Clinical Features Time to Death AGE GENDER HISTOLOGICAL.TYPE PATHOLOGY.T PATHOLOGY.N PATHOLOGICSPREAD(M) TUMOR.STAGE NEOADJUVANT.THERAPY nMutated (%) nWild-Type logrank test_P logrank test_Q t-test_P t-test_Q Fisher's exact test_P Fisher's exact test_Q Chi-square test_P Chi-square test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q ACVR2A 17 (13%) 115 0.0015469 1 0.099169 1 0.11444 1 0.18027 1 0.15049 1 1 1 0.52891 1 0.78673 1 0.59551 1 CBWD1 17 (13%) 115 0.30281 1 0.020781 1 0.29391 1 0.2975 1 0.00089984 0.677 0.53977 1 0.52891 1 0.40761 1 0.59551 1 DNAJC15 3 (2%) 129 NA NA 0.029133 1 0.56416 1 0.81024 1 1 1 NA NA 0.11354 1 NA NA 1 1 KRAS 17 (13%) 115 0.35301 1 0.24114 1 0.11444 1 0.66785 1 0.81134 1 0.50221 1 0.64487 1 0.33903 1 0.59551 1 RPL22 10 (8%) 122 0.47763 1 0.018571 1 0.52156 1 0.61311 1 0.058759 1 0.23511 1 0.00092781 0.697 0.081114 1 1 1 SFRS12IP1 5 (4%) 127 NA NA 0.0016734 1 0.64771 1 0.78224 1 0.23632 1 0.60594 1 1 1 0.36812 1 1 1 SMAP1 5 (4%) 127 NA NA 0.076758 1 0.39026 1 0.78224 1 0.031743 1 0.60594 1 1 1 0.13203 1 1 1 TP53 61 (46%) 71 0.082625 1 0.71424 1 0.28531 1 0.053281 1 0.75917 1 0.90782 1 0.12807 1 0.75095 1 0.47017 1 TRIM48 14 (11%) 118 0.32198 1 0.1201 1 0.56557 1 0.29889 1 0.098247 1 0.30413 1 0.08737 1 0.16604 1 0.59916 1 ZNF48 3 (2%) 129 NA NA 0.076341 1 0.56416 1 0.95324 1 0.15078 1 NA NA 1 1 NA NA 1 1 PGM5 18 (14%) 114 0.96205 1 0.00066872 0.504 0.019151 1 0.50471 1 0.0071418 1 0.58405 1 0.55125 1 0.41334 1 1 1 ARID1A 26 (20%) 106 0.22514 1 0.8905 1 0.27174 1 0.26773 1 0.16213 1 0.30305 1 0.017749 1 0.11809 1 0.65591 1 RHOA 7 (5%) 125 0.096845 1 0.072079 1 0.70134 1 0.35807 1 0.54088 1 0.71833 1 0.62823 1 0.20282 1 0.36127 1 PIK3CA 25 (19%) 107 0.40676 1 0.59122 1 0.37667 1 0.77421 1 0.72204 1 0.63032 1 0.87929 1 0.40528 1 1 1 INO80E 9 (7%) 123 0.67686 1 0.33847 1 0.15582 1 0.69396 1 0.00081907 0.617 0.19883 1 0.19179 1 0.12204 1 1 1 FGF22 4 (3%) 128 NA NA 0.013222 1 1 1 0.69149 1 0.28765 1 0.84266 1 0.42784 1 1 1 1 1 OR8H3 10 (8%) 122 0.62582 1 0.38639 1 0.73917 1 0.028165 1 0.73077 1 0.06777 1 0.70705 1 0.70512 1 0.47709 1 ZNF804B 21 (16%) 111 0.90869 1 0.2378 1 0.62879 1 0.42746 1 1 1 0.073379 1 0.39545 1 0.012845 1 1 1 CDH1 13 (10%) 119 0.51575 1 0.14793 1 1 1 0.14197 1 0.68119 1 0.8187 1 1 1 0.37763 1 1 1 TUSC3 11 (8%) 121 0.76027 1 0.57539 1 1 1 0.78588 1 0.60593 1 0.4569 1 0.35595 1 0.55158 1 0.51138 1 PRRT2 5 (4%) 127 NA NA 0.27687 1 1 1 0.57118 1 0.0029123 1 0.41754 1 0.21327 1 NA NA 1 1 PTH2 3 (2%) 129 NA NA 0.83298 1 0.56416 1 0.75553 1 1 1 0.41754 1 1 1 0.77384 1 0.17225 1 C17ORF63 4 (3%) 128 NA NA 0.80609 1 1 1 0.90677 1 0.27342 1 0.70516 1 1 1 0.52587 1 1 1 IAPP 4 (3%) 128 NA NA 0.46116 1 0.64862 1 0.90677 1 1 1 0.8866 1 0.16219 1 0.13203 1 1 1 IRF2 8 (6%) 124 0.74044 1 0.20851 1 0.059674 1 0.8726 1 0.018606 1 0.86977 1 0.25029 1 1 1 1 1 RNF43 15 (11%) 117 0.025684 1 0.013677 1 0.27918 1 0.15379 1 0.095549 1 0.97042 1 0.49031 1 0.19898 1 0.59601 1 HLA-B 10 (8%) 122 0.96326 1 0.47349 1 0.088568 1 0.53268 1 0.15788 1 0.11431 1 0.32034 1 0.29981 1 1 1 HLA-A 9 (7%) 123 0.35438 1 0.98527 1 0.48322 1 0.11716 1 0.60317 1 0.78266 1 0.69692 1 0.95185 1 0.44072 1 SMAD4 8 (6%) 124 0.10336 1 0.043008 1 1 1 0.66563 1 0.89823 1 1 1 0.15511 1 0.95185 1 1 1 UPF3A 7 (5%) 125 0.64682 1 0.12989 1 0.43781 1 0.86447 1 0.001395 1 0.58915 1 0.21627 1 0.25434 1 1 1 CCDC43 4 (3%) 128 NA NA 0.25199 1 1 1 0.69149 1 0.42763 1 0.79021 1 1 1 0.162 1 1 1 PHF2 13 (10%) 119 0.90489 1 0.0061659 1 0.37393 1 0.43458 1 0.011951 1 0.58999 1 0.0034094 1 0.10147 1 1 1 PCDH15 23 (17%) 109 0.85494 1 0.80236 1 0.48465 1 0.79657 1 0.28472 1 0.71434 1 0.53296 1 0.20358 1 0.62783 1 SPRYD5 8 (6%) 124 0.14313 1 0.12562 1 1 1 0.92527 1 0.05087 1 0.71833 1 0.075654 1 0.029253 1 1 1 SOX1 6 (5%) 126 0.36089 1 0.44438 1 1 1 0.93517 1 0.18739 1 0.086475 1 1 1 0.52587 1 0.31796 1 POTEG 6 (5%) 126 0.22058 1 0.0096299 1 0.68377 1 0.55798 1 0.62945 1 0.58915 1 1 1 0.80347 1 1 1 TPTE 16 (12%) 116 0.382 1 0.58688 1 0.42398 1 0.0041643 1 0.28844 1 0.68454 1 0.5084 1 1 1 1 1 FSHR 14 (11%) 118 0.55023 1 0.03217 1 0.56557 1 0.12322 1 0.047957 1 0.63721 1 0.76804 1 0.56613 1 1 1 UNC93B1 3 (2%) 129 NA NA 0.0016671 1 0.56416 1 0.59878 1 NA NA 0.19977 1 1 1 NA NA 1 1 EDNRB 12 (9%) 120 0.8774 1 0.76188 1 0.54273 1 0.29493 1 0.25324 1 0.42648 1 0.39165 1 0.85891 1 1 1 RASA1 10 (8%) 122 0.30695 1 0.23129 1 1 1 0.19878 1 0.019487 1 0.72287 1 0.087834 1 0.37078 1 0.47709 1 KDM4B 11 (8%) 121 0.80969 1 0.033579 1 0.027274 1 0.43216 1 0.15788 1 0.82504 1 0.35595 1 0.53331 1 1 1 LHCGR 7 (5%) 125 0.86269 1 0.40304 1 1 1 0.70055 1 0.086563 1 0.38961 1 0.21627 1 1 1 0.36127 1 TM7SF4 8 (6%) 124 0.91498 1 0.32062 1 1 1 0.86004 1 0.77138 1 0.82504 1 1 1 0.67899 1 1 1 IL2RG 3 (2%) 129 NA NA 0.44821 1 0.062526 1 0.95324 1 1 1 NA NA 0.11354 1 NA NA 1 1 TLR4 13 (10%) 119 0.29508 1 0.94615 1 0.56102 1 0.38397 1 0.39252 1 0.70231 1 0.4272 1 1 1 0.17864 1 TSHZ2 7 (5%) 125 0.20535 1 0.61879 1 0.43781 1 0.53803 1 0.60317 1 0.021 1 0.31785 1 0.048211 1 1 1 PDZRN4 12 (9%) 120 0.69886 1 0.99361 1 0.35988 1 0.93495 1 0.13614 1 0.82663 1 0.059144 1 0.90888 1 0.54369 1 POM121L12 8 (6%) 124 0.94269 1 0.5017 1 0.71328 1 0.57742 1 0.11845 1 0.81671 1 0.15511 1 0.29501 1 1 1 WBSCR17 12 (9%) 120 0.11617 1 0.16515 1 0.54273 1 0.2385 1 0.52124 1 1 1 0.19903 1 0.74416 1 1 1 ZC4H2 6 (5%) 126 0.30294 1 0.87414 1 1 1 0.81 1 0.27342 1 0.1507 1 0.17174 1 0.055399 1 1 1 CNBD1 6 (5%) 126 NA NA 0.049781 1 0.68377 1 0.77614 1 1 1 1 1 1 1 0.33817 1 0.31796 1 CPS1 14 (11%) 118 0.86205 1 0.77332 1 0.15835 1 0.53522 1 0.62599 1 0.53909 1 0.18988 1 0.97265 1 0.59916 1 KIAA0748 8 (6%) 124 0.3374 1 0.23703 1 1 1 0.75513 1 0.69006 1 0.51589 1 1 1 0.1398 1 1 1 OR2T6 7 (5%) 125 0.99613 1 0.96162 1 1 1 0.55798 1 0.0689 1 0.38961 1 0.62823 1 0.083655 1 0.36127 1 CHRM2 7 (5%) 125 NA NA 0.60668 1 0.24132 1 0.10434 1 0.466 1 0.91237 1 1 1 0.11843 1 0.36127 1 NDN 8 (6%) 124 0.1483 1 0.8274 1 0.26634 1 0.72585 1 0.60317 1 0.71859 1 1 1 0.95185 1 1 1 TCEB3C 5 (4%) 127 0.94522 1 0.67954 1 1 1 0.84587 1 0.87463 1 0.17196 1 0.50383 1 0.33925 1 0.27211 1 IL13RA2 7 (5%) 125 0.16084 1 0.32037 1 0.43781 1 0.56106 1 0.18739 1 0.38961 1 0.62823 1 0.65769 1 0.058139 1 ASTN2 16 (12%) 116 0.52514 1 0.081745 1 0.18198 1 0.17208 1 0.10982 1 1 1 0.22781 1 0.84989 1 1 1 FCRL3 9 (7%) 123 0.51511 1 0.96328 1 0.48322 1 0.91276 1 0.33248 1 0.42116 1 1 1 0.88214 1 1 1 PARK2 9 (7%) 123 0.72987 1 0.0079811 1 0.73987 1 0.12014 1 0.23773 1 0.47196 1 0.19179 1 0.1398 1 0.44072 1 POU3F2 4 (3%) 128 NA NA 0.46076 1 0.14859 1 0.81024 1 0.57072 1 0.41754 1 0.16219 1 1 1 1 1 FAM9A 6 (5%) 126 0.67686 1 0.24859 1 0.68377 1 0.81 1 0.0069672 1 0.17536 1 0.0055857 1 0.12204 1 1 1 CSNK2A1 4 (3%) 128 0.46512 1 0.68406 1 0.64862 1 0.34832 1 0.82113 1 1 1 1 1 0.20746 1 0.22359 1 CAPN6 7 (5%) 125 NA NA 0.39932 1 1 1 0.91939 1 0.097033 1 0.55774 1 0.12077 1 1 1 1 1 ELF3 6 (5%) 126 0.54055 1 0.39066 1 0.21838 1 0.44426 1 0.44142 1 0.3657 1 1 1 0.93476 1 1 1 FBXW7 10 (8%) 122 0.87627 1 0.073704 1 0.52156 1 0.61904 1 1 1 0.31284 1 0.22178 1 0.76763 1 1 1 TP53TG5 4 (3%) 128 0.73946 1 0.73544 1 0.64862 1 0.021692 1 0.060741 1 0.39525 1 1 1 0.52587 1 1 1 ZNF559 7 (5%) 125 0.18374 1 0.54212 1 0.11632 1 0.45897 1 0.036843 1 0.65002 1 0.62823 1 0.099925 1 1 1 CHRM3 6 (5%) 126 0.49731 1 0.059185 1 0.68377 1 0.45897 1 0.27086 1 0.46563 1 0.26551 1 0.69513 1 1 1 ELL2 8 (6%) 124 0.56714 1 0.3957 1 1 1 0.75513 1 0.15707 1 0.4394 1 0.25029 1 0.85865 1 1 1 EPHA6 14 (11%) 118 0.32246 1 0.39723 1 0.78127 1 0.30157 1 0.17457 1 0.47788 1 0.46238 1 0.3828 1 1 1 OSGIN2 6 (5%) 126 0.32876 1 0.63919 1 0.21838 1 0.74846 1 0.34887 1 0.76563 1 0.08938 1 0.7088 1 1 1 KRTAP4-1 3 (2%) 129 0.29087 1 0.6174 1 0.56416 1 0.75175 1 1 1 0.29616 1 1 1 0.87822 1 1 1 SMAD2 7 (5%) 125 0.386 1 0.23784 1 0.43781 1 0.57118 1 0.69006 1 0.50956 1 0.62823 1 0.7088 1 1 1 ANAPC1 12 (9%) 120 0.7108 1 0.0001349 0.102 0.76164 1 0.76693 1 0.14364 1 0.7183 1 0.39165 1 0.90888 1 1 1 EDIL3 6 (5%) 126 0.93127 1 0.8768 1 0.21838 1 0.78224 1 0.34887 1 0.55774 1 0.57024 1 0.33298 1 1 1 OR4C13 5 (4%) 127 0.74766 1 0.71321 1 0.39026 1 0.74107 1 0.82113 1 1 1 1 1 0.48246 1 1 1 OR4C16 9 (7%) 123 0.61435 1 0.20436 1 0.73987 1 0.25716 1 0.41428 1 0.44102 1 0.69692 1 0.84838 1 1 1 PRR11 4 (3%) 128 NA NA 0.48252 1 1 1 0.7865 1 0.031743 1 0.79021 1 0.16219 1 0.33817 1 1 1 AUH 5 (4%) 127 NA NA 0.006586 1 0.39026 1 0.8899 1 0.23632 1 0.8866 1 0.21327 1 0.87822 1 1 1 AFAP1 5 (4%) 127 0.33044 1 0.76006 1 1 1 0.94578 1 0.057287 1 0.70748 1 0.061612 1 0.29512 1 1 1 LIN7A 6 (5%) 126 0.47107 1 0.91439 1 0.68377 1 0.86907 1 0.32698 1 0.91237 1 1 1 0.33925 1 0.31796 1 OR8B4 3 (2%) 129 0.54055 1 0.75829 1 0.56416 1 0.26879 1 0.28765 1 0.098006 1 1 1 0.33817 1 0.17225 1 PID1 5 (4%) 127 0.36089 1 0.62383 1 0.64771 1 0.16059 1 0.58265 1 0.1277 1 0.21327 1 0.13203 1 1 1 AVP 3 (2%) 129 NA NA 0.36215 1 1 1 0.95324 1 1 1 1 1 0.019618 1 1 1 1 1