rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	232	ACVR1B(1), ACVR1C(2), BRAF(2), CACNA1A(5), CACNA1B(1), CACNA1C(9), CACNA1D(6), CACNA1E(4), CACNA1F(4), CACNA1G(3), CACNA1S(5), CACNA2D1(4), CACNA2D2(1), CACNA2D3(1), CACNA2D4(1), CACNB1(1), CACNB2(1), CACNB4(1), CACNG3(1), CACNG6(2), CDC25B(2), CHUK(1), DAXX(1), DDIT3(2), DUSP1(2), DUSP7(1), DUSP9(2), ECSIT(1), EGFR(7), ELK1(2), FGF12(1), FGF2(1), FGF23(2), FGF5(1), FGF6(1), FGFR4(1), FLNA(1), FLNB(3), FLNC(3), FOS(1), GADD45A(1), GADD45B(1), GNA12(1), GRB2(2), IKBKB(1), KRAS(2), MAP2K3(1), MAP2K4(1), MAP2K6(1), MAP3K1(1), MAP3K10(2), MAP3K12(1), MAP3K13(2), MAP3K14(1), MAP3K2(2), MAP3K3(1), MAP3K4(2), MAP3K5(2), MAP3K6(1), MAP3K7(3), MAP4K1(1), MAP4K3(3), MAPK14(1), MAPK8(1), MAPK8IP1(1), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MEF2C(1), MKNK1(1), MOS(1), MRAS(1), NF1(15), NFATC2(1), NFATC4(1), NFKB1(1), NLK(1), NRAS(2), NTF3(1), NTRK1(4), NTRK2(1), PAK2(1), PDGFRA(3), PDGFRB(3), PLA2G12A(1), PLA2G12B(1), PLA2G2F(1), PLA2G4A(1), PLA2G6(1), PPP3CC(1), PPP5C(1), PRKACG(1), PRKCA(1), PRKCG(1), PTPN5(3), PTPRR(1), RAPGEF2(1), RASA1(1), RASA2(2), RASGRF1(2), RASGRF2(4), RASGRP1(1), RASGRP2(1), RASGRP3(2), RPS6KA1(1), RPS6KA2(1), RPS6KA4(1), RPS6KA5(1), RRAS(1), SOS1(3), SOS2(1), SRF(1), STK4(1), TAOK1(1), TAOK3(1), TGFBR2(3), TNF(1), TNFRSF1A(1), TP53(279), TRAF2(1), TRAF6(2)	116594517	496	293	358	53	79	59	109	115	134	0	<1.00e-15	<2.93e-14
2	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	106	ABL1(1), ANAPC1(1), ANAPC2(1), ANAPC4(1), ANAPC5(1), ATM(5), ATR(2), BUB1(1), BUB1B(2), BUB3(1), CCNA1(2), CCNA2(1), CCNB3(3), CCNH(1), CDC20(1), CDC25B(2), CDC27(4), CDC6(1), CDC7(2), CDK2(1), CDKN1A(1), CDKN1B(1), CDKN2C(2), CDKN2D(1), CHEK2(1), CREBBP(7), E2F2(1), EP300(1), GADD45A(1), GADD45B(1), GSK3B(1), HDAC1(1), MAD2L2(1), MCM2(2), MCM3(1), MCM4(2), MCM5(2), ORC1L(1), ORC4L(1), PRKDC(8), RB1(9), RBL1(1), RBL2(3), SKP2(2), SMC1A(5), SMC1B(3), TFDP1(2), TP53(279), YWHAB(1), YWHAE(2), YWHAG(2)	59044916	380	287	244	28	60	44	71	84	121	0	<1.00e-15	<2.93e-14
3	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(5), CCNA1(2), CCNG2(1), CCNH(1), CDK2(1), CDKN1A(1), CDKN1B(1), CDKN2C(2), CDKN2D(1), CREB3L1(1), CREB3L4(1), E2F2(1), E2F5(1), GADD45A(1), GBA2(2), MCM2(2), MCM3(1), MCM4(2), MCM5(2), MNAT1(1), MYT1(2), NACA(4), ORC1L(1), ORC4L(1), POLE(2), POLE2(1), RB1(9), RBL1(1), RPA1(2), RPA2(1), TFDP1(2), TNXB(4), TP53(279)	32487850	339	286	203	24	56	38	60	70	115	0	<1.00e-15	<2.93e-14
4	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	138	APC(8), AXIN2(1), BTRC(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CHD8(5), CREBBP(7), CSNK1A1L(1), CSNK1E(1), CSNK2A1(1), CSNK2B(1), CTBP1(1), CTBP2(1), CTNNB1(2), CXXC4(1), DAAM1(2), DAAM2(2), DKK2(2), DVL3(1), EP300(1), FBXW11(1), FOSL1(1), FZD5(2), FZD7(2), GSK3B(1), LRP5(3), LRP6(1), MAP3K7(3), MAPK8(1), MAPK9(1), MMP7(1), NFAT5(1), NFATC1(1), NFATC2(1), NFATC4(1), NLK(1), PLCB1(4), PLCB2(4), PLCB3(2), PLCB4(1), PORCN(2), PPARD(2), PPP2CA(2), PPP2R1A(4), PPP2R2A(1), PPP2R2B(1), PPP3CC(1), PRICKLE1(3), PRICKLE2(2), PRKACG(1), PRKCA(1), PRKCG(1), RHOA(2), SFRP2(1), SFRP5(1), TBL1X(1), TBL1XR1(1), TCF7L2(2), TP53(279), VANGL2(1), WIF1(3), WNT11(2), WNT16(3), WNT2(1), WNT2B(1), WNT4(1), WNT6(2), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(2), WNT9B(1)	65706417	407	284	270	37	65	52	80	90	120	0	<1.00e-15	<2.93e-14
5	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(1), ATM(5), BUB1(1), BUB1B(2), BUB3(1), CCNA1(2), CCNA2(1), CCNB3(3), CCNH(1), CDAN1(2), CDC20(1), CDC25B(2), CDC6(1), CDC7(2), CDH1(2), CDK2(1), CDKN1A(1), CHEK2(1), E2F2(1), E2F5(1), EP300(1), GADD45A(1), GSK3B(1), HDAC1(1), HDAC3(2), HDAC4(2), HDAC5(1), HDAC6(2), MAD2L2(1), MCM2(2), MCM3(1), MCM4(2), MCM5(2), MPEG1(1), ORC1L(1), ORC4L(1), PRKDC(8), RB1(9), RBL1(1), SKP2(2), TBC1D8(3), TFDP1(2), TP53(279)	48736010	358	283	222	27	56	42	65	80	115	0	<1.00e-15	<2.93e-14
6	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	78	AIFM1(2), APAF1(2), ATM(5), BID(1), BIRC3(2), CASP6(1), CASP7(1), CASP9(1), CHUK(1), CSF2RB(3), FADD(1), IKBKB(1), IRAK1(2), IRAK2(1), IRAK3(2), IRAK4(1), MAP3K14(1), NFKB1(1), NTRK1(4), PIK3CA(2), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R5(1), PPP3CC(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RELA(1), TNF(1), TNFRSF10A(2), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(1), TP53(279), TRAF2(1)	35255671	334	282	198	25	53	42	59	75	105	0	<1.00e-15	<2.93e-14
7	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	EGFR(7), IGF1R(1), PPP2CA(2), PRKCA(1), RB1(9), TEP1(5), TERF1(1), TERT(1), TNKS(1), TP53(279)	12360237	307	281	171	10	50	33	49	65	110	0	<1.00e-15	<2.93e-14
8	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(2), BAK1(1), BID(1), BIRC3(2), CASP2(1), CASP6(1), CASP7(1), CASP9(1), FADD(1), MAP2K4(1), MAP3K1(1), MAP3K14(1), NFKB1(1), PRF1(2), RELA(1), TNF(1), TNFRSF1A(1), TNFSF10(1), TP53(279), TRAF1(4), TRAF2(1)	16033981	305	280	169	10	50	36	48	67	104	0	<1.00e-15	<2.93e-14
9	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	APAF1(2), ATM(5), BID(1), CASP6(1), CASP7(1), CASP9(1), EIF2S1(1), PRKCA(1), PTK2(1), PXN(5), STAT1(2), TLN1(1), TP53(279)	12296579	301	279	165	7	49	33	50	66	103	0	<1.00e-15	<2.93e-14
10	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(5), CDC25B(2), CDK2(1), MYT1(2), RB1(9), TP53(279)	7986534	298	279	162	5	47	33	47	64	107	0	<1.00e-15	<2.93e-14
11	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CDK2(1), CDKN1A(1), CDKN1B(1), E2F2(1), NXT1(1), PRB1(1), TP53(279)	3310452	285	279	149	8	49	33	40	62	101	0	<1.00e-15	<2.93e-14
12	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(1), ATM(5), BRCA1(12), CDKN1A(1), CHEK2(1), GADD45A(1), MAPK8(1), NFKB1(1), RAD50(2), RAD51(1), RBBP8(1), RELA(1), TP53(279)	12930025	307	278	171	6	50	34	45	64	114	0	<1.00e-15	<2.93e-14
13	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(2), ATM(5), ATR(2), BAI1(2), BID(1), CASP9(1), CCNB3(3), CCNG2(1), CD82(1), CDK2(1), CDKN1A(1), CHEK2(1), DDB2(1), EI24(1), GADD45A(1), GADD45B(1), GTSE1(1), PTEN(2), RRM2B(2), SERPINB5(1), SERPINE1(1), SESN1(1), THBS1(2), TP53(279), TSC2(2), ZMAT3(2)	26603590	318	278	182	13	54	35	51	74	104	0	<1.00e-15	<2.93e-14
14	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(2), ATM(5), CDK2(1), CDKN1A(1), GADD45A(1), RB1(9), TP53(279)	8056664	298	278	162	3	48	34	44	65	107	0	<1.00e-15	<2.93e-14
15	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	36	GADD45A(1), MAP2K4(1), MAP3K1(1), MAP3K10(2), MAP3K12(1), MAP3K13(2), MAP3K2(2), MAP3K3(1), MAP3K4(2), MAP3K5(2), MAP3K7(3), MAP3K9(1), MAPK8(1), MAPK9(1), MYEF2(1), PAPPA(3), SHC1(1), TP53(279), TRAF6(2)	21375636	307	278	171	6	51	37	50	65	104	0	<1.00e-15	<2.93e-14
16	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	14	ABL1(1), PIK3CA(2), PIK3R1(1), POLR1C(1), RB1(9), TP53(279)	8259321	293	277	157	12	47	33	43	63	107	0	<1.00e-15	<2.93e-14
17	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(7), DAXX(1), PAX3(5), RARA(1), RB1(9), SP100(4), TNF(1), TNFRSF1A(1), TP53(279)	8081303	308	277	172	6	49	34	47	66	112	0	<1.00e-15	<2.93e-14
18	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(1), DNAJC3(1), EIF2S1(1), MAP3K14(1), NFKB1(1), RELA(1), TP53(279)	4307533	285	277	149	5	48	31	42	63	101	0	<1.00e-15	<2.93e-14
19	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(3), ATM(5), CDKN1A(1), CPB2(1), GADD45A(1), MAPK8(1), TP53(279)	8951891	291	276	155	5	49	33	41	65	103	0	<1.00e-15	<2.93e-14
20	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(5), ATR(2), CHEK2(1), TP53(279)	7496781	287	276	151	3	48	32	40	65	102	0	<1.00e-15	<2.93e-14
21	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(1), TP53(279)	3171868	280	276	144	6	47	31	40	61	101	0	<1.00e-15	<2.93e-14
22	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(5), ATR(2), BRCA1(12), CDC25B(2), CDKN1A(1), CDKN2D(1), CHEK2(1), EP300(1), GADD45A(1), MYT1(2), PRKDC(8), RPS6KA1(1), TP53(279)	18900608	316	280	180	7	49	34	46	71	116	0	1.22e-15	3.42e-14
23	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	53	ALG2(2), BAK1(1), BFAR(2), BTK(1), CAD(5), CASP8AP2(1), DAXX(1), DEDD2(1), DIABLO(1), EGFR(7), EPHB2(1), FADD(1), IL8(1), MAP2K4(1), MAP3K1(1), MAP3K5(2), MAPK8(1), MAPK8IP1(1), MAPK9(1), MET(4), NFAT5(1), NFKB1(1), PFN2(1), PTPN13(4), TP53(279), TPX2(1), TRAF2(1), TUFM(1)	29275634	325	282	189	18	53	40	52	73	107	0	1.33e-15	3.42e-14
24	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(5), ATR(2), BRCA1(12), BRCA2(11), CHEK2(1), FANCA(3), FANCC(2), FANCD2(1), FANCE(1), FANCG(1), HUS1(1), RAD1(1), RAD50(2), RAD51(1), TP53(279)	19936305	323	280	187	6	49	33	47	69	124	1	1.33e-15	3.42e-14
25	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(1), ATM(5), ATR(2), CCNA1(2), CDK2(1), CDKN1A(1), CDKN1B(1), GSK3B(1), HDAC1(1), RB1(9), SKP2(2), TFDP1(2), TP53(279)	13302114	307	280	171	8	48	37	47	66	109	0	1.44e-15	3.56e-14
26	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	63	APAF1(2), BAK1(1), BID(1), BIRC3(2), BNIP3L(1), CASP1(2), CASP2(1), CASP4(1), CASP6(1), CASP7(1), CASP9(1), CHUK(1), FADD(1), IKBKB(1), IRF2(2), IRF3(2), IRF4(1), IRF6(3), MAP2K4(1), MAP3K1(1), NFKB1(1), PRF1(2), RELA(1), TNF(1), TNFRSF1A(1), TNFSF10(1), TP53(279), TRAF1(4), TRAF2(1)	23644549	318	282	182	14	51	39	50	73	105	0	1.67e-15	3.95e-14
27	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(2), IKBKB(1), JAK2(2), LIN7A(1), NFKB1(1), RB1(9), RELA(1), TNF(1), TNFRSF1A(1), TP53(279), USH1C(1)	7976204	299	278	163	5	49	35	45	63	107	0	2.22e-15	5.07e-14
28	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CDK2(1), FBXW7(4), RB1(9), TFDP1(2)	3640638	16	16	16	1	2	3	4	0	7	0	0.00015	0.0033
29	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDK2(1), CDKN1B(1), RB1(9), SKP2(2), TFDP1(2), UBE2M(1)	3779747	16	16	16	2	1	4	4	0	7	0	0.00030	0.0064
30	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNA1(2), CDK2(1), RB1(9), SKP2(2), TFDP1(2)	3735594	16	16	16	3	0	4	4	1	7	0	0.00038	0.0077
31	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	221	ADCYAP1R1(1), ADORA2B(2), ADORA3(2), ADRA1A(1), ADRA2B(3), ADRB2(1), AGTR2(2), AVPR1B(3), AVPR2(1), BDKRB1(4), BDKRB2(3), BRS3(1), C5AR1(2), CALCR(3), CALCRL(1), CCKBR(1), CGA(1), CHRM2(4), CHRM3(3), CHRM5(1), CTSG(1), CYSLTR1(1), DRD1(2), DRD3(1), EDNRA(1), F2(3), F2R(2), F2RL2(1), FPR1(1), FSHB(1), FSHR(4), GABBR1(2), GABBR2(2), GABRA1(2), GABRA2(2), GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(6), GABRB1(2), GABRB3(1), GABRE(3), GABRG1(2), GABRG2(2), GABRQ(2), GALR1(1), GH2(1), GHR(1), GHRHR(1), GHSR(1), GLP2R(1), GLRA1(1), GLRA2(1), GLRA3(4), GPR156(1), GPR35(1), GPR50(2), GRIA1(1), GRIA2(2), GRIA3(2), GRIA4(3), GRID1(3), GRID2(2), GRIK1(1), GRIK2(2), GRIK3(2), GRIK5(2), GRIN2A(3), GRIN2B(3), GRIN2C(1), GRIN2D(3), GRIN3A(3), GRM1(4), GRM3(1), GRM4(1), GRM5(2), GRM6(1), GRM7(4), GRM8(3), GRPR(1), GZMA(2), HCRTR1(1), HCRTR2(1), HRH1(1), HRH4(2), HTR1A(2), HTR1E(2), HTR1F(3), HTR2A(3), HTR2C(4), HTR4(2), HTR5A(2), HTR6(1), LEPR(1), LHCGR(3), MAS1(1), MC2R(3), MC3R(2), MC4R(1), MC5R(2), MCHR2(2), MLNR(1), MTNR1A(1), NMBR(1), NMUR2(2), NPBWR1(1), NPFFR2(2), NR3C1(2), OPRD1(2), OPRK1(1), P2RX1(1), P2RX5(1), P2RY10(2), P2RY13(4), P2RY2(2), P2RY6(1), PARD3(2), PPYR1(2), PRLHR(1), PRLR(2), PRSS2(1), PRSS3(1), PTGDR(1), PTGFR(3), PTH2R(1), RXFP2(1), SCTR(1), SSTR1(1), TAAR6(2), TACR1(1), TACR2(2), TACR3(1), TRPV1(1), TSHR(4), VIPR2(1)	92499928	247	149	246	75	47	29	85	65	21	0	0.00047	0.0093
32	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABRA1(2), GABRA2(2), GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(6), GPHN(2), SRC(4)	5319127	21	21	19	4	4	4	6	5	2	0	0.00053	0.010
33	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(3), NR1H3(4), NR1H4(3), RXRA(2)	2264708	12	12	12	0	2	2	3	2	3	0	0.00090	0.017
34	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(2), GABRA2(2), GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(6), PRKCE(1)	3428866	14	14	14	3	3	3	2	4	2	0	0.0020	0.036
35	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTG1(2), ACTN2(3), ACTN3(2), AMOTL1(1), ASH1L(3), CASK(2), CGN(2), CLDN10(1), CLDN11(2), CLDN15(1), CLDN16(1), CLDN17(2), CLDN18(2), CLDN2(1), CLDN6(1), CLDN9(1), CSDA(1), CSNK2A1(1), CSNK2B(1), CTNNA1(2), CTNNA3(1), CTNNB1(2), CTTN(1), EPB41(2), EPB41L3(5), EXOC3(1), EXOC4(4), F11R(2), GNAI2(1), INADL(2), JAM3(1), KRAS(2), LLGL2(3), MAGI1(2), MAGI2(4), MAGI3(3), MLLT4(2), MPDZ(4), MPP5(1), MRAS(1), MYH1(9), MYH10(3), MYH11(7), MYH13(6), MYH14(2), MYH15(5), MYH2(5), MYH3(4), MYH4(9), MYH7(3), MYH7B(5), MYH8(3), MYH9(3), MYL2(1), NRAS(2), PARD3(2), PARD6A(1), PPP2CA(2), PPP2R1A(4), PPP2R2A(1), PPP2R2B(1), PPP2R3A(2), PPP2R4(1), PRKCA(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCI(2), PRKCQ(3), PRKCZ(2), PTEN(2), RAB3B(1), RHOA(2), RRAS(1), SPTAN1(5), SRC(4), TJAP1(1), TJP1(3), TJP3(1), YES1(1)	82395479	189	141	185	38	29	15	68	50	27	0	0.0021	0.036
36	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	151	ADORA2B(2), ADORA3(2), ADRA1A(1), ADRB2(1), AGTR2(2), AVPR1B(3), AVPR2(1), BDKRB1(4), BDKRB2(3), BRS3(1), CCKBR(1), CCR3(2), CCR6(1), CCR8(1), CCR9(1), CHML(3), CHRM2(4), CHRM3(3), CHRM5(1), CXCR3(2), DRD1(2), DRD3(1), EDNRA(1), F2R(2), F2RL2(1), FPR1(1), FSHR(4), GALR1(1), GHSR(1), GPR173(1), GPR174(1), GPR35(1), GPR37(2), GPR37L1(1), GPR4(2), GPR50(2), GPR77(1), GRPR(1), HCRTR1(1), HCRTR2(1), HRH1(1), HTR1A(2), HTR1E(2), HTR1F(3), HTR2A(3), HTR2C(4), HTR4(2), HTR5A(2), HTR6(1), LHCGR(3), MAS1(1), MC3R(2), MC4R(1), MC5R(2), MLNR(1), MTNR1A(1), NMBR(1), NMUR2(2), OPN1SW(2), OPRD1(2), OPRK1(1), OR10A5(1), OR11A1(1), OR12D3(2), OR5V1(3), OR7C1(2), OR8B8(1), P2RY10(2), P2RY12(1), P2RY13(4), P2RY2(2), P2RY6(1), PPYR1(2), PTGDR(1), PTGFR(3), RRH(1), SSTR1(1), SUCNR1(1)	48728343	135	103	135	30	22	12	52	38	11	0	0.0025	0.043
37	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	26	CASP2(1), FADD(1), LMNA(4), LMNB1(1), MADD(6), MAP2K4(1), MAP3K1(1), MAP3K7(3), MAPK8(1), PAK2(1), PRKDC(8), RB1(9), SPTAN1(5), TNF(1), TNFRSF1A(1), TRAF2(1)	16644802	45	43	45	4	5	11	10	8	11	0	0.0037	0.061
38	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(4), CD3E(2), CD4(1), CREBBP(7), CSK(1), GNAS(3), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTPRC(3), ZAP70(1)	9488232	28	28	27	3	5	3	6	6	8	0	0.0044	0.070
39	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(4), CD3E(2), CD4(1), CREBBP(7), CSK(1), GNAS(3), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTPRC(3), ZAP70(1)	9488232	28	28	27	3	5	3	6	6	8	0	0.0044	0.070
40	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(1), BMP5(1), BMP6(1), BTRC(2), CSNK1A1L(1), CSNK1E(1), FBXW11(1), GLI1(5), GLI2(10), GLI3(2), GSK3B(1), HHIP(2), LRP2(16), PRKACG(1), PTCH1(6), PTCH2(1), STK36(1), WNT11(2), WNT16(3), WNT2(1), WNT2B(1), WNT4(1), WNT6(2), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(2), WNT9B(1)	24713567	71	61	70	10	10	14	26	15	6	0	0.0066	0.10
41	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(2), CCNH(1), CDK2(1), CDKN1A(1), CDKN1B(1), CDKN2C(2), CDKN2D(1), RB1(9), RBL1(1), TFDP1(2)	6856057	21	21	21	7	2	4	8	1	6	0	0.0078	0.12
42	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	46	ACOX1(2), CPT1B(2), CREBBP(7), DUSP1(2), EHHADH(2), EP300(1), HSD17B4(1), LPL(1), ME1(2), MRPL11(1), NCOA1(2), NCOR1(1), NCOR2(1), NR1H3(4), NR2F1(2), PIK3CA(2), PIK3R1(1), PPARA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(1), PTGS2(1), RB1(9), RELA(1), RXRA(2), STAT5A(2), STAT5B(3), TNF(1)	25832777	58	56	58	9	5	8	18	12	15	0	0.0085	0.12
43	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(4), FHL5(2), FSHB(1), FSHR(4), GNAS(3)	3965423	14	14	13	3	4	0	2	5	3	0	0.0090	0.13
44	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	50	ADORA3(2), CCKBR(1), CCR3(2), CELSR1(1), CELSR2(4), CELSR3(6), CHRM2(4), CHRM3(3), CXCR3(2), EDNRA(1), EMR2(1), EMR3(5), F2R(2), FSHR(4), GHRHR(1), GPR116(1), GPR132(2), GPR133(2), GPR55(1), GPR77(1), GRM1(4), GRPR(1), HRH4(2), LGR6(3), LPHN2(1), LPHN3(4), OR8G2(1), P2RY13(4), PTGFR(3), TSHR(4)	25452491	73	60	73	20	11	10	27	19	6	0	0.015	0.21
45	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	96	ADCY1(4), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY9(5), CALM3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CREB3L1(1), CREB3L4(1), CREBBP(7), CTNNB1(2), DCT(2), DVL3(1), EP300(1), FZD5(2), FZD7(2), GNAI2(1), GNAS(3), GSK3B(1), KIT(7), KITLG(1), KRAS(2), MITF(2), NRAS(2), PLCB1(4), PLCB2(4), PLCB3(2), PLCB4(1), POMC(1), PRKACG(1), PRKCA(1), PRKCG(1), TCF7L2(2), TYR(1), WNT11(2), WNT16(3), WNT2(1), WNT2B(1), WNT4(1), WNT6(2), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(2), WNT9B(1)	43571057	101	86	96	28	21	14	30	20	16	0	0.018	0.25
46	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3E(2), CD80(1), CD86(2), GRB2(2), HLA-DRA(1), HLA-DRB1(1), ITK(5), LCK(1), PIK3CA(2), PIK3R1(1)	5774211	18	17	18	8	0	3	8	5	2	0	0.021	0.28
47	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(4), ARHGEF1(3), F2(3), F2R(2), GNA12(1), MAP3K7(3), PIK3CA(2), PIK3R1(1), PLCB1(4), PPP1R12B(4), PRKCA(1), PTK2B(1)	11080969	29	27	29	5	8	7	7	6	1	0	0.024	0.31
48	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	125	ALCAM(1), CADM1(2), CADM3(2), CD22(3), CD274(1), CD276(1), CD34(1), CD4(1), CD80(1), CD86(2), CD8A(1), CDH1(2), CDH2(2), CDH3(2), CDH4(2), CDH5(1), CLDN10(1), CLDN11(2), CLDN15(1), CLDN16(1), CLDN17(2), CLDN18(2), CLDN2(1), CLDN6(1), CLDN9(1), CNTN1(3), CNTN2(1), CNTNAP1(5), CNTNAP2(8), F11R(2), GLG1(3), HLA-A(1), HLA-DRA(1), HLA-DRB1(1), HLA-E(1), HLA-G(3), ICAM1(1), ICAM2(1), ICAM3(1), ITGA4(3), ITGA6(1), ITGA8(3), ITGAL(3), ITGAV(2), ITGB2(2), ITGB7(4), JAM3(1), L1CAM(5), MPZ(2), MPZL1(2), NCAM1(2), NCAM2(4), NEGR1(1), NFASC(3), NLGN1(1), NLGN3(2), NRCAM(2), NRXN1(5), NRXN2(2), NRXN3(2), PDCD1(1), PECAM1(2), PTPRC(3), PTPRF(4), PTPRM(1), PVRL1(1), SDC1(4), SDC2(2), SELE(3), SELP(3), SIGLEC1(2), SPN(1), VCAN(6)	63587893	154	111	153	35	22	28	53	34	17	0	0.025	0.32
49	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	APC(8), BTRC(2), CREBBP(7), CSNK2A1(1), CTBP1(1), CTNNB1(2), GSK3B(1), HDAC1(1), MAP3K7(3), NLK(1), PPARD(2), PPP2CA(2), TLE1(1), WIF1(3)	12038874	35	30	35	8	0	5	9	12	9	0	0.026	0.32
50	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN2(3), ACTN3(2), CSK(1), CTNNA1(2), CTNNB1(2), PECAM1(2), PTK2(1), PXN(5), SRC(4), VCL(2)	8157001	24	24	22	4	2	3	11	3	5	0	0.026	0.32
51	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(2), CREBBP(7), GZMA(2), PRF1(2)	4460489	13	13	13	2	2	1	0	5	5	0	0.027	0.32
52	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(4), CYP2C9(1)	942777	5	5	5	1	0	0	1	4	0	0	0.028	0.33
53	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	192	ACTN2(3), ACTN3(2), APC(8), ARHGEF1(3), ARHGEF12(1), ARHGEF4(2), ARHGEF7(2), ARPC1A(1), ARPC3(1), BDKRB1(4), BDKRB2(3), BRAF(2), CHRM2(4), CHRM3(3), CHRM5(1), CSK(1), CYFIP1(5), CYFIP2(2), DIAPH2(4), DIAPH3(2), DOCK1(4), EGFR(7), F2(3), F2R(2), FGD1(3), FGD3(1), FGF12(1), FGF2(1), FGF23(2), FGF5(1), FGF6(1), FGFR4(1), FN1(1), GNA12(1), GRLF1(6), GSN(1), IQGAP1(2), IQGAP2(6), IQGAP3(2), ITGA1(1), ITGA10(2), ITGA2B(4), ITGA3(2), ITGA4(3), ITGA5(1), ITGA6(1), ITGA8(3), ITGAD(1), ITGAE(1), ITGAL(3), ITGAV(2), ITGAX(1), ITGB2(2), ITGB6(1), ITGB7(4), KRAS(2), LIMK1(1), LIMK2(1), MOS(1), MRAS(1), MSN(2), MYH10(3), MYH14(2), MYH9(3), MYL2(1), MYLK(6), MYLK2(1), NCKAP1(2), NCKAP1L(3), NRAS(2), PAK2(1), PAK3(5), PAK6(2), PAK7(1), PDGFRA(3), PDGFRB(3), PFN2(1), PFN4(1), PIK3CA(2), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R5(1), PIP4K2A(1), PIP4K2B(1), PIP5K1A(1), PIP5K1C(1), PPP1R12A(2), PPP1R12B(4), PTK2(1), PXN(5), RHOA(2), RRAS(1), SCIN(2), SOS1(3), SOS2(1), SSH1(4), SSH2(1), SSH3(3), TIAM1(1), TIAM2(3), VAV1(2), VAV2(4), VAV3(3), VCL(2), WAS(1), WASF2(1)	116072989	240	159	237	64	31	29	88	64	28	0	0.028	0.33
54	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	10	AKR1C4(1), CYP11A1(1), CYP11B1(7), CYP11B2(1), HSD3B1(2), HSD3B2(1)	3699922	13	13	12	4	1	0	6	5	1	0	0.032	0.36
55	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	10	AKR1C4(1), CYP11A1(1), CYP11B1(7), CYP11B2(1), HSD3B1(2), HSD3B2(1)	3699922	13	13	12	4	1	0	6	5	1	0	0.032	0.36
56	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(1), B3GNT7(1), B4GALT2(1), CHST2(5), CHST6(1), FUT8(1), ST3GAL2(2), ST3GAL3(3)	4877454	15	15	15	1	4	3	3	4	1	0	0.044	0.48
57	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	RB1(9)	3070839	9	9	9	2	0	1	3	0	5	0	0.044	0.48
58	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	28	ADRA1A(1), ADRB2(1), CHRM2(4), CHRM3(3), CHRM5(1), DRD1(2), DRD3(1), HRH1(1), HTR1A(2), HTR1E(2), HTR1F(3), HTR2A(3), HTR2C(4), HTR4(2), HTR5A(2), HTR6(1)	10112179	33	28	33	4	5	4	15	8	1	0	0.046	0.48
59	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	90	ADCY1(4), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY9(5), CACNA1C(9), CACNA1D(6), CACNA1F(4), CACNA1S(5), CALM3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CGA(1), EGFR(7), ELK1(2), FSHB(1), GNA11(1), GNAS(3), GRB2(2), ITPR1(3), ITPR2(5), ITPR3(3), KRAS(2), MAP2K3(1), MAP2K4(1), MAP2K6(1), MAP3K1(1), MAP3K2(2), MAP3K3(1), MAP3K4(2), MAPK14(1), MAPK8(1), MAPK9(1), MMP2(1), NRAS(2), PLA2G12A(1), PLA2G12B(1), PLA2G2F(1), PLA2G4A(1), PLA2G6(1), PLCB1(4), PLCB2(4), PLCB3(2), PLCB4(1), PLD1(1), PLD2(1), PRKACG(1), PRKCA(1), PTK2B(1), SOS1(3), SOS2(1), SRC(4)	53962243	125	100	119	33	16	14	50	30	15	0	0.046	0.48
60	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(4), GABBR1(2), GPRC5A(1), GPRC5C(2), GPRC5D(1), GRM1(4), GRM3(1), GRM4(1), GRM5(2), GRM7(4), GRM8(3)	9045165	25	25	25	9	8	3	9	4	1	0	0.050	0.51
61	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(4), CD38(2), ENPP1(2), ENPP3(2), NADSYN1(1), NNMT(1), NNT(4), NT5E(2)	6608001	18	17	18	2	2	2	4	7	3	0	0.052	0.51
62	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACADM(1), ACOX1(2), ACSL1(2), ACSL3(2), ACSL4(1), ACSL6(1), ADIPOQ(1), ANGPTL4(2), CPT1A(2), CPT1B(2), CPT1C(1), CPT2(1), CYP27A1(1), CYP4A11(4), CYP4A22(1), CYP7A1(1), CYP8B1(2), DBI(1), EHHADH(2), FABP2(1), FABP3(2), FABP4(1), FADS2(2), GK2(2), HMGCS2(1), LPL(1), ME1(2), MMP1(1), NR1H3(4), OLR1(1), PDPK1(1), PPARA(1), PPARD(2), RXRA(2), RXRB(2), SCP2(1), SLC27A2(1), SLC27A4(1), SORBS1(2), UBC(3), UCP1(1)	28493267	65	60	64	14	6	10	27	11	11	0	0.052	0.51
63	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	129	ACTG1(2), CHAD(1), COL11A1(5), COL11A2(4), COL17A1(3), COL1A1(1), COL1A2(2), COL2A1(1), COL3A1(4), COL4A1(3), COL4A2(1), COL4A4(3), COL4A6(5), COL5A1(1), COL5A2(2), COL5A3(7), COL6A3(11), COL6A6(6), COMP(3), DSC1(3), DSC2(1), DSC3(2), DSG1(3), DSG2(1), DSG3(3), DSG4(3), FN1(1), GJA1(2), GJA5(1), GJA8(2), GJB4(1), GJB5(1), GJB6(1), GJC3(1), GJD2(1), INA(1), ITGA6(1), KRT1(1), KRT12(1), KRT13(1), KRT2(1), KRT23(1), KRT24(1), KRT25(2), KRT27(1), KRT28(1), KRT31(1), KRT32(1), KRT33A(1), KRT35(1), KRT4(3), KRT6A(3), KRT6B(3), KRT6C(2), KRT71(1), KRT72(4), KRT73(2), KRT77(2), KRT78(2), KRT79(2), KRT82(1), KRT85(2), KRT9(1), LAMA1(6), LAMA2(8), LAMA3(7), LAMA4(2), LAMB1(5), LAMB2(3), LAMB3(1), LAMB4(4), LAMC1(3), LAMC2(1), LAMC3(4), LMNA(4), LMNB1(1), NES(5), RELN(8), SPP1(1), THBS1(2), THBS2(4), THBS3(3), THBS4(1), TNC(1), TNN(4), TNR(3), TNXB(4), VIM(2), VWF(4)	102137276	227	147	227	59	24	41	81	49	32	0	0.054	0.52
64	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	63	AGTR2(2), AVPR1B(3), AVPR2(1), BDKRB1(4), BDKRB2(3), BRS3(1), CCKBR(1), CCR3(2), CCR6(1), CCR8(1), CXCR3(2), EDNRA(1), FPR1(1), FSHR(4), GALR1(1), GHSR(1), GPR77(1), GRPR(1), LHCGR(3), MC2R(3), MC3R(2), MC4R(1), MC5R(2), NMBR(1), OPRD1(2), OPRK1(1), PPYR1(2), SSTR1(1), TACR1(1), TACR2(2), TACR3(1), TSHR(4)	21138845	57	46	57	13	12	4	20	16	5	0	0.054	0.52
65	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(3), AGTR2(2), BDKRB2(3), KNG1(1), NOS3(2)	3776727	11	11	11	2	4	2	2	3	0	0	0.055	0.52
66	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	122	ABL1(1), ABLIM1(1), ABLIM3(1), ARHGEF12(1), DCC(3), DPYSL5(2), EFNA4(1), EFNB1(1), EFNB2(1), EPHA1(4), EPHA2(2), EPHA3(3), EPHA5(1), EPHA6(2), EPHA7(7), EPHB1(4), EPHB2(1), EPHB3(4), EPHB4(1), EPHB6(1), FES(3), GNAI2(1), GSK3B(1), KRAS(2), L1CAM(5), LIMK1(1), LIMK2(1), LRRC4C(2), MET(4), NCK2(1), NFAT5(1), NFATC1(1), NFATC2(1), NFATC4(1), NGEF(3), NRAS(2), NRP1(1), NTN4(1), NTNG1(3), PAK2(1), PAK3(5), PAK6(2), PAK7(1), PLXNA1(1), PLXNA2(3), PLXNA3(1), PLXNB1(2), PLXNC1(1), PPP3CC(1), PTK2(1), RASA1(1), RHOA(2), RND1(2), ROBO1(4), ROBO2(2), ROBO3(3), SEMA3A(2), SEMA3D(2), SEMA3E(1), SEMA3G(2), SEMA4A(1), SEMA4B(1), SEMA4C(1), SEMA4D(1), SEMA4F(2), SEMA4G(1), SEMA5B(1), SEMA6A(1), SEMA6C(1), SLIT1(5), SLIT2(2), SLIT3(6), SRGAP1(2), SRGAP2(2), UNC5A(1), UNC5B(3), UNC5C(3), UNC5D(2)	78278978	153	127	151	53	27	21	57	36	12	0	0.056	0.53
67	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPL(2), ALPP(2), FPGS(1), SPR(2)	2149074	7	7	7	0	2	4	0	0	1	0	0.057	0.53
68	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3E(2), HLA-A(1), ICAM1(1), ITGAL(3), ITGB2(2), PRF1(2)	3586909	13	11	12	2	2	1	3	5	2	0	0.058	0.53
69	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(2), CD4(1), CD8A(1), CIITA(1), CTSL1(3), HLA-A(1), HLA-DRA(1), HLA-DRB1(1), HLA-E(1), HLA-G(3), HSP90AA1(2), HSPA5(2), IFNA1(2), IFNA13(2), IFNA5(1), IFNA8(1), KIR2DL1(1), KIR2DL3(2), KIR2DL4(2), KIR3DL1(2), KIR3DL2(1), KIR3DL3(3), KLRC2(2), KLRC3(1), PDIA3(2), PSME1(2), RFX5(1), RFXANK(1), RFXAP(1), TAPBP(3)	20221146	49	43	48	13	4	10	12	14	9	0	0.070	0.62
70	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	APC(8), CTNNB1(2), GJA1(2), GSK3B(1), IRAK1(2), LBP(2), NFKB1(1), PDPK1(1), PIK3CA(2), PIK3R1(1), PPP2CA(2), RELA(1), TIRAP(1), TLR4(4)	12004974	30	27	30	10	3	5	12	6	4	0	0.071	0.62
71	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	15	ACP2(1), ACP6(2), ACPP(2), ENPP1(2), ENPP3(2), FLAD1(3), MTMR1(2), MTMR6(2), TYR(1)	6674015	17	17	17	4	3	1	4	5	4	0	0.071	0.62
72	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(4), CSF2RB(3), IGF1R(1), KIT(7), KITLG(1), PIK3CA(2), PIK3R1(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	8988473	22	22	22	7	7	3	3	6	3	0	0.073	0.62
73	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	CASP6(1), CASP7(1), DAXX(1), FADD(1), LMNA(4), LMNB1(1), MAP2K4(1), MAP3K1(1), MAP3K7(3), MAPK8(1), PAK2(1), PRKDC(8), PTPN13(4), RB1(9), RIPK2(1), SPTAN1(5)	18062815	43	39	43	4	3	8	11	11	10	0	0.074	0.62
74	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(5), AASDHPPT(1), AASS(2), KARS(1)	3198163	9	9	9	1	0	0	3	4	2	0	0.077	0.64
75	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	88	ADCY1(4), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY9(5), DRD1(2), EGFR(7), GJA1(2), GJD2(1), GNA11(1), GNAI2(1), GNAS(3), GRB2(2), GRM1(4), GRM5(2), GUCY1A3(1), GUCY2C(3), HTR2A(3), HTR2C(4), ITPR1(3), ITPR2(5), ITPR3(3), KRAS(2), MAP3K2(2), NPR1(1), NPR2(2), NRAS(2), PDGFC(1), PDGFRA(3), PDGFRB(3), PLCB1(4), PLCB2(4), PLCB3(2), PLCB4(1), PRKACG(1), PRKCA(1), PRKCG(1), PRKG1(1), SOS1(3), SOS2(1), SRC(4), TJP1(3), TUBA3C(3), TUBA4A(3), TUBB1(1), TUBB3(2), TUBB4(2), TUBB8(2)	55308101	124	100	118	36	19	13	49	32	11	0	0.079	0.64
76	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT1(1), B3GALT2(2), B3GNT5(1), FUT1(1), ST3GAL3(3)	3040139	9	9	9	1	3	1	3	0	2	0	0.079	0.64
77	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(4), PDXK(1), PDXP(1), PSAT1(1)	2140556	7	7	7	1	0	1	3	2	1	0	0.080	0.64
78	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	23	AKR1B1(3), UGDH(2), UGT1A10(2), UGT1A3(1), UGT1A5(1), UGT1A7(1), UGT1A8(2), UGT1A9(2), UGT2A1(3), UGT2A3(1), UGT2B10(2), UGT2B11(1), UGT2B17(1), UGT2B4(1), UGT2B7(1), XYLB(1)	10765241	25	24	25	6	2	5	7	6	5	0	0.081	0.64
79	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CSF1R(1), EGFR(7), GRB2(2), MET(4), PDGFRA(3), PRKCA(1), SH3GLB2(2), SRC(4)	8788231	24	22	22	7	1	3	12	7	1	0	0.083	0.65
80	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	CDK2(1), CDKN1A(1), CDKN1B(1), NFKB1(1), PIK3CA(2), PIK3R1(1), RB1(9), RELA(1), TFDP1(2)	8593973	19	19	19	7	2	4	5	1	7	0	0.086	0.65
81	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(8), CSNK1E(1), CTNNB1(2), DVL3(1), FOSL1(1), FZD5(2), FZD7(2), GSK3B(1), LDLR(3), MAPK9(1), PLAU(2), PPP2R5C(1), PRKCA(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCI(2), PRKCQ(3), PRKCZ(2), PRKD1(2), RHOA(2), WNT11(2), WNT16(3), WNT2(1), WNT2B(1), WNT4(1), WNT6(2), WNT7A(2), WNT7B(2)	23439976	54	48	53	17	10	9	16	12	7	0	0.086	0.65
82	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	MAP2K3(1), MAP2K6(1), MAP3K1(1), MAPK14(1), NFKB1(1), PIK3CA(2), PIK3R1(1), RB1(9), RELA(1)	8304629	18	18	18	7	3	2	4	3	6	0	0.087	0.65
83	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), HBXIP(1), PTK2B(1), SHC1(1), SOS1(3), SRC(4)	3828611	12	12	10	3	0	1	11	0	0	0	0.091	0.68
84	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD3E(2), CD8A(1), ICAM1(1), ITGAL(3), ITGB2(2), PTPRC(3)	4679845	12	12	12	2	3	2	4	2	1	0	0.096	0.70
85	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(2), ARHGEF1(3), GNA12(1), MYL2(1), MYLK(6), PLCB1(4), PPP1R12B(4), PRKCA(1)	9217804	22	22	22	2	4	3	8	6	1	0	0.098	0.70
86	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	FUCA2(1), GLB1(2), HEXA(2), HEXB(1), LCT(6), MAN2B1(3), MAN2B2(3), MAN2C1(1), MANBA(1), NEU1(1), NEU3(1)	8442092	22	21	22	5	1	3	10	6	2	0	0.100	0.70
87	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), GLB1(2), HEXA(2), HEXB(1), LCT(6), ST3GAL2(2), ST6GALNAC3(2), ST8SIA1(2), ST8SIA5(1)	7165599	20	19	20	4	1	2	11	4	2	0	0.10	0.70
88	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(4), FARSB(1), PAH(3), TAT(2)	3998421	10	10	10	3	1	1	2	4	2	0	0.10	0.70
89	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CHUK(1), CREBBP(7), DUSP1(2), EP300(1), IKBKB(1), IL8(1), MAP2K3(1), MAP2K6(1), MAP3K14(1), MAP3K7(3), MAPK14(1), NFKB1(1), NR3C1(2), RELA(1), TGFBR2(3), TNF(1)	12852953	28	27	28	5	4	4	6	10	4	0	0.10	0.70
90	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGFR(7), ERBB3(2), NRG1(4)	4746778	13	13	13	5	0	2	6	4	1	0	0.10	0.70
91	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD34(1), CD3E(2), CD4(1), CD8A(1), CSF3(1), IL8(1), KITLG(1)	2853376	8	8	8	3	1	1	4	1	1	0	0.10	0.70
92	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(3), CYP2A6(2), CYP2A7(3), NAT2(1), XDH(1)	3618823	11	11	11	5	0	3	5	3	0	0	0.10	0.70
93	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), FUT1(1), FUT9(1), GCNT2(2), ST8SIA1(2)	2495432	7	7	7	1	1	2	1	1	2	0	0.11	0.71
94	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	HTR2C(4), PLCB1(4), TUB(1)	3237978	9	9	9	0	0	3	3	3	0	0	0.11	0.71
95	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(2), AOC2(4), AOC3(1), CES1(1)	2553721	8	8	8	3	1	0	2	2	3	0	0.11	0.71
96	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(2), SPCS1(1), SPCS3(2)	1385811	5	5	5	0	0	1	2	2	0	0	0.11	0.73
97	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(2), ACO2(1), AFMID(1), CS(1), HAO1(2), HAO2(1), HYI(1), MDH2(1), MTHFD1(2), MTHFD1L(3)	6081689	15	15	15	0	3	2	5	3	2	0	0.11	0.73
98	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(1), ICAM1(1), ITGA4(3), ITGAL(3), ITGB2(2), PECAM1(2), SELE(3)	5803736	15	14	15	3	2	2	5	4	2	0	0.12	0.76
99	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(2), G6PD(4), GCLM(1), GPX6(3), GSR(2), GSS(3), GSTA1(1), GSTA2(1), GSTA5(1), GSTM1(1), GSTM5(1), GSTO2(1), MGST1(1), MGST2(1), TXNDC12(1)	8661487	24	21	24	5	0	6	10	5	3	0	0.12	0.76
100	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ABP1(2), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ADHFE1(1), ALDH3A1(1), AOC2(4), AOC3(1), AOX1(4), DBH(2), DCT(2), DDC(1), MAOA(2), MAOB(1), TAT(2), TPO(4), TYR(1)	13306647	32	29	32	10	3	3	9	12	5	0	0.13	0.77
101	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(2), ACO2(1), CS(1), HAO1(2), HAO2(1), HYI(1), MDH2(1), MTHFD1(2), MTHFD1L(3)	5795835	14	14	14	0	3	2	4	3	2	0	0.13	0.79
102	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	185	ACTG1(2), ACTN2(3), ACTN3(2), ARHGAP5(2), BIRC3(2), BRAF(2), CHAD(1), COL11A1(5), COL11A2(4), COL1A1(1), COL1A2(2), COL2A1(1), COL3A1(4), COL4A1(3), COL4A2(1), COL4A4(3), COL4A6(5), COL5A1(1), COL5A2(2), COL5A3(7), COL6A3(11), COL6A6(6), COMP(3), CTNNB1(2), DOCK1(4), EGFR(7), ELK1(2), ERBB2(4), FARP2(1), FIGF(1), FLNA(1), FLNB(3), FLNC(3), FLT1(2), FN1(1), GRB2(2), GRLF1(6), GSK3B(1), HGF(2), IGF1R(1), ITGA1(1), ITGA10(2), ITGA2B(4), ITGA3(2), ITGA4(3), ITGA5(1), ITGA6(1), ITGA8(3), ITGAV(2), ITGB6(1), ITGB7(4), KDR(1), LAMA1(6), LAMA2(8), LAMA3(7), LAMA4(2), LAMB1(5), LAMB2(3), LAMB3(1), LAMB4(4), LAMC1(3), LAMC2(1), LAMC3(4), MAPK8(1), MAPK9(1), MET(4), MYL2(1), MYLK(6), MYLK2(1), PAK2(1), PAK3(5), PAK6(2), PAK7(1), PDGFC(1), PDGFRA(3), PDGFRB(3), PDPK1(1), PGF(1), PIK3CA(2), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R5(1), PIP5K1C(1), PPP1R12A(2), PRKCA(1), PRKCG(1), PTEN(2), PTK2(1), PXN(5), RAPGEF1(2), RELN(8), RHOA(2), SHC1(1), SHC4(2), SOS1(3), SOS2(1), SPP1(1), SRC(4), THBS1(2), THBS2(4), THBS3(3), THBS4(1), TLN1(1), TLN2(3), TNC(1), TNN(4), TNR(3), TNXB(4), VAV1(2), VAV2(4), VAV3(3), VCL(2), VEGFA(1), VWF(4)	153352397	306	185	302	84	30	47	122	63	44	0	0.13	0.79
103	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1C4(1), CYP11B1(7), CYP11B2(1), HSD17B2(1), HSD3B1(2), HSD3B2(1), METTL6(1), PRMT5(2), PRMT8(3), SRD5A2(1), SULT1E1(1), SULT2A1(1), UGT1A10(2), UGT1A3(1), UGT1A5(1), UGT1A7(1), UGT1A8(2), UGT1A9(2), UGT2A1(3), UGT2A3(1), UGT2B10(2), UGT2B11(1), UGT2B17(1), UGT2B4(1), UGT2B7(1), WBSCR22(1)	20724733	42	42	41	12	3	4	14	15	6	0	0.13	0.80
104	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	5	DAG1(3), ITPKB(4)	2271516	7	6	7	0	2	1	2	1	1	0	0.13	0.80
105	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	41	CSK(1), DAG1(3), EPHB2(1), FBXW7(4), GRB2(2), ITK(5), ITPKB(4), LCK(1), LCP2(1), NFAT5(1), NFKB1(1), PAK2(1), PAK3(5), PAK6(2), PAK7(1), PTPRC(3), RASGRP1(1), RASGRP2(1), RASGRP3(2), SOS1(3), SOS2(1), VAV1(2), ZAP70(1)	22947628	47	45	47	16	6	6	20	10	5	0	0.14	0.80
106	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), UGDH(2), UXS1(2)	1771511	5	5	4	0	0	1	2	1	1	0	0.14	0.80
107	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(4), ADRB2(1), CFTR(2), GNAS(3), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	5265656	13	13	12	0	5	0	3	2	3	0	0.14	0.80
108	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	EGFR(7), ELK1(2), GNAS(3), GRB2(2), IGF1R(1), KLK2(1), MKNK1(1), NGFR(1), PDGFRA(3), PPP2CA(2), PTPRR(1), RPS6KA1(1), RPS6KA5(1), SHC1(1), SOS1(3), SRC(4), STAT3(1)	14127228	35	33	32	12	0	4	19	7	5	0	0.14	0.80
109	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	239	ACVR1(2), ACVR1B(1), ACVR2B(3), AMHR2(1), BMP2(1), BMPR1A(1), BMPR1B(1), BMPR2(3), CCL15(1), CCL17(1), CCL27(1), CCL28(1), CCL7(1), CCR3(2), CCR6(1), CCR8(1), CCR9(1), CNTFR(2), CSF1(1), CSF1R(1), CSF2RB(3), CSF3(1), CSF3R(1), CXCL13(1), CXCL9(1), CXCR3(2), EDA(2), EGFR(7), EPOR(1), FLT1(2), FLT3(2), FLT4(3), GH2(1), GHR(1), HGF(2), IFNA1(2), IFNA13(2), IFNA5(1), IFNA8(1), IFNAR2(1), IFNB1(1), IL10RA(1), IL10RB(1), IL11RA(1), IL12RB2(3), IL13(2), IL17RA(1), IL17RB(2), IL18R1(2), IL18RAP(2), IL19(1), IL20RA(2), IL21R(3), IL22(1), IL24(1), IL25(1), IL28A(1), IL28RA(1), IL2RA(2), IL2RB(1), IL4R(2), IL5RA(1), IL6R(1), IL7R(3), IL8(1), INHBA(3), KDR(1), KIT(7), KITLG(1), LEPR(1), LIFR(2), LTBR(1), MET(4), NGFR(1), OSMR(2), PDGFC(1), PDGFRA(3), PDGFRB(3), PPBP(2), PRLR(2), TGFBR2(3), TNF(1), TNFRSF10A(2), TNFRSF10D(1), TNFRSF1A(1), TNFRSF9(1), TNFSF10(1), TNFSF13B(1), TNFSF14(1), TNFSF8(1), TPO(4), VEGFA(1), XCL2(1)	75845175	155	119	154	31	18	24	49	49	15	0	0.14	0.80
110	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(2), CR2(1), HLA-DRA(1), HLA-DRB1(1), ICAM1(1), ITGAL(3), ITGB2(2), PTPRC(3)	6542065	15	15	15	2	2	3	2	5	3	0	0.14	0.80
111	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD3E(2), CD4(1), ICAM1(1), ITGAL(3), ITGB2(2), PTPRC(3)	4972456	12	12	12	2	2	2	5	2	1	0	0.14	0.80
112	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(7), EP300(1), IL7R(3), JAK3(3), LCK(1), PIK3CA(2), PIK3R1(1), PTK2B(1), STAT5A(2), STAT5B(3)	11985301	24	24	24	7	2	3	6	7	6	0	0.15	0.80
113	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	18	CAMK2B(2), CAMK2D(1), CAMK2G(1), DAG1(3), ITPKB(4), ITPR1(3), ITPR2(5), ITPR3(3), NFAT5(1), PDE6A(3), PDE6B(2), PDE6C(2), PDE6H(1), TF(1)	14994531	32	30	32	5	3	4	8	8	9	0	0.15	0.80
114	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(1), ICAM1(1), ITGA4(3), ITGAL(3), ITGB2(2), PECAM1(2), SELE(3), SELP(3)	7578637	18	17	18	5	2	2	6	5	3	0	0.15	0.80
115	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3E(2), CXCR3(2), ETV5(1), IL12RB2(3), IL18R1(2), JAK2(2), MAP2K6(1), MAPK14(1), MAPK8(1), STAT4(1), TYK2(2)	8053562	18	18	18	4	1	5	4	7	1	0	0.15	0.80
116	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1B(1), ADH1C(1), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), AKR1C1(2), AKR1C4(1), ALDH3A1(1), CYP1A1(2), CYP1A2(1), CYP1B1(1), CYP2B6(1), CYP2C18(2), CYP2C19(4), CYP2C9(1), CYP2E1(1), CYP2F1(1), CYP3A43(1), DHDH(1), EPHX1(3), GSTA1(1), GSTA2(1), GSTA5(1), GSTM1(1), GSTM5(1), GSTO2(1), MGST1(1), MGST2(1), UGT1A10(2), UGT1A3(1), UGT1A5(1), UGT1A7(1), UGT1A8(2), UGT1A9(2), UGT2A1(3), UGT2A3(1), UGT2B10(2), UGT2B11(1), UGT2B17(1), UGT2B4(1), UGT2B7(1)	24291455	56	47	56	16	1	8	21	16	10	0	0.15	0.80
117	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(2), BMPR1A(1), BMPR1B(1), BMPR2(3)	2802426	7	7	7	1	0	2	2	3	0	0	0.15	0.80
118	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	89	CABIN1(2), CALM3(1), CAMK2B(2), CAMK4(3), CD3E(2), CDKN1A(1), CREBBP(7), CSNK2A1(1), CSNK2B(1), EP300(1), FOS(1), FOSL1(1), GATA3(1), GRLF1(6), GSK3A(2), GSK3B(1), IFNA1(2), IFNB1(1), IL13(2), IL2RA(2), IL8(1), ITK(5), KPNA5(1), MAPK14(1), MAPK8(1), MAPK9(1), MEF2A(1), MEF2D(1), MYF5(2), NCK2(1), NFAT5(1), NFATC1(1), NFATC2(1), NFATC4(1), NPPB(2), NUP214(1), OPRD1(2), PPP3CC(1), PTPRC(3), RELA(1), SLA(1), TNF(1), TRAF2(1), TRPV6(2), VAV1(2), VAV2(4), VAV3(3)	38005796	83	69	82	25	6	13	28	22	14	0	0.15	0.80
119	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(4), CAMK2B(2), CAMK2D(1), CAMK2G(1), GNAS(3), GRB2(2), MAPK14(1), PIK3CA(2), PIK3R1(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(1), RPS6KA1(1), RPS6KA5(1), SOS1(3)	12115797	26	25	25	9	7	1	8	6	4	0	0.16	0.80
120	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(1), DYRK1B(2), GLI2(10), GLI3(2), GSK3B(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	6802508	19	17	19	2	4	3	7	4	1	0	0.16	0.80
121	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(4), CD38(2), ENPP1(2), ENPP3(2), NADK(1), NADSYN1(1), NNMT(1), NNT(4), NT5C1A(1), NT5C1B(1), NT5C3(1), NT5E(2)	9598148	22	20	22	3	4	2	4	9	3	0	0.16	0.80
122	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	15	BCAT2(2), COASY(1), DPYD(3), DPYS(1), ENPP1(2), ENPP3(2), ILVBL(1), PANK3(1), UPB1(1), VNN1(3)	7033922	17	17	17	5	1	0	7	3	6	0	0.16	0.80
123	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(12), CREBBP(7), EP300(1), GTF2E1(1), HDAC1(1), HDAC3(2), HDAC4(2), HDAC5(1), HDAC6(2), MEF2C(1), NCOR2(1), PELP1(1), TBP(4)	19081625	36	35	34	10	1	1	8	5	21	0	0.16	0.80
124	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	EIF2B5(4), EIF2S1(1), EIF4EBP1(1), GSK3B(1), IGF1R(1), INPPL1(1), PDPK1(1), PIK3CA(2), PIK3R1(1), PPP2CA(2), PTEN(2), RPS6(1)	8486033	18	18	18	4	2	2	8	2	4	0	0.16	0.81
125	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP2(1), ACPP(2), ENPP1(2), ENPP3(2), FLAD1(3), TYR(1)	4339938	11	11	11	2	1	0	4	3	3	0	0.16	0.81
126	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	6	ABO(1), FUT1(1), ST3GAL3(3)	1549273	5	5	5	0	3	0	1	0	1	0	0.17	0.82
127	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	29	AKR1C4(1), CYP11B1(7), CYP11B2(1), HSD17B2(1), HSD3B1(2), HSD3B2(1), SRD5A2(1), SULT1E1(1), SULT2A1(1), UGT1A10(2), UGT1A3(1), UGT1A5(1), UGT1A7(1), UGT1A8(2), UGT1A9(2), UGT2B4(1)	11603165	26	26	25	6	1	3	7	11	4	0	0.17	0.82
128	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(1), AMY2A(1), ENPP1(2), ENPP3(2), G6PC(1), GAA(2), GANAB(1), GPI(2), GYS1(1), HK1(1), HK2(1), HK3(3), MGAM(5), PYGM(3), SI(10), UGDH(2), UGT1A10(2), UGT1A3(1), UGT1A5(1), UGT1A7(1), UGT1A8(2), UGT1A9(2), UGT2B4(1), UXS1(2)	24130556	50	46	49	12	6	7	17	13	7	0	0.17	0.82
129	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	CHUK(1), FADD(1), IKBKB(1), IRAK1(2), MAP3K1(1), MAP3K14(1), MAP3K7(3), NFKB1(1), RELA(1), TLR4(4), TNF(1), TNFAIP3(4), TNFRSF1A(1), TRAF6(2)	10258386	24	22	24	3	4	7	7	6	0	0	0.17	0.82
130	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	18	ABO(1), B3GNT2(1), B3GNT4(2), B3GNT5(1), B4GALT2(1), FUT1(1), FUT9(1), GCNT2(2), ST3GAL6(1), ST8SIA1(2)	5826445	13	13	13	1	3	3	1	3	3	0	0.18	0.82
131	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	81	ABL1(1), ABL2(1), BRAF(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CBLB(1), CBLC(3), CDKN1A(1), CDKN1B(1), EGFR(7), EIF4EBP1(1), ELK1(2), ERBB2(4), ERBB3(2), GRB2(2), GSK3B(1), KRAS(2), MAP2K4(1), MAPK8(1), MAPK9(1), NCK2(1), NRAS(2), NRG1(4), NRG2(1), PAK2(1), PAK3(5), PAK6(2), PAK7(1), PIK3CA(2), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R5(1), PLCG2(1), PRKCA(1), PRKCG(1), PTK2(1), RPS6KB2(1), SHC1(1), SHC4(2), SOS1(3), SOS2(1), SRC(4), STAT5A(2), STAT5B(3)	42895403	86	77	81	30	6	12	39	19	10	0	0.18	0.82
132	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(2), CD4(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PTPRC(3), ZAP70(1)	4122167	10	10	10	2	0	2	5	1	2	0	0.18	0.82
133	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	49	ALOX12(1), ALOX15(1), ALOX15B(2), ALOX5(1), CYP2B6(1), CYP2C18(2), CYP2C19(4), CYP2C9(1), CYP2E1(1), CYP2J2(1), CYP4A11(4), CYP4A22(1), CYP4F2(1), DHRS4(1), EPHX2(1), GPX6(3), PLA2G12A(1), PLA2G12B(1), PLA2G2F(1), PLA2G4A(1), PLA2G6(1), PTGDS(1), PTGIS(3), PTGS1(1), PTGS2(1), TBXAS1(2)	16484463	39	37	38	7	3	7	17	7	5	0	0.18	0.82
134	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	9	PDE1A(1), PDE1B(1), PLCB1(4), PLCB2(4), TRH(1)	4678660	11	11	11	0	0	3	4	4	0	0	0.18	0.82
135	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CSF1(1), LDLR(3), LPL(1)	2420573	7	6	7	1	1	2	3	1	0	0	0.18	0.82
136	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(3), FOS(1), GRB2(2), JAK2(2), SHC1(1), SOS1(3), STAT5A(2), STAT5B(3)	7111349	17	17	17	4	1	1	11	2	2	0	0.18	0.82
137	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(1), ICAM1(1), ITGAL(3), ITGB2(2), PECAM1(2), SELE(3)	5128781	12	12	12	3	2	2	4	3	1	0	0.18	0.82
138	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	FUCA2(1), GLB1(2), HEXA(2), HEXB(1), LCT(6), MAN2C1(1), MANBA(1), NEU1(1), NEU3(1)	6901890	16	16	16	2	1	3	7	3	2	0	0.18	0.82
139	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	13	GALNT1(3), GALNT10(1), GALNT2(1), GALNT3(1), GALNT4(1), GALNT6(2), GALNT8(2), ST3GAL2(2), WBSCR17(1)	6288236	14	14	14	4	1	3	3	5	2	0	0.19	0.82
140	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(1), NR3C1(2), RXRA(2), TNF(1)	2478019	6	6	6	2	0	1	2	2	1	0	0.19	0.82
141	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ADCY3(2), ADCY9(5), ARF5(1), ARF6(1), ARL4D(1), ATP6V0A2(1), ATP6V0D1(1), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(1), ATP6V1F(1), ERO1L(1), GNAS(3), PDIA4(3), PLCG2(1), PRKCA(1), SEC61A1(2), SEC61A2(1), TRIM23(3)	15934186	34	33	32	7	6	3	10	9	6	0	0.19	0.82
142	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	APC(8), AR(1), BRAF(2), CCL15(1), DAG1(3), EGFR(7), GNA11(1), ITPKB(4), ITPR1(3), ITPR2(5), ITPR3(3), KCNJ9(1), MAPK14(1), PHKA2(2), PIK3CA(2), PIK3R1(1), PITX2(1), SRC(4)	22662155	50	43	48	15	2	5	14	19	10	0	0.19	0.82
143	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25B(2), CSK(1), GRB2(2), PRKCA(1), SRC(4)	4032268	10	10	8	1	1	0	8	0	1	0	0.19	0.82
144	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	32	ATF1(3), DUSP1(2), EEF2K(2), ELK1(2), GADD45A(1), MAP2K3(1), MAP2K4(1), MAP2K6(1), MAP3K10(2), MAP3K4(2), MAP3K5(2), MAP3K7(3), MAPK14(1), MAPKAPK5(1), MKNK1(1), MYEF2(1), NFKB1(1), SRF(1), TRAF6(2)	14196059	30	29	30	4	5	4	10	6	5	0	0.19	0.82
145	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	38	ALK(3), AR(1), NR1D2(1), NR1H3(4), NR1I2(1), NR1I3(1), NR2F1(2), NR2F2(1), NR3C1(2), NR4A2(3), NR5A2(1), PGR(1), PPARA(1), PPARD(2), RARA(1), RARG(1), ROR1(4), RORA(2), RORC(1), RXRA(2), RXRB(2), VDR(1)	17446169	38	37	38	8	6	4	13	10	5	0	0.20	0.82
146	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	30	ACVR1(2), APC(8), BMP10(2), BMP2(1), BMP5(1), BMPR1A(1), BMPR2(3), CHRD(1), CTNNB1(2), GSK3B(1), MAP3K7(3), MEF2C(1), MYL2(1), NPPA(1), NPPB(2), RFC1(2), TGFBR2(3), TGFBR3(2)	15265984	37	31	37	14	3	5	15	10	4	0	0.20	0.82
147	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	12	IL10RA(1), IL22(1), JAK2(2), JAK3(3), STAT1(2), STAT3(1), STAT5A(2), STAT5B(3), TYK2(2)	7596702	17	17	17	4	2	1	8	4	2	0	0.20	0.82
148	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), ACAT2(1), OXCT1(2)	1563470	5	4	5	2	0	1	2	2	0	0	0.20	0.82
149	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), ELK1(2), FOS(1), GRB2(2), IL2RA(2), IL2RB(1), JAK3(3), LCK(1), MAPK8(1), SHC1(1), SOS1(3), STAT5A(2), STAT5B(3)	9940917	23	22	23	4	2	4	14	2	1	0	0.20	0.82
150	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(5), MAP2(7), PPP2CA(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCE(1)	8072884	18	17	18	6	1	0	8	6	3	0	0.20	0.82
151	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2)	542387	2	2	2	1	0	0	2	0	0	0	0.20	0.82
152	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(1), ELK1(2), FOS(1), GRB2(2), INSR(6), IRS1(6), MAPK8(1), PIK3CA(2), PIK3R1(1), RASA1(1), SHC1(1), SLC2A4(1), SOS1(3), SRF(1)	10677923	29	24	29	7	0	5	16	6	2	0	0.20	0.82
153	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(1), DLG4(2), EPHB2(1), F2(3), F2RL2(1), MAPK8(1), MYEF2(1), PLD1(1), PLD2(1), PTK2(1), RASAL1(6), SRC(4), TEC(1), VAV1(2)	11900969	26	25	24	11	3	7	7	5	4	0	0.21	0.82
154	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	80	ANPEP(2), CD19(2), CD1B(2), CD1C(2), CD22(3), CD34(1), CD38(2), CD3E(2), CD4(1), CD44(1), CD5(1), CD55(1), CD8A(1), CD9(1), CR1(2), CR2(1), CSF1(1), CSF1R(1), CSF3(1), CSF3R(1), DNTT(2), EPOR(1), FCGR1A(2), FLT3(2), GP5(1), HLA-DRA(1), HLA-DRB1(1), IL11RA(1), IL2RA(2), IL4R(2), IL5RA(1), IL6R(1), IL7R(3), ITGA1(1), ITGA2B(4), ITGA3(2), ITGA4(3), ITGA5(1), ITGA6(1), KIT(7), KITLG(1), MME(2), MS4A1(2), TFRC(3), THPO(1), TNF(1), TPO(4)	35829400	82	66	82	18	12	12	31	20	7	0	0.21	0.82
155	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	142	CBLB(1), CBLC(3), CNTFR(2), CREBBP(7), CSF2RB(3), CSF3(1), CSF3R(1), EP300(1), EPOR(1), GH2(1), GHR(1), GRB2(2), IFNA1(2), IFNA13(2), IFNA5(1), IFNA8(1), IFNAR2(1), IFNB1(1), IL10RA(1), IL10RB(1), IL11RA(1), IL12RB2(3), IL13(2), IL19(1), IL20RA(2), IL21R(3), IL22(1), IL24(1), IL28A(1), IL28RA(1), IL2RA(2), IL2RB(1), IL4R(2), IL5RA(1), IL6R(1), IL7R(3), IRF9(1), JAK2(2), JAK3(3), LEPR(1), LIFR(2), OSMR(2), PIAS2(1), PIK3CA(2), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R5(1), PRLR(2), SOCS2(1), SOCS4(1), SOCS5(1), SOS1(3), SOS2(1), SPRED1(1), SPRED2(2), SPRY1(1), SPRY2(1), SPRY4(1), STAM(1), STAM2(1), STAT1(2), STAT2(1), STAT3(1), STAT4(1), STAT5A(2), STAT5B(3), STAT6(2), TPO(4), TYK2(2)	61397096	117	96	117	36	12	14	40	36	15	0	0.21	0.82
156	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(4), GNAS(3)	2545359	7	7	6	0	4	0	1	0	2	0	0.21	0.82
157	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	161	ADCY1(4), ADCY2(6), ADCY3(2), ADCY4(1), ADCY7(1), ADCY9(5), ADORA2B(2), ADRA1A(1), ADRB2(1), ATP2A1(2), ATP2A2(1), ATP2A3(1), ATP2B1(1), ATP2B2(4), ATP2B3(1), ATP2B4(2), AVPR1B(3), BDKRB1(4), BDKRB2(3), CACNA1A(5), CACNA1B(1), CACNA1C(9), CACNA1D(6), CACNA1E(4), CACNA1F(4), CACNA1G(3), CACNA1S(5), CALM3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMK4(3), CCKBR(1), CD38(2), CHRM2(4), CHRM3(3), CHRM5(1), CHRNA7(1), CYSLTR1(1), DRD1(2), EDNRA(1), EGFR(7), ERBB2(4), ERBB3(2), F2R(2), GNA11(1), GNA14(2), GNAL(1), GNAS(3), GRIN2A(3), GRIN2C(1), GRIN2D(3), GRM1(4), GRM5(2), GRPR(1), HRH1(1), HTR2A(3), HTR2C(4), HTR4(2), HTR5A(2), HTR6(1), ITPKB(4), ITPR1(3), ITPR2(5), ITPR3(3), LHCGR(3), MYLK(6), MYLK2(1), NOS1(2), NOS3(2), P2RX1(1), P2RX5(1), PDE1A(1), PDE1B(1), PDGFRA(3), PDGFRB(3), PHKA1(3), PHKA2(2), PLCB1(4), PLCB2(4), PLCB3(2), PLCB4(1), PLCD4(2), PLCE1(1), PLCG2(1), PLCZ1(1), PPP3CC(1), PRKACG(1), PRKCA(1), PRKCG(1), PTGFR(3), PTK2B(1), RYR1(11), RYR2(15), RYR3(4), SLC25A4(1), SLC25A5(1), SLC8A1(2), SLC8A3(1), SPHK1(1), TACR1(1), TACR2(2), TACR3(1), TRPC1(2), VDAC2(1)	112277705	266	148	263	71	39	35	90	72	30	0	0.21	0.82
158	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	41	ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ADHFE1(1), AGPAT3(1), AGPAT4(2), AKR1B1(3), ALDH1A1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), DGKA(3), DGKB(3), DGKD(2), DGKE(1), DGKH(3), GLB1(2), LCT(6), LIPG(1), LPL(1), PNLIP(2), PNLIPRP1(1), PNLIPRP2(1), PPAP2A(1)	19782752	43	38	43	11	2	9	15	12	5	0	0.21	0.82
159	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	ABP1(2), ACAT1(2), ACAT2(1), ALDH1A1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), AOC2(4), AOC3(1), AOX1(4), CAT(1), CYP1A1(2), CYP1A2(1), CYP2A13(3), CYP2A6(2), CYP2A7(3), CYP2B6(1), CYP2C18(2), CYP2C19(4), CYP2C9(1), CYP2E1(1), CYP2F1(1), CYP2J2(1), DDC(1), ECHS1(1), EHHADH(2), HAAO(1), HADHA(1), KMO(2), MAOA(2), MAOB(1), WARS(1)	24176324	54	48	54	18	2	8	20	16	8	0	0.21	0.82
160	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(3), F2R(2), F5(3), F7(1), FGA(3), FGB(2), PROC(1), PROS1(1), SERPINC1(1)	7103688	17	15	17	3	3	4	3	6	1	0	0.22	0.82
161	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	22	GPLD1(1), PGAP1(5), PIGA(1), PIGB(2), PIGG(3), PIGH(1), PIGK(1), PIGO(3), PIGX(1), PIGZ(2)	10098155	20	19	19	9	3	6	0	7	4	0	0.22	0.82
162	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	CDKN1A(1), ELK1(2), GRB2(2), NGFR(1), NTRK1(4), PIK3CA(2), SHC1(1), SOS1(3)	6211558	16	14	16	8	3	2	10	1	0	0	0.22	0.82
163	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2B(2), ADORA3(2), P2RY2(2), P2RY6(1)	2497606	7	7	7	2	1	1	2	3	0	0	0.22	0.82
164	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(7), EP300(1), NCOA3(4), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RARA(1), RXRA(2)	8841720	18	18	18	2	1	1	3	7	6	0	0.22	0.82
165	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	49	ACTG1(2), APAF1(2), BID(1), BIRC3(2), CASP2(1), CASP6(1), CASP7(1), CASP9(1), CHUK(1), DAXX(1), FADD(1), GSN(1), LMNA(4), LMNB1(1), MAP3K1(1), MAP3K14(1), MAP3K5(2), MAPK8(1), NFKB1(1), NUMA1(4), PAK2(1), PRKDC(8), PTK2(1), RASA1(1), RB1(9), RELA(1), SPTAN1(5), TNF(1), TNFRSF1A(1), TRAF1(4), TRAF2(1)	29492798	63	54	63	12	6	13	16	15	13	0	0.22	0.82
166	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(2), F2(3), F2R(2), FGA(3), FGB(2), PLAU(2), SERPINE1(1)	6161353	16	14	16	2	3	4	5	4	0	0	0.23	0.85
167	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP7(1), HMGB1(1), TOP2A(6), TOP2B(1)	4097459	9	9	9	2	0	0	3	1	5	0	0.23	0.85
168	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(1), HLA-DRA(1), HLA-DRB1(1)	1108511	3	3	3	0	0	1	1	0	1	0	0.24	0.85
169	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), ATIC(2), GART(3), MTFMT(3), MTHFD1(2), MTHFD1L(3), SHMT1(1), SHMT2(1)	8280255	18	18	17	2	1	4	7	2	4	0	0.24	0.85
170	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(8), CDH1(2), CREBBP(7), EP300(1), MAP3K7(3), SKIL(1), TGFBR2(3)	11613959	25	22	25	6	1	5	4	10	5	0	0.24	0.85
171	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	27	ATG3(3), BECN1(1), IFNA1(2), IFNA13(2), IFNA5(1), IFNA8(1), PIK3R4(4), PRKAA2(2), ULK2(1)	8413746	17	17	17	4	0	2	8	6	1	0	0.24	0.85
172	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT2(1), B4GALT5(1), FUT8(1), ST3GAL2(2), ST3GAL3(3)	3374528	8	8	8	0	3	1	2	2	0	0	0.24	0.85
173	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	15	ALOX12(1), ALOX15(1), ALOX15B(2), ALOX5(1), ALOX5AP(1), PLA2G6(1), PTGDS(1), PTGIS(3), PTGS1(1), PTGS2(1), TBXAS1(2)	5949100	15	14	15	0	1	5	4	2	3	0	0.24	0.85
174	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(4), GNAS(3), PPP2CA(2), PRKAA2(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	6308374	14	14	13	0	5	0	2	4	3	0	0.24	0.85
175	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	7	MTMR1(2), MTMR6(2), NFS1(1), TPK1(1)	2805444	6	6	6	0	2	1	0	2	1	0	0.24	0.85
176	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CHUK(1), ELK1(2), FOS(1), IKBKB(1), IRAK1(2), MAP2K3(1), MAP2K4(1), MAP2K6(1), MAP3K1(1), MAP3K14(1), MAP3K7(3), MAPK14(1), MAPK8(1), NFKB1(1), PPARA(1), RELA(1), TIRAP(1), TLR3(2), TLR4(4), TLR6(2), TLR7(1), TRAF6(2)	15409974	32	29	32	3	6	7	9	9	1	0	0.24	0.85
177	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(2), HLA-DRA(1), HLA-DRB1(1), IL12RB2(3), IL18R1(2), IL2RA(2), IL4R(2)	5847740	13	12	13	0	0	6	3	3	1	0	0.25	0.85
178	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	16	AKR1B1(3), UGDH(2), UGT1A10(2), UGT1A3(1), UGT1A5(1), UGT1A7(1), UGT1A8(2), UGT1A9(2), UGT2B4(1)	6935112	15	15	15	4	1	4	2	5	3	0	0.25	0.85
179	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	BRAF(2), DAG1(3), EGFR(7), EPHB2(1), GRB2(2), ITPKB(4), ITPR1(3), ITPR2(5), ITPR3(3), KCNJ9(1), PIK3CB(1), PITX2(1), PLCB1(4), PLCB2(4), PLCB3(2), PLCB4(1), SHC1(1), SOS1(3), SOS2(1), SRC(4), STAT3(1)	25170037	54	49	52	18	3	7	23	16	5	0	0.25	0.85
180	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(1), EGFR(7), HGS(1), TF(1), TFRC(3)	5695943	13	13	13	6	1	1	4	6	1	0	0.25	0.85
181	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABP1(2), ACADM(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), AOC2(4), AOC3(1), DPYD(3), DPYS(1), ECHS1(1), EHHADH(2), GAD1(1), GAD2(1), HADHA(1), SMS(1), UPB1(1)	11796437	25	25	25	6	2	1	7	8	7	0	0.25	0.85
182	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(3), CYP11A1(1), CYP11B2(1), HSD3B1(2), HSD3B2(1)	3066758	8	8	8	5	0	1	4	2	1	0	0.26	0.86
183	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(1), CALM3(1), GNAS(3), NFKB1(1), NOS3(2), NPPA(1), NR3C1(2), PIK3CA(2), PIK3R1(1), RELA(1)	7079993	15	15	14	7	1	1	5	4	4	0	0.26	0.86
184	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL1(1), FOSL2(2), IFNAR2(1), IFNB1(1), MAPK8(1), NFKB1(1), RELA(1), TRAF6(2)	4880303	11	11	11	1	2	3	2	4	0	0	0.26	0.86
185	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(2), IFNB1(1), IL13(2), IL16(3), IL8(1), TNF(1)	4465560	10	10	10	3	0	1	3	6	0	0	0.26	0.86
186	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), UGDH(2), UXS1(2)	2266027	5	5	4	0	0	1	2	1	1	0	0.26	0.87
187	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	14	CHUK(1), CREBBP(7), EP300(1), FADD(1), HDAC3(2), IKBKB(1), NFKB1(1), RELA(1), TNF(1), TNFRSF1A(1), TRAF6(2)	9773832	19	19	19	3	2	4	4	4	5	0	0.26	0.87
188	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	BDKRB2(3), CALM3(1), CHRNA1(1), FLT1(2), FLT4(3), KDR(1), NOS3(2), PDE2A(2), PDE3A(4), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKG1(1), RYR2(15)	16793594	38	35	38	10	3	4	14	14	3	0	0.27	0.87
189	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP2(1), ACPP(2), ALPL(2), ALPP(2), CYP1A1(2), CYP1A2(1), CYP2A13(3), CYP2A6(2), CYP2A7(3), CYP2B6(1), CYP2C18(2), CYP2C19(4), CYP2C9(1), CYP2E1(1), CYP2F1(1), CYP2J2(1)	12324532	29	27	29	10	0	7	12	8	2	0	0.27	0.87
190	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	GRB2(2), IL4R(2), IRS1(6), JAK3(3), SHC1(1), STAT6(2)	6074163	16	13	16	4	2	6	5	1	2	0	0.27	0.87
191	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL2(2), ST8SIA1(2)	2333143	6	6	6	0	1	1	3	1	0	0	0.27	0.87
192	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	15	GATA3(1), IL13(2), MAP2K3(1), MAPK14(1), NFATC1(1), NFATC2(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	4365219	10	10	10	5	3	1	0	6	0	0	0.28	0.89
193	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD3E(2), CD4(1), CXCR3(2), IL12RB2(3), JAK2(2), STAT4(1), TYK2(2)	6293247	13	13	13	2	1	3	4	4	1	0	0.28	0.89
194	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(2), CA1(1), CA12(1), CA14(3), CA4(2), CA5A(1), CA6(1), CA9(2), CPS1(4), GLS(1), GLS2(1), HAL(1)	8489310	20	17	20	10	1	2	9	4	4	0	0.28	0.89
195	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(2), GSS(3), IL8(1), NFKB1(1), NOX1(1), RELA(1), TNF(1), XDH(1)	4567299	11	11	11	2	1	1	7	1	1	0	0.28	0.89
196	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABP1(2), ACADM(1), ACADSB(2), ALDH1A1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), AOC2(4), AOC3(1), DPYD(3), DPYS(1), ECHS1(1), EHHADH(2), GAD1(1), GAD2(1), HADHA(1), SMS(1), UPB1(1)	12839218	27	26	27	8	2	3	8	7	7	0	0.28	0.89
197	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	56	ABO(1), B3GALT1(1), B3GALT2(2), B3GALT4(2), B3GNT2(1), B3GNT4(2), B3GNT5(1), B4GALT2(1), FUT1(1), FUT9(1), GCNT2(2), PIGA(1), PIGB(2), PIGG(3), PIGH(1), PIGK(1), PIGO(3), PIGX(1), PIGZ(2), ST3GAL2(2), ST3GAL3(3), ST3GAL6(1), ST6GALNAC3(2), ST8SIA1(2), ST8SIA5(1)	19535253	40	35	40	11	9	10	8	7	6	0	0.29	0.89
198	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(3), EIF2AK4(1), EIF2B5(4), EIF2S1(1), GSK3B(1)	4970970	10	10	10	1	1	1	5	2	1	0	0.29	0.89
199	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	30	CHUK(1), IFNA1(2), IFNB1(1), IKBKB(1), IL1RN(1), IRAK1(2), IRAK2(1), IRAK3(2), MAP2K3(1), MAP2K6(1), MAP3K1(1), MAP3K14(1), MAP3K7(3), MAPK14(1), MAPK8(1), NFKB1(1), RELA(1), TNF(1), TRAF6(2)	12578171	25	24	25	4	5	7	6	7	0	0	0.29	0.89
200	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2)	689704	2	2	2	0	0	0	1	0	1	0	0.29	0.89
201	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(1), FUT9(1), HEXA(2), HEXB(1), ST3GAL2(2), ST8SIA1(2)	4082655	9	9	9	1	2	1	3	3	0	0	0.29	0.89
202	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	DOCK1(4), ELK1(2), FOS(1), GRB2(2), HGF(2), ITGA1(1), MAP4K1(1), MAPK8(1), MET(4), PIK3CA(2), PIK3R1(1), PTEN(2), PTK2(1), PTK2B(1), PXN(5), RASA1(1), SOS1(3), SRC(4), STAT3(1)	19305711	39	37	37	11	3	4	21	4	7	0	0.30	0.89
203	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(2), ALDH3A1(1), AOC2(4), AOC3(1), DDC(1), EPX(2), LPO(1), MAOA(2), MAOB(1), TAT(2), TPO(4)	9489878	21	20	21	5	2	1	7	6	5	0	0.30	0.89
204	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(3), COL4A2(1), COL4A3(1), COL4A4(3), COL4A5(4), COL4A6(5), F2(3), F2R(2), F5(3), F8(4), F9(1), FGA(3), FGB(2), KLKB1(2), PROC(1), PROS1(1), SERPINC1(1)	19578286	40	35	40	11	5	11	11	10	3	0	0.30	0.89
205	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(4), CAP1(1), GNAS(3), MYT1(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RPS6KA1(1), SRC(4)	8217829	18	18	15	3	5	0	6	5	2	0	0.30	0.89
206	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(3), ABCB11(3), ABCB4(3), ABCC1(5)	6479479	14	13	14	5	3	0	3	6	2	0	0.30	0.89
207	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(2), BIRC3(2), CASP1(2), CASP2(1), CASP4(1), CASP6(1), CASP7(1), CASP9(1), LMNA(4), LMNB1(1), PRF1(2)	8247645	18	17	18	5	2	2	5	8	1	0	0.30	0.89
208	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA2(2), ANXA5(1), ANXA6(1), CYP11A1(1), EDNRA(1), PLA2G4A(1), PTGDR(1), PTGDS(1), PTGFR(3), PTGIS(3), PTGS1(1), PTGS2(1), TBXAS1(2)	9121645	19	19	19	4	4	2	7	2	4	0	0.30	0.89
209	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	27	CD4(1), CSF1(1), CSF3(1), HLA-DRA(1), HLA-DRB1(1), IFNA1(2), IFNB1(1), IL13(2), IL8(1), TNF(1)	5803202	12	12	12	2	1	2	2	5	2	0	0.30	0.89
210	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	23	AKR1B1(3), B4GALT2(1), G6PC(1), GAA(2), GALE(1), GANAB(1), GLB1(2), HK1(1), HK2(1), HK3(3), LCT(6), MGAM(5), PFKP(2)	13582242	29	27	29	6	4	5	9	7	4	0	0.31	0.90
211	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ADCY1(4), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY9(5), ADRA1A(1), ADRB2(1), ANXA6(1), ATP1A4(1), ATP1B1(1), ATP2A2(1), ATP2A3(1), ATP2B1(1), ATP2B2(4), ATP2B3(1), CACNA1A(5), CACNA1B(1), CACNA1C(9), CACNA1D(6), CACNA1E(4), CACNA1S(5), CACNB1(1), CALM3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMK4(3), CASQ1(1), CHRM2(4), CHRM3(3), CHRM5(1), FXYD2(1), GJA1(2), GJA5(1), GJB4(1), GJB5(1), GJB6(1), GNA11(1), GNAI2(1), GNB2(2), GNG13(1), GRK5(1), GRK6(1), ITPR1(3), ITPR2(5), ITPR3(3), KCNB1(1), MIB1(5), PLCB3(2), PRKAR2A(1), PRKAR2B(1), PRKCA(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCQ(3), PRKCZ(2), PRKD1(2), RGS18(2), RGS4(2), RGS7(4), RGS9(2), RYR1(11), RYR2(15), RYR3(4), SLC8A1(2), SLC8A3(1), USP5(1), YWHAB(1)	80751388	174	122	173	47	38	16	57	44	19	0	0.32	0.92
212	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(2), CPEB1(1), EGFR(7), ERBB2(4), ETS1(1), ETS2(1), ETV6(1), ETV7(1), FMN2(3), GRB2(2), KRAS(2), NOTCH2(4), NOTCH3(4), NOTCH4(5), PIWIL1(1), PIWIL3(3), SOS1(3), SOS2(1), SPIRE1(1)	20900550	47	40	45	21	4	6	26	9	2	0	0.32	0.92
213	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CHN1(2), LIMK1(1), MAP3K1(1), MYL2(1), MYLK(6), NCF2(4), PDGFRA(3), PIK3CA(2), PIK3R1(1), PLD1(1), PPP1R12B(4), TRIO(2), VAV1(2)	15629999	30	29	30	9	3	2	9	14	2	0	0.32	0.92
214	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	38	APH1A(1), CREBBP(7), CTBP1(1), CTBP2(1), DLL4(1), DTX1(1), DTX2(1), DTX3L(2), DVL3(1), EP300(1), HDAC1(1), HES1(1), MAML1(2), MAML2(3), MAML3(1), NCOR2(1), NOTCH2(4), NOTCH3(4), NOTCH4(5), NUMB(2), NUMBL(2), PSENEN(1), PTCRA(2), RBPJL(2), SNW1(1)	24419214	49	45	49	14	10	6	13	14	6	0	0.32	0.92
215	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(2), GRM1(4), PLCB1(4), PPP2CA(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	6790287	15	14	15	4	2	1	7	4	1	0	0.32	0.92
216	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	CARD11(1), CBLB(1), CBLC(3), CD3E(2), CD4(1), CD8A(1), CHUK(1), FOS(1), GRB2(2), IKBKB(1), ITK(5), KRAS(2), LCK(1), LCP2(1), MAP3K14(1), NCK2(1), NFAT5(1), NFATC1(1), NFATC2(1), NFATC4(1), NFKB1(1), NRAS(2), PAK2(1), PAK3(5), PAK6(2), PAK7(1), PDCD1(1), PDK1(1), PIK3CA(2), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R5(1), PPP3CC(1), PRKCQ(3), PTPRC(3), RASGRP1(1), RHOA(2), SOS1(3), SOS2(1), TEC(1), TNF(1), VAV1(2), VAV2(4), VAV3(3), ZAP70(1)	42827290	79	72	77	32	6	11	33	20	9	0	0.32	0.92
217	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADM(1), ACADSB(2), ACADVL(2), ACAT1(2), ACAT2(1), ACOX1(2), ACSL1(2), ACSL3(2), ACSL4(1), ACSL6(1), ADH1B(1), ADH1C(1), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), CPT1A(2), CPT1B(2), CPT1C(1), CPT2(1), CYP4A11(4), CYP4A22(1), ECHS1(1), EHHADH(2), HADHA(1), HSD17B4(1)	21413911	44	38	43	11	2	8	17	8	9	0	0.33	0.92
218	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	GRB2(2), IARS(1), IL4R(2), INPP5D(4), JAK2(2), JAK3(3), PIK3CA(2), SERPINA4(2), SHC1(1), SOS1(3), SOS2(1), SRC(4), STAT6(2), TYK2(2)	15724973	31	29	29	12	3	5	16	4	3	0	0.33	0.92
219	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B2(1), EIF2B4(1), EIF2B5(4), EIF2S1(1), FLT1(2), FLT4(3), KDR(1), NOS3(2), PIK3CA(2), PIK3R1(1), PRKCA(1), PTK2(1), PXN(5), SHC1(1)	13990352	26	26	26	11	3	6	7	8	2	0	0.34	0.92
220	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1(2), ACVR1B(1), ACVR1C(2), ACVR2B(3), AMHR2(1), BMP2(1), BMP5(1), BMP6(1), BMPR1A(1), BMPR1B(1), BMPR2(3), CHRD(1), COMP(3), CREBBP(7), E2F5(1), EP300(1), INHBA(3), LTBP1(3), PITX2(1), PPP2CA(2), PPP2R1A(4), PPP2R2A(1), PPP2R2B(1), RBL1(1), RBL2(3), RHOA(2), RPS6KB2(1), SMAD1(1), SMAD7(1), SMURF1(1), TFDP1(2), TGFBR2(3), THBS1(2), THBS2(4), THBS3(3), THBS4(1), TNF(1), ZFYVE9(2)	42288370	73	65	72	21	9	11	22	16	15	0	0.34	0.92
221	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	GRB2(2), KLK2(1), NTRK1(4), PIK3CA(2), PIK3R1(1), PRKCA(1), SHC1(1), SOS1(3)	6760845	15	13	15	8	3	3	7	1	1	0	0.34	0.92
222	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(4), ITGAV(2), PDGFRA(3), PIK3CA(2), PIK3R1(1), PLCB1(4), PRKCA(1), PTK2(1), SPHK1(1), SRC(4)	11803893	23	22	21	9	5	3	8	5	2	0	0.34	0.92
223	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(2), HLA-DRA(1), HLA-DRB1(1)	1374193	4	3	4	2	0	1	1	1	1	0	0.34	0.92
224	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	51	ADH1B(1), ADH1C(1), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), AGK(1), AGPAT3(1), AGPAT4(2), AGPAT6(1), AKR1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), DGKA(3), DGKB(3), DGKD(2), DGKE(1), DGKH(3), DGKI(1), GK2(2), GLB1(2), GPAM(1), LCT(6), LIPG(1), LPL(1), PNLIP(2), PNLIPRP1(1), PNLIPRP2(1), PPAP2A(1)	24462409	50	43	50	10	3	9	19	13	6	0	0.34	0.92
225	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(1), EPX(2), LPO(1), SHMT1(1), SHMT2(1), TPO(4)	4986774	11	11	11	3	3	0	4	2	2	0	0.35	0.92
226	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	16	ACE(3), ACE2(2), AGTR2(2), ANPEP(2), CTSA(1), CTSG(1), LNPEP(2), MAS1(1), MME(2)	9036210	16	16	16	5	2	3	5	5	1	0	0.35	0.92
227	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(2), ASRGL1(1), CA1(1), CA12(1), CA14(3), CA4(2), CA5A(1), CA6(1), CA9(2), CPS1(4), GLS(1), GLS2(1), HAL(1)	9435780	21	18	21	11	1	2	10	4	4	0	0.35	0.92
228	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	FUT1(1), FUT9(1), HEXA(2), HEXB(1), ST3GAL2(2), ST8SIA1(2)	4373885	9	9	9	1	2	1	3	3	0	0	0.35	0.92
229	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGTR2(2), COL4A1(3), COL4A2(1), COL4A3(1), COL4A4(3), COL4A5(4), COL4A6(5)	11212233	21	20	21	6	3	6	5	5	2	0	0.35	0.92
230	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(1), EPX(2), LPO(1), SHMT1(1), SHMT2(1), TPO(4)	4996138	11	11	11	3	3	0	4	2	2	0	0.35	0.92
231	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(2), CCNA2(1), CDK2(1), CDKN1B(1), E2F2(1), PRB1(1)	3550246	7	7	7	6	1	2	1	3	0	0	0.35	0.92
232	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(1), CD80(1), HLA-DRA(1), HLA-DRB1(1)	1858767	4	4	4	0	0	1	1	1	1	0	0.36	0.92
233	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	B4GALT2(1), B4GALT5(1), DPAGT1(1), DPM1(1), FUT8(1), MAN1A1(1), MAN1B1(1), MGAT1(2), MGAT4B(1), MGAT5(3), RPN1(2), RPN2(1)	8068818	16	16	16	4	3	1	4	5	3	0	0.36	0.92
234	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	AGTR2(2), CALM3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), F2(3), GNA11(1), GRB2(2), JAK2(2), MAPK14(1), MAPK8(1), MYLK(6), PRKCA(1), PTK2B(1), SHC1(1), SOS1(3), STAT1(2), STAT3(1), STAT5A(2)	18089105	34	33	34	9	6	3	14	7	4	0	0.36	0.92
235	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(3), COL4A2(1), COL4A3(1), COL4A4(3), COL4A5(4), COL4A6(5), SLC23A1(1), SLC23A2(2), SLC2A1(1), SLC2A3(1)	10865339	22	21	22	6	2	6	8	4	2	0	0.36	0.92
236	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(4), ADRB2(1), GNAS(3), PLCE1(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	5857361	12	12	11	2	5	0	1	3	3	0	0.36	0.92
237	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	34	ACTN2(3), ACTN3(2), DMD(6), MYBPC1(3), MYBPC2(4), MYBPC3(3), MYH3(4), MYH7(3), MYH8(3), MYL2(1), MYL4(3), MYOM1(4), NEB(7), TNNT1(1), TPM2(1), TTN(72), VIM(2)	59289691	122	90	122	31	20	15	39	34	14	0	0.36	0.92
238	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHB1(4), ITGA1(1), L1CAM(5), LYN(1), SELP(3)	7046462	14	13	14	6	3	2	4	3	2	0	0.36	0.92
239	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD3E(2), CD4(1)	1283778	3	3	3	1	0	0	3	0	0	0	0.36	0.92
240	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(1), ACADVL(2), ACSL1(2), ACSL3(2), ACSL4(1), CPT1A(2), CPT2(1), EHHADH(2), HADHA(1), SCP2(1)	7381905	15	14	15	3	1	3	7	1	3	0	0.37	0.92
241	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	22	ALDOC(1), MDH2(1), ME1(2), ME3(1), PGK1(2), PGK2(1), PKLR(1), RPIA(1), TKT(2), TKTL1(5), TKTL2(1)	8462158	18	18	18	3	2	3	8	3	2	0	0.37	0.92
242	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	GTF2B(1), GTF2E1(1), HDAC3(2), NCOA1(2), NCOA2(1), NCOA3(4), NCOR2(1), RARA(1), RXRA(2), TBP(4)	10125474	19	19	17	2	1	1	5	3	9	0	0.37	0.92
243	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(2), CASP1(2), CASP7(1), INSR(6), MAGI1(2), MAGI2(4), RERE(3)	10127031	20	20	20	3	4	2	7	6	1	0	0.37	0.92
244	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	EGFR(7), GRB2(2), PTPRB(1), RASA1(1), SHC1(1), SOS1(3), SPRY1(1), SPRY2(1), SPRY4(1), SRC(4)	10849909	22	22	20	8	2	2	13	4	1	0	0.37	0.92
245	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(7), EP300(1), LPL(1), NCOA1(2), NCOA2(1), RXRA(2)	8061660	14	14	14	2	0	2	2	5	5	0	0.37	0.92
246	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(2), CD4(1), HLA-DRA(1), HLA-DRB1(1), IL5RA(1)	2491679	6	5	6	0	1	1	2	1	1	0	0.37	0.92
247	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	14	B3GAT1(3), B3GAT2(1), B3GAT3(1), CHPF(1), DSE(1), UST(2), XYLT1(4)	5385313	13	12	13	2	4	3	4	1	1	0	0.37	0.92
248	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	25	ALDOC(1), G6PD(4), GPI(2), H6PD(1), PFKP(2), PGD(1), PGLS(1), PRPS1L1(2), RPIA(1), TKT(2), TKTL1(5), TKTL2(1)	9962601	23	21	23	3	3	6	10	2	2	0	0.38	0.92
249	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(1), ACAT1(2), ECHS1(1), HADHA(1)	2304868	5	4	5	1	1	1	2	0	1	0	0.38	0.92
250	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(1), HADHA(1), HSD17B4(1), MECR(2), PPT1(1)	3813499	7	7	7	2	2	0	2	2	1	0	0.38	0.92
251	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGFR(7), MAP3K1(1), MAPK14(1), NCOR2(1), RARA(1), RXRA(2)	6496514	13	13	13	5	1	1	3	5	3	0	0.38	0.92
252	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	11	COASY(1), DPYD(3), DPYS(1), ENPP1(2), ENPP3(2), PANK3(1), UPB1(1)	5535166	11	11	11	3	1	0	4	2	4	0	0.38	0.92
253	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	CHRNB1(1), MUSK(2), PIK3CA(2), PIK3R1(1), PTK2(1), PTK2B(1), RAPSN(1), SRC(4), TERT(1)	6721371	14	14	12	9	0	2	8	2	2	0	0.38	0.92
254	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST3A1(1), XYLT1(4)	2478547	6	6	6	2	2	1	2	1	0	0	0.39	0.92
255	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST3A1(1), XYLT1(4)	2478547	6	6	6	2	2	1	2	1	0	0	0.39	0.92
256	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), CYP2E1(1), NR1I3(1), PTGS1(1), PTGS2(1)	2412823	5	5	5	2	1	1	3	0	0	0	0.39	0.92
257	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), DUSP1(2), IKBKAP(1), IKBKB(1), MAP3K1(1), MAP3K14(1), NFKB1(1), RELA(1), TNFAIP3(4), TRAF6(2)	7958068	15	15	15	4	4	2	5	4	0	0	0.39	0.92
258	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(2), PIK3R1(1), PLCB1(4), PRKCA(1), VAV1(2)	5724666	10	10	10	4	1	2	2	4	1	0	0.39	0.92
259	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(7), EP300(1), PELP1(1), SRC(4)	6416863	13	12	11	2	0	1	5	3	4	0	0.39	0.92
260	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCR(1), FOS(1), GRB2(2), JAK2(2), MAP2K4(1), MAP3K1(1), MAPK8(1), PIK3CA(2), PIK3R1(1), SOS1(3), STAT1(2), STAT5A(2), STAT5B(3)	11655572	22	21	22	6	2	2	11	4	3	0	0.40	0.92
261	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	65	ADCY1(4), BRAF(2), CACNA1C(9), CALM3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMK4(3), CREBBP(7), EP300(1), GRIA1(1), GRIA2(2), GRIN2A(3), GRIN2B(3), GRIN2C(1), GRIN2D(3), GRM1(4), GRM5(2), ITPR1(3), ITPR2(5), ITPR3(3), KRAS(2), NRAS(2), PLCB1(4), PLCB2(4), PLCB3(2), PLCB4(1), PPP1R12A(2), PPP3CC(1), PRKACG(1), PRKCA(1), PRKCG(1), RPS6KA1(1), RPS6KA2(1)	42616889	84	69	81	27	14	10	24	25	11	0	0.40	0.92
262	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	63	ADAM10(1), ATP6AP1(4), ATP6V0A2(1), ATP6V0D1(1), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(1), ATP6V1F(1), CHUK(1), CSK(1), EGFR(7), F11R(2), IKBKB(1), IL8(1), JAM3(1), LYN(1), MAP2K4(1), MAP3K14(1), MAPK14(1), MAPK8(1), MAPK9(1), MET(4), NFKB1(1), NOD1(2), PLCG2(1), PTPRZ1(7), RELA(1), SRC(4), TCIRG1(3), TJP1(3)	30054630	58	54	55	14	5	8	18	20	7	0	0.40	0.92
263	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), PLCB1(4), PRKCA(1), RELA(1)	3696182	7	7	7	1	2	1	3	1	0	0	0.40	0.92
264	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), TAT(2), TYR(1)	2156312	4	4	4	3	0	1	1	2	0	0	0.40	0.92
265	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	BTK(1), GRB2(2), GSK3A(2), GSK3B(1), IARS(1), INPP5D(4), PDK1(1), PIK3CA(2), PTEN(2), RPS6KA1(1), RPS6KA2(1), SHC1(1), SOS1(3), SOS2(1), TEC(1), YWHAB(1), YWHAE(2), YWHAG(2)	15614212	29	29	29	12	3	4	16	3	3	0	0.40	0.92
266	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(1), CD8A(1), CSF1(1), CSF3(1), IL8(1)	2701009	5	5	5	2	2	0	1	1	1	0	0.41	0.92
267	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	BHMT(1), DNMT1(2), DNMT3A(3), DNMT3B(2), MARS(2), MARS2(3), MTFMT(3), TAT(2)	8969405	18	18	18	4	1	5	7	5	0	0	0.41	0.92
268	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	TAT(2)	1217953	2	2	2	1	0	1	0	1	0	0	0.41	0.92
269	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	FOSB(1), GRIA2(2)	1466129	3	3	3	2	0	0	0	2	1	0	0.41	0.92
270	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1)	703431	1	1	1	0	1	0	0	0	0	0	0.41	0.92
271	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	GLB1(2), HEXA(2), HEXB(1), LCT(6), NAGLU(1)	5833589	12	12	12	2	0	1	6	2	3	0	0.41	0.92
272	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	CDKN1B(1), GRB2(2), PDPK1(1), PIK3CA(2), PIK3R1(1), PTEN(2), PTK2(1), SHC1(1), SOS1(3)	7785917	14	14	14	10	0	3	7	1	3	0	0.41	0.92
273	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4A1(1), EIF4A2(2), EIF4EBP1(1), EIF4G2(1), EIF4G3(1), MKNK1(1), PDPK1(1), PIK3CA(2), PIK3R1(1), PPP2CA(2), PTEN(2), RPS6(1), TSC1(3), TSC2(2)	11251173	21	20	21	7	0	2	9	4	6	0	0.41	0.92
274	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	36	ABP1(2), AGXT(1), AGXT2(2), ALAS1(1), AOC2(4), AOC3(1), BHMT(1), CHDH(1), CHKA(1), CHKB(1), CPT1B(2), DMGDH(2), GARS(1), GLDC(2), MAOA(2), MAOB(1), PLCB2(4), PLCG2(1), PSPH(1), SHMT1(1), SHMT2(1), TARS(2)	17446160	35	33	35	12	3	3	10	10	9	0	0.41	0.92
275	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	69	BTK(1), GAB2(4), GRB2(2), IL13(2), INPP5D(4), KRAS(2), LCP2(1), LYN(1), MAP2K3(1), MAP2K4(1), MAP2K6(1), MAPK14(1), MAPK8(1), MAPK9(1), MS4A2(1), NRAS(2), PDK1(1), PIK3CA(2), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R5(1), PLA2G12A(1), PLA2G12B(1), PLA2G2F(1), PLA2G4A(1), PLA2G6(1), PLCG2(1), PRKCA(1), PRKCE(1), SOS1(3), SOS2(1), TNF(1), VAV1(2), VAV2(4), VAV3(3)	29873766	59	51	57	19	5	9	22	17	6	0	0.42	0.92
276	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(4), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY9(5), AKAP1(1), AKAP10(1), AKAP12(1), AKAP3(1), AKAP4(1), AKAP6(4), AKAP8(2), AKAP9(5), ARHGEF1(3), CALM3(1), CHMP1B(2), GNA11(1), GNA12(1), GNA14(2), GNAI2(1), GNAL(1), GNB2(2), GNG13(1), ITPR1(3), KRAS(2), NRAS(2), PALM2(1), PDE1A(1), PDE1B(1), PDE4A(2), PDE4C(1), PDE7B(1), PDE8A(1), PLCB3(2), PPP3CC(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCI(2), PRKCQ(3), PRKCZ(2), PRKD1(2), PRKD3(3), RHOA(2), RRAS(1), USP5(1)	50747341	94	77	91	25	21	12	23	26	12	0	0.42	0.92
277	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), ELK1(2), EPOR(1), FOS(1), GRB2(2), JAK2(2), MAPK8(1), SHC1(1), SOS1(3), STAT5A(2), STAT5B(3)	9180117	19	18	19	2	1	3	11	3	1	0	0.42	0.92
278	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), CYP2C19(4), CYP2C9(1), DHRS2(1), DHRS7(1), ECHS1(1), EHHADH(2), HADHA(1), MYST3(3), MYST4(5), YOD1(3)	13494562	28	26	28	6	0	3	7	11	7	0	0.42	0.92
279	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(1), EHHADH(2), HADHA(1)	2127357	4	4	4	1	0	0	3	0	1	0	0.42	0.92
280	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(2), GBA(1), LPO(1), TPO(4)	3614017	8	8	8	3	1	0	4	1	2	0	0.42	0.92
281	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(1), KHK(1), LCT(6), MPI(1), PYGM(3), TREH(1)	5978088	13	13	13	2	1	1	8	2	1	0	0.42	0.92
282	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GHR(1), GRB2(2), INSR(6), IRS1(6), JAK2(2), PIK3CA(2), PIK3R1(1), PRKCA(1), RPS6KA1(1), SHC1(1), SLC2A4(1), SOS1(3), SRF(1), STAT5A(2), STAT5B(3)	13986290	33	26	33	9	2	4	18	6	3	0	0.42	0.92
283	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), UGDH(2)	3569998	7	7	7	1	0	2	0	3	2	0	0.42	0.92
284	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	28	B4GALT5(1), GALNT1(3), GALNT10(1), GALNT12(1), GALNT13(2), GALNT14(3), GALNT2(1), GALNT3(1), GALNT4(1), GALNT6(2), GALNT8(2), GALNTL2(1), GALNTL5(1), GCNT4(2), OGT(2), ST3GAL2(2), WBSCR17(1)	14374411	27	26	26	7	4	4	9	7	3	0	0.42	0.92
285	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(1), AASS(2), KARS(1)	2175443	4	4	4	1	0	0	1	3	0	0	0.43	0.92
286	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), ACAT2(1), BDH1(1), HMGCS2(1), OXCT1(2)	3242833	7	6	7	3	0	1	3	2	1	0	0.43	0.92
287	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), FADS2(2), PLA2G12A(1), PLA2G12B(1), PLA2G2F(1), PLA2G4A(1), PLA2G6(1)	4448820	9	9	9	1	1	2	4	0	2	0	0.43	0.92
288	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	14	DBH(2), DDC(1), GAD1(1), GAD2(1), MAOA(2), PAH(3), SLC18A3(1)	5736161	11	11	11	7	1	0	4	3	3	0	0.43	0.92
289	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	BCR(1), ELK1(2), FOS(1), GRB2(2), LYN(1), MAP3K1(1), PAPPA(3), RPS6KA1(1), SHC1(1), SOS1(3), VAV1(2), VAV2(4), VAV3(3)	12610660	25	24	25	9	2	1	14	6	2	0	0.43	0.92
290	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(2), G6PD(4), GCLM(1), GSS(3), GSTA1(1), GSTA2(1), GSTM1(1), GSTM5(1), GSTO2(1), MGST1(1), MGST2(1), PGD(1)	7718240	18	15	18	5	0	5	9	3	1	0	0.43	0.92
291	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	BPNT1(1), GRB2(2), PDK1(1), PIK3CA(2), PTEN(2), PTK2B(1), RBL2(3), SHC1(1), SOS1(3)	8583775	16	16	16	8	1	2	10	2	1	0	0.44	0.92
292	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(4), APOBEC3A(1), APOBEC3B(1)	3322067	6	6	6	0	2	2	1	1	0	0	0.44	0.92
293	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	CASP9(1), CHUK(1), GHR(1), NFKB1(1), PDPK1(1), PIK3CA(2), PIK3R1(1), PPP2CA(2), RELA(1)	6104266	11	11	11	5	1	1	4	3	2	0	0.44	0.92
294	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	CDK2(1), CDKN1B(1), F2RL2(1), GADD45A(1), GRB2(2), GSK3A(2), GSK3B(1), INPPL1(1), IRS1(6), IRS4(5), MET(4), NOLC1(1), PAK2(1), PAK3(5), PAK6(2), PAK7(1), PARD3(2), PARD6A(1), PDK1(1), PIK3CA(2), PREX1(3), PTEN(2), PTK2(1), RPS6KA1(1), RPS6KA2(1), SHC1(1), SLC2A4(1), SOS1(3), SOS2(1), TSC1(3), TSC2(2), YWHAB(1), YWHAE(2), YWHAG(2)	31490586	65	56	65	20	6	11	29	11	8	0	0.44	0.92
295	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), ATIC(2), GART(3), MTHFD1(2), MTHFD1L(3), SHMT1(1), SHMT2(1)	8116034	15	15	14	2	1	3	5	2	4	0	0.45	0.92
296	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	26	DUSP1(2), GORASP1(2), MAP2K4(1), MAPK14(1), MAPK8(1), MAPK8IP1(1), MAPK9(1), MAPKAPK5(1), NFKB1(1), PIK3CA(2), PIK3R1(1), TRAF2(1), TRAF5(1), TRAF6(2)	11136168	18	18	18	7	4	4	3	4	3	0	0.45	0.92
297	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2)	1383611	2	2	2	0	1	0	0	1	0	0	0.45	0.92
298	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL4R(2), JAK2(2), TYK2(2)	4480421	8	8	8	3	0	2	0	5	1	0	0.45	0.92
299	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL4R(2), JAK2(2), TYK2(2)	4480421	8	8	8	3	0	2	0	5	1	0	0.45	0.92
300	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP2(1), ACP6(2), ACPP(2), ALPL(2), ALPP(2), CYP3A43(1), DHRS2(1), DHRS7(1), PON3(1)	7245219	13	13	13	4	0	5	2	2	4	0	0.45	0.92
301	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	122	BID(1), BRAF(2), CD244(1), GRB2(2), HLA-A(1), HLA-E(1), HLA-G(3), ICAM1(1), ICAM2(1), IFNA1(2), IFNA13(2), IFNA5(1), IFNA8(1), IFNAR2(1), IFNB1(1), ITGAL(3), ITGB2(2), KIR2DL1(1), KIR2DL3(2), KIR2DL4(2), KIR3DL1(2), KIR3DL2(1), KLRC2(2), KLRC3(1), KRAS(2), LCK(1), LCP2(1), MICB(1), NCR1(1), NCR2(1), NCR3(1), NFAT5(1), NFATC1(1), NFATC2(1), NFATC4(1), NRAS(2), PIK3CA(2), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R5(1), PLCG2(1), PPP3CC(1), PRF1(2), PRKCA(1), PRKCG(1), PTK2B(1), SH3BP2(1), SHC1(1), SHC4(2), SOS1(3), SOS2(1), TNF(1), TNFRSF10A(2), TNFRSF10D(1), TNFSF10(1), TYROBP(1), VAV1(2), VAV2(4), VAV3(3), ZAP70(1)	47079132	92	74	90	31	7	13	33	27	12	0	0.45	0.92
302	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), DUSP1(2), IKBKAP(1), IKBKB(1), MAP3K1(1), MAP3K14(1), NFKB1(1), RELA(1), TNFAIP3(4), TRAF1(4), TRAF2(1)	9722476	18	18	18	4	4	2	5	6	1	0	0.46	0.92
303	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	FUCA2(1), GBA(1), GLB1(2), HEXA(2), HEXB(1), HPSE(1), HPSE2(1), LCT(6), MAN2B1(3), MAN2B2(3), MAN2C1(1), MANBA(1), NAGLU(1), NEU1(1), NEU3(1), SPAM1(2)	13895063	28	26	28	9	1	4	10	9	4	0	0.46	0.92
304	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	42	ABCA1(5), ABCA10(2), ABCA12(7), ABCA13(5), ABCA3(4), ABCA4(4), ABCA5(2), ABCA6(3), ABCA8(2), ABCA9(4), ABCB1(3), ABCB11(3), ABCB4(3), ABCB5(3), ABCB6(1), ABCB7(2), ABCB8(2), ABCB9(1), ABCC1(5), ABCC10(4), ABCC11(1), ABCC12(2), ABCC2(1), ABCC4(1), ABCC5(2), ABCC6(1), ABCC8(1), ABCC9(2), ABCD2(2), ABCG1(2), ABCG4(2), CFTR(2)	49676141	84	76	84	17	14	14	29	20	7	0	0.46	0.92
305	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(2)	808930	2	2	2	1	0	0	2	0	0	0	0.46	0.92
306	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA4(1), PSMB1(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC3(4), RPN1(2), RPN2(1)	5964778	12	11	12	4	1	0	3	5	3	0	0.46	0.92
307	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	38	ATF1(3), BRAF(2), CREBBP(7), DAG1(3), EGR1(2), EGR4(1), ELK1(2), MAP2K4(1), MAPK8(1), MAPK8IP1(1), MAPK9(1), NTRK1(4), OPN1LW(1), PIK3CA(2), PIK3R1(1), SHC1(1), SRC(4)	19987430	37	34	35	14	5	4	12	10	6	0	0.46	0.92
308	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	46	AGPAT3(1), AGPAT4(2), CDS1(1), CHKA(1), CHKB(1), CPT1B(2), DGKA(3), DGKB(3), DGKD(2), DGKE(1), DGKH(3), GNPAT(4), GPD2(1), LCAT(2), LYPLA2(1), PAFAH2(2), PLA2G4A(1), PLA2G6(1), PLCB2(4), PLCG2(1), PPAP2A(1)	19968929	38	36	38	11	2	7	11	14	4	0	0.46	0.92
309	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ABP1(2), ADH1B(1), ADH1C(1), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), ALDH3A1(1), AOC2(4), AOC3(1), AOX1(4), DBH(2), DCT(2), DDC(1), ECH1(2), MAOA(2), MAOB(1), METTL6(1), MYST3(3), MYST4(5), PRMT5(2), PRMT8(3), TAT(2), TPO(4), TYR(1), WBSCR22(1)	25235022	50	43	50	15	4	4	13	21	8	0	0.46	0.92
310	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	BRAF(2), C7orf16(1), CACNA1A(5), GNA11(1), GNA12(1), GNAI2(1), GNAS(3), GRIA1(1), GRIA2(2), GRIA3(2), GRID2(2), GRM1(4), GRM5(2), GUCY1A3(1), GUCY2C(3), IGF1R(1), ITPR1(3), ITPR2(5), ITPR3(3), KRAS(2), LYN(1), NOS1(2), NOS3(2), NPR1(1), NPR2(2), NRAS(2), PLA2G12A(1), PLA2G12B(1), PLA2G2F(1), PLA2G4A(1), PLA2G6(1), PLCB1(4), PLCB2(4), PLCB3(2), PLCB4(1), PPP2CA(2), PPP2R1A(4), PPP2R2A(1), PPP2R2B(1), PRKCA(1), PRKCG(1), PRKG1(1), RYR1(11)	47091944	93	77	90	32	14	11	30	26	12	0	0.46	0.92
311	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	14	CHUK(1), MAP3K14(1), MAPK14(1), MAPK8(1), NFKB1(1), RELA(1), TNFSF13B(1), TRAF2(1), TRAF5(1), TRAF6(2)	6150369	11	11	11	3	2	3	4	2	0	0	0.47	0.92
312	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	103	ALG1(1), ALG10B(4), ALG11(2), ALG2(2), ALG8(2), ALG9(1), B3GNT2(1), B3GNT7(1), B4GALT2(1), B4GALT5(1), CHPF(1), CHST2(5), CHST6(1), DAD1(2), DPAGT1(1), EXT1(1), EXTL1(1), EXTL3(2), FUT8(1), GALNT1(3), GALNT10(1), GALNT12(1), GALNT13(2), GALNT14(3), GALNT2(1), GALNT3(1), GALNT4(1), GALNT6(2), GALNT8(2), GALNTL2(1), GALNTL5(1), GANAB(1), GCNT4(2), HS3ST3A1(1), HS3ST5(1), HS6ST3(1), MAN1A1(1), MAN1B1(1), MAN2A1(1), MGAT1(2), MGAT4B(1), MGAT5(3), MGAT5B(2), NDST1(1), NDST2(2), OGT(2), RPN1(2), RPN2(1), ST3GAL2(2), ST3GAL3(3), UST(2), WBSCR17(1), XYLT1(4)	46500228	87	74	86	22	18	12	24	20	13	0	0.47	0.92
313	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGFR(7), ELK1(2), FOS(1), GRB2(2), MAP2K4(1), MAP3K1(1), MAPK8(1), PIK3CA(2), PIK3R1(1), PRKCA(1), RASA1(1), SHC1(1), SOS1(3), SRF(1), STAT1(2), STAT3(1), STAT5A(2)	16382118	31	29	31	11	3	4	15	6	3	0	0.47	0.92
314	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), MST1R(3), TNF(1)	2405880	5	5	5	1	1	1	3	0	0	0	0.47	0.92
315	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	35	EEF1D(1), EEF1G(2), EEF2K(2), EIF1AX(1), EIF2AK2(2), EIF2AK3(3), EIF2B2(1), EIF2B4(1), EIF2B5(4), EIF2S1(1), EIF4A1(1), EIF4A2(2), EIF4EBP1(1), EIF4G3(1), EIF5B(1), ETF1(1), GSPT2(1), KIAA0664(1), PABPC1(2), PABPC3(4), PAIP1(1)	18064618	34	32	34	9	2	4	16	8	4	0	0.47	0.92
316	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(2), ALDH3A1(1), AOC2(4), AOC3(1), DDC(1), EPX(2), LPO(1), MAOA(2), MAOB(1), MYST3(3), MYST4(5), TAT(2), TPO(4)	15041308	29	28	29	8	2	2	8	10	7	0	0.47	0.92
317	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), CPS1(4), GLS(1)	3357119	6	6	6	5	0	1	4	0	1	0	0.47	0.92
318	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	30	AKR1B1(3), B4GALT2(1), G6PC(1), GAA(2), GALE(1), GLB1(2), HK1(1), HK2(1), HK3(3), LCT(6), MGAM(5), PFKP(2), RDH12(1), RDH13(1)	15620630	30	28	30	4	5	5	9	7	4	0	0.47	0.92
319	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), FOS(1), GRB2(2), JAK2(2), PIK3CA(2), PIK3R1(1), PRKCA(1), RASA1(1), SHC1(1), SOS1(3), STAT1(2), STAT3(1), STAT5A(2), STAT5B(3), THPO(1)	13126097	24	23	24	6	2	2	13	5	2	0	0.47	0.92
320	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	21	APC(8), DAG1(3), EPHB2(1), FOS(1), ITPKB(4), MAP2K4(1), MAPK8(1), MAPK8IP1(1), MAPK9(1)	10547207	21	18	21	7	2	3	5	8	3	0	0.48	0.92
321	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10B(4), ALG11(2), ALG2(2), ALG8(2), ALG9(1), B4GALT2(1), DAD1(2), DPAGT1(1), DPM1(1), FUT8(1), GANAB(1), MAN1A1(1), MAN1B1(1), MAN2A1(1), MGAT1(2), MGAT4B(1), MGAT5(3), MGAT5B(2), RPN1(2), RPN2(1)	17929942	33	31	33	9	6	2	8	9	8	0	0.48	0.92
322	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(2), C5(1), C6(2), C7(3), ICAM1(1), IL8(1), ITGA4(3), ITGAL(3), ITGB2(2), SELP(3), TNF(1)	10857154	22	19	22	6	2	3	5	8	4	0	0.48	0.92
323	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(5), CYP7A1(1), HMGCR(1), LCAT(2), LDLR(3), LPL(1), LRP1(7)	10976763	20	20	20	2	5	1	8	4	2	0	0.48	0.92
324	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	30	AASDH(5), AASDHPPT(1), AASS(2), ACAT1(2), ACAT2(1), ALDH1A1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), DLST(1), ECHS1(1), EHHADH(2), EHMT2(1), HADHA(1), PLOD1(1), PLOD2(1), PLOD3(3), SHMT1(1), SHMT2(1), TMLHE(1)	14859141	30	26	30	9	4	4	8	9	5	0	0.49	0.92
325	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(2), ACY1(1), ADC(2), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), AOC2(4), AOC3(1), ARG1(1), ASS1(1), CPS1(4), MAOA(2), MAOB(1), ODC1(1), OTC(1), SMS(1)	12834117	27	24	27	8	1	2	7	10	7	0	0.49	0.92
326	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	BRD4(1), CAP1(1), F2RL2(1), GRB2(2), GSK3A(2), GSK3B(1), INPPL1(1), IRS1(6), IRS4(5), LNPEP(2), PARD3(2), PARD6A(1), PDK1(1), PIK3CA(2), PIK3R1(1), PPYR1(2), PTEN(2), RPS6KA1(1), RPS6KA2(1), SHC1(1), SLC2A4(1), SORBS1(2), SOS1(3), SOS2(1), YWHAB(1), YWHAE(2), YWHAG(2)	24717861	48	43	48	17	5	8	20	7	8	0	0.49	0.92
327	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), ELK1(2), FOS(1), GRB2(2), IGF1R(1), IRS1(6), MAPK8(1), PIK3CA(2), PIK3R1(1), RASA1(1), SHC1(1), SOS1(3), SRF(1)	10427694	23	19	23	5	0	5	12	4	2	0	0.50	0.94
328	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	122	ACACB(4), BRAF(2), CALM3(1), CBLB(1), CBLC(3), EIF4EBP1(1), ELK1(2), G6PC(1), GRB2(2), GSK3B(1), GYS1(1), IKBKB(1), INPP5D(4), INSR(6), IRS1(6), IRS4(5), KRAS(2), LIPE(1), MAPK8(1), MAPK9(1), MKNK1(1), NRAS(2), PDE3A(4), PDPK1(1), PFKP(2), PHKA1(3), PHKA2(2), PIK3CA(2), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R5(1), PKLR(1), PPARGC1A(2), PPP1R3A(8), PPP1R3B(1), PRKAA2(2), PRKACG(1), PRKAG3(1), PRKAR2A(1), PRKAR2B(1), PRKCI(2), PRKCZ(2), PTPRF(4), PYGM(3), RAPGEF1(2), RPS6(1), RPS6KB2(1), SHC1(1), SHC4(2), SLC2A4(1), SOCS2(1), SOCS4(1), SORBS1(2), SOS1(3), SOS2(1), TRIP10(1), TSC1(3), TSC2(2)	63860487	122	96	120	28	12	17	50	29	14	0	0.50	0.94
329	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ADHFE1(1)	2609919	5	4	5	2	0	1	2	1	1	0	0.51	0.94
330	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	23	ATF1(3), CASP2(1), CHUK(1), IKBKB(1), MAP2K3(1), MAP2K4(1), MAP2K6(1), MAP3K1(1), MAP3K14(1), MAPK14(1), MAPK8(1), NFKB1(1), RELA(1), TNF(1), TNFRSF1A(1), TRAF2(1)	10059042	18	18	18	5	3	5	5	4	1	0	0.51	0.94
331	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	28	ANKRD6(3), APC(8), AXIN2(1), CTNNB1(2), DACT1(1), DKK2(2), DKK3(1), GSK3A(2), GSK3B(1), LRP1(7), MVP(2), WIF1(3)	16601452	33	31	33	9	6	1	12	9	5	0	0.51	0.94
332	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(2), IFNAR2(1), IFNB1(1), STAT1(2), STAT2(1), TYK2(2)	4634719	9	9	9	2	0	0	3	6	0	0	0.51	0.94
333	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	CHUK(1), DAXX(1), EGFR(7), ETS1(1), ETS2(1), FOS(1), HOXA7(1), IKBKB(1), MAP2K3(1), MAP2K4(1), MAP2K6(1), MAP3K1(1), MAP3K14(1), MAP3K5(2), MAPK14(1), MAPK8(1), NFKB1(1), PPP2CA(2), PRKCA(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCQ(3), RELA(1), TNF(1), TNFRSF1A(1), TRAF2(1)	21040124	37	37	37	12	5	7	9	9	7	0	0.51	0.94
334	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	29	AGPAT3(1), AGPAT4(2), AGPAT6(1), ENPP2(3), PAFAH1B3(1), PAFAH2(2), PLA2G12A(1), PLA2G12B(1), PLA2G2F(1), PLA2G4A(1), PLA2G6(1), PLD1(1), PLD2(1), PPAP2A(1)	10146738	18	18	18	4	3	4	5	5	1	0	0.51	0.94
335	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3E(2), IL2RA(2), TGFBR2(3), TGFBR3(2), TOB1(1)	4811608	10	9	10	4	1	1	6	1	1	0	0.51	0.94
336	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	ABP1(2), AOC2(4), AOC3(1), CES1(1), CES7(3), DDHD1(1), MYST3(3), MYST4(5), PLA1A(1)	11233304	21	20	21	6	1	2	5	7	6	0	0.52	0.95
337	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	10	FOS(1), FXYD2(1), KEAP1(1), MAPK14(1), MAPK8(1), PRKCA(1)	3597758	6	6	6	3	1	2	1	2	0	0	0.52	0.95
338	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(2), LPO(1), TPO(4), TYR(1)	4112949	8	8	8	3	1	0	4	2	1	0	0.53	0.95
339	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6R(1), JAK2(2), JAK3(3), PTPRU(1), SRC(4), STAT3(1)	6546962	12	12	10	4	2	1	6	1	2	0	0.53	0.95
340	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	77	AGL(1), AMY2A(1), ASCC3(5), ATP13A2(3), DDX18(1), DDX23(1), DDX4(1), DDX41(1), DDX47(1), DDX52(2), DDX54(2), DDX55(1), ENPP1(2), ENPP3(2), ENTPD7(1), EP400(2), ERCC2(1), G6PC(1), GAA(2), GBA(1), GPI(2), GYS1(1), HK1(1), HK2(1), HK3(3), IFIH1(1), MGAM(5), MOV10L1(2), NUDT5(1), PYGM(3), RAD54L(2), SETX(2), SI(10), SKIV2L2(1), SMARCA2(2), TREH(1), UGDH(2), UGT1A10(2), UGT1A3(1), UGT1A5(1), UGT1A7(1), UGT1A8(2), UGT1A9(2), UGT2A1(3), UGT2A3(1), UGT2B10(2), UGT2B11(1), UGT2B17(1), UGT2B4(1), UGT2B7(1), UXS1(2)	52294535	93	79	92	19	11	10	37	24	11	0	0.53	0.95
341	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25B(2), CDKN1A(1), NEK1(2)	3203612	5	5	5	1	2	0	2	1	0	0	0.53	0.95
342	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC6(1), CDC7(2), CDK2(1), DIAPH2(4), GMNN(1), MCM10(1), MCM2(2), MCM3(1), MCM4(2), MCM5(2), NACA(4), ORC1L(1), ORC4L(1), POLD1(1), POLD2(2), POLD3(1), POLE(2), POLE2(1), RFC1(2), RPA1(2), RPA2(1), RPA4(1), RPS27A(1), UBC(3)	21582663	40	38	40	7	4	3	16	10	7	0	0.53	0.95
343	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1B(1), ADH1C(1), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1)	5896766	11	10	11	3	0	2	2	4	3	0	0.53	0.96
344	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	GRB2(2), GSK3A(2), GSK3B(1), IL4R(2), IRS1(6), JAK3(3), MAP4K1(1), PDK1(1), PIK3CA(2), PIK3R1(1), SHC1(1), SOS1(3), SOS2(1), STAT6(2)	14548954	28	25	28	13	2	8	13	2	3	0	0.53	0.96
345	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	40	ALAS1(1), BLVRA(1), COX10(1), COX15(1), CPOX(1), FTH1(1), FTMT(1), HMBS(1), PPOX(2), UGT1A10(2), UGT1A3(1), UGT1A5(1), UGT1A7(1), UGT1A8(2), UGT1A9(2), UGT2A1(3), UGT2A3(1), UGT2B10(2), UGT2B11(1), UGT2B17(1), UGT2B4(1), UGT2B7(1)	17527352	29	28	28	11	2	6	8	6	7	0	0.54	0.96
346	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK2(2), JAK3(3), STAT3(1), TYK2(2)	4857650	8	8	8	4	1	1	1	3	2	0	0.54	0.96
347	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP1(1), ARHGAP5(2), ARHGAP6(1), ARHGEF1(3), ARHGEF11(2), ARPC1A(1), ARPC3(1), GSN(1), LIMK1(1), MYL2(1), MYLK(6), OPHN1(3), PIP5K1A(1), PPP1R12B(4), SRC(4), TLN1(1), VCL(2)	19646725	35	35	33	6	3	5	17	9	1	0	0.54	0.96
348	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	10	APC(8), BTRC(2), CTNNB1(2), GSK3B(1)	6851948	13	12	13	7	0	2	4	5	2	0	0.55	0.96
349	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), ACAT1(2), ACAT2(1), ECHS1(1), EHHADH(2), HADHA(1)	3733981	8	6	8	4	0	1	5	1	1	0	0.55	0.96
350	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	CALM3(1), CAMK4(3), CREBBP(7), F2(3), FGF2(1), GSK3B(1), MAPK14(1), MAPK8(1), MEF2C(1), MYH2(5), NFATC1(1), NFATC2(1), NFATC4(1), NPPA(1), PIK3CA(2), PIK3R1(1), PPP3CC(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	21165109	35	35	35	16	5	6	8	12	4	0	0.55	0.96
351	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ADHFE1(1), AKR1C4(1), ALDH1A1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), BAAT(1), CYP27A1(1), CYP7A1(1), SOAT2(2), SRD5A2(1)	10225508	18	17	18	8	0	4	5	6	3	0	0.55	0.96
352	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(2), RELN(8), VLDLR(1)	6388360	11	11	11	4	1	3	3	3	1	0	0.55	0.96
353	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	ABP1(2), ACAT1(2), ACAT2(1), AFMID(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), AOC2(4), AOC3(1), AOX1(4), CAT(1), CYP1A1(2), CYP1A2(1), CYP1B1(1), DDC(1), ECHS1(1), EHHADH(2), HAAO(1), HADHA(1), HSD17B4(1), INMT(1), KMO(2), MAOA(2), MAOB(1), METTL6(1), NFX1(1), OGDH(2), PRMT5(2), PRMT8(3), TPH2(1), WARS(1), WBSCR22(1)	26340135	50	44	50	15	3	6	19	14	8	0	0.55	0.96
354	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(2), BID(1), BIRC3(2), CASP6(1), CASP7(1), CASP9(1), CHUK(1), FADD(1), GAS2(1), LMNA(4), MAP3K14(1), NFKB1(1), RELA(1), SPTAN1(5), TNFRSF10A(2), TNFSF10(1), TRAF2(1)	14347455	27	27	27	8	4	4	11	7	1	0	0.55	0.96
355	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(5), ABCC2(1), BCHE(4), CES1(1), UGT1A10(2), UGT1A3(1), UGT1A5(1), UGT1A7(1), UGT1A8(2), UGT1A9(2)	10445971	20	19	20	8	1	2	8	7	2	0	0.55	0.96
356	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4A1(1), EIF4A2(2), EIF4EBP1(1), EIF4G2(1), EIF4G3(1), GHR(1), IRS1(6), MAPK14(1), MKNK1(1), PABPC1(2), PDPK1(1), PIK3CA(2), PIK3R1(1), PRKCA(1), PTEN(2)	12111501	24	20	24	8	2	3	9	6	4	0	0.56	0.96
357	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	46	ACCN1(3), ADCY4(1), CACNA1A(5), CACNA1B(1), GNAS(3), GNAT3(1), GNG13(1), GRM4(1), ITPR3(3), KCNB1(1), PDE1A(1), PLCB2(4), PRKACG(1), SCNN1B(1), SCNN1G(2), TAS1R1(1), TAS1R2(1), TAS2R1(3), TAS2R14(1), TAS2R16(1), TAS2R42(2), TAS2R43(1), TAS2R46(1), TAS2R50(2), TAS2R8(2), TAS2R9(1)	23131501	45	40	44	5	4	4	18	11	8	0	0.56	0.96
358	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	37	DAXX(1), DDIT3(2), ELK1(2), GRB2(2), MAP2K4(1), MAP2K6(1), MAP3K1(1), MAP3K5(2), MAP3K7(3), MAP3K9(1), MAPK14(1), MAPKAPK5(1), MEF2A(1), MEF2C(1), MEF2D(1), MKNK1(1), PLA2G4A(1), RPS6KA5(1), SHC1(1), STAT1(2), TRAF2(1)	16052954	28	28	28	8	1	5	11	5	6	0	0.56	0.96
359	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(3), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(1)	3880714	7	7	6	0	2	0	1	2	2	0	0.56	0.96
360	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ECHS1(1), EHHADH(2), HADHA(1)	5313211	9	9	9	4	0	2	3	2	2	0	0.56	0.96
361	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(3), F2R(2), ITGA1(1), PLA2G4A(1), PLCB1(4), PRKCA(1), PTGS1(1), PTK2(1), SRC(4), TBXAS1(2)	10854195	20	18	18	5	4	5	8	2	1	0	0.56	0.96
362	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BFAR(2), BRAF(2), SRC(4)	5129078	8	8	6	1	0	1	4	1	2	0	0.56	0.96
363	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	16	GLB1(2), HEXA(2), HEXB(1), HPSE(1), HPSE2(1), LCT(6), NAGLU(1), SPAM1(2)	8366998	16	15	16	4	0	2	6	5	3	0	0.57	0.96
364	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	23	ATM(5), BMPR1B(1), CDKN1B(1), EGR1(2), FSHR(4), INHA(1), LHCGR(3), MLH1(2), MSH5(2), NCOR1(1), PGR(1), PRLR(2), VDR(1), ZP2(1)	15367645	27	25	27	5	1	3	7	12	4	0	0.57	0.97
365	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	IL8(1)	667417	1	1	1	0	0	0	0	1	0	0	0.58	0.98
366	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), ELK1(2), FOS(1), GRB2(2), KLK2(1), MAPK8(1), NGFR(1), PIK3CA(2), PIK3R1(1), SHC1(1), SOS1(3)	8183579	16	14	16	5	0	4	8	3	1	0	0.58	0.98
367	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	9	ANPEP(2), FBL(1), LDHB(1), LDHC(1), MAPK14(1)	3783741	6	6	6	4	0	2	2	2	0	0	0.58	0.98
368	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(8), CREBBP(7), CTNNB1(2), EP300(1), GSK3B(1), HDAC1(1), LDB1(1), PITX2(1), TRRAP(3)	14006937	25	23	25	12	1	4	6	8	6	0	0.59	0.98
369	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(1), ACAD9(2), ADH1B(1), ADH1C(1), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), DHRS2(1), DHRS7(1), MYST3(3), MYST4(5)	10940233	19	18	19	6	0	4	4	5	6	0	0.59	0.98
370	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(1), CALCR(3), CALCRL(1), CD97(2), ELTD1(1), EMR1(1), EMR2(1), GHRHR(1), GLP2R(1), LPHN1(2), LPHN2(1), LPHN3(4), SCTR(1), VIPR2(1)	11697863	21	21	21	5	3	0	7	9	2	0	0.59	0.98
371	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(1), CRY1(2), CSNK1E(1), PER1(2)	3537733	6	6	6	2	0	1	2	2	1	0	0.60	0.98
372	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	INPP1(1), INPP4A(1), INPP4B(1), INPPL1(1), ITPKB(4), OCRL(1), PIK3C2A(3), PIK3C2B(3), PIK3CA(2), PIK3CB(1), PIK3CG(3), PLCB1(4), PLCB2(4), PLCB3(2), PLCB4(1), PLCG2(1)	19109252	33	31	33	11	3	8	11	10	1	0	0.60	0.98
373	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB27A(1), RAB4A(1), RAB9A(1)	1918809	3	3	3	1	1	1	1	0	0	0	0.60	0.98
374	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	29	ADCY3(2), ADRBK2(2), CALM3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CLCA1(2), CLCA2(2), CLCA4(1), CNGA3(5), CNGB1(2), GNAL(1), PRKACG(1), PRKG1(1)	13316774	24	24	24	3	3	2	10	5	4	0	0.60	0.98
375	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BIRC3(2), FADD(1), TNF(1), TNFRSF1A(1), TRAF2(1)	3425831	6	6	6	2	0	2	4	0	0	0	0.60	0.98
376	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ACAT2(1), ECHS1(1), EHHADH(2), HADHA(1)	3453829	7	5	7	2	0	1	4	1	1	0	0.60	0.98
377	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	103	ACTN2(3), ACTN3(2), ARHGAP5(2), CDH5(1), CLDN10(1), CLDN11(2), CLDN15(1), CLDN16(1), CLDN17(2), CLDN18(2), CLDN2(1), CLDN6(1), CLDN9(1), CTNNA1(2), CTNNA3(1), CTNNB1(2), F11R(2), GNAI2(1), GRLF1(6), ICAM1(1), ITGA4(3), ITGAL(3), ITGB2(2), ITK(5), JAM3(1), MAPK14(1), MLLT4(2), MMP2(1), MSN(2), MYL2(1), NCF2(4), NCF4(2), NOX1(1), NOX3(1), PECAM1(2), PIK3CA(2), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R5(1), PLCG2(1), PRKCA(1), PRKCG(1), PTK2(1), PTK2B(1), PXN(5), RASSF5(1), RHOA(2), RHOH(1), VAV1(2), VAV2(4), VAV3(3), VCL(2)	51867953	101	81	101	35	11	14	34	26	16	0	0.60	0.98
378	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	BTK(1), CARD11(1), CD19(2), CD22(3), CD79A(1), CHUK(1), CR2(1), FOS(1), GSK3B(1), IKBKB(1), INPP5D(4), KRAS(2), LILRB3(1), LYN(1), NFAT5(1), NFATC1(1), NFATC2(1), NFATC4(1), NFKB1(1), NRAS(2), PIK3CA(2), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R5(1), PLCG2(1), PPP3CC(1), RASGRP3(2), VAV1(2), VAV2(4), VAV3(3)	30508389	51	48	49	23	6	6	15	17	7	0	0.60	0.98
379	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), IL10RA(1), IL10RB(1), STAT1(2), STAT3(1), STAT5A(2), TNF(1)	5353975	9	9	9	4	1	1	5	1	1	0	0.60	0.98
380	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(3), CD44(1), CSF1(1), IL6R(1), SPN(1), TNF(1), TNFRSF1A(1), TNFSF8(1)	5773994	10	10	10	4	3	3	3	1	0	0	0.61	0.98
381	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	93	CD80(1), CD86(2), CHUK(1), CXCL9(1), FADD(1), FOS(1), IFNA1(2), IFNA13(2), IFNA5(1), IFNA8(1), IFNAR2(1), IFNB1(1), IKBKB(1), IKBKE(1), IL8(1), IRAK1(2), IRAK4(1), IRF3(2), LBP(2), MAP2K3(1), MAP2K4(1), MAP2K6(1), MAP3K7(3), MAPK14(1), MAPK8(1), MAPK9(1), NFKB1(1), PIK3CA(2), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R5(1), RELA(1), SPP1(1), STAT1(2), TBK1(1), TIRAP(1), TLR1(1), TLR3(2), TLR4(4), TLR5(1), TLR6(2), TLR7(1), TLR8(2), TNF(1), TRAF6(2)	37185452	67	58	67	17	5	14	16	27	5	0	0.61	0.99
382	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(1), GAD1(1), GAD2(1)	2461360	4	4	4	0	1	0	1	1	1	0	0.61	0.99
383	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	ABP1(2), AGXT(1), AGXT2(2), ALAS1(1), AOC2(4), AOC3(1), BHMT(1), CHDH(1), CHKA(1), CHKB(1), DMGDH(2), GARS(1), GLDC(2), MAOA(2), MAOB(1), PSAT1(1), PSPH(1), RDH12(1), RDH13(1), SARS2(1), SHMT1(1), SHMT2(1), TARS(2), TARS2(2)	18279579	34	31	34	12	4	3	10	7	10	0	0.62	0.99
384	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CARS(3), LDHB(1), LDHC(1)	2970053	5	5	5	1	0	0	3	2	0	0	0.62	0.99
385	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	8	GPI(2), HK1(1), PGK1(2), PKLR(1)	3307936	6	6	6	2	0	0	4	1	1	0	0.62	0.99
386	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(1), ACAD9(2), ADH1B(1), ADH1C(1), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), AKR1C4(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), BAAT(1), CYP27A1(1), CYP7A1(1), RDH12(1), RDH13(1), SOAT2(2), SRD5A2(1)	13798749	24	22	24	8	1	4	6	7	6	0	0.62	0.99
387	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMK4(3)	4889723	8	8	8	4	1	1	3	2	1	0	0.62	0.99
388	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(1), SHMT1(1), SHMT2(1)	2265880	4	4	4	1	1	0	1	1	1	0	0.62	0.99
389	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(1), ELK1(2), FOS(1), GRB2(2), MAP2K4(1), MAP3K1(1), MAPK8(1), PDGFRA(3), PIK3CA(2), PIK3R1(1), PRKCA(1), RASA1(1), SHC1(1), SOS1(3), SRF(1), STAT1(2), STAT3(1), STAT5A(2)	15043225	27	24	27	8	3	4	13	5	2	0	0.62	0.99
390	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	GRB2(2), IGF1R(1), IRS1(6), PIK3CA(2), PIK3R1(1), SHC1(1), SOS1(3)	7909616	16	13	16	6	0	4	8	2	2	0	0.63	0.99
391	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMK4(3), HDAC5(1), MEF2A(1), MEF2C(1), MEF2D(1), PPARA(1), PPP3CC(1), SLC2A4(1)	8556433	15	15	15	6	1	2	8	3	1	0	0.63	0.99
392	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AP2A1(2), BTK(1), EEA1(1), GSK3A(2), GSK3B(1), LYN(1), PDPK1(1), PFKP(2), PRKCE(1), PRKCZ(2), VAV2(4)	9792746	18	17	18	4	3	2	9	4	0	0	0.63	0.99
393	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	CALM3(1), EGFR(7), ELK1(2), GRB2(2), MAP2K4(1), MAP3K1(1), MAPK8(1), MEF2A(1), MEF2C(1), MEF2D(1), PRKCA(1), PTK2(1), PTK2B(1), SHC1(1), SOS1(3), SRC(4)	14773517	29	26	27	12	2	3	17	4	3	0	0.63	0.99
394	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	GRB2(2), MEF2A(1), MEF2C(1), MEF2D(1), NTRK1(4), PIK3CA(2), PIK3R1(1), RPS6KA1(1), SHC1(1)	8071503	14	13	14	10	2	2	6	3	1	0	0.63	0.99
395	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(2), ARHGAP5(2), CASP1(2), CASP9(1), PRF1(2)	5756868	9	9	9	3	1	2	1	4	1	0	0.64	1.00
396	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	82	CD44(1), CD47(1), CHAD(1), COL11A1(5), COL11A2(4), COL1A1(1), COL1A2(2), COL2A1(1), COL3A1(4), COL4A1(3), COL4A2(1), COL4A4(3), COL4A6(5), COL5A1(1), COL5A2(2), COL5A3(7), COL6A3(11), COL6A6(6), DAG1(3), FN1(1), FNDC1(2), FNDC4(1), FNDC5(1), GP5(1), HSPG2(7), ITGA1(1), ITGA10(2), ITGA2B(4), ITGA3(2), ITGA4(3), ITGA5(1), ITGA6(1), ITGA8(3), ITGAV(2), ITGB6(1), ITGB7(4), LAMA1(6), LAMA2(8), LAMA3(7), LAMA4(2), LAMB1(5), LAMB2(3), LAMB3(1), LAMB4(4), LAMC1(3), LAMC2(1), LAMC3(4), RELN(8), SDC1(4), SDC2(2), SPP1(1), SV2A(3), SV2B(2), THBS1(2), THBS2(4), THBS3(3), THBS4(1), TNC(1), TNN(4), TNR(3), TNXB(4), VWF(4)	92544547	189	127	188	56	23	33	77	35	21	0	0.64	1.00
397	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(1), AGTR2(2), EDNRA(1), EGFR(7), FOS(1), NFKB1(1), PRKCA(1), RELA(1)	9209570	15	15	15	8	4	2	4	4	1	0	0.64	1.00
398	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOC(1)	1690173	2	2	2	0	2	0	0	0	0	0	0.65	1.00
399	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	FOS(1), GRB2(2), IL2RA(2), IL2RB(1), IRS1(6), JAK3(3), PIK3CA(2), PIK3R1(1), SHC1(1), SOS1(3), STAT5A(2), STAT5B(3)	14800824	27	24	27	9	2	6	13	3	3	0	0.65	1.00
400	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(2), GNAS(3), LIMK1(1), MYL2(1), NOX1(1), PLCB1(4), PPP1R12B(4), PRKCA(1), PTK2(1)	11018345	18	18	17	8	1	1	10	3	3	0	0.65	1.00
401	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(2), ACAT2(1), ACOT11(1), DHRS2(1), DHRS7(1), ECHS1(1), EHHADH(2), HADHA(1), MYST3(3), MYST4(5), YOD1(3)	11241811	21	18	21	5	0	3	7	5	6	0	0.65	1.00
402	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM3(1), DLG4(2), GRIN2A(3), GRIN2B(3), GRIN2C(1), GRIN2D(3), NOS1(2), PPP3CC(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(1)	10597436	20	18	19	10	7	4	4	3	2	0	0.65	1.00
403	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(1), ALOX5(1), CYP1A2(1), CYP2C18(2), CYP2C19(4), CYP2C9(1), CYP2E1(1), CYP2J2(1), CYP3A43(1), PLA2G12A(1), PLA2G12B(1), PLA2G2F(1), PLA2G4A(1), PLA2G6(1), RDH12(1), RDH13(1)	10582968	20	19	20	6	2	2	10	4	2	0	0.66	1.00
404	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(2), CD5(1), IFNA1(2), IFNB1(1), IL13(2), ITGAX(1), TLR4(4), TLR7(1)	8216955	14	13	14	4	0	4	3	7	0	0	0.66	1.00
405	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	PAH(3), TAT(2)	3858279	5	5	5	6	0	1	0	2	2	0	0.67	1.00
406	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1)	927961	1	1	1	1	0	0	0	1	0	0	0.67	1.00
407	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	66	ACACB(4), ACSL1(2), ACSL3(2), ACSL4(1), ACSL6(1), ADIPOQ(1), CHUK(1), CPT1A(2), CPT1B(2), CPT1C(1), CPT2(1), G6PC(1), IKBKB(1), IRS1(6), IRS4(5), JAK2(2), JAK3(3), LEPR(1), MAPK8(1), MAPK9(1), NFKB1(1), POMC(1), PPARA(1), PPARGC1A(2), PRKAA2(2), PRKAG3(1), PRKCQ(3), RELA(1), RXRA(2), RXRB(2), SLC2A1(1), SLC2A4(1), STAT3(1), TNF(1), TNFRSF1A(1), TRAF2(1), TYK2(2)	34612403	63	54	63	12	8	14	17	13	11	0	0.67	1.00
408	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	60	AGPAT3(1), AGPAT4(2), AGPAT6(1), CDS1(1), CHKA(1), CHKB(1), CRLS1(1), DGKA(3), DGKB(3), DGKD(2), DGKE(1), DGKH(3), DGKI(1), ETNK2(2), GNPAT(4), GPAM(1), GPD2(1), LCAT(2), LYPLA2(1), MYST3(3), MYST4(5), PLA2G12A(1), PLA2G12B(1), PLA2G2F(1), PLA2G4A(1), PLA2G6(1), PLD1(1), PLD2(1), PPAP2A(1), PTDSS1(1)	27356663	49	44	49	15	4	6	17	16	6	0	0.67	1.00
409	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(1), RDH12(1), RDH13(1)	2076871	3	3	3	0	1	0	1	0	1	0	0.67	1.00
410	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(1), DNMT1(2), DNMT3A(3), DNMT3B(2), MARS(2), MARS2(3)	7584595	13	13	13	3	1	3	5	4	0	0	0.67	1.00
411	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(3), BRAF(2), DUSP9(2), EEF2K(2), GRB2(2), MKNK1(1), MOS(1), NFKB1(1), RPS6KA1(1), RPS6KA2(1), SHC1(1), SOS1(3), SOS2(1)	12735845	21	21	21	9	1	2	9	5	4	0	0.68	1.00
412	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(1), CARS(3), DARS(1), DARS2(1), FARSA(4), FARSB(1), GARS(1), IARS(1), IARS2(2), KARS(1), MARS(2), MARS2(3), MTFMT(3), NARS2(2), PARS2(1), QARS(1), RARS(1), RARS2(2), SARS2(1), TARS(2), TARS2(2), VARS(1), VARS2(3), WARS(1)	24300098	42	38	42	12	6	7	19	8	2	0	0.68	1.00
413	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GNPDA2(1), HEXA(2), HEXB(1), HK1(1), HK2(1), HK3(3), RENBP(2), UAP1(2)	7342680	14	12	14	1	1	2	5	4	2	0	0.68	1.00
414	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	5	DBH(2), GAD1(1)	2260812	3	3	3	3	1	0	0	2	0	0	0.68	1.00
415	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	11	DNMT1(2), MTNR1A(1), PTGDR(1), PTGFR(3)	4318168	7	7	7	1	2	0	3	1	1	0	0.68	1.00
416	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(4), ATP6V0D1(1), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), SHMT1(1)	6853412	11	11	10	2	3	0	2	5	1	0	0.68	1.00
417	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(4), ATP6V0D1(1), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), SHMT1(1)	6853412	11	11	10	2	3	0	2	5	1	0	0.68	1.00
418	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(4), ATP6V0D1(1), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), SHMT1(1)	6853412	11	11	10	2	3	0	2	5	1	0	0.68	1.00
419	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	HSD17B2(1), HSD17B4(1), HSD3B1(2), HSD3B2(1)	3617463	5	5	5	2	0	1	2	2	0	0	0.68	1.00
420	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ACAT1(2), ACAT2(1), ALDH1A1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ECHS1(1), EHHADH(2), GAD1(1), GAD2(1), HADHA(1), L2HGDH(2), OXCT1(2)	11460534	20	18	20	8	0	4	8	6	2	0	0.68	1.00
421	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	28	CMAS(1), CYB5R1(1), GFPT2(1), GNPDA2(1), HEXA(2), HEXB(1), HK1(1), HK2(1), HK3(3), MTMR1(2), MTMR6(2), NANS(1), RENBP(2), UAP1(2)	12323838	21	19	21	5	4	3	5	5	4	0	0.69	1.00
422	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(2), ALDH1A1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), AOC2(4), AOC3(1), DDC(1), HAL(1), HNMT(1), MAOA(2), MAOB(1)	10873040	18	18	18	8	1	2	4	6	5	0	0.69	1.00
423	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(1), ELK1(2), FOS(1), GRB2(2), IL6R(1), JAK2(2), JAK3(3), SHC1(1), SOS1(3), SRF(1), STAT3(1)	10230094	18	16	18	7	2	2	9	3	2	0	0.69	1.00
424	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(1), CPOX(1), HMBS(1), PPOX(2)	3484115	5	5	4	3	1	2	1	0	1	0	0.69	1.00
425	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	8	GREB1(4), MTA3(2)	3640059	6	6	6	2	1	0	4	1	0	0	0.69	1.00
426	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CXCR3(2), EGFR(7), ITGA1(1), MYL2(1), MYLK(6), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTK2(1), PXN(5), TLN1(1)	14438758	27	24	27	11	5	2	9	8	3	0	0.70	1.00
427	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	CASP9(1), CHUK(1), ELK1(2), NFKB1(1), PIK3CA(2), PIK3R1(1), RALGDS(1), RELA(1), RHOA(2)	7852662	12	12	12	5	1	2	4	3	2	0	0.70	1.00
428	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), RDH5(1)	1778074	2	2	2	2	0	2	0	0	0	0	0.70	1.00
429	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(2), BAK1(1), BID(1), BIRC3(2), CASP6(1), CASP7(1), CASP9(1), DIABLO(1)	5944434	10	10	10	6	0	1	6	3	0	0	0.70	1.00
430	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	DHRS2(1), DHRS7(1), METTL6(1), PRMT5(2), PRMT8(3), WBSCR22(1)	5959227	9	9	9	2	1	1	3	3	1	0	0.71	1.00
431	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2)	3501749	5	5	5	3	0	2	0	2	1	0	0.71	1.00
432	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2)	3501749	5	5	5	3	0	2	0	2	1	0	0.71	1.00
433	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOC(1), G6PD(4), GPI(2), H6PD(1), PFKP(2), PGD(1), PGLS(1), PRPS1L1(2), RPIA(1), TKT(2)	8736340	17	15	17	2	3	4	7	2	1	0	0.71	1.00
434	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	31	GTF2B(1), GTF2E1(1), GTF2H4(1), GTF2IRD1(3), TAF1(5), TAF12(1), TAF2(2), TAF4(3), TAF5(1), TAF5L(1), TAF6(2), TAF6L(3), TAF9(1)	15721611	25	24	25	8	4	6	8	6	1	0	0.71	1.00
435	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN2(3), ACTN3(2), ITGA1(1), PTK2(1), PXN(5), SPTAN1(5), SRC(4), TLN1(1)	12446062	22	22	20	7	4	1	12	2	3	0	0.71	1.00
436	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	BCR(1), BTK(1), CD19(2), CD22(3), CR2(1), CSK(1), DAG1(3), GRB2(2), GSK3A(2), GSK3B(1), INPP5D(4), ITPR1(3), ITPR2(5), ITPR3(3), LYN(1), MAP4K1(1), NFATC1(1), NFATC2(1), PDK1(1), PIK3CA(2), PIK3R1(1), PLCG2(1), PPP3CC(1), PTPRC(3), SHC1(1), SOS1(3), SOS2(1), VAV1(2)	30882356	52	48	52	20	4	7	21	13	7	0	0.72	1.00
437	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(2), C5(1), C6(2), C7(3), C8A(1)	5623387	9	8	9	3	1	1	2	3	2	0	0.72	1.00
438	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS2(1), SULT1E1(1), SULT2A1(1)	2774113	4	4	4	0	0	0	1	2	1	0	0.73	1.00
439	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(1), ATP6AP1(4), ATP6V0D1(1), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), SHMT1(1)	7100054	11	11	10	2	3	0	2	5	1	0	0.73	1.00
440	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ABP1(2), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), AMDHD1(1), AOC2(4), AOC3(1), DDC(1), HAL(1), HNMT(1), MAOA(2), MAOB(1), METTL6(1), PRMT5(2), PRMT8(3), UROC1(2), WBSCR22(1)	16708635	28	27	28	9	3	1	8	11	5	0	0.73	1.00
441	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SEC61A2(1), SRP68(2), SRPR(1)	3412338	4	4	4	2	0	1	2	0	1	0	0.73	1.00
442	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX12(1), ALOX15(1), ALOX5(1), CYP4F2(1), EPX(2), LPO(1), PLA2G4A(1), PLA2G6(1), PTGDS(1), PTGIS(3), PTGS1(1), PTGS2(1), TBXAS1(2), TPO(4)	11764879	21	20	21	5	3	3	9	2	4	0	0.73	1.00
443	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1A(1), ARPC3(1), PDGFRA(3), PIK3CA(2), PIK3R1(1)	6019778	8	8	8	4	0	3	1	3	1	0	0.74	1.00
444	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	APC(8), DAG1(3), DLG4(2), EPHB2(1), ITPR1(3), ITPR2(5), ITPR3(3), KCNJ9(1), PITX2(1), RYR1(11)	20009396	38	32	38	11	5	3	11	16	3	0	0.74	1.00
445	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(2), BAK1(1), BID(1), CASP8AP2(1), CASP9(1), CES1(1)	4612714	7	7	7	3	0	1	4	2	0	0	0.74	1.00
446	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	108	ATP12A(2), ATP4A(1), ATP5B(2), ATP5G2(1), ATP5J2(1), ATP5O(1), ATP6AP1(4), ATP6V0A2(1), ATP6V0D1(1), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(1), ATP6V1F(1), COX10(1), COX15(1), COX6B1(1), CYC1(1), NDUFA7(1), NDUFA9(1), NDUFB11(1), NDUFB2(1), NDUFB9(1), NDUFS1(1), NDUFS4(1), NDUFV3(2), PPA2(1), SDHA(1), TCIRG1(3), UQCRB(1), UQCRC1(1)	24165707	39	39	37	11	5	4	13	11	6	0	0.74	1.00
447	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	GGPS1(1), IDI2(1)	1913062	2	2	2	1	0	0	1	1	0	0	0.74	1.00
448	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ANGPTL2(1), DAG1(3), DGKA(3), GCA(1), ITPKB(4), ITPR1(3), ITPR2(5), ITPR3(3), NR1I3(1), PDE3A(4), PIK3CA(2), PIK3R1(1), PSME1(2), RIPK3(2)	20841276	35	32	35	13	2	4	13	9	7	0	0.75	1.00
449	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F2(3), F5(3), F7(1), F8(4), F9(1), FGA(3), FGB(2), LPA(2), PLAU(2), SERPINE1(1), VWF(4)	15347354	26	24	26	10	4	3	10	6	3	0	0.75	1.00
450	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(2), HLA-A(1), KLRC2(2), KLRC3(1), PIK3CA(2), PIK3R1(1), PTK2B(1), VAV1(2)	8176796	12	11	11	7	0	1	1	7	3	0	0.75	1.00
451	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PRKCA(1), PTK2B(1)	3038990	4	4	4	1	2	0	1	1	0	0	0.75	1.00
452	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACTG1(2), ACTN2(3), ACTN3(2), ACVR1B(1), ACVR1C(2), CDH1(2), CREBBP(7), CSNK2A1(1), CSNK2B(1), CTNNA1(2), CTNNA3(1), CTNNB1(2), EGFR(7), EP300(1), ERBB2(4), FARP2(1), IGF1R(1), INSR(6), IQGAP1(2), MAP3K7(3), MET(4), MLLT4(2), NLK(1), PARD3(2), PTPRB(1), PTPRF(4), PTPRJ(1), PTPRM(1), PVRL1(1), PVRL4(2), RHOA(2), SNAI1(2), SNAI2(1), SORBS1(2), SRC(4), SSX2IP(1), TCF7L2(2), TGFBR2(3), TJP1(3), VCL(2), WAS(1), WASF2(1), YES1(1)	52612883	95	75	92	21	8	15	33	25	14	0	0.75	1.00
453	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	32	AARS(1), AARS2(1), ADSL(1), ADSSL1(3), AGXT(1), AGXT2(2), ASNS(2), ASRGL1(1), ASS1(1), CAD(5), DARS(1), DARS2(1), DDO(3), DLAT(1), GAD1(1), GAD2(1), NARS2(2)	16012567	28	27	28	13	4	2	11	9	2	0	0.76	1.00
454	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	78	ACVR1(2), ACVR1B(1), BMPR1A(1), BMPR2(3), BUB1(1), CDS1(1), CLK1(1), CLK4(1), CSNK2A1(1), CSNK2B(1), DGKA(3), DGKB(3), DGKD(2), DGKE(1), DGKH(3), INPP1(1), INPP4A(1), INPP4B(1), INPPL1(1), ITPKB(4), MAP3K10(2), MOS(1), NEK1(2), NEK3(1), OCRL(1), PIK3C2A(3), PIK3C2B(3), PIK3CA(2), PIK3CB(1), PIK3CG(3), PLCB1(4), PLCB2(4), PLCB3(2), PLCB4(1), PLCG2(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCQ(3), PRKCZ(2), PRKD1(2), PRKG1(1), RPS6KA1(1), RPS6KA2(1), RPS6KA4(1)	47601602	82	66	82	24	13	13	26	23	7	0	0.76	1.00
455	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(2), GSN(1), ITGA1(1), MYL2(1), MYLK(6), PIK3CA(2), PIK3R1(1), PTK2(1), PXN(5), SHC1(1), SRC(4), TLN1(1)	16666791	26	26	24	10	3	3	12	5	3	0	0.76	1.00
456	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS2(1), DHRS7(1), PON3(1), RDH12(1), RDH13(1)	3699232	5	5	5	0	1	1	1	0	2	0	0.77	1.00
457	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(5), CDC25B(2), MYT1(2)	6178089	9	8	9	2	0	1	4	3	1	0	0.77	1.00
458	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(2), ANGPTL2(1), FLNA(1), FLNC(3), FSCN3(1), LIMK1(1), MYH2(5), MYLK(6), MYLK2(1), PAK2(1), PAK3(5), PAK6(2), PAK7(1), PFN2(1)	18413045	31	31	31	7	4	1	14	10	2	0	0.77	1.00
459	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	53	AK3(2), CAD(5), CDA(1), CTPS2(1), DCK(1), DCTD(1), DHODH(1), DPYD(3), DPYS(1), ENTPD1(2), ITPA(1), NT5E(2), POLB(1), POLD1(1), POLD2(2), POLE(2), POLG(1), POLQ(3), POLR2B(2), POLR2C(1), POLR2I(1), UCK2(1), UMPS(1), UNG(1), UPB1(1), UPP1(1)	24226493	40	37	40	10	7	4	15	8	6	0	0.77	1.00
460	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(1), ETS1(1), ETS2(1), FOS(1), HDAC5(1), NCOR2(1), RBL1(1), RBL2(3), SIN3A(2), SIN3B(2)	10077364	15	15	15	3	3	1	8	2	1	0	0.78	1.00
461	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), CS(1), ME1(2)	3867016	6	6	6	3	0	0	4	2	0	0	0.79	1.00
462	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR3(2), CD4(1), CXCR3(2), IL12RB2(3), IL18R1(2), IL4R(2)	8730677	12	12	12	0	1	5	4	2	0	0	0.79	1.00
463	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	MARS(2), MARS2(3), PAPSS2(1), SCLY(2), SEPHS1(1)	5233572	9	8	9	0	0	1	3	4	1	0	0.79	1.00
464	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS(3), LDHAL6B(1), LDHB(1), LDHC(1), SULT1C2(1), SULT4A1(1)	5498530	8	8	8	2	0	0	5	3	0	0	0.80	1.00
465	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ5(1), NDUFB11(1)	1814673	2	2	2	2	0	0	1	0	1	0	0.80	1.00
466	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(3), ASH2L(1), CTCFL(2), EHMT2(1), EZH1(4), HCFC1(3), JMJD6(2), KDM6A(2), MEN1(1), MLL(5), MLL2(1), MLL3(7), MLL4(4), MLL5(3), NSD1(2), OGT(2), PAXIP1(1), PRDM2(1), PRDM7(2), PRDM9(5), PRMT1(1), PRMT5(2), PRMT8(3), SETD2(6), SETD7(1), SETDB1(3), SETDB2(1), SETMAR(1), STK38(3), SUV39H2(1), SUV420H1(2), WHSC1(2), WHSC1L1(1)	49388924	79	69	78	20	4	5	34	25	11	0	0.80	1.00
467	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(3), MBTPS1(1), MBTPS2(1), SCAP(1)	4475758	6	6	6	2	1	1	2	2	0	0	0.80	1.00
468	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(3), ACO1(2), ACO2(1), ACSS1(1), FH(1), MDH2(1)	6045006	9	9	9	0	0	1	4	3	1	0	0.80	1.00
469	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	134	ADCY1(4), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY9(5), ATF1(3), ATP2A2(1), ATP2A3(1), CALM3(1), CAMK2B(2), CAMK2D(1), CAMK2G(1), CORIN(1), ETS2(1), FOS(1), GABPA(2), GBA2(2), GJA1(2), GNB2(2), GNG13(1), GRK5(1), GRK6(1), GUCY1A3(1), IGFBP6(1), ITPR1(3), ITPR2(5), ITPR3(3), MIB1(5), MYL2(1), MYL4(3), MYLK2(1), NFKB1(1), NOS1(2), NOS3(2), PLCB3(2), PLCG2(1), PRKAR2A(1), PRKAR2B(1), PRKCA(1), PRKCE(1), PRKCH(1), PRKCQ(3), PRKCZ(2), PRKD1(2), RGS18(2), RGS4(2), RGS7(4), RGS9(2), RYR1(11), RYR2(15), RYR3(4), SLC8A1(2), TNXB(4), USP5(1), YWHAB(1)	72563205	137	104	136	40	30	8	48	39	12	0	0.80	1.00
470	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), CS(1), FH(1), OGDH(2), SDHA(1)	4203499	6	6	6	1	0	2	2	1	1	0	0.80	1.00
471	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	SHMT1(1), SHMT2(1)	1661782	2	2	2	0	1	0	0	1	0	0	0.80	1.00
472	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	FOS(1), MAPK14(1), THBS1(2)	3212759	4	4	4	3	0	0	2	2	0	0	0.80	1.00
473	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(2), ACO2(1), FH(1), MDH2(1)	4059691	5	5	5	0	0	1	2	1	1	0	0.81	1.00
474	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	45	APAF1(2), CASP1(2), CASP2(1), CASP4(1), CASP6(1), CASP7(1), CASP9(1), DAXX(1), FADD(1), IKBKE(1), NFKB1(1), NGFR(1), NR3C1(2), NTRK1(4), PTPN13(4), TNF(1), TNFRSF1A(1), TRAF1(4), TRAF2(1), TRAF6(2)	19093637	33	28	33	11	6	7	10	8	2	0	0.81	1.00
475	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	38	AKR1B1(3), ALDOC(1), FUK(1), HK1(1), HK2(1), HK3(3), KHK(1), MPI(1), MTMR1(2), MTMR6(2), PFKFB2(1), PFKFB3(2), PFKFB4(1), PFKP(2), RDH12(1), RDH13(1)	15159044	24	24	24	7	6	5	8	2	3	0	0.81	1.00
476	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	CAT(1), GHR(1), IGF1R(1), PIK3CA(2), PIK3R1(1), SHC1(1)	5609153	7	7	7	4	1	2	2	1	1	0	0.81	1.00
477	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	20	AARS(1), ADSL(1), AGXT(1), AGXT2(2), ASNS(2), CAD(5), DARS(1), DDO(3), GAD1(1), GAD2(1)	10988586	18	17	18	10	3	2	6	5	2	0	0.81	1.00
478	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS2(1), DHRS7(1), MYST3(3), MYST4(5)	7137865	10	10	10	3	0	2	1	4	3	0	0.82	1.00
479	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA4(1), PSMB1(1), PSMB4(1), PSMB5(1), PSMB6(1)	3939621	5	5	5	3	0	0	2	3	0	0	0.82	1.00
480	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	17	CHUK(1), IKBKB(1), MAP3K1(1), MAP3K5(2), MAPK14(1), MAPK8(1), NFKB1(1), RELA(1), TNFRSF9(1), TRAF2(1)	8515347	11	11	11	3	2	4	1	3	1	0	0.82	1.00
481	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	39	ALPL(2), ALPP(2), ASCC3(5), ATP13A2(3), DDX18(1), DDX23(1), DDX4(1), DDX41(1), DDX47(1), DDX52(2), DDX54(2), DDX55(1), ENTPD7(1), EP400(2), ERCC2(1), FPGS(1), IFIH1(1), MOV10L1(2), NUDT5(1), QDPR(1), RAD54L(2), SETX(2), SKIV2L2(1), SMARCA2(2), SPR(2)	26095152	41	38	41	6	6	6	17	9	3	0	0.82	1.00
482	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	36	BCR(1), BTK(1), CD19(2), CSK(1), DAG1(3), EPHB2(1), GRB2(2), ITPKB(4), LYN(1), NFAT5(1), NFKB1(1), PIK3CA(2), PIK3R1(1), PLCG2(1), SERPINA4(2), SHC1(1), SOS1(3), SOS2(1), VAV1(2)	20708368	31	29	31	15	3	5	14	6	3	0	0.82	1.00
483	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(1), POLD2(2), POLE(2), POLG(1), POLQ(3)	7158005	10	10	10	4	0	3	6	1	0	0	0.82	1.00
484	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(1)	1486039	1	1	1	3	0	0	0	0	1	0	0.82	1.00
485	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	33	ACTN2(3), ACTN3(2), BCR(1), CSK(1), GRB2(2), ITGA1(1), MAPK8(1), PPP1R12B(4), PTK2(1), PXN(5), SHC1(1), SOS1(3), SRC(4), TLN1(1), VCL(2)	19281295	32	31	30	9	3	3	19	4	3	0	0.82	1.00
486	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	106	ADA(1), ADCY1(4), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADK(1), ADSL(1), AK2(1), ALLC(2), AMPD1(2), AMPD2(2), AMPD3(1), ATIC(2), ATP1B1(1), ATP5B(2), ATP5G2(1), ATP5J2(1), DCK(1), ENPP1(2), ENPP3(2), ENTPD1(2), GART(3), GDA(1), GMPS(2), GUCY1A3(1), GUCY2C(3), IMPDH1(1), ITPA(1), NPR1(1), NPR2(2), NT5E(2), PAPSS2(1), PDE1A(1), PDE4A(2), PDE4C(1), PDE6B(2), PDE6C(2), PDE7B(1), PDE8A(1), PFAS(2), PKLR(1), POLB(1), POLD1(1), POLD2(2), POLE(2), POLG(1), POLQ(3), POLR2B(2), POLR2C(1), POLR2I(1), PRPS1L1(2), PRUNE(1)	54841511	90	78	87	30	16	14	26	18	16	0	0.83	1.00
487	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	EGR1(2), KLK2(1), NGFR(1)	3101211	4	4	4	2	1	1	1	1	0	0	0.83	1.00
488	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	25	BIRC3(2), FADD(1), MAP2K4(1), MAP3K3(1), MAP3K7(3), NFKB1(1), TNF(1), TNFAIP3(4), TNFRSF1A(1), TRAF2(1)	10644511	16	16	16	5	1	3	7	4	1	0	0.83	1.00
489	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	FURIN(2)	1995317	2	2	2	2	0	1	0	0	1	0	0.83	1.00
490	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	20	ALDOC(1), MDH2(1), ME1(2), ME3(1), PGK1(2), PKLR(1), RPIA(1), TKT(2)	7516569	11	11	11	2	2	1	4	3	1	0	0.83	1.00
491	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLS2(1)	1841117	2	2	2	1	0	0	2	0	0	0	0.83	1.00
492	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	GOSR1(1), STX11(1), STX16(1), STX3(2), STX5(2), STX6(1), VTI1A(1)	7044921	9	9	9	3	1	1	2	2	3	0	0.83	1.00
493	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	FMOD(1)	1623106	1	1	1	1	0	0	0	1	0	0	0.84	1.00
494	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA4(1), PSMB1(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC3(4), PSMD1(1), PSMD13(1)	7352160	11	10	11	4	0	0	5	4	2	0	0.84	1.00
495	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(3), ALDOC(1), HK1(1), HK2(1), HK3(3), KHK(1), MPI(1), PFKFB3(2), PFKFB4(1), PFKP(2)	10315150	16	16	16	6	3	4	6	1	2	0	0.84	1.00
496	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADM(1), ACADSB(2), ACAT1(2), ACAT2(1), ALDH1A1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), AOX1(4), ECHS1(1), EHHADH(2), HADHA(1), IVD(2), MCCC2(1), OXCT1(2), PCCB(1)	16142208	27	23	27	12	2	5	8	8	4	0	0.84	1.00
497	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(1), CRY1(2), CSNK1E(1), NPAS2(2), PER1(2), PER2(1), PER3(1)	7064708	10	10	9	4	0	2	2	5	1	0	0.84	1.00
498	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(1), NFKB1(1), PLCB1(4), PRKCA(1), RELA(1), TNF(1)	6794913	9	9	9	4	2	2	3	2	0	0	0.85	1.00
499	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	CSF3(1), FLT3(2), KITLG(1)	3684735	4	4	4	2	0	1	1	1	1	0	0.85	1.00
500	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	JAK2(2), STAT1(2)	3690289	4	4	4	1	0	0	2	1	1	0	0.85	1.00
501	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PRKCA(1), TGM2(1)	2217781	2	2	2	2	1	0	0	1	0	0	0.85	1.00
502	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), SNCAIP(1)	2814528	3	3	3	3	0	1	2	0	0	0	0.85	1.00
503	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	BPNT1(1), PAPSS2(1), SULT1A1(1), SULT1E1(1), SULT2A1(1)	3903402	5	5	5	0	0	0	1	3	1	0	0.86	1.00
504	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	CDKN1A(1), EPOR(1), JAK2(2), NFKB1(1), RELA(1)	5226260	6	6	6	1	2	1	1	1	1	0	0.86	1.00
505	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	26	CALM3(1), GRB2(2), MAP2K3(1), MAP2K4(1), MAP3K1(1), MAPK14(1), MAPK8(1), PRKCA(1), PTK2B(1), SHC1(1), SOS1(3), SRC(4)	11719968	18	17	16	6	3	2	11	1	1	0	0.86	1.00
506	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	64	A2M(1), BDKRB1(4), BDKRB2(3), C2(1), C3(2), C4BPA(1), C4BPB(1), C5(1), C5AR1(2), C6(2), C7(3), C8A(1), C8B(1), CD55(1), CPB2(1), CR1(2), CR2(1), F13A1(2), F2(3), F2R(2), F5(3), F7(1), F8(4), F9(1), FGA(3), FGB(2), KLKB1(2), KNG1(1), MASP1(1), MASP2(2), PLAU(2), PLAUR(1), PROC(1), PROS1(1), SERPINA5(2), SERPINC1(1), SERPINE1(1), VWF(4)	39995553	68	57	68	20	11	10	22	18	7	0	0.86	1.00
507	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ARPC1A(1), ARPC3(1), NCKAP1(2), NTRK1(4), PIR(1), WASF2(1)	6897790	10	9	10	3	2	1	5	2	0	0	0.86	1.00
508	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	17	ACY1(1), ARG1(1), CPS1(4), ODC1(1), OTC(1), SMS(1)	6908209	9	9	9	6	0	1	3	3	2	0	0.86	1.00
509	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(1), EIF4EBP1(1), NR4A3(1), WDR1(2)	4663387	5	5	5	0	1	0	2	2	0	0	0.86	1.00
510	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25B(2), MNAT1(1)	3901939	4	4	4	3	0	0	4	0	0	0	0.86	1.00
511	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	18	EXT1(1), EXTL1(1), EXTL3(2), GLCE(1), HS3ST3A1(1), HS3ST5(1), HS6ST3(1), NDST1(1), NDST2(2)	8843013	11	11	11	6	2	3	3	2	1	0	0.87	1.00
512	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ANGPTL2(1), ARHGAP1(1), ARHGEF11(2), BTK(1), INPPL1(1), ITPR1(3), ITPR2(5), ITPR3(3), LIMK1(1), MYLK(6), MYLK2(1), PAK2(1), PAK3(5), PAK6(2), PAK7(1), PDK1(1), PIK3CA(2), PIK3CG(3), PIK3R1(1), PITX2(1), PTEN(2), SAG(1)	29722180	45	44	45	14	2	5	17	15	6	0	0.87	1.00
513	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT2(2), IARS(1), IARS2(2), ILVBL(1), VARS(1), VARS2(3)	8187423	10	10	10	5	3	0	4	2	1	0	0.88	1.00
514	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	64	CASP9(1), KDR(1), KRAS(2), MAPK14(1), MAPKAPK3(1), NFAT5(1), NFATC1(1), NFATC2(1), NFATC4(1), NOS3(2), NRAS(2), PIK3CA(2), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R5(1), PLA2G12A(1), PLA2G12B(1), PLA2G2F(1), PLA2G4A(1), PLA2G6(1), PLCG2(1), PPP3CC(1), PRKCA(1), PRKCG(1), PTGS2(1), PTK2(1), PXN(5), SPHK1(1), SRC(4), VEGFA(1)	28313187	46	41	42	18	4	10	16	13	3	0	0.88	1.00
515	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	METTL6(1), PRMT5(2), PRMT8(3), WBSCR22(1)	5887718	7	7	7	3	1	0	3	3	0	0	0.88	1.00
516	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	GPD2(1), SDHA(1), UQCRC1(1)	2901740	3	3	3	3	0	1	1	0	1	0	0.88	1.00
517	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C2(1), C3(2), C5(1), C6(2), C7(3), C8A(1), MASP1(1), MASP2(2)	9566411	13	12	13	7	2	1	3	4	3	0	0.88	1.00
518	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	68	CALM3(1), CDS1(1), DGKA(3), DGKB(3), DGKD(2), DGKE(1), DGKH(3), DGKI(1), INPP1(1), INPP4A(1), INPP4B(1), INPP5D(4), INPPL1(1), ITPK1(1), ITPKB(4), ITPR1(3), ITPR2(5), ITPR3(3), OCRL(1), PI4KA(1), PI4KB(2), PIK3C2A(3), PIK3C2B(3), PIK3CA(2), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R5(1), PIP4K2A(1), PIP4K2B(1), PIP5K1A(1), PIP5K1C(1), PLCB1(4), PLCB2(4), PLCB3(2), PLCB4(1), PLCD4(2), PLCE1(1), PLCG2(1), PLCZ1(1), PRKCA(1), PRKCG(1), PTEN(2), SYNJ1(2)	51645361	85	71	85	24	7	16	28	25	9	0	0.89	1.00
519	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(1), PTPRU(1), STAT1(2), STAT2(1), TYK2(2)	5388667	7	7	7	2	0	0	3	4	0	0	0.89	1.00
520	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), GPR161(1), GPR34(1), GPR45(1), GPR75(1)	4413282	5	5	5	1	1	0	4	0	0	0	0.89	1.00
521	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	46	AASDHPPT(1), AASS(2), ACAT1(2), ACAT2(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), DLST(1), ECHS1(1), EHHADH(2), EHMT2(1), HADHA(1), HSD17B4(1), NSD1(2), OGDH(2), PLOD1(1), PLOD2(1), PLOD3(3), RDH12(1), RDH13(1), SETD7(1), SETDB1(3), SHMT1(1), SHMT2(1), SPCS1(1), SPCS3(2), SUV39H2(1), TMLHE(1)	24204325	40	35	40	11	5	4	13	14	4	0	0.89	1.00
522	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	79	BRAF(2), CHUK(1), DAXX(1), ELK1(2), FOS(1), GRB2(2), IKBKB(1), MAP2K3(1), MAP2K4(1), MAP2K6(1), MAP3K1(1), MAP3K10(2), MAP3K12(1), MAP3K13(2), MAP3K14(1), MAP3K2(2), MAP3K3(1), MAP3K4(2), MAP3K5(2), MAP3K6(1), MAP3K7(3), MAP3K9(1), MAP4K1(1), MAP4K3(3), MAPK14(1), MAPK6(1), MAPK8(1), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MEF2A(1), MEF2C(1), MEF2D(1), MKNK1(1), NFKB1(1), PAK2(1), RELA(1), RPS6KA1(1), RPS6KA2(1), RPS6KA4(1), RPS6KA5(1), RPS6KB2(1), SHC1(1), STAT1(2), TRAF2(1)	39676496	58	56	58	13	6	10	19	15	8	0	0.89	1.00
523	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ARG1(1), GLS(1)	2150366	2	2	2	0	0	0	2	0	0	0	0.89	1.00
524	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(1), GNA12(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	4577268	5	5	5	0	2	0	1	2	0	0	0.89	1.00
525	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(1), ACTG1(2), ARHGEF2(1), CDH1(2), CTNNB1(2), CTTN(1), NCK2(1), PRKCA(1), RHOA(2), TLR4(4), TLR5(1), TUBA3C(3), TUBA4A(3), TUBB1(1), TUBB3(2), TUBB4(2), TUBB8(2), WAS(1)	21643853	32	31	32	10	5	5	11	9	2	0	0.89	1.00
526	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(1), ACTG1(2), ARHGEF2(1), CDH1(2), CTNNB1(2), CTTN(1), NCK2(1), PRKCA(1), RHOA(2), TLR4(4), TLR5(1), TUBA3C(3), TUBA4A(3), TUBB1(1), TUBB3(2), TUBB4(2), TUBB8(2), WAS(1)	21643853	32	31	32	10	5	5	11	9	2	0	0.89	1.00
527	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	57	ATP12A(2), ATP5O(1), ATP6AP1(4), ATP6V0D1(1), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP7B(1), COX10(1), COX6B1(1), NDUFB2(1), NDUFS1(1), PPA2(1), SDHA(1), SHMT1(1), UQCRB(1), UQCRC1(1)	15770684	22	22	21	6	4	0	6	8	4	0	0.90	1.00
528	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	APAF1(2), CASP9(1), DAXX(1), MAPKAPK3(1), TNF(1)	4875061	6	6	6	2	0	2	0	3	1	0	0.90	1.00
529	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACOX1(2), FADS2(2), HADHA(1)	4801514	5	5	5	1	0	0	3	0	2	0	0.90	1.00
530	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	37	ANAPC1(1), ANAPC2(1), ANAPC4(1), ANAPC5(1), BTRC(2), CDC20(1), CDC27(4), CUL2(2), CUL3(1), FBXW11(1), FBXW7(4), SKP2(2), SMURF1(1), UBA1(1)	17226266	23	21	23	4	3	4	5	4	7	0	0.90	1.00
531	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK1(1), HK2(1), HK3(3), ISYNA1(1)	4839654	6	6	6	1	1	2	3	0	0	0	0.90	1.00
532	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	21	GBA(1), GLB1(2), LCT(6), NEU1(1), NEU3(1), PPAP2A(1), SPTLC1(1)	9877930	13	13	13	5	1	2	4	2	4	0	0.90	1.00
533	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	41	BRAF(2), EIF4EBP1(1), FIGF(1), PDPK1(1), PGF(1), PIK3CA(2), PIK3CB(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R5(1), PRKAA2(2), RICTOR(2), RPS6(1), RPS6KA1(1), RPS6KA2(1), RPS6KB2(1), TSC1(3), TSC2(2), ULK2(1), VEGFA(1)	20377950	31	26	31	10	1	7	8	10	5	0	0.90	1.00
534	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM3(1), ELK1(2), FPR1(1), MAP2K3(1), MAP2K6(1), MAP3K1(1), MAPK14(1), NCF2(4), NFATC1(1), NFATC2(1), NFATC4(1), NFKB1(1), PLCB1(4), PPP3CC(1), RELA(1)	16128675	22	22	22	13	5	2	9	6	0	0	0.91	1.00
535	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	CABIN1(2), CALM3(1), HDAC5(1), IGF1R(1), INSR(6), MAP2K6(1), MAPK14(1), MEF2A(1), MEF2C(1), MEF2D(1), NFATC1(1), NFATC2(1), PIK3CA(2), PIK3R1(1), PPP3CC(1)	14026829	22	20	22	13	2	2	9	7	2	0	0.91	1.00
536	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	12	ECHS1(1), EHHADH(2), HADHA(1), HSD17B4(1)	5099472	5	5	5	2	0	0	3	1	1	0	0.91	1.00
537	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C2(1), C3(2), C5(1), C6(2), C7(3), C8A(1)	7917696	10	9	10	3	1	1	2	3	3	0	0.92	1.00
538	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(2), AP2A1(2), BIN1(1), CALM3(1), DNM1(2), PICALM(1), PPP3CC(1), SYNJ1(2)	9559857	12	12	12	8	3	3	2	3	1	0	0.92	1.00
539	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	MARS(2), MARS2(3), METTL6(1), PAPSS2(1), PRMT5(2), PRMT8(3), SCLY(2), SEPHS1(1), WBSCR22(1)	10340611	16	14	16	2	1	1	6	7	1	0	0.92	1.00
540	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK1(1), HK2(1), HK3(3)	4457266	5	5	5	1	1	2	2	0	0	0	0.92	1.00
541	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(2), BIRC3(2), CASP7(1), CASP9(1), PRF1(2), SCAP(1)	7347779	9	9	9	5	0	1	3	4	1	0	0.92	1.00
542	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK2(2), JAK3(3), PTPRU(1)	5903784	6	6	6	2	1	1	1	1	2	0	0.92	1.00
543	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	40	ABP1(2), ALDH1A1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), AOC2(4), AOC3(1), ARG1(1), CPS1(4), MAOA(2), MAOB(1), NOS1(2), NOS3(2), ODC1(1), OTC(1), RARS(1), SMS(1)	18068047	28	25	28	16	1	3	9	9	6	0	0.92	1.00
544	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(1), CALM3(1), ELK1(2), FOS(1), GRB2(2), LYN(1), MAP2K4(1), MAP3K1(1), MAPK8(1), NFATC1(1), NFATC2(1), NFATC4(1), PAK2(1), PIK3CA(2), PIK3R1(1), PLA2G4A(1), PPP3CC(1), SHC1(1), SOS1(3), VAV1(2)	18129539	26	24	26	13	2	6	11	5	2	0	0.92	1.00
545	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C2(1), C3(2), C5(1), C6(2), C7(3), C8A(1), C8B(1), MASP1(1)	9462307	12	11	12	6	2	1	3	3	3	0	0.92	1.00
546	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), ACAT1(2), ACAT2(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), BDH1(1), DDHD1(1), ECHS1(1), EHHADH(2), GAD1(1), GAD2(1), HADHA(1), HMGCS2(1), HSD17B4(1), ILVBL(1), L2HGDH(2), OXCT1(2), PLA1A(1), RDH12(1), RDH13(1)	18026223	28	24	28	10	1	3	10	9	5	0	0.92	1.00
547	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	13	ADSL(1), IMPDH1(1), POLB(1), POLD1(1), POLG(1)	5029639	5	5	5	4	0	3	1	1	0	0	0.93	1.00
548	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	BCR(1), BTK(1), CD19(2), ITPR1(3), ITPR2(5), ITPR3(3), LYN(1), PDK1(1), PIK3CA(2), PITX2(1), PLCG2(1), PREX1(3), PTEN(2), PTPRC(3), RPS6KA1(1), RPS6KA2(1), SAG(1), TEC(1), VAV1(2)	23870337	35	32	35	13	2	4	13	12	4	0	0.93	1.00
549	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	30	ADC(2), CAD(5), CPS1(4), GAD1(1), GAD2(1), GCLM(1), GFPT2(1), GLS(1), GLS2(1), GMPS(2), GSR(2), GSS(3), NADSYN1(1), QARS(1)	17322351	26	23	26	8	4	1	14	3	4	0	0.93	1.00
550	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM3(1), CD3E(2), ELK1(2), FOS(1), GRB2(2), LCK(1), MAP2K4(1), MAP3K1(1), MAPK8(1), NFATC1(1), NFATC2(1), NFATC4(1), NFKB1(1), PIK3CA(2), PIK3R1(1), PPP3CC(1), PRKCA(1), RASA1(1), RELA(1), SHC1(1), SOS1(3), VAV1(2), ZAP70(1)	20322739	30	27	30	15	4	4	14	6	2	0	0.93	1.00
551	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	24	DAG1(3), ITPKB(4), ITPR1(3), ITPR2(5), ITPR3(3), NFKB1(1), PDK1(1), PHKA2(2), PIK3CB(1), PITX2(1), PLD1(1), PLD2(1)	17861744	26	23	26	8	3	2	6	9	6	0	0.93	1.00
552	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(4), CALM3(1), ELK1(2), FOS(1), GNAS(3), NFATC1(1), NFATC2(1), NFATC4(1), PPP3CC(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(1)	14251803	19	19	18	7	7	1	5	4	2	0	0.94	1.00
553	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	25	BLVRA(1), CPOX(1), HMBS(1), PPOX(2), UGT1A10(2), UGT1A3(1), UGT1A5(1), UGT1A7(1), UGT1A8(2), UGT1A9(2), UGT2B4(1)	11531667	15	14	14	7	0	4	3	4	4	0	0.94	1.00
554	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA2(1), ACADM(1), ACAT1(2), ACAT2(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), ALDH7A1(1), AOX1(4), BCAT2(2), ECHS1(1), EHHADH(2), HADHA(1), HMGCS2(1), HSD17B4(1), IVD(2), MCCC2(1), OXCT1(2), PCCB(1)	19343617	29	25	29	12	2	3	8	10	6	0	0.94	1.00
555	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	74	ABL1(1), ANGPTL2(1), ARHGEF7(2), BRAF(2), CSE1L(1), DOCK1(4), EPHB2(1), GRB2(2), GRB7(1), GRLF1(6), ITGA1(1), ITGA10(2), ITGA3(2), ITGA4(3), ITGA5(1), ITGA6(1), ITGA8(3), MAP2K4(1), MAPK8(1), MAPK8IP1(1), MAPK9(1), MRAS(1), MYLK(6), MYLK2(1), PAK2(1), PAK3(5), PAK6(2), PAK7(1), PIK3CA(2), PIK3CB(1), PKLR(1), PLCG2(1), PTEN(2), PTK2(1), SHC1(1), SOS1(3), SOS2(1), SRC(4), TLN1(1), TLN2(3), WAS(1)	51240033	77	70	75	26	8	7	31	18	13	0	0.94	1.00
556	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACAT1(2), ACAT2(1), ADH5(1), AKR1B1(3), ALDH1A1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), DLAT(1), GLO1(2), HAGH(1), LDHB(1), LDHC(1), MDH2(1), ME1(2), ME3(1), PKLR(1)	16020000	23	21	23	11	1	5	9	6	2	0	0.94	1.00
557	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	MEF2A(1), MEF2C(1), MEF2D(1)	3473443	3	3	3	3	0	0	2	1	0	0	0.94	1.00
558	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	JAK2(2), PTPRU(1), STAT1(2)	5026891	5	5	5	1	0	0	3	1	1	0	0.94	1.00
559	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	22	NRF1(1), UBE2J2(1), UBE2M(1)	4179134	3	3	3	2	1	0	0	2	0	0	0.95	1.00
560	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	13	DHCR7(1), HMGCR(1), LSS(1), NQO2(1)	4415379	4	4	4	2	0	1	1	2	0	0	0.95	1.00
561	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACADM(1), ACADSB(2), ACAT1(2), ACAT2(1), ALDH1A1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), ECHS1(1), EHHADH(2), HADHA(1), LDHB(1), LDHC(1), PCCB(1), SUCLG2(1)	14956043	20	18	20	8	2	4	7	4	3	0	0.95	1.00
562	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(3), DARS(1), GARS(1), IARS(1), KARS(1), MARS(2), MARS2(3), QARS(1), RARS(1), TARS(2), WARS(1)	14635826	18	18	18	9	1	3	9	4	1	0	0.95	1.00
563	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	GSK3B(1), PPP2CA(2)	3747407	3	3	3	4	0	0	2	0	1	0	0.95	1.00
564	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	23	CAD(5), CPS1(4), GAD1(1), GAD2(1), GCLM(1), GLS(1), GLS2(1), GMPS(2), GSS(3), NADSYN1(1), QARS(1)	14659618	21	18	21	7	4	1	11	3	2	0	0.95	1.00
565	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(1), GTF2B(1), GTF2E1(1), GTF2H4(1), MNAT1(1), POLR2B(2), POLR2C(1), POLR2I(1), POLR3E(1), TAF12(1), TAF5(1), TAF6(2), TAF9(1), TBP(4)	15442597	19	19	17	12	1	1	6	5	6	0	0.95	1.00
566	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	13	NDUFB2(1), NDUFS1(1)	2959512	2	2	2	1	0	0	0	2	0	0	0.95	1.00
567	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	86	CAPN10(1), CAPN11(1), CAPN5(1), CAPN6(2), CAPN7(1), CAPN9(2), CSK(1), DOCK1(4), GRB2(2), ITGA10(2), ITGA2B(4), ITGA3(2), ITGA4(3), ITGA5(1), ITGA6(1), ITGA8(3), ITGAD(1), ITGAE(1), ITGAL(3), ITGAV(2), ITGAX(1), ITGB2(2), ITGB6(1), ITGB7(4), MAP2K3(1), MAP2K6(1), MAPK6(1), MYLK2(1), PAK2(1), PAK3(5), PAK6(2), PDPK1(1), PIK3R2(2), PTK2(1), PXN(5), RAPGEF1(2), SHC1(1), SORBS1(2), SOS1(3), SRC(4), TLN1(1), TNS1(3), VAV2(4), VAV3(3), VCL(2)	56392190	92	78	89	24	10	7	40	23	12	0	0.96	1.00
568	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM3(1), FOS(1), MAPK14(1), MAPK8(1), PRKCA(1), PTK2B(1)	5889135	6	6	6	3	1	1	2	2	0	0	0.96	1.00
569	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	FADD(1), MAP2K4(1), MAP3K1(1), MAPK8(1), NFKB1(1), NSMAF(1), RELA(1), TNFRSF1A(1), TRAF2(1)	8748649	9	9	9	4	2	3	3	0	1	0	0.96	1.00
570	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	38	CBX3(1), CLOCK(1), CRY1(2), EIF4G2(1), ETV6(1), GFRA1(3), NCKAP1(2), NR1D2(1), PER1(2), PER2(1), PSMA4(1), PURA(1), TOB1(1), TUBB3(2)	15605980	20	19	20	7	1	2	5	9	3	0	0.96	1.00
571	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	5	ACACB(4), MCAT(1)	5589051	5	5	5	3	1	1	3	0	0	0	0.96	1.00
572	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	87	ANK2(8), B3GALT4(2), DGKI(1), PIGK(1), RPL10(1), RPL15(1), RPL32(1), RPLP1(1), RPS18(1), RPS24(1), RPS27A(1), RPS6(1), RPS6KA1(1), RPS6KA2(1), RPS6KB2(1), RPS9(1), SLC36A2(1), TSPAN9(1), UBC(3)	21016616	29	26	29	11	3	5	7	8	6	0	0.96	1.00
573	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	NFKB1(1), PIK3CA(2), PIK3R1(1), PRKCA(1), PTK2(1), PTK2B(1), PXN(5), RELA(1)	11634109	13	13	13	11	3	1	6	1	2	0	0.96	1.00
574	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(1), CALM3(1), CD79A(1), ELK1(2), FOS(1), GRB2(2), LYN(1), MAP3K1(1), MAPK14(1), MAPK8(1), NFATC1(1), NFATC2(1), NFATC4(1), PPP3CC(1), PRKCA(1), SHC1(1), SOS1(3), VAV1(2)	16330030	23	20	23	12	4	4	10	5	0	0	0.97	1.00
575	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	63	MRPL13(1), RPL10A(1), RPL10L(1), RPL23A(1), RPL32(1), RPS18(1), RPS24(1), RPS6(1), RPS9(1)	8328378	9	8	9	6	1	1	3	2	2	0	0.97	1.00
576	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(2), ARFGEF2(1), COPA(1), GPLD1(1), KDELR2(1), KDELR3(1)	7250271	7	7	7	2	0	2	2	3	0	0	0.97	1.00
577	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACB(4), ACAT1(2), ACAT2(1), ACOT12(2), ACSS1(1), AKR1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), DLAT(1), GLO1(2), HAGH(1), LDHAL6B(1), LDHB(1), LDHC(1), MDH2(1), ME1(2), ME3(1), PKLR(1)	20578499	30	27	30	10	2	5	13	8	2	0	0.97	1.00
578	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(1), OPRK1(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	5543576	5	5	5	0	1	0	0	4	0	0	0.97	1.00
579	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	10	ALAS1(1), HMBS(1)	3615635	2	2	2	3	1	0	0	0	1	0	0.97	1.00
580	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHKA(1), SLC18A3(1)	2909171	2	2	2	2	0	0	1	1	0	0	0.97	1.00
581	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	138	ADA(1), ADCY1(4), ADCY2(6), ADCY3(2), ADCY4(1), ADCY5(3), ADCY7(1), ADCY9(5), ADK(1), ADSL(1), ADSSL1(3), AK2(1), AK7(1), ALLC(2), AMPD1(2), AMPD2(2), AMPD3(1), ATIC(2), DCK(1), ENPP1(2), ENPP3(2), ENTPD1(2), ENTPD3(1), ENTPD5(1), GART(3), GDA(1), GMPR2(3), GMPS(2), GUCY1A3(1), GUCY2C(3), IMPDH1(1), ITPA(1), NPR1(1), NPR2(2), NT5C1A(1), NT5C1B(1), NT5C3(1), NT5E(2), NUDT5(1), PAPSS2(1), PDE10A(3), PDE11A(4), PDE1A(1), PDE2A(2), PDE4A(2), PDE4C(1), PDE6H(1), PDE7B(1), PDE8A(1), PFAS(2), PKLR(1), POLA1(2), POLD1(1), POLD2(2), POLD3(1), POLE(2), POLE2(1), POLR1C(1), POLR2B(2), POLR2C(1), POLR2I(1), PRPS1L1(2), PRUNE(1), RRM2B(2), XDH(1)	71181527	112	92	110	39	19	11	35	29	18	0	0.98	1.00
582	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	83	AICDA(1), AK3(2), CAD(5), CDA(1), CTPS2(1), DCK(1), DCTD(1), DHODH(1), DPYD(3), DPYS(1), ENTPD1(2), ENTPD3(1), ENTPD5(1), ITPA(1), NT5C1A(1), NT5C1B(1), NT5C3(1), NT5E(2), POLA1(2), POLD1(1), POLD2(2), POLD3(1), POLE(2), POLE2(1), POLR1C(1), POLR2B(2), POLR2C(1), POLR2I(1), RRM2B(2), TXNRD2(2), UCK2(1), UMPS(1), UPB1(1), UPP1(1)	35265960	49	45	49	19	10	1	15	14	9	0	0.98	1.00
583	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	34	ENPP7(1), GBA(1), GLB1(2), LCT(6), NEU1(1), NEU3(1), PPAP2A(1), SGPP2(1), SMPD3(1), SPHK1(1), SPTLC1(1)	13767639	17	16	17	8	2	2	5	4	4	0	0.98	1.00
584	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACB(4), ACADM(1), ACAT1(2), ACAT2(1), ACSS1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), ALDH7A1(1), ECHS1(1), EHHADH(2), HADHA(1), LDHAL6B(1), LDHB(1), LDHC(1), PCCB(1), SUCLG2(1)	17990102	24	21	24	7	3	3	9	6	3	0	0.98	1.00
585	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ARPC1A(1), ARPC3(1)	3634055	2	2	2	0	0	1	1	0	0	0	0.98	1.00
586	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	NRG2(1), PRKCA(1)	4037719	2	2	2	1	1	0	1	0	0	0	0.98	1.00
587	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP2(1), RECK(1)	3292425	2	2	2	3	0	0	1	1	0	0	0.98	1.00
588	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	13	POLR2B(2), POLR2C(1), POLR2I(1)	5129945	4	4	4	1	0	1	0	2	1	0	0.98	1.00
589	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(3), EP300(1), NOS3(2)	7058354	6	6	6	3	0	0	2	3	1	0	0.98	1.00
590	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1)	3303680	1	1	1	0	0	0	0	0	1	0	0.98	1.00
591	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(2), ACO2(1), CS(1), DLST(1), FH(1), MDH2(1), SDHA(1), SUCLG2(1)	8979632	9	9	9	3	0	1	3	3	2	0	0.98	1.00
592	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(2), POLB(1), POLD1(1), POLD2(2), POLD3(1), POLE(2), POLE2(1), POLG(1), POLI(2), POLK(1), POLM(2), POLQ(3), REV3L(1)	18375351	20	20	20	11	3	3	10	3	1	0	0.98	1.00
593	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM3(1), CHUK(1), MAP3K1(1), NFATC1(1), NFATC2(1), NFKB1(1), PPP3CC(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RELA(1), VIPR2(1)	11532660	12	12	12	9	4	1	2	5	0	0	0.99	1.00
594	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	CPT1A(2), LEPR(1), PRKAA2(2)	6628783	5	5	5	2	0	0	2	2	1	0	0.99	1.00
595	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	23	DHCR7(1), GGCX(1), GGPS1(1), HMGCR(1), IDI2(1), LSS(1), TM7SF2(1)	8031604	7	7	7	3	0	1	3	2	1	0	0.99	1.00
596	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDOC(1), DLAT(1), G6PC(1), GPI(2), HK1(1), HK2(1), HK3(3), LDHB(1), LDHC(1), PFKP(2), PGK1(2), PKLR(1)	21325915	27	25	27	12	3	6	10	5	3	0	0.99	1.00
597	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDOC(1), DLAT(1), G6PC(1), GPI(2), HK1(1), HK2(1), HK3(3), LDHB(1), LDHC(1), PFKP(2), PGK1(2), PKLR(1)	21325915	27	25	27	12	3	6	10	5	3	0	0.99	1.00
598	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	30	ARG1(1), ASS1(1), CPS1(4), NOS1(2), NOS3(2), OTC(1), PARS2(1), RARS(1), RARS2(2)	14373303	15	15	15	14	0	2	7	4	2	0	0.99	1.00
599	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(2), CALM3(1), EP300(1), HDAC1(1), MEF2D(1), NFATC1(1), NFATC2(1), PPP3CC(1), PRKCA(1)	10151543	10	9	10	6	3	1	3	1	2	0	0.99	1.00
600	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	INPP1(1), INPP4A(1), INPP4B(1), INPPL1(1), IPMK(1), ISYNA1(1), ITPK1(1), ITPKB(4), OCRL(1), PI4KA(1), PI4KB(2), PIK3CA(2), PIK3CB(1), PIK3CG(3), PIP4K2A(1), PIP4K2B(1), PIP5K1A(1), PIP5K1C(1), PLCB1(4), PLCB2(4), PLCB3(2), PLCB4(1), PLCD4(2), PLCE1(1), PLCG2(1), PLCZ1(1), PTEN(2), SYNJ1(2)	30169383	45	36	45	13	3	10	15	14	3	0	0.99	1.00
601	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM3(1), CDKN1A(1), NFATC1(1), NFATC2(1), NFATC4(1), PPP3CC(1), PRKCA(1)	8634058	7	7	7	8	3	1	2	1	0	0	0.99	1.00
602	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	14	DHCR7(1), HMGCR(1), LSS(1)	5387432	3	3	3	2	0	1	1	1	0	0	0.99	1.00
603	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(3), ACO1(2), ACO2(1), CS(1), DLST(1), FH(1), MDH2(1), OGDH(2), SDHA(1), SUCLG2(1)	13147823	14	14	14	4	0	2	6	4	2	0	0.99	1.00
604	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	32	ARHGEF11(2), DLG4(2), LPA(2), MAP2K4(1), MAP3K1(1), MAP3K5(2), MAPK8(1), NFKB1(1), PDK1(1), PHKA2(2), PIK3CB(1), PLD1(1), PLD2(1), PTK2(1), SERPINA4(2), SRF(1)	20312243	22	20	22	13	5	4	5	2	6	0	1.00	1.00
605	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	62	ACSS1(1), ADH1B(1), ADH1C(1), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDOC(1), DLAT(1), G6PC(1), GPI(2), HK1(1), HK2(1), HK3(3), LDHAL6B(1), LDHB(1), LDHC(1), PFKP(2), PGK1(2), PGK2(1), PKLR(1)	24603708	31	28	31	10	3	5	12	7	4	0	1.00	1.00
606	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(1)	4641740	1	1	1	3	0	0	1	0	0	0	1.00	1.00
607	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	42	ALDOC(1), DLAT(1), G6PC(1), GPI(2), HK1(1), HK2(1), HK3(3), LDHAL6B(1), LDHB(1), LDHC(1), MDH2(1), PFKP(2), PGK1(2), PGK2(1), PKLR(1)	17596225	20	19	20	8	3	3	10	3	1	0	1.00	1.00
608	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), CS(1), DLAT(1), DLST(1), FH(1), MDH2(1), OGDH(2), PDK1(1), PDK3(1), SDHA(1), SUCLG2(1)	12416313	12	11	12	7	1	2	5	3	1	0	1.00	1.00
609	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	89	CD2BP2(1), CLK4(1), COL2A1(1), CPSF2(2), CSTF2T(1), DDIT3(2), DDX1(1), DHX15(1), DHX16(3), DHX8(2), DHX9(2), DICER1(1), NONO(1), NXF1(1), PABPN1(2), PRPF3(1), PRPF4(1), PRPF4B(1), PRPF8(1), PTBP1(1), RNPS1(2), SF3A1(4), SF3B2(1), SF3B4(2), SNRPA(1), SNRPB(1), SNRPN(1), SPOP(1), SRPK1(1), SRPK2(1), SRRM1(2), SUPT5H(4), U2AF2(1), XRN2(1)	46105882	50	45	50	14	7	10	14	9	10	0	1.00	1.00
610	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1C(1), POLR2B(2), POLR2C(1), POLR2I(1)	10380306	5	5	5	6	0	1	0	3	1	0	1.00	1.00
611	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		339344	0	0	0	1	0	0	0	0	0	0	1.00	1.00
612	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		237871	0	0	0	0	0	0	0	0	0	0	1.00	1.00
613	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3		715548	0	0	0	0	0	0	0	0	0	0	1.00	1.00
614	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5		1999361	0	0	0	1	0	0	0	0	0	0	1.00	1.00
615	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6		1679841	0	0	0	0	0	0	0	0	0	0	1.00	1.00
616	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4		1409820	0	0	0	1	0	0	0	0	0	0	1.00	1.00