Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.003 0.219 -9999.0 0.0 -0.806 4.0 4.0 IHH 0.0 0.107 -9999.0 0.0 -0.585 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.113 0.154 -9999.0 0.0 -0.35 14.0 14.0 LRPAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.112 0.152 0.348 14.0 -9999.0 0.0 14.0 SMO/beta Arrestin2 -0.013 0.149 -9999.0 0.0 -0.486 3.0 3.0 SMO -0.017 0.145 -9999.0 0.0 -0.512 2.0 2.0 AKT1 0.011 0.073 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.007 0.07 -9999.0 0.0 -0.569 1.0 1.0 BOC 0.004 0.066 -9999.0 0.0 -0.378 2.0 2.0 ADRBK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.017 0.144 -9999.0 0.0 -0.504 2.0 2.0 STIL -0.009 0.124 -9999.0 0.0 -0.404 1.0 1.0 DHH N/PTCH2 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.019 0.109 -9999.0 0.0 -0.377 2.0 2.0 PIK3CA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.014 0.267 -9999.0 0.0 -0.968 4.0 4.0 determination of left/right symmetry -0.017 0.144 -9999.0 0.0 -0.504 2.0 2.0 PIK3R1 0.01 0.047 -9999.0 0.0 -0.378 1.0 1.0 skeletal system development -0.013 0.262 -9999.0 0.0 -0.949 4.0 4.0 IHH N/Hhip -0.073 0.198 -9999.0 0.0 -0.436 15.0 15.0 DHH N/Hhip -0.058 0.163 -9999.0 0.0 -0.376 14.0 14.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.017 0.144 -9999.0 0.0 -0.504 2.0 2.0 pancreas development -0.095 0.221 -9999.0 0.0 -0.528 14.0 14.0 HHAT -0.036 0.155 -9999.0 0.0 -0.487 7.0 7.0 PI3K 0.019 0.033 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.164 0.23 -9999.0 0.0 -0.442 27.0 27.0 somite specification -0.017 0.144 -9999.0 0.0 -0.504 2.0 2.0 SHH Np/Cholesterol/PTCH1 -0.014 0.13 -9999.0 0.0 -0.362 3.0 3.0 SHH Np/Cholesterol/PTCH2 -0.015 0.109 -9999.0 0.0 -0.347 5.0 5.0 SHH Np/Cholesterol/Megalin -0.018 0.11 -9999.0 0.0 -0.347 5.0 5.0 SHH -0.03 0.14 -9999.0 0.0 -0.352 10.0 10.0 catabolic process 0.012 0.122 -9999.0 0.0 -0.397 3.0 3.0 SMO/Vitamin D3 -0.025 0.149 -9999.0 0.0 -0.516 2.0 2.0 SHH Np/Cholesterol/Hhip -0.077 0.169 -9999.0 0.0 -0.355 15.0 15.0 LRP2 0.01 0.047 -9999.0 0.0 -0.378 1.0 1.0 receptor-mediated endocytosis -0.016 0.149 -9999.0 0.0 -0.444 3.0 3.0 SHH Np/Cholesterol/BOC -0.021 0.112 -9999.0 0.0 -0.347 5.0 5.0 SHH Np/Cholesterol/CDO -0.015 0.109 -9999.0 0.0 -0.347 5.0 5.0 mesenchymal cell differentiation 0.077 0.168 0.352 15.0 -9999.0 0.0 15.0 mol:Vitamin D3 -0.011 0.132 -9999.0 0.0 -0.362 3.0 3.0 IHH N/PTCH2 0.014 0.065 -9999.0 0.0 -0.347 2.0 2.0 CDON 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.013 0.124 -9999.0 0.0 -0.4 3.0 3.0 Megalin/LRPAP1 0.019 0.033 -9999.0 0.0 -0.252 1.0 1.0 PTCH2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.025 0.108 -9999.0 0.0 -0.355 5.0 5.0 PTCH1 0.012 0.123 -9999.0 0.0 -0.399 3.0 3.0 HHIP -0.095 0.221 -9999.0 0.0 -0.528 14.0 14.0