Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.003 0.085 -9999.0 0.0 -0.273 11.0 11.0 epithelial cell differentiation 0.04 0.092 -9999.0 0.0 -0.268 11.0 11.0 CYFIP2 0.028 0.048 -9999.0 0.0 -0.509 1.0 1.0 ENAH -0.001 0.117 0.265 5.0 -0.331 5.0 10.0 EGFR -0.03 0.17 -9999.0 0.0 -0.509 17.0 17.0 EPHA2 -0.012 0.147 -9999.0 0.0 -0.509 12.0 12.0 MYO6 -0.007 0.091 -9999.0 0.0 -0.283 13.0 13.0 CTNNB1 0.031 0.019 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.054 0.056 -9999.0 0.0 -0.317 2.0 2.0 AQP5 -0.084 0.188 -9999.0 0.0 -0.504 23.0 23.0 CTNND1 0.019 0.097 -9999.0 0.0 -0.509 5.0 5.0 mol:PI-4-5-P2 -0.006 0.077 -9999.0 0.0 -0.258 11.0 11.0 regulation of calcium-dependent cell-cell adhesion -0.018 0.097 -9999.0 0.0 -0.292 14.0 14.0 EGF -0.033 0.153 -9999.0 0.0 -0.509 13.0 13.0 NCKAP1 0.029 0.049 -9999.0 0.0 -0.509 1.0 1.0 AQP3 -0.116 0.203 -9999.0 0.0 -0.502 30.0 30.0 cortical microtubule organization 0.04 0.092 -9999.0 0.0 -0.268 11.0 11.0 GO:0000145 -0.027 0.067 -9999.0 0.0 -0.247 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.045 0.096 -9999.0 0.0 -0.27 11.0 11.0 MLLT4 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.053 0.105 -9999.0 0.0 -0.487 5.0 5.0 ARF6 0.027 0.063 -9999.0 0.0 -0.509 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.021 0.123 -9999.0 0.0 -0.361 11.0 11.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.013 0.063 -9999.0 0.0 -0.305 3.0 3.0 PVRL2 0.031 0.047 -9999.0 0.0 -0.509 1.0 1.0 ZYX -0.008 0.082 -9999.0 0.0 -0.259 13.0 13.0 ARF6/GTP 0.022 0.129 -9999.0 0.0 -0.361 11.0 11.0 CDH1 0.012 0.106 -9999.0 0.0 -0.509 6.0 6.0 EGFR/EGFR/EGF/EGF -0.039 0.156 -9999.0 0.0 -0.328 29.0 29.0 RhoA/GDP 0.041 0.09 -9999.0 0.0 -0.259 9.0 9.0 actin cytoskeleton organization -0.032 0.095 -9999.0 0.0 -0.33 10.0 10.0 IGF-1R heterotetramer -0.005 0.14 -9999.0 0.0 -0.508 11.0 11.0 GIT1 0.027 0.063 -9999.0 0.0 -0.509 2.0 2.0 IGF1R -0.005 0.14 -9999.0 0.0 -0.509 11.0 11.0 IGF1 -0.048 0.183 -9999.0 0.0 -0.509 20.0 20.0 DIAPH1 0.01 0.192 -9999.0 0.0 -0.693 4.0 4.0 Wnt receptor signaling pathway -0.04 0.092 0.268 11.0 -9999.0 0.0 11.0 RHOA 0.032 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.051 0.097 -9999.0 0.0 -0.442 5.0 5.0 CTNNA1 0.035 0.009 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.033 0.098 -9999.0 0.0 -0.338 10.0 10.0 EFNA1 0.022 0.077 -9999.0 0.0 -0.509 3.0 3.0 LPP -0.021 0.059 -9999.0 0.0 -0.268 3.0 3.0 Ephrin A1/EPHA2 0.001 0.132 -9999.0 0.0 -0.315 18.0 18.0 SEC6/SEC8 -0.005 0.071 -9999.0 0.0 -0.303 1.0 1.0 MGAT3 -0.019 0.099 -9999.0 0.0 -0.297 14.0 14.0 HGF/MET 0.026 0.092 -9999.0 0.0 -0.259 3.0 3.0 HGF 0.032 0.023 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.003 0.086 -9999.0 0.0 -0.275 11.0 11.0 actin cable formation 0.047 0.128 0.269 11.0 -0.339 3.0 14.0 KIAA1543 -0.031 0.076 -9999.0 0.0 -0.271 3.0 3.0 KIFC3 -0.002 0.076 -9999.0 0.0 -0.262 9.0 9.0 NCK1 0.025 0.046 -9999.0 0.0 -0.509 1.0 1.0 EXOC3 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.003 0.077 -9999.0 0.0 -0.265 10.0 10.0 NCK1/GIT1 0.03 0.062 -9999.0 0.0 -0.371 3.0 3.0 mol:GDP 0.04 0.092 -9999.0 0.0 -0.268 11.0 11.0 EXOC4 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.028 0.064 -9999.0 0.0 -0.257 11.0 11.0 PIP5K1C -0.006 0.078 -9999.0 0.0 -0.261 11.0 11.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.0 0.134 0.296 5.0 -0.389 5.0 10.0 adherens junction assembly -0.027 0.117 0.254 1.0 -0.554 3.0 4.0 IGF-1R heterotetramer/IGF1 -0.035 0.148 -9999.0 0.0 -0.291 31.0 31.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.047 0.039 -9999.0 0.0 -0.371 1.0 1.0 MET 0.023 0.077 -9999.0 0.0 -0.509 3.0 3.0 PLEKHA7 -0.001 0.078 -9999.0 0.0 -0.261 10.0 10.0 mol:GTP 0.019 0.121 -9999.0 0.0 -0.359 11.0 11.0 establishment of epithelial cell apical/basal polarity -0.03 0.066 -9999.0 0.0 -0.293 1.0 1.0 cortical actin cytoskeleton stabilization -0.003 0.085 -9999.0 0.0 -0.273 11.0 11.0 regulation of cell-cell adhesion -0.032 0.095 -9999.0 0.0 -0.33 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.003 0.086 -9999.0 0.0 -0.275 11.0 11.0