Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.141 0.278 -9999.0 0.0 -0.573 43.0 43.0 IHH -0.011 0.091 -9999.0 0.0 -0.275 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.044 0.145 -9999.0 0.0 -0.322 30.0 30.0 LRPAP1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.044 0.144 0.32 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 -0.116 0.234 -9999.0 0.0 -0.422 44.0 44.0 SMO -0.129 0.238 -9999.0 0.0 -0.408 55.0 55.0 AKT1 -0.071 0.222 -9999.0 0.0 -0.681 14.0 14.0 ARRB2 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.023 0.031 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.127 0.234 -9999.0 0.0 -0.402 55.0 55.0 STIL -0.078 0.159 -9999.0 0.0 -0.294 47.0 47.0 DHH N/PTCH2 0.052 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.057 0.154 -9999.0 0.0 -0.296 43.0 43.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.509 2.0 2.0 DHH 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.256 0.455 -9999.0 0.0 -0.988 42.0 42.0 determination of left/right symmetry -0.127 0.234 -9999.0 0.0 -0.402 55.0 55.0 PIK3R1 0.01 0.092 -9999.0 0.0 -0.509 4.0 4.0 skeletal system development -0.252 0.449 -9999.0 0.0 -0.973 42.0 42.0 IHH N/Hhip -0.055 0.159 -9999.0 0.0 -0.411 22.0 22.0 DHH N/Hhip -0.025 0.141 -9999.0 0.0 -0.371 20.0 20.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.127 0.234 -9999.0 0.0 -0.402 55.0 55.0 pancreas development -0.06 0.18 -9999.0 0.0 -0.508 20.0 20.0 HHAT -0.006 0.146 -9999.0 0.0 -0.509 12.0 12.0 PI3K 0.006 0.071 -9999.0 0.0 -0.371 4.0 4.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.055 0.19 -9999.0 0.0 -0.509 22.0 22.0 somite specification -0.127 0.234 -9999.0 0.0 -0.402 55.0 55.0 SHH Np/Cholesterol/PTCH1 -0.078 0.161 -9999.0 0.0 -0.299 48.0 48.0 SHH Np/Cholesterol/PTCH2 0.008 0.09 -9999.0 0.0 -0.287 13.0 13.0 SHH Np/Cholesterol/Megalin 0.001 0.096 -9999.0 0.0 -0.295 14.0 14.0 SHH -0.014 0.108 -9999.0 0.0 -0.371 13.0 13.0 catabolic process -0.081 0.161 -9999.0 0.0 -0.332 43.0 43.0 SMO/Vitamin D3 -0.108 0.203 -9999.0 0.0 -0.377 46.0 46.0 SHH Np/Cholesterol/Hhip -0.047 0.135 -9999.0 0.0 -0.305 30.0 30.0 LRP2 0.022 0.057 -9999.0 0.0 -0.509 1.0 1.0 receptor-mediated endocytosis -0.106 0.197 -9999.0 0.0 -0.368 47.0 47.0 SHH Np/Cholesterol/BOC -0.0 0.087 -9999.0 0.0 -0.287 12.0 12.0 SHH Np/Cholesterol/CDO 0.006 0.091 -9999.0 0.0 -0.289 13.0 13.0 mesenchymal cell differentiation 0.046 0.134 0.304 30.0 -9999.0 0.0 30.0 mol:Vitamin D3 -0.077 0.162 0.208 1.0 -0.299 48.0 49.0 IHH N/PTCH2 0.02 0.063 -9999.0 0.0 -0.326 1.0 1.0 CDON 0.031 0.025 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.066 0.172 -9999.0 0.0 -0.334 43.0 43.0 Megalin/LRPAP1 0.037 0.048 -9999.0 0.0 -0.371 1.0 1.0 PTCH2 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.004 0.086 -9999.0 0.0 -0.285 13.0 13.0 PTCH1 -0.081 0.161 -9999.0 0.0 -0.333 43.0 43.0 HHIP -0.06 0.181 -9999.0 0.0 -0.509 20.0 20.0