPR(13), LIF(2), LIFR(5), MPL(2), OSM(2), OSMR(5), PIAS1(2), PIAS2(5), PIAS3(6), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PRL(1), PRLR(9), PTPN6(3), SOCS4(1), SOCS5(2), SOS1(12), SOS2(6), SPRED1(1), SPRED2(2), SPRY1(1), SPRY2(2), SPRY3(5), SPRY4(3), STAM(6), STAM2(4), STAT1(4), STAT2(5), STAT3(8), STAT4(6), STAT5A(3), STAT5B(4), STAT6(2), TPO(16), TSLP(3), TYK2(2)	49576210	450	146	445	165	45	134	129	87	55	0	0.99	1.00	1.00
193	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(12), ABCA10(12), ABCA12(21), ABCA13(44), ABCA2(6), ABCA3(6), ABCA4(21), ABCA5(7), ABCA6(10), ABCA7(6), ABCA8(16), ABCA9(11), ABCB1(20), ABCB10(8), ABCB11(15), ABCB4(17), ABCB5(27), ABCB6(3), ABCB7(3), ABCB8(5), ABCB9(3), ABCC1(6), ABCC10(3), ABCC11(17), ABCC12(18), ABCC2(5), ABCC3(7), ABCC4(8), ABCC5(11), ABCC6(3), ABCC8(11), ABCC9(25), ABCD1(1), ABCD2(9), ABCD3(5), ABCD4(2), ABCG1(3), ABCG2(5), ABCG4(6), ABCG5(10), ABCG8(6), CFTR(6), TAP2(7)	40968100	447	145	443	143	62	132	116	76	60	1	0.56	1.00	1.00
194	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), AK2(3), AK5(10), ALLC(6), AMPD1(6), AMPD2(3), AMPD3(3), ATIC(3), ATP5A1(3), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP5G3(2), CANT1(3), DCK(2), DGUOK(2), ENPP1(6), ENPP3(12), ENTPD1(4), ENTPD2(2), FHIT(1), GART(4), GDA(6), GMPS(8), GUCY1A2(7), GUCY1A3(6), GUCY1B3(5), GUCY2C(7), GUCY2D(1), GUCY2F(12), GUK1(2), HPRT1(1), IMPDH1(4), IMPDH2(1), ITPA(1), NPR1(6), NPR2(2), NT5E(2), NT5M(1), NUDT2(3), PAPSS1(3), PAPSS2(4), PDE1A(8), PDE4A(4), PDE4B(7), PDE4C(2), PDE4D(4), PDE5A(1), PDE6B(4), PDE6C(5), PDE6G(2), PDE7B(3), PDE8A(3), PDE9A(2), PFAS(4), PKLR(11), PKM2(4), POLB(2), POLD1(2), POLD2(2), POLE(19), POLG(11), POLL(2), POLQ(17), POLR1B(10), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLRMT(1), PPAT(5), PRPS1(3), PRPS1L1(3), PRPS2(2), PRUNE(5), RRM1(5), RRM2(4)	44293638	439	144	435	149	65	112	133	71	58	0	0.85	1.00	1.00
195	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(2), CALML3(3), CDIPT(1), CDS1(2), CDS2(3), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKI(23), DGKZ(3), IMPA1(1), IMPA2(1), INPP1(3), INPP4A(5), INPP4B(14), INPP5A(3), INPP5B(2), INPP5D(4), INPPL1(8), ITGB1BP3(2), ITPK1(1), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), OCRL(6), PI4KA(7), PI4KB(4), PIK3C2A(10), PIK3C2B(7), PIK3C2G(9), PIK3C3(7), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PIP4K2A(5), PIP4K2B(2), PIP4K2C(3), PIP5K1A(5), PIP5K1B(7), PIP5K1C(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCD3(2), PLCD4(3), PLCE1(14), PLCG1(5), PLCG2(9), PLCZ1(3), PRKCA(7), PRKCG(10), PTEN(8), PTPMT1(1), SYNJ1(4), SYNJ2(3)	43347410	402	143	396	121	54	120	109	54	64	1	0.56	1.00	1.00
196	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT2(2), AKT3(5), BCL10(1), CARD11(17), CBL(9), CBLB(5), CBLC(1), CD28(1), CD3D(2), CD4(3), CD40LG(6), CD8A(2), CD8B(3), CDC42(2), CDK4(2), CHUK(3), CTLA4(1), FOS(1), FYN(3), GRAP2(5), GRB2(4), HRAS(1), ICOS(2), IFNG(4), IKBKB(3), IL10(1), IL2(5), IL4(1), ITK(7), LAT(3), LCK(5), LCP2(6), MALT1(6), MAP3K14(1), MAP3K8(2), NCK1(3), NCK2(3), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PDCD1(1), PDK1(4), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PLCG1(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKCQ(4), PTPN6(3), PTPRC(21), RASGRP1(2), RHOA(1), SOS1(12), SOS2(6), TEC(5), VAV1(1), VAV2(3), VAV3(14), ZAP70(4)	34339695	349	143	344	113	49	98	104	45	53	0	0.75	1.00	1.00
197	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	73	ACP1(2), ACTG1(2), ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), ACVR1B(5), ACVR1C(3), BAIAP2(2), CDC42(2), CDH1(5), CREBBP(4), CTNNA1(3), CTNNA3(11), CTNNB1(11), CTNND1(9), EP300(2), ERBB2(10), FARP2(3), FER(6), FGFR1(5), FYN(3), IGF1R(10), INSR(1), IQGAP1(5), LEF1(8), LMO7(10), MAP3K7(5), MAPK3(1), MET(12), MLLT4(4), PARD3(6), PTPN1(1), PTPN6(3), PTPRB(30), PTPRF(4), PTPRJ(5), PTPRM(6), PVRL1(4), PVRL4(3), RAC2(1), RHOA(1), SMAD2(2), SMAD3(3), SMAD4(8), SNAI1(3), SNAI2(4), SORBS1(7), SRC(2), SSX2IP(2), TCF7(1), TCF7L1(2), TCF7L2(3), TGFBR1(2), TGFBR2(2), TJP1(10), VCL(2), WAS(3), WASF1(8), WASF2(1), WASF3(4), WASL(5), YES1(3)	39743408	315	142	307	111	49	85	81	49	51	0	0.92	1.00	1.00
198	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(14), BDKRB1(1), BDKRB2(1), C1QA(1), C1QB(2), C1QC(3), C1R(1), C1S(1), C2(3), C3(7), C3AR1(5), C4BPA(6), C5(2), C5AR1(4), C6(14), C8A(6), C8B(9), C9(11), CD46(1), CD55(2), CFB(5), CFH(23), CFI(7), CPB2(4), CR1(16), CR2(8), F10(3), F11(8), F12(1), F13A1(13), F13B(16), F2(5), F2R(4), F3(4), F5(23), F7(2), F8(23), F9(8), FGA(9), FGB(13), FGG(2), KLKB1(3), KNG1(3), MASP1(5), MASP2(2), MBL2(1), PLAT(6), PLAU(1), PLAUR(2), PLG(13), PROC(3), PROS1(13), SERPINA1(2), SERPINA5(7), SERPINC1(8), SERPIND1(1), SERPINE1(5), SERPING1(3), TFPI(1), THBD(1), VWF(13)	30740044	384	141	381	127	36	137	95	59	54	3	0.98	1.00	1.00
199	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(4), ACVR1B(5), ACVRL1(4), AURKB(1), BMPR1A(1), BMPR2(2), BUB1(4), CDIPT(1), CDKL1(2), CDKL2(1), CDS1(2), CDS2(3), CLK1(2), CLK2(6), CLK4(6), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKZ(3), IMPA1(1), INPP1(3), INPP4A(5), INPP4B(14), INPP5A(3), INPPL1(8), ITPKA(1), ITPKB(5), MAP3K10(1), MOS(2), NEK1(6), NEK3(4), OCRL(6), PAK4(1), PIK3C2A(10), PIK3C2B(7), PIK3C2G(9), PIK3CA(11), PIK3CB(7), PIK3CG(11), PIM2(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCG1(5), PLCG2(9), PLK3(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(16), PRKG1(3), RAF1(3), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA4(1), RPS6KB1(2), TGFBR1(2), VRK1(2)	38927710	346	140	341	111	48	93	100	48	57	0	0.81	1.00	1.00
200	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	121	ARAF(3), BID(1), CASP3(4), CD244(6), CD48(3), FAS(3), FASLG(4), FCER1G(2), FCGR3A(7), FCGR3B(5), FYN(3), GRB2(4), GZMB(3), HCST(3), HLA-A(2), HLA-B(3), HLA-C(3), HLA-G(1), HRAS(1), ICAM2(2), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR2(2), IFNB1(4), IFNG(4), IFNGR1(3), IFNGR2(3), ITGAL(20), ITGB2(2), KIR2DL1(4), KIR2DL3(2), KIR2DL4(1), KIR3DL1(10), KLRC1(3), KLRC2(3), KLRC3(3), KLRD1(2), KLRK1(2), LAT(3), LCK(5), LCP2(6), MAP2K1(6), MAP2K2(1), MAPK3(1), NCR1(2), NCR3(1), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), PAK1(5), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PLCG1(5), PLCG2(9), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRF1(5), PRKCA(7), PRKCG(10), PTK2B(8), PTPN6(3), RAC2(1), RAF1(3), SH2D1A(1), SH2D1B(1), SH3BP2(3), SHC1(2), SHC2(1), SHC3(4), SHC4(4), SOS1(12), SOS2(6), SYK(3), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(1), ULBP1(1), ULBP2(1), ULBP3(1), VAV1(1), VAV2(3), VAV3(14), ZAP70(4)	37753627	395	139	389	127	58	102	112	74	49	0	0.66	1.00	1.00
201	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	97	ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CREB3L1(1), CREB3L2(4), CREB3L3(1), CREB3L4(1), CREBBP(4), CTNNB1(11), DCT(7), DVL1(1), DVL2(1), DVL3(5), EDN1(1), EDNRB(6), EP300(2), FZD1(3), FZD10(8), FZD2(3), FZD3(4), FZD4(5), FZD5(1), FZD7(3), FZD9(2), GNAI1(3), GNAI3(1), GNAO1(2), GNAQ(2), GNAS(7), GSK3B(2), HRAS(1), KIT(6), LEF1(8), MAP2K1(6), MAP2K2(1), MAPK3(1), MITF(1), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), POMC(1), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), RAF1(3), TCF7(1), TCF7L1(2), TCF7L2(3), TYR(14), TYRP1(4), WNT1(3), WNT10A(4), WNT10B(2), WNT11(2), WNT16(2), WNT2(4), WNT2B(2), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(3), WNT6(1), WNT7A(6), WNT7B(2), WNT8A(3), WNT8B(2), WNT9A(2), WNT9B(5)	37185936	366	136	363	140	54	95	115	54	48	0	0.96	1.00	1.00
202	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	89	ADCY1(10), ADCY2(18), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), AKAP1(4), AKAP10(1), AKAP11(8), AKAP12(5), AKAP3(7), AKAP4(7), AKAP5(1), AKAP6(16), AKAP7(1), AKAP9(23), ARHGEF1(2), CALM1(2), GNA11(1), GNA12(1), GNA13(5), GNAI3(1), GNAO1(2), GNAQ(2), GNAZ(4), GNB1(2), GNB3(2), GNB5(1), GNG12(2), GNG3(2), GNG4(1), GNGT1(2), GNGT2(2), HRAS(1), IL18BP(1), ITPR1(11), KCNJ3(15), PDE1A(8), PDE1B(6), PDE1C(17), PDE4A(4), PDE4B(7), PDE4C(2), PDE4D(4), PDE7A(2), PDE7B(3), PDE8A(3), PDE8B(5), PLCB3(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCI(7), PRKCQ(4), PRKCZ(2), PRKD1(16), PRKD3(5), RHOA(1), RRAS(1), SLC9A1(3), USP5(3)	39748446	372	134	370	132	35	126	104	55	52	0	0.98	1.00	1.00
203	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(4), CD14(1), CD19(2), CD1A(8), CD1B(11), CD1C(9), CD1D(6), CD1E(12), CD2(3), CD22(6), CD33(10), CD34(4), CD36(4), CD38(3), CD3D(2), CD4(3), CD44(2), CD5(4), CD55(2), CD8A(2), CD8B(3), CR1(16), CR2(8), CSF1(1), CSF1R(6), CSF2RA(5), CSF3R(4), DNTT(3), EPO(3), EPOR(1), FCER2(1), FCGR1A(1), FLT3(10), FLT3LG(2), GP5(3), HLA-DRA(3), IL1A(3), IL1R1(1), IL1R2(4), IL2RA(3), IL3(1), IL3RA(5), IL4(1), IL4R(5), IL5RA(5), IL6R(8), IL7R(7), IL9R(5), ITGA1(9), ITGA2(11), ITGA2B(4), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGAM(14), ITGB3(4), KIT(6), MME(8), MS4A1(4), TFRC(6), THPO(1), TPO(16)	28112498	334	134	331	116	42	126	79	50	37	0	0.94	1.00	1.00
204	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(2), ATM(22), BUB1(4), BUB1B(8), BUB3(1), CCNA1(2), CCNA2(4), CCNB1(1), CCNB2(1), CCNB3(13), CCND2(1), CCND3(1), CCNE1(3), CCNH(1), CDAN1(2), CDC14A(7), CDC14B(1), CDC20(3), CDC25A(4), CDC25B(1), CDC25C(3), CDC6(1), CDC7(3), CDH1(5), CDK2(4), CDK4(2), CDKN1A(1), CHEK1(6), CHEK2(2), DTX4(1), E2F1(3), E2F3(1), E2F6(3), EP300(2), ESPL1(4), GADD45A(1), GSK3B(2), HDAC1(3), HDAC2(8), HDAC3(1), HDAC4(11), HDAC5(2), HDAC6(5), HDAC8(2), MAD1L1(5), MAD2L1(3), MCM2(6), MCM3(5), MCM4(6), MCM5(3), MCM6(10), MCM7(4), MDM2(2), MPEG1(3), MPL(2), ORC1L(4), ORC2L(4), ORC3L(1), ORC4L(1), ORC5L(5), ORC6L(1), PCNA(1), PLK1(3), PRKDC(23), PTPRA(4), PTTG1(1), PTTG2(2), RB1(13), RBL1(7), SKP2(4), SMAD4(8), TBC1D8(3), TFDP1(3), TGFB1(2), WEE1(3)	37714468	300	132	299	81	46	86	82	42	44	0	0.25	1.00	1.00
205	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(2), CCKBR(11), CCR2(5), CCR3(2), CCR5(1), CELSR1(8), CELSR2(8), CELSR3(17), CHRM2(17), CHRM3(13), CXCR3(1), EMR2(3), EMR3(5), F2R(4), FSHR(20), GHRHR(5), GNRHR(2), GPR116(5), GPR132(1), GPR133(8), GPR135(1), GPR143(1), GPR17(3), GPR18(2), GPR55(7), GPR56(6), GPR61(4), GPR77(1), GPR84(4), GRM1(26), GRPR(5), HRH4(4), LGR6(11), LPHN2(24), LPHN3(32), NTSR1(5), OR2M4(14), OR8G2(4), PTGFR(6), SMO(5), TAAR5(8), TSHR(10)	23021828	321	132	321	104	31	95	94	61	40	0	0.51	1.00	1.00
206	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	53	ASH1L(22), CTCFL(16), DOT1L(8), EED(4), EHMT1(8), EHMT2(1), EZH1(2), EZH2(8), FBXO11(2), HCFC1(10), HSF4(1), JMJD4(1), KDM6A(2), MEN1(4), MLL(12), MLL2(25), MLL3(55), MLL4(4), MLL5(3), NSD1(11), OGT(6), PAXIP1(3), PPP1CA(2), PPP1CB(1), PPP1CC(1), PRDM2(8), PRDM7(3), PRDM9(32), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), RBBP5(3), SATB1(6), SETD1A(8), SETD7(1), SETD8(2), SETDB1(5), SETDB2(2), SETMAR(1), SMYD3(4), STK38(2), SUV39H1(2), SUV39H2(3), SUV420H1(5), SUZ12(1), WHSC1(4), WHSC1L1(2)	39052286	326	131	324	94	49	95	98	36	45	3	0.48	1.00	1.00
207	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	87	ACVR1(4), ACVR1B(5), ACVR1C(3), ACVR2A(3), ACVR2B(4), ACVRL1(4), AMH(1), AMHR2(2), BMP2(1), BMP4(4), BMP5(4), BMP6(3), BMP7(4), BMP8A(1), BMPR1A(1), BMPR1B(5), BMPR2(2), CHRD(9), COMP(2), CREBBP(4), CUL1(6), DCN(1), EP300(2), FST(2), GDF5(4), GDF6(7), GDF7(1), ID3(1), IFNG(4), INHBB(1), INHBC(1), INHBE(3), LEFTY1(3), LEFTY2(3), LTBP1(28), MAPK3(1), NODAL(1), PITX2(4), PPP2CA(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(3), PPP2R2A(4), PPP2R2B(5), PPP2R2C(3), RBL1(7), RBL2(2), RHOA(1), ROCK1(10), ROCK2(4), RPS6KB1(2), RPS6KB2(2), SKP1(2), SMAD1(3), SMAD2(2), SMAD3(3), SMAD4(8), SMAD5(2), SMAD9(1), SMURF1(3), SMURF2(2), SP1(1), TFDP1(3), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), THBS1(4), THBS2(16), THBS3(6), THBS4(5), ZFYVE16(1), ZFYVE9(5)	33862230	271	129	271	108	38	70	78	43	42	0	1.00	1.00	1.00
208	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	BCL2(1), CABIN1(5), CALM1(2), CAMK2B(3), CAMK4(8), CD69(2), CDKN1A(1), CNR1(4), CREBBP(4), CTLA4(1), EGR2(2), EGR3(1), EP300(2), FCER1A(7), FCGR3A(7), FOS(1), FOSL1(3), GATA3(6), GATA4(4), GRLF1(9), GSK3B(2), HRAS(1), ICOS(2), IFNB1(4), IFNG(4), IL10(1), IL13(1), IL2(5), IL2RA(3), IL3(1), IL4(1), ITK(7), KPNA5(2), MAP2K7(2), MAPK14(1), MAPK8(3), MAPK9(6), MEF2A(2), MEF2B(1), MEF2D(1), MYF5(3), NCK2(3), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB2(6), NFKBIE(1), NUP214(18), OPRD1(1), P2RX7(5), PAK1(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PTPRC(21), SLA(1), SP1(1), SP3(4), TGFB1(2), TRAF2(1), TRPV6(8), VAV1(1), VAV2(3), VAV3(14), XPO5(3)	31344833	265	128	261	96	33	88	68	37	39	0	0.93	1.00	1.00
209	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT2(2), AKT3(5), CASP8(4), CCL3(1), CCL4(1), CD14(1), CD80(4), CD86(6), CHUK(3), CXCL9(3), FADD(1), FOS(1), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR2(2), IFNB1(4), IKBKB(3), IKBKE(5), IL12A(3), IRAK1(3), IRAK4(4), IRF3(1), IRF7(1), LBP(5), LY96(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K7(5), MAP3K8(2), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(6), MYD88(3), NFKB1(3), NFKB2(6), NFKBIA(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), RIPK1(4), STAT1(4), TBK1(2), TICAM1(1), TLR1(4), TLR2(2), TLR4(31), TLR5(1), TLR6(6), TLR7(8), TLR8(6), TLR9(6), TOLLIP(1), TRAF3(3), TRAF6(4)	30930343	277	127	272	99	29	67	84	53	44	0	0.93	1.00	1.00
210	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), BDKRB2(1), CALM1(2), CHRM1(2), CHRNA1(7), FLT1(21), FLT4(13), KDR(30), NOS3(2), PDE2A(5), PDE3A(13), PDE3B(9), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKG1(3), PRKG2(7), RYR2(166), SLC7A1(3), SYT1(3), TNNI1(2)	14213572	305	126	301	85	32	110	71	49	40	3	0.46	1.00	1.00
211	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	80	ABL1(2), ABL2(7), AKT2(2), AKT3(5), ARAF(3), BTC(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CBL(9), CBLB(5), CBLC(1), CDKN1A(1), CDKN1B(3), CRKL(2), EGF(9), ELK1(2), ERBB2(10), ERBB3(3), ERBB4(21), EREG(4), GAB1(2), GRB2(4), GSK3B(2), HBEGF(1), HRAS(1), MAP2K1(6), MAP2K2(1), MAP2K4(3), MAP2K7(2), MAPK10(5), MAPK3(1), MAPK8(3), MAPK9(6), NCK1(3), NCK2(3), NRG1(9), NRG2(2), NRG4(1), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PLCG1(5), PLCG2(9), PRKCA(7), PRKCG(10), PTK2(11), RAF1(3), RPS6KB1(2), RPS6KB2(2), SHC1(2), SHC2(1), SHC3(4), SHC4(4), SOS1(12), SOS2(6), SRC(2), STAT5A(3), STAT5B(4), TGFA(1)	33274158	320	122	313	97	51	89	86	47	47	0	0.48	1.00	1.00
212	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	67	ACACB(11), ACSL1(8), ACSL3(3), ACSL4(2), ACSL5(1), ACSL6(7), ADIPOQ(4), ADIPOR1(3), ADIPOR2(1), AKT2(2), AKT3(5), CAMKK1(2), CAMKK2(1), CD36(4), CHUK(3), CPT1A(7), CPT1B(5), CPT1C(6), CPT2(2), G6PC(1), G6PC2(2), IKBKB(3), IRS1(15), IRS2(3), IRS4(17), JAK1(8), JAK2(4), JAK3(5), LEP(4), LEPR(13), MAPK10(5), MAPK8(3), MAPK9(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NPY(1), PCK2(3), POMC(1), PPARA(1), PPARGC1A(12), PRKAA1(4), PRKAB1(3), PRKAG2(4), PRKAG3(4), PRKCQ(4), RXRA(1), RXRG(11), STAT3(8), TNFRSF1B(1), TRAF2(1), TYK2(2)	27527861	238	122	238	96	38	72	52	42	34	0	0.99	1.00	1.00
213	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(4), CDC40(2), CLK2(6), CLK3(1), CLK4(6), COL2A1(7), CPSF1(7), CPSF2(5), CPSF3(3), CPSF4(2), CSTF1(1), CSTF2T(4), CSTF3(3), DDIT3(4), DDX1(5), DDX20(1), DHX15(4), DHX16(5), DHX38(8), DHX8(8), DHX9(5), DICER1(8), DNAJC8(2), FUS(1), GIPC1(2), LOC440563(7), METTL3(1), NCBP2(1), NONO(2), NUDT21(1), NXF1(8), PABPN1(1), PAPOLA(6), POLR2A(9), PPM1G(4), PRPF18(2), PRPF3(3), PRPF4(3), PRPF4B(6), PRPF8(6), PSKH1(2), PTBP1(2), PTBP2(8), RBM17(3), RBM5(3), RNGTT(4), RNMT(3), SF3A1(5), SF3A3(1), SF3B1(5), SF3B2(8), SF3B4(6), SF3B5(2), SF4(6), SFRS14(6), SFRS16(1), SFRS4(4), SFRS5(1), SFRS6(4), SFRS8(5), SNRPA(1), SNRPA1(1), SNRPB2(1), SNRPD1(1), SNRPD3(2), SNRPE(1), SNRPG(1), SNRPN(4), SNURF(1), SPOP(1), SRPK1(3), SRPK2(4), SRRM1(1), SUPT5H(5), TXNL4A(3), U2AF2(5), XRN2(5)	36276119	283	120	279	78	61	62	75	48	37	0	0.34	1.00	1.00
214	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(1), IMPA2(1), INPP1(3), INPP4A(5), INPP4B(14), INPP5A(3), INPP5B(2), INPPL1(8), IPMK(7), ISYNA1(2), ITGB1BP3(2), ITPK1(1), ITPKA(1), ITPKB(5), OCRL(6), PI4KA(7), PI4KB(4), PIK3C3(7), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIP4K2A(5), PIP4K2B(2), PIP4K2C(3), PIP5K1A(5), PIP5K1B(7), PIP5K1C(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCD3(2), PLCD4(3), PLCE1(14), PLCG1(5), PLCG2(9), PLCZ1(3), PTEN(8), PTPMT1(1), SYNJ1(4), SYNJ2(3)	25659221	232	119	227	76	29	69	63	33	38	0	0.79	1.00	1.00
215	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(5), AGTR2(2), ATP8A1(3), AVPR1A(6), AVPR1B(3), AVPR2(4), BDKRB1(1), BDKRB2(1), BRS3(8), C3AR1(5), CCKAR(7), CCKBR(11), CCR1(2), CCR2(5), CCR3(2), CCR4(2), CCR5(1), CCR6(2), CCR8(6), CX3CR1(5), CXCR3(1), CXCR4(3), CXCR6(1), EDNRB(6), FPR1(4), FSHR(20), GALR1(3), GALR2(1), GALT(2), GHSR(4), GNB2L1(2), GNRHR(2), GPR77(1), GRPR(5), LHCGR(6), MC2R(2), MC3R(9), MC4R(1), MC5R(10), NMBR(6), NPY1R(9), NPY2R(6), NPY5R(9), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(5), OPRL1(5), OPRM1(4), OXTR(2), PPYR1(2), SSTR1(3), SSTR3(2), SSTR4(5), TAC4(1), TACR1(3), TACR3(8), TRHR(4), TSHR(10)	17948562	255	117	254	98	24	85	73	46	26	1	0.89	1.00	1.00
216	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	59	AKT2(2), AKT3(5), BCL10(1), BLNK(1), BTK(11), CARD11(17), CD19(2), CD22(6), CD72(1), CD79B(1), CHUK(3), CR2(8), FCGR2B(2), FOS(1), GSK3B(2), HRAS(1), IKBKB(3), INPP5D(4), LILRB3(1), LYN(4), MALT1(6), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PLCG2(9), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PTPN6(3), RAC2(1), RASGRP3(8), SYK(3), VAV1(1), VAV2(3), VAV3(14)	24978633	221	116	218	79	25	56	70	35	35	0	0.87	1.00	1.00
217	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	78	AIFM1(9), AKT2(2), AKT3(5), APAF1(8), ATM(22), BAX(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CAPN2(3), CASP10(6), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(3), CSF2RB(5), DFFA(3), DFFB(2), FADD(1), FAS(3), FASLG(4), IKBKB(3), IL1A(3), IL1R1(1), IL1RAP(2), IL3(1), IL3RA(5), IRAK1(3), IRAK2(3), IRAK3(6), IRAK4(4), MAP3K14(1), MYD88(3), NFKB1(3), NFKB2(6), NFKBIA(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RIPK1(4), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(1), TRAF2(1)	27808844	215	114	211	77	24	49	69	39	34	0	0.93	1.00	1.00
218	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT2(2), AKT3(5), CDC42(2), CDK2(4), CDKN1B(3), CREB5(7), EBP(2), ERBB4(21), F2RL2(5), GAB1(2), GADD45A(1), GRB2(4), GSK3B(2), IGF1(5), IGFBP1(3), INPPL1(8), IRS1(15), IRS2(3), IRS4(17), MET(12), NOLC1(2), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PARD3(6), PDK1(4), PIK3CA(11), PIK3CD(1), PPP1R13B(2), PREX1(21), PTEN(8), PTK2(11), PTPN1(1), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KB1(2), SHC1(2), SOS1(12), SOS2(6), TSC1(9), TSC2(4), YWHAG(2)	26448584	271	114	265	80	45	84	68	35	39	0	0.46	1.00	1.00
219	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(2), ACTR3(1), AKT2(2), AKT3(5), ANGPTL2(4), ARHGAP1(3), ARHGAP4(2), ARHGEF11(11), BTK(11), CDC42(2), CFL2(2), GDI1(3), GDI2(1), INPPL1(8), ITPR1(11), ITPR2(25), ITPR3(6), MYLK(16), MYLK2(3), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PDK1(4), PIK3CA(11), PIK3CD(1), PIK3CG(11), PIK3R1(3), PITX2(4), PPP1R13B(2), PTEN(8), RACGAP1(3), RHO(1), ROCK1(10), ROCK2(4), SAG(3), WASF1(8), WASL(5)	24267588	231	112	224	64	38	68	54	30	41	0	0.37	1.00	1.00
220	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	66	AKT2(2), AKT3(5), CASP9(3), CDC42(2), HRAS(1), KDR(30), MAP2K1(6), MAP2K2(1), MAPK11(1), MAPK14(1), MAPK3(1), MAPKAPK2(3), MAPKAPK3(1), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NOS3(2), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCG1(5), PLCG2(9), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKCA(7), PRKCG(10), PTGS2(4), PTK2(11), PXN(1), RAC2(1), RAF1(3), SH2D2A(7), SHC2(1), SPHK2(2), SRC(2), VEGFA(1)	24218811	237	111	233	79	37	66	65	43	26	0	0.70	1.00	1.00
221	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	25	CPEB1(5), ERBB2(10), ERBB4(21), ETS1(7), ETS2(3), ETV6(4), FMN2(33), GRB2(4), MAP2K1(6), MAPK3(1), NOTCH1(8), NOTCH2(28), NOTCH3(6), NOTCH4(23), PIWIL1(11), PIWIL2(6), PIWIL3(6), PIWIL4(4), RAF1(3), SOS1(12), SOS2(6), SPIRE1(5), SPIRE2(1)	16446093	213	109	209	55	27	71	57	33	24	1	0.31	1.00	1.00
222	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(4), ACSS2(4), ACYP2(1), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH7A1(1), ALDH9A1(3), ALDOA(2), ALDOB(4), ALDOC(1), BPGM(2), DLAT(5), DLD(6), ENO1(3), ENO3(2), FBP2(1), G6PC(1), G6PC2(2), GALM(1), GAPDH(3), GAPDHS(6), GCK(4), GPI(3), HK1(3), HK2(9), HK3(12), LDHA(3), LDHAL6A(3), LDHB(2), LDHC(5), PDHA1(3), PDHA2(13), PFKL(2), PFKM(5), PFKP(3), PGAM1(1), PGAM2(1), PGAM4(2), PGK1(5), PGK2(14), PGM1(2), PGM3(4), PKLR(11), PKM2(4), TPI1(6)	20068415	239	108	236	76	35	93	53	34	24	0	0.62	1.00	1.00
223	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), AGK(2), AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CEL(4), DAK(1), DGAT1(2), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKI(23), DGKZ(3), GK(2), GK2(4), GLA(4), GPAM(3), LCT(30), LIPA(2), LIPC(6), LIPF(3), LIPG(2), LPL(5), MGLL(1), PNLIP(8), PNLIPRP1(7), PNLIPRP2(7), PNPLA3(2), PPAP2B(2), PPAP2C(1)	20368176	244	108	244	65	24	84	72	30	33	1	0.22	1.00	1.00
224	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(16), COL4A2(16), COL4A3(5), COL4A4(13), COL4A5(23), COL4A6(17), F10(3), F11(8), F12(1), F2(5), F2R(4), F5(23), F8(23), F9(8), FGA(9), FGB(13), FGG(2), KLKB1(3), PROC(3), PROS1(13), SERPINC1(8), SERPING1(3)	15473530	219	108	218	78	18	86	48	35	32	0	0.99	1.00	1.00
225	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT2(2), AKT3(5), BTK(11), FCER1A(7), FCER1G(2), FYN(3), GAB2(1), GRB2(4), HRAS(1), IL13(1), IL3(1), IL4(1), INPP5D(4), LAT(3), LCP2(6), LYN(4), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(6), MS4A2(2), PDK1(4), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCG1(5), PLCG2(9), PRKCA(7), PRKCD(1), PRKCE(3), RAC2(1), RAF1(3), SOS1(12), SOS2(6), SYK(3), VAV1(1), VAV2(3), VAV3(14)	24639255	237	107	233	80	30	65	69	41	32	0	0.81	1.00	1.00
226	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(5), CHUK(3), DAXX(6), ELK1(2), FOS(1), GRB2(4), HRAS(1), IKBKB(3), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K1(4), MAP3K10(1), MAP3K11(7), MAP3K12(5), MAP3K13(7), MAP3K14(1), MAP3K2(5), MAP3K3(4), MAP3K4(14), MAP3K5(12), MAP3K6(1), MAP3K7(5), MAP3K8(2), MAP3K9(11), MAP4K1(5), MAP4K3(5), MAP4K5(1), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK4(6), MAPK6(1), MAPK7(5), MAPK8(3), MAPK9(6), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(3), MAX(3), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), MKNK1(2), MKNK2(1), NFKB1(3), NFKBIA(1), PAK1(5), PAK2(3), RAF1(3), RIPK1(4), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA4(1), RPS6KA5(4), RPS6KB1(2), RPS6KB2(2), SHC1(2), SP1(1), STAT1(4), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TRAF2(1)	32474032	240	107	240	79	49	50	68	35	38	0	0.64	1.00	1.00
227	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	ALG2(5), BAX(1), BFAR(1), BTK(11), CAD(16), CASP10(6), CASP3(4), CASP8(4), CASP8AP2(10), CDK2AP1(1), CSNK1A1(1), DAXX(6), DEDD(2), DFFA(3), EPHB2(7), FADD(1), FAF1(4), FAIM2(4), HSPB1(1), IL1A(3), MAP2K4(3), MAP2K7(2), MAP3K1(4), MAP3K5(12), MAPK10(5), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), MET(12), NFAT5(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NR0B2(1), PFN1(1), PFN2(3), PTPN13(11), RALBP1(1), RIPK1(4), ROCK1(10), SMPD1(2), TPX2(3), TRAF2(1), TUFM(2)	24137058	202	107	202	62	27	51	67	24	33	0	0.60	1.00	1.00
228	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	CAD(16), CANT1(3), CTPS(5), CTPS2(5), DCK(2), DCTD(5), DHODH(1), DPYD(12), DPYS(10), DTYMK(2), ENTPD1(4), ENTPD4(2), ENTPD6(3), ITPA(1), NME6(1), NME7(4), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5E(2), NT5M(1), NUDT2(3), PNPT1(5), POLA1(6), POLA2(2), POLD1(2), POLD2(2), POLD3(3), POLE(19), POLE2(1), POLR1A(8), POLR1B(10), POLR1D(2), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLR3A(12), POLR3B(15), POLR3G(1), POLR3H(1), PRIM1(3), RFC5(1), RRM1(5), RRM2(4), TK2(1), TXNRD1(1), TXNRD2(1), UCK2(2), UMPS(2), UPP1(6), UPP2(8), UPRT(4)	27738541	243	106	240	83	45	67	73	33	24	1	0.76	1.00	1.00
229	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(4), AGT(2), CALM1(2), CALR(1), CAMK1(2), CAMK4(8), CREBBP(4), CSNK1A1(1), EDN1(1), ELSPBP1(4), F2(5), GATA4(4), GSK3B(2), HAND1(3), HAND2(3), HRAS(1), IGF1(5), LIF(2), MAP2K1(6), MAPK14(1), MAPK3(1), MAPK8(3), MEF2C(2), MYH2(37), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NKX2-5(3), NPPA(1), PIK3CA(11), PIK3R1(3), PPP3CB(1), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RAF1(3), RPS6KB1(2), SYT1(3)	17072866	174	106	171	51	24	54	56	20	20	0	0.36	1.00	1.00
230	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(5), ADCY4(6), ADCY6(10), ADCY8(22), CACNA1A(10), CACNA1B(15), GNAS(7), GNAT3(1), GNB1(2), GNB3(2), GNG3(2), GRM4(9), ITPR3(6), KCNB1(16), PDE1A(8), PLCB2(6), PRKACB(3), PRKACG(1), PRKX(3), SCNN1A(1), SCNN1B(3), SCNN1G(3), TAS1R1(3), TAS1R2(7), TAS1R3(3), TAS2R1(7), TAS2R10(1), TAS2R13(1), TAS2R14(3), TAS2R16(10), TAS2R3(2), TAS2R38(5), TAS2R39(5), TAS2R40(4), TAS2R41(3), TAS2R42(1), TAS2R46(2), TAS2R5(1), TAS2R50(4), TAS2R60(7), TAS2R9(1), TRPM5(1)	19798653	212	105	211	64	20	83	55	30	24	0	0.36	1.00	1.00
231	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(13), AMY2A(4), AMY2B(16), ENPP1(6), ENPP3(12), G6PC(1), GAA(2), GANAB(3), GBE1(2), GCK(4), GPI(3), GUSB(4), GYS1(2), GYS2(3), HK1(3), HK2(9), HK3(12), MGAM(30), PGM1(2), PGM3(4), PYGB(1), PYGL(3), PYGM(6), SI(63), UCHL1(1), UGDH(4), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2B15(6), UGT2B4(13), UXS1(4)	19517212	266	105	264	82	41	94	67	38	26	0	0.70	1.00	1.00
232	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AADAT(1), ABP1(10), ACAT1(1), ACAT2(1), ACMSD(2), AFMID(2), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(4), AOC3(5), AOX1(14), ASMT(6), CAT(3), CYP1A1(6), CYP1A2(2), CYP1B1(2), DDC(6), EHHADH(8), GCDH(3), HADH(4), HADHA(3), HSD17B4(5), INMT(5), KMO(4), KYNU(5), LCMT1(2), LCMT2(4), LNX1(4), MAOA(3), MAOB(1), METTL2B(5), METTL6(1), NFX1(2), OGDH(1), OGDHL(11), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), TDO2(7), TPH1(11), TPH2(8), WARS(3), WARS2(9), WBSCR22(1)	20514049	219	104	214	74	21	59	68	33	37	1	0.82	1.00	1.00
233	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ABP1(10), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), AOC2(4), AOC3(5), AOX1(14), DBH(2), DCT(7), DDC(6), ESCO1(7), ESCO2(2), FAH(1), GOT1(2), GOT2(4), GSTZ1(1), HGD(4), HPD(2), LCMT1(2), LCMT2(4), MAOA(3), MAOB(1), METTL2B(5), METTL6(1), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), SH3GLB1(1), TAT(4), TH(2), TPO(16), TYR(14), TYRP1(4), WBSCR22(1)	20154061	225	103	225	67	33	84	50	26	32	0	0.54	1.00	1.00
234	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ACTG1(2), ARHGEF2(6), ARPC5(1), CD14(1), CDC42(2), CDH1(5), CLDN1(3), CTNNB1(11), CTTN(3), EZR(1), FYN(3), HCLS1(6), ITGB1(3), KRT18(1), LY96(1), NCK1(3), NCK2(3), NCL(4), OCLN(1), PRKCA(7), RHOA(1), ROCK1(10), ROCK2(4), TLR4(31), TLR5(1), TUBA1A(3), TUBA1B(1), TUBA1C(3), TUBA3C(12), TUBA3D(9), TUBA3E(2), TUBA4A(3), TUBA8(1), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB4(5), TUBB4Q(12), TUBB8(7), WAS(3), WASL(5)	18035811	191	103	188	71	33	61	50	26	21	0	0.94	1.00	1.00
235	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ACTG1(2), ARHGEF2(6), ARPC5(1), CD14(1), CDC42(2), CDH1(5), CLDN1(3), CTNNB1(11), CTTN(3), EZR(1), FYN(3), HCLS1(6), ITGB1(3), KRT18(1), LY96(1), NCK1(3), NCK2(3), NCL(4), OCLN(1), PRKCA(7), RHOA(1), ROCK1(10), ROCK2(4), TLR4(31), TLR5(1), TUBA1A(3), TUBA1B(1), TUBA1C(3), TUBA3C(12), TUBA3D(9), TUBA3E(2), TUBA4A(3), TUBA8(1), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB4(5), TUBB4Q(12), TUBB8(7), WAS(3), WASL(5)	18035811	191	103	188	71	33	61	50	26	21	0	0.94	1.00	1.00
236	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	67	ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), AKR1C1(2), AKR1C2(2), AKR1C3(2), AKR1C4(1), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), CYP1A1(6), CYP1A2(2), CYP1B1(2), CYP2B6(8), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2F1(2), CYP2S1(1), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(4), DHDH(1), EPHX1(2), GSTA1(1), GSTA2(3), GSTA3(2), GSTA4(1), GSTA5(3), GSTK1(4), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(1), MGST1(1), MGST3(3), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8)	19023488	228	102	225	77	23	92	57	31	25	0	0.88	1.00	1.00
237	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACADM(3), ACOX1(3), ACOX2(2), ACOX3(6), ACSL1(8), ACSL3(3), ACSL4(2), ACSL5(1), ACSL6(7), ADIPOQ(4), ANGPTL4(1), APOA1(1), APOA5(3), APOC3(3), CD36(4), CPT1A(7), CPT1B(5), CPT1C(6), CPT2(2), CYP27A1(5), CYP4A11(4), CYP7A1(7), CYP8B1(2), EHHADH(8), FABP1(1), FABP2(1), FABP3(2), FABP5(1), FABP6(1), FADS2(1), GK(2), GK2(4), HMGCS2(6), ILK(1), LPL(5), ME1(1), MMP1(7), NR1H3(4), OLR1(3), PCK2(3), PDPK1(1), PLTP(2), PPARA(1), PPARD(2), PPARG(3), RXRA(1), RXRG(11), SCP2(3), SLC27A1(3), SLC27A2(3), SLC27A4(3), SLC27A5(1), SLC27A6(11), SORBS1(7), UBC(10), UCP1(2)	22126438	204	102	202	61	32	69	43	37	23	0	0.48	1.00	1.00
238	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT2(2), AKT3(5), BCL2(1), BCR(3), BLNK(1), BTK(11), CD19(2), CD22(6), CR2(8), DAG1(2), FLOT1(2), FLOT2(1), GRB2(4), GSK3B(2), INPP5D(4), ITPR1(11), ITPR2(25), ITPR3(6), LYN(4), MAP4K1(5), MAPK3(1), NFATC1(3), NFATC2(8), NR0B2(1), PDK1(4), PIK3CA(11), PIK3CD(1), PIK3R1(3), PLCG2(9), PPP1R13B(2), PPP3CB(1), PPP3CC(2), PTPRC(21), RAF1(3), SHC1(2), SOS1(12), SOS2(6), SYK(3), VAV1(1)	25181756	199	102	195	62	23	57	53	33	33	0	0.57	1.00	1.00
239	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(2), ACTG2(5), ACTR2(2), ACTR3(1), ANGPTL2(4), CDC42(2), CFL2(2), FLNA(11), FLNC(18), FSCN1(3), FSCN3(7), GDI1(3), GDI2(1), MYH2(37), MYLK(16), MYLK2(3), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PFN1(1), PFN2(3), RHO(1), ROCK1(10), ROCK2(4), VASP(3), WASF1(8), WASL(5)	16505633	187	101	186	58	27	67	41	23	29	0	0.67	1.00	1.00
240	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	52	AKR1C4(1), AKR1D1(5), ARSD(3), CYP11B1(10), CYP11B2(7), CYP19A1(3), HSD11B1(4), HSD11B2(1), HSD17B12(1), HSD17B2(3), HSD17B3(1), HSD17B7(1), HSD3B1(7), HSD3B2(13), LCMT1(2), LCMT2(4), METTL2B(5), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), SRD5A1(3), SRD5A2(3), STS(5), SULT1E1(1), SULT2A1(3), SULT2B1(1), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8), WBSCR22(1)	16319456	197	100	195	63	20	77	57	29	14	0	0.73	1.00	1.00
241	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	62	ATM(22), CCNA1(2), CCNB1(1), CCND1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(1), CDC25A(4), CDK2(4), CDK4(2), CDK7(3), CDKN1A(1), CDKN1B(3), CDKN2D(1), CREB3L1(1), CREB3L3(1), CREB3L4(1), E2F1(3), E2F3(1), E2F6(3), GADD45A(1), GBA2(2), MCM2(6), MCM3(5), MCM4(6), MCM5(3), MCM6(10), MCM7(4), MDM2(2), MNAT1(2), MYT1(6), NACA(1), ORC1L(4), ORC2L(4), ORC3L(1), ORC4L(1), ORC5L(5), ORC6L(1), PCNA(1), POLA2(2), POLE(19), POLE2(1), PRIM1(3), RB1(13), RBL1(7), RPA2(1), TFDP1(3), TFDP2(2), TNXB(15), WEE1(3)	26159357	195	99	193	55	37	42	57	25	34	0	0.33	1.00	1.00
242	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(10), ACAT1(1), ACAT2(1), ACMSD(2), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), AOC2(4), AOC3(5), AOX1(14), ASMT(6), CAT(3), CYP19A1(3), CYP1A1(6), CYP1A2(2), CYP2A13(4), CYP2A6(4), CYP2A7(4), CYP2B6(8), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2F1(2), CYP2J2(8), CYP3A4(1), CYP3A5(1), CYP3A7(4), CYP4B1(8), CYP4F8(5), CYP51A1(3), DDC(6), EHHADH(8), GCDH(3), HADHA(3), KMO(4), KYNU(5), MAOA(3), MAOB(1), SDS(2), TDO2(7), TPH1(11), WARS(3), WARS2(9)	19017305	227	99	223	74	29	70	56	31	39	2	0.72	1.00	1.00
243	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(23), AXIN1(3), CCND1(2), CCND2(1), CCND3(1), CSNK1E(6), CTNNB1(11), DVL1(1), DVL2(1), DVL3(5), FBXW2(2), FOSL1(3), FZD1(3), FZD10(8), FZD2(3), FZD3(4), FZD5(1), FZD7(3), FZD9(2), GSK3B(2), LDLR(4), MAPK10(5), MAPK9(6), PLAU(1), PPP2R5C(1), PPP2R5E(4), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCI(7), PRKCQ(4), PRKCZ(2), PRKD1(16), RHOA(1), SFRP4(3), TCF7(1), WNT1(3), WNT10A(4), WNT10B(2), WNT11(2), WNT16(2), WNT2(4), WNT2B(2), WNT4(1), WNT5A(1), WNT5B(3), WNT6(1), WNT7A(6), WNT7B(2)	20636335	196	99	194	52	36	55	57	23	25	0	0.15	1.00	1.00
244	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(1), BMP4(4), BMP5(4), BMP6(3), BMP7(4), BMP8A(1), BTRC(9), CSNK1A1(1), CSNK1A1L(5), CSNK1D(2), CSNK1E(6), CSNK1G1(1), CSNK1G2(1), CSNK1G3(3), DHH(1), GAS1(1), GLI1(13), GLI2(10), GLI3(17), GSK3B(2), HHIP(1), IHH(1), LRP2(45), PRKACB(3), PRKACG(1), PRKX(3), PTCH1(8), PTCH2(2), SHH(4), SMO(5), STK36(5), WNT1(3), WNT10A(4), WNT10B(2), WNT11(2), WNT16(2), WNT2(4), WNT2B(2), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(3), WNT6(1), WNT7A(6), WNT7B(2), WNT8A(3), WNT8B(2), WNT9A(2), WNT9B(5), ZIC2(6)	21042352	222	98	218	63	47	63	62	30	19	1	0.30	1.00	1.00
245	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(3), INPP4A(5), INPP4B(14), INPP5A(3), INPPL1(8), ITPKA(1), ITPKB(5), OCRL(6), PIK3C2A(10), PIK3C2B(7), PIK3C2G(9), PIK3CA(11), PIK3CB(7), PIK3CG(11), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCG1(5), PLCG2(9)	15515895	161	98	157	48	21	43	48	20	29	0	0.56	1.00	1.00
246	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	APC(23), ASAH1(2), CAMP(2), CAV3(2), DAG1(2), DLG4(3), EPHB2(7), GNAI1(3), GNAQ(2), ITPR1(11), ITPR2(25), ITPR3(6), KCNJ3(15), KCNJ5(1), PITX2(4), PTX3(2), RHO(1), RYR1(52)	15931301	163	98	161	41	18	44	48	25	28	0	0.17	1.00	1.00
247	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH9A1(3), ALDOA(2), ALDOB(4), ALDOC(1), BPGM(2), DLAT(5), DLD(6), ENO1(3), ENO3(2), FBP2(1), G6PC(1), GAPDH(3), GCK(4), GPI(3), HK1(3), HK2(9), HK3(12), LDHA(3), LDHB(2), LDHC(5), PDHA1(3), PDHA2(13), PFKM(5), PFKP(3), PGAM1(1), PGK1(5), PGM1(2), PGM3(4), PKLR(11), PKM2(4), TPI1(6)	16820508	206	97	203	60	32	81	46	26	21	0	0.37	1.00	1.00
248	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH9A1(3), ALDOA(2), ALDOB(4), ALDOC(1), BPGM(2), DLAT(5), DLD(6), ENO1(3), ENO3(2), FBP2(1), G6PC(1), GAPDH(3), GCK(4), GPI(3), HK1(3), HK2(9), HK3(12), LDHA(3), LDHB(2), LDHC(5), PDHA1(3), PDHA2(13), PFKM(5), PFKP(3), PGAM1(1), PGK1(5), PGM1(2), PGM3(4), PKLR(11), PKM2(4), TPI1(6)	16820508	206	97	203	60	32	81	46	26	21	0	0.37	1.00	1.00
249	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	32	AKT2(2), AKT3(5), ASAH1(2), DAG1(2), DRD2(9), EPHB2(7), GRB2(4), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), KCNJ3(15), KCNJ5(1), PI3(1), PIK3CB(7), PITX2(4), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), RAF1(3), RGS20(5), SHC1(2), SOS1(12), SOS2(6), SRC(2), STAT3(8)	18813266	189	97	187	55	25	56	54	29	25	0	0.45	1.00	1.00
250	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH6(8), ADH7(4), ADHFE1(2), AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AKR1B1(2), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), CEL(4), DGAT1(2), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKZ(3), GK(2), GLA(4), LCT(30), LIPC(6), LIPF(3), LIPG(2), LPL(5), PNLIP(8), PNLIPRP1(7), PNLIPRP2(7), PPAP2B(2), PPAP2C(1)	16758907	211	96	211	55	20	75	60	26	30	0	0.21	1.00	1.00
251	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(2), APAF1(8), BAG4(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP2(7), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(3), DAXX(6), DFFA(3), DFFB(2), FADD(1), GSN(3), LMNB1(2), LMNB2(2), MAP2K7(2), MAP3K1(4), MAP3K14(1), MAP3K5(12), MAPK8(3), MDM2(2), NFKB1(3), NFKBIA(1), NUMA1(6), PAK2(3), PRKCD(1), PRKDC(23), PSEN1(1), PSEN2(4), PTK2(11), RASA1(3), RB1(13), RIPK1(4), SPTAN1(12), TNFRSF1B(1), TRAF2(1)	24100647	172	96	172	58	28	41	42	22	39	0	0.92	1.00	1.00
252	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(8), ATM(22), ATR(17), BAI1(10), BAX(1), BID(1), CASP3(4), CASP8(4), CASP9(3), CCNB1(1), CCNB2(1), CCNB3(13), CCND1(2), CCND2(1), CCND3(1), CCNE1(3), CCNG1(2), CD82(2), CDK2(4), CDK4(2), CDK6(3), CDKN1A(1), CHEK1(6), CHEK2(2), EI24(1), FAS(3), GADD45A(1), GTSE1(3), IGF1(5), IGFBP3(2), LRDD(1), MDM2(2), PPM1D(6), PTEN(8), RCHY1(1), RFWD2(3), RRM2(4), SERPINB5(6), SERPINE1(5), SESN2(2), THBS1(4), TNFRSF10B(1), TP53I3(2), TP73(4), TSC2(4), ZMAT3(1)	22092088	183	96	181	54	25	48	50	33	27	0	0.56	1.00	1.00
253	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT2(2), AKT3(5), BCR(3), BTK(11), CD19(2), DAPP1(2), FLOT1(2), FLOT2(1), GAB1(2), ITPR1(11), ITPR2(25), ITPR3(6), LYN(4), NR0B2(1), PDK1(4), PIK3CA(11), PITX2(4), PLCG2(9), PPP1R13B(2), PREX1(21), PTEN(8), PTPRC(21), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KB1(2), SAG(3), SYK(3), TEC(5), VAV1(1)	19018908	180	96	175	46	22	52	50	28	28	0	0.20	1.00	1.00
254	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(5), ALPL(2), ALPP(4), ALPPL2(3), ASCC3(10), ATP13A2(5), DDX18(3), DDX19A(1), DDX23(8), DDX4(6), DDX41(1), DDX47(1), DDX50(6), DDX52(3), DDX54(2), DDX55(1), DDX56(1), DHX58(1), ENTPD7(3), EP400(14), ERCC2(3), ERCC3(5), FPGS(1), GCH1(4), GGH(4), IFIH1(6), MOV10L1(9), NUDT5(2), NUDT8(1), QDPR(4), RAD54B(8), RAD54L(1), RUVBL2(3), SETX(17), SKIV2L2(10), SMARCA2(10), SMARCA5(1)	21726604	169	95	169	59	23	40	52	30	23	1	0.81	1.00	1.00
255	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(7), CREBBP(4), DLL1(5), DLL3(3), DLL4(1), DTX1(4), DTX2(2), DTX3(4), DTX3L(2), DTX4(1), DVL1(1), DVL2(1), DVL3(5), EP300(2), HDAC1(3), HDAC2(8), HES1(1), JAG1(4), JAG2(2), LFNG(1), MAML1(5), MAML2(3), MAML3(7), NCOR2(13), NCSTN(4), NOTCH1(8), NOTCH2(28), NOTCH3(6), NOTCH4(23), NUMB(2), NUMBL(1), PSEN1(1), PSEN2(4), PSENEN(1), PTCRA(2), RBPJ(3), RBPJL(2), SNW1(2)	24025077	176	95	176	60	28	51	51	17	28	1	0.78	1.00	1.00
256	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(9), CD28(1), CD3D(2), CTLA4(1), DAG1(2), DTYMK(2), EPHB2(7), FBXW7(4), GRAP2(5), GRB2(4), ITK(7), ITPKA(1), ITPKB(5), LAT(3), LCK(5), LCP2(6), NCK1(3), NFAT5(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PAK1(5), PAK2(3), PAK3(7), PAK4(1), PAK7(19), PLCG1(5), PTPRC(21), RAF1(3), RASGRP1(2), RASGRP2(1), RASGRP3(8), RASGRP4(2), SOS1(12), SOS2(6), VAV1(1), ZAP70(4)	19339966	184	94	184	53	27	60	45	24	28	0	0.45	1.00	1.00
257	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(56), CDR1(4), DGKI(23), PIGK(2), RPL10(2), RPL11(1), RPL12(1), RPL14(1), RPL15(1), RPL19(2), RPL21(1), RPL22(1), RPL24(1), RPL27A(1), RPL29(1), RPL3(1), RPL30(3), RPL35(1), RPL37(1), RPL3L(2), RPL4(5), RPL5(1), RPL6(3), RPL7(1), RPL7A(1), RPL8(1), RPLP0(3), RPLP2(1), RPS10(1), RPS11(1), RPS12(1), RPS13(2), RPS15(1), RPS18(1), RPS26(1), RPS29(1), RPS4Y1(1), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5), RPS6KB1(2), RPS6KB2(2), RPSA(1), SLC36A2(3), UBC(10)	18271223	164	93	163	50	26	55	42	21	19	1	0.63	1.00	1.00
258	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(3), AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(1), CDIPT(1), CDS1(2), CDS2(3), CHAT(8), CHKA(1), CHKB(2), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKI(23), DGKZ(3), ESCO1(7), ESCO2(2), ETNK1(1), ETNK2(1), GNPAT(3), GPAM(3), GPD1(2), GPD1L(6), GPD2(4), LCAT(1), LYPLA1(1), LYPLA2(1), MYST3(8), MYST4(8), NAT6(1), PCYT1A(2), PCYT1B(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLD1(9), PLD2(5), PNPLA3(2), PPAP2B(2), PPAP2C(1), PTDSS1(5), PTDSS2(2), SH3GLB1(1)	22733746	206	92	206	61	28	57	61	31	28	1	0.51	1.00	1.00
259	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(16), CANT1(3), CTPS(5), CTPS2(5), DCK(2), DCTD(5), DHODH(1), DPYD(12), DPYS(10), DTYMK(2), ENTPD1(4), ITPA(1), NT5E(2), NT5M(1), NUDT2(3), POLB(2), POLD1(2), POLD2(2), POLE(19), POLG(11), POLL(2), POLQ(17), POLR1B(10), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLRMT(1), RRM1(5), RRM2(4), TK2(1), TXNRD1(1), UCK2(2), UMPS(2), UNG(5), UPP1(6)	19805523	192	92	190	57	41	42	59	27	22	1	0.34	1.00	1.00
260	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	19	F10(3), F11(8), F12(1), F13B(16), F2(5), F5(23), F7(2), F8(23), F9(8), FGA(9), FGB(13), FGG(2), PLAT(6), PLAU(1), PLG(13), SERPINB2(6), SERPINE1(5), VWF(13)	11139705	157	90	156	40	14	51	40	28	23	1	0.43	1.00	1.00
261	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT2(2), AKT3(5), CAB39(2), DDIT4(2), EIF4B(5), FIGF(1), HIF1A(1), IGF1(5), MAPK3(1), PDPK1(1), PGF(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(7), PRKAA1(4), RHEB(4), RICTOR(19), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5), RPS6KB1(2), RPS6KB2(2), TSC1(9), TSC2(4), ULK1(3), ULK2(2), ULK3(1), VEGFA(1), VEGFC(11)	17774522	145	89	141	47	18	38	48	24	17	0	0.61	1.00	1.00
262	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(3), APOA1(1), CD36(4), CITED2(2), CPT1B(5), CREBBP(4), EHHADH(8), EP300(2), FABP1(1), HSD17B4(5), LPL(5), MAPK3(1), ME1(1), NCOA1(5), NCOR1(10), NCOR2(13), NFKBIA(1), NR0B2(1), NR1H3(4), NR2F1(1), NRIP1(8), PDGFA(6), PIK3CA(11), PIK3R1(3), PPARA(1), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PTGS2(4), RB1(13), RXRA(1), SP1(1), SRA1(2), STAT5A(3), STAT5B(4)	21741260	153	89	147	51	24	38	41	19	31	0	0.80	1.00	1.00
263	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(10), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH4A1(3), ALDH9A1(3), AMD1(1), AOC2(4), AOC3(5), ARG1(1), ASL(3), CKM(1), CKMT1A(2), CKMT1B(1), CKMT2(2), CPS1(39), DAO(1), GATM(4), GLUD1(3), GOT1(2), GOT2(4), MAOA(3), MAOB(1), NOS1(9), NOS3(2), OAT(1), ODC1(1), OTC(5), P4HA1(3), P4HA2(2), P4HA3(2), P4HB(4), RARS(5), SMS(1)	15277277	156	88	155	56	22	42	46	26	20	0	0.88	1.00	1.00
264	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(4), ACADM(3), ACAT1(1), ACAT2(1), ACOX1(3), ACOX3(6), ACSL1(8), ACSL3(3), ACSL4(2), ACSL5(1), ACSL6(7), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CPT1A(7), CPT1B(5), CPT1C(6), CPT2(2), CYP4A11(4), DCI(2), EHHADH(8), GCDH(3), HADH(4), HADHA(3), HADHB(4), HSD17B4(5)	16841805	159	88	156	46	18	62	28	26	24	1	0.50	1.00	1.00
265	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	63	ADAM10(6), ADAM17(7), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(4), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), CASP3(4), CDC42(2), CHUK(3), CXCL1(2), F11R(2), HBEGF(1), IGSF5(3), IKBKB(3), JAM2(6), LYN(4), MAP2K4(3), MAP3K14(1), MAPK10(5), MAPK11(1), MAPK14(1), MAPK8(3), MAPK9(6), MET(12), NFKB1(3), NFKB2(6), NFKBIA(1), NOD1(3), PAK1(5), PLCG1(5), PLCG2(9), PTPRZ1(36), SRC(2), TCIRG1(1), TJP1(10)	22780462	195	88	194	74	35	47	53	26	34	0	0.96	1.00	1.00
266	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	46	AADAT(1), AASDHPPT(2), AASS(7), ACAT1(1), ACAT2(1), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), BBOX1(3), DLST(2), DOT1L(8), EHHADH(8), EHMT1(8), EHMT2(1), GCDH(3), HADH(4), HADHA(3), HSD17B4(5), HSD3B7(2), NSD1(11), OGDH(1), OGDHL(11), PLOD1(2), PLOD2(6), PLOD3(4), RDH11(2), SETD1A(8), SETD7(1), SETDB1(5), SHMT1(2), SHMT2(2), SPCS1(1), SPCS3(1), SUV39H1(2), SUV39H2(3), TMLHE(2)	19810103	144	87	141	53	20	35	46	22	19	2	0.87	1.00	1.00
267	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	42	ALDOA(2), ALDOB(4), ALDOC(1), DLAT(5), DLD(6), ENO1(3), ENO3(2), FBP2(1), G6PC(1), GAPDH(3), GAPDHS(6), GCK(4), GOT1(2), GOT2(4), GPI(3), HK1(3), HK2(9), HK3(12), LDHA(3), LDHB(2), LDHC(5), MDH1(2), MDH2(2), PC(1), PDHA1(3), PDHA2(13), PDHX(4), PFKL(2), PFKM(5), PFKP(3), PGAM1(1), PGAM2(1), PGK1(5), PGK2(14), PKLR(11), PKM2(4), TPI1(6)	14189527	158	86	155	53	29	53	37	24	15	0	0.59	1.00	1.00
268	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CALR(1), CANX(2), CD4(3), CD8A(2), CD8B(3), CIITA(4), CTSB(1), CTSS(1), HLA-A(2), HLA-B(3), HLA-C(3), HLA-DMA(2), HLA-DMB(1), HLA-DOA(2), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(3), HLA-G(1), HSP90AA1(5), HSP90AB1(3), HSPA5(4), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(4), IFNA8(1), KIR2DL1(4), KIR2DL3(2), KIR2DL4(1), KIR2DS4(4), KIR3DL1(10), KLRC1(3), KLRC2(3), KLRC3(3), KLRD1(2), LGMN(4), LTA(2), NFYB(1), NFYC(2), PDIA3(2), PSME1(1), PSME2(1), RFX5(6), TAP2(7), TAPBP(2)	16155034	142	86	140	59	20	30	45	29	18	0	0.97	1.00	1.00
269	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	32	APC(23), AR(5), ASAH1(2), CAMP(2), CCL13(2), CCL15(3), DAG1(2), GNA11(1), GNAI1(3), GNAQ(2), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), KCNJ3(15), KCNJ5(1), MAPK10(5), MAPK14(1), PHKA2(10), PIK3CA(11), PIK3CD(1), PIK3R1(3), PITX2(4), PTX3(2), RAF1(3), SRC(2)	17066683	151	86	146	40	19	41	41	21	29	0	0.35	1.00	1.00
270	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(4), ADRA1B(4), ADRA1D(2), ADRA2A(1), ADRA2C(3), ADRB2(2), ADRB3(3), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), DRD1(3), DRD2(9), DRD3(9), DRD5(9), HRH1(6), HRH2(6), HTR1A(13), HTR1B(5), HTR1D(1), HTR1E(9), HTR1F(4), HTR2A(3), HTR2B(2), HTR2C(6), HTR5A(11), HTR6(5), HTR7(3)	8817874	160	85	159	69	16	63	48	23	10	0	0.87	1.00	1.00
271	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	ATF2(5), CDC42(2), DLD(6), DUSP10(6), DUSP8(1), GAB1(2), GADD45A(1), GCK(4), IL1R1(1), MAP2K4(3), MAP2K7(2), MAP3K1(4), MAP3K10(1), MAP3K11(7), MAP3K12(5), MAP3K13(7), MAP3K2(5), MAP3K3(4), MAP3K4(14), MAP3K5(12), MAP3K7(5), MAP3K9(11), MAPK10(5), MAPK7(5), MAPK8(3), MAPK9(6), MYEF2(4), NFATC3(10), NR2C2(2), PAPPA(12), SHC1(2), TRAF6(4), ZAK(3)	16997983	164	85	163	46	40	37	47	25	15	0	0.32	1.00	1.00
272	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(4), ADC(2), ALDH4A1(3), ALDH5A1(2), CAD(16), CPS1(39), EARS2(2), EPRS(13), GAD1(5), GAD2(10), GCLC(8), GCLM(1), GFPT1(4), GFPT2(6), GLS(3), GLS2(2), GLUD1(3), GLUD2(5), GLUL(2), GMPS(8), GOT1(2), GOT2(4), GPT2(3), GSR(1), GSS(3), NADSYN1(1), NAGK(1), PPAT(5), QARS(2)	13623439	160	84	159	45	21	47	40	31	20	1	0.49	1.00	1.00
273	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT2(2), AKT3(5), BCR(3), BLNK(1), BTK(11), CD19(2), DAG1(2), EPHB2(7), GRB2(4), ITPKA(1), ITPKB(5), LYN(4), MAP2K1(6), MAP2K2(1), NFAT5(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PI3(1), PIK3CA(11), PIK3CD(1), PIK3R1(3), PLCG2(9), PPP1R13B(2), RAF1(3), SERPINA4(9), SHC1(2), SOS1(12), SOS2(6), SYK(3), VAV1(1)	18092603	134	84	131	40	14	29	41	30	20	0	0.44	1.00	1.00
274	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CALM1(2), CD3D(2), ELK1(2), FOS(1), FYN(3), GRB2(4), HRAS(1), LAT(3), LCK(5), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB1(3), NFKBIA(1), PIK3CA(11), PIK3R1(3), PLCG1(5), PPP3CB(1), PPP3CC(2), PRKCA(7), RAF1(3), RASA1(3), SHC1(2), SOS1(12), SYT1(3), VAV1(1), ZAP70(4)	16032977	130	84	126	40	23	30	44	16	17	0	0.47	1.00	1.00
275	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(10), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), AOC2(4), AOC3(5), AOX1(14), DBH(2), DCT(7), DDC(6), FAH(1), GOT1(2), GOT2(4), GSTZ1(1), HGD(4), HPD(2), MAOA(3), MAOB(1), TAT(4), TH(2), TPO(16), TYR(14)	10944826	152	83	152	46	19	64	27	19	23	0	0.57	1.00	1.00
276	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12(3), ALOX12B(1), ALOX15(4), ALOX15B(2), ALOX5(6), CYP2B6(8), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2J2(8), CYP2U1(2), CYP4A11(4), CYP4F2(5), CYP4F3(12), DHRS4(1), EPHX2(1), GGT1(1), GPX1(1), GPX3(1), GPX5(4), GPX6(3), GPX7(3), LTA4H(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PTGDS(2), PTGIS(5), PTGS1(5), PTGS2(4), TBXAS1(6)	13383676	145	82	144	47	23	42	41	21	17	1	0.58	1.00	1.00
277	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(11), CALM1(2), ELK1(2), FCER1A(7), FCER1G(2), FOS(1), GRB2(4), HRAS(1), LYN(4), MAP2K1(6), MAP2K4(3), MAP2K7(2), MAP3K1(4), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), PAK2(3), PIK3CA(11), PIK3R1(3), PLA2G4A(10), PLCG1(5), PPP3CB(1), PPP3CC(2), RAF1(3), SHC1(2), SOS1(12), SYK(3), SYT1(3), VAV1(1)	14402268	141	81	138	36	21	36	43	21	20	0	0.19	1.00	1.00
278	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ABP1(10), ACY3(2), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH7A1(1), ALDH9A1(3), AMDHD1(3), AOC2(4), AOC3(5), ASPA(2), CNDP1(5), DDC(6), FTCD(3), HAL(2), HARS(2), HARS2(3), HDC(7), HNMT(2), LCMT1(2), LCMT2(4), MAOA(3), MAOB(1), METTL2B(5), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), PRPS1(3), PRPS2(2), UROC1(9), WBSCR22(1)	13327800	135	81	135	39	24	34	45	18	14	0	0.23	1.00	1.00
279	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(3), B4GALT5(3), C1GALT1(2), C1GALT1C1(2), GALNT1(3), GALNT10(3), GALNT11(2), GALNT12(4), GALNT13(15), GALNT14(10), GALNT2(4), GALNT3(4), GALNT4(4), GALNT5(6), GALNT6(2), GALNT7(5), GALNT8(6), GALNT9(1), GALNTL1(4), GALNTL2(6), GALNTL4(6), GALNTL5(5), GCNT1(4), GCNT3(3), GCNT4(3), OGT(6), ST3GAL1(3), ST3GAL2(3), ST6GALNAC1(3), WBSCR17(16)	11092302	141	81	140	52	30	35	32	28	16	0	0.94	1.00	1.00
280	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT2(2), AKT3(5), BRD4(6), CBL(9), CDC42(2), F2RL2(5), FLOT1(2), FLOT2(1), GRB2(4), GSK3B(2), IGFBP1(3), INPPL1(8), IRS1(15), IRS2(3), IRS4(17), LNPEP(1), MAPK3(1), PARD3(6), PDK1(4), PIK3CA(11), PIK3CD(1), PIK3R1(3), PPYR1(2), PTEN(8), PTPN1(1), RAF1(3), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KB1(2), SERPINB6(2), SHC1(2), SORBS1(7), SOS1(12), SOS2(6), YWHAG(2)	20221158	167	81	162	59	32	36	56	23	20	0	0.77	1.00	1.00
281	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(2), EIF1(1), EIF2B1(1), EIF2B2(2), EIF2B3(3), EIF2B4(3), EIF2B5(3), EIF2S3(2), ELAVL1(3), FLT1(21), FLT4(13), HIF1A(1), HRAS(1), KDR(30), NOS3(2), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), PTK2(11), PXN(1), SHC1(2), VHL(1)	11744952	129	81	125	31	18	41	39	16	15	0	0.15	1.00	1.00
282	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(10), AGXT(3), AGXT2(8), ALAS1(3), AMT(2), AOC2(4), AOC3(5), BHMT(6), CBS(1), CHKA(1), CHKB(2), CPT1B(5), CTH(1), DAO(1), DLD(6), DMGDH(4), GARS(4), GATM(4), GCAT(4), GLDC(11), MAOA(3), MAOB(1), PLCB2(6), PLCG1(5), PLCG2(9), PSPH(5), SARDH(5), SARS(2), SHMT1(2), SHMT2(2), TARS(5)	14591193	130	80	130	37	23	39	35	23	10	0	0.35	1.00	1.00
283	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	19	ADCYAP1R1(6), CALCR(8), CALCRL(10), CD97(4), CRHR1(1), CRHR2(2), EMR1(10), EMR2(3), GHRHR(5), GIPR(2), GLP1R(1), GLP2R(9), GPR64(7), LPHN1(3), LPHN2(24), LPHN3(32), SCTR(1), VIPR2(4)	8788104	132	80	132	50	9	48	31	29	15	0	0.94	1.00	1.00
284	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	33	ACTA1(4), CRKL(2), DOCK1(7), ELK1(2), FOS(1), GAB1(2), GRB2(4), HRAS(1), ITGA1(9), ITGB1(3), MAP2K1(6), MAP2K2(1), MAP4K1(5), MAPK3(1), MAPK8(3), MET(12), PAK1(5), PIK3CA(11), PIK3R1(3), PTEN(8), PTK2(11), PTK2B(8), PXN(1), RAF1(3), RAP1A(2), RAP1B(1), RASA1(3), SOS1(12), SRC(2), STAT3(8)	14240594	141	80	137	41	22	28	31	35	25	0	0.54	1.00	1.00
285	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(4), APC(23), ATF2(5), AXIN1(3), BMP10(6), BMP2(1), BMP4(4), BMP5(4), BMP7(4), BMPR1A(1), BMPR2(2), CHRD(9), CTNNB1(11), DVL1(1), FZD1(3), GATA4(4), GSK3B(2), MAP3K7(5), MEF2C(2), MYL2(2), NKX2-5(3), NPPA(1), RFC1(6), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), TGFBR3(13), WNT1(3)	12563856	137	79	135	41	18	42	34	22	21	0	0.67	1.00	1.00
286	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(4), ACAA2(4), ACADM(3), ACAT1(1), ACAT2(1), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOX1(14), AUH(1), BCAT1(1), BCAT2(1), BCKDHB(5), DBT(10), DLD(6), EHHADH(8), HADH(4), HADHA(3), HADHB(4), HIBADH(1), HIBCH(4), HMGCS1(5), HMGCS2(6), HSD17B4(5), IVD(3), MCCC1(2), MCCC2(3), MCEE(1), MUT(6), OXCT1(4), PCCA(5), PCCB(2)	14806911	138	79	136	43	9	44	35	19	28	3	0.73	1.00	1.00
287	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	33	AKT2(2), AKT3(5), ARHGEF11(11), BCL2(1), CDC42(2), DLG4(3), GNA13(5), MAP2K4(3), MAP3K1(4), MAP3K5(12), MAPK8(3), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PDK1(4), PHKA2(10), PI3(1), PIK3CB(7), PLD1(9), PLD2(5), PLD3(1), PTK2(11), RDX(2), ROCK1(10), ROCK2(4), SERPINA4(9)	15913210	135	79	135	36	22	36	36	18	23	0	0.35	1.00	1.00
288	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(3), ELK1(2), FOS(1), IKBKB(3), IRAK1(3), LY96(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAP3K7(5), MAPK14(1), MAPK8(3), MYD88(3), NFKB1(3), NFKBIA(1), PPARA(1), TLR10(6), TLR2(2), TLR4(31), TLR6(6), TLR7(8), TLR9(6), TOLLIP(1), TRAF6(4)	12531338	110	79	109	42	12	32	25	17	24	0	0.95	1.00	1.00
289	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(10), ACACB(11), ACAT1(1), ACAT2(1), ACOT12(4), ACSS1(4), ACSS2(4), ACYP2(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), DLAT(5), DLD(6), GLO1(1), GRHPR(1), HAGH(1), HAGHL(1), LDHA(3), LDHAL6A(3), LDHB(2), LDHC(5), LDHD(2), MDH1(2), MDH2(2), ME1(1), ME2(7), ME3(2), PC(1), PCK2(3), PDHA1(3), PDHA2(13), PKLR(11), PKM2(4)	15661768	138	78	137	48	24	41	37	20	16	0	0.79	1.00	1.00
290	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT2(2), AKT3(5), ANKRD6(1), APC(23), AXIN1(3), AXIN2(2), CER1(2), CSNK1A1(1), CTNNB1(11), DACT1(12), DKK1(2), DKK2(4), DKK4(2), DVL1(1), FSTL1(3), GSK3B(2), LRP1(21), MVP(3), NKD1(6), NKD2(3), PSEN1(1), PTPRA(4), SENP2(3), SFRP1(1), TSHB(1)	13926635	119	78	117	33	11	36	38	13	21	0	0.50	1.00	1.00
291	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	ELK1(2), FOS(1), GRB2(4), HRAS(1), JAK1(8), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), PDGFA(6), PDGFRA(17), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), RAF1(3), RASA1(3), SHC1(2), SOS1(12), STAT1(4), STAT3(8), STAT5A(3)	11969601	117	77	114	34	16	23	37	25	16	0	0.51	1.00	1.00
292	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(3), AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPS(3), CDIPT(1), CDS1(2), CDS2(3), CHAT(8), CHKA(1), CHKB(2), CLC(1), CPT1B(5), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKZ(3), ETNK1(1), GNPAT(3), GPD1(2), GPD2(4), LCAT(1), LGALS13(2), LYPLA1(1), LYPLA2(1), PAFAH2(1), PCYT1A(2), PCYT1B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCB2(6), PLCG1(5), PLCG2(9), PPAP2B(2), PPAP2C(1)	17365757	147	76	147	44	18	35	46	28	20	0	0.50	1.00	1.00
293	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(14), GABBR1(3), GPRC5A(1), GPRC5B(7), GPRC5C(1), GRM1(26), GRM2(5), GRM3(9), GRM4(9), GRM5(13), GRM7(15), GRM8(19)	7178692	122	76	122	41	11	37	44	21	9	0	0.52	1.00	1.00
294	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	ABP1(10), AGXT(3), AGXT2(8), ALAS1(3), AMT(2), AOC2(4), AOC3(5), BHMT(6), CBS(1), CHKA(1), CHKB(2), CTH(1), DAO(1), DLD(6), DMGDH(4), GARS(4), GATM(4), GCAT(4), GLDC(11), HSD3B7(2), MAOA(3), MAOB(1), PHGDH(3), PSAT1(2), PSPH(5), RDH11(2), SARDH(5), SARS(2), SDS(2), SHMT1(2), SHMT2(2), TARS(5), TARS2(9)	14655771	125	76	124	41	20	41	32	19	13	0	0.63	1.00	1.00
295	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	40	ALAD(2), ALAS1(3), BLVRA(1), BLVRB(1), COX15(2), CP(7), CPOX(4), EARS2(2), EPRS(13), FECH(2), FTMT(4), GUSB(4), HMBS(3), HMOX1(3), PPOX(3), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8)	13908544	139	76	137	43	13	55	35	23	13	0	0.71	1.00	1.00
296	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(1), CHUK(3), DAXX(6), EGF(9), ETS1(7), ETS2(3), FOS(1), HOXA7(3), HRAS(1), IKBKB(3), MAP2K1(6), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K1(4), MAP3K14(1), MAP3K5(12), MAPK14(1), MAPK3(1), MAPK8(3), NFKB1(3), NFKBIA(1), PPP2CA(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCQ(4), RAF1(3), RIPK1(4), SP1(1), TNFRSF1B(1), TRAF2(1)	15960384	119	76	119	47	17	31	32	19	20	0	0.94	1.00	1.00
297	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(8), BAX(1), BCL2(1), BCL2L11(2), BID(1), BIRC2(2), BIRC3(3), BIRC5(1), CASP1(2), CASP10(6), CASP2(7), CASP3(4), CASP4(3), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CHUK(3), DFFA(3), DFFB(2), FADD(1), FAS(3), FASLG(4), GZMB(3), HELLS(1), IKBKB(3), IRF1(1), IRF2(1), IRF3(1), IRF4(3), IRF6(5), IRF7(1), LTA(2), MAP2K4(3), MAP3K1(4), MAPK10(5), MDM2(2), NFKB1(3), NFKBIA(1), NFKBIE(1), PLEKHG5(5), PRF1(5), RIPK1(4), TNFRSF10B(1), TNFRSF1B(1), TNFRSF21(2), TNFRSF25(1), TNFSF10(1), TP73(4), TRAF2(1), TRAF3(3)	19619575	134	75	134	43	15	37	33	21	28	0	0.77	1.00	1.00
298	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(4), ALDH4A1(3), ALDH5A1(2), CAD(16), CPS1(39), EPRS(13), GAD1(5), GAD2(10), GCLC(8), GCLM(1), GFPT1(4), GLS(3), GLS2(2), GLUD1(3), GLUL(2), GMPS(8), GOT1(2), GOT2(4), GPT2(3), GSS(3), NADSYN1(1), PPAT(5), QARS(2)	11439237	143	75	142	41	19	41	39	26	17	1	0.53	1.00	1.00
299	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(5), ADRBK2(4), ARRB2(2), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CLCA1(5), CLCA2(11), CLCA4(12), CNGA3(9), CNGA4(7), CNGB1(4), GUCA1A(1), GUCA1B(1), GUCA1C(4), PDC(1), PDE1C(17), PRKACB(3), PRKACG(1), PRKG1(3), PRKG2(7), PRKX(3)	10497589	113	75	113	37	19	43	18	14	19	0	0.77	1.00	1.00
300	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	20	CALM1(2), DLG4(3), GRIN1(2), GRIN2A(26), GRIN2B(22), GRIN2C(3), GRIN2D(6), NOS1(9), PPP3CB(1), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), SYT1(3)	8453535	98	75	98	43	15	28	32	11	12	0	0.96	1.00	1.00
301	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	BAG4(1), CASP2(7), CASP3(4), CASP8(4), DFFA(3), DFFB(2), FADD(1), LMNB1(2), LMNB2(2), MADD(13), MAP2K4(3), MAP3K1(4), MAP3K7(5), MAPK8(3), PAK1(5), PAK2(3), PRKDC(23), RB1(13), RIPK1(4), SPTAN1(12), TRAF2(1)	13602600	115	75	115	29	26	24	25	16	24	0	0.30	1.00	1.00
302	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(7), ATP4A(7), ATP4B(1), ATP5A1(3), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP5G3(2), ATP5L(2), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(4), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), COX15(2), COX4I1(1), COX5B(1), COX6B1(1), COX6B2(1), COX7B2(1), COX8A(1), COX8C(1), CYC1(2), LHPP(2), NDUFA10(2), NDUFA11(1), NDUFA12(2), NDUFA13(4), NDUFA4(1), NDUFA8(3), NDUFA9(5), NDUFB11(1), NDUFB2(4), NDUFB4(1), NDUFB5(4), NDUFB6(1), NDUFB9(1), NDUFC2(1), NDUFS1(7), NDUFS2(6), NDUFS3(1), NDUFS4(1), NDUFS6(1), NDUFS8(1), NDUFV1(3), PPA1(1), SDHA(5), SDHB(1), SDHD(1), TCIRG1(1), UQCRB(4), UQCRC2(4), UQCRFS1(2), UQCRQ(1)	19192261	150	74	149	72	28	31	44	24	23	0	1.00	1.00	1.00
303	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	44	AACS(6), AADAC(3), ABAT(4), ACAT1(1), ACAT2(1), ACSM1(6), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH5A1(2), ALDH7A1(1), ALDH9A1(3), BDH2(1), DDHD1(3), EHHADH(8), GAD1(5), GAD2(10), HADH(4), HADHA(3), HMGCS1(5), HMGCS2(6), HSD17B4(5), HSD3B7(2), ILVBL(1), L2HGDH(2), OXCT1(4), PDHA1(3), PDHA2(13), PLA1A(4), PPME1(3), PRDX6(3), RDH11(2)	13722138	131	74	129	42	16	40	31	20	21	3	0.70	1.00	1.00
304	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(21), AR(5), ESR1(1), ESR2(3), HNF4A(5), NPM1(2), NR0B1(5), NR1D1(3), NR1D2(2), NR1H2(3), NR1H3(4), NR1I2(2), NR1I3(5), NR2C2(2), NR2E1(7), NR2F1(1), NR2F2(2), NR3C1(3), NR4A1(2), NR4A2(7), NR5A1(2), NR5A2(5), PGR(6), PPARA(1), PPARD(2), PPARG(3), RARA(3), RARB(3), RARG(1), ROR1(4), RORA(5), RORC(2), RXRA(1), RXRG(11), THRA(1), THRB(5), VDR(1)	14429519	141	74	141	69	30	45	33	20	13	0	1.00	1.00	1.00
305	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(22), BMPR1B(5), CCND2(1), CDK4(2), CDKN1B(3), DAZL(2), DMC1(1), EGR1(2), ESR2(3), FSHR(20), GJA4(1), LHCGR(6), MLH1(5), MSH5(4), NCOR1(10), NR5A1(2), NRIP1(8), PGR(6), PRLR(9), PTGER2(2), SMPD1(2), VDR(1), ZP2(2)	12067613	119	74	118	38	13	32	40	18	16	0	0.73	1.00	1.00
306	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(22), ATR(17), BRCA1(9), BRCA2(16), CHEK1(6), CHEK2(2), FANCA(5), FANCC(1), FANCD2(9), FANCE(3), FANCF(2), FANCG(4), HUS1(2), MRE11A(6), RAD1(5), RAD17(2), RAD50(3), RAD51(1), RAD9A(2), TREX1(1)	14899885	118	73	112	26	7	33	33	20	25	0	0.48	1.00	1.00
307	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	37	ACAA2(4), ACAD8(3), ACAD9(3), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), AKR1C4(1), AKR1D1(5), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), BAAT(5), CEL(4), CYP27A1(5), CYP7A1(7), HADHB(4), HSD3B7(2), LIPA(2), RDH11(2), SLC27A5(1), SOAT1(7), SRD5A1(3), SRD5A2(3)	10705292	128	73	127	42	9	52	29	20	17	1	0.72	1.00	1.00
308	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(4), CARS(1), CARS2(1), DARS2(3), EARS2(2), EPRS(13), FARS2(1), FARSA(2), FARSB(3), GARS(4), HARS(2), HARS2(3), IARS(9), IARS2(7), KARS(4), LARS(7), LARS2(2), MARS(2), MARS2(8), MTFMT(1), NARS(3), NARS2(3), PARS2(1), QARS(2), RARS(5), RARS2(2), SARS(2), TARS(5), TARS2(9), VARS(6), VARS2(8), WARS(3), WARS2(9), YARS(1), YARS2(2)	18699453	141	73	140	39	21	44	39	22	15	0	0.36	1.00	1.00
309	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(5), CDC42(2), DAXX(6), DDIT3(4), ELK1(2), GRB2(4), HRAS(1), HSPB1(1), HSPB2(1), MAP2K4(3), MAP2K6(1), MAP3K1(4), MAP3K5(12), MAP3K7(5), MAP3K9(11), MAPK14(1), MAPKAPK2(3), MAPKAPK5(3), MAX(3), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), MKNK1(2), PLA2G4A(10), RIPK1(4), RPS6KA5(4), SHC1(2), STAT1(4), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TRAF2(1)	12674463	118	73	118	32	17	28	31	25	17	0	0.41	1.00	1.00
310	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(2), AGTR2(2), CALM1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CDK5(1), F2(5), FYN(3), GNA11(1), GNAI1(3), GNB1(2), GNGT1(2), GRB2(4), HRAS(1), JAK2(4), MAP2K1(6), MAP2K2(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPT(8), MYLK(16), PLCG1(5), PRKCA(7), PTK2B(8), RAF1(3), SHC1(2), SOS1(12), STAT1(4), STAT3(8), STAT5A(3), SYT1(3)	14373185	131	72	129	46	23	36	29	23	20	0	0.82	1.00	1.00
311	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM1(2), CAMK1(2), ELK1(2), FPR1(4), GNB1(2), GNGT1(2), HRAS(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K6(1), MAP3K1(4), MAPK14(1), MAPK3(1), NCF1(1), NCF2(2), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB1(3), NFKBIA(1), PAK1(5), PIK3C2G(9), PLCB1(18), PPP3CB(1), PPP3CC(2), RAF1(3), SYT1(3)	12877586	112	72	112	35	21	34	31	7	19	0	0.51	1.00	1.00
312	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(2), ATM(22), ATR(17), CCNA1(2), CCND1(2), CCNE1(3), CDC25A(4), CDK2(4), CDK4(2), CDK6(3), CDKN1A(1), CDKN1B(3), E2F1(3), GSK3B(2), HDAC1(3), RB1(13), SKP2(4), TFDP1(3), TGFB1(2), TGFB2(8), TGFB3(1)	9955088	104	72	103	25	10	32	24	16	22	0	0.42	1.00	1.00
313	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(1), B4GALT2(2), FBP2(1), G6PC(1), GAA(2), GALE(1), GALK2(2), GALT(2), GANAB(3), GCK(4), GLA(4), HK1(3), HK2(9), HK3(12), LCT(30), MGAM(30), PFKM(5), PFKP(3), PGM1(2), PGM3(4)	11299547	123	72	122	36	25	34	37	19	8	0	0.27	1.00	1.00
314	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	31	AKR1B1(2), B4GALT1(1), B4GALT2(2), G6PC(1), G6PC2(2), GAA(2), GALE(1), GALK2(2), GALT(2), GANC(1), GCK(4), GLA(4), HK1(3), HK2(9), HK3(12), HSD3B7(2), LCT(30), MGAM(30), PFKL(2), PFKM(5), PFKP(3), PGM1(2), PGM3(4), RDH11(2), UGP2(1)	13202537	129	72	128	39	25	36	40	20	8	0	0.33	1.00	1.00
315	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(4), ACTN1(2), ACTN2(23), ACTN3(3), BCAR1(2), BCR(3), CAPNS2(2), CRKL(2), FYN(3), GRB2(4), HRAS(1), ITGA1(9), ITGB1(3), MAP2K1(6), MAP2K2(1), MAPK3(1), MAPK8(3), PPP1R12B(5), PTK2(11), PXN(1), RAF1(3), RAP1A(2), ROCK1(10), SHC1(2), SOS1(12), SRC(2), TLN1(13), VCL(2), ZYX(2)	16248466	137	72	135	53	28	38	21	34	16	0	0.92	1.00	1.00
316	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(2), ACTR3(1), ANGPTL2(4), DAG1(2), DGKA(5), GCA(1), ITGA9(2), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), MAP2K1(6), MAPK3(1), NR1I3(5), PAK1(5), PDE3A(13), PDE3B(9), PI3(1), PIK3C2G(9), PIK3CA(11), PIK3CD(1), PIK3R1(3), PSME1(1), RIPK3(4), SGCB(1), VASP(3)	16948061	138	72	134	30	24	35	35	21	23	0	0.061	1.00	1.00
317	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(1), BTK(11), CALM1(2), CD79B(1), ELK1(2), FOS(1), GRB2(4), HRAS(1), LYN(4), MAP2K1(6), MAP3K1(4), MAPK14(1), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), PLCG1(5), PPP3CB(1), PPP3CC(2), PRKCA(7), RAF1(3), SHC1(2), SOS1(12), SYK(3), SYT1(3), VAV1(1)	12753697	110	71	110	33	20	27	34	16	13	0	0.37	1.00	1.00
318	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(3), CDK2(4), CDT1(2), DIAPH2(6), GMNN(1), MCM10(2), MCM2(6), MCM3(5), MCM4(6), MCM5(3), MCM6(10), MCM7(4), NACA(1), ORC1L(4), ORC2L(4), ORC3L(1), ORC4L(1), ORC5L(5), ORC6L(1), PCNA(1), POLA2(2), POLD1(2), POLD2(2), POLD3(3), POLE(19), POLE2(1), PRIM1(3), RFC1(6), RFC2(2), RFC3(1), RFC4(1), RFC5(1), RPA2(1), RPA4(5), UBC(10)	17523538	130	71	129	33	34	28	41	13	14	0	0.13	1.00	1.00
319	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	ELK1(2), GNAS(7), GNB1(2), GNGT1(2), GRB2(4), HRAS(1), IGF1R(10), ITGB1(3), KLK2(4), MAP2K1(6), MAP2K2(1), MAPK3(1), MKNK1(2), MKNK2(1), NGFR(2), PDGFRA(17), PPP2CA(1), PTPRR(8), RAF1(3), RPS6KA1(1), RPS6KA5(4), SHC1(2), SOS1(12), SRC(2), STAT3(8)	10458201	106	71	106	39	10	31	31	23	11	0	0.92	1.00	1.00
320	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(10), ADC(2), ALDH18A1(1), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AMD1(1), AOC2(4), AOC3(5), ARG1(1), ASL(3), ASS1(3), CPS1(39), GATM(4), MAOA(3), MAOB(1), ODC1(1), OTC(5), SAT1(1), SMS(1), SRM(2)	10196683	108	71	107	37	12	29	29	21	17	0	0.81	1.00	1.00
321	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ARG1(1), ASL(3), ASS1(3), CKM(1), CKMT1A(2), CKMT1B(1), CKMT2(2), CPS1(39), DAO(1), EPRS(13), GATM(4), GLUD1(3), GLUD2(5), GOT1(2), GOT2(4), LAP3(1), NOS1(9), NOS3(2), OAT(1), OTC(5), P4HA1(3), P4HA2(2), P4HA3(2), PARS2(1), PYCR2(1), RARS(5), RARS2(2)	12373786	121	71	120	45	15	36	36	20	14	0	0.94	1.00	1.00
322	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10(9), ALG10B(6), ALG12(2), ALG13(9), ALG14(2), ALG2(5), ALG3(5), ALG8(2), ALG9(3), B4GALT1(1), B4GALT2(2), B4GALT3(1), DAD1(1), DDOST(1), DHDDS(1), DOLPP1(3), DPAGT1(1), DPM1(1), FUT8(4), GANAB(3), MAN1A2(9), MAN1B1(3), MAN1C1(2), MAN2A1(11), MGAT1(2), MGAT3(4), MGAT4A(3), MGAT4B(1), MGAT5(6), MGAT5B(7), RFT1(4), RPN2(4), STT3B(2)	14680503	120	71	120	40	17	38	35	17	13	0	0.79	1.00	1.00
323	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	ABO(2), B3GALNT1(1), B3GALT1(2), B3GALT2(2), B3GALT5(1), B3GNT1(3), B3GNT2(1), B3GNT3(1), B3GNT5(1), B4GALNT1(4), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), B4GALT6(3), FUT1(2), FUT3(2), FUT7(2), FUT9(7), GCNT2(2), PIGB(1), PIGC(2), PIGG(7), PIGK(2), PIGL(2), PIGM(5), PIGN(2), PIGO(7), PIGP(1), PIGQ(1), PIGS(1), PIGT(2), PIGV(3), PIGX(4), PIGZ(1), ST3GAL1(3), ST3GAL2(3), ST3GAL3(1), ST3GAL4(2), ST3GAL6(3), ST6GALNAC3(8), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(4)	16714939	113	71	111	48	26	21	37	20	9	0	0.94	1.00	1.00
324	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(8), AASDHPPT(2), AASS(7), ACAT1(1), ACAT2(1), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), BBOX1(3), DLST(2), DOT1L(8), EHHADH(8), EHMT1(8), EHMT2(1), GCDH(3), HADHA(3), PLOD1(2), PLOD2(6), PLOD3(4), SDS(2), SHMT1(2), SHMT2(2), TMLHE(2)	12828351	107	71	105	31	15	29	33	14	14	2	0.46	1.00	1.00
325	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT2(2), AKT3(5), GRB2(4), IARS(9), IL2RG(3), IL4(1), IL4R(5), INPP5D(4), JAK1(8), JAK2(4), JAK3(5), NR0B2(1), PI3(1), PIK3CA(11), PPP1R13B(2), RPS6KB1(2), SERPINA4(9), SHC1(2), SOS1(12), SOS2(6), SRC(2), STAT6(2), TYK2(2)	12721179	102	71	99	33	8	27	35	21	11	0	0.70	1.00	1.00
326	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(5), ARSB(1), ARSD(3), CYP11B1(10), CYP11B2(7), HSD11B1(4), HSD11B2(1), HSD17B2(3), HSD17B3(1), HSD3B1(7), HSD3B2(13), SRD5A1(3), SRD5A2(3), STS(5), SULT1E1(1), SULT2A1(3), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2B15(6), UGT2B4(13)	9448311	120	70	119	40	10	49	30	21	10	0	0.76	1.00	1.00
327	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(6), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CFLAR(1), DAXX(6), DFFA(3), DFFB(2), FADD(1), FAF1(4), LMNB1(2), LMNB2(2), MAP2K4(3), MAP3K1(4), MAP3K7(5), MAPK8(3), PAK1(5), PAK2(3), PRKDC(23), PTPN13(11), RB1(13), SPTAN1(12)	14378223	119	70	119	42	24	26	29	13	27	0	0.92	1.00	1.00
328	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(22), ATR(17), BRCA1(9), CCNB1(1), CDC25A(4), CDC25B(1), CDC25C(3), CDC34(1), CDKN1A(1), CDKN2D(1), CHEK1(6), CHEK2(2), EP300(2), GADD45A(1), MDM2(2), MYT1(6), PRKDC(23), RPS6KA1(1), WEE1(3)	14339293	106	70	105	21	8	30	30	17	21	0	0.23	1.00	1.00
329	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(10), CALM1(2), ELK1(2), FOS(1), GNAI1(3), GNAQ(2), GNAS(7), GNB1(2), GNGT1(2), HRAS(1), MAP2K1(6), MAPK3(1), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), PLCG1(5), PPP3CB(1), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), RAF1(3), RPS6KA3(1), SYT1(3)	11625414	102	70	102	31	18	27	32	11	14	0	0.43	1.00	1.00
330	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(10), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), AOC2(4), AOC3(5), DDC(6), EPX(7), ESCO1(7), ESCO2(2), GOT1(2), GOT2(4), HPD(2), LPO(4), MAOA(3), MAOB(1), MPO(4), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), PRDX6(3), SH3GLB1(1), TAT(4), TPO(16)	11768310	112	70	112	39	16	35	28	19	14	0	0.80	1.00	1.00
331	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), ARSB(1), FUCA1(1), FUCA2(1), GBA(3), GUSB(4), HEXA(1), HGSNAT(4), HPSE(1), HPSE2(6), HYAL1(1), HYAL2(1), IDS(3), IDUA(2), LCT(30), MAN2B1(2), MAN2B2(3), MAN2C1(4), MANBA(4), NAGLU(1), NEU1(1), NEU3(3), NEU4(6), SPAM1(12)	11948533	96	70	96	35	10	34	31	12	9	0	0.81	1.00	1.00
332	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(10), ARHGEF1(2), F2(5), F2R(4), F2RL3(2), GNA12(1), GNA13(5), GNAI1(3), GNAQ(2), GNB1(2), GNGT1(2), MAP3K7(5), PIK3CA(11), PIK3R1(3), PLCB1(18), PPP1R12B(5), PRKCA(7), PTK2B(8), ROCK1(10)	8952755	105	70	102	26	16	32	29	10	18	0	0.25	1.00	1.00
333	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(8), BAX(1), BCL2(1), CASP1(2), CASP10(6), CASP2(7), CASP3(4), CASP4(3), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CD40LG(6), DAXX(6), DFFA(3), DFFB(2), FADD(1), FAS(3), FASLG(4), IKBKE(5), LTA(2), MCL1(1), NFKB1(3), NFKBIA(1), NGFR(2), NR3C1(3), PTPN13(11), RIPK1(4), SFRS2IP(12), TFG(1), TNFRSF1B(1), TRAF2(1), TRAF3(3), TRAF6(4)	14687373	120	69	119	42	13	38	29	22	18	0	0.90	1.00	1.00
334	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(3), ALOX15(4), ALOX5(6), CYP4F2(5), CYP4F3(12), EPX(7), GGT1(1), LPO(4), LTA4H(1), MPO(4), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PRDX1(2), PRDX2(1), PRDX5(1), PRDX6(3), PTGDS(2), PTGIS(5), PTGS1(5), PTGS2(4), TBXAS1(6), TPO(16)	9543117	115	69	115	34	13	28	33	25	16	0	0.48	1.00	1.00
335	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(10), ACAT1(1), ACAT2(1), ACYP2(1), ADH5(4), AKR1B1(2), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), DLAT(5), DLD(6), GLO1(1), GRHPR(1), HAGH(1), HAGHL(1), LDHA(3), LDHB(2), LDHC(5), LDHD(2), MDH1(2), MDH2(2), ME1(1), ME2(7), ME3(2), PC(1), PDHA1(3), PDHA2(13), PKLR(11), PKM2(4)	12311269	123	69	122	30	20	37	35	15	16	0	0.17	1.00	1.00
336	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(3), CDK5(1), CHN1(4), MAP3K1(4), MYL2(2), MYLK(16), NCF2(2), PAK1(5), PDGFRA(17), PIK3CA(11), PIK3R1(3), PLD1(9), PPP1R12B(5), RALBP1(1), RPS6KB1(2), TRIO(15), VAV1(1), WASF1(8)	12037385	109	69	104	29	13	29	36	14	17	0	0.33	1.00	1.00
337	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	32	A1BG(2), AKT2(2), AKT3(5), BTK(11), DAPP1(2), GRB2(4), GSK3B(2), IARS(9), IGFBP1(3), INPP5D(4), PDK1(4), PIK3CA(11), PPP1R13B(2), PTEN(8), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KB1(2), SHC1(2), SOS1(12), SOS2(6), TEC(5), YWHAG(2)	12241653	107	69	103	36	9	24	40	20	14	0	0.82	1.00	1.00
338	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(2), ACP2(1), ACP5(3), ACPP(7), ALPI(5), ALPL(2), ALPP(4), ALPPL2(3), CYP19A1(3), CYP1A1(6), CYP1A2(2), CYP2A13(4), CYP2A6(4), CYP2A7(4), CYP2B6(8), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2F1(2), CYP2J2(8), CYP3A4(1), CYP3A5(1), CYP3A7(4), CYP4B1(8), CYP4F8(5), CYP51A1(3), PON1(3)	10113327	115	68	114	42	17	30	30	17	20	1	0.76	1.00	1.00
339	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	39	AKR1B1(2), ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), FPGT(2), FUK(3), GMDS(6), GMPPA(5), GMPPB(1), HK1(3), HK2(9), HK3(12), HSD3B7(2), KHK(2), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(6), PFKFB1(6), PFKFB2(3), PFKFB3(5), PFKFB4(5), PFKL(2), PFKM(5), PFKP(3), PGM2(5), PHPT1(1), PMM1(1), RDH11(2), SORD(2), TPI1(6), TSTA3(1)	12765147	117	68	115	36	20	34	30	22	11	0	0.37	1.00	1.00
340	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(1), ARHGAP1(3), ARHGAP4(2), ARHGAP5(7), ARHGAP6(6), ARHGEF1(2), ARHGEF11(11), ARHGEF5(4), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), BAIAP2(2), DIAPH1(4), GSN(3), MYL2(2), MYLK(16), OPHN1(6), PFN1(1), PIP5K1A(5), PIP5K1B(7), PPP1R12B(5), ROCK1(10), SRC(2), TLN1(13), VCL(2)	15730697	121	68	120	37	24	32	29	16	20	0	0.59	1.00	1.00
341	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	24	BRCA1(9), CCND1(2), CREBBP(4), EP300(2), ERCC3(5), ESR1(1), GRIP1(6), GTF2A1(3), GTF2E1(6), GTF2F1(1), HDAC1(3), HDAC2(8), HDAC3(1), HDAC4(11), HDAC5(2), HDAC6(5), MEF2C(2), NCOR2(13), NR0B1(5), NRIP1(8), PELP1(2), POLR2A(9), SRA1(2), TBP(1)	15504216	111	67	109	37	24	25	33	15	14	0	0.70	1.00	1.00
342	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	EGF(9), ELK1(2), FOS(1), GRB2(4), HRAS(1), JAK1(8), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), RAF1(3), RASA1(3), SHC1(2), SOS1(12), STAT1(4), STAT3(8), STAT5A(3)	11936625	103	67	100	30	15	19	31	22	16	0	0.52	1.00	1.00
343	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(5), ANAPC10(1), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(3), ANAPC7(4), BTRC(9), CDC16(3), CDC20(3), CDC23(1), CDC27(3), CUL1(6), CUL2(6), CUL3(7), FBXW7(4), FZR1(2), ITCH(6), SKP1(2), SKP2(4), SMURF1(3), SMURF2(2), TCEB1(1), UBA1(1), UBE2D2(1), UBE2D3(4), UBE2D4(3), UBE2E2(1), UBE2E3(1), VHL(1), WWP1(3), WWP2(3)	13918391	97	67	95	24	19	17	26	20	15	0	0.27	1.00	1.00
344	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(3), AKT2(2), AKT3(5), DAG1(2), GNAQ(2), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PDK1(4), PHKA2(10), PIK3CB(7), PITX2(4), PLD1(9), PLD2(5), PLD3(1)	15490934	113	67	112	33	17	32	32	15	17	0	0.35	1.00	1.00
345	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(4), ABP1(10), ACADM(3), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), AOC2(4), AOC3(5), CNDP1(5), DPYD(12), DPYS(10), EHHADH(8), GAD1(5), GAD2(10), HADHA(3), MLYCD(4), SDS(2), SMS(1)	9987148	117	66	116	39	19	39	26	16	15	2	0.74	1.00	1.00
346	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(4), ABAT(4), ACY3(2), ADSSL1(1), AGXT(3), AGXT2(8), ASL(3), ASNS(3), ASPA(2), ASRGL1(1), ASS1(3), CAD(16), CRAT(1), DARS2(3), DDO(3), DLAT(5), DLD(6), GAD1(5), GAD2(10), GOT1(2), GOT2(4), GPT2(3), NARS(3), NARS2(3), PC(1), PDHA1(3), PDHA2(13)	13044756	116	66	116	42	22	31	36	17	10	0	0.73	1.00	1.00
347	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(3), ASAH1(2), B4GALT6(3), CERK(3), DEGS1(3), DEGS2(1), ENPP7(5), GAL3ST1(3), GALC(5), GBA(3), GLA(4), LCT(30), NEU1(1), NEU3(3), NEU4(6), PPAP2B(2), PPAP2C(1), SGMS1(1), SGMS2(3), SGPP1(1), SMPD1(2), SMPD2(1), SMPD3(1), SMPD4(2), SPHK2(2), SPTLC1(1), SPTLC2(1), UGT8(1)	12407907	95	66	94	30	13	33	31	10	8	0	0.48	1.00	1.00
348	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(3), ASRGL1(1), CA1(2), CA12(1), CA13(1), CA14(2), CA2(2), CA3(4), CA4(5), CA5A(4), CA5B(1), CA6(1), CA8(2), CA9(3), CPS1(39), CTH(1), GLS(3), GLS2(2), GLUD1(3), GLUD2(5), GLUL(2), HAL(2)	7318840	91	66	90	38	10	29	23	19	10	0	0.98	1.00	1.00
349	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(5), F2R(4), F2RL3(2), GNAI1(3), GNB1(2), GNGT1(2), HRAS(1), ITGA1(9), ITGB1(3), MAP2K1(6), MAPK3(1), PLA2G4A(10), PLCB1(18), PRKCA(7), PTGS1(5), PTK2(11), RAF1(3), SRC(2), SYK(3), TBXAS1(6)	8377736	103	66	103	27	13	32	20	18	20	0	0.48	1.00	1.00
350	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(7), DIAPH1(4), FYN(3), GSN(3), HRAS(1), ITGA1(9), ITGB1(3), MAP2K1(6), MAPK3(1), MYL2(2), MYLK(16), PFN1(1), PIK3CA(11), PIK3R1(3), PTK2(11), PXN(1), RAF1(3), ROCK1(10), SHC1(2), SRC(2), TLN1(13)	12848503	112	65	107	31	17	28	24	27	16	0	0.44	1.00	1.00
351	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ACTG2(5), ADCY3(5), ADCY9(3), ARF3(1), ARF4(2), ARF5(1), ARL4D(3), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(4), ATP6V1A(4), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), ERO1L(2), GNAS(7), PDIA4(3), PLCG1(5), PLCG2(9), PRKCA(7), SEC61A1(4), SEC61A2(5), SEC61B(1), SEC61G(1), TRIM23(2)	12707439	100	65	99	39	18	26	27	16	13	0	0.91	1.00	1.00
352	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	15	C3(7), C5(2), C6(14), IL1A(3), ITGA4(19), ITGAL(20), ITGB1(3), ITGB2(2), SELP(14), SELPLG(3), VCAM1(16)	8021183	103	65	102	35	9	35	31	15	13	0	0.87	1.00	1.00
353	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(4), ACADM(3), ACAT1(1), ACAT2(1), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), AOX1(14), BCAT1(1), BCKDHB(5), EHHADH(8), HADHA(3), HADHB(4), HIBADH(1), IVD(3), MCCC1(2), MCCC2(3), MCEE(1), MUT(6), OXCT1(4), PCCA(5), PCCB(2), SDS(2)	12378366	104	65	103	37	9	32	28	12	21	2	0.86	1.00	1.00
354	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(10), ASAH1(2), GNAI1(3), GNB1(2), GNGT1(2), ITGAV(9), ITGB3(4), MAPK3(1), PDGFA(6), PDGFRA(17), PIK3CA(11), PIK3R1(3), PLCB1(18), PRKCA(7), PTK2(11), SMPD1(2), SMPD2(1), SRC(2)	9425640	111	64	108	34	15	36	29	13	18	0	0.61	1.00	1.00
355	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(4), ABP1(10), ACADM(3), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(4), AOC3(5), CNDP1(5), DPYD(12), DPYS(10), EHHADH(8), GAD1(5), GAD2(10), HADHA(3), HIBCH(4), MLYCD(4), SMS(1), SRM(2)	9297629	111	64	110	35	17	35	26	16	15	2	0.62	1.00	1.00
356	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGT(2), AGTR1(5), AGTR2(2), CMA1(6), COL4A1(16), COL4A2(16), COL4A3(5), COL4A4(13), COL4A5(23), COL4A6(17), REN(1)	8864361	109	63	109	51	8	52	24	11	14	0	1.00	1.00	1.00
357	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(2), AGTR1(5), ATF2(5), CALM1(2), ELK1(2), GNAQ(2), GRB2(4), HRAS(1), MAP2K1(6), MAP2K2(1), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), PAK1(5), PRKCA(7), PTK2(11), PTK2B(8), RAF1(3), SHC1(2), SOS1(12), SRC(2), SYT1(3)	10651248	100	63	100	28	22	30	17	17	14	0	0.37	1.00	1.00
358	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(4), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH6(8), ADH7(4), ADHFE1(2), AKR1C4(1), AKR1D1(5), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), BAAT(5), CEL(4), CYP27A1(5), CYP7A1(7), HADHB(4), SRD5A1(3), SRD5A2(3)	7989352	114	63	113	36	11	48	24	16	15	0	0.64	1.00	1.00
359	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(6), POLA2(2), POLB(2), POLD1(2), POLD2(2), POLD3(3), POLE(19), POLE2(1), POLG(11), POLG2(1), POLI(2), POLK(3), POLL(2), POLM(6), POLQ(17), PRIM1(3), REV1(4), REV3L(13), RFC5(1)	13796334	100	63	99	26	22	16	35	16	11	0	0.32	1.00	1.00
360	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(16), COL4A2(16), COL4A3(5), COL4A4(13), COL4A5(23), COL4A6(17), P4HB(4), SLC23A2(5), SLC2A3(6)	8821309	105	63	105	45	11	48	20	11	15	0	0.99	1.00	1.00
361	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(6), ABAT(4), ACAT1(1), ACAT2(1), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH5A1(2), ALDH9A1(3), EHHADH(8), GAD1(5), GAD2(10), HADHA(3), L2HGDH(2), OXCT1(4), PDHA1(3), PDHA2(13), SDHB(1), SDS(2)	8839629	96	62	95	32	14	29	25	12	14	2	0.74	1.00	1.00
362	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	24	AKR1B1(2), DCXR(1), GUSB(4), RPE(2), UGDH(4), UGP2(1), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8), XYLB(3)	8738182	102	62	100	33	7	43	25	17	10	0	0.79	1.00	1.00
363	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(3), GTF2A2(1), GTF2B(1), GTF2E1(6), GTF2E2(2), GTF2F1(1), GTF2H1(4), GTF2H3(1), GTF2I(4), GTF2IRD1(5), TAF1(9), TAF10(1), TAF1L(25), TAF2(6), TAF4(4), TAF4B(5), TAF5L(4), TAF6(2), TAF7(2), TAF7L(3), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(3)	12389816	96	62	95	28	16	19	31	14	16	0	0.56	1.00	1.00
364	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(10), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), AOC2(4), AOC3(5), DDC(6), EPX(7), GOT1(2), GOT2(4), HPD(2), LPO(4), MAOA(3), MAOB(1), MPO(4), PRDX1(2), PRDX2(1), PRDX5(1), PRDX6(3), TAT(4), TPO(16)	7565702	87	62	87	30	12	25	23	17	10	0	0.70	1.00	1.00
365	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	39	ASAH1(2), CAMP(2), CREB5(7), CREBBP(4), CRKL(2), DAG1(2), EGR1(2), EGR2(2), EGR3(1), EGR4(2), ELK1(2), FRS2(2), GNAQ(2), MAP1B(11), MAP2K4(3), MAP2K7(2), MAPK10(5), MAPK3(1), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), OPN1LW(3), PIK3C2G(9), PIK3CA(11), PIK3CD(1), PIK3R1(3), RPS6KA3(1), SHC1(2), SRC(2), TH(2)	16435559	105	62	102	41	18	26	36	10	15	0	0.85	1.00	1.00
366	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(4), ACACA(10), ACACB(11), ACADM(3), ACAT1(1), ACAT2(1), ACSS1(4), ACSS2(4), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), EHHADH(8), HADHA(3), HIBCH(4), LDHA(3), LDHAL6A(3), LDHB(2), LDHC(5), MCEE(1), MLYCD(4), MUT(6), PCCA(5), PCCB(2), SUCLG1(2), SUCLG2(2)	13612676	109	61	108	48	21	31	25	12	19	1	0.99	1.00	1.00
367	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(3), CA1(2), CA12(1), CA14(2), CA2(2), CA3(4), CA4(5), CA5A(4), CA5B(1), CA6(1), CA8(2), CA9(3), CPS1(39), CTH(1), GLS(3), GLS2(2), GLUD1(3), GLUL(2), HAL(2)	6542301	84	61	83	34	10	24	22	18	10	0	0.97	1.00	1.00
368	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(7), ATP4B(1), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), ATP7A(14), ATP7B(11), COX4I1(1), COX5B(1), COX6B1(1), COX8A(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(3), NDUFB2(4), NDUFB4(1), NDUFB5(4), NDUFB6(1), NDUFS1(7), NDUFS2(6), NDUFV1(3), SDHA(5), SDHB(1), SHMT1(2), UQCRB(4), UQCRFS1(2)	13158111	117	61	116	51	24	34	26	17	16	0	0.98	1.00	1.00
369	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	FOS(1), GRB2(4), HRAS(1), JAK2(4), MAP2K1(6), MAPK3(1), MPL(2), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), RAF1(3), RASA1(3), SHC1(2), SOS1(12), STAT1(4), STAT3(8), STAT5A(3), STAT5B(4), THPO(1)	10285764	85	61	82	25	11	17	25	19	13	0	0.57	1.00	1.00
370	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	EEF1A2(7), EEF1B2(4), EEF1D(1), EEF1G(2), EEF2(1), EEF2K(2), EIF1AX(1), EIF2AK1(6), EIF2AK2(5), EIF2AK3(6), EIF2B1(1), EIF2B2(2), EIF2B3(3), EIF2B4(3), EIF2B5(3), EIF2S3(2), EIF4A1(2), EIF4A2(4), EIF4E(3), EIF4G1(8), EIF4G3(13), EIF5(2), EIF5B(9), GSPT2(3), PABPC1(4), PAIP1(4)	14706838	101	61	100	27	14	29	37	10	11	0	0.38	1.00	1.00
371	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	BCL2(1), CBL(9), CFLAR(1), CRKL(2), E2F1(3), FOS(1), GRB2(4), HRAS(1), IL2RA(3), IL2RB(5), IL2RG(3), IRS1(15), JAK1(8), JAK3(5), MAPK3(1), NMI(1), PIK3CA(11), PIK3R1(3), PTPN6(3), RAF1(3), RPS6KB1(2), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4), SYK(3)	12429891	109	60	105	36	23	18	33	23	12	0	0.52	1.00	1.00
372	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT2(2), AKT3(5), BCL2(1), GRB2(4), GSK3B(2), IL4R(5), IRS1(15), IRS2(3), JAK1(8), JAK3(5), MAP4K1(5), MAPK3(1), PDK1(4), PIK3CA(11), PIK3CD(1), PIK3R1(3), PPP1R13B(2), RAF1(3), SHC1(2), SOS1(12), SOS2(6), STAT6(2)	12566375	102	60	99	37	16	20	32	21	13	0	0.76	1.00	1.00
373	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(2), GNAQ(2), GNAS(7), GNB1(2), GNGT1(2), HRAS(1), MAP2K1(6), MAPK3(1), MYL2(2), NOX1(3), PIK3C2G(9), PLCB1(18), PPP1R12B(5), PRKCA(7), PTK2(11), RAF1(3), ROCK2(4)	8767494	85	59	85	24	14	25	20	11	15	0	0.60	1.00	1.00
374	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4A1(2), EIF4A2(4), EIF4E(3), EIF4G1(8), EIF4G3(13), GHR(5), IRS1(15), MAPK14(1), MAPK3(1), MKNK1(2), PABPC1(4), PDK2(2), PDPK1(1), PIK3CA(11), PIK3R1(3), PRKCA(7), PTEN(8), RPS6KB1(2)	9649373	92	59	88	32	15	21	34	12	10	0	0.79	1.00	1.00
375	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(2), ANXA2(2), ANXA3(3), ANXA4(3), ANXA5(2), ANXA6(1), CYP11A1(1), EDN1(1), EDNRB(6), HPGD(1), HSD11B1(4), HSD11B2(1), PLA2G4A(10), PRL(1), PTGDR(3), PTGDS(2), PTGER2(2), PTGER4(7), PTGFR(6), PTGIR(2), PTGIS(5), PTGS1(5), PTGS2(4), TBXAS1(6)	7115488	80	59	80	30	12	22	21	11	14	0	0.89	1.00	1.00
376	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2(5), F2R(4), F3(4), F5(23), F7(2), FGA(9), FGB(13), FGG(2), PROC(3), PROS1(13), SERPINC1(8), TFPI(1)	5624927	90	58	89	28	11	36	19	10	13	1	0.80	1.00	1.00
377	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	ACTA1(4), CAPN2(3), CAPNS2(2), CXCR3(1), EGF(9), HRAS(1), ITGA1(9), ITGB1(3), MAPK3(1), MYL2(2), MYLK(16), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PTK2(11), PXN(1), TLN1(13)	10370265	88	58	87	26	10	26	18	19	15	0	0.56	1.00	1.00
378	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(2), GHR(5), GRB2(4), HRAS(1), INSR(1), IRS1(15), JAK2(4), MAP2K1(6), MAPK3(1), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), PTPN6(3), RAF1(3), RPS6KA1(1), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4)	11358400	93	57	90	30	18	19	26	20	10	0	0.57	1.00	1.00
379	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(1), CDK7(3), ERCC3(5), GTF2A2(1), GTF2B(1), GTF2E1(6), GTF2E2(2), GTF2H1(4), ILK(1), MNAT1(2), POLR1A(8), POLR1B(10), POLR2A(9), POLR2B(5), POLR2C(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR3B(15), POLR3D(2), POLR3E(2), POLR3H(1), TAF6(2), TAF7(2), TAF9(2), TBP(1)	12033034	94	57	91	37	17	22	33	13	9	0	0.92	1.00	1.00
380	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(10), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), GNAS(7), GRB2(4), HRAS(1), MAPK14(1), MAPK3(1), PIK3CA(11), PIK3R1(3), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), RPS6KA1(1), RPS6KA5(4), SOS1(12)	9983942	82	56	79	32	11	21	24	15	11	0	0.93	1.00	1.00
381	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(10), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH9A1(3), AOC2(4), AOC3(5), ASPA(2), CNDP1(5), DDC(6), HAL(2), HARS(2), HDC(7), HNMT(2), MAOA(3), MAOB(1), PRPS1(3), PRPS2(2)	8440940	89	56	89	28	16	25	22	16	10	0	0.49	1.00	1.00
382	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CYP2C19(9), CYP2C9(3), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), EHHADH(8), ESCO1(7), ESCO2(2), HADHA(3), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), SH3GLB1(1), YOD1(1)	10627890	84	56	83	26	12	26	20	14	11	1	0.61	1.00	1.00
383	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(2), ITGA4(19), ITGAL(20), ITGAM(14), ITGB1(3), ITGB2(2), SELE(6), SELL(4), SELP(14)	5528060	84	56	84	31	9	30	25	13	7	0	0.92	1.00	1.00
384	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(7), ARHGEF1(2), GNA12(1), GNA13(5), GNAQ(2), GNB1(2), GNGT1(2), MYL2(2), MYLK(16), PLCB1(18), PPP1R12B(5), PRKCA(7), ROCK1(10)	7129686	79	56	78	20	10	28	19	8	14	0	0.45	1.00	1.00
385	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(1), BLVRB(1), CP(7), CPOX(4), EPRS(13), FECH(2), GUSB(4), HMBS(3), HMOX1(3), PPOX(3), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2B15(6), UGT2B4(13)	9435487	92	56	91	28	7	34	23	17	11	0	0.67	1.00	1.00
386	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(9), EGF(9), GRB2(4), HRAS(1), MAP2K1(6), MAPK3(1), PTPRB(30), RAF1(3), RASA1(3), SHC1(2), SOS1(12), SPRY1(1), SPRY2(2), SPRY3(5), SPRY4(3), SRC(2)	7690049	93	56	93	29	15	24	20	22	12	0	0.62	1.00	1.00
387	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(11), DLG4(3), EPHB2(7), F2(5), F2RL1(1), F2RL2(5), F2RL3(2), MAPK7(5), MAPK8(3), MYEF2(4), PLD1(9), PLD2(5), PLD3(1), PTK2(11), RAF1(3), RASAL1(7), SRC(2), TEC(5), VAV1(1)	9471669	90	56	90	22	12	23	29	15	11	0	0.17	1.00	1.00
388	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(2), ACTN2(23), ACTN3(3), CAPNS2(2), ITGA1(9), ITGB1(3), ITGB3(4), PTK2(11), PXN(1), SPTAN1(12), SRC(2), TLN1(13)	9819062	89	56	88	35	18	26	12	22	11	0	0.93	1.00	1.00
389	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(8), BAX(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP2(7), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), FADD(1), FAS(3), FASLG(4), GZMB(3), MAP2K4(3), MAP3K1(4), MAP3K14(1), MAPK10(5), MCL1(1), MDM2(2), NFKB1(3), NFKBIA(1), PARP1(2), PRF1(5), RIPK1(4), TNFRSF1B(1), TNFSF10(1), TRAF2(1)	12612862	81	55	81	30	9	23	17	16	16	0	0.91	1.00	1.00
390	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(4), F13A1(13), F2(5), F2R(4), FGA(9), FGB(13), FGG(2), PLAT(6), PLAU(1), PLG(13), SERPINB2(6), SERPINE1(5)	4602900	81	55	80	28	7	36	19	12	7	0	0.91	1.00	1.00
391	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	CABIN1(5), CALM1(2), CAMK1(2), HDAC5(2), IGF1(5), IGF1R(10), INSR(1), MAP2K6(1), MAPK14(1), MAPK7(5), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), MYOD1(5), NFATC1(3), NFATC2(8), PIK3CA(11), PIK3R1(3), PPP3CB(1), PPP3CC(2), SYT1(3)	11608468	76	55	73	23	8	26	21	8	13	0	0.46	1.00	1.00
392	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(4), ACACA(10), ACADM(3), ACAT1(1), ACAT2(1), ALDH1A1(3), ALDH1A2(8), ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), EHHADH(8), HADHA(3), LDHA(3), LDHB(2), LDHC(5), MCEE(1), MLYCD(4), MUT(6), PCCA(5), PCCB(2), SDS(2), SUCLG1(2), SUCLG2(2)	11345347	95	55	94	34	17	27	24	9	17	1	0.86	1.00	1.00
393	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(5), BCR(3), BLNK(1), ELK1(2), FOS(1), GRB2(4), HRAS(1), LYN(4), MAP2K1(6), MAP3K1(4), MAPK3(1), MAPK8IP3(4), PAPPA(12), RPS6KA1(1), RPS6KA3(1), SHC1(2), SOS1(12), SYK(3), VAV1(1), VAV2(3), VAV3(14)	11049708	85	55	85	34	9	24	20	19	13	0	0.93	1.00	1.00
394	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(1), ARSD(3), ASAH1(2), GAL3ST1(3), GALC(5), GBA(3), GLA(4), LCT(30), NEU1(1), NEU3(3), NEU4(6), PPAP2B(2), PPAP2C(1), SMPD1(2), SMPD2(1), SPTLC1(1), SPTLC2(1)	8402010	70	54	69	20	9	26	25	5	5	0	0.35	1.00	1.00
395	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	ELK1(2), FOS(1), GRB2(4), HRAS(1), IGF1(5), IGF1R(10), IRS1(15), MAP2K1(6), MAPK3(1), MAPK8(3), PIK3CA(11), PIK3R1(3), RAF1(3), RASA1(3), SHC1(2), SOS1(12)	8063548	82	54	79	23	16	19	22	15	10	0	0.36	1.00	1.00
396	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4A1(2), EIF4A2(4), EIF4B(5), EIF4E(3), EIF4G1(8), EIF4G3(13), MKNK1(2), PDK2(2), PDPK1(1), PIK3CA(11), PIK3R1(3), PPP2CA(1), PTEN(8), RPS6KB1(2), TSC1(9), TSC2(4)	9543117	78	54	73	23	7	21	31	11	8	0	0.51	1.00	1.00
397	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(2), CALM1(2), CRKL(2), GNAQ(2), GRB2(4), HRAS(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP3K1(4), MAPK14(1), MAPK3(1), MAPK8(3), PAK1(5), PLCG1(5), PRKCA(7), PTK2B(8), RAF1(3), SHC1(2), SOS1(12), SRC(2), SYT1(3)	9781964	85	54	85	26	22	25	16	11	11	0	0.45	1.00	1.00
398	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(23), CDH1(5), CREBBP(4), EP300(2), MAP2K1(6), MAP3K7(5), MAPK3(1), SKIL(7), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2)	8789936	68	54	68	16	3	19	14	16	16	0	0.47	1.00	1.00
399	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(10), CD3D(2), CD4(3), CREBBP(4), GNAS(7), GNB1(2), GNGT1(2), HLA-DRA(3), LCK(5), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PTPRC(21), ZAP70(4)	7926835	75	53	75	26	6	26	23	6	14	0	0.83	1.00	1.00
400	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	APAF1(8), ATM(22), BAX(1), BCL2(1), BID(1), CASP3(4), CASP6(1), CASP7(1), CASP9(3), PRKCA(7), PTK2(11), PXN(1), STAT1(4), TLN1(13)	9164809	78	53	77	27	10	20	16	15	17	0	0.83	1.00	1.00
401	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(10), CD3D(2), CD4(3), CREBBP(4), GNAS(7), GNB1(2), GNGT1(2), HLA-DRA(3), LCK(5), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PTPRC(21), ZAP70(4)	7926835	75	53	75	26	6	26	23	6	14	0	0.83	1.00	1.00
402	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), FPGT(2), GCK(4), GMDS(6), GMPPA(5), GMPPB(1), HK1(3), HK2(9), HK3(12), KHK(2), PFKFB1(6), PFKFB3(5), PFKFB4(5), PFKM(5), PFKP(3), PMM1(1), SORD(2), TPI1(6)	8314532	87	53	85	26	18	25	21	15	8	0	0.32	1.00	1.00
403	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(1), CREBBP(4), EP300(2), FYN(3), IL2RG(3), IL7R(7), JAK1(8), JAK3(5), LCK(5), NMI(1), PIK3CA(11), PIK3R1(3), PTK2B(8), STAT5A(3), STAT5B(4)	9665403	68	53	64	24	9	14	19	16	10	0	0.81	1.00	1.00
404	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	BCL2(1), IGF1R(10), POLR2A(9), PPP2CA(1), PRKCA(7), RB1(13), TEP1(23), TERF1(1), TERT(4), TNKS(3), XRCC5(6)	8476435	78	53	78	26	16	18	15	8	21	0	0.69	1.00	1.00
405	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(2), CXCL12(1), CXCR4(3), GNAI1(3), GNAQ(2), GNB1(2), GNGT1(2), HRAS(1), MAP2K1(6), MAPK3(1), NFKB1(3), PIK3C2G(9), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), PTK2(11), PTK2B(8), PXN(1), RAF1(3)	9569910	84	52	81	19	15	23	21	11	14	0	0.13	1.00	1.00
406	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCL2(1), BCR(3), CRKL(2), FOS(1), GRB2(4), HRAS(1), JAK2(4), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), PIK3CA(11), PIK3R1(3), RAF1(3), SOS1(12), STAT1(4), STAT5A(3), STAT5B(4)	9611359	73	52	70	20	10	11	23	16	13	0	0.31	1.00	1.00
407	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GUSB(4), HEXA(1), HGSNAT(4), HPSE(1), HPSE2(6), HYAL1(1), HYAL2(1), IDS(3), IDUA(2), LCT(30), NAGLU(1), SPAM1(12)	7051597	67	52	67	23	7	24	20	8	8	0	0.75	1.00	1.00
408	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(3), EXT2(7), EXTL1(3), EXTL3(5), GLCE(4), HS3ST1(2), HS3ST2(2), HS3ST3A1(4), HS3ST3B1(1), HS3ST5(9), HS6ST1(1), HS6ST2(1), HS6ST3(5), NDST1(2), NDST2(7), NDST3(8), NDST4(13)	7153731	77	52	76	36	8	24	28	9	7	1	0.98	1.00	1.00
409	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(3), ACAD9(3), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(6), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(7), ESCO2(2), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), SH3GLB1(1)	8604904	89	52	89	27	7	45	12	13	12	0	0.75	1.00	1.00
410	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(3), ABP1(10), AOC2(4), AOC3(5), CES1(3), CES7(9), DDHD1(3), ESCO1(7), ESCO2(2), LIPA(2), MYST3(8), MYST4(8), NAT6(1), PLA1A(4), PNPLA3(2), PPME1(3), PRDX6(3), SH3GLB1(1)	8709557	78	52	78	21	11	26	17	13	11	0	0.50	1.00	1.00
411	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(3), IFNB1(4), IKBKB(3), IL1A(3), IL1R1(1), IL1RAP(2), IL1RN(1), IRAK1(3), IRAK2(3), IRAK3(6), MAP2K3(6), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAP3K7(5), MAPK14(1), MAPK8(3), MYD88(3), NFKB1(3), NFKBIA(1), TGFB1(2), TGFB2(8), TGFB3(1), TOLLIP(1), TRAF6(4)	10174928	73	52	72	33	10	19	16	14	14	0	0.99	1.00	1.00
412	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(3), FADD(1), IKBKB(3), IL1A(3), IL1R1(1), IRAK1(3), MAP3K1(4), MAP3K14(1), MAP3K7(5), MYD88(3), NFKB1(3), NFKBIA(1), RIPK1(4), TLR4(31), TNFRSF1B(1), TRAF6(4)	8407048	71	52	70	27	8	18	20	11	14	0	0.89	1.00	1.00
413	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	CDC42(2), CREB5(7), DUSP10(6), EEF2K(2), EIF4E(3), ELK1(2), GADD45A(1), HSPB1(1), IL1R1(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP3K10(1), MAP3K4(14), MAP3K5(12), MAP3K7(5), MAPK11(1), MAPK14(1), MAPKAPK2(3), MAPKAPK5(3), MKNK1(2), MKNK2(1), MYEF2(4), NFKB1(3), NR2C2(2), TRAF6(4)	11449542	91	52	90	28	20	24	23	11	13	0	0.59	1.00	1.00
414	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), DAG1(2), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), NFAT5(6), PDE6A(9), PDE6B(4), PDE6C(5), PDE6D(1), PDE6G(2), SLC6A13(4), TF(4)	12435387	93	52	92	28	15	31	17	17	13	0	0.55	1.00	1.00
415	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(4), CR1(16), CR2(8), FCGR2B(2), HLA-DRA(3), ITGAL(20), ITGB2(2), PTPRC(21)	5287839	76	51	75	24	8	29	15	8	16	0	0.80	1.00	1.00
416	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(8), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP10(6), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(3), DFFA(3), DFFB(2), FADD(1), GAS2(1), MAP3K14(1), NFKB1(3), NFKBIA(1), RIPK1(4), SPTAN1(12), TNFRSF10B(1), TNFRSF25(1), TNFSF10(1), TRAF2(1)	11580988	70	51	70	34	12	14	19	10	15	0	0.99	1.00	1.00
417	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(2), ALDOB(4), ALDOC(1), DERA(1), FBP2(1), G6PD(2), GPI(3), H6PD(3), PFKL(2), PFKM(5), PFKP(3), PGD(2), PGM1(2), PGM3(4), PRPS1(3), PRPS1L1(3), PRPS2(2), RPE(2), RPIA(5), TKT(1), TKTL1(10), TKTL2(12)	8405445	73	51	72	24	14	19	17	14	9	0	0.60	1.00	1.00
418	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), CS(1), DLAT(5), DLD(6), DLST(2), FH(7), IDH2(2), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(2), MDH2(2), OGDH(1), PC(1), PDHA1(3), PDHA2(13), PDHX(4), PDK1(4), PDK2(2), PDK3(2), PDP2(1), SDHA(5), SDHB(1), SDHD(1), SUCLG1(2), SUCLG2(2)	9740515	75	51	75	34	13	21	19	11	11	0	0.96	1.00	1.00
419	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(3), MAP2K7(2), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), MAPKAPK5(3), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PIK3CA(11), PIK3CD(1), PIK3R1(3), SYT1(3), TRAF2(1), TRAF3(3), TRAF5(2), TRAF6(4)	11610987	72	51	68	27	12	12	28	8	12	0	0.71	1.00	1.00
420	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	11	CBL(9), CSF1R(6), EGF(9), GRB2(4), MET(12), PDGFRA(17), PRKCA(7), SH3GLB1(1), SH3GLB2(1), SH3KBP1(2), SRC(2)	5745152	70	50	70	24	10	19	16	13	12	0	0.78	1.00	1.00
421	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(8), POLR1B(10), POLR1D(2), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLR3A(12), POLR3B(15), POLR3G(1), POLR3H(1)	8089883	77	50	75	26	15	16	27	13	6	0	0.69	1.00	1.00
422	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCL4(1), CCR1(2), CCR2(5), CCR3(2), CCR4(2), CCR5(1), CD28(1), CD4(3), CXCR3(1), CXCR4(3), IFNG(4), IFNGR1(3), IFNGR2(3), IL12A(3), IL12RB1(3), IL12RB2(12), IL18R1(3), IL2(5), IL4(1), IL4R(5), TGFB1(2), TGFB2(8), TGFB3(1)	6867481	75	50	74	24	7	21	20	13	14	0	0.53	1.00	1.00
423	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), DAB1(15), FYN(3), LRP8(3), RELN(49), VLDLR(2)	4832816	73	50	72	27	4	26	17	16	10	0	0.96	1.00	1.00
424	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACLY(2), ACO1(4), ACO2(1), CLYBL(5), CS(1), DLD(6), DLST(2), FH(7), IDH1(2), IDH2(2), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(2), MDH2(2), OGDH(1), OGDHL(11), PC(1), PCK2(3), SDHA(5), SDHB(1), SDHD(1), SUCLG1(2), SUCLG2(2)	9768453	68	49	68	36	11	11	20	13	13	0	0.99	1.00	1.00
425	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(2), AMD1(1), BHMT(6), CBS(1), CTH(1), DNMT1(5), DNMT3A(11), DNMT3B(4), MARS(2), MARS2(8), MAT1A(4), MAT2B(3), MTFMT(1), MTR(11), SRM(2), TAT(4)	7191974	66	49	66	20	13	18	21	8	5	1	0.45	1.00	1.00
426	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA1(1), FUCA2(1), HEXA(1), LCT(30), MAN2B1(2), MAN2B2(3), MAN2C1(4), MANBA(4), NEU1(1), NEU3(3), NEU4(6)	7070604	57	49	57	15	7	21	20	6	3	0	0.32	1.00	1.00
427	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	CREB5(7), DUSP6(3), DUSP9(2), EEF2K(2), EIF4E(3), GRB2(4), MAP2K1(6), MAP2K2(1), MAP3K8(2), MAPK3(1), MKNK1(2), MKNK2(1), MOS(2), NFKB1(3), RAP1A(2), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), SHC1(2), SOS1(12), SOS2(6), TRAF3(3)	9698379	73	49	73	29	8	16	27	12	10	0	0.89	1.00	1.00
428	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	11	DNM1(5), GABRA1(8), GABRA2(14), GABRA3(8), GABRA4(10), GABRA6(12), GPHN(3), NSF(3), SRC(2), UBQLN1(5)	3827048	70	48	68	22	11	27	10	14	8	0	0.78	1.00	1.00
429	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(3), ATG7(1), BECN1(1), GABARAPL1(1), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(4), IFNA8(1), IFNG(4), PIK3C3(7), PIK3R4(9), PRKAA1(4), ULK1(3), ULK2(2), ULK3(1)	7295711	67	48	67	23	6	25	18	14	4	0	0.86	1.00	1.00
430	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(10), ACE2(3), AGT(2), AGTR1(5), AGTR2(2), ANPEP(4), CMA1(6), CPA3(6), CTSA(1), CTSG(2), ENPEP(8), LNPEP(1), MAS1(3), MME(8), NLN(5), REN(1), THOP1(2)	7310825	69	48	69	34	6	24	24	6	9	0	0.99	1.00	1.00
431	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	ELK1(2), FOS(1), GRB2(4), HRAS(1), IL6R(8), JAK1(8), JAK2(4), JAK3(5), MAP2K1(6), MAPK3(1), RAF1(3), SHC1(2), SOS1(12), STAT3(8)	7823556	65	48	65	20	9	13	16	21	6	0	0.57	1.00	1.00
432	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(12), APOA1(1), APOA4(3), APOC2(1), APOC3(3), APOE(1), CETP(2), CYP7A1(7), DGAT1(2), HMGCR(4), LCAT(1), LDLR(4), LIPC(6), LPL(5), LRP1(21), SOAT1(7)	9394267	80	48	79	33	17	19	19	18	6	1	0.92	1.00	1.00
433	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(1), EPRS(13), FARS2(1), GARS(4), HARS(2), IARS(9), KARS(4), LARS(7), LARS2(2), MARS(2), MARS2(8), NARS(3), QARS(2), RARS(5), SARS(2), TARS(5), WARS(3), WARS2(9), YARS(1)	11020854	84	47	84	26	11	29	21	17	6	0	0.71	1.00	1.00
434	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(3), CHAT(8), DBH(2), DDC(6), GAD1(5), GAD2(10), HDC(7), MAOA(3), PAH(3), SLC18A3(8), TH(2), TPH1(11)	4997467	68	47	68	24	14	16	13	16	9	0	0.75	1.00	1.00
435	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(2), AZIN1(1), BTG1(1), CBX3(2), CLOCK(2), CRY1(3), CRY2(2), DAZAP2(1), ETV6(4), GFRA1(8), GSTM3(1), GSTP1(2), HERPUD1(2), HSPA8(3), IDI1(1), MYF6(6), NCKAP1(4), NCOA4(4), NR1D2(2), PER1(3), PER2(4), PPP1R3C(1), PPP2CB(3), PSMA4(1), PURA(1), SF3A3(1), SUMO3(1), TOB1(1), UCP3(1), UGP2(1), VAPA(1), ZFR(5)	12668509	75	47	75	31	14	23	23	5	10	0	0.97	1.00	1.00
436	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(1), AGPS(3), ENPP2(10), ENPP6(2), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLD1(9), PLD2(5), PPAP2B(2), PPAP2C(1)	8004237	75	47	75	26	12	28	19	8	8	0	0.77	1.00	1.00
437	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	30	ALOX15(4), ALOX5(6), CYP1A2(2), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2J2(8), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(4), HSD3B7(2), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), RDH11(2)	7996222	81	47	81	35	17	30	17	8	8	1	0.95	1.00	1.00
438	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(4), HEXA(1), LCT(30), SLC33A1(2), ST3GAL1(3), ST3GAL2(3), ST6GALNAC3(8), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(4)	5647369	62	47	62	19	11	14	24	7	6	0	0.50	1.00	1.00
439	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	ELK1(2), FOS(1), GRB2(4), HRAS(1), IL2(5), IL2RA(3), IL2RB(5), IL2RG(3), JAK1(8), JAK3(5), LCK(5), MAP2K1(6), MAPK3(1), MAPK8(3), RAF1(3), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4), SYK(3)	8085303	79	47	77	25	13	18	18	21	9	0	0.57	1.00	1.00
440	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(20), ATM(22), BAX(1), CDKN1A(1), CPB2(4), CSNK1A1(1), CSNK1D(2), GADD45A(1), HIF1A(1), IGFBP3(2), MAPK8(3), MDM2(2), NQO1(3)	6884198	63	47	61	16	9	18	14	9	13	0	0.52	1.00	1.00
441	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG1(1), ASL(3), CKM(1), CKMT1A(2), CKMT1B(1), CKMT2(2), CPS1(39), GATM(4), GLUD1(3), OAT(1), ODC1(1), OTC(5), SMS(1)	5990411	65	47	64	24	8	17	17	13	10	0	0.87	1.00	1.00
442	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	9	ACTA1(4), EPHA4(9), FYN(3), ITGA1(9), ITGB1(3), L1CAM(14), LYN(4), RAP1B(1), SELP(14)	4715339	61	46	59	18	8	15	14	19	5	0	0.71	1.00	1.00
443	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(6), DDX20(1), E2F1(3), ETS1(7), ETS2(3), FOS(1), HDAC2(8), HDAC5(2), HRAS(1), NCOR2(13), RBL1(7), RBL2(2), SIN3A(6)	8949778	61	46	61	25	6	11	22	12	10	0	0.92	1.00	1.00
444	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(14), CD38(3), ENPP1(6), ENPP3(12), NADK(2), NADSYN1(1), NMNAT1(1), NMNAT2(3), NMNAT3(1), NNMT(5), NNT(4), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5E(2), NT5M(1), NUDT12(2), QPRT(2)	7433340	65	46	65	27	7	24	16	11	7	0	0.95	1.00	1.00
445	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(4), BAIAP2(2), CASP1(2), CASP3(4), CASP7(1), CASP8(4), GAPDH(3), INSR(1), ITCH(6), MAGI1(16), MAGI2(15), RERE(10), WWP1(3), WWP2(3)	8282472	74	46	73	23	16	24	18	8	8	0	0.59	1.00	1.00
446	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	ELK1(2), FOS(1), GRB2(4), HRAS(1), INSR(1), IRS1(15), MAP2K1(6), MAPK3(1), MAPK8(3), PIK3CA(11), PIK3R1(3), RAF1(3), RASA1(3), SHC1(2), SOS1(12)	8322089	68	46	65	21	14	12	20	16	6	0	0.47	1.00	1.00
447	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(10), BAX(1), BCL2(1), CSF2RB(5), IGF1(5), IGF1R(10), IL3(1), IL3RA(5), KIT(6), PIK3CA(11), PIK3R1(3), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1)	7509597	70	45	67	25	8	21	24	7	10	0	0.70	1.00	1.00
448	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM1(2), CDKN1A(1), GNAQ(2), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), PLCG1(5), PPP3CB(1), PPP3CC(2), PRKCA(7), SP1(1), SP3(4), SYT1(3)	6817330	57	45	57	18	11	17	18	5	6	0	0.47	1.00	1.00
449	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QA(1), C1QB(2), C1R(1), C1S(1), C2(3), C3(7), C5(2), C6(14), C8A(6), C8B(9), C9(11), MASP1(5)	6667106	62	45	61	29	6	23	15	8	10	0	0.99	1.00	1.00
450	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	25	AHCY(2), CBS(1), CTH(1), GGT1(1), LCMT1(2), LCMT2(4), MARS(2), MARS2(8), MAT1A(4), MAT2B(3), METTL2B(5), METTL6(1), PAPSS1(3), PAPSS2(4), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), SCLY(2), SEPHS1(4), WBSCR22(1)	8213314	71	45	71	21	18	16	28	3	6	0	0.28	1.00	1.00
451	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(3), GALNT10(3), GALNT2(4), GALNT3(4), GALNT4(4), GALNT6(2), GALNT7(5), GALNT8(6), GALNT9(1), GCNT1(4), ST3GAL1(3), ST3GAL2(3), ST3GAL4(2), WBSCR17(16)	4952583	60	45	60	30	16	10	18	12	4	0	0.98	1.00	1.00
452	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	26	CALM1(2), CHUK(3), EGR2(2), EGR3(1), GNAQ(2), MAP3K1(4), NFATC1(3), NFATC2(8), NFKB1(3), NFKBIA(1), PLCG1(5), PPP3CB(1), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), SYT1(3), VIP(1), VIPR2(4)	9221143	57	45	57	17	9	17	16	2	13	0	0.46	1.00	1.00
453	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(2), ACP2(1), ACP5(3), ACP6(3), ACPP(7), ALPI(5), ALPL(2), ALPP(4), ALPPL2(3), CMBL(1), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(4), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), PON1(3), PON3(5)	6216434	54	44	54	28	5	11	19	9	10	0	0.97	1.00	1.00
454	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	GRB2(4), HRAS(1), IGF1R(10), IRS1(15), MAP2K1(6), MAPK3(1), PIK3CA(11), PIK3R1(3), RAF1(3), SHC1(2), SOS1(12)	6468334	68	44	65	19	13	17	17	15	6	0	0.38	1.00	1.00
455	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	ELK1(2), FOS(1), GRB2(4), HRAS(1), KLK2(4), MAP2K1(6), MAPK3(1), MAPK8(3), NGFR(2), PIK3CA(11), PIK3R1(3), PLCG1(5), RAF1(3), SHC1(2), SOS1(12)	6555125	60	44	57	16	9	16	19	12	4	0	0.33	1.00	1.00
456	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), HLA-A(2), ITGB1(3), KLRC1(3), KLRC2(3), KLRC3(3), KLRD1(2), LAT(3), MAP2K1(6), MAPK3(1), PAK1(5), PIK3CA(11), PIK3R1(3), PTK2B(8), PTPN6(3), SYK(3), VAV1(1)	6399176	61	44	58	17	12	9	18	13	9	0	0.32	1.00	1.00
457	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), DCXR(1), GUSB(4), RPE(2), UCHL1(1), UGDH(4), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2B15(6), UGT2B4(13)	6090026	63	44	62	23	6	21	15	12	9	0	0.82	1.00	1.00
458	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), DYRK1B(2), GLI2(10), GLI3(17), GSK3B(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), SHH(4), SMO(5)	5808356	55	44	55	16	14	17	9	6	9	0	0.43	1.00	1.00
459	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(4), AGXT(3), AGXT2(8), ASL(3), ASNS(3), ASPA(2), CAD(16), CRAT(1), DDO(3), GAD1(5), GAD2(10), GOT1(2), GOT2(4), GPT2(3), NARS(3), PC(1)	8995349	72	43	72	31	15	17	21	12	7	0	0.90	1.00	1.00
460	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(2), BHMT(6), CBS(1), CTH(1), DNMT1(5), DNMT3A(11), DNMT3B(4), MARS(2), MARS2(8), MAT1A(4), MAT2B(3), MTR(11)	6019952	58	43	58	16	10	16	19	7	5	1	0.33	1.00	1.00
461	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AP2A1(2), AP2M1(5), BTK(11), EEA1(6), GSK3B(2), LYN(4), PDPK1(1), PFKL(2), PFKM(5), PFKP(3), PLCG1(5), PRKCE(3), PRKCZ(2), RAB5A(1), RPS6KB1(2), VAV2(3)	8585210	57	43	56	19	10	11	19	11	6	0	0.65	1.00	1.00
462	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6R(8), JAK1(8), JAK2(4), JAK3(5), PIAS3(6), PTPRU(10), REG1A(9), SRC(2), STAT3(8)	5302724	60	43	59	18	9	18	12	13	8	0	0.60	1.00	1.00
463	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(8), BIRC2(2), BIRC3(3), CASP1(2), CASP10(6), CASP2(7), CASP3(4), CASP4(3), CASP6(1), CASP7(1), CASP8(4), CASP9(3), DFFA(3), DFFB(2), GZMB(3), LMNB1(2), LMNB2(2), PRF1(5)	6681762	61	42	61	20	8	19	13	11	10	0	0.81	1.00	1.00
464	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K6(1), MAP3K1(4), MAPK14(1), MAPK3(1), NFKB1(3), PIK3CA(11), PIK3R1(3), RB1(13), SP1(1)	6670312	51	42	48	14	4	12	11	7	17	0	0.63	1.00	1.00
465	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(4), IL22(2), IL22RA2(2), JAK1(8), JAK2(4), JAK3(5), STAT1(4), STAT3(8), STAT5A(3), STAT5B(4), TYK2(2)	6383833	46	42	46	17	3	8	9	16	10	0	0.85	1.00	1.00
466	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(1), CD3D(2), CD80(4), CD86(6), CTLA4(1), GRB2(4), HLA-DRA(3), ICOS(2), IL2(5), ITK(7), LCK(5), PIK3CA(11), PIK3R1(3)	3960784	54	41	50	16	4	14	16	10	10	0	0.67	1.00	1.00
467	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	8	GABRA1(8), GABRA2(14), GABRA3(8), GABRA4(10), GABRA6(12), GPX1(1), PRKCE(3)	2448239	56	41	55	20	6	27	8	11	4	0	0.91	1.00	1.00
468	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(2), ITGA4(19), ITGAL(20), ITGB1(3), ITGB2(2), SELE(6), SELL(4)	4197341	56	41	56	22	7	19	15	8	7	0	0.94	1.00	1.00
469	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	BCAR1(2), CDKN1B(3), GRB2(4), ILK(1), ITGB1(3), MAPK3(1), PDK2(2), PDPK1(1), PIK3CA(11), PIK3R1(3), PTEN(8), PTK2(11), SHC1(2), SOS1(12)	6648557	64	41	60	16	6	16	18	14	10	0	0.40	1.00	1.00
470	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT2(2), AKT3(5), BPNT1(3), GRB2(4), ILK(1), MAPK3(1), PDK1(4), PIK3CA(11), PIK3CD(1), PTEN(8), PTK2B(8), RBL2(2), SHC1(2), SOS1(12)	7004194	64	41	60	22	10	16	20	12	6	0	0.75	1.00	1.00
471	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(2), ACTN2(23), ACTN3(3), BCAR1(2), CTNNA1(3), CTNNB1(11), PTK2(11), PXN(1), SRC(2), VCL(2)	5975297	60	40	57	19	11	21	8	15	5	0	0.59	1.00	1.00
472	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	ELK1(2), EPO(3), EPOR(1), FOS(1), GRB2(4), HRAS(1), JAK2(4), MAP2K1(6), MAPK3(1), MAPK8(3), PLCG1(5), PTPN6(3), RAF1(3), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4)	7393494	58	40	58	19	10	13	15	14	6	0	0.55	1.00	1.00
473	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(1), ACAT2(1), ACOT11(2), ACYP2(1), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), EHHADH(8), ESCO1(7), ESCO2(2), GCDH(3), HADHA(3), ITGB1BP3(2), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), SH3GLB1(1), YOD1(1)	8925504	59	40	57	16	7	18	16	8	9	1	0.48	1.00	1.00
474	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(4), CAT(3), EPX(7), LPO(4), MPO(4), PRDX1(2), PRDX2(1), PRDX5(1), PRDX6(3), SHMT1(2), SHMT2(2), TPO(16)	4053300	49	40	49	15	6	15	12	10	6	0	0.54	1.00	1.00
475	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(3), CREBBP(4), EP300(2), IKBKB(3), MAP2K3(6), MAP2K6(1), MAP3K14(1), MAP3K7(5), MAPK11(1), MAPK14(1), MYD88(3), NFKB1(3), NFKBIA(1), NR3C1(3), TGFBR1(2), TGFBR2(2), TLR2(2)	10176531	43	40	43	22	3	9	13	5	13	0	0.99	1.00	1.00
476	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(5), GTF2A1(3), GTF2B(1), GTF2E1(6), GTF2F1(1), HDAC3(1), NCOA1(5), NCOA2(6), NCOA3(8), NCOR2(13), POLR2A(9), RARA(3), RXRA(1), TBP(1)	8569867	63	40	62	29	17	18	12	12	4	0	0.97	1.00	1.00
477	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(5), CHUK(3), IFNG(4), IKBKB(3), IL2(5), IL4(1), MAP3K1(4), MAP3K5(12), MAP4K5(1), MAPK14(1), MAPK8(3), NFKB1(3), NFKBIA(1), TNFRSF9(4), TNFSF9(1), TRAF2(1)	6665503	52	39	51	14	7	11	14	5	15	0	0.49	1.00	1.00
478	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	13	C1QA(1), C1QB(2), C1R(1), C1S(1), C2(3), C3(7), C5(2), C6(14), C8A(6), C9(11), MASP1(5), MASP2(2), MBL2(1)	6859695	56	39	55	31	6	19	14	7	10	0	1.00	1.00	1.00
479	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(5), FOS(1), GRB2(4), HRAS(1), IL3(1), IL3RA(5), JAK2(4), MAP2K1(6), MAPK3(1), PTPN6(3), RAF1(3), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4)	6077431	55	39	55	19	7	12	15	14	7	0	0.66	1.00	1.00
480	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(1), CD3D(2), CD4(3), ITGAL(20), ITGB2(2), PTPRC(21), THY1(1)	3887962	53	39	53	21	8	19	10	6	10	0	0.89	1.00	1.00
481	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	CHRNB1(4), CHRNG(1), MUSK(9), PIK3CA(11), PIK3R1(3), PTK2(11), PTK2B(8), RAPSN(1), SRC(2), TERT(4)	5591493	54	38	51	16	12	13	14	10	5	0	0.38	1.00	1.00
482	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), CDC42(2), PAK1(5), PDGFRA(17), PIK3CA(11), PIK3R1(3), WASL(5)	4601984	51	38	48	17	6	12	18	7	8	0	0.85	1.00	1.00
483	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(3), FOS(1), HRAS(1), MAP2K1(6), MAPK3(1), NFKB1(3), NFKBIA(1), PLCB1(18), PRKCA(7), RAF1(3)	5298373	44	38	44	14	9	10	13	5	7	0	0.51	1.00	1.00
484	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(10), CREM(2), FHL5(5), FSHB(1), FSHR(20), GNAS(7), XPO1(3)	3263708	48	38	48	21	4	15	13	9	7	0	0.98	1.00	1.00
485	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(4), PGAP1(4), PIGB(1), PIGC(2), PIGG(7), PIGK(2), PIGL(2), PIGM(5), PIGN(2), PIGO(7), PIGP(1), PIGQ(1), PIGS(1), PIGT(2), PIGV(3), PIGW(1), PIGX(4), PIGZ(1)	8254534	51	38	50	16	9	9	20	10	3	0	0.48	1.00	1.00
486	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(4), CAT(3), EPX(7), LPO(4), MPO(4), MTHFR(1), PRDX6(3), SHMT1(2), SHMT2(2), TPO(16)	3991928	46	38	46	16	6	14	13	7	6	0	0.70	1.00	1.00
487	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3D(2), CXCR3(1), ETV5(8), IFNG(4), IL12A(3), IL12RB1(3), IL12RB2(12), IL18R1(3), JAK2(4), MAP2K6(1), MAPK14(1), MAPK8(3), STAT4(6), TYK2(2)	6409710	54	38	54	21	3	15	16	8	12	0	0.89	1.00	1.00
488	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(4), ADCY1(10), CCNB1(1), CDC25C(3), GNAI1(3), GNAS(7), GNB1(2), GNGT1(2), HRAS(1), MAPK3(1), MYT1(6), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RPS6KA1(1), SRC(2)	7030758	55	38	55	23	7	13	14	8	13	0	0.94	1.00	1.00
489	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(7), CHUK(3), IKBKB(3), LTA(2), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAPK14(1), MAPK8(3), NFKB1(3), NFKBIA(1), RIPK1(4), TANK(2), TRAF2(1)	8338119	45	38	45	20	5	15	9	4	12	0	0.96	1.00	1.00
490	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(10), GNAS(7), GNB1(2), GNGT1(2), PPP2CA(1), PRKAA1(4), PRKAB1(3), PRKACB(3), PRKACG(1), PRKAG2(4), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1)	5262878	45	37	45	18	5	14	13	5	8	0	0.91	1.00	1.00
491	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	10	C1QA(1), C1QB(2), C1R(1), C1S(1), C2(3), C3(7), C5(2), C6(14), C8A(6), C9(11)	5537449	48	37	47	26	6	14	12	7	9	0	1.00	1.00	1.00
492	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(3), DHCR24(2), DHCR7(2), EBP(2), FDFT1(2), FDPS(1), GGCX(4), GGPS1(1), HMGCR(4), HSD17B7(1), IDI1(1), LSS(3), MVD(2), MVK(1), NQO1(3), NSDHL(3), PMVK(1), SC4MOL(2), SC5DL(3), SQLE(1), TM7SF2(5), VKORC1(1)	6685197	51	37	50	20	5	18	15	9	4	0	0.86	1.00	1.00
493	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	17	CABIN1(5), CALM1(2), CAPN2(3), CAPNS2(2), EP300(2), HDAC1(3), HDAC2(8), MEF2D(1), NFATC1(3), NFATC2(8), PPP3CB(1), PPP3CC(2), PRKCA(7), SYT1(3)	7993932	50	37	50	18	8	18	14	3	7	0	0.72	1.00	1.00
494	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	18	AMPH(10), AP2A1(2), AP2M1(5), BIN1(1), CALM1(2), DNM1(5), EPN1(5), EPS15(3), PICALM(4), PPP3CB(1), PPP3CC(2), SYNJ1(4), SYNJ2(3), SYT1(3)	7078619	50	37	50	18	5	20	11	7	7	0	0.91	1.00	1.00
495	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(14), CD38(3), ENPP1(6), ENPP3(12), NADSYN1(1), NMNAT1(1), NMNAT2(3), NNMT(5), NNT(4), NT5E(2), NT5M(1), QPRT(2)	5010520	54	37	54	20	7	21	11	10	5	0	0.85	1.00	1.00
496	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(1), CD3D(2), CD8A(2), ITGAL(20), ITGB2(2), PTPRC(21), THY1(1)	3704762	52	37	52	21	8	18	10	6	10	0	0.89	1.00	1.00
497	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(3), CPS1(39), GLS(3), GLUD1(3), GOT1(2)	2677697	51	37	50	17	6	11	15	11	8	0	0.80	1.00	1.00
498	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(3), GCK(4), GFPT1(4), GNE(1), GNPDA1(1), GNPDA2(2), HEXA(1), HK1(3), HK2(9), HK3(12), PGM3(4), RENBP(3), UAP1(6)	5809272	53	36	53	15	13	14	11	9	6	0	0.42	1.00	1.00
499	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(5), CYP11A1(1), CYP11B1(10), CYP11B2(7), CYP17A1(3), CYP21A2(1), HSD11B1(4), HSD11B2(1), HSD3B1(7), HSD3B2(13)	3251113	53	36	53	21	5	22	13	7	6	0	0.86	1.00	1.00
500	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(5), CYP11A1(1), CYP11B1(10), CYP11B2(7), CYP17A1(3), CYP21A2(1), HSD11B1(4), HSD11B2(1), HSD3B1(7), HSD3B2(13)	3251113	53	36	53	21	5	22	13	7	6	0	0.86	1.00	1.00
501	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	16	ABCC1(6), ABCC2(5), ABCG2(5), CES1(3), CES2(1), CYP3A4(1), CYP3A5(1), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5)	7403341	52	36	51	30	11	22	8	8	3	0	0.99	1.00	1.00
502	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(10), ADRB2(2), GNAS(7), PLCE1(14), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RAP2B(1)	5052427	46	36	46	19	3	17	12	5	9	0	0.93	1.00	1.00
503	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	CASP9(3), CDC42(2), CHUK(3), ELK1(2), H2AFX(1), HRAS(1), MAP2K1(6), MAPK3(1), NFKB1(3), PIK3CA(11), PIK3R1(3), RAF1(3), RALA(2), RALBP1(1), RHOA(1)	6558789	43	36	40	15	7	9	11	9	7	0	0.70	1.00	1.00
504	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(8), JAK2(4), JAK3(5), PIAS1(2), PIAS3(6), PTPRU(10), REG1A(9), SOAT1(7)	4808771	51	36	50	16	6	18	9	10	7	1	0.74	1.00	1.00
505	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(6), HLA-DRA(3), IFNG(4), IFNGR1(3), IFNGR2(3), IL12A(3), IL12RB1(3), IL12RB2(12), IL18R1(3), IL2(5), IL2RA(3), IL4(1), IL4R(5)	4359702	55	36	53	19	8	12	17	8	10	0	0.66	1.00	1.00
506	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(7), AGT(2), AGTR2(2), EDN1(1), EDNRB(6), EGF(9), FOS(1), HRAS(1), NFKB1(3), PLCG1(5), PRKCA(7)	6107201	44	35	44	16	9	12	12	7	4	0	0.78	1.00	1.00
507	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	GRB2(4), IL2RG(3), IL4(1), IL4R(5), IRS1(15), JAK1(8), JAK3(5), RPS6KB1(2), SHC1(2), STAT6(2)	5098914	47	35	47	20	10	10	13	12	2	0	0.87	1.00	1.00
508	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(10), CD44(2), CSF1(1), FCGR3A(7), IL6R(8), SELL(4), SPN(3), TGFB1(2), TGFB2(8), TNFRSF1B(1), TNFRSF8(2), TNFSF8(1)	4599007	49	35	49	15	7	15	11	9	7	0	0.58	1.00	1.00
509	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(2), BIRC3(3), CASP3(4), CASP8(4), CFLAR(1), FADD(1), MAP2K4(3), MAP3K3(4), MAP3K7(5), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NR2C2(2), RALBP1(1), RIPK1(4), TNFRSF1B(1), TRAF2(1)	9372512	48	35	48	19	10	9	14	5	10	0	0.82	1.00	1.00
510	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(2), ANXA1(2), CALM1(2), GNAS(7), GNB1(2), GNGT1(2), NFKB1(3), NOS3(2), NPPA(1), NR3C1(3), PIK3CA(11), PIK3R1(3), SYT1(3)	6143154	43	34	40	18	4	12	15	4	8	0	0.92	1.00	1.00
511	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), LCMT1(2), LCMT2(4), METTL2B(5), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), WBSCR22(1)	4817931	44	34	44	14	10	8	19	4	3	0	0.45	1.00	1.00
512	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ITGAL(20), ITGAM(14), ITGB2(2), SELE(6), SELL(4)	3617742	48	34	48	21	8	16	14	5	5	0	0.91	1.00	1.00
513	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), G6PD(2), GPI(3), H6PD(3), PFKM(5), PFKP(3), PGD(2), PGM1(2), PGM3(4), PRPS1(3), PRPS1L1(3), PRPS2(2), RPE(2), RPIA(5), TAL1(3), TKT(1)	7050223	51	34	50	18	12	11	12	12	4	0	0.69	1.00	1.00
514	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(4), CNR2(1), DNMT1(5), MTNR1A(5), MTNR1B(6), PTAFR(2), PTGDR(3), PTGER2(2), PTGER4(7), PTGFR(6), PTGIR(2)	3896206	43	34	43	18	7	13	12	8	3	0	0.77	1.00	1.00
515	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(4), ACO2(1), CS(1), DLD(6), DLST(2), FH(7), IDH1(2), IDH2(2), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(2), MDH2(2), PC(1), SDHA(5), SDHB(1), SUCLG1(2), SUCLG2(2)	6599093	45	33	45	21	9	9	10	8	9	0	0.93	1.00	1.00
516	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(4), G6PD(2), GCLC(8), GCLM(1), GGT1(1), GPX1(1), GPX3(1), GPX5(4), GSS(3), GSTA1(1), GSTA2(3), GSTA3(2), GSTA4(1), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(1), IDH1(2), IDH2(2), MGST1(1), MGST3(3), PGD(2)	6155749	53	33	53	13	6	17	19	4	6	1	0.24	1.00	1.00
517	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(5), AMT(2), ATIC(3), FTCD(3), GART(4), MTFMT(1), MTHFD1(1), MTHFD1L(5), MTHFD2(1), MTHFR(1), MTR(11), SHMT1(2), SHMT2(2)	6542530	41	33	41	20	10	14	7	3	6	1	0.97	1.00	1.00
518	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(10), CPT1A(7), LEP(4), LEPR(13), PRKAA1(4), PRKAB1(3), PRKAG2(4)	4972735	45	33	45	13	7	19	7	7	5	0	0.71	1.00	1.00
519	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	CAT(3), GH1(2), GHR(5), HRAS(1), IGF1(5), IGF1R(10), PIK3CA(11), PIK3R1(3), SHC1(2), SOD2(1), SOD3(1)	4524353	44	33	41	16	4	15	11	6	8	0	0.84	1.00	1.00
520	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(3), ACSL1(8), ACSL3(3), ACSL4(2), CPT1A(7), CPT2(2), DCI(2), EHHADH(8), HADHA(3), PECR(1), SCP2(3), SLC25A20(2)	5754541	44	33	43	15	6	16	6	9	6	1	0.77	1.00	1.00
521	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(2), CD4(3), FYN(3), HLA-DRA(3), LCK(5), PTPRC(21), ZAP70(4)	3126308	41	33	40	13	3	16	10	4	8	0	0.80	1.00	1.00
522	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	6	EPX(7), GBA(3), LPO(4), MPO(4), PRDX6(3), TPO(16)	2570067	37	32	37	15	3	12	12	6	4	0	0.81	1.00	1.00
523	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(8), BCL2(1), CASP3(4), CASP9(3), DAXX(6), FAS(3), FASLG(4), HSPB1(1), HSPB2(1), IL1A(3), MAPKAPK2(3), MAPKAPK3(1)	3892084	42	32	42	16	5	10	8	11	8	0	0.90	1.00	1.00
524	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), BLVRB(1), HMOX1(3), IL10(1), IL10RA(4), IL10RB(2), IL1A(3), JAK1(8), STAT1(4), STAT3(8), STAT5A(3)	4199402	38	32	38	13	1	7	11	11	8	0	0.76	1.00	1.00
525	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(5), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT5(3), DDOST(1), DPAGT1(1), DPM1(1), FUT8(4), MAN1B1(3), MGAT1(2), MGAT3(4), MGAT4A(3), MGAT4B(1), MGAT5(6), RPN2(4)	6863359	42	32	42	11	8	11	11	6	6	0	0.34	1.00	1.00
526	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(3), CD3D(2), CD4(3), CXCR3(1), IFNG(4), IL12A(3), IL12RB1(3), IL12RB2(12), JAK2(4), STAT4(6), TYK2(2)	5062961	44	32	44	18	3	11	13	7	10	0	0.89	1.00	1.00
527	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(8), CHKA(1), PCYT1A(2), PDHA1(3), PDHA2(13), SLC18A3(8)	2406790	38	31	38	13	8	8	11	6	5	0	0.56	1.00	1.00
528	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ACTA1(4), ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), NCK1(3), NCKAP1(4), PIR(2), PSMA7(1), WASF1(8), WASF2(1), WASF3(4), WASL(5)	4779688	40	31	40	12	1	11	11	6	11	0	0.83	1.00	1.00
529	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	5	C3(7), C5(2), C6(14), C8A(6), C9(11)	3812163	40	31	39	17	6	14	9	3	8	0	0.97	1.00	1.00
530	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), BCL2(1), CASP8(4), FADD(1), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), NFKB1(3), NSMAF(2), RAF1(3), RIPK1(4), SMPD1(2), TRAF2(1)	7064879	39	31	39	14	8	6	14	5	6	0	0.64	1.00	1.00
531	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(10), ADRB2(2), CFTR(6), GNAS(7), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), SLC9A3R1(1)	4478782	38	31	38	16	3	12	12	5	6	0	0.90	1.00	1.00
532	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	GRB2(4), HRAS(1), MAPK3(1), MAPK7(5), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), PIK3CA(11), PIK3R1(3), PLCG1(5), RPS6KA1(1), SHC1(2)	6063462	39	31	36	14	6	7	15	8	3	0	0.70	1.00	1.00
533	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(6), IL13(1), IL4(1), MAF(1), MAP2K3(6), MAPK14(1), NFATC1(3), NFATC2(8), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1)	4203753	39	31	38	13	4	16	8	2	9	0	0.62	1.00	1.00
534	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	CASP9(3), CHUK(3), GH1(2), GHR(5), NFKB1(3), NFKBIA(1), PDPK1(1), PIK3CA(11), PIK3R1(3), PPP2CA(1)	4800756	33	30	30	17	2	8	12	4	7	0	0.99	1.00	1.00
535	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(4), ENO1(3), GPI(3), HK1(3), PFKL(2), PGAM1(1), PGK1(5), PKLR(11), TPI1(6)	3205771	38	30	37	15	5	13	11	4	5	0	0.77	1.00	1.00
536	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(1), CARS2(1), CTH(1), GOT1(2), GOT2(4), LDHA(3), LDHAL6A(3), LDHB(2), LDHC(5), SDS(2), SULT1B1(8), SULT1C2(2), SULT1C4(1), SULT4A1(3)	4337260	38	30	38	17	6	15	8	7	2	0	0.96	1.00	1.00
537	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(3), B3GNT2(1), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), CHST1(10), CHST2(4), CHST6(3), FUT8(4), ST3GAL1(3), ST3GAL2(3), ST3GAL3(1), ST3GAL4(2)	4290773	39	30	38	22	12	6	12	4	5	0	0.97	1.00	1.00
538	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	GOSR2(1), SEC22B(5), SNAP23(1), SNAP25(4), STX11(1), STX12(2), STX16(3), STX17(1), STX18(2), STX19(3), STX2(8), STX3(3), STX7(2), STX8(3), TSNARE1(1), VTI1A(1)	5810875	41	30	40	18	7	9	8	8	9	0	0.96	1.00	1.00
539	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(5), AMT(2), ATIC(3), GART(4), MTHFD1(1), MTHFD1L(5), MTHFD2(1), MTHFR(1), MTR(11), SHMT1(2), SHMT2(2)	6166512	37	30	37	18	9	13	5	3	6	1	0.96	1.00	1.00
540	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(3), IKBKAP(5), IKBKB(3), LTA(2), MAP3K1(4), MAP3K14(1), NFKB1(3), NFKBIA(1), RIPK1(4), TANK(2), TNFRSF1B(1), TRAF2(1), TRAF3(3)	7701270	33	30	33	17	2	7	13	4	7	0	0.98	1.00	1.00
541	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(2), CCL4(1), CCR5(1), CXCL12(1), CXCR4(3), FOS(1), GNAQ(2), MAPK14(1), MAPK8(3), PLCG1(5), PRKCA(7), PTK2B(8), SYT1(3)	4713049	38	29	38	17	10	12	10	1	5	0	0.84	1.00	1.00
542	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(3), DHCR7(2), FDFT1(2), FDPS(1), HMGCR(4), HMGCS1(5), IDI1(1), LSS(3), MVD(2), MVK(1), NSDHL(3), PMVK(1), SC4MOL(2), SC5DL(3), SQLE(1)	4565802	34	29	33	13	2	13	10	7	1	1	0.85	1.00	1.00
543	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(8), ARHGAP5(7), CASP1(2), CASP10(6), CASP3(4), CASP8(4), CASP9(3), GZMB(3), PRF1(5)	4422677	42	29	42	12	5	11	9	11	6	0	0.63	1.00	1.00
544	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	15	LCMT1(2), LCMT2(4), METTL2B(5), METTL6(1), PCYT1A(2), PCYT1B(3), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), WBSCR22(1)	4510613	41	29	41	13	10	7	18	3	3	0	0.49	1.00	1.00
545	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(2), B3GNT1(3), B3GNT2(1), B3GNT3(1), B3GNT5(1), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), FUT1(2), FUT3(2), FUT7(2), FUT9(7), GCNT2(2), ST3GAL6(3), ST8SIA1(2)	5541571	33	29	32	19	7	6	10	6	4	0	0.98	1.00	1.00
546	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(2), NFKB1(3), NFKBIA(1), PLCB1(18), PRKCA(7)	2821738	31	29	31	11	6	10	9	0	6	0	0.77	1.00	1.00
547	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(10), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLRMT(1)	4631296	39	29	38	16	8	8	13	6	4	0	0.85	1.00	1.00
548	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNAQ(2), GNB1(2), GNGT1(2), HTR2C(6), PLCB1(18), TUB(3)	2457628	35	29	35	10	5	15	9	0	6	0	0.55	1.00	1.00
549	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(8), UBE2A(4), UBE2D2(1), UBE2D3(4), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(1), UBE2J1(3), UBE2J2(2), UBE2L6(1), UBE2M(1), UBE2N(1), UBE3A(8)	3617742	38	29	37	14	9	11	4	7	7	0	0.80	1.00	1.00
550	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(4), CYP2A6(4), CYP2A7(4), NAT1(3), NAT2(2), XDH(11)	2737695	30	28	30	10	1	11	9	3	6	0	0.51	1.00	1.00
551	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	5	ADAM17(7), ERBB4(21), NRG2(2), PRKCA(7), PSEN1(1)	2639683	38	27	38	12	5	16	11	3	3	0	0.74	1.00	1.00
552	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(4), HK1(3), HK2(9), HK3(12), IMPA1(1), IMPA2(1), ISYNA1(2), PGM1(2), PGM3(4), TGDS(2)	4028339	40	27	40	16	12	10	9	7	2	0	0.73	1.00	1.00
553	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(8), BAX(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), DFFA(3), DFFB(2)	4694500	34	27	34	13	4	8	9	5	8	0	0.89	1.00	1.00
554	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), HDAC9(20), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), MYOD1(5)	2782808	33	27	33	12	3	13	6	5	6	0	0.85	1.00	1.00
555	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	22	CALM1(2), CAMK1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), HDAC5(2), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), PPARA(1), PPP3CB(1), PPP3CC(2), SYT1(3)	6665045	35	27	35	17	3	13	8	6	5	0	0.96	1.00	1.00
556	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), CD3D(2), GZMB(3), HLA-A(2), ITGAL(20), ITGB2(2), PRF1(5)	3004022	35	26	35	15	5	8	10	6	6	0	0.83	1.00	1.00
557	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(2), FOS(1), MAPK3(1), OPRK1(5), POLR2A(9), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1)	4408021	30	26	30	10	6	9	9	3	3	0	0.59	1.00	1.00
558	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(5), CYP11A1(1), CYP11B2(7), CYP17A1(3), HSD11B1(4), HSD11B2(1), HSD3B1(7), HSD3B2(13)	2393737	41	26	41	15	7	17	8	6	3	0	0.69	1.00	1.00
559	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	MRPL13(1), MRPS7(2), RPL11(1), RPL12(1), RPL14(1), RPL19(2), RPL21(1), RPL23A(2), RPL24(1), RPL27A(1), RPL29(1), RPL3(1), RPL30(3), RPL35(1), RPL36A(1), RPL37(1), RPL3L(2), RPL6(3), RPL7(1), RPL8(1), RPS10(1), RPS11(1), RPS12(1), RPS13(2), RPS18(1), RPS26(1), RPS29(1), RPS4Y1(1), RPSA(1)	7817602	38	26	38	14	9	11	8	5	5	0	0.77	1.00	1.00
560	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), FDXR(2), SHMT1(2)	5516610	37	26	36	13	10	7	9	7	4	0	0.68	1.00	1.00
561	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(8), BAX(1), BCL10(1), BCL2(1), BCL2L11(2), BID(1), CASP8AP2(10), CASP9(3), CES1(3)	3918877	30	26	30	15	4	10	8	5	3	0	0.98	1.00	1.00
562	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(8), JAK2(4), JAK3(5), MAPK3(1), STAT3(8), TYK2(2)	4066582	28	26	28	13	3	5	7	9	4	0	0.94	1.00	1.00
563	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(2), HS3ST2(2), HS3ST3A1(4), HS3ST3B1(1), XYLT1(19)	2303740	29	25	29	12	7	3	13	4	2	0	0.62	1.00	1.00
564	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	CCL3(1), EPO(3), FLT3(10), IGF1(5), IL1A(3), IL3(1), TGFB1(2), TGFB2(8), TGFB3(1)	2810059	34	25	34	12	4	12	4	8	6	0	0.76	1.00	1.00
565	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(2), HS3ST2(2), HS3ST3A1(4), HS3ST3B1(1), XYLT1(19)	2303740	29	25	29	12	7	3	13	4	2	0	0.62	1.00	1.00
566	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(3), ACOX3(6), FADS2(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1)	3505761	38	25	38	15	10	13	6	7	2	0	0.86	1.00	1.00
567	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(4), ACO2(1), AFMID(2), CS(1), GRHPR(1), HAO1(4), HAO2(8), MDH1(2), MDH2(2), MTHFD1(1), MTHFD1L(5), MTHFD2(1)	4599007	32	25	32	11	6	12	5	3	6	0	0.72	1.00	1.00
568	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(7), ESCO2(2), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), SH3GLB1(1)	5698207	37	25	37	12	5	13	6	8	5	0	0.72	1.00	1.00
569	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL1(3), FOSL2(1), IFNAR2(2), IFNB1(4), MAPK8(3), NFKB1(3), TNFRSF11A(7), TNFSF11(1), TRAF6(4)	3820407	29	25	28	11	6	6	6	4	7	0	0.84	1.00	1.00
570	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(4), HK1(3), HK2(9), HK3(12), IMPA1(1), PGM1(2), PGM3(4), TGDS(2)	3534386	37	25	37	15	10	10	9	6	2	0	0.78	1.00	1.00
571	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(2), ARFGAP3(2), ARFGEF2(6), CLTB(1), COPA(10), GBF1(7), GPLD1(4), KDELR1(1), KDELR2(1), KDELR3(5)	5529892	39	24	39	10	6	16	7	5	5	0	0.49	1.00	1.00
572	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), SHMT1(2)	5182499	35	24	34	13	10	7	7	7	4	0	0.76	1.00	1.00
573	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	12	CREBBP(4), EP300(2), NCOA3(8), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RARA(3), RXRA(1)	6769240	30	24	30	13	4	11	8	3	4	0	0.91	1.00	1.00
574	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), SHMT1(2)	5182499	35	24	34	13	10	7	7	7	4	0	0.76	1.00	1.00
575	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	5	ACACA(10), ACACB(11), FASN(4), MCAT(1), OXSM(5)	5301121	31	24	31	20	6	11	10	2	2	0	0.99	1.00	1.00
576	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(1), B3GALT5(1), FUT1(2), FUT9(7), GLA(4), HEXA(1), NAGA(3), ST3GAL1(3), ST3GAL2(3), ST8SIA1(2)	3668122	27	24	27	14	7	2	11	6	1	0	0.93	1.00	1.00
577	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), SHMT1(2)	5182499	35	24	34	13	10	7	7	7	4	0	0.76	1.00	1.00
578	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(3), NDUFB2(4), NDUFB4(1), NDUFB5(4), NDUFB6(1), NDUFS1(7), NDUFS2(6), NDUFV1(3)	2394195	33	24	33	13	4	8	8	5	8	0	0.86	1.00	1.00
579	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(7), GNB1(2), GNGT1(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7)	3291875	32	23	32	12	7	10	10	1	4	0	0.84	1.00	1.00
580	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(2), CAMK1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), CAMKK1(2), CAMKK2(1), SYT1(3)	3999256	26	23	26	10	2	12	3	5	4	0	0.82	1.00	1.00
581	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(2), FUT9(7), GLA(4), HEXA(1), NAGA(3), ST3GAL1(3), ST3GAL2(3), ST3GAL4(2), ST8SIA1(2)	3455839	27	23	27	13	7	2	10	6	2	0	0.89	1.00	1.00
582	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), CYSLTR2(4), GPR109B(1), GPR171(1), GPR18(2), GPR34(3), GPR39(2), GPR45(3), GPR65(8), GPR75(2)	3348438	27	23	26	13	1	6	10	7	3	0	0.92	1.00	1.00
583	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(3), CHST11(1), CHST12(5), CHST13(3), PAPSS1(3), PAPSS2(4), SULT1A2(1), SULT1E1(1), SULT2A1(3), SULT2B1(1), SUOX(5)	3174169	30	23	29	10	2	9	10	7	2	0	0.68	1.00	1.00
584	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(2), CRY1(3), CRY2(2), CSNK1D(2), CSNK1E(6), NPAS2(1), NR1D1(3), PER1(3), PER2(4), PER3(1)	5916673	29	23	29	12	8	9	9	0	3	0	0.83	1.00	1.00
585	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(4), EP300(2), LPL(5), NCOA1(5), NCOA2(6), PPARG(3), RXRA(1)	6362994	26	23	26	15	3	10	6	4	3	0	0.99	1.00	1.00
586	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(3), CREBBP(4), EP300(2), FADD(1), HDAC3(1), IKBKB(3), NFKB1(3), NFKBIA(1), RIPK1(4), TNFRSF1B(1), TRAF6(4)	7715697	27	23	26	17	5	4	7	3	8	0	0.99	1.00	1.00
587	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(10), AGT(2), AGTR1(5), AGTR2(2), BDKRB2(1), KNG1(3), NOS3(2), REN(1)	3453091	26	22	26	17	2	10	10	2	2	0	0.99	1.00	1.00
588	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDFT1(2), FDPS(1), HMGCR(4), IDI1(1), LSS(3), MVD(2), MVK(1), NQO1(3), NQO2(2), PMVK(1), SC5DL(3), SQLE(1), VKORC1(1)	3835979	27	22	26	13	3	10	7	5	2	0	0.93	1.00	1.00
589	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(3), IKBKAP(5), IKBKB(3), MAP3K1(4), MAP3K14(1), NFKB1(3), NFKBIA(1), TRAF3(3), TRAF6(4)	6216892	27	22	26	16	4	3	11	2	7	0	0.99	1.00	1.00
590	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	EHHADH(8), HADH(4), HADHA(3), HSD17B4(5), SIRT1(1), SIRT2(2), SIRT7(3), VNN2(4)	4077574	30	22	28	10	1	12	6	3	7	1	0.83	1.00	1.00
591	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(2), CTSD(2), ESR1(1), GREB1(14), HSPB1(1), HSPB2(1), MTA1(1), MTA3(3), PDZK1(2), TUBA8(1)	3783767	28	22	28	11	6	7	11	3	1	0	0.63	1.00	1.00
592	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(10), AOC2(4), AOC3(5), CES1(3), ESD(1)	2085274	23	21	23	10	3	9	6	2	3	0	0.86	1.00	1.00
593	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(9), ALDH2(2), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), UGDH(4)	2946314	25	20	25	11	3	7	8	4	3	0	0.85	1.00	1.00
594	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(10), GNAS(7), GNB1(2), GNGT1(2), PRKAR1A(1)	2243513	22	19	22	13	2	6	7	3	4	0	0.98	1.00	1.00
595	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(3), ACOX3(6), ELOVL2(4), ELOVL6(1), FADS2(1), FASN(4), HADHA(3), HSD17B12(1), PECR(1)	4953499	24	19	24	13	4	6	8	4	1	1	0.91	1.00	1.00
596	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(5), CAPNS2(2), CDK5(1), CSNK1A1(1), CSNK1D(2), GSK3B(2), MAPT(8), PPP2CA(1)	3277448	22	18	22	12	4	9	5	3	1	0	0.95	1.00	1.00
597	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(4), CKM(1), EIF4E(3), LDHA(3), LDHB(2), LDHC(5), MAPK14(1), NCL(4)	3040891	23	18	23	10	4	5	7	3	4	0	0.87	1.00	1.00
598	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25A(4), CDC25B(1), CDC25C(3), GRB2(4), PRKCA(7), PTPRA(4), SRC(2)	3158597	26	18	26	10	6	10	5	4	1	0	0.77	1.00	1.00
599	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(3), MAP3K14(1), MAPK14(1), MAPK8(3), NFKB1(3), TNFRSF13B(1), TNFSF13B(1), TRAF2(1), TRAF3(3), TRAF5(2), TRAF6(4)	5003421	23	18	22	15	5	2	8	2	6	0	0.99	1.00	1.00
600	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGF(9), ERBB3(3), NRG1(9)	2627317	21	17	20	10	5	3	6	1	6	0	0.90	1.00	1.00
601	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSR(1), GSS(3), NFKB1(3), NOX1(3), XDH(11)	3426069	22	17	22	10	3	7	8	2	2	0	0.84	1.00	1.00
602	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(2), COPS5(1), EDN1(1), EP300(2), EPO(3), HIF1A(1), LDHA(3), NOS3(2), P4HB(4), VHL(1)	5899498	22	17	22	15	2	8	4	2	5	1	1.00	1.00	1.00
603	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(2), FARSB(3), GOT1(2), GOT2(4), PAH(3), TAT(4), YARS(1), YARS2(2)	2995549	22	17	22	10	6	9	5	1	1	0	0.85	1.00	1.00
604	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(9), APOBEC1(1), APOBEC3B(4), APOBEC3F(1), APOBEC3G(3), APOBEC4(1)	2524038	19	17	19	10	5	7	4	1	2	0	0.95	1.00	1.00
605	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(1), EPO(3), EPOR(1), GRIN1(2), HIF1A(1), JAK2(4), NFKB1(3), NFKBIA(1), SOD2(1)	4383747	19	16	19	14	2	7	4	2	4	0	1.00	1.00	1.00
606	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(4), NR1I3(5), PTGS1(5), PTGS2(4)	1823069	20	15	20	10	5	4	6	3	2	0	0.89	1.00	1.00
607	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(1), CTH(1), GOT1(2), GOT2(4), LDHA(3), LDHB(2), LDHC(5)	2352288	18	15	18	11	5	4	5	2	2	0	0.97	1.00	1.00
608	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), CS(1), FH(7), IDH2(2), MDH1(2), OGDH(1), SDHA(5)	3216534	19	14	19	14	5	4	5	3	2	0	0.98	1.00	1.00
609	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO3(2), FARS2(1), GOT1(2), GOT2(4), PAH(3), TAT(4), YARS(1)	2843951	20	14	20	10	5	9	4	2	0	0	0.89	1.00	1.00
610	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(3), GPD2(4), SDHA(5), SDHB(1), SDHD(1)	2269619	14	12	14	14	2	1	9	1	1	0	1.00	1.00	1.00
611	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA2B(1), ADORA3(2), LTB4R(2), P2RY1(5), P2RY6(1)	2030772	12	11	12	11	2	1	5	2	2	0	0.98	1.00	1.00
612	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(4), EP300(2), ESR1(1), MAPK3(1), PELP1(2), SRC(2)	5057923	12	10	12	6	4	1	5	0	2	0	0.78	1.00	1.00
613	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	5	ASRGL1(1), GBA(3), GGT1(1), SHMT1(2), SHMT2(2)	1626358	9	8	9	7	3	2	4	0	0	0	0.93	1.00	1.00
614	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(3)	628834	5	5	5	4	0	1	0	4	0	0	0.96	1.00	1.00
615	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	248236	1	1	1	3	1	0	0	0	0	0	1.00	1.00	1.00
616	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1)	718144	1	1	1	2	0	0	0	1	0	0	0.99	1.00	1.00
