E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.028 0.144 -9999.0 0.0 -0.451 10.0 10.0 KLHL20 -0.01 0.112 0.189 1.0 -0.329 9.0 10.0 CYFIP2 0.028 0.048 -9999.0 0.0 -0.509 1.0 1.0 Rac1/GDP 0.003 0.11 0.248 1.0 -0.342 2.0 3.0 ENAH -0.029 0.148 -9999.0 0.0 -0.451 10.0 10.0 AP1M1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.062 -9999.0 0.0 -0.509 2.0 2.0 CTNNB1 0.031 0.019 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.014 0.078 -9999.0 0.0 -0.291 1.0 1.0 ABI1/Sra1/Nap1 -0.033 0.061 -9999.0 0.0 -0.213 10.0 10.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.059 0.082 -9999.0 0.0 -0.289 6.0 6.0 RAPGEF1 -0.018 0.126 -9999.0 0.0 -0.428 7.0 7.0 CTNND1 0.019 0.097 -9999.0 0.0 -0.509 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.154 -9999.0 0.0 -0.441 12.0 12.0 CRK -0.015 0.134 -9999.0 0.0 -0.461 7.0 7.0 E-cadherin/gamma catenin/alpha catenin 0.022 0.126 -9999.0 0.0 -0.333 16.0 16.0 alphaE/beta7 Integrin 0.05 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.049 -9999.0 0.0 -0.509 1.0 1.0 Rap1/GTP/I-afadin 0.057 0.047 -9999.0 0.0 -0.288 2.0 2.0 DLG1 -0.03 0.148 -9999.0 0.0 -0.451 10.0 10.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.013 0.048 -9999.0 0.0 -0.238 3.0 3.0 MLLT4 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.058 0.047 -9999.0 0.0 -0.288 2.0 2.0 PI3K -0.015 0.063 -9999.0 0.0 -0.312 3.0 3.0 ARF6 0.027 0.063 -9999.0 0.0 -0.509 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.002 0.137 -9999.0 0.0 -0.389 16.0 16.0 TIAM1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.045 0.096 -9999.0 0.0 -0.27 11.0 11.0 AKT1 0.032 0.07 0.162 3.0 -0.221 3.0 6.0 PIK3R1 0.01 0.092 -9999.0 0.0 -0.509 4.0 4.0 CDH1 0.012 0.106 -9999.0 0.0 -0.509 6.0 6.0 RhoA/GDP 0.008 0.107 0.251 1.0 -0.367 1.0 2.0 actin cytoskeleton organization -0.004 0.083 0.148 3.0 -0.239 8.0 11.0 CDC42/GDP 0.006 0.11 0.251 1.0 -0.342 2.0 3.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.016 0.11 -9999.0 0.0 -0.28 20.0 20.0 ITGB7 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.049 0.102 -9999.0 0.0 -0.287 11.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.039 0.069 -9999.0 0.0 -0.269 6.0 6.0 mol:GDP -0.014 0.116 0.249 1.0 -0.375 3.0 4.0 CDC42/GTP/IQGAP1 0.047 0.012 -9999.0 0.0 -9999.0 0.0 0.0 JUP -0.005 0.14 -9999.0 0.0 -0.509 11.0 11.0 p120 catenin/RhoA/GDP 0.012 0.118 0.262 1.0 -0.392 1.0 2.0 RAC1/GTP/IQGAP1 0.047 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.046 0.039 -9999.0 0.0 -0.371 1.0 1.0 RHOA 0.032 0.012 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.035 0.009 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.009 0.077 0.119 1.0 -0.233 12.0 13.0 NME1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.032 0.152 -9999.0 0.0 -0.455 11.0 11.0 regulation of cell-cell adhesion 0.001 0.061 -9999.0 0.0 -0.255 1.0 1.0 WASF2 -0.004 0.047 -9999.0 0.0 -0.179 2.0 2.0 Rap1/GTP 0.014 0.087 -9999.0 0.0 -0.326 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.125 -9999.0 0.0 -0.289 16.0 16.0 CCND1 -0.012 0.095 -9999.0 0.0 -0.293 12.0 12.0 VAV2 -0.048 0.243 -9999.0 0.0 -0.704 14.0 14.0 RAP1/GDP 0.016 0.101 0.267 1.0 -0.355 1.0 2.0 adherens junction assembly -0.031 0.147 -9999.0 0.0 -0.44 11.0 11.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.047 -9999.0 0.0 -0.509 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.028 0.112 -9999.0 0.0 -0.283 14.0 14.0 E-cadherin/beta catenin -0.0 0.075 -9999.0 0.0 -0.336 7.0 7.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.024 0.141 -9999.0 0.0 -0.461 9.0 9.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.509 2.0 2.0 Rac1/GTP -0.068 0.164 -9999.0 0.0 -0.524 13.0 13.0 E-cadherin/beta catenin/alpha catenin 0.044 0.08 -9999.0 0.0 -0.315 6.0 6.0 ITGAE 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.023 0.157 -9999.0 0.0 -0.461 11.0 11.0