Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.049 0.045 0.149 18.0 -9999.0 0.0 18.0 KIRREL 0.041 0.017 0.084 2.0 -0.037 2.0 4.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.049 0.045 -9999.0 0.0 -0.15 18.0 18.0 PLCG1 0.038 0.012 -9999.0 0.0 0.0 50.0 50.0 ARRB2 0.039 0.011 -9999.0 0.0 0.0 44.0 44.0 WASL 0.04 0.009 -9999.0 0.0 0.0 24.0 24.0 Nephrin/NEPH1/podocin/CD2AP 0.073 0.071 -9999.0 0.0 -0.117 41.0 41.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.031 0.057 -9999.0 0.0 -0.143 31.0 31.0 FYN 0.003 0.065 0.17 60.0 -0.182 3.0 63.0 mol:Ca2+ 0.075 0.064 -9999.0 0.0 -0.129 25.0 25.0 mol:DAG 0.077 0.065 -9999.0 0.0 -0.129 25.0 25.0 NPHS2 0.043 0.02 -9999.0 0.0 -0.043 19.0 19.0 mol:IP3 0.077 0.065 -9999.0 0.0 -0.129 25.0 25.0 regulation of endocytosis 0.053 0.059 -9999.0 0.0 -0.12 20.0 20.0 Nephrin/NEPH1/podocin/Cholesterol 0.064 0.048 0.183 1.0 -0.111 18.0 19.0 establishment of cell polarity 0.049 0.045 -9999.0 0.0 -0.149 18.0 18.0 Nephrin/NEPH1/podocin/NCK1-2 0.086 0.078 -9999.0 0.0 -0.112 38.0 38.0 Nephrin/NEPH1/beta Arrestin2 0.056 0.06 -9999.0 0.0 -0.121 20.0 20.0 NPHS1 0.04 0.022 0.084 5.0 -0.044 17.0 22.0 Nephrin/NEPH1/podocin 0.055 0.056 0.218 1.0 -0.124 19.0 20.0 TJP1 0.037 0.013 -9999.0 0.0 0.0 64.0 64.0 NCK1 0.036 0.015 -9999.0 0.0 0.0 80.0 80.0 NCK2 0.042 0.004 -9999.0 0.0 0.0 6.0 6.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.078 0.066 -9999.0 0.0 -0.129 25.0 25.0 CD2AP 0.037 0.014 -9999.0 0.0 0.0 67.0 67.0 Nephrin/NEPH1/podocin/GRB2 0.085 0.059 -9999.0 0.0 -0.122 18.0 18.0 GRB2 0.041 0.007 -9999.0 0.0 0.0 17.0 17.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.005 0.071 0.174 67.0 -0.123 3.0 70.0 cytoskeleton organization 0.013 0.054 0.25 4.0 -0.158 14.0 18.0 Nephrin/NEPH1 0.042 0.034 -9999.0 0.0 -0.096 18.0 18.0 Nephrin/NEPH1/ZO-1 0.055 0.062 -9999.0 0.0 -0.132 37.0 37.0