Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.002 0.158 -9999.0 0.0 -0.873 2.0 2.0 IHH 0.023 0.092 -9999.0 0.0 -0.474 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.017 0.114 0.172 1.0 -0.249 13.0 14.0 LRPAP1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.018 0.114 0.248 13.0 -0.17 1.0 14.0 SMO/beta Arrestin2 0.005 0.118 -9999.0 0.0 -0.328 6.0 6.0 SMO -0.008 0.112 -9999.0 0.0 -0.332 7.0 7.0 AKT1 -0.018 0.148 -9999.0 0.0 -0.401 7.0 7.0 ARRB2 0.019 0.058 -9999.0 0.0 -0.442 1.0 1.0 BOC 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.008 0.111 -9999.0 0.0 -0.328 7.0 7.0 STIL -0.004 0.101 0.187 4.0 -0.235 9.0 13.0 DHH N/PTCH2 0.048 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.02 0.083 -9999.0 0.0 -0.309 4.0 4.0 PIK3CA 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.015 0.203 -9999.0 0.0 -0.735 4.0 4.0 determination of left/right symmetry -0.008 0.111 -9999.0 0.0 -0.328 7.0 7.0 PIK3R1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.015 0.199 -9999.0 0.0 -0.724 4.0 4.0 IHH N/Hhip -0.02 0.164 -9999.0 0.0 -0.371 12.0 12.0 DHH N/Hhip -0.01 0.135 -9999.0 0.0 -0.319 11.0 11.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.008 0.111 -9999.0 0.0 -0.328 7.0 7.0 pancreas development -0.042 0.174 -9999.0 0.0 -0.441 11.0 11.0 HHAT 0.006 0.112 -9999.0 0.0 -0.442 4.0 4.0 PI3K 0.048 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.02 0.165 -9999.0 0.0 -0.442 9.0 9.0 somite specification -0.008 0.111 -9999.0 0.0 -0.328 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.012 0.091 -9999.0 0.0 -0.242 9.0 9.0 SHH Np/Cholesterol/PTCH2 0.009 0.073 -9999.0 0.0 -0.249 5.0 5.0 SHH Np/Cholesterol/Megalin 0.009 0.073 -9999.0 0.0 -0.249 5.0 5.0 SHH -0.037 0.08 -9999.0 0.0 -0.322 5.0 5.0 catabolic process -0.0 0.087 -9999.0 0.0 -0.343 4.0 4.0 SMO/Vitamin D3 -0.015 0.11 -9999.0 0.0 -0.327 5.0 5.0 SHH Np/Cholesterol/Hhip -0.034 0.124 -9999.0 0.0 -0.263 15.0 15.0 LRP2 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.019 0.11 -9999.0 0.0 -0.295 7.0 7.0 SHH Np/Cholesterol/BOC 0.009 0.073 -9999.0 0.0 -0.249 5.0 5.0 SHH Np/Cholesterol/CDO 0.008 0.073 -9999.0 0.0 -0.249 5.0 5.0 mesenchymal cell differentiation 0.034 0.123 0.262 15.0 -9999.0 0.0 15.0 mol:Vitamin D3 -0.001 0.105 0.19 5.0 -0.242 9.0 14.0 IHH N/PTCH2 0.041 0.061 -9999.0 0.0 -0.283 2.0 2.0 CDON 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.02 0.092 -9999.0 0.0 -0.345 4.0 4.0 Megalin/LRPAP1 0.049 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.002 0.069 -9999.0 0.0 -0.245 5.0 5.0 PTCH1 -0.0 0.087 -9999.0 0.0 -0.344 4.0 4.0 HHIP -0.042 0.175 -9999.0 0.0 -0.442 11.0 11.0