rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(17), CDC25A(2), CDC25B(4), CDC25C(3), CDK2(2), CHEK1(2), MYT1(12), RB1(8), TP53(67), WEE1(1), YWHAH(1) 3508527 119 78 98 12 37 31 5 16 28 2 4.44e-06 <1.00e-15 <1.54e-13 2 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(2), CCND1(1), CDK2(2), CDKN1A(1), CDKN2A(4), CFL1(1), E2F2(2), MDM2(3), NXT1(2), PRB1(2), TP53(67) 1604627 87 72 68 11 27 21 3 12 23 1 0.00016 <1.00e-15 <1.54e-13 3 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 DNAJC3(1), EIF2S1(1), EIF2S2(2), MAP3K14(3), NFKB1(5), RELA(2), TP53(67) 1951817 81 67 62 7 24 16 2 16 22 1 0.00014 <1.00e-15 <1.54e-13 4 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(2), MAX(1), SP1(3), SP3(3), TP53(67), WT1(1) 1390783 77 67 58 9 24 17 2 11 22 1 0.000094 <1.00e-15 <1.54e-13 5 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(17), ATR(5), CDC25C(3), CHEK1(2), CHEK2(5), TP53(67), YWHAH(1) 3188811 100 77 80 11 32 24 4 13 25 2 0.00047 3.44e-15 4.24e-13 6 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(2), CDKN2A(4), MDM2(3), PIK3CA(33), PIK3R1(7), POLR1A(8), POLR1B(2), POLR1C(2), POLR1D(1), RB1(8), TBX2(4), TP53(67), TWIST1(1) 4003294 142 87 108 24 36 48 6 21 30 1 0.000054 2.83e-14 2.91e-12 7 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(2), HSPA1A(1), IFNG(2), IFNGR1(2), IFNGR2(1), IKBKB(3), JAK2(8), LIN7A(6), NFKB1(5), RB1(8), RELA(2), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TP53(67), USH1C(1), WT1(1) 3602378 115 75 94 18 30 27 3 24 30 1 0.00043 8.90e-13 7.83e-11 8 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(10), AKT1(2), ATM(17), CDKN1A(1), CPB2(4), CSNK1D(2), FHL2(2), HIC1(1), HIF1A(2), HSPA1A(1), IGFBP3(4), MAPK8(4), MDM2(3), NFKBIB(4), NQO1(3), TP53(67) 4118242 127 84 107 21 40 33 4 19 29 2 0.00020 1.04e-12 8.00e-11 9 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(2), ATM(17), BRCA1(9), CDKN1A(1), CHEK1(2), CHEK2(5), JUN(2), MAPK8(4), MDM2(3), MRE11A(2), NFKB1(5), RAD50(6), RAD51(1), RBBP8(4), RELA(2), TP53(67), TP73(5) 5915081 137 83 117 21 36 36 5 26 32 2 0.00040 6.69e-11 4.58e-09 10 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(2), APAF1(2), ATM(17), BAD(1), BCL2(1), BID(1), CASP3(1), CASP6(1), CASP7(2), CASP9(1), CYCS(1), EIF2S1(1), PTK2(7), PXN(2), STAT1(6), TLN1(13), TP53(67) 5433042 126 78 106 18 43 32 7 16 26 2 0.000039 1.03e-10 6.37e-09 11 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(13), DAXX(3), PAX3(4), PML(4), RARA(2), RB1(8), SIRT1(3), SP100(7), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TP53(67) 3735247 117 76 97 22 38 26 4 20 28 1 0.0018 3.23e-08 1.78e-06 12 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(2), ATM(17), BCL2(1), CCND1(1), CCNE1(3), CDK2(2), CDKN1A(1), MDM2(3), PCNA(2), RB1(8), TIMP3(2), TP53(67) 3601890 109 76 88 18 31 30 4 15 27 2 0.0017 3.47e-08 1.78e-06 13 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(17), ATR(5), BRCA1(9), BRCA2(17), CHEK1(2), CHEK2(5), FANCA(6), FANCC(2), FANCD2(8), FANCE(1), FANCF(1), FANCG(3), HUS1(1), MRE11A(2), RAD1(1), RAD50(6), RAD51(1), RAD9A(1), TP53(67) 8779376 155 84 135 25 40 50 5 27 31 2 0.00022 0.0027 0.13 14 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(2), CAT(4), GH1(3), GHR(5), IGF1(2), IGF1R(11), PIK3CA(33), PIK3R1(7), SHC1(3), SOD2(1) 2629408 71 41 57 12 12 37 5 10 7 0 0.0018 0.014 0.61 15 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(5) 143247 5 5 5 1 1 0 1 1 2 0 0.55 0.019 0.77 16 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(3), CD3G(2) 225536 5 5 4 1 0 2 1 0 2 0 0.68 0.10 1.00 17 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(3), ERBB4(18), NRG2(5), NRG3(9), PSEN1(1) 1780945 36 27 35 6 8 13 4 7 4 0 0.030 0.19 1.00 18 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(2), DCN(2), FMOD(9), KERA(1), LUM(3) 721456 17 15 17 4 8 3 0 5 1 0 0.29 0.26 1.00 19 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(5), GABRA2(5), GABRA3(5), GABRA4(4), GABRA5(5), GABRA6(5), GPX1(1), PRKCE(6) 1565795 36 24 36 9 13 7 5 10 1 0 0.13 0.28 1.00 20 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(2), BAK1(2), BCL2(1), BID(1), BIRC2(2), BIRC3(4), CASP2(3), CASP3(1), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), FAS(3), JUN(2), MAP2K4(5), MAP3K1(8), MAP3K14(3), MAPK10(3), MDM2(3), NFKB1(5), PARP1(4), PRF1(1), RELA(2), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TNFSF10(2), TP53(67), TRAF1(2), TRAF2(2) 7391990 145 85 126 30 44 35 4 30 31 1 0.0013 0.28 1.00 21 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(5), CPS1(15), GLS(4), GLUD1(4), GOT1(2) 1545002 32 25 32 7 9 9 2 10 2 0 0.14 0.38 1.00 22 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCL5(1), CCR3(4), HLA-DRA(3), HLA-DRB1(1), IL3(1) 602660 11 10 11 3 4 4 0 2 1 0 0.35 0.38 1.00 23 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(4), AKT1(2), ANXA1(3), CALM1(1), CALM2(2), CALM3(1), GNAS(14), GNB1(1), GNGT1(3), NFKB1(5), NOS3(3), NPPA(1), NR3C1(5), PIK3CA(33), PIK3R1(7), RELA(2) 3543596 87 47 72 15 21 37 3 16 10 0 0.0032 0.41 1.00 24 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(2), IL12B(2), IL2(1) 592301 7 7 7 1 0 3 1 3 0 0 0.33 0.42 1.00 25 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3), SUCLA2(3) 416247 6 6 6 0 3 0 0 1 2 0 0.19 0.51 1.00 26 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(2), NR3C1(5), PPARG(1), RXRA(3), TNF(2) 1144281 14 12 14 3 3 4 1 5 1 0 0.26 0.53 1.00 27 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(2), BAD(1), CASP9(1), GH1(3), GHR(5), NFKB1(5), PDPK1(1), PIK3CA(33), PIK3R1(7), PPP2CA(3), RELA(2), YWHAH(1) 2802623 64 35 50 12 11 34 5 8 6 0 0.0083 0.54 1.00 28 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(2), PIK3CA(33), PIK3R1(7), PLCB1(12), PLCG1(10), VAV1(7) 2546225 71 46 56 14 18 32 3 10 8 0 0.013 0.56 1.00 29 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3E(3), CD3G(2), IFNG(2), IL2(1), IL2RA(1), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6), TGFBR3(2), TOB1(1), TOB2(5) 2099747 38 26 37 9 6 15 3 10 4 0 0.21 0.58 1.00 30 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), MIOX(1), UGDH(4) 1679038 29 23 29 5 6 8 0 11 4 0 0.067 0.58 1.00 31 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6) 1120150 22 17 21 5 2 9 0 6 5 0 0.26 0.60 1.00 32 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(4), GAD1(3), GAD2(4), GGT1(8) 1131431 20 17 19 5 9 4 0 7 0 0 0.24 0.60 1.00 33 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(4), ELK1(2), GRB2(1), JUN(2), MAP2K1(4), MAPK3(1), MAPK8(4), NGFR(5), PIK3CA(33), PIK3R1(7), PLCG1(10), RAF1(6), SHC1(3), SOS1(4) 3777413 86 43 71 17 19 41 4 15 7 0 0.0044 0.67 1.00 34 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(3), IL8(1), SLPI(1) 339001 5 4 5 2 2 2 0 1 0 0 0.67 0.68 1.00 35 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(1), CASP3(1), CASP8(6), CFL1(1) 763348 9 8 9 2 1 2 1 3 2 0 0.53 0.69 1.00 36 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(2), HLA-A(10), ITGB1(4), KLRC1(2), KLRC2(2), KLRD1(2), MAP2K1(4), MAPK3(1), PAK1(4), PIK3CA(33), PIK3R1(7), PTK2B(8), PTPN6(3), SYK(3), VAV1(7) 3688406 92 55 77 21 14 40 7 18 13 0 0.024 0.70 1.00 37 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(2), BAD(1), CASP9(1), CDC42(1), ELK1(2), MAP2K1(4), MAPK3(1), NFKB1(5), PIK3CA(33), PIK3R1(7), RAF1(6), RALBP1(7), RALGDS(7), RELA(2), RHOA(8) 3790430 87 45 69 19 17 43 5 14 8 0 0.011 0.73 1.00 38 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(1), TGDS(2), UGDH(4), UXS1(3) 777847 11 10 11 3 4 3 1 2 1 0 0.44 0.77 1.00 39 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF3(1), FLT3(7), IGF1(2), IL11(2), IL3(1), IL6(1), KITLG(3), TGFB1(3), TGFB2(6), TGFB3(4) 1643883 30 22 30 7 7 11 0 8 4 0 0.19 0.78 1.00 40 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4) 2628366 47 29 46 9 7 15 0 16 9 0 0.047 0.78 1.00 41 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1R(5), C1S(4), C2(2), C3(16), C5(9), C6(8), C7(2), C8A(6), C8B(8), C9(3), MASP1(4) 4166093 68 37 67 14 20 15 3 20 9 1 0.040 0.81 1.00 42 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(2) 320318 3 3 3 0 2 1 0 0 0 0 0.32 0.82 1.00 43 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(1), CASP7(2), DFFA(2), DFFB(2), ENDOG(1), HMGB2(2), TOP2A(6), TOP2B(10) 1886072 26 16 23 4 4 10 1 4 7 0 0.15 0.83 1.00 44 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOB(4), ALDOC(3), TPI1(2) 769932 10 9 10 2 2 3 0 5 0 0 0.35 0.84 1.00 45 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(2), BCAR1(4), GRB2(1), ILK(2), ITGB1(4), MAPK1(2), MAPK3(1), PDPK1(1), PIK3CA(33), PIK3R1(7), PTEN(8), PTK2(7), SHC1(3), SOS1(4) 3802640 79 44 64 15 10 38 7 11 13 0 0.0058 0.85 1.00 46 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(4), GLS2(5), GLUD1(4), GLUD2(7) 895266 20 14 20 5 6 6 0 7 1 0 0.29 0.85 1.00 47 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(4), GRB2(1), JAK2(8), JUN(2), MAP2K1(4), MAPK3(1), PIK3CA(33), PIK3R1(7), PLCG1(10), RAF1(6), RASA1(10), SHC1(3), SOS1(4), STAT1(6), STAT3(7), STAT5A(1), STAT5B(4), THPO(2) 5938169 113 48 97 21 24 50 6 17 15 1 0.00091 0.85 1.00 48 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(3), HLCS(1), SPCS3(1) 613372 5 5 5 0 3 0 0 2 0 0 0.15 0.86 1.00 49 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(4), GGPS1(2), IDI2(1), SQLE(4) 859784 11 9 10 2 4 2 0 2 3 0 0.38 0.87 1.00 50 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(2), CREB1(4), GRB2(1), MAPK1(2), MAPK3(1), MAPK7(8), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), NTRK1(4), PIK3CA(33), PIK3R1(7), PLCG1(10), RPS6KA1(6), SHC1(3) 3738987 93 45 78 18 27 43 4 11 8 0 0.0012 0.87 1.00 51 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(2), EIF2B5(4), EIF2S1(1), EIF2S2(2), EIF2S3(1), EIF4E(1), EIF4EBP1(1), GSK3B(2), IGF1(2), IGF1R(11), INPPL1(13), PDPK1(1), PIK3CA(33), PIK3R1(7), PPP2CA(3), PTEN(8), RPS6(1), RPS6KB1(3) 3901424 96 49 81 19 24 40 5 14 13 0 0.0046 0.88 1.00 52 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(2), F13B(8), HSD17B1(3), HSD17B2(1), HSD17B3(2), HSD17B4(2), HSD17B7(1), HSD3B1(1), HSD3B2(1) 1609144 21 19 21 5 4 8 1 4 4 0 0.14 0.89 1.00 53 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(1), CD36(2), FYN(5), JUN(2), MAPK14(1), THBS1(9) 1459365 20 15 20 4 6 7 0 5 2 0 0.13 0.90 1.00 54 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(20), CDH1(14), CREBBP(13), EP300(15), MAP2K1(4), MAP3K7(7), MAPK3(1), SKIL(3), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6) 5081852 98 51 97 24 17 33 5 21 21 1 0.081 0.90 1.00 55 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(3), PDXK(4), PDXP(1), PNPO(1), PSAT1(2) 954275 11 10 11 4 2 3 0 3 2 1 0.59 0.90 1.00 56 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(3), PARK2(9), SNCAIP(7), UBE2F(3), UBE2G2(2), UBE2L3(1), UBE2L6(1) 1271878 26 20 26 6 9 9 0 5 3 0 0.11 0.91 1.00 57 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(6), AOC2(4), AOC3(3), CES1(7), ESD(1) 1196455 21 16 21 6 4 7 1 8 0 1 0.38 0.93 1.00 58 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(3), CCL2(1), IL6(1), LDLR(4), LPL(2) 1053715 11 11 11 4 3 2 0 3 3 0 0.50 0.93 1.00 59 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(4), CD4(3), HLA-DRA(3), HLA-DRB1(1), IL1B(1), IL5RA(1), IL6(1) 1061395 15 13 15 5 3 5 0 5 2 0 0.52 0.93 1.00 60 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(2), FOSB(2), GRIA2(13) 739892 17 13 17 6 5 9 0 2 1 0 0.42 0.94 1.00 61 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1), LIPT1(3) 303839 4 4 4 2 0 2 0 1 1 0 0.75 0.94 1.00 62 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(2), GRB2(1), NTRK1(4), PIK3CA(33), PIK3R1(7), PLCG1(10), SHC1(3), SOS1(4) 3079735 64 38 49 13 13 34 3 8 6 0 0.015 0.94 1.00 63 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(9), FH(2), IDH1(1), IDH2(1), MDH1(3), MDH2(1), SDHB(4), SUCLA2(3) 1762795 24 18 23 4 10 5 2 5 2 0 0.066 0.94 1.00 64 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(2), GSTZ1(3), HGD(2) 443440 7 6 7 4 4 0 0 3 0 0 0.84 0.94 1.00 65 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(1), ACADS(1), ACAT1(3), HADHA(2) 1072173 9 7 8 2 2 3 0 0 4 0 0.28 0.95 1.00 66 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(5), GABRA1(5), GABRA2(5), GABRA3(5), GABRA4(4), GABRA5(5), GABRA6(5), GPHN(7), NSF(2), UBQLN1(4) 2375572 47 27 47 12 11 10 7 13 6 0 0.17 0.95 1.00 67 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(2), COQ3(2), COQ6(3), COQ7(1), NDUFA13(1) 796152 9 8 9 3 4 4 0 1 0 0 0.60 0.95 1.00 68 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(4), PAPSS2(2), SULT1A2(4), SULT1E1(3), SULT2A1(1) 1211968 16 12 16 4 7 8 0 0 1 0 0.31 0.95 1.00 69 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1R(5), C1S(4), C2(2), C3(16), C5(9), C6(8), C7(2), C8A(6), C9(3), MASP1(4), MASP2(2), MBL2(1) 4268350 63 34 63 14 18 16 3 17 8 1 0.057 0.95 1.00 70 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(4), SQLE(4) 645123 8 6 8 2 3 2 0 2 1 0 0.46 0.96 1.00 71 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(3), MTMR1(3), MTMR2(3), MTMR6(4), NFS1(2), PHPT1(3), THTPA(1), TPK1(2) 1276237 21 13 21 4 7 10 1 2 1 0 0.14 0.96 1.00 72 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(6), CYP2C9(1) 401261 7 6 7 3 2 1 0 4 0 0 0.80 0.96 1.00 73 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD34(2), CD3E(3), CD3G(2), CD4(3), CD58(1), CD8A(2), CSF3(1), IL3(1), IL6(1), IL8(1), KITLG(3) 1228410 22 18 21 8 3 8 1 6 4 0 0.63 0.96 1.00 74 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(4), CTH(2), GOT1(2), GOT2(3), LDHB(2), LDHC(1), MPST(1) 1332052 15 12 15 3 5 6 1 1 2 0 0.16 0.96 1.00 75 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(16), C5(9), C6(8), C7(2), C8A(6), C9(3) 2519797 44 28 44 11 14 11 2 12 5 0 0.14 0.97 1.00 76 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(2), CAMP(1), DAG1(7), GNAQ(1), ITPKA(1), ITPKB(6) 1188008 18 16 18 6 6 5 0 4 2 1 0.50 0.97 1.00 77 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(2), BAD(1), BAK1(2), BCL2(1), BCL2L11(1), BID(1), BIRC2(2), BIRC3(4), BIRC5(1), CASP1(2), CASP10(3), CASP2(3), CASP3(1), CASP4(2), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), DFFA(2), DFFB(2), FAS(3), HELLS(3), IKBKB(3), IRF1(1), IRF2(10), IRF3(3), IRF4(2), IRF5(2), IRF6(2), IRF7(1), JUN(2), LTA(2), MAP2K4(5), MAP3K1(8), MAPK10(3), MDM2(3), NFKB1(5), NFKBIB(4), PLEKHG5(5), PRF1(1), RELA(2), TNF(2), TNFRSF10B(2), TNFRSF1A(3), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(2), TNFSF10(2), TP53(67), TP73(5), TRAF1(2), TRAF2(2), TRAF3(2) 11314933 204 89 185 43 64 53 6 41 38 2 0.00026 0.97 1.00 78 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(2) 356672 4 3 4 2 2 1 1 0 0 0 0.73 0.97 1.00 79 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1R(5), C1S(4), C2(2), C3(16), C5(9), C6(8), C7(2), C8A(6), C9(3) 3511720 56 32 56 13 16 13 3 16 7 1 0.11 0.97 1.00 80 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(1), TGDS(2), UGDH(4), UGP2(1), UXS1(3) 986258 12 11 12 4 5 3 1 2 1 0 0.51 0.98 1.00 81 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(2), IFNGR2(1), JAK1(4), JAK2(8), STAT1(6) 1630706 23 15 23 7 5 8 1 5 3 1 0.42 0.98 1.00 82 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(2), BIRC3(4), CASP8(6), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF2(2) 1640439 20 17 20 6 6 4 1 7 2 0 0.39 0.98 1.00 83 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(6), BMPR1A(1), BMPR1B(3), BMPR2(10) 1235622 20 16 19 6 7 6 0 3 2 2 0.53 0.98 1.00 84 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(4), ALPL(3), ALPP(5), ALPPL2(4), FPGS(1), GGH(1), SPR(2) 1274303 20 15 19 7 11 3 0 3 3 0 0.36 0.98 1.00 85 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(2), CREB1(4), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K6(2), MAP3K1(8), MAPK1(2), MAPK14(1), MAPK3(1), NFKB1(5), PIK3CA(33), PIK3R1(7), RB1(8), RELA(2), SP1(3) 3851045 84 39 69 16 14 42 4 13 11 0 0.0046 0.98 1.00 86 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(2), CHPT1(1), LCMT1(1), LCMT2(7), METTL6(1), PCYT1A(7), PCYT1B(3), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), WBSCR22(2) 2787562 38 24 38 7 13 12 1 7 5 0 0.031 0.98 1.00 87 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(11), GNAS(14), GNB1(1), GNGT1(3), PRKACA(1), PRKAR1A(2) 1300583 32 18 31 9 16 8 0 4 4 0 0.33 0.98 1.00 88 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(2), BAK1(2), BCL2(1), BID(1), BIRC2(2), BIRC3(4), CASP3(1), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), DFFA(2), DFFB(2), DIABLO(1), ENDOG(1) 2685524 30 20 30 4 7 11 1 7 4 0 0.048 0.98 1.00 89 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4) 1574973 32 23 32 10 7 7 0 13 5 0 0.42 0.99 1.00 90 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4) 1574973 32 23 32 10 7 7 0 13 5 0 0.42 0.99 1.00 91 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(4), ELK1(2), GRB2(1), INSR(10), IRS1(7), JUN(2), MAP2K1(4), MAPK3(1), MAPK8(4), PIK3CA(33), PIK3R1(7), PTPN11(4), RAF1(6), RASA1(10), SHC1(3), SLC2A4(1), SOS1(4), SRF(1) 5042175 104 50 89 23 23 45 5 16 14 1 0.0035 0.99 1.00 92 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(1), HS3ST1(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), XYLT1(7), XYLT2(4) 1263913 25 18 25 7 11 9 1 1 3 0 0.23 0.99 1.00 93 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(1), HS3ST1(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), XYLT1(7), XYLT2(4) 1263913 25 18 25 7 11 9 1 1 3 0 0.23 0.99 1.00 94 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), CDC25A(2), CDC25B(4), CDC25C(3), CSK(3), GRB2(1), PTPRA(5) 1823577 19 14 19 3 7 5 0 1 6 0 0.070 0.99 1.00 95 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(1), GGT1(8), SHMT1(1), SHMT2(4) 818435 14 14 13 6 4 1 1 5 3 0 0.62 0.99 1.00 96 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 RB1(8), SP1(3), SP3(3) 1320400 14 12 13 4 1 8 0 2 3 0 0.39 0.99 1.00 97 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(2), CDC25B(4), CDKN1A(1), CHEK1(2), NEK1(4), WEE1(1) 1397462 14 12 14 3 2 5 0 3 4 0 0.46 0.99 1.00 98 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(4), ELK1(2), GRB2(1), IGF1(2), IGF1R(11), IRS1(7), JUN(2), MAP2K1(4), MAPK3(1), MAPK8(4), PIK3CA(33), PIK3R1(7), PTPN11(4), RAF1(6), RASA1(10), SHC1(3), SOS1(4), SRF(1) 4907148 106 48 91 23 22 47 5 19 12 1 0.0040 0.99 1.00 99 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(3), ACAT2(3), ACYP2(1), EHHADH(2), GCDH(3), HADHA(2), SDHB(4), SDS(1) 1546604 19 12 18 4 4 10 2 0 3 0 0.084 0.99 1.00 100 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD3E(3), CD3G(2), CD4(3) 638386 9 8 8 7 0 4 1 2 2 0 0.98 0.99 1.00 101 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(1), FUT1(2), FUT9(3), GCNT2(2), ST8SIA1(4) 1209262 12 10 12 4 3 3 0 6 0 0 0.56 0.99 1.00 102 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(1), ACADS(1), ACSL1(2), ACSL3(6), ACSL4(3), CPT1A(4), CPT2(4), EHHADH(2), HADHA(2), SCP2(3), SLC25A20(2) 3333189 32 19 31 6 6 7 3 7 9 0 0.083 0.99 1.00 103 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(4), F13A1(9), F2(4), F2R(2), FGA(5), FGB(3), FGG(2), PLAT(2), PLAU(2), PLG(10), SERPINB2(3), SERPINE1(2) 2657223 48 30 48 12 14 13 2 11 8 0 0.085 0.99 1.00 104 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(2), COASY(1), DPYD(13), DPYS(2), ENPP1(1), ENPP3(3), PANK1(2), PANK2(2), PANK4(3), UPB1(2) 2757218 31 24 31 7 8 9 1 8 5 0 0.099 0.99 1.00 105 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(13), EP300(15), ESR1(5), MAPK1(2), MAPK3(1), PELP1(6) 2887230 42 26 41 9 11 12 1 5 13 0 0.099 0.99 1.00 106 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), GPR109B(2), GPR161(2), GPR39(6), GPR45(4), GPR68(4), GPR75(5), GPR81(2) 1956733 27 18 27 8 13 5 2 6 1 0 0.18 0.99 1.00 107 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(1), EPHX2(4), HSD3B7(3), RDH11(1), RDH12(1) 948226 10 9 10 4 2 4 0 4 0 0 0.61 1.00 1.00 108 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(4), GBA3(1), GGT1(8), SHMT1(1), SHMT2(4) 1094074 19 17 18 7 7 3 1 5 3 0 0.45 1.00 1.00 109 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CCNH(2), CDC25A(2), CDC25B(4), CDC25C(3), MNAT1(2), XPO1(3) 1711745 17 11 17 3 6 3 1 3 4 0 0.15 1.00 1.00 110 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(2), BAD(1), GRB2(1), IGF1R(11), IRS1(7), MAP2K1(4), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3R1(7), RAF1(6), SHC1(3), SOS1(4), YWHAH(1) 3756942 83 43 69 20 15 44 4 12 8 0 0.023 1.00 1.00 111 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), GOT2(3), TAT(1) 519281 6 6 6 3 2 2 0 1 1 0 0.77 1.00 1.00 112 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(17), ATR(5), BRCA1(9), CCNB1(1), CDC25A(2), CDC25B(4), CDC25C(3), CDC34(1), CDKN1A(1), CDKN2D(1), CHEK1(2), CHEK2(5), EP300(15), MDM2(3), MYT1(12), PRKDC(22), RPS6KA1(6), TP53(67), WEE1(1), YWHAH(1), YWHAQ(2) 8422450 180 87 160 37 56 51 6 26 39 2 0.0015 1.00 1.00 113 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(2), BCAT2(1), COASY(1), DPYD(13), DPYS(2), ENPP1(1), ENPP3(3), ILVBL(3), PANK1(2), PANK2(2), PANK4(3), PPCDC(1), UPB1(2), VNN1(1) 3426026 37 24 37 7 13 10 1 8 5 0 0.029 1.00 1.00 114 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), IL1B(1), MST1(2), MST1R(8), TNF(2) 1290930 14 13 14 4 6 4 0 3 1 0 0.33 1.00 1.00 115 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(4), JUN(2), KEAP1(6), MAPK1(2), MAPK14(1), MAPK8(4), NFE2L2(1) 1735891 20 15 20 6 6 9 0 4 1 0 0.29 1.00 1.00 116 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), CYCS(1), GPD2(3), NDUFA1(1), SDHA(5), SDHB(4), SDHC(1), UQCRC1(2) 1310265 18 14 18 5 6 5 2 3 2 0 0.29 1.00 1.00 117 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(2), IFNGR1(2), JAK1(4), JAK2(8), PTPRU(13), REG1A(4), STAT1(6) 2271344 41 23 41 10 14 10 1 11 4 1 0.17 1.00 1.00 118 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(3), ACAT2(3), HMGCL(1), OXCT1(4) 669444 11 9 11 5 3 6 0 1 1 0 0.74 1.00 1.00 119 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3E(3), CD3G(2), CD80(1), CD86(2), CTLA4(3), GRB2(1), HLA-DRA(3), HLA-DRB1(1), ICOS(1), IL2(1), ITK(4), LCK(1), PIK3CA(33), PIK3R1(7), PTPN11(4) 2540642 67 43 52 17 11 33 5 11 7 0 0.090 1.00 1.00 120 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(4), ALOX15(2), ALOX15B(1), ALOX5(6), ALOX5AP(2), DPEP1(1), GGT1(8), LTA4H(4), PLA2G6(3), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(2) 2959416 45 30 44 11 17 11 3 11 3 0 0.094 1.00 1.00 121 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(3), CBS(3), CTH(2), MUT(3) 962808 11 10 11 9 3 3 1 1 3 0 0.98 1.00 1.00 122 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL2(2), IFNAR1(5), IFNAR2(4), IFNB1(2), MAPK8(4), NFKB1(5), RELA(2), TNFRSF11A(4), TNFSF11(1), TRAF6(4) 2201392 33 19 33 9 8 10 1 9 5 0 0.27 1.00 1.00 123 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(3), ST3GAL1(3), ST3GAL2(4), ST3GAL4(3), ST3GAL5(1), ST6GALNAC2(1), ST6GALNAC4(2), ST8SIA1(4) 1117798 21 20 21 8 10 4 0 7 0 0 0.49 1.00 1.00 124 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(2), GOSR1(2), GOSR2(2), SNAP25(1), SNAP29(3), STX10(3), STX11(2), STX16(3), STX17(1), STX18(2), STX19(3), STX2(1), STX3(1), STX4(1), STX5(2), STX6(3), STX7(1), STX8(1), TSNARE1(7), USE1(2), VAMP4(1), VAMP5(1), VAMP7(2), VTI1B(1), YKT6(1) 3290008 49 28 49 10 19 16 2 10 2 0 0.045 1.00 1.00 125 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(15), CPT1A(4), LEPR(8), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2) 2870839 37 19 37 9 15 8 2 5 7 0 0.15 1.00 1.00 126 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(2), ACOX3(5), ELOVL2(1), ELOVL5(2), FADS1(2), FADS2(4), FASN(11), HADHA(2), HSD17B12(2), SCD(4) 2800812 36 19 34 9 13 8 1 8 6 0 0.16 1.00 1.00 127 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(6), LCT(11), PGM1(3), PYGL(5), PYGM(7), TPI1(2), TREH(4) 2645520 38 23 38 10 19 10 1 4 4 0 0.14 1.00 1.00 128 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(4), AASS(2), KARS(3) 939489 9 6 9 4 2 5 1 1 0 0 0.70 1.00 1.00 129 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(2), CD3E(3), CD3G(2), HLA-A(10), ICAM1(2), ITGAL(7), ITGB2(6), PRF1(1) 1722052 33 23 32 11 9 7 4 6 7 0 0.50 1.00 1.00 130 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(3), GOT1(2), GOT2(3), TAT(1), TYR(5) 931324 14 14 14 6 3 5 0 4 2 0 0.73 1.00 1.00 131 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(3), GNAS(14), GNB1(1), GNGT1(3), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6) 1891791 36 25 35 10 14 9 1 8 4 0 0.30 1.00 1.00 132 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(3), PSMA6(3), PSMA7(3), PSMB2(1), PSMB3(1), PSMB4(1), PSMC3(6), RPN1(1), RPN2(3), UBE2A(2), UBE3A(5) 2570573 32 18 32 8 7 12 4 5 4 0 0.16 1.00 1.00 133 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IKBKB(3), IL1R1(3), IRAK1(5), MAP3K1(8), MAP3K14(3), MAP3K7(7), MYD88(2), NFKB1(5), RELA(2), TLR4(13), TNF(2), TNFAIP3(5), TNFRSF1A(3), TNFRSF1B(1), TRAF6(4) 4797754 66 39 64 17 19 15 7 18 7 0 0.11 1.00 1.00 134 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(2), CDC42(1), DLD(2), DUSP10(3), DUSP4(1), DUSP8(1), GAB1(1), GCK(3), IL1R1(3), JUN(2), MAP2K4(5), MAP2K5(1), MAP2K7(13), MAP3K1(8), MAP3K10(6), MAP3K11(3), MAP3K12(4), MAP3K13(5), MAP3K2(2), MAP3K3(2), MAP3K4(10), MAP3K5(3), MAP3K7(7), MAP3K9(5), MAPK10(3), MAPK7(8), MAPK8(4), MAPK9(3), MYEF2(4), NFATC3(3), NR2C2(3), PAPPA(14), SHC1(3), TP53(67), TRAF6(4), ZAK(3) 9952654 212 85 193 47 65 59 9 37 41 1 0.00057 1.00 1.00 135 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 EHHADH(2), HADHA(2), SDS(1) 961259 5 3 4 4 0 3 0 0 2 0 0.88 1.00 1.00 136 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(2), BCL2(1), BCR(7), GRB2(1), JAK2(8), JUN(2), MAP2K1(4), MAP2K4(5), MAP3K1(8), MAPK3(1), MAPK8(4), PIK3CA(33), PIK3R1(7), RAF1(6), SOS1(4), STAT1(6), STAT5A(1), STAT5B(4) 5559207 104 46 90 26 22 48 4 15 15 0 0.016 1.00 1.00 137 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(3), LDLR(4), NR0B2(2), NR1H3(2), NR1H4(3), RXRA(3) 1078636 17 14 17 7 7 3 0 5 2 0 0.54 1.00 1.00 138 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP2(3), ACP5(2), ACP6(3), ACPP(3), ACPT(1), ENPP1(1), ENPP3(3), FLAD1(2), LHPP(3), MTMR1(3), MTMR2(3), MTMR6(4), PHPT1(3), RFK(1), TYR(5) 2957473 40 25 40 10 10 17 2 8 3 0 0.12 1.00 1.00 139 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), ARG1(2), GLS(4), GLUD1(4) 1091327 12 9 12 5 4 4 0 3 1 0 0.59 1.00 1.00 140 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(17), CR2(4), FCGR2B(1), HLA-DRA(3), HLA-DRB1(1), ICAM1(2), ITGAL(7), ITGB2(6), PTPRC(16) 3026176 58 35 56 17 17 17 0 17 5 2 0.19 1.00 1.00 141 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(6), ADC(1), AGMAT(2), ALDH18A1(4), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), AMD1(2), AOC2(4), AOC3(3), ARG1(2), ASL(5), ASS1(6), CPS1(15), GATM(2), MAOA(1), MAOB(3), NAGS(1), ODC1(3), OTC(2), SAT1(1), SMS(2), SRM(1) 5832810 90 42 90 22 25 26 5 27 6 1 0.033 1.00 1.00 142 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(1), NDUFA8(1), NDUFB2(1), NDUFB7(1), NDUFS1(5), NDUFS2(2), NDUFV1(1) 1365674 13 12 13 4 1 5 2 3 2 0 0.54 1.00 1.00 143 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(4), GRB2(1), HBXIP(1), PTK2B(8), SHC1(3), SOS1(4) 1748610 21 14 21 7 5 8 0 3 5 0 0.49 1.00 1.00 144 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(5), PLCB1(12), RELA(2) 1636017 20 15 20 7 6 5 0 5 4 0 0.64 1.00 1.00 145 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO2(1), ENO3(3), FARS2(7), GOT1(2), GOT2(3), PAH(5), TAT(1), YARS(1) 1645117 26 18 26 9 8 10 0 5 3 0 0.45 1.00 1.00 146 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(2), DHRS3(1), DHRS7(1), DHRSX(2), LCMT1(1), LCMT2(7), METTL6(1), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), WBSCR22(2) 2969307 31 21 31 8 8 11 1 6 5 0 0.16 1.00 1.00 147 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(4), CYP11A1(2), CYP11B2(2), CYP17A1(2), HSD11B1(1), HSD11B2(2), HSD3B1(1), HSD3B2(1) 1371346 15 11 15 5 5 3 1 5 1 0 0.42 1.00 1.00 148 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(2), ACAD9(2), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), DHRS3(1), DHRS7(1), DHRSX(2), ESCO2(2), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), SH3GLB1(1) 4959740 64 35 63 16 14 24 4 14 8 0 0.066 1.00 1.00 149 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(13), EP300(15), LPL(2), NCOA1(11), NCOA2(12), PPARG(1), RXRA(3) 3665194 57 30 57 14 10 25 3 8 11 0 0.060 1.00 1.00 150 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), EHHADH(2), HADHA(2), SDS(1) 2402157 37 24 36 13 7 10 0 13 7 0 0.47 1.00 1.00 151 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(2), BIRC2(2), BIRC3(4), CASP3(1), CASP8(6), JUN(2), MAP2K4(5), MAP3K3(2), MAP3K7(7), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), NR2C2(3), RALBP1(7), TNF(2), TNFAIP3(5), TNFRSF1A(3), TNFRSF1B(1), TRAF2(2) 5364016 72 31 72 15 24 18 4 16 10 0 0.019 1.00 1.00 152 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(2), ATM(17), ATR(5), CCNA1(5), CCND1(1), CCNE1(3), CDC25A(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(4), GSK3B(2), HDAC1(2), RB1(8), SKP2(4), TFDP1(2), TGFB1(3), TGFB2(6), TGFB3(4), TP53(67) 5991513 144 83 123 35 40 38 4 30 30 2 0.032 1.00 1.00 153 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(2), CALM1(1), CALM2(2), CALM3(1), ELK1(2), FCER1A(1), GRB2(1), JUN(2), LYN(4), MAP2K1(4), MAP2K4(5), MAP2K7(13), MAP3K1(8), MAPK1(2), MAPK3(1), MAPK8(4), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), PAK2(5), PIK3CA(33), PIK3R1(7), PLA2G4A(3), PLCG1(10), PPP3CA(3), PPP3CB(1), RAF1(6), SHC1(3), SOS1(4), SYK(3), VAV1(7) 8492062 169 60 154 35 45 69 5 27 23 0 0.00013 1.00 1.00 154 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACAA2(1), ACADL(2), ACADM(1), ACADS(1), ACADSB(3), ACAT1(3), ACAT2(3), ACOX1(2), ACOX3(5), ACSL1(2), ACSL3(6), ACSL4(3), ACSL5(2), ACSL6(5), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), CPT1A(4), CPT1B(4), CPT1C(4), CPT2(4), CYP4A11(1), CYP4A22(1), EHHADH(2), GCDH(3), HADH(2), HADHA(2), HADHB(2), HSD17B4(2) 9703020 118 45 116 27 23 37 4 31 23 0 0.0078 1.00 1.00 155 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(3), CSF3(1), HLA-DRA(3), HLA-DRB1(1), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL11(2), IL12B(2), IL13(2), IL2(1), IL3(1), IL6(1), IL8(1), LTA(2), PDGFA(1), TGFB1(3), TGFB2(6), TGFB3(4), TNF(2) 2644219 42 32 42 14 9 17 1 13 2 0 0.39 1.00 1.00 156 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(4), CRK(1), CXCR4(2), GNAI1(1), GNAQ(1), GNB1(1), GNGT1(3), MAP2K1(4), MAPK1(2), MAPK3(1), NFKB1(5), PIK3C2G(3), PIK3CA(33), PIK3R1(7), PLCG1(10), PTK2(7), PTK2B(8), PXN(2), RAF1(6), RELA(2) 5493351 103 49 88 27 23 40 7 18 15 0 0.041 1.00 1.00 157 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(17), CDC25A(2), CDC25B(4), CDC25C(3), CHEK1(2), MYT1(12), WEE1(1), YWHAH(1) 2743585 42 26 41 10 16 14 2 4 5 1 0.12 1.00 1.00 158 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(1), CHST12(6), CHST13(1), PAPSS1(4), PAPSS2(2), SULT1A1(2), SULT1A2(4), SULT1E1(3), SULT2A1(1) 1818696 26 16 26 8 11 10 1 2 2 0 0.28 1.00 1.00 159 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(6), CALCR(4), CALCRL(5), CD97(2), CRHR1(2), CRHR2(3), ELTD1(9), EMR1(10), EMR2(3), GLP1R(1), GLP2R(4), GPR64(6), LPHN1(6), LPHN2(11), LPHN3(11), SCTR(2), VIPR1(4), VIPR2(4) 5281281 93 43 93 24 23 28 6 30 6 0 0.041 1.00 1.00 160 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(3), CDC34(1), CDK2(2), CUL1(10), FBXW7(11), RB1(8), TFDP1(2) 1646571 37 20 34 12 10 12 1 8 6 0 0.32 1.00 1.00 161 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 FH(2), IDH2(1), MDH1(3), OGDH(8), SDHA(5), SUCLA2(3) 1855116 22 18 21 8 8 5 1 4 4 0 0.60 1.00 1.00 162 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(2), IARS(7), LARS(3), LARS2(5), PDHA1(1), PDHA2(4), PDHB(2) 1991199 24 19 24 8 2 7 1 11 3 0 0.61 1.00 1.00 163 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(3), CYP2A13(4), CYP2A6(2), CYP2A7(3), NAT1(1), NAT2(5), XDH(9) 1582599 27 21 26 9 9 13 1 4 0 0 0.29 1.00 1.00 164 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(4), ENO1(3), GPI(4), HK1(6), PFKL(7), PGK1(1), PKLR(4), TPI1(2) 1822060 31 21 31 10 12 13 1 5 0 0 0.20 1.00 1.00 165 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(3), PSMA6(3), PSMA7(3), PSMB10(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB8(2), PSMB9(1) 1729676 19 9 19 7 7 6 2 2 2 0 0.55 1.00 1.00 166 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAA2(1), ACAT1(3), ACAT2(3), EHHADH(2), HADHA(2), HADHB(2), SDS(1) 1656270 15 9 14 5 1 8 0 2 4 0 0.41 1.00 1.00 167 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(2), ARHGAP5(6), CASP1(2), CASP10(3), CASP3(1), CASP8(6), CASP9(1), CYCS(1), JUN(2), PRF1(1) 2555679 25 17 25 8 5 5 2 8 4 1 0.61 1.00 1.00 168 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(2), AKT2(2), AKT3(3), CDKN1A(1), ELK1(2), GRB2(1), MAP2K1(4), MAP2K2(1), NGFR(5), NTRK1(4), PIK3CA(33), PIK3CD(8), SHC1(3), SOS1(4) 3179312 73 40 58 21 19 36 4 11 3 0 0.080 1.00 1.00 169 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(5), ESR2(6), ITPKA(1), PDE1A(3), PDE1B(2), PLCB1(12), PLCB2(4), PRL(2), TRH(3), VIP(1) 2190469 39 27 38 12 12 12 2 8 5 0 0.33 1.00 1.00 170 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(3), CYP2E1(5), NR1I3(3), PTGS1(5), PTGS2(2) 1057946 18 14 18 8 8 6 1 2 1 0 0.67 1.00 1.00 171 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(3), GHR(5), GRB2(1), INSR(10), IRS1(7), JAK2(8), MAP2K1(4), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3R1(7), PLCG1(10), PTPN6(3), RAF1(6), RPS6KA1(6), SHC1(3), SLC2A4(1), SOCS1(1), SOS1(4), SRF(1), STAT5A(1), STAT5B(4) 6542180 121 49 106 28 32 53 5 18 13 0 0.0036 1.00 1.00 172 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(16), GNA12(1), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAR2A(1), PRKAR2B(6) 1992584 31 23 31 10 7 13 1 7 3 0 0.29 1.00 1.00 173 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(2), CYP11A1(2), CYP11B1(2), CYP11B2(2), CYP17A1(2), CYP21A2(3), HSD11B1(1), HSD11B2(2), HSD3B1(1), HSD3B2(1) 1743048 21 16 21 8 11 5 0 4 1 0 0.45 1.00 1.00 174 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(2), CYP11A1(2), CYP11B1(2), CYP11B2(2), CYP17A1(2), CYP21A2(3), HSD11B1(1), HSD11B2(2), HSD3B1(1), HSD3B2(1) 1743048 21 16 21 8 11 5 0 4 1 0 0.45 1.00 1.00 175 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(4), BAIAP2(3), CASP1(2), CASP3(1), CASP7(2), CASP8(6), GAPDH(1), INSR(10), ITCH(3), MAGI1(16), MAGI2(10), RERE(17), WWP1(8), WWP2(10) 4728947 93 42 92 26 26 21 5 19 22 0 0.16 1.00 1.00 176 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(10), PTK2B(8) 1334888 19 16 18 9 11 3 0 4 1 0 0.77 1.00 1.00 177 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(7), CHAT(1), CHKA(1), PCYT1A(7), PDHA1(1), PDHA2(4), PEMT(1), SLC18A3(6) 1368800 28 19 28 11 14 6 0 8 0 0 0.44 1.00 1.00 178 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(2), BFAR(1), BRAF(5), CAMP(1), CREB1(4), CREB3(3), CREB5(2), MAPK1(2), RAF1(6), SNX13(6), TERF2IP(3) 2246021 35 26 35 10 13 9 0 8 5 0 0.36 1.00 1.00 179 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(20), ASAH1(2), CAMP(1), CASP3(1), CERK(3), CREB1(4), CREB3(3), CREB5(2), CXCL2(1), DAG1(7), EPHB2(11), GNAQ(1), ITPKA(1), ITPKB(6), JUN(2), MAP2K4(5), MAP2K7(13), MAPK1(2), MAPK10(3), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3) 5599881 106 40 102 29 33 27 1 22 21 2 0.091 1.00 1.00 180 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(3), CD8A(2), CSF3(1), IL11(2), IL2(1), IL3(1), IL6(1), IL8(1) 1209585 12 11 12 6 3 4 0 4 1 0 0.79 1.00 1.00 181 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(5), FADS2(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3) 2012502 32 22 32 10 14 5 1 10 2 0 0.40 1.00 1.00 182 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HADH(2), HADHA(2), HADHB(2), HSD17B4(2), MECR(3), PPT2(2) 1679667 14 8 13 4 1 5 1 3 4 0 0.33 1.00 1.00 183 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAA2(1), ACAD8(2), ACAD9(2), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), AKR1B10(1), AKR1C4(3), AKR1D1(2), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), BAAT(1), CEL(6), CYP27A1(1), CYP7A1(3), HADHB(2), HSD3B7(3), LIPA(2), RDH11(1), RDH12(1), SLC27A5(6), SOAT1(5), SOAT2(2), SRD5A1(2), SRD5A2(3) 6270702 97 44 96 26 21 33 2 28 13 0 0.065 1.00 1.00 184 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP2(3), ACP5(2), ACPP(3), ACPT(1), ENPP1(1), ENPP3(3), FLAD1(2), RFK(1), TYR(5) 1897954 21 16 21 7 4 8 1 5 3 0 0.48 1.00 1.00 185 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(4), ABP1(6), ACADL(2), ACADM(1), ACADSB(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), AOC2(4), AOC3(3), CNDP1(1), DPYD(13), DPYS(2), EHHADH(2), GAD1(3), GAD2(4), HADHA(2), MLYCD(3), SDS(1), SMS(2), UPB1(2) 5752530 90 42 88 27 23 31 2 23 10 1 0.11 1.00 1.00 186 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(8), EIF2AK4(5), EIF2B5(4), EIF2S1(1), EIF2S2(2), EIF2S3(1), EIF5(3), GSK3B(2), PPP1CA(2) 2288962 28 21 28 9 5 12 1 9 1 0 0.41 1.00 1.00 187 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(11), CREM(1), FHL5(1), FSHB(2), FSHR(17), GNAS(14), XPO1(3) 1892432 49 29 46 14 17 13 2 14 3 0 0.44 1.00 1.00 188 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(2), CDK5R1(1), CSNK1D(2), DRD1(3), DRD2(6), GRM1(17), PLCB1(12), PPP1CA(2), PPP2CA(3), PPP3CA(3), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6) 3166545 66 36 66 22 21 24 0 15 6 0 0.26 1.00 1.00 189 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(3), CDK2(2), CUL1(10), NEDD8(1), RB1(8), SKP2(4), TFDP1(2) 1709248 30 19 29 11 5 11 1 8 5 0 0.51 1.00 1.00 190 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(4), FUT1(2), FUT9(3), HEXA(1), HEXB(3), NAGA(3), ST3GAL1(3), ST3GAL2(4), ST3GAL4(3), ST8SIA1(4) 2003353 30 24 30 10 12 5 0 12 1 0 0.48 1.00 1.00 191 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM2(2), CALM3(1), CDKN1A(1), GNAQ(1), MARCKS(2), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), PLCG1(10), PPP3CA(3), PPP3CB(1), SP1(3), SP3(3) 4113345 59 32 57 17 20 24 0 8 7 0 0.10 1.00 1.00 192 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(3), GALNT10(3), GALNT2(3), GALNT3(1), GALNT4(1), GALNT6(2), GALNT8(5), GALNT9(3), GCNT1(1), ST3GAL1(3), ST3GAL2(4), ST3GAL4(3), WBSCR17(14) 2853308 46 30 44 12 20 10 4 9 3 0 0.16 1.00 1.00 193 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3E(3), CD3G(2), ETV5(5), IFNG(2), IL12B(2), IL12RB1(4), IL12RB2(5), IL18R1(2), JAK2(8), JUN(2), MAP2K6(2), MAPK14(1), MAPK8(4), STAT4(4), TYK2(6) 3674289 53 27 52 15 9 19 3 12 10 0 0.23 1.00 1.00 194 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(9), AMT(4), ATIC(5), GART(6), MTHFD1(3), MTHFD1L(2), MTHFD2(1), MTHFR(5), MTR(9), SHMT1(1), SHMT2(4), TYMS(1) 3544578 50 31 50 15 13 16 4 8 9 0 0.17 1.00 1.00 195 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(4), ABP1(6), ACADM(1), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), AOC2(4), AOC3(3), CNDP1(1), DPYD(13), DPYS(2), EHHADH(2), GAD1(3), GAD2(4), HADHA(2), MLYCD(3), SMS(2), SRM(1), UPB1(2) 5342259 77 39 75 23 21 25 2 20 8 1 0.11 1.00 1.00 196 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(3), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), CYP2C19(6), CYP2C9(1), DHRS3(1), DHRS7(1), DHRSX(2), EHHADH(2), ESCO2(2), HADHA(2), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), SH3GLB1(1), YOD1(2) 6119325 77 37 76 21 20 23 3 22 9 0 0.089 1.00 1.00 197 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(1), SRP19(1), SRP54(2), SRP72(4), SRPR(3) 1491187 12 10 12 5 4 5 0 2 1 0 0.74 1.00 1.00 198 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(5), IFNB1(2), JAK1(4), PTPRU(13), REG1A(4), STAT1(6), STAT2(4), TYK2(6) 2463540 44 26 44 13 17 11 0 11 4 1 0.30 1.00 1.00 199 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(4), ASNS(4), ASRGL1(1), CA1(1), CA12(2), CA13(2), CA14(1), CA2(1), CA3(1), CA4(2), CA5B(1), CA6(3), CA7(2), CA8(1), CA9(2), CPS1(15), CTH(2), GLS(4), GLS2(5), GLUD1(4), GLUD2(7), GLUL(2), HAL(2) 4197941 69 38 69 20 20 18 4 21 6 0 0.19 1.00 1.00 200 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(3), ACAT2(3), BDH1(1), HMGCL(1), HMGCS1(1), HMGCS2(1), OXCT1(4) 1429775 14 12 14 8 4 6 0 3 1 0 0.87 1.00 1.00 201 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ACAA2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), AKR1C4(3), AKR1D1(2), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), BAAT(1), CEL(6), CYP27A1(1), CYP7A1(3), HADHB(2), SOAT2(2), SRD5A1(2), SRD5A2(3) 4596996 81 39 80 25 17 27 0 24 13 0 0.24 1.00 1.00 202 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(4), ADORA2B(1), ADORA3(2), LTB4R(2), P2RY1(5), P2RY2(1), P2RY6(3) 1172555 18 15 18 9 7 4 0 6 1 0 0.74 1.00 1.00 203 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(4), CARS2(2), CTH(2), GOT1(2), GOT2(3), LDHAL6B(2), LDHB(2), LDHC(1), MPST(1), SDS(1), SULT1B1(2), SULT1C4(1), SULT4A1(1) 2456977 24 16 24 8 8 9 1 3 3 0 0.36 1.00 1.00 204 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(1), JUN(2), MAP2K1(4), MAPK1(2), MAPK3(1), NFKB1(5), PLCB1(12), RAF1(6), RELA(2), TNF(2) 3075622 37 24 37 12 10 10 1 11 5 0 0.44 1.00 1.00 205 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(3), GNAQ(1), GNB1(1), GNGT1(3), HTR2C(3), PLCB1(12), TUB(6) 1415903 29 20 29 10 12 7 0 5 5 0 0.48 1.00 1.00 206 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(1), AKT1(2), AKT2(2), AKT3(3), APAF1(2), ATM(17), BAD(1), BCL2(1), BID(1), BIRC2(2), BIRC3(4), CAPN1(3), CAPN2(4), CASP10(3), CASP3(1), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CSF2RB(7), CYCS(1), DFFA(2), DFFB(2), ENDOG(1), FAS(3), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(3), IL3(1), IL3RA(4), IRAK1(5), IRAK2(4), IRAK3(2), IRAK4(3), MAP3K14(3), MYD88(2), NFKB1(5), NFKB2(3), NTRK1(4), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RELA(2), TNF(2), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(2), TNFRSF10D(2), TNFRSF1A(3), TNFSF10(2), TP53(67), TRAF2(2) 16539850 301 101 264 72 89 100 11 55 44 2 0.00021 1.00 1.00 207 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(4), B3GAT2(1), B3GAT3(2), B4GALT7(1), CHPF(2), CHST11(1), CHST12(6), CHST13(1), CHST3(1), CHST7(1), CHSY1(3), DSE(6), UST(5), XYLT1(7), XYLT2(4) 2700217 45 25 45 12 20 15 2 6 2 0 0.093 1.00 1.00 208 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(6), ACY3(1), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH3B2(4), ALDH9A1(4), AOC2(4), AOC3(3), CARM1(2), CNDP1(1), DDC(3), HAL(2), HARS(4), HARS2(3), HDC(5), HNMT(1), LCMT1(1), LCMT2(7), MAOA(1), MAOB(3), METTL6(1), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), PRPS1(1), PRPS2(3), UROC1(4), WBSCR22(2) 7831637 100 45 99 27 22 29 4 34 10 1 0.067 1.00 1.00 209 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(3), CLOCK(2), CRY1(1), CRY2(2), CSNK1E(6), PER1(4) 1667690 18 12 18 7 5 5 1 5 2 0 0.70 1.00 1.00 210 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS3(1), DHRS7(1), DHRSX(2), ESCO2(2), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), SH3GLB1(1) 3281044 37 26 37 11 11 12 3 8 3 0 0.24 1.00 1.00 211 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(5), EGFR(10), ERBB3(21), NRG1(9) 2021890 45 25 42 15 13 12 1 15 4 0 0.44 1.00 1.00 212 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(16), C5(9), C6(8), C7(2), ICAM1(2), IL6(1), IL8(1), ITGA4(8), ITGAL(7), ITGB1(4), ITGB2(6), SELP(2), SELPLG(6), TNF(2), VCAM1(5) 4933886 79 39 78 24 25 19 2 25 8 0 0.15 1.00 1.00 213 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(9), AMT(4), ATIC(5), GART(6), MTHFD1(3), MTHFD1L(2), MTHFD2(1), MTHFR(5), MTR(9), SHMT1(1), SHMT2(4), TYMS(1) 3743352 50 31 50 16 13 16 4 8 9 0 0.23 1.00 1.00 214 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(5), AGT(2), AGTR1(1), AGTR2(1), COL4A1(13), COL4A2(7), COL4A3(4), COL4A4(7), COL4A5(5), COL4A6(7), REN(3) 5039420 55 32 55 19 13 23 1 15 3 0 0.27 1.00 1.00 215 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(8), APOBEC1(3), APOBEC3A(1), APOBEC3B(3), APOBEC3G(2), APOBEC4(1) 1453284 18 14 18 7 8 3 2 4 1 0 0.64 1.00 1.00 216 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACO1(9), ACSS1(7), ACSS2(3), FH(2), IDH1(1), IDH2(1), MDH1(3), MDH2(1), SUCLA2(3) 2635325 32 21 31 11 10 6 4 7 5 0 0.42 1.00 1.00 217 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), HMOX1(3), IL10(1), IL10RA(2), IL10RB(1), IL6(1), JAK1(4), STAT1(6), STAT3(7), STAT5A(1), TNF(2) 2417612 30 19 30 10 5 15 0 8 1 1 0.36 1.00 1.00 218 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), MDH1(3), ME1(3), PC(6), PDHA1(1), SLC25A1(2) 1829312 17 12 17 8 8 2 3 3 1 0 0.71 1.00 1.00 219 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(1), CREBBP(13), EP300(15), FYN(5), IL2RG(3), IL7R(3), JAK1(4), JAK3(3), LCK(1), NMI(1), PIK3CA(33), PIK3R1(7), PTK2B(8), STAT5A(1), STAT5B(4) 5532650 102 48 87 29 19 41 4 18 19 1 0.13 1.00 1.00 220 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(3), HK1(6), HK2(6), HK3(3), IMPA1(3), PGM1(3), PGM3(6), TGDS(2) 2022812 32 19 32 11 13 13 3 1 2 0 0.22 1.00 1.00 221 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(3), CYB5R3(1), GCK(3), GFPT1(3), GNE(3), GNPDA1(3), GNPDA2(1), HEXA(1), HEXB(3), HK1(6), HK2(6), HK3(3), PGM3(6), RENBP(2) 3346301 44 26 44 12 20 12 4 6 2 0 0.11 1.00 1.00 222 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(5), GUSB(3), UCHL1(2), UCHL3(3), UGDH(4), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2B15(1), UGT2B4(2) 3479638 25 16 25 9 7 11 0 3 4 0 0.46 1.00 1.00 223 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(4), ARG1(2), ASL(5), CKB(1), CKMT1A(2), CKMT1B(3), CKMT2(6), CPS1(15), GATM(2), GLUD1(4), NAGS(1), ODC1(3), OTC(2), PYCR1(2), SMS(2) 3449399 54 31 54 16 23 13 3 14 1 0 0.19 1.00 1.00 224 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRA2A(2), ADRA2C(3), ADRB1(3), ADRB2(4), ADRB3(1), CHRM1(3), CHRM2(7), CHRM3(6), CHRM4(2), CHRM5(3), DRD1(3), DRD2(6), DRD3(8), DRD4(1), DRD5(10), HRH1(3), HRH2(4), HTR1A(6), HTR1B(5), HTR1D(4), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(5), HTR2C(3), HTR4(4), HTR5A(4), HTR6(1), HTR7(4) 5062052 125 44 121 38 51 32 7 27 8 0 0.025 1.00 1.00 225 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(15), ACACB(13), FASN(11), MCAT(1), OXSM(3) 3095404 43 21 42 13 14 11 1 7 10 0 0.26 1.00 1.00 226 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(8), AP2A1(1), AP2M1(7), CALM1(1), CALM2(2), CALM3(1), DNM1(5), EPN1(4), PICALM(1), PPP3CA(3), PPP3CB(1), SYNJ1(7), SYNJ2(15) 4276223 56 28 52 16 22 9 2 15 8 0 0.23 1.00 1.00 227 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(3), GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(2), HDAC3(4), NCOA1(11), NCOA2(12), NCOA3(7), NCOR2(15), POLR2A(9), RARA(2), RXRA(3), TBP(3) 4922630 79 39 79 27 21 31 2 18 7 0 0.24 1.00 1.00 228 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(3), ACAT2(3), ACOT11(3), ACYP2(1), DHRS3(1), DHRS7(1), DHRSX(2), EHHADH(2), ESCO2(2), FN3K(2), GCDH(3), HADHA(2), ITGB1BP3(3), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), SH3GLB1(1), YOD1(2) 5147020 61 32 60 17 16 25 4 9 7 0 0.069 1.00 1.00 229 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), EIF4E(1), FBL(2), GPT(1), LDHB(2), LDHC(1), MAPK14(1), NCL(7) 1752576 18 13 18 8 6 5 0 6 1 0 0.75 1.00 1.00 230 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ARG1(2), ASL(5), ASS1(6), CKB(1), CKMT1A(2), CKMT1B(3), CKMT2(6), CPS1(15), DAO(5), EPRS(6), GATM(2), GLUD1(4), GLUD2(7), GOT1(2), GOT2(3), LAP3(1), NOS1(16), NOS3(3), OTC(2), P4HA1(1), P4HA2(6), P4HA3(1), PARS2(1), PYCR1(2), PYCR2(1), PYCRL(1), RARS(2), RARS2(2) 7087433 110 50 109 29 38 29 5 29 9 0 0.052 1.00 1.00 231 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(4), CREM(1), JUN(2), MAPK3(1), OPRK1(4), POLR2A(9), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6) 2541511 36 23 36 13 10 14 0 8 4 0 0.37 1.00 1.00 232 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(4), EPX(4), LPO(2), MPO(5), MTHFR(5), PRDX6(1), SHMT1(1), SHMT2(4), TPO(13) 2297007 40 27 40 13 13 7 3 11 6 0 0.41 1.00 1.00 233 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(2), ARFGAP1(1), ARFGAP3(4), ARFGEF2(14), CLTA(2), COPA(4), GBF1(8), GPLD1(9), KDELR1(1) 3203218 45 26 45 14 13 21 1 9 1 0 0.18 1.00 1.00 234 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(2), BIRC2(2), BIRC3(4), CASP1(2), CASP10(3), CASP2(3), CASP3(1), CASP4(2), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), DFFA(2), DFFB(2), LMNA(5), LMNB1(2), LMNB2(3), PRF1(1) 3811870 45 27 45 12 14 14 4 9 4 0 0.22 1.00 1.00 235 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(1), DHRS3(1), DHRS7(1), DHRSX(2), HSD3B7(3), PON1(1), PON2(2), RDH11(1), RDH12(1) 1780250 13 13 13 9 4 4 1 3 1 0 0.94 1.00 1.00 236 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), BCL2(1), CASP8(6), CYCS(1), MAP2K1(4), MAP2K4(5), MAP3K1(8), MAPK1(2), MAPK3(1), MAPK8(4), NFKB1(5), NSMAF(9), RAF1(6), RELA(2), SMPD1(4), TNFRSF1A(3), TRAF2(2) 4050604 64 29 64 20 20 19 2 13 10 0 0.23 1.00 1.00 237 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSR(4), GSS(1), IL8(1), NFKB1(5), NOX1(4), RELA(2), TNF(2), XDH(9) 1983346 29 18 29 10 5 13 1 7 3 0 0.43 1.00 1.00 238 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(2), AVP(3), CABIN1(8), CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), HDAC5(4), IGF1(2), IGF1R(11), INSR(10), MAP2K6(2), MAPK14(1), MAPK7(8), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), MYOD1(3), NFATC1(9), NFATC2(8), PIK3CA(33), PIK3R1(7), PPP3CA(3), PPP3CB(1), YWHAH(1) 6848276 136 53 122 36 42 57 5 21 11 0 0.0031 1.00 1.00 239 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(3), GPLD1(9), PGAP1(4), PIGA(2), PIGB(4), PIGC(2), PIGG(5), PIGK(1), PIGL(1), PIGM(4), PIGN(3), PIGO(1), PIGQ(2), PIGS(1), PIGT(3), PIGV(3), PIGX(2), PIGZ(2) 4747955 52 28 52 16 16 21 3 6 5 1 0.12 1.00 1.00 240 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2G(4), CAMK4(4), CAMKK1(4), CAMKK2(1), CREB1(4) 2277358 28 17 28 10 7 12 1 5 3 0 0.45 1.00 1.00 241 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(2), CCND1(1), CCNE1(3), CDK2(2), CDK6(4), CDKN1A(1), MAPK1(2), MAPK3(1), NFKB1(5), PAK1(4), PIK3CA(33), PIK3R1(7), RAF1(6), RB1(8), RELA(2), TFDP1(2) 4012864 83 44 68 25 13 39 4 16 11 0 0.19 1.00 1.00 242 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(2), BIRC2(2), BIRC3(4), CASP10(3), CASP3(1), CASP7(2), CASP8(6), CASP9(1), DFFA(2), DFFB(2), PRF1(1), SCAP(7), SREBF1(4), SREBF2(7) 3572783 44 30 44 13 13 14 3 9 5 0 0.33 1.00 1.00 243 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(4), ASNS(4), CA1(1), CA12(2), CA14(1), CA2(1), CA3(1), CA4(2), CA5B(1), CA6(3), CA7(2), CA8(1), CA9(2), CPS1(15), CTH(2), GLS(4), GLS2(5), GLUD1(4), GLUL(2), HAL(2) 3755719 59 33 59 19 15 17 4 17 6 0 0.34 1.00 1.00 244 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(4), JAK2(8), JAK3(3), PIAS1(3), PIAS3(1), PTPRU(13), REG1A(4), SOAT1(5) 2726935 43 25 43 13 13 11 0 12 6 1 0.44 1.00 1.00 245 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(3), CLOCK(2), CRY1(1), CRY2(2), CSNK1D(2), CSNK1E(6), NPAS2(5), NR1D1(3), PER1(4), PER2(10), PER3(7) 3357480 45 22 45 14 13 14 3 10 5 0 0.30 1.00 1.00 246 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(2), FDPS(4), HMGCR(5), LSS(5), MVD(2), MVK(4), NQO1(3), NQO2(3), SC5DL(1), SQLE(4), VKORC1(1) 2191139 34 21 34 12 13 9 1 9 2 0 0.45 1.00 1.00 247 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(2), ESR1(5), GREB1(12), HSPB1(1), HSPB2(1), MTA1(6), PDZK1(2), TUBA8(3) 2159489 32 22 32 13 10 12 1 4 5 0 0.54 1.00 1.00 248 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(2), DLG4(5), EPHB2(11), F2(4), F2RL1(3), F2RL2(1), JUN(2), MAP2K5(1), MAPK1(2), MAPK7(8), MAPK8(4), MYEF2(4), PLD1(7), PLD2(11), PLD3(5), PTK2(7), RAF1(6), RASAL1(1), TEC(3), VAV1(7) 5409910 94 40 91 28 28 31 4 19 12 0 0.16 1.00 1.00 249 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(2), ATM(17), ATR(5), BAI1(7), BID(1), CASP3(1), CASP8(6), CASP9(1), CCNB1(1), CCNB2(1), CCNB3(7), CCND1(1), CCND2(1), CCND3(2), CCNE1(3), CCNE2(1), CCNG2(1), CD82(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(4), CHEK1(2), CHEK2(5), CYCS(1), DDB2(2), EI24(1), FAS(3), GTSE1(4), IGF1(2), IGFBP3(4), LRDD(4), MDM2(3), MDM4(3), PERP(2), PPM1D(4), PTEN(8), RFWD2(5), RPRM(3), RRM2(2), RRM2B(2), SERPINB5(3), SERPINE1(2), SESN1(1), SESN2(1), SESN3(2), SIAH1(1), STEAP3(5), THBS1(9), TNFRSF10B(2), TP53(67), TP73(5), TSC2(4), ZMAT3(2) 12906690 235 96 215 62 72 68 7 43 43 2 0.0088 1.00 1.00 250 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 IFNG(2), IKBKB(3), IL2(1), JUN(2), MAP3K1(8), MAP3K5(3), MAP4K5(4), MAPK14(1), MAPK8(4), NFKB1(5), RELA(2), TNFRSF9(3), TRAF2(2) 3858434 40 21 39 12 15 7 2 10 6 0 0.37 1.00 1.00 251 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(6), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH3B2(4), ALDH9A1(4), AOC2(4), AOC3(3), CNDP1(1), DDC(3), HAL(2), HARS(4), HDC(5), HNMT(1), MAOA(1), MAOB(3), PRPS1(1), PRPS2(3) 4839432 73 38 72 24 17 20 3 26 6 1 0.33 1.00 1.00 252 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2E2(2), GTF2F1(2), GTF2F2(2), GTF2H1(1), GTF2H3(1), GTF2I(4), GTF2IRD1(9), TAF1(5), TAF10(1), TAF13(1), TAF1L(11), TAF2(5), TAF4(3), TAF4B(2), TAF5(2), TAF5L(4), TAF6(7), TAF6L(1), TAF7(4), TAF7L(3), TAF9B(2), TBPL2(3) 7152812 83 38 80 23 26 28 3 16 10 0 0.094 1.00 1.00 253 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(5), IFNAR2(4), IFNB1(2), JAK1(4), STAT1(6), STAT2(4), TYK2(6) 2143249 32 18 32 11 9 11 0 7 4 1 0.47 1.00 1.00 254 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(4), ELK1(2), EPOR(2), GRB2(1), JAK2(8), JUN(2), MAP2K1(4), MAPK3(1), MAPK8(4), PLCG1(10), PTPN6(3), RAF1(6), SHC1(3), SOS1(4), STAT5A(1), STAT5B(4) 4249380 59 28 58 18 15 23 1 13 7 0 0.27 1.00 1.00 255 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(3), PSMA6(3), PSMA7(3), PSMB2(1), PSMB3(1), PSMB4(1), PSMC2(3), PSMC3(6), PSMD1(4), PSMD11(1), PSMD12(1), PSMD2(10), PSMD6(1) 3157005 41 21 41 11 12 15 2 9 3 0 0.23 1.00 1.00 256 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(3), G6PD(2), GCLM(2), GGT1(8), GPX1(1), GPX3(1), GPX4(3), GPX6(2), GPX7(3), GSR(4), GSS(1), GSTA1(2), GSTA2(1), GSTA4(1), GSTA5(1), GSTM1(1), GSTM3(1), GSTM4(1), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(3), IDH1(1), IDH2(1), MGST1(2), MGST2(1), MGST3(1), OPLAH(5), TXNDC12(1) 4295304 58 30 57 19 20 17 2 16 3 0 0.28 1.00 1.00 257 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(4), ANKRD1(2), DUSP14(1), EIF4E(1), EIF4EBP1(1), IFNG(2), IFRD1(2), IL1R1(3), NR4A3(1), WDR1(1) 2117610 18 12 18 9 5 4 4 4 1 0 0.77 1.00 1.00 258 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(2), ABP1(6), AOC2(4), AOC3(3), CES1(7), CES7(7), DDHD1(7), ESCO2(2), LIPA(2), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), PRDX6(1), SH3GLB1(1) 5032944 72 35 71 22 20 26 4 18 3 1 0.18 1.00 1.00 259 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 COPS5(3), CREB1(4), EDN1(3), EP300(15), HIF1A(2), JUN(2), NOS3(3), P4HB(4) 3351533 36 23 36 12 11 10 2 7 6 0 0.38 1.00 1.00 260 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(7), CHAT(1), COMT(3), DBH(2), DDC(3), GAD1(3), GAD2(4), HDC(5), MAOA(1), PAH(5), PNMT(3), SLC18A3(6), TH(1), TPH1(1) 2830261 46 26 46 18 17 13 2 12 2 0 0.43 1.00 1.00 261 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(9), DLD(2), DLST(1), FH(2), IDH1(1), IDH2(1), IDH3A(1), IDH3B(3), IDH3G(2), MDH1(3), MDH2(1), PC(6), PCK1(4), SDHA(5), SDHB(4), SUCLA2(3), SUCLG1(2), SUCLG2(4) 4068735 54 29 53 18 23 11 2 13 5 0 0.29 1.00 1.00 262 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(13), DUSP1(1), EP300(15), IKBKB(3), IL1B(1), IL8(1), MAP2K3(1), MAP2K6(2), MAP3K14(3), MAP3K7(7), MAPK11(1), MAPK14(1), MYD88(2), NFKB1(5), NR3C1(5), RELA(2), TGFBR1(2), TGFBR2(6), TLR2(3), TNF(2) 5856775 76 38 76 24 16 23 4 18 15 0 0.36 1.00 1.00 263 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNA1(1), IFNB1(2), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(3), IL6(1), IRAK1(5), IRAK2(4), IRAK3(2), JUN(2), MAP2K3(1), MAP2K6(2), MAP3K1(8), MAP3K14(3), MAP3K7(7), MAPK14(1), MAPK8(4), MYD88(2), NFKB1(5), RELA(2), TGFB1(3), TGFB2(6), TGFB3(4), TNF(2), TOLLIP(1), TRAF6(4) 5857347 82 38 81 25 21 23 4 25 9 0 0.31 1.00 1.00 264 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(10), ABCB11(6), ABCB4(13), ABCC1(4), ABCC3(6), GSTP1(1) 2848513 40 25 40 15 10 15 1 8 6 0 0.50 1.00 1.00 265 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(5), AGT(2), AGTR2(1), EDN1(3), EDNRA(3), EDNRB(13), EGF(5), EGFR(10), JUN(2), NFKB1(5), PLCG1(10), RELA(2) 4079402 61 28 59 22 20 13 2 18 8 0 0.44 1.00 1.00 266 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(4), ELK1(2), GRB2(1), JAK1(4), JUN(2), MAP2K1(4), MAP2K4(5), MAP3K1(8), MAPK3(1), MAPK8(4), PDGFA(1), PDGFRA(4), PIK3CA(33), PIK3R1(7), PLCG1(10), RAF1(6), RASA1(10), SHC1(3), SOS1(4), SRF(1), STAT1(6), STAT3(7), STAT5A(1) 6918924 128 53 112 32 31 55 5 19 16 2 0.0099 1.00 1.00 267 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(1), AGTR2(1), ATP8A1(7), AVPR1A(7), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(3), C3AR1(2), CCKAR(2), CCKBR(4), CCR1(2), CCR10(2), CCR2(3), CCR3(4), CCR5(1), CCR6(1), CCR8(2), CX3CR1(4), CXCR4(2), CXCR6(1), EDNRA(3), EDNRB(13), FPR1(1), FSHR(17), GALR1(3), GALR2(1), GALR3(1), GALT(1), GHSR(4), GNRHR(3), GRPR(3), LHCGR(7), MC2R(2), MC3R(3), MC4R(4), MC5R(6), NMBR(1), NPY1R(2), NPY2R(1), NPY5R(1), NTSR1(4), OPRD1(3), OPRK1(4), OPRL1(2), OXTR(4), PPYR1(7), SSTR1(10), SSTR2(2), SSTR3(4), SSTR4(8), TAC4(1), TACR1(3), TACR2(2), TACR3(6), TRHR(6), TSHR(8) 10300069 203 67 198 61 72 71 4 41 15 0 0.0030 1.00 1.00 268 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ARPC1A(3), ARPC1B(1), ARPC4(1), CDC42(1), PAK1(4), PDGFRA(4), PIK3CA(33), PIK3R1(7), WASL(1) 2658487 57 38 43 18 11 31 4 5 6 0 0.23 1.00 1.00 269 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(8), CALM1(1), CALM2(2), CALM3(1), CAPN2(4), CAPNS1(1), CAPNS2(1), EP300(15), HDAC1(2), HDAC2(4), MEF2D(6), NFATC1(9), NFATC2(8), PPP3CA(3), PPP3CB(1) 4814967 66 27 66 20 24 21 0 12 9 0 0.13 1.00 1.00 270 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(3), CHIA(2), CHIT1(2), CMAS(3), CTBS(2), CYB5R1(1), CYB5R3(1), GFPT1(3), GFPT2(3), GNE(3), GNPDA1(3), GNPDA2(1), HEXA(1), HEXB(3), HK1(6), HK2(6), HK3(3), LHPP(3), MTMR1(3), MTMR2(3), MTMR6(4), NAGK(1), NANS(1), NPL(1), PGM3(6), PHPT1(3), RENBP(2) 5660317 73 33 73 23 28 24 5 14 2 0 0.14 1.00 1.00 271 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(2), CALM3(1), DLG4(5), GRIN1(4), GRIN2A(7), GRIN2B(13), GRIN2C(4), GRIN2D(1), NOS1(16), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6) 5038985 73 36 73 27 26 26 1 12 8 0 0.38 1.00 1.00 272 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(3), DHCR7(2), FDPS(4), HMGCR(5), HMGCS1(1), LSS(5), MVD(2), MVK(4), NSDHL(3), SC4MOL(2), SC5DL(1), SQLE(4) 2612233 36 20 36 13 13 8 2 11 2 0 0.53 1.00 1.00 273 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(4), ACACA(15), ACADL(2), ACADM(1), ACADSB(3), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH6A1(1), ALDH9A1(4), EHHADH(2), HADHA(2), LDHB(2), LDHC(1), MCEE(3), MLYCD(3), MUT(3), PCCA(7), PCCB(2), SDS(1), SUCLA2(3), SUCLG1(2), SUCLG2(4) 6540273 99 37 95 29 26 32 0 21 20 0 0.17 1.00 1.00 274 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(2), APC(20), AXIN1(7), CCND1(1), CD14(1), CTNNB1(11), DVL1(4), FZD1(8), GJA1(8), GNAI1(1), GSK3B(2), IRAK1(5), LEF1(4), LY96(1), MYD88(2), NFKB1(5), PDPK1(1), PIK3CA(33), PIK3R1(7), PPP2CA(3), RELA(2), TIRAP(2), TLR4(13), TOLLIP(1), WNT1(3) 6057735 147 69 129 40 30 50 11 34 20 2 0.037 1.00 1.00 275 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(1), CALM2(2), CALM3(1), CD3E(3), CD3G(2), ELK1(2), FYN(5), GRB2(1), JUN(2), LCK(1), MAP2K1(4), MAP2K4(5), MAP3K1(8), MAPK3(1), MAPK8(4), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NFKB1(5), PIK3CA(33), PIK3R1(7), PLCG1(10), PPP3CA(3), PPP3CB(1), PTPN7(2), RAF1(6), RASA1(10), RELA(2), SHC1(3), SOS1(4), VAV1(7), ZAP70(4) 9436958 170 59 153 41 42 66 6 28 27 1 0.0031 1.00 1.00 276 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPAT6(2), AGPS(3), CHPT1(1), ENPP2(3), ENPP6(2), PAFAH1B1(3), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLD1(7), PLD2(11), PPAP2C(5) 4600941 70 31 70 23 21 25 3 13 8 0 0.24 1.00 1.00 277 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(2), CREB1(4), CREBBP(13), EP300(15), NCOA3(7), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RARA(2), RXRA(3) 4082329 61 32 61 22 14 24 2 8 13 0 0.35 1.00 1.00 278 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(5), ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), FPGT(3), GCK(3), GMDS(2), GMPPA(4), HK1(6), HK2(6), HK3(3), PFKFB3(2), PFKFB4(1), PFKM(3), PFKP(8), PMM1(1), PMM2(1), TPI1(2) 4749720 61 27 61 20 30 17 2 9 3 0 0.15 1.00 1.00 279 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(6), ALDH1A3(6), ALDH3A1(5), ALDH3B2(4), AOC2(4), AOC3(3), DDC(3), EPX(4), GOT1(2), GOT2(3), HPD(1), LPO(2), MAOA(1), MAOB(3), MPO(5), PRDX6(1), TAT(1), TPO(13) 4342043 67 36 67 23 19 16 1 24 6 1 0.44 1.00 1.00 280 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(13), COL4A2(7), COL4A3(4), COL4A4(7), COL4A5(5), COL4A6(7), P4HB(4), SLC23A1(6), SLC23A2(7), SLC2A1(3), SLC2A3(2) 5002789 65 30 65 28 18 25 0 15 7 0 0.58 1.00 1.00 281 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(2), AKT2(2), AKT3(3), BPNT1(2), GRB2(1), ILK(2), MAPK1(2), MAPK3(1), PDK1(1), PIK3CA(33), PIK3CD(8), PTEN(8), PTK2B(8), RBL2(1), SHC1(3), SOS1(4) 4043997 81 46 66 23 23 36 3 11 8 0 0.13 1.00 1.00 282 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(4), EGF(5), EGFR(10), ELK1(2), GRB2(1), JAK1(4), JUN(2), MAP2K1(4), MAP2K4(5), MAP3K1(8), MAPK3(1), MAPK8(4), PIK3CA(33), PIK3R1(7), PLCG1(10), RAF1(6), RASA1(10), SHC1(3), SOS1(4), SRF(1), STAT1(6), STAT3(7), STAT5A(1) 7430699 138 56 122 35 32 56 5 24 19 2 0.012 1.00 1.00 283 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(2), BAD(1), CHRNG(3), MUSK(5), PIK3CA(33), PIK3R1(7), PTK2(7), PTK2B(8), RAPSN(2), TERT(3), YWHAH(1) 3227060 72 42 58 25 16 31 6 11 8 0 0.31 1.00 1.00 284 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(7), ACVR1C(3), AKT1(2), AKT2(2), AKT3(3), ARRB1(3), ARRB2(3), ATF4(1), BDNF(1), BRAF(5), CACNA1A(11), CACNA1B(14), CACNA1C(23), CACNA1D(15), CACNA1E(26), CACNA1F(2), CACNA1G(11), CACNA1H(11), CACNA1I(14), CACNA1S(10), CACNA2D1(6), CACNA2D2(5), CACNA2D3(6), CACNA2D4(9), CACNB1(1), CACNB2(10), CACNB4(3), CACNG2(1), CACNG3(3), CACNG4(3), CACNG5(3), CACNG6(1), CACNG7(5), CASP3(1), CD14(1), CDC25B(4), CDC42(1), CRK(1), DAXX(3), DDIT3(3), DUSP1(1), DUSP10(3), DUSP14(1), DUSP16(3), DUSP2(2), DUSP4(1), DUSP5(3), DUSP6(1), DUSP8(1), DUSP9(2), ECSIT(1), EGF(5), EGFR(10), ELK1(2), ELK4(4), FAS(3), FGF1(2), FGF10(4), FGF11(1), FGF12(4), FGF13(4), FGF14(4), FGF17(2), FGF18(2), FGF2(2), FGF20(1), FGF21(1), FGF22(4), FGF23(1), FGF5(1), FGF6(5), FGF7(1), FGF9(5), FGFR1(8), FGFR2(5), FGFR3(1), FGFR4(6), FLNA(11), FLNB(6), FLNC(21), GNA12(1), GNG12(1), GRB2(1), IKBKB(3), IL1B(1), IL1R1(3), IL1R2(1), JUN(2), KRAS(17), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K5(1), MAP2K6(2), MAP2K7(13), MAP3K1(8), MAP3K10(6), MAP3K12(4), MAP3K13(5), MAP3K14(3), MAP3K2(2), MAP3K3(2), MAP3K4(10), MAP3K5(3), MAP3K6(5), MAP3K7(7), MAP3K8(1), MAP4K1(2), MAP4K2(4), MAP4K3(2), MAP4K4(5), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(8), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3), MAPKAPK3(3), MAPKAPK5(2), MAPT(4), MAX(1), MEF2C(2), MKNK1(1), MOS(3), NF1(14), NFATC2(8), NFATC4(11), NFKB1(5), NFKB2(3), NLK(5), NR4A1(2), NRAS(1), NTF3(2), NTRK1(4), NTRK2(5), PAK1(4), PAK2(5), PDGFA(1), PDGFB(3), PDGFRA(4), PDGFRB(8), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PPM1A(3), PPM1B(8), PPP3CA(3), PPP3CB(1), PPP3R2(1), PPP5C(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), PTPN5(1), PTPN7(2), PTPRR(4), RAC2(1), RAC3(1), RAF1(6), RAP1A(2), RAP1B(4), RAPGEF2(9), RASA1(10), RASA2(7), RASGRF1(6), RASGRF2(10), RASGRP1(4), RASGRP2(4), RASGRP3(2), RASGRP4(3), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA4(2), RPS6KA6(7), RRAS(3), RRAS2(1), SOS1(4), SOS2(5), SRF(1), STK3(3), STK4(3), STMN1(2), TAOK1(6), TAOK2(8), TAOK3(5), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6), TNF(2), TNFRSF1A(3), TP53(67), TRAF2(2), TRAF6(4), ZAK(3) 56534466 938 118 898 289 320 290 30 176 118 4 0.000024 1.00 1.00 285 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(6), ADORA1(4), ADORA2B(1), ADORA3(2), ADRA1A(7), ADRA1B(3), ADRA2A(2), ADRA2B(2), ADRA2C(3), ADRB1(3), ADRB2(4), ADRB3(1), AGTR1(1), AGTR2(1), AVPR1A(7), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(3), C3AR1(2), C5AR1(1), CALCR(4), CALCRL(5), CCKAR(2), CCKBR(4), CHRM1(3), CHRM2(7), CHRM3(6), CHRM4(2), CHRM5(3), CNR1(5), CRHR1(2), CRHR2(3), CTSG(3), CYSLTR1(2), DRD1(3), DRD2(6), DRD3(8), DRD4(1), DRD5(10), EDNRA(3), EDNRB(13), F2(4), F2R(2), F2RL1(3), F2RL2(1), FPR1(1), FSHB(2), FSHR(17), GABBR1(8), GABBR2(5), GABRA1(5), GABRA2(5), GABRA3(5), GABRA4(4), GABRA5(5), GABRA6(5), GABRB1(2), GABRB2(4), GABRB3(6), GABRE(4), GABRG1(1), GABRG2(9), GABRG3(2), GABRP(4), GABRQ(7), GABRR1(6), GABRR2(5), GALR1(3), GALR2(1), GALR3(1), GH1(3), GH2(3), GHR(5), GHSR(4), GLP1R(1), GLP2R(4), GLRA1(2), GLRA2(1), GLRA3(2), GLRB(5), GNRHR(3), GPR156(2), GPR35(3), GPR50(5), GPR83(5), GRIA1(11), GRIA2(13), GRIA3(6), GRIA4(3), GRID1(15), GRID2(11), GRIK1(6), GRIK2(11), GRIK3(8), GRIK4(8), GRIK5(5), GRIN1(4), GRIN2A(7), GRIN2B(13), GRIN2C(4), GRIN2D(1), GRIN3A(6), GRIN3B(2), GRM1(17), GRM2(11), GRM3(5), GRM4(5), GRM5(14), GRM6(8), GRM7(12), GRM8(11), GRPR(3), GZMA(2), HCRTR1(3), HCRTR2(2), HRH1(3), HRH2(4), HRH3(3), HRH4(1), HTR1A(6), HTR1B(5), HTR1D(4), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(5), HTR2C(3), HTR4(4), HTR5A(4), HTR6(1), HTR7(4), LEPR(8), LHB(1), LHCGR(7), LTB4R(2), LTB4R2(3), MAS1(2), MC2R(2), MC3R(3), MC4R(4), MC5R(6), MCHR1(4), MCHR2(3), MLNR(2), MTNR1A(3), MTNR1B(2), NMBR(1), NMUR1(2), NMUR2(1), NPBWR1(8), NPBWR2(5), NPFFR1(1), NPFFR2(4), NPY1R(2), NPY2R(1), NPY5R(1), NR3C1(5), NTSR1(4), OPRD1(3), OPRK1(4), OPRL1(2), OXTR(4), P2RX1(1), P2RX2(5), P2RX3(2), P2RX4(1), P2RX5(2), P2RY1(5), P2RY10(3), P2RY13(4), P2RY14(2), P2RY2(1), P2RY4(2), P2RY6(3), P2RY8(6), PARD3(8), PPYR1(7), PRL(2), PRLHR(2), PRLR(2), PRSS1(3), PRSS3(2), PTAFR(2), PTGDR(5), PTGER2(2), PTGER3(2), PTGER4(1), PTGFR(3), PTH2R(4), RXFP1(5), RXFP2(6), SCTR(2), SSTR1(10), SSTR2(2), SSTR3(4), SSTR4(8), SSTR5(2), TAAR1(3), TAAR2(2), TAAR5(3), TAAR6(5), TACR1(3), TACR2(2), TACR3(6), TBXA2R(7), THRA(4), THRB(5), TRHR(6), TRPV1(6), TSHB(1), TSHR(8), UTS2R(1), VIPR1(4), VIPR2(4) 43680064 899 116 886 265 323 268 34 215 59 0 1.37e-07 1.00 1.00 286 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(4), ACTG1(2), ACTN1(3), ACTN2(15), ACTN3(2), ACTN4(1), AKT1(2), AKT2(2), AKT3(3), ARHGAP5(6), BAD(1), BCAR1(4), BCL2(1), BIRC2(2), BIRC3(4), BRAF(5), CAPN2(4), CAV1(2), CCND1(1), CCND2(1), CCND3(2), CDC42(1), CHAD(4), COL11A1(15), COL11A2(8), COL1A1(7), COL1A2(17), COL2A1(8), COL3A1(8), COL4A1(13), COL4A2(7), COL4A4(7), COL4A6(7), COL5A1(14), COL5A2(6), COL5A3(5), COL6A1(7), COL6A2(8), COL6A3(21), COL6A6(20), COMP(3), CRK(1), CTNNB1(11), DIAPH1(4), DOCK1(12), EGF(5), EGFR(10), ELK1(2), ERBB2(6), FARP2(4), FLNA(11), FLNB(6), FLNC(21), FLT1(6), FN1(21), FYN(5), GRB2(1), GRLF1(8), GSK3B(2), HGF(11), IBSP(2), IGF1(2), IGF1R(11), ILK(2), ITGA1(4), ITGA10(6), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGA7(5), ITGA8(5), ITGA9(9), ITGAV(4), ITGB1(4), ITGB3(5), ITGB4(12), ITGB5(3), ITGB6(1), ITGB7(3), ITGB8(7), JUN(2), KDR(7), LAMA1(22), LAMA2(18), LAMA3(10), LAMA4(11), LAMA5(14), LAMB1(9), LAMB2(12), LAMB3(13), LAMB4(9), LAMC1(7), LAMC2(8), LAMC3(11), MAP2K1(4), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK9(3), MET(4), MYL2(1), MYL7(1), MYLK(9), MYLK2(3), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PARVA(1), PARVB(3), PARVG(2), PDGFA(1), PDGFB(3), PDGFC(3), PDGFD(3), PDGFRA(4), PDGFRB(8), PDPK1(1), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PIP5K1C(6), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R12A(1), PRKCG(4), PTEN(8), PTK2(7), PXN(2), RAC2(1), RAC3(1), RAF1(6), RAP1A(2), RAP1B(4), RAPGEF1(6), RELN(21), RHOA(8), ROCK1(7), ROCK2(3), SHC1(3), SHC2(2), SHC3(4), SHC4(1), SOS1(4), SOS2(5), SPP1(1), THBS1(9), THBS2(7), THBS3(4), THBS4(4), TLN1(13), TLN2(22), TNC(13), TNN(12), TNR(13), TNXB(26), VASP(3), VAV1(7), VAV2(8), VAV3(6), VCL(2), VEGFC(3), VTN(4), VWF(13), ZYX(2) 73533080 1117 114 1089 466 368 376 34 224 112 3 0.65 1.00 1.00 287 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(20), APC2(6), AXIN1(7), AXIN2(3), BTRC(3), CACYBP(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CCND1(1), CCND2(1), CCND3(2), CER1(3), CHD8(9), CREBBP(13), CSNK1A1L(3), CSNK1E(6), CSNK2A1(4), CSNK2A2(1), CTBP1(2), CTBP2(4), CTNNB1(11), CTNNBIP1(1), CUL1(10), CXXC4(2), DAAM1(8), DAAM2(5), DKK1(5), DKK2(2), DKK4(2), DVL1(4), DVL2(3), DVL3(5), EP300(15), FBXW11(5), FZD1(8), FZD10(8), FZD2(3), FZD3(4), FZD4(2), FZD5(1), FZD6(8), FZD7(2), FZD8(4), GSK3B(2), JUN(2), LEF1(4), LRP5(9), LRP6(3), MAP3K7(7), MAPK10(3), MAPK8(4), MAPK9(3), MMP7(1), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NKD1(6), NKD2(1), NLK(5), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PORCN(3), PPARD(5), PPP2CA(3), PPP2CB(3), PPP2R1A(5), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(3), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRICKLE1(9), PRICKLE2(12), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), PSEN1(1), RAC2(1), RAC3(1), RHOA(8), ROCK1(7), ROCK2(3), RUVBL1(4), SENP2(3), SFRP1(3), SFRP2(2), SFRP4(2), SFRP5(1), SIAH1(1), SMAD2(8), SMAD3(2), SMAD4(9), SOX17(4), TBL1X(2), TBL1XR1(2), TCF7(2), TCF7L1(3), TCF7L2(5), TP53(67), VANGL1(3), WIF1(2), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(5), WNT3A(1), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2) 31876811 590 110 557 177 193 174 18 113 88 4 0.00048 1.00 1.00 288 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(3), ACTN1(3), ACTN2(15), ACTN3(2), ACTN4(1), APC(20), APC2(6), ARAF(6), ARHGEF1(2), ARHGEF12(6), ARHGEF4(4), ARHGEF6(10), ARHGEF7(9), ARPC1A(3), ARPC1B(1), ARPC4(1), BAIAP2(3), BCAR1(4), BDKRB1(1), BDKRB2(3), BRAF(5), CD14(1), CDC42(1), CFL1(1), CHRM1(3), CHRM2(7), CHRM3(6), CHRM4(2), CHRM5(3), CRK(1), CSK(3), CYFIP1(5), CYFIP2(9), DIAPH1(4), DIAPH2(3), DIAPH3(14), DOCK1(12), EGF(5), EGFR(10), F2(4), F2R(2), FGD1(5), FGD3(8), FGF1(2), FGF10(4), FGF11(1), FGF12(4), FGF13(4), FGF14(4), FGF17(2), FGF18(2), FGF2(2), FGF20(1), FGF21(1), FGF22(4), FGF23(1), FGF5(1), FGF6(5), FGF7(1), FGF9(5), FGFR1(8), FGFR2(5), FGFR3(1), FGFR4(6), FN1(21), GIT1(2), GNA12(1), GNG12(1), GRLF1(8), GSN(5), IQGAP1(5), IQGAP2(9), IQGAP3(10), ITGA1(4), ITGA10(6), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGA7(5), ITGA8(5), ITGA9(9), ITGAD(6), ITGAE(4), ITGAL(7), ITGAM(5), ITGAV(4), ITGAX(6), ITGB1(4), ITGB2(6), ITGB3(5), ITGB4(12), ITGB5(3), ITGB6(1), ITGB7(3), ITGB8(7), KRAS(17), LIMK1(4), LIMK2(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MOS(3), MSN(3), MYH10(16), MYH14(11), MYH9(13), MYL2(1), MYL7(1), MYLK(9), MYLK2(3), NCKAP1(6), NCKAP1L(7), NRAS(1), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PDGFA(1), PDGFB(3), PDGFRA(4), PDGFRB(8), PFN2(2), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1C(6), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R12A(1), PPP1R12B(7), PTK2(7), PXN(2), RAC2(1), RAC3(1), RAF1(6), RDX(2), RHOA(8), ROCK1(7), ROCK2(3), RRAS(3), RRAS2(1), SCIN(3), SLC9A1(6), SOS1(4), SOS2(5), SSH1(6), SSH2(13), SSH3(5), TIAM1(15), TIAM2(18), TMSL3(1), VAV1(7), VAV2(8), VAV3(6), VCL(2), WASF1(4), WASF2(2), WASL(1) 54693643 878 110 838 328 293 277 27 177 102 2 0.25 1.00 1.00 289 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(2), ATM(17), BUB1(6), BUB1B(3), BUB3(2), CCNA1(5), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(7), CCND2(1), CCND3(2), CCNE1(3), CCNE2(1), CCNH(2), CDAN1(5), CDC14A(6), CDC20(2), CDC25A(2), CDC25B(4), CDC25C(3), CDC6(2), CDC7(3), CDH1(14), CDK2(2), CDKN1A(1), CDKN2A(4), CHEK1(2), CHEK2(5), DTX4(4), E2F2(2), E2F3(1), E2F5(1), EP300(15), ESPL1(12), GSK3B(2), HDAC1(2), HDAC2(4), HDAC3(4), HDAC4(7), HDAC5(4), HDAC6(3), HDAC8(3), MAD1L1(6), MAD2L2(1), MCM2(9), MCM3(4), MCM4(6), MCM5(8), MCM6(1), MCM7(5), MDM2(3), MPEG1(5), ORC1L(10), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PLK1(5), PRKDC(22), PTPRA(5), RB1(8), RBL1(5), SKP2(4), SMAD4(9), TBC1D8(6), TFDP1(2), TGFB1(3), TP53(67), WEE1(1) 21915068 382 107 359 118 113 99 19 80 69 2 0.074 1.00 1.00 290 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY7(10), ADCY8(12), ADCY9(6), ADORA2B(1), ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRB1(3), ADRB2(4), ADRB3(1), AGTR1(1), ATP2A1(3), ATP2A2(4), ATP2A3(4), ATP2B1(8), ATP2B2(9), ATP2B3(10), ATP2B4(2), AVPR1A(7), AVPR1B(1), BDKRB1(1), BDKRB2(3), CACNA1A(11), CACNA1B(14), CACNA1C(23), CACNA1D(15), CACNA1E(26), CACNA1F(2), CACNA1G(11), CACNA1H(11), CACNA1I(14), CACNA1S(10), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CAMK4(4), CCKAR(2), CCKBR(4), CD38(2), CHRM1(3), CHRM2(7), CHRM3(6), CHRM5(3), CHRNA7(1), CYSLTR1(2), DRD1(3), EDNRA(3), EDNRB(13), EGFR(10), ERBB2(6), ERBB3(21), ERBB4(18), F2R(2), GNA11(4), GNA14(2), GNA15(2), GNAQ(1), GNAS(14), GRIN1(4), GRIN2A(7), GRIN2C(4), GRIN2D(1), GRM1(17), GRM5(14), GRPR(3), HRH1(3), HRH2(4), HTR2A(2), HTR2B(5), HTR2C(3), HTR4(4), HTR5A(4), HTR6(1), HTR7(4), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), LHCGR(7), LTB4R2(3), MYLK(9), MYLK2(3), NOS1(16), NOS3(3), NTSR1(4), OXTR(4), P2RX1(1), P2RX2(5), P2RX3(2), P2RX4(1), P2RX5(2), PDE1A(3), PDE1B(2), PDE1C(3), PDGFRA(4), PDGFRB(8), PHKA1(5), PHKA2(7), PHKB(3), PHKG1(2), PHKG2(3), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLCD1(1), PLCD3(6), PLCE1(9), PLCG1(10), PLCG2(6), PLCZ1(2), PPID(3), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), PTAFR(2), PTGER3(2), PTGFR(3), PTK2B(8), RYR1(33), RYR2(43), RYR3(40), SLC25A4(2), SLC25A5(2), SLC25A6(4), SLC8A1(6), SLC8A2(3), SLC8A3(5), SPHK1(5), TACR1(3), TACR2(2), TACR3(6), TBXA2R(7), TNNC1(3), TNNC2(1), TRHR(6), TRPC1(2), VDAC1(2), VDAC3(1) 53451592 925 107 910 322 355 293 39 159 77 2 0.0014 1.00 1.00 291 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(2), ANAPC1(14), ANAPC11(1), ANAPC2(3), ANAPC4(2), ANAPC5(2), ANAPC7(1), ATM(17), ATR(5), BUB1(6), BUB1B(3), BUB3(2), CCNA1(5), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(7), CCND1(1), CCND2(1), CCND3(2), CCNE1(3), CCNE2(1), CCNH(2), CDC14A(6), CDC16(1), CDC20(2), CDC23(4), CDC25A(2), CDC25B(4), CDC25C(3), CDC26(1), CDC27(2), CDC6(2), CDC7(3), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(4), CDKN2D(1), CHEK1(2), CHEK2(5), CREBBP(13), CUL1(10), DBF4(5), E2F2(2), E2F3(1), EP300(15), ESPL1(12), FZR1(3), GSK3B(2), HDAC1(2), HDAC2(4), MAD1L1(6), MAD2L2(1), MCM2(9), MCM3(4), MCM4(6), MCM5(8), MCM6(1), MCM7(5), MDM2(3), ORC1L(10), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PKMYT1(3), PLK1(5), PRKDC(22), RB1(8), RBL1(5), RBL2(1), SKP2(4), SMAD2(8), SMAD3(2), SMAD4(9), SMC1A(4), SMC1B(3), TFDP1(2), TGFB1(3), TGFB2(6), TGFB3(4), TP53(67), WEE1(1), YWHAG(1), YWHAH(1), YWHAQ(2), YWHAZ(1) 27083171 430 107 400 148 124 124 19 84 77 2 0.32 1.00 1.00 292 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(2), ABLIM1(3), ABLIM2(3), ABLIM3(4), ARHGEF12(6), CDC42(1), CDK5(2), CFL1(1), CXCR4(2), DCC(19), DPYSL2(1), DPYSL5(4), EFNA1(2), EFNA2(2), EFNA5(2), EFNB1(1), EFNB2(4), EFNB3(4), EPHA1(8), EPHA2(5), EPHA3(12), EPHA4(7), EPHA5(14), EPHA6(15), EPHA7(3), EPHA8(9), EPHB1(14), EPHB2(11), EPHB3(6), EPHB4(4), EPHB6(6), FES(4), FYN(5), GNAI1(1), GNAI2(3), GNAI3(5), GSK3B(2), ITGB1(4), KRAS(17), L1CAM(3), LIMK1(4), LIMK2(4), LRRC4C(5), MAPK1(2), MAPK3(1), MET(4), NCK1(3), NCK2(2), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NGEF(5), NRAS(1), NRP1(11), NTN1(3), NTN4(1), NTNG1(6), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PLXNA1(13), PLXNA2(13), PLXNA3(11), PLXNB1(8), PLXNB2(10), PLXNB3(6), PLXNC1(9), PPP3CA(3), PPP3CB(1), PPP3R2(1), PTK2(7), RAC2(1), RAC3(1), RASA1(10), RGS3(11), RHOA(8), ROBO1(13), ROBO2(13), ROBO3(6), ROCK1(7), ROCK2(3), SEMA3A(5), SEMA3B(2), SEMA3D(8), SEMA3E(7), SEMA3F(8), SEMA3G(3), SEMA4A(5), SEMA4B(3), SEMA4C(5), SEMA4D(6), SEMA4F(3), SEMA5A(13), SEMA5B(5), SEMA6A(6), SEMA6B(2), SEMA6C(4), SEMA6D(9), SEMA7A(2), SLIT1(5), SLIT2(17), SLIT3(9), SRGAP1(9), SRGAP2(6), SRGAP3(5), UNC5A(6), UNC5B(5), UNC5C(9), UNC5D(7) 38870015 658 106 637 261 193 192 47 152 73 1 0.58 1.00 1.00 293 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRB1(3), ADRB2(4), ADRB3(1), ANXA6(2), ARRB1(3), ARRB2(3), ATP1A4(10), ATP1B3(2), ATP2A2(4), ATP2A3(4), ATP2B1(8), ATP2B2(9), ATP2B3(10), CACNA1A(11), CACNA1B(14), CACNA1C(23), CACNA1D(15), CACNA1E(26), CACNA1S(10), CACNB1(1), CALM1(1), CALM2(2), CALM3(1), CALR(4), CAMK1(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CAMK4(4), CASQ1(2), CASQ2(1), CHRM1(3), CHRM2(7), CHRM3(6), CHRM4(2), CHRM5(3), GJA1(8), GJA4(4), GJA5(2), GJB3(2), GJB6(2), GNA11(4), GNAI2(3), GNAI3(5), GNAO1(1), GNAQ(1), GNAZ(6), GNB1(1), GNB2(3), GNB3(1), GNB4(4), GNG12(1), GNG7(2), GNGT1(3), GRK4(1), GRK5(1), ITPR1(17), ITPR2(18), ITPR3(16), KCNB1(5), KCNJ3(6), KCNJ5(2), MIB1(2), NME7(1), PLCB3(8), PRKACA(1), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCQ(2), PRKD1(6), RGS1(1), RGS10(2), RGS11(2), RGS14(1), RGS16(2), RGS17(1), RGS18(3), RGS19(1), RGS2(2), RGS20(2), RGS3(11), RGS5(1), RGS6(7), RGS7(2), RGS9(4), RYR1(33), RYR2(43), RYR3(40), SLC8A1(6), SLC8A3(5), USP5(4), YWHAH(1), YWHAQ(2) 37386307 633 105 626 239 244 183 30 111 65 0 0.079 1.00 1.00 294 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(4), ACTG1(2), CHAD(4), COL11A1(15), COL11A2(8), COL17A1(5), COL1A1(7), COL1A2(17), COL2A1(8), COL3A1(8), COL4A1(13), COL4A2(7), COL4A4(7), COL4A6(7), COL5A1(14), COL5A2(6), COL5A3(5), COL6A1(7), COL6A2(8), COL6A3(21), COL6A6(20), COMP(3), DES(1), DSC1(3), DSC2(4), DSC3(4), DSG1(3), DSG2(2), DSG3(6), DSG4(4), FN1(21), GJA1(8), GJA10(2), GJA3(1), GJA4(4), GJA5(2), GJA8(1), GJA9(2), GJB3(2), GJB6(2), GJC2(3), GJD2(3), GJD4(4), IBSP(2), INA(3), ITGA6(2), ITGB4(12), KRT1(2), KRT10(4), KRT12(4), KRT13(7), KRT14(2), KRT15(1), KRT16(3), KRT17(2), KRT18(3), KRT2(6), KRT20(2), KRT23(1), KRT24(1), KRT25(2), KRT27(6), KRT28(5), KRT3(3), KRT31(3), KRT32(3), KRT33A(5), KRT33B(5), KRT34(1), KRT35(2), KRT36(3), KRT37(4), KRT38(1), KRT39(4), KRT4(1), KRT40(1), KRT5(3), KRT6A(5), KRT6B(1), KRT6C(2), KRT7(3), KRT71(2), KRT72(6), KRT73(6), KRT74(3), KRT75(2), KRT76(2), KRT77(2), KRT78(3), KRT79(2), KRT8(3), KRT81(2), KRT82(3), KRT83(2), KRT84(4), KRT85(2), KRT86(1), LAMA1(22), LAMA2(18), LAMA3(10), LAMA4(11), LAMA5(14), LAMB1(9), LAMB2(12), LAMB3(13), LAMB4(9), LAMC1(7), LAMC2(8), LAMC3(11), LMNA(5), LMNB1(2), LMNB2(3), NES(3), PRPH(1), RELN(21), SPP1(1), THBS1(9), THBS2(7), THBS3(4), THBS4(4), TNC(13), TNN(12), TNR(13), TNXB(26), VIM(2), VTN(4), VWF(13) 49259252 730 100 726 317 262 216 22 165 64 1 0.82 1.00 1.00 295 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(7), CADM1(9), CADM3(5), CD2(2), CD22(1), CD226(2), CD274(1), CD276(3), CD34(2), CD4(3), CD40(1), CD40LG(4), CD58(1), CD6(5), CD80(1), CD86(2), CD8A(2), CD8B(1), CDH1(14), CDH15(2), CDH2(10), CDH3(6), CDH4(12), CDH5(4), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(3), CLDN23(3), CLDN4(4), CLDN6(1), CLDN9(3), CNTN1(10), CNTN2(4), CNTNAP1(11), CNTNAP2(15), CTLA4(3), ESAM(6), GLG1(5), HLA-A(10), HLA-B(12), HLA-C(4), HLA-DMA(2), HLA-DMB(3), HLA-DOA(1), HLA-DPA1(2), HLA-DPB1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(3), HLA-DRB1(1), HLA-E(3), HLA-F(5), HLA-G(2), ICAM1(2), ICAM2(2), ICAM3(2), ICOS(1), ITGA4(8), ITGA6(2), ITGA8(5), ITGA9(9), ITGAL(7), ITGAM(5), ITGAV(4), ITGB1(4), ITGB2(6), ITGB7(3), ITGB8(7), JAM3(3), L1CAM(3), MADCAM1(2), MAG(6), MPZ(2), NCAM1(2), NCAM2(10), NEGR1(4), NEO1(8), NFASC(10), NLGN1(7), NLGN2(5), NLGN3(8), NRCAM(5), NRXN1(16), NRXN2(13), NRXN3(12), OCLN(1), PDCD1(2), PDCD1LG2(1), PTPRC(16), PTPRF(10), PTPRM(19), PVR(3), PVRL1(2), PVRL2(3), PVRL3(3), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SELE(3), SELL(4), SELP(2), SELPLG(6), SIGLEC1(10), VCAM1(5), VCAN(25) 29178708 541 100 534 206 164 172 20 133 50 2 0.15 1.00 1.00 296 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(9), CD36(2), CD44(5), CHAD(4), COL11A1(15), COL11A2(8), COL1A1(7), COL1A2(17), COL2A1(8), COL3A1(8), COL4A1(13), COL4A2(7), COL4A4(7), COL4A6(7), COL5A1(14), COL5A2(6), COL5A3(5), COL6A1(7), COL6A2(8), COL6A3(21), COL6A6(20), DAG1(7), FN1(21), FNDC1(9), FNDC3A(7), FNDC4(2), GP5(2), GP6(4), HMMR(4), HSPG2(16), IBSP(2), ITGA1(4), ITGA10(6), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGA7(5), ITGA8(5), ITGA9(9), ITGAV(4), ITGB1(4), ITGB3(5), ITGB4(12), ITGB5(3), ITGB6(1), ITGB7(3), ITGB8(7), LAMA1(22), LAMA2(18), LAMA3(10), LAMA4(11), LAMA5(14), LAMB1(9), LAMB2(12), LAMB3(13), LAMB4(9), LAMC1(7), LAMC2(8), LAMC3(11), RELN(21), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SPP1(1), SV2A(5), SV2B(1), SV2C(4), THBS1(9), THBS2(7), THBS3(4), THBS4(4), TNC(13), TNN(12), TNR(13), TNXB(26), VTN(4), VWF(13) 44369538 665 99 660 293 230 195 20 147 72 1 0.89 1.00 1.00 297 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(17), CCNA1(5), CCNB1(1), CCND1(1), CCND2(1), CCND3(2), CCNE1(3), CCNE2(1), CCNG2(1), CCNH(2), CDC25A(2), CDK2(2), CDKN1A(1), CDKN2A(4), CDKN2D(1), CREB3(3), CREB3L1(3), CREB3L3(3), CREB3L4(1), E2F2(2), E2F3(1), E2F5(1), GBA2(2), MCM2(9), MCM3(4), MCM4(6), MCM5(8), MCM6(1), MCM7(5), MDM2(3), MNAT1(2), MYT1(12), NACA(1), ORC1L(10), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(2), POLE(14), POLE2(2), PRIM1(1), RB1(8), RBL1(5), RPA1(1), RPA2(1), RPA3(1), TFDP1(2), TFDP2(3), TNXB(26), TP53(67), WEE1(1) 15227601 269 95 248 87 98 68 9 52 40 2 0.082 1.00 1.00 298 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(4), ACTG1(2), ACTN1(3), ACTN2(15), ACTN3(2), ACTN4(1), AKT1(2), AKT2(2), AKT3(3), AMOTL1(4), ASH1L(19), CASK(3), CDC42(1), CGN(8), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(3), CLDN23(3), CLDN4(4), CLDN6(1), CLDN9(3), CSDA(5), CSNK2A1(4), CSNK2A2(1), CTNNA1(5), CTNNA2(13), CTNNA3(5), CTNNB1(11), CTTN(2), EPB41(7), EPB41L1(4), EPB41L2(8), EPB41L3(14), EXOC3(5), EXOC4(4), GNAI1(1), GNAI2(3), GNAI3(5), HCLS1(1), IGSF5(2), INADL(5), JAM3(3), KRAS(17), LLGL1(8), LLGL2(4), MAGI1(16), MAGI2(10), MAGI3(5), MLLT4(16), MPDZ(14), MPP5(1), MYH1(8), MYH10(16), MYH11(12), MYH13(15), MYH14(11), MYH15(7), MYH2(14), MYH3(19), MYH4(12), MYH6(9), MYH7(13), MYH7B(12), MYH8(13), MYH9(13), MYL2(1), MYL7(1), NRAS(1), OCLN(1), PARD3(8), PARD6B(1), PARD6G(2), PPM1J(3), PPP2CA(3), PPP2CB(3), PPP2R1A(5), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(3), PPP2R3A(5), PPP2R3B(5), PPP2R4(2), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCI(6), PRKCQ(2), PTEN(8), RAB13(2), RAB3B(3), RHOA(8), RRAS(3), RRAS2(1), SPTAN1(13), SYMPK(5), TJAP1(2), TJP1(6), TJP2(5), TJP3(4), YES1(2), ZAK(3) 38508342 618 95 601 192 202 198 18 140 59 1 0.0026 1.00 1.00 299 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTA2(5), ACTN2(15), ACTN3(2), ACTN4(1), DES(1), DMD(23), FAM48A(5), MYBPC1(5), MYBPC2(5), MYBPC3(3), MYH3(19), MYH6(9), MYH7(13), MYH8(13), MYL1(1), MYL2(1), MYL3(1), MYL4(1), MYOM1(1), NEB(31), TCAP(1), TMOD1(3), TNNC2(1), TNNI2(5), TNNI3(1), TNNT1(2), TNNT2(2), TPM1(2), TPM3(2), TPM4(3), TTN(273), VIM(2) 27341629 453 95 450 151 124 140 23 136 27 3 0.12 1.00 1.00 300 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ACTA2(5), ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ARRB1(3), ARRB2(3), ATF4(1), ATF5(3), ATP2A2(4), ATP2A3(4), CALCA(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CNN1(1), CORIN(7), CREB3(3), CRHR1(2), DGKZ(1), ETS2(1), GABPA(1), GABPB2(1), GBA2(2), GJA1(8), GNAQ(1), GNB1(1), GNB2(3), GNB3(1), GNB4(4), GNG12(1), GNG7(2), GNGT1(3), GRK4(1), GRK5(1), GUCA2A(1), GUCY1A3(11), IGFBP1(2), IGFBP2(1), IGFBP3(4), IL1B(1), IL6(1), ITPR1(17), ITPR2(18), ITPR3(16), JUN(2), MIB1(2), MYL2(1), MYL4(1), MYLK2(3), NFKB1(5), NOS1(16), NOS3(3), OXT(2), OXTR(4), PDE4B(5), PLCB3(8), PLCD1(1), PLCG1(10), PLCG2(6), PRKACA(1), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(6), PRKCH(5), PRKCQ(2), PRKD1(6), RAMP2(1), RAMP3(3), RGS1(1), RGS10(2), RGS11(2), RGS14(1), RGS16(2), RGS17(1), RGS18(3), RGS19(1), RGS2(2), RGS20(2), RGS3(11), RGS5(1), RGS6(7), RGS7(2), RGS9(4), RYR1(33), RYR2(43), RYR3(40), SLC8A1(6), SP1(3), TNXB(26), USP5(4), YWHAH(1), YWHAQ(2) 34414719 530 94 526 216 202 141 18 119 50 0 0.50 1.00 1.00 301 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(4), ADORA2B(1), ADORA3(2), ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRA2A(2), ADRA2C(3), ADRB1(3), ADRB2(4), ADRB3(1), AGTR1(1), AGTR2(1), AVPR1A(7), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(3), C3AR1(2), CCBP2(3), CCKAR(2), CCKBR(4), CCR1(2), CCR10(2), CCR2(3), CCR3(4), CCR5(1), CCR6(1), CCR8(2), CCR9(1), CCRL1(5), CHML(2), CHRM1(3), CHRM2(7), CHRM3(6), CHRM4(2), CHRM5(3), CMKLR1(1), CNR1(5), CX3CR1(4), CXCR4(2), DRD1(3), DRD2(6), DRD3(8), DRD4(1), DRD5(10), EDNRA(3), EDNRB(13), F2R(2), F2RL1(3), F2RL2(1), FPR1(1), FSHR(17), GALR1(3), GALR2(1), GALR3(1), GALT(1), GHSR(4), GPR17(1), GPR173(3), GPR174(1), GPR27(2), GPR3(3), GPR35(3), GPR37(3), GPR37L1(4), GPR4(2), GPR50(5), GPR6(7), GPR83(5), GPR85(1), GPR87(4), GRPR(3), HCRTR1(3), HCRTR2(2), HRH1(3), HRH2(4), HRH3(3), HTR1A(6), HTR1B(5), HTR1D(4), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(5), HTR2C(3), HTR4(4), HTR5A(4), HTR6(1), HTR7(4), LHCGR(7), LTB4R(2), MAS1(2), MC3R(3), MC4R(4), MC5R(6), MLNR(2), MTNR1A(3), MTNR1B(2), NMBR(1), NMUR1(2), NMUR2(1), NPY1R(2), NPY2R(1), NPY5R(1), NTSR1(4), OPN1SW(1), OPN3(2), OPRD1(3), OPRK1(4), OPRL1(2), OR10A5(1), OR11A1(3), OR12D3(1), OR1F1(1), OR1Q1(4), OR2H1(1), OR5V1(4), OR7A5(1), OR7C1(3), OR8B8(6), OXTR(4), P2RY1(5), P2RY10(3), P2RY12(8), P2RY13(4), P2RY14(2), P2RY2(1), P2RY6(3), PPYR1(7), PTAFR(2), PTGDR(5), PTGER2(2), PTGER4(1), PTGFR(3), RGR(2), RHO(2), RRH(2), SSTR1(10), SSTR2(2), SSTR3(4), SSTR4(8), SUCNR1(2), TBXA2R(7), TRHR(6) 23936325 473 93 464 162 175 140 18 107 33 0 0.0041 1.00 1.00 302 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(4), ACVR1B(7), ACVR2A(18), ACVR2B(3), AMHR2(3), BMP2(2), BMP7(2), BMPR1A(1), BMPR1B(3), BMPR2(10), CCL11(1), CCL15(1), CCL18(2), CCL2(1), CCL20(1), CCL23(1), CCL25(1), CCL27(1), CCL5(1), CCL7(1), CCL8(2), CCR1(2), CCR2(3), CCR3(4), CCR5(1), CCR6(1), CCR8(2), CCR9(1), CD27(2), CD40(1), CD40LG(4), CD70(1), CLCF1(1), CNTF(2), CNTFR(3), CSF1R(7), CSF2RA(6), CSF2RB(7), CSF3(1), CSF3R(6), CX3CL1(5), CX3CR1(4), CXCL16(2), CXCL2(1), CXCL9(1), CXCR4(2), CXCR6(1), EDA(1), EDAR(5), EGF(5), EGFR(10), EPOR(2), FAS(3), FLT1(6), FLT3(7), FLT4(8), GDF5(5), GH1(3), GH2(3), GHR(5), HGF(11), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(5), IFNAR2(4), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), IFNK(1), IFNW1(1), IL10(1), IL10RA(2), IL10RB(1), IL11(2), IL11RA(2), IL12B(2), IL12RB1(4), IL12RB2(5), IL13(2), IL13RA1(2), IL15RA(1), IL17B(1), IL17RA(6), IL17RB(1), IL18R1(2), IL18RAP(2), IL1B(1), IL1R1(3), IL1R2(1), IL1RAP(3), IL2(1), IL20(1), IL20RA(3), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(5), IL25(2), IL26(1), IL28A(2), IL28B(3), IL2RA(1), IL2RG(3), IL3(1), IL3RA(4), IL4R(1), IL5RA(1), IL6(1), IL6ST(2), IL7R(3), IL8(1), INHBA(6), INHBB(9), INHBC(1), INHBE(1), KDR(7), KIT(6), KITLG(3), LEPR(8), LIF(2), LIFR(7), LTA(2), LTBR(2), MET(4), NGFR(5), OSM(4), OSMR(3), PDGFB(3), PDGFC(3), PDGFRA(4), PDGFRB(8), PF4V1(1), PRL(2), PRLR(2), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6), TNF(2), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(2), TNFRSF10D(2), TNFRSF11A(4), TNFRSF11B(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF19(3), TNFRSF1A(3), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(2), TNFRSF8(2), TNFRSF9(3), TNFSF10(2), TNFSF11(1), TNFSF15(1), TNFSF18(2), TNFSF8(1), TPO(13), TSLP(4), VEGFC(3), XCL1(1), XCR1(3) 34994938 508 93 489 196 148 158 24 114 62 2 0.43 1.00 1.00 303 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(4), ACTG1(2), ACTN1(3), ACTN2(15), ACTN3(2), ACTN4(1), ACVR1B(7), ACVR1C(3), BAIAP2(3), CDC42(1), CDH1(14), CREBBP(13), CSNK2A1(4), CSNK2A2(1), CTNNA1(5), CTNNA2(13), CTNNA3(5), CTNNB1(11), CTNND1(7), EGFR(10), EP300(15), ERBB2(6), FARP2(4), FER(7), FGFR1(8), FYN(5), IGF1R(11), INSR(10), IQGAP1(5), LEF1(4), LMO7(9), MAP3K7(7), MAPK1(2), MAPK3(1), MET(4), MLLT4(16), NLK(5), PARD3(8), PTPN6(3), PTPRB(12), PTPRF(10), PTPRJ(14), PTPRM(19), PVRL1(2), PVRL2(3), PVRL3(3), PVRL4(4), RAC2(1), RAC3(1), RHOA(8), SMAD2(8), SMAD3(2), SMAD4(9), SNAI1(2), SNAI2(4), SORBS1(7), SSX2IP(3), TCF7(2), TCF7L1(3), TCF7L2(5), TGFBR1(2), TGFBR2(6), TJP1(6), VCL(2), WASF1(4), WASF2(2), WASF3(3), WASL(1), YES1(2) 23728242 404 90 393 133 113 136 13 81 61 0 0.045 1.00 1.00 304 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(1), BAK1(2), BFAR(1), BTK(2), CAD(7), CASP10(3), CASP3(1), CASP8(6), CASP8AP2(9), CD7(4), DAXX(3), DEDD(1), DEDD2(2), DFFA(2), DIABLO(1), EGFR(10), EPHB2(11), FAF1(4), FAIM2(1), HSPB1(1), IL8(1), MAP2K4(5), MAP2K7(13), MAP3K1(8), MAP3K5(3), MAPK1(2), MAPK10(3), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3), MET(4), NFAT5(5), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), NR0B2(2), PFN2(2), PTPN13(14), RALBP1(7), ROCK1(7), SMPD1(4), TP53(67), TPX2(4), TRAF2(2), TUFM(3) 14504814 264 90 241 80 84 68 9 54 48 1 0.061 1.00 1.00 305 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(3), ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ADK(1), ADSL(4), ADSS(3), ADSSL1(7), AK5(3), AK7(2), ALLC(3), AMPD1(3), AMPD2(5), AMPD3(7), APRT(2), ATIC(5), CANT1(4), DCK(1), DGUOK(1), ENPP1(1), ENPP3(3), ENTPD1(3), ENTPD3(3), ENTPD4(6), ENTPD6(1), ENTPD8(4), FHIT(1), GART(6), GDA(1), GMPR(3), GMPR2(2), GMPS(3), GUCY1A2(6), GUCY1A3(11), GUCY1B3(7), GUCY2C(6), GUCY2D(8), GUCY2F(7), GUK1(2), IMPDH1(1), IMPDH2(1), NME6(3), NME7(1), NPR1(6), NPR2(5), NT5C(1), NT5C1A(1), NT5C1B(4), NT5C2(5), NUDT2(2), NUDT5(1), NUDT9(1), PAPSS1(4), PAPSS2(2), PDE10A(1), PDE11A(2), PDE1A(3), PDE1C(3), PDE2A(6), PDE3B(10), PDE4A(4), PDE4B(5), PDE4C(2), PDE5A(5), PDE6G(1), PDE7A(5), PDE7B(3), PDE8A(6), PDE8B(3), PDE9A(5), PFAS(2), PKLR(4), PKM2(2), PNPT1(3), POLA1(4), POLA2(2), POLD1(7), POLD3(2), POLE(14), POLE2(2), POLE3(1), POLE4(1), POLR1A(8), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(6), POLR3G(1), POLR3K(1), PPAT(1), PRIM1(1), PRIM2(3), PRPS1(1), PRPS1L1(2), PRPS2(3), PRUNE(3), RRM1(4), RRM2(2), RRM2B(2), XDH(9) 32387372 433 89 432 163 144 153 16 91 29 0 0.27 1.00 1.00 306 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ADRB1(3), CSNK1D(2), DRD1(3), DRD2(6), EGF(5), EGFR(10), GJA1(8), GJD2(3), GNA11(4), GNAI1(1), GNAI2(3), GNAI3(5), GNAQ(1), GNAS(14), GRB2(1), GRM1(17), GRM5(14), GUCY1A2(6), GUCY1A3(11), GUCY1B3(7), GUCY2C(6), GUCY2D(8), GUCY2F(7), HTR2A(2), HTR2B(5), HTR2C(3), ITPR1(17), ITPR2(18), ITPR3(16), KRAS(17), MAP2K1(4), MAP2K2(1), MAP2K5(1), MAP3K2(2), MAPK1(2), MAPK3(1), MAPK7(8), NPR1(6), NPR2(5), NRAS(1), PDGFA(1), PDGFB(3), PDGFC(3), PDGFD(3), PDGFRA(4), PDGFRB(8), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKG1(6), PRKG2(6), PRKX(2), RAF1(6), SOS1(4), SOS2(5), TJP1(6), TUBA1B(1), TUBA1C(2), TUBA3C(6), TUBA3D(5), TUBA3E(5), TUBA8(3), TUBAL3(3), TUBB1(4), TUBB2A(2), TUBB2C(2), TUBB3(8), TUBB4(1), TUBB4Q(2), TUBB6(5), TUBB8(2) 26203303 473 87 460 170 161 152 24 106 30 0 0.10 1.00 1.00 307 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(2), AKT2(2), AKT3(3), BCL10(1), CARD11(12), CBL(2), CBLB(2), CBLC(2), CD247(2), CD3E(3), CD3G(2), CD4(3), CD40LG(4), CD8A(2), CD8B(1), CDC42(1), CTLA4(3), FYN(5), GRAP2(1), GRB2(1), ICOS(1), IFNG(2), IKBKB(3), IL10(1), IL2(1), ITK(4), JUN(2), KRAS(17), LCK(1), LCP2(7), MALT1(5), MAP3K14(3), MAP3K8(1), NCK1(3), NCK2(2), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NFKB1(5), NFKB2(3), NFKBIB(4), NRAS(1), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PDCD1(2), PDK1(1), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLCG1(10), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKCQ(2), PTPN6(3), PTPRC(16), RASGRP1(4), RHOA(8), SOS1(4), SOS2(5), TEC(3), TNF(2), VAV1(7), VAV2(8), VAV3(6), ZAP70(4) 20078978 341 86 309 116 82 131 10 83 35 0 0.13 1.00 1.00 308 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(2), AKT2(2), AKT3(3), CBL(2), CBLB(2), CBLC(2), CCND1(1), CCND2(1), CCND3(2), CISH(2), CLCF1(1), CNTF(2), CNTFR(3), CREBBP(13), CSF2RA(6), CSF2RB(7), CSF3(1), CSF3R(6), EP300(15), EPOR(2), GH1(3), GH2(3), GHR(5), GRB2(1), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(5), IFNAR2(4), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), IFNK(1), IFNW1(1), IL10(1), IL10RA(2), IL10RB(1), IL11(2), IL11RA(2), IL12B(2), IL12RB1(4), IL12RB2(5), IL13(2), IL13RA1(2), IL13RA2(7), IL15RA(1), IL2(1), IL20(1), IL20RA(3), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(5), IL26(1), IL28A(2), IL28B(3), IL2RA(1), IL2RG(3), IL3(1), IL3RA(4), IL4R(1), IL5RA(1), IL6(1), IL6ST(2), IL7R(3), IRF9(4), JAK1(4), JAK2(8), JAK3(3), LEPR(8), LIF(2), LIFR(7), OSM(4), OSMR(3), PIAS1(3), PIAS2(5), PIAS3(1), PIAS4(4), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PIM1(2), PRL(2), PRLR(2), PTPN11(4), PTPN6(3), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(3), SOCS7(2), SOS1(4), SOS2(5), SPRED1(3), SPRED2(6), SPRY1(2), SPRY2(1), SPRY3(4), SPRY4(3), STAM(4), STAM2(3), STAT1(6), STAT2(4), STAT3(7), STAT4(4), STAT5A(1), STAT5B(4), TPO(13), TSLP(4), TYK2(6) 28754939 428 85 410 143 113 157 20 94 43 1 0.054 1.00 1.00 309 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), AKAP1(1), AKAP10(2), AKAP11(5), AKAP12(5), AKAP3(5), AKAP4(8), AKAP6(11), AKAP7(6), AKAP8(7), AKAP9(16), ARHGEF1(2), CALM1(1), CALM2(2), CALM3(1), CHMP1B(2), GNA11(4), GNA12(1), GNA14(2), GNA15(2), GNAI2(3), GNAI3(5), GNAO1(1), GNAQ(1), GNAZ(6), GNB1(1), GNB2(3), GNB3(1), GNG12(1), GNG7(2), GNGT1(3), GNGT2(1), ITPR1(17), KCNJ3(6), KRAS(17), NRAS(1), PDE1A(3), PDE1B(2), PDE1C(3), PDE4A(4), PDE4B(5), PDE4C(2), PDE7A(5), PDE7B(3), PDE8A(6), PDE8B(3), PLCB3(8), PPP3CA(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCI(6), PRKCQ(2), PRKD1(6), PRKD3(1), RHOA(8), RRAS(3), SLC9A1(6), USP5(4) 23201314 338 84 318 123 111 115 10 65 37 0 0.14 1.00 1.00 310 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ATF4(1), CACNA1C(23), CACNA1D(15), CACNA1F(2), CACNA1S(10), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CDC42(1), EGFR(10), ELK1(2), FSHB(2), GNA11(4), GNAQ(1), GNAS(14), GNRH1(1), GNRH2(1), GNRHR(3), GRB2(1), ITPR1(17), ITPR2(18), ITPR3(16), JUN(2), KRAS(17), LHB(1), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(13), MAP3K1(8), MAP3K2(2), MAP3K3(2), MAP3K4(10), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(8), MAPK8(4), MAPK9(3), MMP14(1), MMP2(4), NRAS(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLD1(7), PLD2(11), PRKACA(1), PRKACB(2), PRKACG(3), PRKCD(3), PRKX(2), PTK2B(8), RAF1(6), SOS1(4), SOS2(5) 25251762 425 84 414 141 143 146 15 77 44 0 0.015 1.00 1.00 311 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ASIP(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CREB1(4), CREB3(3), CREB3L1(3), CREB3L2(1), CREB3L3(3), CREB3L4(1), CREBBP(13), CTNNB1(11), DCT(7), DVL1(4), DVL2(3), DVL3(5), EDN1(3), EDNRB(13), EP300(15), FZD1(8), FZD10(8), FZD2(3), FZD3(4), FZD4(2), FZD5(1), FZD6(8), FZD7(2), FZD8(4), GNAI1(1), GNAI2(3), GNAI3(5), GNAO1(1), GNAQ(1), GNAS(14), GSK3B(2), KIT(6), KITLG(3), KRAS(17), LEF1(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MITF(6), NRAS(1), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), POMC(5), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), RAF1(6), TCF7(2), TCF7L1(3), TCF7L2(5), TYR(5), TYRP1(5), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(5), WNT3A(1), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2) 21429050 399 84 383 153 139 126 12 77 44 1 0.19 1.00 1.00 312 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(15), ACACB(13), AKT1(2), AKT2(2), AKT3(3), ARAF(6), BAD(1), BRAF(5), CALM1(1), CALM2(2), CALM3(1), CBL(2), CBLB(2), CBLC(2), CRK(1), EIF4EBP1(1), ELK1(2), EXOC7(6), FASN(11), FBP1(1), FBP2(3), FLOT1(1), FLOT2(3), FOXO1(1), GCK(3), GRB2(1), GSK3B(2), GYS1(4), GYS2(2), IKBKB(3), INPP5D(1), INSR(10), IRS1(7), IRS2(3), IRS4(11), KRAS(17), LIPE(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK9(3), MKNK1(1), NRAS(1), PCK1(4), PCK2(6), PDE3A(8), PDE3B(10), PDPK1(1), PFKL(7), PFKM(3), PFKP(8), PHKA1(5), PHKA2(7), PHKB(3), PHKG1(2), PHKG2(3), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PKLR(4), PKM2(2), PPARGC1A(6), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R3A(12), PPP1R3B(5), PPP1R3C(3), PPP1R3D(3), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAB2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAG3(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKCI(6), PRKX(2), PTPRF(10), PYGB(4), PYGL(5), PYGM(7), RAF1(6), RAPGEF1(6), RHEB(1), RPS6(1), RPS6KB1(3), RPS6KB2(3), SH2B2(3), SHC1(3), SHC2(2), SHC3(4), SHC4(1), SLC2A4(1), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(3), SORBS1(7), SOS1(4), SOS2(5), SREBF1(4), TRIP10(7), TSC1(4), TSC2(4) 31585310 498 83 473 184 155 181 18 94 49 1 0.14 1.00 1.00 313 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(1), CALM2(2), CALM3(1), CDS1(4), CDS2(1), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKI(5), DGKQ(2), DGKZ(1), FN3K(2), IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(3), INPP5B(2), INPP5D(1), INPP5E(2), INPPL1(13), ITGB1BP3(3), ITPK1(2), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), OCRL(4), PI4KA(10), PI4KB(4), PIK3C2A(4), PIK3C2B(12), PIK3C2G(3), PIK3C3(8), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1C(6), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLCD1(1), PLCD3(6), PLCE1(9), PLCG1(10), PLCG2(6), PLCZ1(2), PRKCG(4), PTEN(8), PTPMT1(1), SYNJ1(7), SYNJ2(15) 24750947 373 82 351 119 116 127 13 74 42 1 0.023 1.00 1.00 314 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(4), ACVR1B(7), ACVR1C(3), ACVR2A(18), ACVR2B(3), ACVRL1(2), AMHR2(3), BMP2(2), BMP4(6), BMP5(6), BMP6(5), BMP7(2), BMP8A(1), BMP8B(2), BMPR1A(1), BMPR1B(3), BMPR2(10), CHRD(1), COMP(3), CREBBP(13), CUL1(10), DCN(2), E2F5(1), EP300(15), FST(1), GDF5(5), GDF6(6), GDF7(1), IFNG(2), INHBA(6), INHBB(9), INHBC(1), INHBE(1), LEFTY2(2), LTBP1(12), MAPK1(2), MAPK3(1), PITX2(2), PPP2CA(3), PPP2CB(3), PPP2R1A(5), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(3), RBL1(5), RBL2(1), RHOA(8), ROCK1(7), ROCK2(3), RPS6KB1(3), RPS6KB2(3), SMAD1(1), SMAD2(8), SMAD3(2), SMAD4(9), SMAD5(1), SMAD6(3), SMAD7(2), SMAD9(6), SMURF1(1), SMURF2(1), SP1(3), TFDP1(2), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6), THBS1(9), THBS2(7), THBS3(4), THBS4(4), TNF(2), ZFYVE16(6), ZFYVE9(2) 19520020 322 82 298 116 109 91 15 51 54 2 0.30 1.00 1.00 315 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(3), ACTN2(15), ACTN3(2), ACTN4(1), ARHGAP5(6), BCAR1(4), CDC42(1), CDH5(4), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(3), CLDN23(3), CLDN4(4), CLDN6(1), CLDN9(3), CTNNA1(5), CTNNA2(13), CTNNA3(5), CTNNB1(11), CTNND1(7), CXCR4(2), CYBA(1), CYBB(4), ESAM(6), GNAI1(1), GNAI2(3), GNAI3(5), GRLF1(8), ICAM1(2), ITGA4(8), ITGAL(7), ITGAM(5), ITGB1(4), ITGB2(6), ITK(4), JAM3(3), MAPK11(1), MAPK13(1), MAPK14(1), MLLT4(16), MMP2(4), MMP9(6), MSN(3), MYL2(1), MYL7(1), NCF1(2), NCF2(1), NCF4(1), NOX1(4), NOX3(3), OCLN(1), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLCG1(10), PLCG2(6), PRKCG(4), PTK2(7), PTK2B(8), PTPN11(4), PXN(2), RAC2(1), RAP1A(2), RAP1B(4), RAPGEF3(2), RAPGEF4(3), RASSF5(1), RHOA(8), RHOH(1), ROCK1(7), ROCK2(3), TXK(1), VASP(3), VAV1(7), VAV2(8), VAV3(6), VCAM1(5), VCL(2) 24584043 403 81 378 157 131 138 15 74 44 1 0.38 1.00 1.00 316 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(4), ACVR1B(7), ACVRL1(2), AKT1(2), AURKB(2), BMPR1A(1), BMPR2(10), BUB1(6), CDKL1(3), CDKL2(3), CDS1(4), CDS2(1), CLK1(3), CLK2(6), CLK4(3), COL4A3BP(1), CSNK2A1(4), CSNK2A2(1), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKQ(2), DGKZ(1), IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(3), INPPL1(13), ITPKA(1), ITPKB(6), MAP3K10(6), MOS(3), NEK1(4), NEK3(1), OCRL(4), PAK4(5), PIK3C2A(4), PIK3C2B(12), PIK3C2G(3), PIK3CA(33), PIK3CB(6), PIK3CG(10), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLCD1(1), PLCG1(10), PLCG2(6), PLK3(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCQ(2), PRKD1(6), PRKG1(6), RAF1(6), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA4(2), RPS6KB1(3), TGFBR1(2), VRK1(2) 22409505 342 81 322 111 99 113 13 76 38 3 0.12 1.00 1.00 317 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(11), ADCY8(12), ARAF(6), ATF4(1), BRAF(5), CACNA1C(23), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CAMK4(4), CREBBP(13), EP300(15), GNAQ(1), GRIA1(11), GRIA2(13), GRIN1(4), GRIN2A(7), GRIN2B(13), GRIN2C(4), GRIN2D(1), GRM1(17), GRM5(14), ITPR1(17), ITPR2(18), ITPR3(16), KRAS(17), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), NRAS(1), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R12A(1), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), RAF1(6), RAP1A(2), RAP1B(4), RAPGEF3(2), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA6(7) 19778105 353 80 343 116 108 128 13 62 42 0 0.028 1.00 1.00 318 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(6), BRAF(5), CACNA1A(11), CRHR1(2), GNA11(4), GNA12(1), GNAI1(1), GNAI2(3), GNAI3(5), GNAO1(1), GNAQ(1), GNAS(14), GNAZ(6), GRIA1(11), GRIA2(13), GRIA3(6), GRID2(11), GRM1(17), GRM5(14), GUCY1A2(6), GUCY1A3(11), GUCY1B3(7), GUCY2C(6), GUCY2D(8), GUCY2F(7), IGF1(2), IGF1R(11), ITPR1(17), ITPR2(18), ITPR3(16), KRAS(17), LYN(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), NOS1(16), NOS3(3), NPR1(6), NPR2(5), NRAS(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PPP2CA(3), PPP2CB(3), PPP2R1A(5), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(3), PRKCG(4), PRKG1(6), PRKG2(6), RAF1(6), RYR1(33) 21830202 433 80 420 128 148 131 21 102 31 0 0.0038 1.00 1.00 319 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(2), ABL2(3), AKT1(2), AKT2(2), AKT3(3), ARAF(6), BAD(1), BRAF(5), BTC(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CBL(2), CBLB(2), CBLC(2), CDKN1A(1), CRK(1), EGF(5), EGFR(10), EIF4EBP1(1), ELK1(2), ERBB2(6), ERBB3(21), ERBB4(18), EREG(2), GAB1(1), GRB2(1), GSK3B(2), JUN(2), KRAS(17), MAP2K1(4), MAP2K2(1), MAP2K4(5), MAP2K7(13), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK9(3), NCK1(3), NCK2(2), NRAS(1), NRG1(9), NRG2(5), NRG3(9), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLCG1(10), PLCG2(6), PRKCG(4), PTK2(7), RAF1(6), RPS6KB1(3), RPS6KB2(3), SHC1(3), SHC2(2), SHC3(4), SHC4(1), SOS1(4), SOS2(5), STAT5A(1), STAT5B(4), TGFA(2) 20317623 353 79 322 115 94 131 15 72 41 0 0.042 1.00 1.00 320 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 125 ARAF(6), BID(1), BRAF(5), CASP3(1), CD244(1), CD247(2), FAS(3), FCGR3A(1), FCGR3B(2), FYN(5), GRB2(1), HLA-A(10), HLA-B(12), HLA-C(4), HLA-E(3), HLA-G(2), ICAM1(2), ICAM2(2), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(5), IFNAR2(4), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), ITGAL(7), ITGB2(6), KIR2DL1(4), KIR2DL3(1), KIR2DL4(3), KIR3DL1(2), KLRC1(2), KLRC2(2), KLRD1(2), KRAS(17), LCK(1), LCP2(7), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MICB(1), NCR1(1), NCR2(3), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NRAS(1), PAK1(4), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLCG1(10), PLCG2(6), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRF1(1), PRKCG(4), PTK2B(8), PTPN11(4), PTPN6(3), RAC2(1), RAC3(1), RAF1(6), SH2D1A(1), SH2D1B(1), SH3BP2(3), SHC1(3), SHC2(2), SHC3(4), SHC4(1), SOS1(4), SOS2(5), SYK(3), TNF(2), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(2), TNFRSF10D(2), TNFSF10(2), ULBP1(2), ULBP3(1), VAV1(7), VAV2(8), VAV3(6), ZAP70(4) 22304147 391 79 364 117 93 149 18 79 50 2 0.0034 1.00 1.00 321 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(3), ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADK(1), ADSL(4), ADSS(3), AK5(3), ALLC(3), AMPD1(3), AMPD2(5), AMPD3(7), APRT(2), ATIC(5), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5G3(1), ATP5J(1), ATP5J2(1), CANT1(4), DCK(1), DGUOK(1), ENPP1(1), ENPP3(3), ENTPD1(3), FHIT(1), GART(6), GDA(1), GMPS(3), GUCY1A2(6), GUCY1A3(11), GUCY1B3(7), GUCY2C(6), GUCY2D(8), GUCY2F(7), GUK1(2), IMPDH1(1), IMPDH2(1), NPR1(6), NPR2(5), NT5C(1), NUDT2(2), PAPSS1(4), PAPSS2(2), PDE1A(3), PDE4A(4), PDE4B(5), PDE4C(2), PDE5A(5), PDE6B(7), PDE6C(2), PDE6G(1), PDE7B(3), PDE8A(6), PDE9A(5), PFAS(2), PKLR(4), PKM2(2), POLD1(7), POLE(14), POLG(4), POLL(1), POLQ(14), POLR1B(2), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(9), PPAT(1), PRPS1(1), PRPS1L1(2), PRPS2(3), PRUNE(3), RRM1(4), RRM2(2) 25367375 338 79 337 139 106 124 13 73 22 0 0.62 1.00 1.00 322 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(2), ACTN1(3), ACTR2(2), AKT1(2), AKT2(2), AKT3(3), ANGPTL2(4), ARHGEF6(10), ARHGEF7(9), BCAR1(4), BRAF(5), CAV1(2), CDC42(1), CDKN2A(4), CRK(1), CSE1L(3), DOCK1(12), EPHB2(11), FYN(5), GRB2(1), GRB7(6), GRLF1(8), ILK(2), ITGA1(4), ITGA10(6), ITGA11(6), ITGA2(4), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGA7(5), ITGA8(5), ITGA9(9), ITGB3BP(1), MAP2K4(5), MAP2K7(13), MAP3K11(3), MAPK1(2), MAPK10(3), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3), MYLK(9), MYLK2(3), P4HB(4), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PIK3CA(33), PIK3CB(6), PKLR(4), PLCG1(10), PLCG2(6), PTEN(8), PTK2(7), RAF1(6), RHO(2), ROCK1(7), ROCK2(3), SHC1(3), SOS1(4), SOS2(5), TERF2IP(3), TLN1(13), TLN2(22), VASP(3), ZYX(2) 24258823 391 78 373 127 125 123 15 77 51 0 0.048 1.00 1.00 323 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), AKT3(3), BCAR1(4), CAPN1(3), CAPN10(1), CAPN11(3), CAPN2(4), CAPN3(5), CAPN5(2), CAPN6(8), CAPN7(5), CAPN9(3), CAPNS1(1), CAV1(2), CDC42(1), CRK(1), CSK(3), DOCK1(12), FYN(5), GIT2(1), GRB2(1), ILK(2), ITGA10(6), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGA7(5), ITGA8(5), ITGA9(9), ITGAD(6), ITGAE(4), ITGAL(7), ITGAM(5), ITGAV(4), ITGAX(6), ITGB1(4), ITGB2(6), ITGB3(5), ITGB4(12), ITGB5(3), ITGB6(1), ITGB7(3), ITGB8(7), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K6(2), MAPK10(3), MAPK4(4), MAPK6(1), MAPK7(8), MYLK2(3), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PDPK1(1), PIK3R2(4), PTK2(7), PXN(2), RAC2(1), RAC3(1), RAP1B(4), RAPGEF1(6), RHO(2), ROCK1(7), ROCK2(3), SHC1(3), SHC3(4), SORBS1(7), SOS1(4), TLN1(13), TNS1(15), VASP(3), VAV2(8), VAV3(6), VCL(2), ZYX(2) 26589722 357 77 355 149 122 105 15 70 44 1 0.75 1.00 1.00 324 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(3), ALG1(3), ALG10(5), ALG10B(2), ALG12(1), ALG13(2), ALG2(1), ALG3(2), ALG8(1), ALG9(2), B3GNT1(1), B3GNT2(1), B3GNT7(4), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), B4GALT5(3), B4GALT7(1), C1GALT1(1), C1GALT1C1(4), CHPF(2), CHST1(11), CHST11(1), CHST12(6), CHST13(1), CHST2(8), CHST3(1), CHST6(5), CHST7(1), CHSY1(3), EXT1(9), EXT2(6), EXTL1(4), EXTL2(2), EXTL3(8), FUT11(2), FUT8(3), GALNT1(3), GALNT10(3), GALNT11(5), GALNT12(2), GALNT13(3), GALNT14(6), GALNT2(3), GALNT3(1), GALNT4(1), GALNT5(4), GALNT6(2), GALNT8(5), GALNT9(3), GALNTL1(2), GALNTL2(6), GALNTL4(5), GALNTL5(4), GANAB(3), GCNT1(1), GCNT3(2), GCNT4(2), HS2ST1(1), HS3ST1(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), HS3ST5(4), HS6ST1(2), HS6ST2(1), HS6ST3(4), MAN1A2(1), MAN1B1(2), MAN1C1(3), MAN2A1(7), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(1), MGAT5(6), MGAT5B(3), NDST1(8), NDST2(5), NDST3(5), NDST4(10), OGT(2), RPN1(1), RPN2(3), ST3GAL1(3), ST3GAL2(4), ST3GAL3(2), ST3GAL4(3), ST6GALNAC1(2), STT3B(5), UST(5), WBSCR17(14), XYLT1(7), XYLT2(4) 21750585 327 76 322 136 121 102 12 67 25 0 0.74 1.00 1.00 325 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(2), AKT2(2), AKT3(3), CASP8(6), CCL5(1), CD14(1), CD40(1), CD80(1), CD86(2), CXCL9(1), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(5), IFNAR2(4), IFNB1(2), IKBKB(3), IKBKE(5), IL12B(2), IL1B(1), IL6(1), IL8(1), IRAK1(5), IRAK4(3), IRF3(3), IRF5(2), IRF7(1), JUN(2), LY96(1), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(13), MAP3K7(7), MAP3K8(1), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), MAPK9(3), MYD88(2), NFKB1(5), NFKB2(3), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), RELA(2), SPP1(1), STAT1(6), TBK1(2), TICAM1(6), TIRAP(2), TLR1(5), TLR2(3), TLR3(2), TLR4(13), TLR5(4), TLR6(3), TLR7(3), TLR8(6), TLR9(10), TNF(2), TOLLIP(1), TRAF3(2), TRAF6(4) 17728133 286 76 265 90 75 98 18 62 33 0 0.041 1.00 1.00 326 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(2), AKT2(2), AKT3(3), BAD(1), CDC42(1), CDK2(2), CDKN2A(4), CREB1(4), CREB3(3), CREB5(2), EBP(1), ERBB4(18), F2RL2(1), GAB1(1), GRB2(1), GSK3A(1), GSK3B(2), IGF1(2), IGFBP1(2), INPPL1(13), IRS1(7), IRS2(3), IRS4(11), MET(4), NOLC1(7), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PARD3(8), PDK1(1), PIK3CA(33), PIK3CD(8), PPP1R13B(6), PREX1(9), PTEN(8), PTK2(7), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KB1(3), SHC1(3), SLC2A4(1), SOS1(4), SOS2(5), TSC1(4), TSC2(4), YWHAG(1), YWHAH(1), YWHAQ(2), YWHAZ(1) 15261438 241 76 224 80 75 85 13 37 31 0 0.072 1.00 1.00 327 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(13), BDKRB1(1), BDKRB2(3), C1QA(1), C1QC(3), C1R(5), C1S(4), C2(2), C3(16), C3AR1(2), C5(9), C5AR1(1), C6(8), C7(2), C8A(6), C8B(8), C9(3), CD46(1), CD55(1), CD59(1), CFB(3), CFH(12), CFI(3), CPB2(4), CR1(17), CR2(4), F10(3), F11(3), F12(2), F13A1(9), F13B(8), F2(4), F2R(2), F3(1), F5(9), F7(6), F8(13), F9(4), FGA(5), FGB(3), FGG(2), KLKB1(4), KNG1(4), MASP1(4), MASP2(2), MBL2(1), PLAT(2), PLAU(2), PLG(10), PROC(3), PROS1(6), SERPINA1(4), SERPINA5(1), SERPINC1(2), SERPIND1(3), SERPINE1(2), SERPINF2(6), SERPING1(6), TFPI(3), THBD(1), VWF(13) 17979520 286 75 283 76 78 85 8 79 33 3 0.0035 1.00 1.00 328 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(2), BCL2(1), EGFR(10), IGF1R(11), POLR2A(9), PPP2CA(3), RB1(8), TEP1(14), TERF1(1), TERT(3), TNKS(6), TP53(67), XRCC5(3) 5582950 138 75 118 41 41 42 4 23 27 1 0.059 1.00 1.00 329 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(19), ASH2L(3), C17orf79(2), CARM1(2), CTCFL(5), DOT1L(9), EED(2), EHMT1(7), EHMT2(4), EZH1(2), EZH2(4), FBXO11(6), HCFC1(11), HSF4(2), JMJD4(1), JMJD6(1), KDM6A(6), MEN1(3), MLL(16), MLL2(32), MLL3(36), MLL4(24), MLL5(11), NSD1(13), OGT(2), PAXIP1(6), PPP1CA(2), PPP1CB(1), PPP1CC(2), PRDM2(15), PRDM9(9), PRMT1(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), RBBP5(1), SATB1(8), SETD1A(7), SETD2(4), SETDB1(12), SETDB2(3), SMYD3(2), STK38(1), SUV39H1(4), SUV39H2(1), SUV420H1(4), SUV420H2(1), SUZ12(4), WHSC1(7), WHSC1L1(7) 23513953 335 73 330 116 103 94 7 69 55 7 0.45 1.00 1.00 330 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(4), BAD(1), BCL2(1), CABIN1(8), CALM1(1), CALM2(2), CALM3(1), CAMK2B(2), CAMK4(4), CD3E(3), CD3G(2), CDKN1A(1), CNR1(5), CREBBP(13), CSNK2A1(4), CTLA4(3), EGR2(3), EGR3(1), EP300(15), FCER1A(1), FCGR3A(1), GATA3(3), GATA4(3), GRLF1(8), GSK3A(1), GSK3B(2), ICOS(1), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL13(2), IL1B(1), IL2(1), IL2RA(1), IL3(1), IL6(1), IL8(1), ITK(4), KPNA5(5), MAP2K7(13), MAPK14(1), MAPK8(4), MAPK9(3), MEF2A(1), MEF2B(3), MEF2D(6), MYF5(2), NCK2(2), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NFKB2(3), NFKBIB(4), NPPB(1), NUP214(12), OPRD1(3), PAK1(4), PIN1(1), PPP3CB(1), PTPRC(16), RELA(2), RPL13A(1), SLA(1), SP1(3), SP3(3), TGFB1(3), TNF(2), TRAF2(2), TRPV6(4), VAV1(7), VAV2(8), VAV3(6), XPO5(1) 17985403 276 71 274 104 77 94 8 61 36 0 0.41 1.00 1.00 331 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(3), CD14(1), CD19(1), CD1A(1), CD1B(3), CD1C(2), CD1D(5), CD1E(5), CD2(2), CD22(1), CD33(2), CD34(2), CD36(2), CD37(1), CD38(2), CD3E(3), CD3G(2), CD4(3), CD44(5), CD5(5), CD55(1), CD59(1), CD7(4), CD8A(2), CD8B(1), CR1(17), CR2(4), CSF1R(7), CSF2RA(6), CSF3(1), CSF3R(6), EPOR(2), FCER2(2), FLT3(7), GP5(2), GYPA(1), HLA-DRA(3), HLA-DRB1(1), IL11(2), IL11RA(2), IL1B(1), IL1R1(3), IL1R2(1), IL2RA(1), IL3(1), IL3RA(4), IL4R(1), IL5RA(1), IL6(1), IL7R(3), ITGA1(4), ITGA2(4), ITGA2B(5), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGAM(5), ITGB3(5), KIT(6), KITLG(3), MME(5), TFRC(1), THPO(2), TNF(2), TPO(13) 16158087 217 71 214 89 62 65 9 53 26 2 0.67 1.00 1.00 332 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(2), IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(3), INPP5B(2), INPP5E(2), INPPL1(13), IPMK(1), ISYNA1(2), ITGB1BP3(3), ITPK1(2), ITPKA(1), ITPKB(6), MINPP1(3), MIOX(1), OCRL(4), PI4KA(10), PI4KB(4), PIK3C3(8), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1C(6), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLCD1(1), PLCD3(6), PLCE1(9), PLCG1(10), PLCG2(6), PLCZ1(2), PTEN(8), PTPMT1(1), SYNJ1(7), SYNJ2(15) 14671842 248 70 228 68 77 92 5 47 26 1 0.0037 1.00 1.00 333 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(2), AKT2(2), AKT3(3), BTK(2), FCER1A(1), FYN(5), GRB2(1), IL13(2), IL3(1), INPP5D(1), KRAS(17), LCP2(7), LYN(4), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(13), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), MAPK9(3), NRAS(1), PDK1(1), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCG1(10), PLCG2(6), PRKCD(3), PRKCE(6), RAC2(1), RAC3(1), RAF1(6), SOS1(4), SOS2(5), SYK(3), TNF(2), VAV1(7), VAV2(8), VAV3(6) 14261301 256 70 231 79 68 107 6 55 20 0 0.026 1.00 1.00 334 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(8), AMY2A(2), AMY2B(4), ASCC3(20), ATP13A2(7), DDX18(8), DDX19A(3), DDX23(6), DDX4(2), DDX41(7), DDX47(2), DDX50(3), DDX51(4), DDX54(6), DDX55(3), DDX56(4), DHX58(4), ENPP1(1), ENPP3(3), ENTPD7(8), EP400(19), ERCC2(4), ERCC3(3), GAA(2), GANC(4), GBA(4), GBA3(1), GBE1(4), GCK(3), GPI(4), GUSB(3), GYS1(4), GYS2(2), HK1(6), HK2(6), HK3(3), IFIH1(4), LYZL1(2), MGAM(7), MOV10L1(4), NUDT5(1), NUDT8(1), PGM1(3), PGM3(6), PYGB(4), PYGL(5), PYGM(7), RAD54B(3), RAD54L(4), RUVBL2(3), SETX(11), SI(11), SKIV2L2(3), SMARCA2(17), SMARCA5(1), TREH(4), UGDH(4), UGP2(1), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), UXS1(3) 24366227 310 69 308 114 101 106 12 52 39 0 0.36 1.00 1.00 335 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(6), ABCA10(9), ABCA12(21), ABCA13(27), ABCA2(6), ABCA3(12), ABCA4(10), ABCA5(7), ABCA6(4), ABCA7(6), ABCA8(7), ABCA9(9), ABCB1(10), ABCB10(7), ABCB11(6), ABCB4(13), ABCB5(6), ABCB6(4), ABCB7(1), ABCB8(4), ABCB9(2), ABCC1(4), ABCC10(4), ABCC11(10), ABCC12(8), ABCC2(12), ABCC3(6), ABCC4(6), ABCC5(11), ABCC6(6), ABCC8(8), ABCC9(20), ABCD1(3), ABCD2(4), ABCD3(3), ABCD4(5), ABCG1(3), ABCG2(3), ABCG4(3), ABCG5(1), ABCG8(4), CFTR(3), TAP1(3), TAP2(7) 23485351 314 69 309 116 95 106 12 64 37 0 0.19 1.00 1.00 336 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(2), AKT2(2), AKT3(3), BCL10(1), BLNK(2), BTK(2), CARD11(12), CD19(1), CD22(1), CD72(1), CD79A(6), CD81(3), CR2(4), FCGR2B(1), GSK3B(2), IFITM1(1), IKBKB(3), INPP5D(1), JUN(2), KRAS(17), LILRB3(2), LYN(4), MALT1(5), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NFKB1(5), NFKB2(3), NFKBIB(4), NRAS(1), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLCG2(6), PPP3CA(3), PPP3CB(1), PPP3R2(1), PTPN6(3), RAC2(1), RAC3(1), RASGRP3(2), SYK(3), VAV1(7), VAV2(8), VAV3(6) 14750718 244 68 218 86 68 102 6 44 24 0 0.12 1.00 1.00 337 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(20), AXIN1(7), CCND1(1), CCND2(1), CCND3(2), CSNK1E(6), CTNNB1(11), DVL1(4), DVL2(3), DVL3(5), FBXW2(2), FZD1(8), FZD10(8), FZD2(3), FZD3(4), FZD5(1), FZD6(8), FZD7(2), FZD8(4), GSK3B(2), JUN(2), LDLR(4), MAPK10(3), MAPK9(3), PAFAH1B1(3), PLAU(2), PPP2R5C(1), PPP2R5E(4), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCI(6), PRKCQ(2), PRKD1(6), RHOA(8), SFRP4(2), TCF7(2), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(5), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2) 11801751 203 68 195 83 68 44 8 50 30 3 0.58 1.00 1.00 338 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(2), ACTB(4), ACTG1(2), ARHGEF2(5), CD14(1), CDC42(1), CDH1(14), CLDN1(1), CTNNB1(11), CTTN(2), FYN(5), HCLS1(1), ITGB1(4), KRT18(3), LY96(1), NCK1(3), NCK2(2), NCL(7), OCLN(1), RHOA(8), ROCK1(7), ROCK2(3), TLR4(13), TLR5(4), TUBA1B(1), TUBA1C(2), TUBA3C(6), TUBA3D(5), TUBA3E(5), TUBA8(3), TUBAL3(3), TUBB1(4), TUBB2A(2), TUBB2C(2), TUBB3(8), TUBB4(1), TUBB4Q(2), TUBB6(5), TUBB8(2), WASL(1), YWHAQ(2), YWHAZ(1) 10418350 160 67 151 64 44 52 7 44 13 0 0.60 1.00 1.00 339 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(2), ACTB(4), ACTG1(2), ARHGEF2(5), CD14(1), CDC42(1), CDH1(14), CLDN1(1), CTNNB1(11), CTTN(2), FYN(5), HCLS1(1), ITGB1(4), KRT18(3), LY96(1), NCK1(3), NCK2(2), NCL(7), OCLN(1), RHOA(8), ROCK1(7), ROCK2(3), TLR4(13), TLR5(4), TUBA1B(1), TUBA1C(2), TUBA3C(6), TUBA3D(5), TUBA3E(5), TUBA8(3), TUBAL3(3), TUBB1(4), TUBB2A(2), TUBB2C(2), TUBB3(8), TUBB4(1), TUBB4Q(2), TUBB6(5), TUBB8(2), WASL(1), YWHAQ(2), YWHAZ(1) 10418350 160 67 151 64 44 52 7 44 13 0 0.60 1.00 1.00 340 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(2), AKT1(2), AKT2(2), AKT3(3), ANGPTL2(4), ARHGAP4(2), ARHGEF11(12), BTK(2), CDC42(1), CFL1(1), GDI1(1), INPPL1(13), ITPR1(17), ITPR2(18), ITPR3(16), LIMK1(4), MYLK(9), MYLK2(3), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PDK1(1), PIK3CA(33), PIK3CD(8), PIK3CG(10), PIK3R1(7), PITX2(2), PPP1R13B(6), PTEN(8), RACGAP1(2), RHO(2), ROCK1(7), ROCK2(3), SAG(1), WASF1(4), WASL(1) 13960035 227 67 211 72 77 76 14 35 25 0 0.041 1.00 1.00 341 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(2), CCKBR(4), CCR2(3), CCR3(4), CCR5(1), CELSR1(14), CELSR2(18), CELSR3(15), CHRM2(7), CHRM3(6), CIDEB(1), DRD4(1), EDNRA(3), EMR2(3), EMR3(4), F2R(2), FSHR(17), GNRHR(3), GPR116(14), GPR132(1), GPR133(8), GPR135(6), GPR143(1), GPR17(1), GPR55(5), GPR56(1), GPR61(3), GPR84(1), GRM1(17), GRPR(3), HRH4(1), LGR6(4), LPHN2(11), LPHN3(11), LTB4R2(3), NTSR1(4), OR2M4(1), OR8G2(5), P2RY13(4), PTGFR(3), SMO(6), SSTR2(2), TAAR5(3), TSHR(8), VN1R1(3) 13068214 238 66 234 68 70 73 10 69 16 0 0.0074 1.00 1.00 342 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(5), CPEB1(2), EGFR(10), ERBB2(6), ERBB4(18), ETS1(4), ETS2(1), ETV6(3), ETV7(1), FMN2(15), GRB2(1), KRAS(17), MAP2K1(4), MAPK1(2), MAPK3(1), NOTCH1(15), NOTCH2(16), NOTCH3(10), NOTCH4(7), PIWIL1(6), PIWIL2(7), PIWIL3(2), PIWIL4(2), RAF1(6), SOS1(4), SOS2(5), SPIRE1(2), SPIRE2(2) 10250243 174 66 159 68 50 55 7 43 19 0 0.61 1.00 1.00 343 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(2), AKT2(2), AKT3(3), BAD(1), CASP9(1), CDC42(1), KDR(7), KRAS(17), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK3(3), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NOS3(3), NRAS(1), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCG1(10), PLCG2(6), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKCG(4), PTGS2(2), PTK2(7), PXN(2), RAC2(1), RAC3(1), RAF1(6), SH2D2A(2), SHC2(2), SPHK1(5) 14177482 237 66 211 74 66 97 11 43 20 0 0.017 1.00 1.00 344 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(2), BDKRB2(3), CALM1(1), CALM2(2), CALM3(1), CAV1(2), CHRM1(3), CHRNA1(3), FLT1(6), FLT4(8), KDR(7), NOS3(3), PDE2A(6), PDE3A(8), PDE3B(10), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKG1(6), PRKG2(6), RYR2(43), SLC7A1(2) 8100208 138 65 138 54 37 51 5 39 6 0 0.37 1.00 1.00 345 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(2), APOA1(2), CD36(2), CITED2(1), CPT1B(4), CREBBP(13), DUSP1(1), DUT(1), EHHADH(2), EP300(15), HSD17B4(2), HSPA1A(1), JUN(2), LPL(2), MAPK1(2), MAPK3(1), ME1(3), NCOA1(11), NCOR1(14), NCOR2(15), NR0B2(2), NR1H3(2), NR2F1(4), NRIP1(7), PDGFA(1), PIK3CA(33), PIK3R1(7), PPARA(3), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PTGS2(2), RB1(8), RELA(2), RXRA(3), SP1(3), SRA1(1), STAT5A(1), STAT5B(4), TNF(2) 12490727 196 65 181 56 39 77 9 42 29 0 0.019 1.00 1.00 346 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(2), AKT2(2), AKT3(3), BAD(1), BCL2(1), BCR(7), BLNK(2), BTK(2), CD19(1), CD22(1), CD81(3), CR2(4), CSK(3), DAG1(7), FLOT1(1), FLOT2(3), GRB2(1), GSK3A(1), GSK3B(2), INPP5D(1), ITPR1(17), ITPR2(18), ITPR3(16), LYN(4), MAP4K1(2), MAPK1(2), MAPK3(1), NFATC1(9), NFATC2(8), NR0B2(2), PDK1(1), PIK3CA(33), PIK3CD(8), PIK3R1(7), PLCG2(6), PPP1R13B(6), PPP3CA(3), PPP3CB(1), PTPRC(16), RAF1(6), SHC1(3), SOS1(4), SOS2(5), SYK(3), VAV1(7) 14708142 236 65 219 77 70 86 9 44 27 0 0.058 1.00 1.00 347 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(2), AKT2(2), AKT3(3), BRD4(5), CAP1(2), CBL(2), CDC42(1), CDKN2A(4), F2RL2(1), FLOT1(1), FLOT2(3), GRB2(1), GSK3A(1), GSK3B(2), IGFBP1(2), INPPL1(13), IRS1(7), IRS2(3), IRS4(11), LNPEP(9), MAPK1(2), MAPK3(1), PARD3(8), PDK1(1), PIK3CA(33), PIK3CD(8), PIK3R1(7), PPYR1(7), PTEN(8), RAF1(6), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KB1(3), SERPINB6(3), SHC1(3), SLC2A4(1), SORBS1(7), SOS1(4), SOS2(5), YWHAG(1), YWHAH(1), YWHAQ(2), YWHAZ(1) 11726772 201 65 184 63 71 74 5 28 23 0 0.044 1.00 1.00 348 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(2), AKT2(2), AKT3(3), BCR(7), BTK(2), CD19(1), CDKN2A(4), DAPP1(1), FLOT1(1), FLOT2(3), GAB1(1), ITPR1(17), ITPR2(18), ITPR3(16), LYN(4), NR0B2(2), PDK1(1), PHF11(2), PIK3CA(33), PITX2(2), PLCG2(6), PPP1R13B(6), PREX1(9), PTEN(8), PTPRC(16), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KB1(3), SAG(1), SYK(3), TEC(3), VAV1(7) 11020093 198 65 183 67 61 66 9 41 21 0 0.15 1.00 1.00 349 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), AK3(4), CAD(7), CANT1(4), CDA(2), CTPS(2), CTPS2(2), DCK(1), DCTD(1), DHODH(1), DPYD(13), DPYS(2), DTYMK(1), DUT(1), ENTPD1(3), ENTPD3(3), ENTPD4(6), ENTPD6(1), ENTPD8(4), NME6(3), NME7(1), NT5C(1), NT5C1A(1), NT5C1B(4), NT5C2(5), NUDT2(2), PNPT1(3), POLA1(4), POLA2(2), POLD1(7), POLD3(2), POLE(14), POLE2(2), POLE3(1), POLE4(1), POLR1A(8), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(6), POLR3G(1), POLR3K(1), PRIM1(1), PRIM2(3), RRM1(4), RRM2(2), RRM2B(2), TK1(2), TK2(3), TXNRD1(5), TXNRD2(3), TYMS(1), UCK1(2), UCK2(1), UMPS(1), UPB1(2), UPP1(1), UPP2(5), UPRT(1) 16087881 201 64 201 70 64 64 10 39 24 0 0.19 1.00 1.00 350 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(1), AGT(2), AKT1(2), CALM1(1), CALM2(2), CALM3(1), CALR(4), CAMK1(1), CAMK1G(3), CAMK4(4), CREBBP(13), EDN1(3), ELSPBP1(1), F2(4), FGF2(2), GATA4(3), GSK3B(2), HAND1(3), HAND2(3), IGF1(2), LIF(2), MAP2K1(4), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(4), MEF2C(2), MYH2(14), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NKX2-5(2), NPPA(1), PIK3CA(33), PIK3R1(7), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RAF1(6), RPS6KB1(3) 9997336 189 64 175 61 48 75 10 33 23 0 0.053 1.00 1.00 351 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(2), APC(20), AR(8), ASAH1(2), BRAF(5), CAMP(1), CCL15(1), DAG1(7), EGFR(10), GNA11(4), GNA15(2), GNAI1(1), GNAQ(1), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), KCNJ3(6), KCNJ5(2), MAPK1(2), MAPK10(3), MAPK14(1), PHKA2(7), PIK3CA(33), PIK3CD(8), PIK3R1(7), PITX2(2), PTX3(1), RAF1(6) 10597552 200 63 184 65 59 64 14 40 21 2 0.086 1.00 1.00 352 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), AKT1(2), ANGPTL2(4), DAG1(7), DGKA(3), ETFA(1), GCA(3), ITGA9(9), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), MAP2K1(4), MAPK1(2), MAPK3(1), NR1I3(3), PAK1(4), PDE3A(8), PDE3B(10), PI3(2), PIK3C2G(3), PIK3CA(33), PIK3CD(8), PIK3R1(7), RIPK3(2), SGCB(2), VASP(3) 9723880 181 63 166 49 50 64 13 33 20 1 0.0073 1.00 1.00 353 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(6), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH3A1(5), ALDH3B2(4), AOC2(4), AOC3(3), AOX1(3), CARM1(2), COMT(3), DBH(2), DCT(7), DDC(3), ESCO2(2), FAH(2), GOT1(2), GOT2(3), GSTZ1(3), HGD(2), HPD(1), LCMT1(1), LCMT2(7), MAOA(1), MAOB(3), METTL6(1), MYST3(11), MYST4(15), NAT6(2), PNMT(3), PNPLA3(2), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), SH3GLB1(1), TAT(1), TH(1), TPO(13), TYR(5), TYRP1(5), WBSCR22(2) 11774058 174 62 173 50 49 49 5 48 21 2 0.047 1.00 1.00 354 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 BRAF(5), CREB1(4), DAXX(3), ELK1(2), GRB2(1), IKBKB(3), JUN(2), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K5(1), MAP2K6(2), MAP2K7(13), MAP3K1(8), MAP3K10(6), MAP3K11(3), MAP3K12(4), MAP3K13(5), MAP3K14(3), MAP3K2(2), MAP3K3(2), MAP3K4(10), MAP3K5(3), MAP3K6(5), MAP3K7(7), MAP3K8(1), MAP3K9(5), MAP4K1(2), MAP4K2(4), MAP4K3(2), MAP4K4(5), MAP4K5(4), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(4), MAPK6(1), MAPK7(8), MAPK8(4), MAPK9(3), MAPKAPK3(3), MAPKAPK5(2), MAX(1), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), MKNK1(1), NFKB1(5), PAK1(4), PAK2(5), RAF1(6), RELA(2), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA4(2), RPS6KB1(3), RPS6KB2(3), SHC1(3), SP1(3), STAT1(6), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TRAF2(2) 18866138 249 62 247 86 88 73 8 44 36 0 0.21 1.00 1.00 355 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(2), AKT2(2), AKT3(3), BRAF(5), EIF4B(2), EIF4EBP1(1), HIF1A(2), IGF1(2), MAPK1(2), MAPK3(1), PDPK1(1), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PRKAA1(1), PRKAA2(3), RHEB(1), RICTOR(8), RPS6(1), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA6(7), RPS6KB1(3), RPS6KB2(3), TSC1(4), TSC2(4), ULK1(11), ULK2(4), ULK3(2), VEGFC(3) 10507417 167 61 152 62 56 61 9 28 13 0 0.35 1.00 1.00 356 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(1), CRK(1), DOCK1(12), ELK1(2), GAB1(1), GRB2(1), HGF(11), ITGA1(4), ITGB1(4), JUN(2), MAP2K1(4), MAP2K2(1), MAP4K1(2), MAPK1(2), MAPK3(1), MAPK8(4), MET(4), PAK1(4), PIK3CA(33), PIK3R1(7), PTEN(8), PTK2(7), PTK2B(8), PTPN11(4), PXN(2), RAF1(6), RAP1A(2), RAP1B(4), RASA1(10), SOS1(4), STAT3(7) 8802381 163 61 145 52 35 61 8 33 25 1 0.14 1.00 1.00 357 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(5), AR(8), ESR1(5), ESR2(6), HNF4A(5), NR0B1(2), NR1D1(3), NR1D2(4), NR1H2(4), NR1H3(2), NR1I2(3), NR1I3(3), NR2C2(3), NR2E1(1), NR2F1(4), NR2F2(3), NR2F6(2), NR3C1(5), NR4A1(2), NR4A2(6), NR5A1(5), NR5A2(1), PGR(7), PPARA(3), PPARD(5), PPARG(1), RARA(2), RARB(5), ROR1(6), RORA(2), RORC(3), RXRA(3), RXRG(3), THRA(4), THRB(5), VDR(5) 8268927 136 61 135 51 45 31 7 41 12 0 0.46 1.00 1.00 358 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(2), BMP4(6), BMP5(6), BMP6(5), BMP7(2), BMP8A(1), BMP8B(2), BTRC(3), CSNK1A1L(3), CSNK1D(2), CSNK1E(6), CSNK1G1(2), CSNK1G2(2), CSNK1G3(4), DHH(3), FBXW11(5), GLI1(9), GLI2(9), GLI3(16), GSK3B(2), HHIP(6), IHH(2), LRP2(36), PRKACA(1), PRKACB(2), PRKACG(3), PRKX(2), PTCH1(12), PTCH2(4), SMO(6), STK36(9), SUFU(3), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(5), WNT3A(1), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2) 11881399 218 60 215 77 84 58 8 43 25 0 0.21 1.00 1.00 359 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(3), INPPL1(13), ITPKA(1), ITPKB(6), MIOX(1), OCRL(4), PIK3C2A(4), PIK3C2B(12), PIK3C2G(3), PIK3CA(33), PIK3CB(6), PIK3CG(10), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLCD1(1), PLCG1(10), PLCG2(6) 8915991 156 60 140 42 43 63 5 31 13 1 0.026 1.00 1.00 360 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(2), AKT2(2), AKT3(3), BAD(1), BCR(7), BLNK(2), BTK(2), CD19(1), CSK(3), DAG1(7), EPHB2(11), GRB2(1), ITPKA(1), ITPKB(6), LYN(4), MAP2K1(4), MAP2K2(1), MAPK1(2), NFAT5(5), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PI3(2), PIK3CA(33), PIK3CD(8), PIK3R1(7), PLCG2(6), PPP1R13B(6), RAF1(6), SERPINA4(2), SHC1(3), SOS1(4), SOS2(5), SYK(3), VAV1(7) 10423303 175 60 157 49 46 68 5 29 26 1 0.025 1.00 1.00 361 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(3), ADCY4(5), ADCY6(5), ADCY8(12), CACNA1A(11), CACNA1B(14), GNAS(14), GNAT3(2), GNB1(1), GNB3(1), GRM4(5), ITPR3(16), KCNB1(5), PDE1A(3), PLCB2(4), PRKACA(1), PRKACB(2), PRKACG(3), PRKX(2), SCNN1A(2), SCNN1B(5), SCNN1G(4), TAS1R1(5), TAS1R2(3), TAS1R3(5), TAS2R1(2), TAS2R10(2), TAS2R13(2), TAS2R16(3), TAS2R3(2), TAS2R38(3), TAS2R39(3), TAS2R4(2), TAS2R40(3), TAS2R41(1), TAS2R43(1), TAS2R46(1), TAS2R50(1), TAS2R60(3), TAS2R7(2), TAS2R8(1), TAS2R9(2), TRPM5(2) 11246597 169 59 167 79 57 57 7 38 10 0 0.85 1.00 1.00 362 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CD2BP2(2), CDC40(6), CLK2(6), CLK3(5), CLK4(3), COL2A1(8), CPSF1(11), CPSF2(2), CPSF3(2), CPSF4(2), CSTF1(4), CSTF2(4), CSTF2T(2), CSTF3(4), DDIT3(3), DDX1(3), DDX20(3), DHX15(8), DHX16(5), DHX38(7), DHX8(5), DHX9(1), DICER1(5), DNAJC8(1), GIPC1(2), METTL3(1), NCBP1(4), NUDT21(1), NXF1(3), PABPN1(2), PAPOLA(2), PHF5A(2), POLR2A(9), PPM1G(3), PRPF3(2), PRPF4(4), PRPF4B(9), PRPF8(10), PSKH1(4), PTBP1(4), PTBP2(1), RBM5(3), RNGTT(1), RNMT(3), RNPS1(1), SF3A1(2), SF3A2(1), SF3A3(2), SF3B1(4), SF3B2(6), SF3B4(3), SF4(6), SFRS12(3), SFRS14(6), SFRS16(2), SFRS4(3), SFRS5(4), SFRS6(5), SFRS7(2), SFRS8(7), SFRS9(1), SNRPA(5), SNRPA1(2), SNRPB(1), SNRPD1(3), SNRPD2(2), SNRPD3(1), SNRPE(1), SNRPG(1), SNRPN(4), SPOP(2), SRPK1(2), SRPK2(5), SRRM1(3), SUPT5H(7), U2AF1(2), U2AF2(3), XRN2(12) 20867834 286 59 285 92 105 80 18 56 27 0 0.20 1.00 1.00 363 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(2), AKT3(3), ANKRD6(3), APC(20), AXIN1(7), AXIN2(3), CER1(3), CTNNB1(11), DACT1(4), DKK1(5), DKK2(2), DKK3(1), DKK4(2), DVL1(4), GSK3A(1), GSK3B(2), LRP1(23), MVP(4), NKD1(6), NKD2(1), PIN1(1), PSEN1(1), PTPRA(5), SENP2(3), SFRP1(3), TSHB(1), WIF1(2) 7982080 125 59 123 49 42 39 2 25 15 2 0.59 1.00 1.00 364 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(1), ACADL(2), ACADM(1), ACOX1(2), ACOX2(4), ACOX3(5), ACSL1(2), ACSL3(6), ACSL4(3), ACSL5(2), ACSL6(5), ADIPOQ(2), ANGPTL4(2), APOA1(2), APOA5(5), AQP7(2), CD36(2), CPT1A(4), CPT1B(4), CPT1C(4), CPT2(4), CYP27A1(1), CYP4A11(1), CYP4A22(1), CYP7A1(3), CYP8B1(4), DBI(1), EHHADH(2), FABP2(1), FABP3(1), FABP5(2), FABP6(3), FABP7(1), FADS2(4), GK(2), GK2(1), HMGCS2(1), ILK(2), LPL(2), ME1(3), MMP1(2), NR1H3(2), OLR1(2), PCK1(4), PCK2(6), PDPK1(1), PLTP(3), PPARA(3), PPARD(5), PPARG(1), RXRA(3), RXRG(3), SCD(4), SCP2(3), SLC27A1(3), SLC27A2(2), SLC27A4(3), SLC27A5(6), SLC27A6(4), SORBS1(7), UBC(3) 12968549 170 58 170 47 62 40 11 41 16 0 0.015 1.00 1.00 365 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(4), ADAM17(3), ATP6AP1(4), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), CASP3(1), CCL5(1), CDC42(1), CSK(3), EGFR(10), GIT1(2), IGSF5(2), IKBKB(3), IL8(1), JAM3(3), JUN(2), LYN(4), MAP2K4(5), MAP3K14(3), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK8(4), MAPK9(3), MET(4), NFKB1(5), NFKB2(3), NOD1(7), PAK1(4), PLCG1(10), PLCG2(6), PTPN11(4), PTPRZ1(15), RELA(2), TCIRG1(4), TJP1(6) 13905064 173 58 172 77 43 57 6 47 20 0 0.88 1.00 1.00 366 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(2), ASAH1(2), BRAF(5), CAMP(1), CREB1(4), CREB3(3), CREB5(2), CREBBP(13), DAG1(7), EGR1(3), EGR2(3), EGR3(1), EGR4(4), ELK1(2), FRS2(4), GNAQ(1), JUN(2), MAP1B(9), MAP2K4(5), MAP2K7(13), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3), NTRK1(4), OPN1LW(4), PIK3C2G(3), PIK3CA(33), PIK3CD(8), PIK3R1(7), PTPN11(4), RPS6KA3(1), SHC1(3), TERF2IP(3), TH(1) 10136109 181 58 166 64 56 63 5 32 25 0 0.20 1.00 1.00 367 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(13), ACSL1(2), ACSL3(6), ACSL4(3), ACSL5(2), ACSL6(5), ADIPOQ(2), ADIPOR1(2), ADIPOR2(2), AGRP(1), AKT1(2), AKT2(2), AKT3(3), CAMKK1(4), CAMKK2(1), CD36(2), CPT1A(4), CPT1B(4), CPT1C(4), CPT2(4), IKBKB(3), IRS1(7), IRS2(3), IRS4(11), JAK1(4), JAK2(8), JAK3(3), LEPR(8), MAPK10(3), MAPK8(4), MAPK9(3), NFKB1(5), NFKB2(3), NFKBIB(4), NPY(1), PCK1(4), PCK2(6), POMC(5), PPARA(3), PPARGC1A(6), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2), PRKAG3(3), PRKCQ(2), PTPN11(4), RELA(2), RXRA(3), RXRG(3), SLC2A1(3), SLC2A4(1), SOCS3(3), STAT3(7), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF2(2), TYK2(6) 16348424 217 57 217 88 73 55 6 55 27 1 0.68 1.00 1.00 368 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(4), CAD(7), CANT1(4), CDA(2), CTPS(2), CTPS2(2), DCK(1), DCTD(1), DHODH(1), DPYD(13), DPYS(2), DTYMK(1), DUT(1), ENTPD1(3), NT5C(1), NUDT2(2), POLD1(7), POLE(14), POLG(4), POLL(1), POLQ(14), POLR1B(2), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(9), RRM1(4), RRM2(2), TK1(2), TK2(3), TXNRD1(5), TYMS(1), UCK1(2), UCK2(1), UMPS(1), UNG(1), UPB1(2), UPP1(1) 11319087 140 57 140 59 41 45 7 30 17 0 0.68 1.00 1.00 369 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(4), APC(20), AXIN1(7), BMP10(2), BMP2(2), BMP4(6), BMP5(6), BMP7(2), BMPR1A(1), BMPR2(10), CHRD(1), CTNNB1(11), DVL1(4), FZD1(8), GATA4(3), GSK3B(2), MAP3K7(7), MEF2C(2), MYL2(1), NKX2-5(2), NPPA(1), NPPB(1), RFC1(1), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6), TGFBR3(2), WNT1(3) 7170285 130 56 126 45 35 33 5 34 19 4 0.55 1.00 1.00 370 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(17), BMPR1B(3), CCND2(1), DMC1(1), EGR1(3), ESR2(6), FSHR(17), GJA4(4), INHA(2), LHCGR(7), MLH1(3), MSH5(5), NCOR1(14), NR5A1(5), NRIP1(7), PGR(7), PRLR(2), PTGER2(2), SMPD1(4), VDR(5), ZP2(5) 6924628 120 56 116 35 33 42 5 26 13 1 0.083 1.00 1.00 371 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(20), AXIN1(7), CREBBP(13), CTNNB1(11), DVL1(4), EP300(15), FZD1(8), GSK3B(2), HDAC1(2), LDB1(5), LEF1(4), PITX2(2), TRRAP(27), WNT1(3) 6530618 123 56 121 51 43 27 3 24 24 2 0.77 1.00 1.00 372 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CDK5(2), CDK5R1(1), CFL1(1), CHN1(4), LIMK1(4), MAP3K1(8), MYL2(1), MYLK(9), NCF2(1), PAK1(4), PDGFRA(4), PIK3CA(33), PIK3R1(7), PLD1(7), PPP1R12B(7), RALBP1(7), RPS6KB1(3), TRIO(22), VAV1(7), WASF1(4) 6929746 136 56 121 49 40 52 5 24 14 1 0.36 1.00 1.00 373 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(2), AKT3(3), ASAH1(2), BRAF(5), DAG1(7), DRD2(6), EGFR(10), EPHB2(11), GRB2(1), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), KCNJ3(6), KCNJ5(2), MAPK1(2), PI3(2), PIK3CB(6), PITX2(2), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), RAF1(6), RGS20(2), SHC1(3), SOS1(4), SOS2(5), STAT3(7), TERF2IP(3) 11634546 189 56 186 70 63 61 6 36 22 1 0.38 1.00 1.00 374 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(2), AKT2(2), AKT3(3), BAD(1), BTK(2), CDKN2A(4), DAPP1(1), GRB2(1), GSK3A(1), GSK3B(2), IARS(7), IGFBP1(2), INPP5D(1), PDK1(1), PIK3CA(33), PPP1R13B(6), PTEN(8), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KB1(3), SHC1(3), SOS1(4), SOS2(5), TEC(3), YWHAG(1), YWHAH(1), YWHAQ(2), YWHAZ(1) 7139564 115 56 101 37 26 51 3 22 13 0 0.18 1.00 1.00 375 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), AGK(2), AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPAT6(2), AKR1B1(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), CEL(6), DAK(3), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKI(5), DGKQ(2), DGKZ(1), GK(2), GK2(1), GLB1(3), GPAM(5), LCT(11), LIPA(2), LIPC(2), LIPF(1), LIPG(3), LPL(2), PNLIP(2), PNLIPRP1(3), PNLIPRP2(2), PNPLA3(2), PPAP2C(5) 11648621 149 55 148 55 37 56 3 35 18 0 0.27 1.00 1.00 376 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(4), ALPL(3), ALPP(5), ALPPL2(4), ASCC3(20), ATP13A2(7), DDX18(8), DDX19A(3), DDX23(6), DDX4(2), DDX41(7), DDX47(2), DDX50(3), DDX51(4), DDX54(6), DDX55(3), DDX56(4), DHX58(4), ENTPD7(8), EP400(19), ERCC2(4), ERCC3(3), FPGS(1), GGH(1), IFIH1(4), MOV10L1(4), NUDT5(1), NUDT8(1), QDPR(3), RAD54B(3), RAD54L(4), RUVBL2(3), SETX(11), SKIV2L2(3), SMARCA2(17), SMARCA5(1), SPR(2) 12409047 188 55 185 69 74 53 7 32 22 0 0.43 1.00 1.00 377 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(1), GORASP1(2), MAP2K4(5), MAP2K7(13), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3), MAPKAPK5(2), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PIK3CA(33), PIK3CD(8), PIK3R1(7), TRAF2(2), TRAF3(2), TRAF6(4) 6595701 124 55 109 33 40 44 6 19 15 0 0.014 1.00 1.00 378 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(2), APAF1(2), BAG4(2), BCL2(1), BID(1), BIRC2(2), BIRC3(4), CASP2(3), CASP3(1), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), DAXX(3), DFFA(2), DFFB(2), GSN(5), LMNA(5), LMNB1(2), LMNB2(3), MAP2K7(13), MAP3K1(8), MAP3K14(3), MAP3K5(3), MAPK8(4), MDM2(3), NFKB1(5), NUMA1(14), PAK2(5), PRKCD(3), PRKDC(22), PSEN1(1), PSEN2(2), PTK2(7), RASA1(10), RB1(8), RELA(2), SPTAN1(13), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF1(2), TRAF2(2) 13784703 187 54 184 59 57 58 9 33 29 1 0.10 1.00 1.00 379 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(4), AASS(2), ACAT1(3), ACAT2(3), AKR1B10(1), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), BBOX1(1), DLST(1), DOT1L(9), EHHADH(2), EHMT1(7), EHMT2(4), GCDH(3), HADH(2), HADHA(2), HSD17B4(2), HSD3B7(3), NSD1(13), OGDH(8), OGDHL(3), PIPOX(3), PLOD1(6), PLOD2(3), PLOD3(4), RDH11(1), RDH12(1), SETD1A(7), SETDB1(12), SHMT1(1), SHMT2(4), SPCS3(1), SUV39H1(4), SUV39H2(1), TMLHE(4) 11447372 149 54 146 56 46 49 6 27 21 0 0.37 1.00 1.00 380 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(3), AKT1(2), APC(20), ASAH1(2), CAMP(1), DAG1(7), DLG4(5), EPHB2(11), GNAI1(1), GNAQ(1), ITPR1(17), ITPR2(18), ITPR3(16), KCNJ3(6), KCNJ5(2), MAPK1(2), PITX2(2), PTX3(1), RHO(2), RYR1(33) 9135416 152 54 148 62 63 33 8 27 20 1 0.56 1.00 1.00 381 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(2), CSK(3), CTLA4(3), DAG1(7), DTYMK(1), EPHB2(11), FBXW7(11), GRAP2(1), GRB2(1), ITK(4), ITPKA(1), ITPKB(6), LCK(1), LCP2(7), MAPK1(2), NCK1(3), NFAT5(5), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PLCG1(10), PTPRC(16), RAF1(6), RASGRP1(4), RASGRP2(4), RASGRP3(2), RASGRP4(3), SOS1(4), SOS2(5), VAV1(7), ZAP70(4) 11069594 172 54 165 63 48 46 5 43 29 1 0.57 1.00 1.00 382 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(6), AGMAT(2), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH4A1(2), ALDH9A1(4), AMD1(2), AOC2(4), AOC3(3), ARG1(2), ASL(5), CKB(1), CKMT1A(2), CKMT1B(3), CKMT2(6), CPS1(15), DAO(5), GATM(2), GLUD1(4), GOT1(2), GOT2(3), MAOA(1), MAOB(3), NOS1(16), NOS3(3), ODC1(3), OTC(2), P4HA1(1), P4HA2(6), P4HA3(1), P4HB(4), PYCR1(2), RARS(2), SMS(2) 8734139 147 53 146 41 51 39 5 37 14 1 0.038 1.00 1.00 383 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(11), AKT1(2), ASAH1(2), GNAI1(1), GNB1(1), GNGT1(3), ITGAV(4), ITGB3(5), MAPK1(2), MAPK3(1), PDGFA(1), PDGFRA(4), PIK3CA(33), PIK3R1(7), PLCB1(12), PTK2(7), SMPD1(4), SPHK1(5) 5427976 105 53 91 37 28 46 8 11 12 0 0.21 1.00 1.00 384 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(4), B3GALNT1(2), B3GALT1(2), B3GALT2(5), B3GALT4(3), B3GALT5(1), B3GNT1(1), B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(1), B4GALNT1(2), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), B4GALT6(2), FUT1(2), FUT4(1), FUT7(1), FUT9(3), GCNT2(2), PIGA(2), PIGB(4), PIGC(2), PIGG(5), PIGK(1), PIGL(1), PIGM(4), PIGN(3), PIGO(1), PIGQ(2), PIGS(1), PIGT(3), PIGV(3), PIGX(2), PIGZ(2), ST3GAL1(3), ST3GAL2(4), ST3GAL3(2), ST3GAL4(3), ST3GAL5(1), ST3GAL6(2), ST6GALNAC3(3), ST6GALNAC4(2), ST6GALNAC5(1), ST6GALNAC6(3), ST8SIA1(4), ST8SIA5(2) 9591689 114 53 113 45 40 33 5 29 6 1 0.49 1.00 1.00 385 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(6), DIAPH1(4), FYN(5), GSN(5), ITGA1(4), ITGB1(4), MAP2K1(4), MAPK1(2), MAPK3(1), MYL2(1), MYLK(9), PIK3CA(33), PIK3R1(7), PTK2(7), PXN(2), RAF1(6), ROCK1(7), SHC1(3), TLN1(13) 7407037 123 52 108 33 27 50 8 22 15 1 0.032 1.00 1.00 386 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(6), AGXT(1), AGXT2(6), ALAS1(2), ALAS2(4), AMT(4), AOC2(4), AOC3(3), BHMT(5), CBS(3), CHDH(4), CHKA(1), CHKB(3), CPT1B(4), CTH(2), DAO(5), DLD(2), DMGDH(5), GARS(1), GATM(2), GCAT(3), GLDC(5), MAOA(1), MAOB(3), PEMT(1), PISD(4), PLCB2(4), PLCG1(10), PLCG2(6), PSPH(2), SARDH(4), SARS(4), SHMT1(1), SHMT2(4), TARS(6) 8303360 125 52 124 49 37 30 9 35 13 1 0.64 1.00 1.00 387 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(7), AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPAT6(2), CDS1(4), CDS2(1), CHAT(1), CHKA(1), CHKB(3), CHPT1(1), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKI(5), DGKQ(2), DGKZ(1), ESCO2(2), ETNK2(2), GNPAT(1), GPAM(5), GPD1(3), GPD1L(3), GPD2(3), LCAT(1), LYPLA2(1), MYST3(11), MYST4(15), NAT6(2), PCYT1A(7), PCYT1B(3), PEMT(1), PISD(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLD1(7), PLD2(11), PNPLA3(2), PPAP2C(5), PTDSS1(1), PTDSS2(2), SH3GLB1(1) 12927296 172 52 171 65 59 56 8 36 13 0 0.31 1.00 1.00 388 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(2), AKT2(2), AKT3(3), BAD(1), BCL2(1), GRB2(1), GSK3A(1), GSK3B(2), IL4R(1), IRS1(7), IRS2(3), JAK1(4), JAK3(3), MAP4K1(2), MAPK1(2), MAPK3(1), PDK1(1), PIK3CA(33), PIK3CD(8), PIK3R1(7), PPP1R13B(6), RAF1(6), SHC1(3), SOCS1(1), SOS1(4), SOS2(5) 7201323 110 52 94 31 30 48 3 19 9 1 0.051 1.00 1.00 389 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(20), AXIN1(7), BTRC(3), CCND1(1), CREBBP(13), CSNK1D(2), CSNK2A1(4), CTBP1(2), CTNNB1(11), DVL1(4), FZD1(8), GSK3B(2), HDAC1(2), MAP3K7(7), NLK(5), PPARD(5), PPP2CA(3), TLE1(3), WIF1(2), WNT1(3) 5795793 107 52 104 38 32 27 5 19 22 2 0.46 1.00 1.00 390 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), AGPAT1(1), AGPAT3(2), AGPAT4(5), AKR1B1(5), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), CEL(6), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKQ(2), DGKZ(1), GK(2), GLB1(3), LCT(11), LIPC(2), LIPF(1), LIPG(3), LPL(2), PNLIP(2), PNLIPRP1(3), PNLIPRP2(2), PPAP2C(5) 9570515 134 51 133 55 36 47 2 32 17 0 0.53 1.00 1.00 391 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(8), GABBR1(8), GPRC5A(1), GPRC5B(4), GPRC5C(3), GPRC5D(1), GRM1(17), GRM2(11), GRM3(5), GRM4(5), GRM5(14), GRM7(12), GRM8(11) 4137303 100 51 100 36 44 20 5 24 7 0 0.25 1.00 1.00 392 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(3), ACTN2(15), ACTN3(2), BCAR1(4), BCR(7), CAPN1(3), CAPNS1(1), CAPNS2(1), CAV1(2), CSK(3), FYN(5), GRB2(1), ITGA1(4), ITGB1(4), JUN(2), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MAPK8(4), PPP1R12B(7), PTK2(7), PXN(2), RAF1(6), RAP1A(2), ROCK1(7), SHC1(3), SOS1(4), TLN1(13), VCL(2), ZYX(2) 9283378 125 51 123 53 41 38 5 29 12 0 0.71 1.00 1.00 393 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(11), ARHGEF1(2), F2(4), F2R(2), GNA12(1), GNAI1(1), GNAQ(1), GNB1(1), GNGT1(3), MAP3K7(7), PIK3CA(33), PIK3R1(7), PLCB1(12), PPP1R12B(7), PTK2B(8), ROCK1(7) 5107375 107 51 93 37 28 45 4 18 12 0 0.33 1.00 1.00 394 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(23), B3GALT4(3), CDR1(4), DGKI(5), IL6ST(2), PIGK(1), RPL10(2), RPL12(1), RPL13(1), RPL13A(1), RPL14(1), RPL18A(1), RPL19(2), RPL22(10), RPL27A(1), RPL3(2), RPL31(1), RPL34(1), RPL36(1), RPL5(1), RPL6(1), RPL7A(3), RPL8(2), RPL9(2), RPLP0(3), RPLP1(1), RPS10(1), RPS11(1), RPS13(1), RPS14(2), RPS20(1), RPS23(1), RPS27A(1), RPS3(1), RPS3A(1), RPS5(2), RPS6(1), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA6(7), RPS6KB1(3), RPS6KB2(3), RPSA(4), SLC36A2(4), TBC1D10C(1), TSPAN9(1), UBC(3) 10384990 129 51 120 49 28 42 7 31 20 1 0.81 1.00 1.00 395 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(2), AKT2(2), AKT3(3), CISH(2), GRB2(1), IARS(7), IL13RA1(2), IL2RG(3), IL4R(1), INPP5D(1), JAK1(4), JAK2(8), JAK3(3), NR0B2(2), PI3(2), PIK3CA(33), PPP1R13B(6), RPS6KB1(3), SERPINA4(2), SHC1(3), SOS1(4), SOS2(5), TYK2(6) 7303586 105 51 90 32 19 45 4 23 13 1 0.19 1.00 1.00 396 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(6), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH3A1(5), ALDH3B2(4), AOC2(4), AOC3(3), AOX1(3), COMT(3), DBH(2), DCT(7), DDC(3), FAH(2), GOT1(2), GOT2(3), GSTZ1(3), HGD(2), HPD(1), MAOA(1), MAOB(3), PNMT(3), TAT(1), TH(1), TPO(13), TYR(5) 6275275 108 51 107 35 30 29 1 34 12 2 0.25 1.00 1.00 397 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B1(3), EIF2B3(3), EIF2B4(6), EIF2B5(4), EIF2S1(1), EIF2S2(2), EIF2S3(1), ELAVL1(3), FLT1(6), FLT4(8), HIF1A(2), KDR(7), NOS3(3), PIK3CA(33), PIK3R1(7), PLCG1(10), PTK2(7), PXN(2), SHC1(3) 6707419 111 51 95 30 32 45 7 18 9 0 0.025 1.00 1.00 398 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(9), CARM1(2), CCND1(1), CREBBP(13), EP300(15), ERCC3(3), ESR1(5), GRIP1(8), GTF2A1(2), GTF2E1(5), GTF2F1(2), HDAC1(2), HDAC2(4), HDAC3(4), HDAC4(7), HDAC5(4), HDAC6(3), MEF2C(2), NCOR2(15), NR0B1(2), NRIP1(7), PELP1(6), POLR2A(9), SRA1(1), TBP(3) 9068427 134 50 132 46 40 35 6 29 24 0 0.30 1.00 1.00 399 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(11), AKT1(2), CAMK2A(1), CAMK2B(2), CAMK2G(4), CREB1(4), GNAS(14), GRB2(1), MAPK1(2), MAPK14(1), MAPK3(1), PIK3CA(33), PIK3R1(7), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RPS6KA1(6), SOS1(4) 5741073 108 50 93 31 29 50 3 14 12 0 0.089 1.00 1.00 400 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(7), ACSS2(3), ACYP2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH3B2(4), ALDH9A1(4), ALDOB(4), ALDOC(3), BPGM(1), DLAT(6), DLD(2), ENO1(3), ENO2(1), ENO3(3), FBP1(1), FBP2(3), GALM(1), GAPDH(1), GAPDHS(2), GCK(3), GPI(4), HK1(6), HK2(6), HK3(3), LDHAL6B(2), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKL(7), PFKM(3), PFKP(8), PGAM2(2), PGAM4(1), PGK1(1), PGK2(1), PGM1(3), PGM3(6), PKLR(4), PKM2(2), TPI1(2) 11496083 167 50 166 64 51 52 7 41 16 0 0.37 1.00 1.00 401 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(2), AARS2(5), ABAT(4), ACY3(1), ADSL(4), ADSS(3), ADSSL1(7), AGXT(1), AGXT2(6), ASL(5), ASNS(4), ASRGL1(1), ASS1(6), CAD(7), CRAT(3), DARS(2), DDO(2), DLAT(6), DLD(2), GAD1(3), GAD2(4), GOT1(2), GOT2(3), GPT(1), GPT2(3), NARS(3), NARS2(1), PC(6), PDHA1(1), PDHA2(4), PDHB(2) 7476091 104 50 102 39 44 26 2 26 6 0 0.46 1.00 1.00 402 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(4), AANAT(1), ABP1(6), ACAT1(3), ACAT2(3), ACMSD(2), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), AOC2(4), AOC3(3), AOX1(3), ASMT(2), CARM1(2), CAT(4), CYP1A1(3), CYP1A2(3), CYP1B1(2), DDC(3), EHHADH(2), GCDH(3), HADH(2), HADHA(2), HSD17B4(2), INMT(1), KYNU(6), LCMT1(1), LCMT2(7), LNX1(4), MAOA(1), MAOB(3), METTL6(1), NFX1(2), OGDH(8), OGDHL(3), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), TDO2(3), TPH1(1), TPH2(4), WARS(3), WARS2(5), WBSCR22(2) 11978322 152 50 147 48 38 49 8 32 23 2 0.094 1.00 1.00 403 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(13), COL4A2(7), COL4A3(4), COL4A4(7), COL4A5(5), COL4A6(7), F10(3), F11(3), F12(2), F2(4), F2R(2), F5(9), F8(13), F9(4), FGA(5), FGB(3), FGG(2), KLKB1(4), PROC(3), PROS1(6), SERPINC1(2), SERPING1(6) 8833521 114 50 113 40 24 39 4 35 12 0 0.36 1.00 1.00 404 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(11), AKT1(2), BAD(1), BCL2(1), CSF2RB(7), IGF1(2), IGF1R(11), IL3(1), IL3RA(4), KIT(6), KITLG(3), PIK3CA(33), PIK3R1(7), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), YWHAH(1) 4336127 105 49 91 34 25 54 3 16 7 0 0.077 1.00 1.00 405 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(9), ATP4A(5), ATP4B(2), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5G3(1), ATP5J(1), ATP5J2(1), ATP5L(1), ATP6AP1(4), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), COX10(1), COX15(3), COX4I1(4), COX4I2(1), COX6B1(1), COX7A2(2), COX7C(1), LHPP(3), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA3(1), NDUFA6(1), NDUFA8(1), NDUFA9(2), NDUFAB1(1), NDUFB2(1), NDUFB7(1), NDUFB8(1), NDUFB9(1), NDUFC2(2), NDUFS1(5), NDUFS2(2), NDUFS5(1), NDUFS6(1), NDUFS7(1), NDUFS8(3), NDUFV1(1), PPA2(2), SDHA(5), SDHB(4), SDHC(1), TCIRG1(4), UQCRB(1), UQCRC1(2), UQCRC2(2), UQCRFS1(1), UQCRQ(1) 11013913 135 49 135 65 37 50 8 32 8 0 0.92 1.00 1.00 406 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(4), ADC(1), ALDH4A1(2), ALDH5A1(3), CAD(7), CPS1(15), EARS2(2), EPRS(6), GAD1(3), GAD2(4), GCLM(2), GFPT1(3), GFPT2(3), GLS(4), GLS2(5), GLUD1(4), GLUD2(7), GLUL(2), GMPS(3), GOT1(2), GOT2(3), GPT(1), GPT2(3), GSR(4), GSS(1), NADSYN1(5), NAGK(1), PPAT(1), QARS(5) 7823866 106 49 104 38 38 33 6 24 5 0 0.35 1.00 1.00 407 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(6), AGXT(1), AGXT2(6), AKR1B10(1), ALAS1(2), ALAS2(4), AMT(4), AOC2(4), AOC3(3), BHMT(5), CBS(3), CHDH(4), CHKA(1), CHKB(3), CTH(2), DAO(5), DLD(2), DMGDH(5), GARS(1), GATM(2), GCAT(3), GLDC(5), GNMT(2), HSD3B7(3), MAOA(1), MAOB(3), PEMT(1), PHGDH(1), PIPOX(3), PISD(4), PSAT1(2), PSPH(2), RDH11(1), RDH12(1), SARDH(4), SARS(4), SARS2(3), SDS(1), SHMT1(1), SHMT2(4), TARS(6), TARS2(6) 8434837 125 49 125 48 41 29 10 32 12 1 0.54 1.00 1.00 408 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(15), ACACB(13), ACAT1(3), ACAT2(3), ACOT12(4), ACSS1(7), ACSS2(3), ACYP2(1), AKR1B1(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), DLAT(6), DLD(2), GRHPR(2), HAGH(2), LDHAL6B(2), LDHB(2), LDHC(1), LDHD(2), MDH1(3), MDH2(1), ME1(3), ME2(4), ME3(5), PC(6), PCK1(4), PCK2(6), PDHA1(1), PDHA2(4), PDHB(2), PKLR(4), PKM2(2) 9230719 142 49 142 40 44 38 7 35 18 0 0.039 1.00 1.00 409 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(3), CREBBP(13), CTBP1(2), CTBP2(4), DLL1(3), DLL3(2), DLL4(1), DTX1(7), DTX2(2), DTX3L(1), DTX4(4), DVL1(4), DVL2(3), DVL3(5), EP300(15), HDAC1(2), HDAC2(4), JAG1(4), JAG2(1), MAML1(4), MAML2(7), MAML3(7), NCOR2(15), NCSTN(3), NOTCH1(15), NOTCH2(16), NOTCH3(10), NOTCH4(7), NUMB(2), NUMBL(3), PSEN1(1), PSEN2(2), PSENEN(1), PTCRA(1), RBPJ(2), RBPJL(3), RFNG(1) 13532733 180 49 176 81 63 50 7 33 27 0 0.77 1.00 1.00 410 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(1), DAXX(3), EGF(5), EGFR(10), ETS1(4), ETS2(1), HOXA7(2), IKBKB(3), JUN(2), MAP2K1(4), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(13), MAP3K1(8), MAP3K14(3), MAP3K5(3), MAPK1(2), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), NFKB1(5), PPP2CA(3), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCQ(2), RAF1(6), RELA(2), SP1(3), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF2(2) 9707027 126 49 125 50 42 35 2 30 17 0 0.49 1.00 1.00 411 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(8), AMY2A(2), AMY2B(4), ENPP1(1), ENPP3(3), GAA(2), GANAB(3), GBA3(1), GBE1(4), GCK(3), GPI(4), GUSB(3), GYS1(4), GYS2(2), HK1(6), HK2(6), HK3(3), MGAM(7), PGM1(3), PGM3(6), PYGB(4), PYGL(5), PYGM(7), SI(11), UCHL1(2), UCHL3(3), UGDH(4), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2B15(1), UGT2B4(2), UXS1(3) 11343467 122 49 122 43 35 45 4 19 19 0 0.27 1.00 1.00 412 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(2), EIF4A1(2), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4G1(10), EIF4G2(1), EIF4G3(5), GHR(5), IRS1(7), MAPK1(2), MAPK14(1), MAPK3(1), MKNK1(1), PABPC1(3), PDPK1(1), PIK3CA(33), PIK3R1(7), PTEN(8), RPS6KB1(3) 5573230 97 48 83 32 19 44 6 17 11 0 0.30 1.00 1.00 413 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(3), ALOX12(4), ALOX15(2), ALOX5(6), CBR1(1), CBR3(3), CYP4F2(4), CYP4F3(3), EPX(4), GGT1(8), LPO(2), LTA4H(4), MPO(5), PLA2G1B(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PRDX6(1), PTGES2(4), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(2), TPO(13) 5493529 96 48 94 31 35 23 4 25 9 0 0.23 1.00 1.00 414 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(6), AKT1(2), AKT2(2), AKT3(3), DAG1(7), GNAQ(1), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PDK1(1), PHKA2(7), PIK3CB(6), PITX2(2), PLD1(7), PLD2(11), PLD3(5), VN1R1(3) 8914753 139 48 139 50 44 43 9 30 12 1 0.31 1.00 1.00 415 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(5), EEF1B2(1), EEF1D(4), EEF1G(3), EEF2(3), EEF2K(8), EIF1AX(1), EIF1AY(1), EIF2AK1(4), EIF2AK2(2), EIF2AK3(8), EIF2B1(3), EIF2B3(3), EIF2B4(6), EIF2B5(4), EIF2S1(1), EIF2S2(2), EIF2S3(1), EIF4A1(2), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4EBP2(1), EIF4G1(10), EIF4G3(5), EIF5(3), EIF5A(3), EIF5B(6), ETF1(3), GSPT2(1), KIAA0664(9), PABPC1(3), PABPC3(5), PAIP1(1), SLC35A4(4) 8640782 121 48 119 47 42 41 4 26 8 0 0.48 1.00 1.00 416 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(2), BAD(1), BCL2(1), CASP1(2), CASP10(3), CASP2(3), CASP3(1), CASP4(2), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CD40(1), CD40LG(4), CYCS(1), DAXX(3), DFFA(2), DFFB(2), FAS(3), IKBKE(5), LTA(2), NFKB1(5), NGFR(5), NR3C1(5), NTRK1(4), PTPN13(14), SFRS2IP(5), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF1(2), TRAF2(2), TRAF3(2), TRAF6(4) 8656801 102 47 102 43 23 33 8 29 9 0 0.76 1.00 1.00 417 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(3), CASP3(1), CASP6(1), CASP7(2), CASP8(6), DAXX(3), DFFA(2), DFFB(2), FAF1(4), JUN(2), LMNA(5), LMNB1(2), LMNB2(3), MAP2K4(5), MAP3K1(8), MAP3K7(7), MAPK8(4), PAK1(4), PAK2(5), PRKDC(22), PTPN13(14), RB1(8), RIPK2(2), SPTAN1(13) 8240878 128 47 127 38 29 44 5 28 22 0 0.15 1.00 1.00 418 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(6), ALDH1A3(6), ALDH3A1(5), ALDH3B2(4), AOC2(4), AOC3(3), DDC(3), EPX(4), ESCO2(2), GOT1(2), GOT2(3), HPD(1), LPO(2), MAOA(1), MAOB(3), MPO(5), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), PRDX6(1), SH3GLB1(1), TAT(1), TPO(13) 6770098 100 47 100 30 29 26 4 31 9 1 0.18 1.00 1.00 419 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(3), ALOX12(4), ALOX12B(3), ALOX15(2), ALOX15B(1), ALOX5(6), CBR1(1), CBR3(3), CYP2B6(2), CYP2C18(5), CYP2C19(6), CYP2C9(1), CYP2E1(5), CYP2J2(2), CYP2U1(2), CYP4A11(1), CYP4A22(1), CYP4F2(4), CYP4F3(3), DHRS4(1), EPHX2(4), GGT1(8), GPX1(1), GPX3(1), GPX4(3), GPX6(2), GPX7(3), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PTGES2(4), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(2) 7669748 121 47 119 31 43 32 5 31 10 0 0.018 1.00 1.00 420 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), AKR1C1(1), AKR1C3(3), AKR1C4(3), ALDH1A3(6), ALDH3A1(5), ALDH3B2(4), CYP1A1(3), CYP1A2(3), CYP1B1(2), CYP2B6(2), CYP2C18(5), CYP2C19(6), CYP2C9(1), CYP2E1(5), CYP2F1(1), CYP2S1(3), CYP3A4(1), CYP3A43(3), CYP3A5(1), CYP3A7(2), DHDH(5), EPHX1(3), GSTA1(2), GSTA2(1), GSTA4(1), GSTA5(1), GSTM1(1), GSTM3(1), GSTM4(1), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(3), MGST1(2), MGST2(1), MGST3(1), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2) 11152074 135 47 134 47 33 47 2 36 17 0 0.28 1.00 1.00 421 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 BAG4(2), CASP2(3), CASP3(1), CASP8(6), DFFA(2), DFFB(2), JUN(2), LMNA(5), LMNB1(2), LMNB2(3), MADD(6), MAP2K4(5), MAP3K1(8), MAP3K7(7), MAPK8(4), PAK1(4), PAK2(5), PRKDC(22), RB1(8), SPTAN1(13), TNF(2), TNFRSF1A(3), TRAF2(2) 7763758 117 47 116 37 32 38 5 24 18 0 0.17 1.00 1.00 422 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(7), AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPS(3), CDS1(4), CDS2(1), CHAT(1), CHKA(1), CHKB(3), CLC(2), CPT1B(4), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKQ(2), DGKZ(1), GNPAT(1), GPD1(3), GPD2(3), LCAT(1), LYPLA2(1), PAFAH1B1(3), PAFAH2(1), PCYT1A(7), PCYT1B(3), PEMT(1), PISD(4), PLA2G1B(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCB2(4), PLCG1(10), PLCG2(6), PPAP2C(5) 9881640 127 46 125 47 50 39 3 25 10 0 0.28 1.00 1.00 423 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(2), BAD(1), BCL2(1), CBL(2), GRB2(1), IL2RA(1), IL2RG(3), IRS1(7), JAK1(4), JAK3(3), MAPK1(2), MAPK3(1), NMI(1), PIK3CA(33), PIK3R1(7), PTPN6(3), RAF1(6), RPS6KB1(3), SHC1(3), SOCS1(1), SOCS3(3), SOS1(4), STAT5A(1), STAT5B(4), SYK(3) 7137769 100 46 85 36 20 45 3 18 13 1 0.43 1.00 1.00 424 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(7), BLNK(2), ELK1(2), GRB2(1), JUN(2), LYN(4), MAP2K1(4), MAP3K1(8), MAPK1(2), MAPK3(1), MAPK8IP3(9), PAPPA(14), RPS6KA1(6), RPS6KA3(1), SHC1(3), SOS1(4), SYK(3), VAV1(7), VAV2(8), VAV3(6) 6331828 94 46 94 40 28 31 3 19 13 0 0.70 1.00 1.00 425 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(3), ACTN2(15), ACTN3(2), CAPN1(3), CAPNS1(1), CAPNS2(1), ITGA1(4), ITGB1(4), ITGB3(5), PTK2(7), PXN(2), SPTAN1(13), TLN1(13) 5635503 74 46 72 38 31 18 4 15 6 0 0.89 1.00 1.00 426 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(2), AGTR2(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CDK5(2), F2(4), FYN(5), GNA11(4), GNAI1(1), GNB1(1), GNGT1(3), GRB2(1), JAK2(8), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(4), MAPT(4), MYLK(9), PLCG1(10), PTK2B(8), RAF1(6), SHC1(3), SOS1(4), STAT1(6), STAT3(7), STAT5A(1) 8239967 114 45 113 40 36 40 4 23 11 0 0.30 1.00 1.00 427 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(3), F11(3), F12(2), F13B(8), F2(4), F5(9), F7(6), F8(13), F9(4), FGA(5), FGB(3), FGG(2), LPA(11), PLAT(2), PLAU(2), PLG(10), SERPINB2(3), SERPINE1(2), SERPINF2(6), VWF(13) 6987063 111 45 111 33 32 33 5 28 13 0 0.12 1.00 1.00 428 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), ELK1(2), FPR1(1), GNA15(2), GNB1(1), GNGT1(3), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K6(2), MAP3K1(8), MAPK1(2), MAPK14(1), MAPK3(1), NCF1(2), NCF2(1), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NFKB1(5), PAK1(4), PIK3C2G(3), PLCB1(12), PPP3CA(3), PPP3CB(1), RAF1(6), RELA(2) 7583960 107 45 107 35 32 34 2 24 15 0 0.22 1.00 1.00 429 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH3B2(4), ALDH9A1(4), ALDOB(4), ALDOC(3), BPGM(1), DLAT(6), DLD(2), ENO1(3), ENO2(1), ENO3(3), FBP1(1), FBP2(3), GAPDH(1), GCK(3), GPI(4), HK1(6), HK2(6), HK3(3), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKM(3), PFKP(8), PGK1(1), PGM1(3), PGM3(6), PKLR(4), PKM2(2), TPI1(2) 9649021 148 45 147 58 42 45 5 41 15 0 0.51 1.00 1.00 430 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH3B2(4), ALDH9A1(4), ALDOB(4), ALDOC(3), BPGM(1), DLAT(6), DLD(2), ENO1(3), ENO2(1), ENO3(3), FBP1(1), FBP2(3), GAPDH(1), GCK(3), GPI(4), HK1(6), HK2(6), HK3(3), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKM(3), PFKP(8), PGK1(1), PGM1(3), PGM3(6), PKLR(4), PKM2(2), TPI1(2) 9649021 148 45 147 58 42 45 5 41 15 0 0.51 1.00 1.00 431 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(3), C1GALT1(1), C1GALT1C1(4), GALNT1(3), GALNT10(3), GALNT11(5), GALNT12(2), GALNT13(3), GALNT14(6), GALNT2(3), GALNT3(1), GALNT4(1), GALNT5(4), GALNT6(2), GALNT8(5), GALNT9(3), GALNTL1(2), GALNTL2(6), GALNTL4(5), GALNTL5(4), GCNT1(1), GCNT3(2), GCNT4(2), OGT(2), ST3GAL1(3), ST3GAL2(4), ST6GALNAC1(2), WBSCR17(14) 6391037 96 45 93 35 37 30 4 21 4 0 0.43 1.00 1.00 432 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(2), AARS2(5), CARS(4), CARS2(2), DARS(2), EARS2(2), EPRS(6), FARS2(7), FARSA(3), FARSB(1), GARS(1), HARS(4), HARS2(3), IARS(7), IARS2(3), KARS(3), LARS(3), LARS2(5), MARS(3), MARS2(1), NARS(3), NARS2(1), PARS2(1), QARS(5), RARS(2), RARS2(2), SARS(4), SARS2(3), TARS(6), TARS2(6), VARS(8), VARS2(4), WARS(3), WARS2(5), YARS(1), YARS2(1) 10745285 122 45 121 47 42 42 3 29 6 0 0.62 1.00 1.00 433 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(2), CALR(4), CANX(1), CD4(3), CD74(1), CD8A(2), CD8B(1), CIITA(6), CREB1(4), CTSL1(2), CTSS(1), HLA-A(10), HLA-B(12), HLA-C(4), HLA-DMA(2), HLA-DMB(3), HLA-DOA(1), HLA-DPA1(2), HLA-DPB1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(3), HLA-DRB1(1), HLA-E(3), HLA-F(5), HLA-G(2), HSP90AA1(2), HSP90AB1(2), HSPA5(1), IFI30(1), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), KIR2DL1(4), KIR2DL3(1), KIR2DL4(3), KIR2DS4(2), KIR3DL1(2), KLRC1(2), KLRC2(2), KLRD1(2), LGMN(4), LTA(2), PDIA3(1), PSME2(2), RFX5(3), RFXANK(3), TAP1(3), TAP2(7), TAPBP(3) 9192723 143 45 140 46 21 51 14 31 23 3 0.21 1.00 1.00 434 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(2), ACTG2(6), ACTR2(2), AKT1(2), ANGPTL2(4), CDC42(1), CFL1(1), FLNA(11), FLNC(21), FSCN1(5), FSCN3(8), GDI1(1), LIMK1(4), MYH2(14), MYLK(9), MYLK2(3), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PFN2(2), RHO(2), ROCK1(7), ROCK2(3), VASP(3), WASF1(4), WASL(1) 9459217 136 45 136 49 52 43 5 24 12 0 0.14 1.00 1.00 435 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), ELK1(2), IKBKB(3), IRAK1(5), JUN(2), LY96(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP3K1(8), MAP3K14(3), MAP3K7(7), MAPK14(1), MAPK8(4), MYD88(2), NFKB1(5), PPARA(3), RELA(2), TIRAP(2), TLR10(3), TLR2(3), TLR3(2), TLR4(13), TLR6(3), TLR7(3), TLR9(10), TOLLIP(1), TRAF6(4) 7214126 101 45 98 35 29 24 8 28 12 0 0.38 1.00 1.00 436 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(6), ACAT1(3), ACAT2(3), ACMSD(2), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), AOC2(4), AOC3(3), AOX1(3), ASMT(2), CAT(4), CYP19A1(5), CYP1A1(3), CYP1A2(3), CYP2A13(4), CYP2A6(2), CYP2A7(3), CYP2B6(2), CYP2C18(5), CYP2C19(6), CYP2C9(1), CYP2D6(3), CYP2E1(5), CYP2F1(1), CYP2J2(2), CYP3A4(1), CYP3A5(1), CYP3A7(2), CYP4B1(1), CYP4F8(2), CYP51A1(3), DDC(3), EHHADH(2), GCDH(3), HADHA(2), KYNU(6), MAOA(1), MAOB(3), SDS(1), TDO2(3), TPH1(1), WARS(3), WARS2(5) 10898594 151 45 148 49 45 47 5 34 18 2 0.13 1.00 1.00 437 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(4), ALDH4A1(2), ALDH5A1(3), CAD(7), CPS1(15), EPRS(6), GAD1(3), GAD2(4), GCLM(2), GFPT1(3), GLS(4), GLS2(5), GLUD1(4), GLUL(2), GMPS(3), GOT1(2), GOT2(3), GPT(1), GPT2(3), GSS(1), NADSYN1(5), PPAT(1), QARS(5) 6578621 88 44 86 30 31 28 5 19 5 0 0.33 1.00 1.00 438 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), AADAC(2), ABAT(4), ACADS(1), ACAT1(3), ACAT2(3), ACSM1(1), AKR1B10(1), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH5A1(3), ALDH9A1(4), BDH1(1), DDHD1(7), EHHADH(2), GAD1(3), GAD2(4), HADH(2), HADHA(2), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(2), HSD3B7(3), ILVBL(3), L2HGDH(1), OXCT1(4), PDHA1(1), PDHA2(4), PDHB(2), PRDX6(1), RDH11(1), RDH12(1) 8032647 91 44 88 34 30 24 1 27 9 0 0.42 1.00 1.00 439 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(9), ATP4B(2), ATP6AP1(4), ATP6V0A1(4), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), ATP7A(5), ATP7B(12), COX10(1), COX4I1(4), COX6B1(1), COX7A2(2), COX7C(1), NDUFA1(1), NDUFA10(1), NDUFA8(1), NDUFB2(1), NDUFB7(1), NDUFS1(5), NDUFS2(2), NDUFV1(1), PPA2(2), SDHA(5), SDHB(4), SHMT1(1), UQCRB(1), UQCRC1(2), UQCRFS1(1) 7537276 107 44 107 38 28 40 7 23 9 0 0.31 1.00 1.00 440 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(3), APC(20), AXIN1(7), BTRC(3), CTNNB1(11), DLL1(3), DVL1(4), FZD1(8), GSK3B(2), NOTCH1(15), PSEN1(1), WNT1(3) 4179091 80 44 78 35 27 16 2 18 15 2 0.78 1.00 1.00 441 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(2), AKT3(3), ARHGEF11(12), BCL2(1), CDC42(1), DLG4(5), LPA(11), MAP2K4(5), MAP3K1(8), MAP3K5(3), MAPK8(4), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PDK1(1), PHKA2(7), PI3(2), PIK3CB(6), PLD1(7), PLD2(11), PLD3(5), PTK2(7), RDX(2), ROCK1(7), ROCK2(3), SERPINA4(2), SRF(1), TBXA2R(7) 9724990 143 44 143 49 47 46 8 26 16 0 0.23 1.00 1.00 442 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(3), ALG10(5), ALG10B(2), ALG12(1), ALG13(2), ALG2(1), ALG3(2), ALG8(1), ALG9(2), B4GALT1(2), B4GALT2(5), B4GALT3(1), DOLPP1(2), DPM1(1), FUT8(3), GANAB(3), MAN1A2(1), MAN1B1(2), MAN1C1(3), MAN2A1(7), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(1), MGAT5(6), MGAT5B(3), RFT1(2), RPN1(1), RPN2(3), STT3B(5) 8408701 81 43 80 43 21 22 5 20 13 0 0.98 1.00 1.00 443 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(4), ARRB2(3), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CLCA1(3), CLCA2(6), CLCA4(6), CNGA3(6), CNGA4(9), CNGB1(7), GUCA1A(1), GUCA1C(1), PDC(1), PDE1C(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKG1(6), PRKG2(6), PRKX(2) 6056900 84 43 82 33 28 23 4 20 9 0 0.50 1.00 1.00 444 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(2), EIF4A1(2), EIF4A2(3), EIF4B(2), EIF4E(1), EIF4EBP1(1), EIF4G1(10), EIF4G2(1), EIF4G3(5), MKNK1(1), PDPK1(1), PIK3CA(33), PIK3R1(7), PPP2CA(3), PTEN(8), RPS6(1), RPS6KB1(3), TSC1(4), TSC2(4) 5483574 92 43 78 35 21 42 4 15 10 0 0.58 1.00 1.00 445 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(2), CALM1(1), CALM2(2), CALM3(1), CD79A(6), ELK1(2), GRB2(1), JUN(2), LYN(4), MAP2K1(4), MAP3K1(8), MAPK14(1), MAPK3(1), MAPK8(4), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), PLCG1(10), PPP3CA(3), PPP3CB(1), RAF1(6), SHC1(3), SOS1(4), SYK(3), VAV1(7) 7539272 109 42 107 33 37 38 2 20 12 0 0.093 1.00 1.00 446 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDC7(3), CDK2(2), CDT1(2), DIAPH2(3), MCM10(5), MCM2(9), MCM3(4), MCM4(6), MCM5(8), MCM6(1), MCM7(5), NACA(1), ORC1L(10), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(2), POLD1(7), POLD3(2), POLE(14), POLE2(2), PRIM1(1), RFC1(1), RFC2(1), RFC3(4), RFC4(1), RPA1(1), RPA2(1), RPA3(1), RPS27A(1), UBC(3) 10078556 117 42 116 50 39 29 6 22 21 0 0.82 1.00 1.00 447 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(11), CALM1(1), CALM2(2), CALM3(1), CREB1(4), ELK1(2), GNAI1(1), GNAQ(1), GNAS(14), GNB1(1), GNGT1(3), JUN(2), MAP2K1(4), MAPK3(1), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), PLCG1(10), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RAF1(6), RPS6KA3(1) 6873696 115 42 113 37 40 43 1 20 11 0 0.11 1.00 1.00 448 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(15), ACAT1(3), ACAT2(3), ACYP2(1), ADH5(1), AKR1B1(5), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), DLAT(6), DLD(2), GRHPR(2), HAGH(2), LDHB(2), LDHC(1), LDHD(2), MDH1(3), MDH2(1), ME1(3), ME2(4), ME3(5), PC(6), PCK1(4), PDHA1(1), PDHA2(4), PDHB(2), PKLR(4), PKM2(2) 7292657 116 42 116 34 34 35 5 28 14 0 0.079 1.00 1.00 449 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(3), CLOCK(2), CRY1(1), CRY2(2), DAZAP2(3), DNAJA1(2), EIF4G2(1), ETV6(3), G0S2(1), GFRA1(5), GSTM3(1), GSTP1(1), HERPUD1(1), HSPA8(5), KLF9(1), MYF6(2), NCKAP1(6), NR1D2(4), PER1(4), PER2(10), PPP1R3C(3), PPP2CB(3), PSMA4(3), PURA(1), SF3A3(2), SUMO3(1), TOB1(1), TUBB3(8), UCP3(2), UGP2(1), ZFR(7) 7197869 90 41 90 37 28 28 3 26 5 0 0.67 1.00 1.00 450 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(4), AASDH(4), AASS(2), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), BBOX1(1), DLST(1), DOT1L(9), EHHADH(2), EHMT1(7), EHMT2(4), GCDH(3), HADHA(2), PLOD1(6), PLOD2(3), PLOD3(4), SDS(1), SHMT1(1), SHMT2(4), TMLHE(4) 7296757 100 41 99 42 25 36 3 20 16 0 0.55 1.00 1.00 451 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(11), CD3E(3), CD3G(2), CD4(3), CREBBP(13), CSK(3), GNAS(14), GNB1(1), GNGT1(3), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PTPRC(16), ZAP70(4) 4528093 93 40 90 40 24 30 2 20 17 0 0.81 1.00 1.00 452 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(4), CFL1(1), GNAQ(1), GNAS(14), GNB1(1), GNGT1(3), LIMK1(4), MAP2K1(4), MAPK1(2), MAPK3(1), MYL2(1), NOX1(4), PIK3C2G(3), PLCB1(12), PPP1R12B(7), PTK2(7), RAF1(6), ROCK2(3) 5019116 79 40 78 24 28 17 4 17 13 0 0.35 1.00 1.00 453 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(11), CD3E(3), CD3G(2), CD4(3), CREBBP(13), CSK(3), GNAS(14), GNB1(1), GNGT1(3), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PTPRC(16), ZAP70(4) 4528093 93 40 90 40 24 30 2 20 17 0 0.81 1.00 1.00 454 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(10), ELK1(2), GNAS(14), GNB1(1), GNGT1(3), GRB2(1), IGF1R(11), ITGB1(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MKNK1(1), NGFR(5), PDGFRA(4), PPP2CA(3), PTPRR(4), RAF1(6), RPS6KA1(6), SHC1(3), SOS1(4), STAT3(7) 6521941 97 40 95 40 30 33 1 22 11 0 0.69 1.00 1.00 455 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(4), ALDOC(3), DLAT(6), DLD(2), ENO1(3), ENO2(1), ENO3(3), FBP1(1), FBP2(3), GAPDH(1), GAPDHS(2), GCK(3), GOT1(2), GOT2(3), GPI(4), HK1(6), HK2(6), HK3(3), LDHAL6B(2), LDHB(2), LDHC(1), MDH1(3), MDH2(1), PC(6), PCK1(4), PDHA1(1), PDHA2(4), PDHB(2), PDHX(2), PFKL(7), PFKM(3), PFKP(8), PGAM2(2), PGK1(1), PGK2(1), PKLR(4), PKM2(2), TNFAIP1(3), TPI1(2) 8371115 117 40 117 48 50 35 4 22 6 0 0.48 1.00 1.00 456 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(3), AKR1D1(2), ARSD(1), ARSE(3), CARM1(2), CYP11B1(2), CYP11B2(2), CYP19A1(5), HSD11B1(1), HSD11B2(2), HSD17B1(3), HSD17B12(2), HSD17B2(1), HSD17B3(2), HSD17B7(1), HSD3B1(1), HSD3B2(1), LCMT1(1), LCMT2(7), METTL6(1), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), SRD5A1(2), SRD5A2(3), STS(4), SULT1E1(3), SULT2A1(1), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), WBSCR22(2) 9748406 96 40 96 38 25 36 3 18 14 0 0.47 1.00 1.00 457 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(4), ACAA1(1), ACAA2(1), ACADM(1), ACADS(1), ACAT1(3), ACAT2(3), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH6A1(1), ALDH9A1(4), AOX1(3), AUH(5), BCAT1(2), BCAT2(1), BCKDHA(4), DBT(2), DLD(2), EHHADH(2), HADH(2), HADHA(2), HADHB(2), HIBADH(2), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(2), IVD(1), MCCC1(3), MCCC2(2), MCEE(3), MUT(3), OXCT1(4), PCCA(7), PCCB(2) 8523895 98 40 94 34 23 30 1 23 20 1 0.44 1.00 1.00 458 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(9), EXT2(6), EXTL1(4), EXTL2(2), EXTL3(8), GLCE(2), HS2ST1(1), HS3ST1(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), HS3ST5(4), HS6ST1(2), HS6ST2(1), HS6ST3(4), NDST1(8), NDST2(5), NDST3(5), NDST4(10) 4080441 82 40 81 33 27 32 1 16 6 0 0.62 1.00 1.00 459 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ARHGAP4(2), ARHGAP5(6), ARHGAP6(3), ARHGEF1(2), ARHGEF11(12), ARHGEF5(5), ARPC1A(3), ARPC1B(1), ARPC4(1), BAIAP2(3), CFL1(1), DIAPH1(4), GSN(5), LIMK1(4), MYL2(1), MYLK(9), OPHN1(6), PIP5K1A(3), PPP1R12B(7), ROCK1(7), TLN1(13), VCL(2) 8988188 102 40 102 49 38 34 3 17 9 1 0.88 1.00 1.00 460 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(2), CAMK2G(4), DAG1(7), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), NFAT5(5), PDE6A(5), PDE6B(7), PDE6C(2), PDE6G(1), SLC6A13(1), TF(6) 7129506 99 40 99 40 32 31 8 13 14 1 0.49 1.00 1.00 461 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(16), MAP2(18), PPP1CA(2), PPP2CA(3), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAR2A(1), PRKAR2B(6), PRKCE(6) 3610025 59 39 58 23 11 22 0 20 6 0 0.74 1.00 1.00 462 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(2), AGTR1(1), CALM1(1), CALM2(2), CALM3(1), EGFR(10), ELK1(2), GNAQ(1), GRB2(1), JUN(2), MAP2K1(4), MAP2K2(1), MAP2K4(5), MAP3K1(8), MAPK1(2), MAPK3(1), MAPK8(4), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), PAK1(4), PTK2(7), PTK2B(8), RAF1(6), SHC1(3), SOS1(4) 6640676 92 39 92 33 27 27 6 19 13 0 0.35 1.00 1.00 463 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(1), ARSE(3), ASAH1(2), B4GALT6(2), CERK(3), DEGS1(1), DEGS2(2), ENPP7(4), GAL3ST1(4), GALC(5), GBA(4), GLB1(3), LCT(11), NEU1(1), NEU2(2), NEU3(2), NEU4(2), PPAP2C(5), SGMS1(2), SMPD1(4), SMPD3(5), SMPD4(3), SPHK1(5), SPTLC2(3), UGT8(4) 7037637 84 39 84 42 39 30 1 10 4 0 0.76 1.00 1.00 464 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ACTG2(6), ADCY3(3), ADCY9(6), ARF1(2), ARL4D(1), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), ERO1L(1), GNAS(14), PLCG1(10), PLCG2(6), SEC61A1(1), SEC61A2(1), SEC61B(1), SEC61G(1), TRIM23(2) 7323692 89 39 87 35 33 24 3 23 6 0 0.58 1.00 1.00 465 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(3), CAPN2(4), CAPNS1(1), CAPNS2(1), EGF(5), EGFR(10), ITGA1(4), ITGB1(4), MAPK1(2), MAPK3(1), MYL2(1), MYLK(9), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PTK2(7), PXN(2), TLN1(13) 6464962 83 39 81 41 30 23 4 16 10 0 0.80 1.00 1.00 466 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(2), BCL2(1), BID(1), BIRC2(2), BIRC3(4), CASP10(3), CASP3(1), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), DFFA(2), DFFB(2), GAS2(1), LMNA(5), MAP3K14(3), NFKB1(5), RELA(2), SPTAN1(13), TNFRSF10A(2), TNFRSF10B(2), TNFRSF25(2), TNFSF10(2), TRAF2(2) 6601643 68 38 68 20 17 18 2 21 10 0 0.38 1.00 1.00 467 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(3), ARSB(3), FUCA1(1), FUCA2(2), GALNS(2), GBA(4), GLB1(3), GNS(3), GUSB(3), HEXA(1), HEXB(3), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(2), HYAL2(4), IDS(3), IDUA(1), LCT(11), MAN2B1(8), MAN2B2(9), MAN2C1(4), MANBA(2), NAGLU(2), NEU1(1), NEU2(2), NEU3(2), NEU4(2), SPAM1(5) 6795121 93 38 92 38 35 33 2 15 8 0 0.54 1.00 1.00 468 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(14), ANAPC11(1), ANAPC2(3), ANAPC4(2), ANAPC5(2), ANAPC7(1), BTRC(3), CDC16(1), CDC20(2), CDC23(4), CDC26(1), CDC27(2), CUL1(10), CUL2(4), CUL3(4), FBXW11(5), FBXW7(11), FZR1(3), ITCH(3), SKP2(4), SMURF1(1), SMURF2(1), TCEB1(1), UBA1(1), UBE2D3(1), UBE2E3(3), WWP1(8), WWP2(10) 7995810 106 38 96 32 30 39 1 21 15 0 0.20 1.00 1.00 469 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 CDC42(1), CREB1(4), DAXX(3), DDIT3(3), ELK1(2), GRB2(1), HSPB1(1), HSPB2(1), MAP2K4(5), MAP2K6(2), MAP3K1(8), MAP3K5(3), MAP3K7(7), MAP3K9(5), MAPK14(1), MAPKAPK5(2), MAX(1), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), MKNK1(1), PLA2G4A(3), SHC1(3), STAT1(6), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TRAF2(2) 7265538 92 38 92 31 31 32 3 14 12 0 0.23 1.00 1.00 470 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), CDC42(1), CREB1(4), CREB3(3), CREB5(2), DUSP1(1), DUSP10(3), EEF2K(8), EIF4E(1), ELK1(2), HSPB1(1), IL1R1(3), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP3K10(6), MAP3K4(10), MAP3K5(3), MAP3K7(7), MAPK1(2), MAPK11(1), MAPK13(1), MAPK14(1), MAPKAPK5(2), MKNK1(1), MYEF2(4), NFKB1(5), NR2C2(3), SRF(1), TRAF6(4) 6586325 90 38 89 35 28 31 5 14 12 0 0.50 1.00 1.00 471 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(2), ABAT(4), ADSL(4), ADSS(3), AGXT(1), AGXT2(6), ASL(5), ASNS(4), CAD(7), CRAT(3), DARS(2), DDO(2), GAD1(3), GAD2(4), GOT1(2), GOT2(3), GPT(1), GPT2(3), NARS(3), PC(6) 5146752 68 37 66 28 31 18 1 15 3 0 0.58 1.00 1.00 472 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(3), ACTN2(15), ACTN3(2), BCAR1(4), CSK(3), CTNNA1(5), CTNNA2(13), CTNNB1(11), PTK2(7), PXN(2), VCL(2) 3758606 67 37 66 29 19 21 4 15 8 0 0.71 1.00 1.00 473 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(2), EGF(5), EGFR(10), GRB2(1), MAP2K1(4), MAPK1(2), MAPK3(1), PTPRB(12), RAF1(6), RASA1(10), SHC1(3), SOS1(4), SPRY1(2), SPRY2(1), SPRY3(4), SPRY4(3) 4961875 70 37 69 24 15 18 2 20 14 1 0.51 1.00 1.00 474 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BAD(1), BRAF(5), CREB1(4), CREB3(3), CREB5(2), DUSP4(1), DUSP6(1), DUSP9(2), EEF2K(8), EIF4E(1), GRB2(1), MAP2K1(4), MAP2K2(1), MAP3K8(1), MAPK1(2), MAPK3(1), MKNK1(1), MOS(3), NFKB1(5), RAP1A(2), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), SHC1(3), SOS1(4), SOS2(5), TRAF3(2) 5838942 77 37 76 31 24 24 1 18 10 0 0.67 1.00 1.00 475 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), ACO1(9), CLYBL(1), DLD(2), DLST(1), FH(2), IDH1(1), IDH2(1), IDH3A(1), IDH3B(3), IDH3G(2), MDH1(3), MDH2(1), OGDH(8), OGDHL(3), PC(6), PCK1(4), PCK2(6), SDHA(5), SDHB(4), SDHC(1), SUCLA2(3), SUCLG1(2), SUCLG2(4) 5898386 75 36 73 27 29 20 4 14 8 0 0.36 1.00 1.00 476 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(1), B3GNT7(4), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), CHST1(11), CHST2(8), CHST6(5), FUT8(3), ST3GAL1(3), ST3GAL2(4), ST3GAL3(2), ST3GAL4(3) 2455818 56 36 55 26 29 12 1 12 2 0 0.76 1.00 1.00 477 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(4), ACACA(15), ACACB(13), ACADM(1), ACAT1(3), ACAT2(3), ACSS1(7), ACSS2(3), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH6A1(1), ALDH9A1(4), EHHADH(2), HADHA(2), LDHAL6B(2), LDHB(2), LDHC(1), MCEE(3), MLYCD(3), MUT(3), PCCA(7), PCCB(2), SUCLA2(3), SUCLG1(2), SUCLG2(4) 7842939 110 36 106 34 30 29 2 26 23 0 0.22 1.00 1.00 478 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(4), ALAS1(2), ALAS2(4), BLVRA(2), COX10(1), COX15(3), CP(5), CPOX(1), EARS2(2), EPRS(6), FECH(5), FTH1(1), FTMT(2), GUSB(3), HCCS(1), HMOX1(3), MMAB(1), PPOX(2), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), UROD(1), UROS(3) 8152186 76 36 76 43 15 28 3 22 8 0 0.99 1.00 1.00 479 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLAT(6), DLD(2), DLST(1), FH(2), IDH2(1), IDH3A(1), IDH3B(3), IDH3G(2), MDH1(3), MDH2(1), OGDH(8), PC(6), PDHA1(1), PDHA2(4), PDHB(2), PDHX(2), PDK1(1), PDK3(2), PDP2(2), SDHA(5), SDHB(4), SDHC(1), SUCLA2(3), SUCLG1(2), SUCLG2(4) 5599047 69 36 68 33 22 17 3 19 8 0 0.90 1.00 1.00 480 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACAA2(1), ACADL(2), ACADM(1), ACADS(1), ACADSB(3), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH6A1(1), ALDH9A1(4), AOX1(3), BCAT1(2), BCKDHA(4), EHHADH(2), HADHA(2), HADHB(2), HIBADH(2), HMGCL(1), IVD(1), MCCC1(3), MCCC2(2), MCEE(3), MUT(3), OXCT1(4), PCCA(7), PCCB(2), SDS(1) 7124179 92 36 89 35 17 34 0 22 18 1 0.62 1.00 1.00 481 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ABAT(4), ACADS(1), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH5A1(3), ALDH9A1(4), EHHADH(2), GAD1(3), GAD2(4), HADHA(2), HMGCL(1), L2HGDH(1), OXCT1(4), PDHA1(1), PDHA2(4), PDHB(2), SDHB(4), SDS(1) 5090684 77 35 75 30 23 22 1 22 9 0 0.50 1.00 1.00 482 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD2(2), CD33(2), CD5(5), CD7(4), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(2), IL13(2), IL3(1), ITGAX(6), TLR2(3), TLR4(13), TLR7(3), TLR9(10) 3687923 62 35 58 31 21 13 6 17 5 0 0.90 1.00 1.00 483 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(5), AKR1B10(1), B4GALT1(2), B4GALT2(5), GAA(2), GALE(1), GALK1(2), GALK2(2), GALT(1), GANC(4), GCK(3), GLB1(3), HK1(6), HK2(6), HK3(3), HSD3B7(3), LALBA(1), LCT(11), MGAM(7), PFKL(7), PFKM(3), PFKP(8), PGM1(3), PGM3(6), RDH11(1), RDH12(1), UGP2(1) 7644031 98 35 97 43 46 33 4 9 6 0 0.54 1.00 1.00 484 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(4), POLA2(2), POLD1(7), POLD3(2), POLE(14), POLE2(2), POLE3(1), POLE4(1), POLG(4), POLG2(3), POLH(2), POLK(3), POLL(1), POLM(3), POLQ(14), PRIM1(1), PRIM2(3), REV1(5), REV3L(17) 8111175 89 35 89 43 22 29 2 18 18 0 0.95 1.00 1.00 485 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(11), CAP1(2), CCNB1(1), CDC25C(3), GNAI1(1), GNAS(14), GNB1(1), GNGT1(3), MAPK1(2), MAPK3(1), MYT1(12), PIN1(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RPS6KA1(6) 4049240 74 35 73 34 28 24 1 14 7 0 0.76 1.00 1.00 486 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(3), ANXA2(1), ANXA4(2), ANXA5(1), ANXA6(2), CYP11A1(2), EDN1(3), EDNRA(3), EDNRB(13), HSD11B1(1), HSD11B2(2), PLA2G4A(3), PRL(2), PTGDR(5), PTGER2(2), PTGER4(1), PTGFR(3), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(2) 4098427 63 35 62 26 15 22 4 13 9 0 0.69 1.00 1.00 487 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(4), CALM1(1), CALM2(2), CALM3(1), GNAQ(1), GRB2(1), JUN(2), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP3K1(8), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(4), PAK1(4), PLCG1(10), PTK2B(8), RAF1(6), SHC1(3), SOS1(4) 5608885 74 35 73 27 23 23 1 17 10 0 0.51 1.00 1.00 488 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(5), DYRK1B(6), GLI2(9), GLI3(16), GSK3B(2), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), SMO(6), SUFU(3) 3254678 62 35 62 31 18 17 2 17 8 0 0.81 1.00 1.00 489 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(2), CARS(4), DARS(2), EPRS(6), FARS2(7), GARS(1), HARS(4), IARS(7), KARS(3), LARS(3), LARS2(5), MARS(3), MARS2(1), NARS(3), QARS(5), RARS(2), SARS(4), TARS(6), WARS(3), WARS2(5), YARS(1) 6357797 77 34 76 24 23 30 2 18 4 0 0.24 1.00 1.00 490 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(1), ATG7(4), BECN1(1), GABARAPL1(3), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), IFNG(2), PIK3C3(8), PIK3R4(8), PRKAA1(1), PRKAA2(3), ULK1(11), ULK2(4), ULK3(2) 4186451 62 34 62 21 14 18 6 15 9 0 0.38 1.00 1.00 491 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(4), F2R(2), GNAI1(1), GNB1(1), GNGT1(3), ITGA1(4), ITGB1(4), MAP2K1(4), MAPK1(2), MAPK3(1), PLA2G4A(3), PLCB1(12), PTGS1(5), PTK2(7), RAF1(6), SYK(3), TBXAS1(2) 4809425 64 34 63 27 17 20 5 13 9 0 0.70 1.00 1.00 492 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(2), CALM3(1), EGR2(3), EGR3(1), GNAQ(1), MAP3K1(8), NFATC1(9), NFATC2(8), NFKB1(5), PLCG1(10), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RELA(2), VIP(1), VIPR2(4) 5516699 75 34 74 32 27 26 1 15 6 0 0.58 1.00 1.00 493 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP2(3), ACP5(2), ACPP(3), ACPT(1), ALPI(4), ALPL(3), ALPP(5), ALPPL2(4), CYP19A1(5), CYP1A1(3), CYP1A2(3), CYP2A13(4), CYP2A6(2), CYP2A7(3), CYP2B6(2), CYP2C18(5), CYP2C19(6), CYP2C9(1), CYP2D6(3), CYP2E1(5), CYP2F1(1), CYP2J2(2), CYP3A4(1), CYP3A5(1), CYP3A7(2), CYP4B1(1), CYP4F8(2), CYP51A1(3), PON1(1) 5772592 81 33 80 25 35 23 3 14 6 0 0.11 1.00 1.00 494 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(5), AKR1B10(1), ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), FPGT(3), FUK(1), GMDS(2), GMPPA(4), HK1(6), HK2(6), HK3(3), HSD3B7(3), LHPP(3), MTMR1(3), MTMR2(3), MTMR6(4), PFKFB2(5), PFKFB3(2), PFKFB4(1), PFKL(7), PFKM(3), PFKP(8), PGM2(2), PHPT1(3), PMM1(1), PMM2(1), RDH11(1), RDH12(1), TPI1(2), TSTA3(4) 7358127 99 33 99 32 43 35 3 14 4 0 0.070 1.00 1.00 495 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), ERCC3(3), GTF2B(1), GTF2E1(5), GTF2E2(2), GTF2F2(2), GTF2H1(1), ILK(2), MNAT1(2), POLR1A(8), POLR1B(2), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3B(6), POLR3D(1), POLR3E(1), POLR3K(1), TAF13(1), TAF5(2), TAF6(7), TAF7(4), TBP(3) 6943057 73 33 73 28 24 22 2 17 8 0 0.56 1.00 1.00 496 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(7), DDX20(3), ETS1(4), ETS2(1), HDAC2(4), HDAC5(4), JUN(2), NCOR2(15), RBL1(5), RBL2(1), SIN3A(5), SIN3B(8) 5094510 59 32 59 28 19 13 1 22 4 0 0.87 1.00 1.00 497 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2(4), F2R(2), F3(1), F5(9), F7(6), FGA(5), FGB(3), FGG(2), PROC(3), PROS1(6), SERPINC1(2), TFPI(3) 3250220 49 32 48 18 14 11 2 18 4 0 0.61 1.00 1.00 498 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CARM1(2), CBS(3), CTH(2), GGT1(8), LCMT1(1), LCMT2(7), MARS(3), MARS2(1), MAT1A(3), MAT2B(1), METTL6(1), PAPSS1(4), PAPSS2(2), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), SCLY(1), SEPHS1(1), SEPHS2(1), WBSCR22(2) 4921872 57 32 56 23 17 19 2 10 9 0 0.50 1.00 1.00 499 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(4), ACE2(5), AGT(2), AGTR1(1), AGTR2(1), ANPEP(3), CPA3(1), CTSG(3), ENPEP(8), LNPEP(9), MAS1(2), MME(5), NLN(7), REN(3), THOP1(5) 4178900 59 32 59 22 18 25 2 13 1 0 0.35 1.00 1.00 500 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(5), B4GALT1(2), B4GALT2(5), FBP2(3), GAA(2), GALE(1), GALK1(2), GALK2(2), GALT(1), GANAB(3), GCK(3), GLB1(3), HK1(6), HK2(6), HK3(3), LALBA(1), LCT(11), MGAM(7), PFKM(3), PFKP(8), PGM1(3), PGM3(6) 6455422 86 31 85 39 41 25 4 8 8 0 0.68 1.00 1.00 501 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(1), ALOX15(2), ALOX5(6), CYP1A2(3), CYP2C18(5), CYP2C19(6), CYP2C9(1), CYP2E1(5), CYP2J2(2), CYP3A4(1), CYP3A43(3), CYP3A5(1), CYP3A7(2), HSD3B7(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), RDH11(1), RDH12(1) 4734081 64 31 64 21 22 19 2 16 5 0 0.25 1.00 1.00 502 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(3), B4GALNT1(2), GLB1(3), HEXA(1), HEXB(3), LCT(11), SLC33A1(4), ST3GAL1(3), ST3GAL2(4), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC4(2), ST6GALNAC5(1), ST6GALNAC6(3), ST8SIA1(4), ST8SIA5(2) 3248951 50 31 50 24 21 14 1 12 2 0 0.76 1.00 1.00 503 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(11), GNAS(14), GNB1(1), GNGT1(3), PPP2CA(3), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAB2(1), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6) 3024169 57 30 56 22 22 19 1 8 7 0 0.59 1.00 1.00 504 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(5), EGFR(10), MAP2K1(4), MAP3K1(8), MAPK14(1), NCOR2(15), RARA(2), RXRA(3), THRA(4), THRB(5) 3390609 57 30 57 24 22 12 1 15 7 0 0.59 1.00 1.00 505 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(3), ARSD(1), ARSE(3), ASAH1(2), GAL3ST1(4), GALC(5), GBA(4), GLB1(3), LCT(11), NEU1(1), NEU2(2), NEU3(2), NEU4(2), PPAP2C(5), SMPD1(4), SPTLC2(3) 4767684 56 30 56 34 27 22 0 4 3 0 0.94 1.00 1.00 506 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(4), ELK1(2), GRB2(1), IL6(1), IL6ST(2), JAK1(4), JAK2(8), JAK3(3), JUN(2), MAP2K1(4), MAPK3(1), PTPN11(4), RAF1(6), SHC1(3), SOS1(4), SRF(1), STAT3(7) 4716154 57 30 57 23 10 24 1 16 5 1 0.66 1.00 1.00 507 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2A1(1), AP2M1(7), ARF1(2), BAD(1), BTK(2), EEA1(3), GRASP(1), GSK3A(1), GSK3B(2), LYN(4), PDPK1(1), PFKL(7), PFKM(3), PFKP(8), PLCG1(10), PRKCE(6), RAB5A(2), RPS6KB1(3), VAV2(8) 4945101 74 30 73 27 28 25 3 14 4 0 0.31 1.00 1.00 508 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(5), CCNB1(1), CCND1(1), CCND2(1), CCND3(2), CCNE1(3), CCNH(2), CDC25A(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(4), CDKN2D(1), RB1(8), RBL1(5), TFDP1(2) 3170298 44 29 43 22 11 13 1 15 4 0 0.86 1.00 1.00 509 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AMD1(2), BHMT(5), CBS(3), CTH(2), DNMT1(12), DNMT3A(7), DNMT3B(7), MARS(3), MARS2(1), MAT1A(3), MAT2B(1), MTR(9), SRM(1), TAT(1) 4087206 57 29 57 34 21 19 2 12 3 0 0.96 1.00 1.00 510 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(8), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(6), POLR3G(1), POLR3K(1) 4660849 49 29 49 18 14 18 1 13 3 0 0.49 1.00 1.00 511 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(5), ICAM1(2), ITGA4(8), ITGAL(7), ITGAM(5), ITGB1(4), ITGB2(6), SELE(3), SELL(4), SELP(2) 3170318 46 29 45 24 16 8 2 13 7 0 0.90 1.00 1.00 512 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(6), ARHGEF1(2), GNA12(1), GNAQ(1), GNB1(1), GNGT1(3), MYL2(1), MYLK(9), PLCB1(12), PPP1R12B(7), ROCK1(7) 4092582 50 29 50 24 16 13 0 12 8 1 0.91 1.00 1.00 513 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(4), ATP6V0A1(4), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), SHMT1(1) 2985174 42 28 42 18 7 19 3 11 2 0 0.68 1.00 1.00 514 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(7), EPHB1(14), FYN(5), ITGA1(4), ITGB1(4), L1CAM(3), LYN(4), RAP1B(4), SELP(2) 3129109 48 28 47 26 17 11 4 13 3 0 0.90 1.00 1.00 515 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(4), ATP6V0A1(4), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), SHMT1(1) 2985174 42 28 42 18 7 19 3 11 2 0 0.68 1.00 1.00 516 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(3), FUCA1(1), FUCA2(2), GLB1(3), HEXA(1), HEXB(3), LCT(11), MAN2B1(8), MAN2B2(9), MAN2C1(4), MANBA(2), NEU1(1), NEU2(2), NEU3(2), NEU4(2) 4008904 54 28 54 24 25 14 0 8 7 0 0.71 1.00 1.00 517 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(3), GALNS(2), GLB1(3), GNS(3), GUSB(3), HEXA(1), HEXB(3), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(2), HYAL2(4), IDS(3), IDUA(1), LCT(11), NAGLU(2), SPAM1(5) 4045038 53 28 52 23 17 22 2 10 2 0 0.64 1.00 1.00 518 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT5(3), DPM1(1), FUT8(3), MAN1B1(2), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(1), MGAT5(6), RPN1(1), RPN2(3) 3928604 41 28 40 28 13 10 1 13 4 0 1.00 1.00 1.00 519 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(2), CCR2(3), CCR3(4), CCR5(1), CD4(3), CXCR4(2), IFNG(2), IFNGR1(2), IFNGR2(1), IL12B(2), IL12RB1(4), IL12RB2(5), IL18R1(2), IL2(1), IL4R(1), TGFB1(3), TGFB2(6), TGFB3(4) 3952435 48 28 48 21 10 16 2 14 6 0 0.73 1.00 1.00 520 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2G(4), CAMK4(4), HDAC5(4), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), PPARA(3), PPP3CA(3), PPP3CB(1), SLC2A4(1), YWHAH(1) 3996049 44 28 44 16 15 12 2 11 4 0 0.43 1.00 1.00 521 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(4), ATP6V0A1(4), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), FDXR(2), SHMT1(1) 3173221 44 28 44 19 8 19 3 11 3 0 0.68 1.00 1.00 522 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(11), ADRB2(4), GNAS(14), PLCE1(9), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6) 2913100 53 28 52 22 17 21 0 10 5 0 0.63 1.00 1.00 523 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(13), EP300(15), HDAC3(4), IKBKB(3), NFKB1(5), RELA(2), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF6(4) 4411752 52 28 52 19 14 15 2 9 12 0 0.53 1.00 1.00 524 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(6), APOA1(2), APOA4(1), APOC1(1), APOC2(2), CETP(2), CYP7A1(3), HMGCR(5), LCAT(1), LDLR(4), LIPC(2), LPL(2), LRP1(23), SCARB1(3), SOAT1(5) 5414420 62 28 62 33 23 18 4 12 5 0 0.90 1.00 1.00 525 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(4), ATP6V0A1(4), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), SHMT1(1) 2985174 42 28 42 18 7 19 3 11 2 0 0.68 1.00 1.00 526 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(3), AKR1D1(2), ARSB(3), ARSD(1), ARSE(3), CYP11B1(2), CYP11B2(2), HSD11B1(1), HSD11B2(2), HSD17B2(1), HSD17B3(2), HSD3B1(1), HSD3B2(1), SRD5A1(2), SRD5A2(3), STS(4), SULT1E1(3), SULT2A1(1), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2B15(1), UGT2B4(2) 5416915 45 27 45 20 14 19 0 5 7 0 0.63 1.00 1.00 527 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(3), IL13(2), MAF(2), MAP2K3(1), MAPK14(1), NFATC1(9), NFATC2(8), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6) 2362721 41 27 41 21 13 18 0 8 2 0 0.61 1.00 1.00 528 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(3), G6PD(2), GCLM(2), GGT1(8), GPX1(1), GPX3(1), GPX4(3), GSS(1), GSTA1(2), GSTA2(1), GSTA4(1), GSTM1(1), GSTM3(1), GSTM4(1), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(3), IDH1(1), IDH2(1), MGST1(2), MGST2(1), MGST3(1), PGD(1) 3558156 43 27 42 16 16 14 1 11 1 0 0.40 1.00 1.00 529 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), G6PD(2), GPI(4), H6PD(3), PFKL(7), PFKM(3), PFKP(8), PGD(1), PGLS(2), PGM1(3), PGM3(6), PRPS1(1), PRPS1L1(2), PRPS2(3), TALDO1(2), TKTL1(4), TKTL2(5) 4796632 67 27 67 28 22 25 3 14 3 0 0.48 1.00 1.00 530 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(2), IL22RA1(1), IL22RA2(1), JAK1(4), JAK2(8), JAK3(3), SOCS3(3), STAT1(6), STAT3(7), STAT5A(1), STAT5B(4), TYK2(6) 3623192 46 27 46 19 11 17 1 10 6 1 0.68 1.00 1.00 531 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 BHMT(5), CBS(3), CTH(2), DNMT1(12), DNMT3A(7), DNMT3B(7), MARS(3), MARS2(1), MAT1A(3), MAT2B(1), MTR(9) 3430793 53 27 53 30 21 16 2 11 3 0 0.92 1.00 1.00 532 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(4), BLVRA(2), CP(5), CPOX(1), EPRS(6), FECH(5), GUSB(3), HCCS(1), HMOX1(3), PPOX(2), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2B15(1), UGT2B4(2), UROD(1), UROS(3) 5424189 44 27 44 24 7 18 1 12 6 0 0.95 1.00 1.00 533 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), GOT1(2), GOT2(3), GPT(1), GPT2(3), MDH1(3), MDH2(1), ME1(3), ME2(4), ME3(5), PGK1(1), PKLR(4), PKM2(2), TPI1(2) 3558642 45 26 44 18 17 11 3 11 3 0 0.59 1.00 1.00 534 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(7), POLE(14), POLG(4), POLL(1), POLQ(14) 3296060 40 26 40 25 12 10 1 10 7 0 0.98 1.00 1.00 535 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(5), GUSB(3), UGDH(4), UGP2(1), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), XYLB(5) 5195234 42 26 42 18 8 18 1 10 5 0 0.69 1.00 1.00 536 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(1), B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(1), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), FUT1(2), FUT4(1), FUT7(1), FUT9(3), GCNT2(2), ST3GAL6(2), ST8SIA1(4) 3165155 33 26 32 16 11 9 1 11 1 0 0.83 1.00 1.00 537 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), GOT1(2), GOT2(3), GPT(1), GPT2(3), MDH1(3), MDH2(1), ME1(3), ME3(5), PGK1(1), PGK2(1), PKLR(4), PKM2(2), TKTL1(4), TKTL2(5), TPI1(2) 3980363 51 26 50 24 19 14 4 12 2 0 0.78 1.00 1.00 538 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(4), ELK1(2), GRB2(1), IL2(1), IL2RA(1), IL2RG(3), JAK1(4), JAK3(3), JUN(2), LCK(1), MAP2K1(4), MAPK3(1), MAPK8(4), RAF1(6), SHC1(3), SOS1(4), STAT5A(1), STAT5B(4), SYK(3) 4610106 52 26 51 19 9 21 1 13 7 1 0.55 1.00 1.00 539 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(2), CD3E(3), CD3G(2), CD4(3), IFNG(2), IL12B(2), IL12RB1(4), IL12RB2(5), JAK2(8), STAT4(4), TYK2(6) 2899352 42 26 41 17 5 16 3 10 8 0 0.75 1.00 1.00 540 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(5), DNMT1(12), MTNR1A(3), MTNR1B(2), PTAFR(2), PTGDR(5), PTGER2(2), PTGER4(1), PTGFR(3), TBXA2R(7) 2179935 42 26 42 22 15 12 3 10 2 0 0.79 1.00 1.00 541 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(4), GBA3(1), LPO(2), MPO(5), PRDX6(1), TPO(13), TYR(5) 1904516 31 26 31 17 11 6 0 11 3 0 0.93 1.00 1.00 542 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(3), IKBKB(3), JUN(2), LTA(2), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP3K1(8), MAP3K14(3), MAP4K2(4), MAPK14(1), MAPK8(4), NFKB1(5), RELA(2), TANK(2), TNF(2), TNFRSF1A(3), TRAF2(2) 4745563 54 26 54 21 15 17 1 14 7 0 0.59 1.00 1.00 543 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(3), C9orf95(1), CD38(2), ENPP1(1), ENPP3(3), NADK(3), NADSYN1(5), NMNAT1(1), NMNAT2(1), NMNAT3(1), NNMT(2), NNT(7), NT5C(1), NT5C1A(1), NT5C1B(4), NT5C2(5), NUDT12(1) 4251738 42 25 42 24 13 15 2 8 3 1 0.93 1.00 1.00 544 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(7), GRB2(1), IL3(1), IL3RA(4), JAK2(8), MAP2K1(4), MAPK3(1), PTPN6(3), RAF1(6), SHC1(3), SOS1(4), STAT5A(1), STAT5B(4) 3498185 47 25 47 18 13 18 1 9 6 0 0.56 1.00 1.00 545 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(4), EPX(4), LPO(2), MPO(5), PRDX6(1), SHMT1(1), SHMT2(4), TPO(13) 2326526 35 25 35 14 11 6 2 10 6 0 0.62 1.00 1.00 546 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(2), CDK5R1(1), DAB1(6), FYN(5), LRP8(3), RELN(21), VLDLR(3) 2783276 41 25 41 20 10 16 1 9 5 0 0.84 1.00 1.00 547 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(4), CD44(5), FCGR3A(1), IL1B(1), SELL(4), TGFB1(3), TGFB2(6), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TNFRSF8(2), TNFSF8(1) 2613615 33 25 33 16 10 10 0 8 5 0 0.66 1.00 1.00 548 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6(1), JAK1(4), JAK2(8), JAK3(3), PIAS3(1), PTPRU(13), REG1A(4), STAT3(7) 3009862 43 25 43 15 13 13 0 13 3 1 0.47 1.00 1.00 549 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(3), CD3G(2), CD8A(2), ICAM1(2), ITGAL(7), ITGB2(6), PTPRC(16) 2128359 40 25 38 18 11 10 1 12 6 0 0.80 1.00 1.00 550 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(2), CSF1R(7), EGF(5), EGFR(10), GRB2(1), MET(4), PDGFRA(4), SH3GLB1(1), SH3GLB2(3), SH3KBP1(5) 3843415 42 24 42 32 16 9 2 7 8 0 0.99 1.00 1.00 551 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(11), ADRB2(4), CFTR(3), GNAS(14), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6) 2580035 47 24 46 17 19 18 0 7 3 0 0.44 1.00 1.00 552 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(2), BCAT2(1), IARS(7), IARS2(3), ILVBL(3), LARS(3), LARS2(5), PDHA1(1), PDHA2(4), PDHB(2), VARS(8), VARS2(4) 3680181 43 24 43 15 13 10 2 14 4 0 0.55 1.00 1.00 553 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP2(3), ACP5(2), ACP6(3), ACPP(3), ACPT(1), ALPI(4), ALPL(3), ALPP(5), ALPPL2(4), CYP3A4(1), CYP3A43(3), CYP3A5(1), CYP3A7(2), DHRS3(1), DHRS7(1), DHRSX(2), PON1(1), PON2(2) 3543969 42 24 41 17 16 14 1 5 6 0 0.48 1.00 1.00 554 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(4), B3GALNT1(2), B3GALT5(1), FUT1(2), FUT9(3), HEXA(1), HEXB(3), NAGA(3), ST3GAL1(3), ST3GAL2(4), ST8SIA1(4) 2127305 30 24 30 12 11 5 2 11 1 0 0.69 1.00 1.00 555 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(5), ICAM1(2), ITGA4(8), ITGAL(7), ITGB1(4), ITGB2(6), SELE(3), SELL(4) 2407931 39 24 38 17 13 8 2 10 6 0 0.63 1.00 1.00 556 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(3), FUCA1(1), FUCA2(2), GLB1(3), HEXA(1), HEXB(3), LCT(11), MAN2C1(4), MANBA(2), NEU1(1), NEU2(2), NEU3(2), NEU4(2) 3250755 37 24 37 20 17 9 0 6 5 0 0.91 1.00 1.00 557 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), G6PD(2), GPI(4), H6PD(3), PFKM(3), PFKP(8), PGD(1), PGLS(2), PGM1(3), PGM3(6), PRPS1(1), PRPS1L1(2), PRPS2(3), TAL1(1), TALDO1(2) 4028005 52 24 52 23 17 17 2 13 3 0 0.62 1.00 1.00 558 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(3), CD3G(2), CD4(3), FYN(5), HLA-DRA(3), HLA-DRB1(1), LCK(1), PTPRC(16), ZAP70(4) 1786448 38 24 36 19 7 12 1 13 5 0 0.91 1.00 1.00 559 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(4), GBA(4), GBA3(1), LPO(2), MPO(5), PRDX6(1), TPO(13) 1660878 30 23 30 13 13 7 0 8 2 0 0.69 1.00 1.00 560 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPL10L(5), RPL12(1), RPL13(1), RPL13A(1), RPL14(1), RPL18A(1), RPL19(2), RPL23A(1), RPL27A(1), RPL3(2), RPL31(1), RPL34(1), RPL36A(1), RPL6(1), RPL8(2), RPL9(2), RPS10(1), RPS11(1), RPS13(1), RPS20(1), RPS23(1), RPS3(1), RPS3A(1), RPS5(2), RPS6(1), RPSA(4) 4478789 39 23 39 19 10 17 1 7 4 0 0.89 1.00 1.00 561 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT5(3), FUT8(3), ST3GAL1(3), ST3GAL2(4), ST3GAL3(2), ST3GAL4(3) 1553428 27 23 26 10 10 8 0 8 1 0 0.59 1.00 1.00 562 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(4), MBTPS1(9), MBTPS2(2), SCAP(7), SREBF1(4), SREBF2(7) 2320505 34 23 34 16 11 13 1 7 2 0 0.68 1.00 1.00 563 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(3), CD3G(2), CD4(3), ICAM1(2), ITGAL(7), ITGB2(6), PTPRC(16) 2234803 41 23 39 21 10 11 1 13 6 0 0.92 1.00 1.00 564 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(2), CALM3(1), CCL2(1), CCR5(1), CXCR4(2), GNAQ(1), JUN(2), MAPK14(1), MAPK8(4), PLCG1(10), PTK2B(8) 2728483 34 22 33 13 14 10 0 9 1 0 0.48 1.00 1.00 565 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(3), GALNS(2), GLB1(3), GNS(3), GUSB(3), HEXA(1), HEXB(3), IDS(3), IDUA(1), LCT(11), NAGLU(2) 2824541 35 22 35 19 11 14 1 7 2 0 0.85 1.00 1.00 566 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(4), ABCC2(12), ABCG2(3), BCHE(3), CES1(7), CES2(5), CYP3A4(1), CYP3A5(1), UGT1A1(1), UGT1A5(3), UGT1A7(1) 4535993 41 22 41 22 6 19 2 8 6 0 0.88 1.00 1.00 567 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(2), ITGAL(7), ITGAM(5), ITGB2(6), SELE(3), SELL(4) 2073837 32 22 32 18 14 5 1 7 5 0 0.91 1.00 1.00 568 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(2), CREBBP(13), DFFA(2), DFFB(2), GZMA(2), HMGB2(2), PRF1(1), SET(2) 2089941 26 22 26 11 3 9 2 6 6 0 0.75 1.00 1.00 569 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(5), CCNE1(3), CDC34(1), CDK2(2), CUL1(10), RB1(8), SKP2(4), TFDP1(2) 1701327 35 22 34 15 6 12 1 12 4 0 0.69 1.00 1.00 570 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(2), IL13RA2(7), IL4R(1), JAK1(4), JAK2(8), TYK2(6) 2071061 30 22 30 14 7 8 2 8 4 1 0.84 1.00 1.00 571 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(2), IL13RA2(7), IL4R(1), JAK1(4), JAK2(8), TYK2(6) 2071061 30 22 30 14 7 8 2 8 4 1 0.84 1.00 1.00 572 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(4), JAK2(8), JAK3(3), MAPK1(2), MAPK3(1), STAT3(7), TYK2(6) 2302000 31 22 31 14 5 13 0 8 4 1 0.81 1.00 1.00 573 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(4), ALAS1(2), ALAS2(4), CPO(2), FECH(5), GATA1(2), HBB(1), UROD(1), UROS(3) 1559013 24 21 24 10 7 4 2 9 2 0 0.75 1.00 1.00 574 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 DUSP1(1), IKBKAP(3), IKBKB(3), MAP3K1(8), MAP3K14(3), NFKB1(5), RELA(2), TNFAIP3(5), TRAF3(2), TRAF6(4) 3601882 36 21 36 12 14 7 2 8 5 0 0.52 1.00 1.00 575 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP51A1(3), DHCR24(2), DHCR7(2), EBP(1), FDPS(4), GGCX(1), GGPS1(2), HMGCR(5), HSD17B7(1), IDI2(1), LSS(5), MVD(2), MVK(4), NQO1(3), NSDHL(3), SC4MOL(2), SC5DL(1), SQLE(4), TM7SF2(1), VKORC1(1) 3821478 48 21 47 20 16 11 3 14 4 0 0.76 1.00 1.00 576 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 DUSP1(1), IKBKAP(3), IKBKB(3), LTA(2), MAP3K1(8), MAP3K14(3), NFKB1(5), RELA(2), TANK(2), TNFAIP3(5), TNFRSF1B(1), TRAF1(2), TRAF2(2), TRAF3(2) 4450001 41 21 41 17 17 10 1 8 5 0 0.68 1.00 1.00 577 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(4), ALAS1(2), ALAS2(4), CPOX(1), FECH(5), PPOX(2), UROD(1), UROS(3) 1504399 22 20 22 10 6 4 1 9 2 0 0.84 1.00 1.00 578 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(3), HK1(6), HK2(6), HK3(3), IMPA1(3), ISYNA1(2), PGM1(3), PGM3(6), TGDS(2) 2298043 34 20 34 14 14 13 3 2 2 0 0.37 1.00 1.00 579 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(3), CTH(2), GGT1(8), MARS(3), MARS2(1), MAT1A(3), MAT2B(1), PAPSS1(4), PAPSS2(2), SCLY(1), SEPHS1(1) 2439040 29 20 28 14 10 10 1 5 3 0 0.71 1.00 1.00 580 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(2), CDK5R1(1), EGR1(3), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), NGFR(5), RAF1(6) 1610005 25 19 25 15 8 9 1 6 1 0 0.89 1.00 1.00 581 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(5), CCNA2(1), CCND1(1), CCNE1(3), CCNE2(1), CDK2(2), CDKN2A(4), E2F2(2), PRB1(2) 1714247 21 19 21 18 3 8 1 7 2 0 0.99 1.00 1.00 582 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(4), AGT(2), AGTR1(1), AGTR2(1), BDKRB2(3), KNG1(4), NOS3(3), REN(3) 1942346 21 18 21 11 7 7 1 3 3 0 0.71 1.00 1.00 583 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR2(2), ARPC1A(3), ARPC1B(1), ARPC4(1), NCK1(3), NCKAP1(6), NTRK1(4), PSMA7(3), WASF1(4), WASF2(2), WASF3(3), WASL(1) 3016215 34 18 34 28 16 10 1 4 3 0 1.00 1.00 1.00 584 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(5), EGFR(10), HGS(3), RAB5A(2), TF(6), TFRC(1) 2555404 30 18 30 16 5 8 1 11 5 0 0.89 1.00 1.00 585 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(7), FARSA(3), FARSB(1), GOT1(2), GOT2(3), PAH(5), TAT(1), YARS(1), YARS2(1) 1725043 24 18 24 10 8 8 0 6 2 0 0.71 1.00 1.00 586 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), GRB2(1), IL2RG(3), IL4R(1), IRS1(7), JAK1(4), JAK3(3), RPS6KB1(3), SHC1(3) 2924931 27 18 26 19 6 10 0 6 4 1 0.99 1.00 1.00 587 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(3), HDAC9(1), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), MYOD1(3), YWHAH(1) 1559440 21 18 21 11 9 5 2 4 1 0 0.78 1.00 1.00 588 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(3), CD38(2), ENPP1(1), ENPP3(3), NADSYN1(5), NMNAT1(1), NMNAT2(1), NNMT(2), NNT(7), NT5C(1) 2870773 26 18 26 16 5 9 2 7 2 1 0.96 1.00 1.00 589 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(3), DLL1(3), FURIN(2), NOTCH1(15), PSEN1(1) 1794737 24 18 24 17 10 6 1 4 3 0 0.92 1.00 1.00 590 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAP3K14(3), MAPK14(1), MAPK8(4), NFKB1(5), RELA(2), TNFRSF13B(1), TNFRSF17(1), TRAF2(2), TRAF3(2), TRAF6(4) 2878967 25 18 25 10 5 6 1 10 3 0 0.80 1.00 1.00 591 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(2), HLA-DRA(3), HLA-DRB1(1), IFNG(2), IFNGR1(2), IFNGR2(1), IL12B(2), IL12RB1(4), IL12RB2(5), IL18R1(2), IL2(1), IL2RA(1), IL4R(1) 2513517 27 18 27 13 7 8 2 7 3 0 0.71 1.00 1.00 592 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(3), CAPN1(3), CAPNS1(1), CAPNS2(1), CDK5(2), CDK5R1(1), CSNK1D(2), GSK3B(2), MAPT(4), PPP2CA(3) 1836853 22 17 21 13 10 8 0 2 2 0 0.86 1.00 1.00 593 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(9) 2647352 28 17 28 15 10 11 0 5 2 0 0.84 1.00 1.00 594 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(2), BAD(1), BAK1(2), BCL10(1), BCL2(1), BCL2L11(1), BID(1), CASP8AP2(9), CASP9(1), CES1(7) 2231072 26 17 26 10 8 8 0 9 1 0 0.68 1.00 1.00 595 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(2), UBE2A(2), UBE2B(1), UBE2D3(1), UBE2E3(3), UBE2G2(2), UBE2H(1), UBE2I(2), UBE2J2(3), UBE2L3(1), UBE2L6(1), UBE2N(1), UBE3A(5) 2075177 26 17 26 14 9 7 1 5 4 0 0.78 1.00 1.00 596 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(2), IL13(2), IL16(2), IL2(1), IL3(1), IL6(1), IL8(1), LTA(2), TNF(2) 1974971 20 16 20 10 5 7 1 7 0 0 0.75 1.00 1.00 597 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 CDKN1A(1), EPOR(2), GRIN1(4), HIF1A(2), JAK2(8), NFKB1(5), RELA(2), SOD2(1) 2500547 25 15 25 11 6 8 1 4 6 0 0.79 1.00 1.00 598 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(9), GRHPR(2), HAO1(1), MDH1(3), MDH2(1), MTHFD1(3), MTHFD1L(2), MTHFD2(1) 2532789 22 15 21 13 5 11 1 3 2 0 0.87 1.00 1.00 599 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(9), GRHPR(2), HAO1(1), MDH1(3), MDH2(1), MTHFD1(3), MTHFD1L(2), MTHFD2(1) 2651844 22 15 21 13 5 11 1 3 2 0 0.87 1.00 1.00 600 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(4), ADSS(3), IMPDH1(1), MTHFD2(1), POLD1(7), POLG(4), PRPS2(3), RRM1(4), SRM(1) 2450604 28 15 28 11 8 14 1 3 2 0 0.47 1.00 1.00 601 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(19), RANGAP1(4) 1671751 24 15 22 14 1 10 2 9 2 0 0.92 1.00 1.00 602 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(1), MMP2(4), MMP9(6), RECK(5), TIMP2(1), TIMP3(2) 1483464 19 15 19 12 7 5 0 3 4 0 0.92 1.00 1.00 603 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(2), B3GALT2(5), B3GALT5(1), B3GNT5(1), FUT1(2), ST3GAL3(2), ST3GAL4(3) 1428103 16 14 16 7 8 2 0 6 0 0 0.75 1.00 1.00 604 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(2), BCL2(1), CASP3(1), CASP9(1), CYCS(1), DAXX(3), FAS(3), HSPB1(1), HSPB2(1), MAPKAPK3(3), TNF(2) 2236054 20 14 20 14 8 7 0 3 2 0 0.95 1.00 1.00 605 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), GAD1(3), HDC(5), PNMT(3), TH(1), TPH1(1) 1186592 15 12 15 8 5 4 2 4 0 0 0.81 1.00 1.00 606 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(3), ALDH1A2(5), BCMO1(2), RDH5(2) 770906 12 11 12 11 3 3 0 5 1 0 0.99 1.00 1.00 607 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(3), CD80(1), HLA-DRA(3), HLA-DRB1(1), IL10(1), IL2(1) 791778 10 10 10 6 2 4 0 4 0 0 0.88 1.00 1.00 608 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 EHHADH(2), HADH(2), HADHA(2), HSD17B4(2), NTAN1(2), SIRT1(3), SIRT2(1), SIRT5(3), SIRT7(1), VNN2(1) 2346943 19 10 18 10 3 4 3 4 5 0 0.88 1.00 1.00 609 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(4), AASDH(4), AASS(2), KARS(3) 1384664 13 10 13 9 2 9 1 1 0 0 0.92 1.00 1.00 610 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR2(2), ARPC1A(3), ARPC1B(1), ARPC4(1), CDC42(1), WASF1(4), WASL(1) 1611048 14 9 14 17 6 5 1 1 1 0 1.00 1.00 1.00 611 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(3), CHRNA1(3), SNAP25(1), STX1A(1) 647538 8 8 8 5 3 1 0 4 0 0 0.89 1.00 1.00 612 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(3), PLCD1(1), TGM2(4) 984737 8 8 8 5 6 1 0 1 0 0 0.79 1.00 1.00 613 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(3), HLA-DRA(3), HLA-DRB1(1) 472988 7 7 7 6 1 3 0 3 0 0 0.96 1.00 1.00 614 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(4), RAB27A(3), RAB5A(2), RAB6A(1) 852681 11 7 11 12 2 6 0 2 1 0 0.98 1.00 1.00 615 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(2), ST3GAL3(2) 1007483 4 4 4 6 2 0 0 2 0 0 0.99 1.00 1.00 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 100814 0 0 0 0 0 0 0 0 0 0 1.00 1.00 1.00