rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(5)	143247	5	5	5	1	1	0	1	1	2	0	0.55	0.019	1.00
2	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(3), CD3G(2)	225536	5	5	4	1	0	2	1	0	2	0	0.68	0.10	1.00
3	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(3), ERBB4(18), NRG2(5), NRG3(9), PSEN1(1)	1780945	36	27	35	6	8	13	4	7	4	0	0.030	0.19	1.00
4	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(2), DCN(2), FMOD(9), KERA(1), LUM(3)	721456	17	15	17	4	8	3	0	5	1	0	0.29	0.26	1.00
5	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(5), GABRA2(5), GABRA3(5), GABRA4(4), GABRA5(5), GABRA6(5), GPX1(1), PRKCE(6)	1565795	36	24	36	9	13	7	5	10	1	0	0.13	0.28	1.00
6	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(5), CPS1(15), GLS(4), GLUD1(4), GOT1(2)	1545002	32	25	32	7	9	9	2	10	2	0	0.14	0.38	1.00
7	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCL5(1), CCR3(4), HLA-DRA(3), HLA-DRB1(1), IL3(1)	602660	11	10	11	3	4	4	0	2	1	0	0.35	0.38	1.00
8	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	11	DNM1(5), GABRA1(5), GABRA2(5), GABRA3(5), GABRA4(4), GABRA5(5), GABRA6(5), GPHN(7), UBQLN1(4)	2211584	45	26	45	9	11	10	6	13	5	0	0.058	0.42	1.00
9	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(2), IL12B(2), IL2(1)	592301	7	7	7	1	0	3	1	3	0	0	0.33	0.42	1.00
10	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3), SUCLA2(3)	416247	6	6	6	0	3	0	0	1	2	0	0.19	0.51	1.00
11	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(2), NR3C1(5), PPARG(1), RXRA(3), TNF(2)	1144281	14	12	14	3	3	4	1	5	1	0	0.26	0.53	1.00
12	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3E(3), CD3G(2), IFNG(2), IL2(1), IL2RA(1), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6), TGFBR3(2), TOB1(1), TOB2(5)	2099747	38	26	37	9	6	15	3	10	4	0	0.21	0.58	1.00
13	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), MIOX(1), UGDH(4)	1679038	29	23	29	5	6	8	0	11	4	0	0.067	0.58	1.00
14	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6)	1120150	22	17	21	5	2	9	0	6	5	0	0.26	0.60	1.00
15	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(4), GAD1(3), GAD2(4), GGT1(8)	1131431	20	17	19	5	9	4	0	7	0	0	0.24	0.60	1.00
16	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(3), IL8(1), SLPI(1)	339001	5	4	5	2	2	2	0	1	0	0	0.67	0.68	1.00
17	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP3(1), CASP8(6), CFL1(1)	763348	9	8	9	2	1	2	1	3	2	0	0.53	0.69	1.00
18	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(1), TGDS(2), UGDH(4), UXS1(3)	777847	11	10	11	3	4	3	1	2	1	0	0.44	0.77	1.00
19	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(1), FLT3(7), IGF1(2), IL11(2), IL3(1), IL6(1), KITLG(3), TGFB1(3), TGFB2(6), TGFB3(4)	1643883	30	22	30	7	7	11	0	8	4	0	0.19	0.78	1.00
20	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4)	2628366	47	29	46	9	7	15	0	16	9	0	0.047	0.78	1.00
21	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(2), CAT(4), GH1(3), GHR(5), IGF1(2), IGF1R(11), PIK3R1(7), SHC1(3), SOD2(1)	2192366	38	23	38	9	7	17	2	6	6	0	0.11	0.80	1.00
22	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1R(5), C1S(4), C2(2), C3(16), C5(9), C6(8), C7(2), C8A(6), C8B(8), C9(3), MASP1(4)	4166093	68	37	67	14	20	15	3	20	9	1	0.040	0.81	1.00
23	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(2)	320318	3	3	3	0	2	1	0	0	0	0	0.32	0.82	1.00
24	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(1), CASP7(2), DFFA(2), DFFB(2), ENDOG(1), HMGB2(2), TOP2A(6), TOP2B(10)	1886072	26	16	23	4	4	10	1	4	7	0	0.15	0.83	1.00
25	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOB(4), ALDOC(3), TPI1(2)	769932	10	9	10	2	2	3	0	5	0	0	0.35	0.84	1.00
26	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(4), GLS2(5), GLUD1(4), GLUD2(7)	895266	20	14	20	5	6	6	0	7	1	0	0.29	0.85	1.00
27	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(3), HLCS(1), SPCS3(1)	613372	5	5	5	0	3	0	0	2	0	0	0.15	0.86	1.00
28	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(4), GGPS1(2), IDI2(1), SQLE(4)	859784	11	9	10	2	4	2	0	2	3	0	0.38	0.87	1.00
29	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(8), HSD17B1(3), HSD17B2(1), HSD17B3(2), HSD17B4(2), HSD17B7(1), HSD3B1(1), HSD3B2(1)	1609144	21	19	21	5	4	8	1	4	4	0	0.14	0.89	1.00
30	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), CD36(2), FYN(5), JUN(2), MAPK14(1), THBS1(9)	1459365	20	15	20	4	6	7	0	5	2	0	0.13	0.90	1.00
31	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(3), PDXK(4), PDXP(1), PNPO(1), PSAT1(2)	954275	11	10	11	4	2	3	0	3	2	1	0.59	0.90	1.00
32	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(3), PARK2(9), SNCAIP(7), UBE2F(3), UBE2G2(2), UBE2L3(1), UBE2L6(1)	1271878	26	20	26	6	9	9	0	5	3	0	0.11	0.91	1.00
33	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(6), AOC2(4), AOC3(3), CES1(7), ESD(1)	1196455	21	16	21	6	4	7	1	8	0	1	0.38	0.93	1.00
34	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(3), CCL2(1), IL6(1), LDLR(4), LPL(2)	1053715	11	11	11	4	3	2	0	3	3	0	0.50	0.93	1.00
35	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(4), CD4(3), HLA-DRA(3), HLA-DRB1(1), IL1B(1), IL5RA(1), IL6(1)	1061395	15	13	15	5	3	5	0	5	2	0	0.52	0.93	1.00
36	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(2), FOSB(2), GRIA2(13)	739892	17	13	17	6	5	9	0	2	1	0	0.42	0.94	1.00
37	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1), LIPT1(3)	303839	4	4	4	2	0	2	0	1	1	0	0.75	0.94	1.00
38	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(9), FH(2), IDH1(1), IDH2(1), MDH1(3), MDH2(1), SDHB(4), SUCLA2(3)	1762795	24	18	23	4	10	5	2	5	2	0	0.066	0.94	1.00
39	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(3), HGD(2)	443440	7	6	7	4	4	0	0	3	0	0	0.84	0.94	1.00
40	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(1), ACADS(1), ACAT1(3), HADHA(2)	1072173	9	7	8	2	2	3	0	0	4	0	0.28	0.95	1.00
41	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(2), COQ3(2), COQ6(3), COQ7(1), NDUFA13(1)	796152	9	8	9	3	4	4	0	1	0	0	0.60	0.95	1.00
42	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS1(4), PAPSS2(2), SULT1A2(4), SULT1E1(3), SULT2A1(1)	1211968	16	12	16	4	7	8	0	0	1	0	0.31	0.95	1.00
43	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1R(5), C1S(4), C2(2), C3(16), C5(9), C6(8), C7(2), C8A(6), C9(3), MASP1(4), MASP2(2), MBL2(1)	4268350	63	34	63	14	18	16	3	17	8	1	0.057	0.95	1.00
44	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(4), SQLE(4)	645123	8	6	8	2	3	2	0	2	1	0	0.46	0.96	1.00
45	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(3), MTMR1(3), MTMR2(3), MTMR6(4), NFS1(2), PHPT1(3), THTPA(1), TPK1(2)	1276237	21	13	21	4	7	10	1	2	1	0	0.14	0.96	1.00
46	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	APC(20), CREBBP(13), EP300(15), MAP2K1(4), MAP3K7(7), MAPK3(1), SKIL(3), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6)	4743776	84	43	83	20	16	28	4	16	19	1	0.096	0.96	1.00
47	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(6), CYP2C9(1)	401261	7	6	7	3	2	1	0	4	0	0	0.80	0.96	1.00
48	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(2), CD3E(3), CD3G(2), CD4(3), CD58(1), CD8A(2), CSF3(1), IL3(1), IL6(1), IL8(1), KITLG(3)	1228410	22	18	21	8	3	8	1	6	4	0	0.63	0.96	1.00
49	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(4), CTH(2), GOT1(2), GOT2(3), LDHB(2), LDHC(1), MPST(1)	1332052	15	12	15	3	5	6	1	1	2	0	0.16	0.96	1.00
50	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(16), C5(9), C6(8), C7(2), C8A(6), C9(3)	2519797	44	28	44	11	14	11	2	12	5	0	0.14	0.97	1.00
51	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(2), CAMP(1), DAG1(7), GNAQ(1), ITPKA(1), ITPKB(6)	1188008	18	16	18	6	6	5	0	4	2	1	0.50	0.97	1.00
52	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(2)	356672	4	3	4	2	2	1	1	0	0	0	0.73	0.97	1.00
53	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1R(5), C1S(4), C2(2), C3(16), C5(9), C6(8), C7(2), C8A(6), C9(3)	3511720	56	32	56	13	16	13	3	16	7	1	0.11	0.97	1.00
54	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(1), TGDS(2), UGDH(4), UGP2(1), UXS1(3)	986258	12	11	12	4	5	3	1	2	1	0	0.51	0.98	1.00
55	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(2), IFNGR2(1), JAK1(4), JAK2(8), STAT1(6)	1630706	23	15	23	7	5	8	1	5	3	1	0.42	0.98	1.00
56	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(2), BIRC3(4), CASP8(6), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF2(2)	1640439	20	17	20	6	6	4	1	7	2	0	0.39	0.98	1.00
57	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(6), BMPR1A(1), BMPR1B(3), BMPR2(10)	1235622	20	16	19	6	7	6	0	3	2	2	0.53	0.98	1.00
58	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(4), ALPL(3), ALPP(5), ALPPL2(4), FPGS(1), GGH(1), SPR(2)	1274303	20	15	19	7	11	3	0	3	3	0	0.36	0.98	1.00
59	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), CHPT1(1), LCMT1(1), LCMT2(7), METTL6(1), PCYT1A(7), PCYT1B(3), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), WBSCR22(2)	2787562	38	24	38	7	13	12	1	7	5	0	0.031	0.98	1.00
60	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(11), GNAS(14), GNB1(1), GNGT1(3), PRKACA(1), PRKAR1A(2)	1300583	32	18	31	9	16	8	0	4	4	0	0.33	0.98	1.00
61	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(2), BAK1(2), BCL2(1), BID(1), BIRC2(2), BIRC3(4), CASP3(1), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), DFFA(2), DFFB(2), DIABLO(1), ENDOG(1)	2685524	30	20	30	4	7	11	1	7	4	0	0.048	0.98	1.00
62	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4)	1574973	32	23	32	10	7	7	0	13	5	0	0.42	0.99	1.00
63	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4)	1574973	32	23	32	10	7	7	0	13	5	0	0.42	0.99	1.00
64	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(1), HS3ST1(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), XYLT1(7), XYLT2(4)	1263913	25	18	25	7	11	9	1	1	3	0	0.23	0.99	1.00
65	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(1), HS3ST1(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), XYLT1(7), XYLT2(4)	1263913	25	18	25	7	11	9	1	1	3	0	0.23	0.99	1.00
66	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25A(2), CDC25B(4), CDC25C(3), CSK(3), GRB2(1), PTPRA(5)	1823577	19	14	19	3	7	5	0	1	6	0	0.070	0.99	1.00
67	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(1), GGT1(8), SHMT1(1), SHMT2(4)	818435	14	14	13	6	4	1	1	5	3	0	0.62	0.99	1.00
68	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	RB1(8), SP1(3), SP3(3)	1320400	14	12	13	4	1	8	0	2	3	0	0.39	0.99	1.00
69	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(2), CDC25B(4), CDKN1A(1), CHEK1(2), NEK1(4), WEE1(1)	1397462	14	12	14	3	2	5	0	3	4	0	0.46	0.99	1.00
70	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(3), ACAT2(3), ACYP2(1), EHHADH(2), GCDH(3), HADHA(2), SDHB(4), SDS(1)	1546604	19	12	18	4	4	10	2	0	3	0	0.084	0.99	1.00
71	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD3E(3), CD3G(2), CD4(3)	638386	9	8	8	7	0	4	1	2	2	0	0.98	0.99	1.00
72	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), FUT1(2), FUT9(3), GCNT2(2), ST8SIA1(4)	1209262	12	10	12	4	3	3	0	6	0	0	0.56	0.99	1.00
73	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(1), ACADS(1), ACSL1(2), ACSL3(6), ACSL4(3), CPT1A(4), CPT2(4), EHHADH(2), HADHA(2), SCP2(3), SLC25A20(2)	3333189	32	19	31	6	6	7	3	7	9	0	0.083	0.99	1.00
74	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(4), F13A1(9), F2(4), F2R(2), FGA(5), FGB(3), FGG(2), PLAT(2), PLAU(2), PLG(10), SERPINB2(3), SERPINE1(2)	2657223	48	30	48	12	14	13	2	11	8	0	0.085	0.99	1.00
75	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(2), COASY(1), DPYD(13), DPYS(2), ENPP1(1), ENPP3(3), PANK1(2), PANK2(2), PANK4(3), UPB1(2)	2757218	31	24	31	7	8	9	1	8	5	0	0.099	0.99	1.00
76	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(13), EP300(15), ESR1(5), MAPK1(2), MAPK3(1), PELP1(6)	2887230	42	26	41	9	11	12	1	5	13	0	0.099	0.99	1.00
77	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), GPR109B(2), GPR161(2), GPR39(6), GPR45(4), GPR68(4), GPR75(5), GPR81(2)	1956733	27	18	27	8	13	5	2	6	1	0	0.18	0.99	1.00
78	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(1), EPHX2(4), HSD3B7(3), RDH11(1), RDH12(1)	948226	10	9	10	4	2	4	0	4	0	0	0.61	1.00	1.00
79	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(4), GBA3(1), GGT1(8), SHMT1(1), SHMT2(4)	1094074	19	17	18	7	7	3	1	5	3	0	0.45	1.00	1.00
80	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CCNH(2), CDC25A(2), CDC25B(4), CDC25C(3), MNAT1(2), XPO1(3)	1711745	17	11	17	3	6	3	1	3	4	0	0.15	1.00	1.00
81	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(4), AKT1(2), ANXA1(3), CALM1(1), CALM2(2), CALM3(1), GNAS(14), GNB1(1), GNGT1(3), NFKB1(5), NOS3(3), NPPA(1), NR3C1(5), PIK3R1(7), RELA(2)	3106554	54	32	53	12	16	17	0	12	9	0	0.11	1.00	1.00
82	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(3), TAT(1)	519281	6	6	6	3	2	2	0	1	1	0	0.77	1.00	1.00
83	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(2), BCAT2(1), COASY(1), DPYD(13), DPYS(2), ENPP1(1), ENPP3(3), ILVBL(3), PANK1(2), PANK2(2), PANK4(3), PPCDC(1), UPB1(2), VNN1(1)	3426026	37	24	37	7	13	10	1	8	5	0	0.029	1.00	1.00
84	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), IL1B(1), MST1(2), MST1R(8), TNF(2)	1290930	14	13	14	4	6	4	0	3	1	0	0.33	1.00	1.00
85	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(4), JUN(2), KEAP1(6), MAPK1(2), MAPK14(1), MAPK8(4), NFE2L2(1)	1735891	20	15	20	6	6	9	0	4	1	0	0.29	1.00	1.00
86	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), CYCS(1), GPD2(3), NDUFA1(1), SDHA(5), SDHB(4), SDHC(1), UQCRC1(2)	1310265	18	14	18	5	6	5	2	3	2	0	0.29	1.00	1.00
87	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(2), IFNGR1(2), JAK1(4), JAK2(8), PTPRU(13), REG1A(4), STAT1(6)	2271344	41	23	41	10	14	10	1	11	4	1	0.17	1.00	1.00
88	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(3), ACAT2(3), HMGCL(1), OXCT1(4)	669444	11	9	11	5	3	6	0	1	1	0	0.74	1.00	1.00
89	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(4), ALOX15(2), ALOX15B(1), ALOX5(6), ALOX5AP(2), DPEP1(1), GGT1(8), LTA4H(4), PLA2G6(3), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(2)	2959416	45	30	44	11	17	11	3	11	3	0	0.094	1.00	1.00
90	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(3), CBS(3), CTH(2), MUT(3)	962808	11	10	11	9	3	3	1	1	3	0	0.98	1.00	1.00
91	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(2), IFNAR1(5), IFNAR2(4), IFNB1(2), MAPK8(4), NFKB1(5), RELA(2), TNFRSF11A(4), TNFSF11(1), TRAF6(4)	2201392	33	19	33	9	8	10	1	9	5	0	0.27	1.00	1.00
92	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(3), ST3GAL1(3), ST3GAL2(4), ST3GAL4(3), ST3GAL5(1), ST6GALNAC2(1), ST6GALNAC4(2), ST8SIA1(4)	1117798	21	20	21	8	10	4	0	7	0	0	0.49	1.00	1.00
93	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(2), GOSR1(2), GOSR2(2), SNAP25(1), SNAP29(3), STX10(3), STX11(2), STX16(3), STX17(1), STX18(2), STX19(3), STX2(1), STX3(1), STX4(1), STX5(2), STX6(3), STX7(1), STX8(1), TSNARE1(7), USE1(2), VAMP4(1), VAMP5(1), VAMP7(2), VTI1B(1), YKT6(1)	3290008	49	28	49	10	19	16	2	10	2	0	0.045	1.00	1.00
94	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(15), CPT1A(4), LEPR(8), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2)	2870839	37	19	37	9	15	8	2	5	7	0	0.15	1.00	1.00
95	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(2), BAD(1), CASP9(1), GH1(3), GHR(5), NFKB1(5), PDPK1(1), PIK3R1(7), PPP2CA(3), RELA(2), YWHAH(1)	2365581	31	17	31	9	6	14	2	4	5	0	0.32	1.00	1.00
96	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX1(2), ACOX3(5), ELOVL2(1), ELOVL5(2), FADS1(2), FADS2(4), FASN(11), HADHA(2), HSD17B12(2), SCD(4)	2800812	36	19	34	9	13	8	1	8	6	0	0.16	1.00	1.00
97	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(6), LCT(11), PGM1(3), PYGL(5), PYGM(7), TPI1(2), TREH(4)	2645520	38	23	38	10	19	10	1	4	4	0	0.14	1.00	1.00
98	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(4), AASS(2), KARS(3)	939489	9	6	9	4	2	5	1	1	0	0	0.70	1.00	1.00
99	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(3), GOT1(2), GOT2(3), TAT(1), TYR(5)	931324	14	14	14	6	3	5	0	4	2	0	0.73	1.00	1.00
100	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(3), GNAS(14), GNB1(1), GNGT1(3), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6)	1891791	36	25	35	10	14	9	1	8	4	0	0.30	1.00	1.00
101	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	CSNK2A1(4), ELK1(2), GRB2(1), JUN(2), MAP2K1(4), MAPK3(1), MAPK8(4), NGFR(5), PIK3R1(7), PLCG1(10), RAF1(6), SHC1(3), SOS1(4)	3340371	53	29	52	14	14	21	1	11	6	0	0.15	1.00	1.00
102	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(3), PSMA6(3), PSMA7(3), PSMB2(1), PSMB3(1), PSMB4(1), PSMC3(6), RPN1(1), RPN2(3), UBE2A(2), UBE3A(5)	2570573	32	18	32	8	7	12	4	5	4	0	0.16	1.00	1.00
103	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(17), CDC25A(2), CDC25B(4), CDC25C(3), CDK2(2), CHEK1(2), MYT1(12), RB1(8), WEE1(1), YWHAH(1)	3343476	52	29	50	10	16	18	3	6	8	1	0.038	1.00	1.00
104	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	AKT1(2), EIF2B5(4), EIF2S1(1), EIF2S2(2), EIF2S3(1), EIF4E(1), EIF4EBP1(1), GSK3B(2), IGF1(2), IGF1R(11), INPPL1(13), PDPK1(1), PIK3R1(7), PPP2CA(3), PTEN(8), RPS6(1), RPS6KB1(3)	3464382	63	38	62	16	19	20	2	10	12	0	0.13	1.00	1.00
105	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(2), HADHA(2), SDS(1)	961259	5	3	4	4	0	3	0	0	2	0	0.88	1.00	1.00
106	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(2), MAX(1), SP1(3), SP3(3), WT1(1)	1225732	10	9	10	7	3	4	0	1	2	0	0.86	1.00	1.00
107	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(4), NR0B2(2), NR1H3(2), NR1H4(3), RXRA(3)	1078636	17	14	17	7	7	3	0	5	2	0	0.54	1.00	1.00
108	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(17), ATR(5), CDC25C(3), CHEK1(2), CHEK2(5), YWHAH(1)	3023760	33	24	32	9	11	11	2	3	5	1	0.45	1.00	1.00
109	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP2(3), ACP5(2), ACP6(3), ACPP(3), ACPT(1), ENPP1(1), ENPP3(3), FLAD1(2), LHPP(3), MTMR1(3), MTMR2(3), MTMR6(4), PHPT1(3), RFK(1), TYR(5)	2957473	40	25	40	10	10	17	2	8	3	0	0.12	1.00	1.00
110	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), ARG1(2), GLS(4), GLUD1(4)	1091327	12	9	12	5	4	4	0	3	1	0	0.59	1.00	1.00
111	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(17), CR2(4), FCGR2B(1), HLA-DRA(3), HLA-DRB1(1), ICAM1(2), ITGAL(7), ITGB2(6), PTPRC(16)	3026176	58	35	56	17	17	17	0	17	5	2	0.19	1.00	1.00
112	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(6), ADC(1), AGMAT(2), ALDH18A1(4), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), AMD1(2), AOC2(4), AOC3(3), ARG1(2), ASL(5), ASS1(6), CPS1(15), GATM(2), MAOA(1), MAOB(3), NAGS(1), ODC1(3), OTC(2), SAT1(1), SMS(2), SRM(1)	5832810	90	42	90	22	25	26	5	27	6	1	0.033	1.00	1.00
113	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(1), NDUFA8(1), NDUFB2(1), NDUFB7(1), NDUFS1(5), NDUFS2(2), NDUFV1(1)	1365674	13	12	13	4	1	5	2	3	2	0	0.54	1.00	1.00
114	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(4), GRB2(1), HBXIP(1), PTK2B(8), SHC1(3), SOS1(4)	1748610	21	14	21	7	5	8	0	3	5	0	0.49	1.00	1.00
115	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(5), PLCB1(12), RELA(2)	1636017	20	15	20	7	6	5	0	5	4	0	0.64	1.00	1.00
116	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(1), ENO3(3), FARS2(7), GOT1(2), GOT2(3), PAH(5), TAT(1), YARS(1)	1645117	26	18	26	9	8	10	0	5	3	0	0.45	1.00	1.00
117	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(2), DHRS3(1), DHRS7(1), DHRSX(2), LCMT1(1), LCMT2(7), METTL6(1), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), WBSCR22(2)	2969307	31	21	31	8	8	11	1	6	5	0	0.16	1.00	1.00
118	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(4), CYP11A1(2), CYP11B2(2), CYP17A1(2), HSD11B1(1), HSD11B2(2), HSD3B1(1), HSD3B2(1)	1371346	15	11	15	5	5	3	1	5	1	0	0.42	1.00	1.00
119	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	ARF1(2), CCND1(1), CDK2(2), CDKN1A(1), CDKN2A(4), CFL1(1), E2F2(2), MDM2(3), NXT1(2), PRB1(2)	1439576	20	18	20	9	6	8	1	2	3	0	0.66	1.00	1.00
120	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(2), ACAD9(2), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), DHRS3(1), DHRS7(1), DHRSX(2), ESCO2(2), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), SH3GLB1(1)	4959740	64	35	63	16	14	24	4	14	8	0	0.066	1.00	1.00
121	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(13), EP300(15), LPL(2), NCOA1(11), NCOA2(12), PPARG(1), RXRA(3)	3665194	57	30	57	14	10	25	3	8	11	0	0.060	1.00	1.00
122	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), EHHADH(2), HADHA(2), SDS(1)	2402157	37	24	36	13	7	10	0	13	7	0	0.47	1.00	1.00
123	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(2), PIK3R1(7), PLCB1(12), PLCG1(10), VAV1(7)	2109183	38	28	37	11	13	12	0	6	7	0	0.33	1.00	1.00
124	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(2), BIRC2(2), BIRC3(4), CASP3(1), CASP8(6), JUN(2), MAP2K4(5), MAP3K3(2), MAP3K7(7), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), NR2C2(3), RALBP1(7), TNF(2), TNFAIP3(5), TNFRSF1A(3), TNFRSF1B(1), TRAF2(2)	5364016	72	31	72	15	24	18	4	16	10	0	0.019	1.00	1.00
125	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACAA2(1), ACADL(2), ACADM(1), ACADS(1), ACADSB(3), ACAT1(3), ACAT2(3), ACOX1(2), ACOX3(5), ACSL1(2), ACSL3(6), ACSL4(3), ACSL5(2), ACSL6(5), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), CPT1A(4), CPT1B(4), CPT1C(4), CPT2(4), CYP4A11(1), CYP4A22(1), EHHADH(2), GCDH(3), HADH(2), HADHA(2), HADHB(2), HSD17B4(2)	9703020	118	45	116	27	23	37	4	31	23	0	0.0078	1.00	1.00
126	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(3), CSF3(1), HLA-DRA(3), HLA-DRB1(1), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL11(2), IL12B(2), IL13(2), IL2(1), IL3(1), IL6(1), IL8(1), LTA(2), PDGFA(1), TGFB1(3), TGFB2(6), TGFB3(4), TNF(2)	2644219	42	32	42	14	9	17	1	13	2	0	0.39	1.00	1.00
127	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(17), CDC25A(2), CDC25B(4), CDC25C(3), CHEK1(2), MYT1(12), WEE1(1), YWHAH(1)	2743585	42	26	41	10	16	14	2	4	5	1	0.12	1.00	1.00
128	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(1), CHST12(6), CHST13(1), PAPSS1(4), PAPSS2(2), SULT1A1(2), SULT1A2(4), SULT1E1(3), SULT2A1(1)	1818696	26	16	26	8	11	10	1	2	2	0	0.28	1.00	1.00
129	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(6), CALCR(4), CALCRL(5), CD97(2), CRHR1(2), CRHR2(3), ELTD1(9), EMR1(10), EMR2(3), GLP1R(1), GLP2R(4), GPR64(6), LPHN1(6), LPHN2(11), LPHN3(11), SCTR(2), VIPR1(4), VIPR2(4)	5281281	93	43	93	24	23	28	6	30	6	0	0.041	1.00	1.00
130	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(3), CDC34(1), CDK2(2), CUL1(10), FBXW7(11), RB1(8), TFDP1(2)	1646571	37	20	34	12	10	12	1	8	6	0	0.32	1.00	1.00
131	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	FH(2), IDH2(1), MDH1(3), OGDH(8), SDHA(5), SUCLA2(3)	1855116	22	18	21	8	8	5	1	4	4	0	0.60	1.00	1.00
132	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(2), IARS(7), LARS(3), LARS2(5), PDHA1(1), PDHA2(4), PDHB(2)	1991199	24	19	24	8	2	7	1	11	3	0	0.61	1.00	1.00
133	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(4), CYP2A6(2), CYP2A7(3), NAT1(1), NAT2(5), XDH(9)	1582599	27	21	26	9	9	13	1	4	0	0	0.29	1.00	1.00
134	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(4), ENO1(3), GPI(4), HK1(6), PFKL(7), PGK1(1), PKLR(4), TPI1(2)	1822060	31	21	31	10	12	13	1	5	0	0	0.20	1.00	1.00
135	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(3), PSMA6(3), PSMA7(3), PSMB10(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB8(2), PSMB9(1)	1729676	19	9	19	7	7	6	2	2	2	0	0.55	1.00	1.00
136	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(4), GRB2(1), JAK2(8), JUN(2), MAP2K1(4), MAPK3(1), PIK3R1(7), PLCG1(10), RAF1(6), SHC1(3), SOS1(4), STAT1(6), STAT3(7), STAT5A(1), STAT5B(4), THPO(2)	5099130	70	33	69	17	17	28	2	13	10	0	0.077	1.00	1.00
137	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAA2(1), ACAT1(3), ACAT2(3), EHHADH(2), HADHA(2), HADHB(2), SDS(1)	1656270	15	9	14	5	1	8	0	2	4	0	0.41	1.00	1.00
138	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(2), ARHGAP5(6), CASP1(2), CASP10(3), CASP3(1), CASP8(6), CASP9(1), CYCS(1), JUN(2), PRF1(1)	2555679	25	17	25	8	5	5	2	8	4	1	0.61	1.00	1.00
139	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(5), ESR2(6), ITPKA(1), PDE1A(3), PDE1B(2), PLCB1(12), PLCB2(4), PRL(2), TRH(3), VIP(1)	2190469	39	27	38	12	12	12	2	8	5	0	0.33	1.00	1.00
140	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(5), NR1I3(3), PTGS1(5), PTGS2(2)	1057946	18	14	18	8	8	6	1	2	1	0	0.67	1.00	1.00
141	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(16), GNA12(1), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAR2A(1), PRKAR2B(6)	1992584	31	23	31	10	7	13	1	7	3	0	0.29	1.00	1.00
142	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(2), CYP11A1(2), CYP11B1(2), CYP11B2(2), CYP17A1(2), CYP21A2(3), HSD11B1(1), HSD11B2(2), HSD3B1(1), HSD3B2(1)	1743048	21	16	21	8	11	5	0	4	1	0	0.45	1.00	1.00
143	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(2), CYP11A1(2), CYP11B1(2), CYP11B2(2), CYP17A1(2), CYP21A2(3), HSD11B1(1), HSD11B2(2), HSD3B1(1), HSD3B2(1)	1743048	21	16	21	8	11	5	0	4	1	0	0.45	1.00	1.00
144	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(4), BAIAP2(3), CASP1(2), CASP3(1), CASP7(2), CASP8(6), GAPDH(1), INSR(10), ITCH(3), MAGI1(16), MAGI2(10), RERE(17), WWP1(8), WWP2(10)	4728947	93	42	92	26	26	21	5	19	22	0	0.16	1.00	1.00
145	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	AKT1(2), BCAR1(4), GRB2(1), ILK(2), ITGB1(4), MAPK1(2), MAPK3(1), PDPK1(1), PIK3R1(7), PTEN(8), PTK2(7), SHC1(3), SOS1(4)	3365598	46	30	45	12	5	18	4	7	12	0	0.21	1.00	1.00
146	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(10), PTK2B(8)	1334888	19	16	18	9	11	3	0	4	1	0	0.77	1.00	1.00
147	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(7), CHAT(1), CHKA(1), PCYT1A(7), PDHA1(1), PDHA2(4), PEMT(1), SLC18A3(6)	1368800	28	19	28	11	14	6	0	8	0	0	0.44	1.00	1.00
148	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(2), BFAR(1), BRAF(5), CAMP(1), CREB1(4), CREB3(3), CREB5(2), MAPK1(2), RAF1(6), SNX13(6), TERF2IP(3)	2246021	35	26	35	10	13	9	0	8	5	0	0.36	1.00	1.00
149	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(20), ASAH1(2), CAMP(1), CASP3(1), CERK(3), CREB1(4), CREB3(3), CREB5(2), CXCL2(1), DAG1(7), EPHB2(11), GNAQ(1), ITPKA(1), ITPKB(6), JUN(2), MAP2K4(5), MAP2K7(13), MAPK1(2), MAPK10(3), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3)	5599881	106	40	102	29	33	27	1	22	21	2	0.091	1.00	1.00
150	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(3), CD8A(2), CSF3(1), IL11(2), IL2(1), IL3(1), IL6(1), IL8(1)	1209585	12	11	12	6	3	4	0	4	1	0	0.79	1.00	1.00
151	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(5), FADS2(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3)	2012502	32	22	32	10	14	5	1	10	2	0	0.40	1.00	1.00
152	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADH(2), HADHA(2), HADHB(2), HSD17B4(2), MECR(3), PPT2(2)	1679667	14	8	13	4	1	5	1	3	4	0	0.33	1.00	1.00
153	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAA2(1), ACAD8(2), ACAD9(2), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), AKR1B10(1), AKR1C4(3), AKR1D1(2), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), BAAT(1), CEL(6), CYP27A1(1), CYP7A1(3), HADHB(2), HSD3B7(3), LIPA(2), RDH11(1), RDH12(1), SLC27A5(6), SOAT1(5), SOAT2(2), SRD5A1(2), SRD5A2(3)	6270702	97	44	96	26	21	33	2	28	13	0	0.065	1.00	1.00
154	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP2(3), ACP5(2), ACPP(3), ACPT(1), ENPP1(1), ENPP3(3), FLAD1(2), RFK(1), TYR(5)	1897954	21	16	21	7	4	8	1	5	3	0	0.48	1.00	1.00
155	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(4), ABP1(6), ACADL(2), ACADM(1), ACADSB(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), AOC2(4), AOC3(3), CNDP1(1), DPYD(13), DPYS(2), EHHADH(2), GAD1(3), GAD2(4), HADHA(2), MLYCD(3), SDS(1), SMS(2), UPB1(2)	5752530	90	42	88	27	23	31	2	23	10	1	0.11	1.00	1.00
156	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(8), EIF2AK4(5), EIF2B5(4), EIF2S1(1), EIF2S2(2), EIF2S3(1), EIF5(3), GSK3B(2), PPP1CA(2)	2288962	28	21	28	9	5	12	1	9	1	0	0.41	1.00	1.00
157	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(2), CDK5R1(1), CSNK1D(2), DRD1(3), DRD2(6), GRM1(17), PLCB1(12), PPP1CA(2), PPP2CA(3), PPP3CA(3), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6)	3166545	66	36	66	22	21	24	0	15	6	0	0.26	1.00	1.00
158	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM1(1), CALM2(2), CALM3(1), CDKN1A(1), GNAQ(1), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), PLCG1(10), PPP3CA(3), PPP3CB(1), SP1(3), SP3(3)	4072564	57	30	56	17	20	24	0	8	5	0	0.11	1.00	1.00
159	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDK2(2), CUL1(10), NEDD8(1), RB1(8), SKP2(4), TFDP1(2)	1709248	30	19	29	11	5	11	1	8	5	0	0.51	1.00	1.00
160	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(4), FUT1(2), FUT9(3), HEXA(1), HEXB(3), NAGA(3), ST3GAL1(3), ST3GAL2(4), ST3GAL4(3), ST8SIA1(4)	2003353	30	24	30	10	12	5	0	12	1	0	0.48	1.00	1.00
161	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3E(3), CD3G(2), ETV5(5), IFNG(2), IL12B(2), IL12RB1(4), IL12RB2(5), IL18R1(2), JAK2(8), JUN(2), MAP2K6(2), MAPK14(1), MAPK8(4), STAT4(4), TYK2(6)	3674289	53	27	52	15	9	19	3	12	10	0	0.23	1.00	1.00
162	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(9), AMT(4), ATIC(5), GART(6), MTHFD1(3), MTHFD1L(2), MTHFD2(1), MTHFR(5), MTR(9), SHMT1(1), SHMT2(4), TYMS(1)	3544578	50	31	50	15	13	16	4	8	9	0	0.17	1.00	1.00
163	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	AKT1(2), CREB1(4), GRB2(1), MAPK1(2), MAPK3(1), MAPK7(8), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), NTRK1(4), PIK3R1(7), PLCG1(10), RPS6KA1(6), SHC1(3)	3301945	60	30	59	15	22	23	1	7	7	0	0.053	1.00	1.00
164	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(4), ABP1(6), ACADM(1), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), AOC2(4), AOC3(3), CNDP1(1), DPYD(13), DPYS(2), EHHADH(2), GAD1(3), GAD2(4), HADHA(2), MLYCD(3), SMS(2), SRM(1), UPB1(2)	5342259	77	39	75	23	21	25	2	20	8	1	0.11	1.00	1.00
165	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(3), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), CYP2C19(6), CYP2C9(1), DHRS3(1), DHRS7(1), DHRSX(2), EHHADH(2), ESCO2(2), HADHA(2), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), SH3GLB1(1), YOD1(2)	6119325	77	37	76	21	20	23	3	22	9	0	0.089	1.00	1.00
166	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(1), SRP19(1), SRP54(2), SRP72(4), SRPR(3)	1491187	12	10	12	5	4	5	0	2	1	0	0.74	1.00	1.00
167	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(5), IFNB1(2), JAK1(4), PTPRU(13), REG1A(4), STAT1(6), STAT2(4), TYK2(6)	2463540	44	26	44	13	17	11	0	11	4	1	0.30	1.00	1.00
168	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	CSNK2A1(4), ELK1(2), GRB2(1), IGF1(2), IGF1R(11), IRS1(7), JUN(2), MAP2K1(4), MAPK3(1), MAPK8(4), PIK3R1(7), PTPN11(4), RAF1(6), SHC1(3), SOS1(4), SRF(1)	4068109	63	32	63	19	15	25	1	15	7	0	0.21	1.00	1.00
169	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(4), ASNS(4), ASRGL1(1), CA1(1), CA12(2), CA13(2), CA14(1), CA2(1), CA3(1), CA4(2), CA5B(1), CA6(3), CA7(2), CA8(1), CA9(2), CPS1(15), CTH(2), GLS(4), GLS2(5), GLUD1(4), GLUD2(7), GLUL(2), HAL(2)	4197941	69	38	69	20	20	18	4	21	6	0	0.19	1.00	1.00
170	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(3), ACAT2(3), BDH1(1), HMGCL(1), HMGCS1(1), HMGCS2(1), OXCT1(4)	1429775	14	12	14	8	4	6	0	3	1	0	0.87	1.00	1.00
171	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ACAA2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), AKR1C4(3), AKR1D1(2), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), BAAT(1), CEL(6), CYP27A1(1), CYP7A1(3), HADHB(2), SOAT2(2), SRD5A1(2), SRD5A2(3)	4596996	81	39	80	25	17	27	0	24	13	0	0.24	1.00	1.00
172	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(4), ADORA2B(1), ADORA3(2), LTB4R(2), P2RY1(5), P2RY2(1), P2RY6(3)	1172555	18	15	18	9	7	4	0	6	1	0	0.74	1.00	1.00
173	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(4), CARS2(2), CTH(2), GOT1(2), GOT2(3), LDHAL6B(2), LDHB(2), LDHC(1), MPST(1), SDS(1), SULT1B1(2), SULT1C4(1), SULT4A1(1)	2456977	24	16	24	8	8	9	1	3	3	0	0.36	1.00	1.00
174	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(1), JUN(2), MAP2K1(4), MAPK1(2), MAPK3(1), NFKB1(5), PLCB1(12), RAF1(6), RELA(2), TNF(2)	3075622	37	24	37	12	10	10	1	11	5	0	0.44	1.00	1.00
175	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(3), GNAQ(1), GNB1(1), GNGT1(3), HTR2C(3), PLCB1(12), TUB(6)	1415903	29	20	29	10	12	7	0	5	5	0	0.48	1.00	1.00
176	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	DNAJC3(1), EIF2S1(1), EIF2S2(2), MAP3K14(3), NFKB1(5), RELA(2)	1786766	14	10	14	5	3	3	0	6	2	0	0.80	1.00	1.00
177	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(4), B3GAT2(1), B3GAT3(2), B4GALT7(1), CHPF(2), CHST11(1), CHST12(6), CHST13(1), CHST3(1), CHST7(1), CHSY1(3), DSE(6), UST(5), XYLT1(7), XYLT2(4)	2700217	45	25	45	12	20	15	2	6	2	0	0.093	1.00	1.00
178	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(6), ACY3(1), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH3B2(4), ALDH9A1(4), AOC2(4), AOC3(3), CARM1(2), CNDP1(1), DDC(3), HAL(2), HARS(4), HARS2(3), HDC(5), HNMT(1), LCMT1(1), LCMT2(7), MAOA(1), MAOB(3), METTL6(1), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), PRPS1(1), PRPS2(3), UROC1(4), WBSCR22(2)	7831637	100	45	99	27	22	29	4	34	10	1	0.067	1.00	1.00
179	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(3), CLOCK(2), CRY1(1), CRY2(2), CSNK1E(6), PER1(4)	1667690	18	12	18	7	5	5	1	5	2	0	0.70	1.00	1.00
180	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS3(1), DHRS7(1), DHRSX(2), ESCO2(2), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), SH3GLB1(1)	3281044	37	26	37	11	11	12	3	8	3	0	0.24	1.00	1.00
181	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(5), EGFR(10), ERBB3(21), NRG1(9)	2021890	45	25	42	15	13	12	1	15	4	0	0.44	1.00	1.00
182	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(16), C5(9), C6(8), C7(2), ICAM1(2), IL6(1), IL8(1), ITGA4(8), ITGAL(7), ITGB1(4), ITGB2(6), SELP(2), SELPLG(6), TNF(2), VCAM1(5)	4933886	79	39	78	24	25	19	2	25	8	0	0.15	1.00	1.00
183	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(9), AMT(4), ATIC(5), GART(6), MTHFD1(3), MTHFD1L(2), MTHFD2(1), MTHFR(5), MTR(9), SHMT1(1), SHMT2(4), TYMS(1)	3743352	50	31	50	16	13	16	4	8	9	0	0.23	1.00	1.00
184	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(2), CREB1(4), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K6(2), MAP3K1(8), MAPK1(2), MAPK14(1), MAPK3(1), NFKB1(5), PIK3R1(7), RB1(8), RELA(2), SP1(3)	3414003	51	26	50	13	9	22	1	9	10	0	0.15	1.00	1.00
185	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(5), AGT(2), AGTR1(1), AGTR2(1), COL4A1(13), COL4A2(7), COL4A3(4), COL4A4(7), COL4A5(5), COL4A6(7), REN(3)	5039420	55	32	55	19	13	23	1	15	3	0	0.27	1.00	1.00
186	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(8), APOBEC1(3), APOBEC3A(1), APOBEC3B(3), APOBEC3G(2), APOBEC4(1)	1453284	18	14	18	7	8	3	2	4	1	0	0.64	1.00	1.00
187	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(9), ACSS1(7), ACSS2(3), FH(2), IDH1(1), IDH2(1), MDH1(3), MDH2(1), SUCLA2(3)	2635325	32	21	31	11	10	6	4	7	5	0	0.42	1.00	1.00
188	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), HMOX1(3), IL10(1), IL10RA(2), IL10RB(1), IL6(1), JAK1(4), STAT1(6), STAT3(7), STAT5A(1), TNF(2)	2417612	30	19	30	10	5	15	0	8	1	1	0.36	1.00	1.00
189	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), MDH1(3), ME1(3), PC(6), PDHA1(1), SLC25A1(2)	1829312	17	12	17	8	8	2	3	3	1	0	0.71	1.00	1.00
190	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	IKBKB(3), IL1R1(3), IRAK1(5), MAP3K1(8), MAP3K14(3), MAP3K7(7), MYD88(2), NFKB1(5), RELA(2), TNF(2), TNFAIP3(5), TNFRSF1A(3), TNFRSF1B(1), TRAF6(4)	4461061	53	28	53	15	19	13	4	10	7	0	0.18	1.00	1.00
191	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK1(6), HK2(6), HK3(3), IMPA1(3), PGM1(3), PGM3(6), TGDS(2)	2022812	32	19	32	11	13	13	3	1	2	0	0.22	1.00	1.00
192	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(3), CYB5R3(1), GCK(3), GFPT1(3), GNE(3), GNPDA1(3), GNPDA2(1), HEXA(1), HEXB(3), HK1(6), HK2(6), HK3(3), PGM3(6), RENBP(2)	3346301	44	26	44	12	20	12	4	6	2	0	0.11	1.00	1.00
193	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(5), GUSB(3), UCHL1(2), UCHL3(3), UGDH(4), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2B15(1), UGT2B4(2)	3479638	25	16	25	9	7	11	0	3	4	0	0.46	1.00	1.00
194	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(4), ARG1(2), ASL(5), CKB(1), CKMT1A(2), CKMT1B(3), CKMT2(6), CPS1(15), GATM(2), GLUD1(4), NAGS(1), ODC1(3), OTC(2), PYCR1(2), SMS(2)	3449399	54	31	54	16	23	13	3	14	1	0	0.19	1.00	1.00
195	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRA2A(2), ADRA2C(3), ADRB1(3), ADRB2(4), ADRB3(1), CHRM1(3), CHRM2(7), CHRM3(6), CHRM4(2), CHRM5(3), DRD1(3), DRD2(6), DRD3(8), DRD4(1), DRD5(10), HRH1(3), HRH2(4), HTR1A(6), HTR1B(5), HTR1D(4), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(5), HTR2C(3), HTR4(4), HTR5A(4), HTR6(1), HTR7(4)	5062052	125	44	121	38	51	32	7	27	8	0	0.025	1.00	1.00
196	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(15), ACACB(13), FASN(11), MCAT(1), OXSM(3)	3095404	43	21	42	13	14	11	1	7	10	0	0.26	1.00	1.00
197	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	CSNK2A1(4), ELK1(2), GRB2(1), INSR(10), IRS1(7), JUN(2), MAP2K1(4), MAPK3(1), MAPK8(4), PIK3R1(7), PTPN11(4), RAF1(6), SHC1(3), SLC2A4(1), SOS1(4), SRF(1)	4203136	61	32	61	19	16	23	1	12	9	0	0.20	1.00	1.00
198	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(8), AP2A1(1), AP2M1(7), CALM1(1), CALM2(2), CALM3(1), DNM1(5), EPN1(4), PICALM(1), PPP3CA(3), PPP3CB(1), SYNJ1(7), SYNJ2(15)	4276223	56	28	52	16	22	9	2	15	8	0	0.23	1.00	1.00
199	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(3), GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(2), HDAC3(4), NCOA1(11), NCOA2(12), NCOA3(7), NCOR2(15), POLR2A(9), RARA(2), RXRA(3), TBP(3)	4922630	79	39	79	27	21	31	2	18	7	0	0.24	1.00	1.00
200	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(3), ACAT2(3), ACOT11(3), ACYP2(1), DHRS3(1), DHRS7(1), DHRSX(2), EHHADH(2), ESCO2(2), FN3K(2), GCDH(3), HADHA(2), ITGB1BP3(3), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), SH3GLB1(1), YOD1(2)	5147020	61	32	60	17	16	25	4	9	7	0	0.069	1.00	1.00
201	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), EIF4E(1), FBL(2), GPT(1), LDHB(2), LDHC(1), MAPK14(1), NCL(7)	1752576	18	13	18	8	6	5	0	6	1	0	0.75	1.00	1.00
202	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG1(2), ASL(5), ASS1(6), CKB(1), CKMT1A(2), CKMT1B(3), CKMT2(6), CPS1(15), DAO(5), EPRS(6), GATM(2), GLUD1(4), GLUD2(7), GOT1(2), GOT2(3), LAP3(1), NOS1(16), NOS3(3), OTC(2), P4HA1(1), P4HA2(6), P4HA3(1), PARS2(1), PYCR1(2), PYCR2(1), PYCRL(1), RARS(2), RARS2(2)	7087433	110	50	109	29	38	29	5	29	9	0	0.052	1.00	1.00
203	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(2), HSPA1A(1), IFNG(2), IFNGR1(2), IFNGR2(1), IKBKB(3), JAK2(8), LIN7A(6), NFKB1(5), RB1(8), RELA(2), TNF(2), TNFRSF1A(3), TNFRSF1B(1), USH1C(1), WT1(1)	3437327	48	27	46	16	9	14	1	14	10	0	0.47	1.00	1.00
204	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(4), CREM(1), JUN(2), MAPK3(1), OPRK1(4), POLR2A(9), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6)	2541511	36	23	36	13	10	14	0	8	4	0	0.37	1.00	1.00
205	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(4), EPX(4), LPO(2), MPO(5), MTHFR(5), PRDX6(1), SHMT1(1), SHMT2(4), TPO(13)	2297007	40	27	40	13	13	7	3	11	6	0	0.41	1.00	1.00
206	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(2), ARFGAP1(1), ARFGAP3(4), ARFGEF2(14), CLTA(2), COPA(4), GBF1(8), GPLD1(9), KDELR1(1)	3203218	45	26	45	14	13	21	1	9	1	0	0.18	1.00	1.00
207	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(2), CALM1(1), CALM2(2), CALM3(1), ELK1(2), FCER1A(1), GRB2(1), JUN(2), LYN(4), MAP2K1(4), MAP2K4(5), MAP2K7(13), MAP3K1(8), MAPK1(2), MAPK3(1), MAPK8(4), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), PAK2(5), PIK3R1(7), PLA2G4A(3), PLCG1(10), PPP3CA(3), PPP3CB(1), RAF1(6), SHC1(3), SOS1(4), SYK(3), VAV1(7)	8055020	136	47	135	32	40	49	2	23	22	0	0.0041	1.00	1.00
208	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(2), BIRC2(2), BIRC3(4), CASP1(2), CASP10(3), CASP2(3), CASP3(1), CASP4(2), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), DFFA(2), DFFB(2), LMNA(5), LMNB1(2), LMNB2(3), PRF1(1)	3811870	45	27	45	12	14	14	4	9	4	0	0.22	1.00	1.00
209	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(1), DHRS3(1), DHRS7(1), DHRSX(2), HSD3B7(3), PON1(1), PON2(2), RDH11(1), RDH12(1)	1780250	13	13	13	9	4	4	1	3	1	0	0.94	1.00	1.00
210	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), BCL2(1), CASP8(6), CYCS(1), MAP2K1(4), MAP2K4(5), MAP3K1(8), MAPK1(2), MAPK3(1), MAPK8(4), NFKB1(5), NSMAF(9), RAF1(6), RELA(2), SMPD1(4), TNFRSF1A(3), TRAF2(2)	4050604	64	29	64	20	20	19	2	13	10	0	0.23	1.00	1.00
211	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSR(4), GSS(1), IL8(1), NFKB1(5), NOX1(4), RELA(2), TNF(2), XDH(9)	1983346	29	18	29	10	5	13	1	7	3	0	0.43	1.00	1.00
212	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(3), GPLD1(9), PGAP1(4), PIGA(2), PIGB(4), PIGC(2), PIGG(5), PIGK(1), PIGL(1), PIGM(4), PIGN(3), PIGO(1), PIGQ(2), PIGS(1), PIGT(3), PIGV(3), PIGX(2), PIGZ(2)	4747955	52	28	52	16	16	21	3	6	5	1	0.12	1.00	1.00
213	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2G(4), CAMK4(4), CAMKK1(4), CAMKK2(1), CREB1(4)	2277358	28	17	28	10	7	12	1	5	3	0	0.45	1.00	1.00
214	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(2), BIRC2(2), BIRC3(4), CASP10(3), CASP3(1), CASP7(2), CASP8(6), CASP9(1), DFFA(2), DFFB(2), PRF1(1), SCAP(7), SREBF1(4), SREBF2(7)	3572783	44	30	44	13	13	14	3	9	5	0	0.33	1.00	1.00
215	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(4), ASNS(4), CA1(1), CA12(2), CA14(1), CA2(1), CA3(1), CA4(2), CA5B(1), CA6(3), CA7(2), CA8(1), CA9(2), CPS1(15), CTH(2), GLS(4), GLS2(5), GLUD1(4), GLUL(2), HAL(2)	3755719	59	33	59	19	15	17	4	17	6	0	0.34	1.00	1.00
216	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(4), JAK2(8), JAK3(3), PIAS1(3), PIAS3(1), PTPRU(13), REG1A(4), SOAT1(5)	2726935	43	25	43	13	13	11	0	12	6	1	0.44	1.00	1.00
217	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(10), AKT1(2), ATM(17), CDKN1A(1), CPB2(4), CSNK1D(2), FHL2(2), HIC1(1), HIF1A(2), HSPA1A(1), IGFBP3(4), MAPK8(4), MDM2(3), NFKBIB(4), NQO1(3)	3953191	60	37	59	19	19	20	2	9	9	1	0.23	1.00	1.00
218	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(3), CLOCK(2), CRY1(1), CRY2(2), CSNK1D(2), CSNK1E(6), NPAS2(5), NR1D1(3), PER1(4), PER2(10), PER3(7)	3357480	45	22	45	14	13	14	3	10	5	0	0.30	1.00	1.00
219	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDPS(4), HMGCR(5), LSS(5), MVD(2), MVK(4), NQO1(3), NQO2(3), SC5DL(1), SQLE(4), VKORC1(1)	2191139	34	21	34	12	13	9	1	9	2	0	0.45	1.00	1.00
220	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(2), ESR1(5), GREB1(12), HSPB1(1), HSPB2(1), MTA1(6), PDZK1(2), TUBA8(3)	2159489	32	22	32	13	10	12	1	4	5	0	0.54	1.00	1.00
221	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(2), DLG4(5), EPHB2(11), F2(4), F2RL1(3), F2RL2(1), JUN(2), MAP2K5(1), MAPK1(2), MAPK7(8), MAPK8(4), MYEF2(4), PLD1(7), PLD2(11), PLD3(5), PTK2(7), RAF1(6), RASAL1(1), TEC(3), VAV1(7)	5409910	94	40	91	28	28	31	4	19	12	0	0.16	1.00	1.00
222	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	IFNG(2), IKBKB(3), IL2(1), JUN(2), MAP3K1(8), MAP3K5(3), MAP4K5(4), MAPK14(1), MAPK8(4), NFKB1(5), RELA(2), TNFRSF9(3), TRAF2(2)	3858434	40	21	39	12	15	7	2	10	6	0	0.37	1.00	1.00
223	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(6), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH3B2(4), ALDH9A1(4), AOC2(4), AOC3(3), CNDP1(1), DDC(3), HAL(2), HARS(4), HDC(5), HNMT(1), MAOA(1), MAOB(3), PRPS1(1), PRPS2(3)	4839432	73	38	72	24	17	20	3	26	6	1	0.33	1.00	1.00
224	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2E2(2), GTF2F1(2), GTF2F2(2), GTF2H1(1), GTF2H3(1), GTF2I(4), GTF2IRD1(9), TAF1(5), TAF10(1), TAF13(1), TAF1L(11), TAF2(5), TAF4(3), TAF4B(2), TAF5(2), TAF5L(4), TAF6(7), TAF6L(1), TAF7(4), TAF7L(3), TAF9B(2), TBPL2(3)	7152812	83	38	80	23	26	28	3	16	10	0	0.094	1.00	1.00
225	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(5), IFNAR2(4), IFNB1(2), JAK1(4), STAT1(6), STAT2(4), TYK2(6)	2143249	32	18	32	11	9	11	0	7	4	1	0.47	1.00	1.00
226	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(4), ELK1(2), EPOR(2), GRB2(1), JAK2(8), JUN(2), MAP2K1(4), MAPK3(1), MAPK8(4), PLCG1(10), PTPN6(3), RAF1(6), SHC1(3), SOS1(4), STAT5A(1), STAT5B(4)	4249380	59	28	58	18	15	23	1	13	7	0	0.27	1.00	1.00
227	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(3), PSMA6(3), PSMA7(3), PSMB2(1), PSMB3(1), PSMB4(1), PSMC2(3), PSMC3(6), PSMD1(4), PSMD11(1), PSMD12(1), PSMD2(10), PSMD6(1)	3157005	41	21	41	11	12	15	2	9	3	0	0.23	1.00	1.00
228	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(3), G6PD(2), GCLM(2), GGT1(8), GPX1(1), GPX3(1), GPX4(3), GPX6(2), GPX7(3), GSR(4), GSS(1), GSTA1(2), GSTA2(1), GSTA4(1), GSTA5(1), GSTM1(1), GSTM3(1), GSTM4(1), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(3), IDH1(1), IDH2(1), MGST1(2), MGST2(1), MGST3(1), OPLAH(5), TXNDC12(1)	4295304	58	30	57	19	20	17	2	16	3	0	0.28	1.00	1.00
229	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(4), ANKRD1(2), DUSP14(1), EIF4E(1), EIF4EBP1(1), IFNG(2), IFRD1(2), IL1R1(3), NR4A3(1), WDR1(1)	2117610	18	12	18	9	5	4	4	4	1	0	0.77	1.00	1.00
230	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(2), ABP1(6), AOC2(4), AOC3(3), CES1(7), CES7(7), DDHD1(7), ESCO2(2), LIPA(2), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), PRDX6(1), SH3GLB1(1)	5032944	72	35	71	22	20	26	4	18	3	1	0.18	1.00	1.00
231	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	COPS5(3), CREB1(4), EDN1(3), EP300(15), HIF1A(2), JUN(2), NOS3(3), P4HB(4)	3351533	36	23	36	12	11	10	2	7	6	0	0.38	1.00	1.00
232	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(3), GHR(5), GRB2(1), INSR(10), IRS1(7), JAK2(8), MAP2K1(4), MAPK1(2), MAPK3(1), PIK3R1(7), PLCG1(10), PTPN6(3), RAF1(6), RPS6KA1(6), SHC1(3), SLC2A4(1), SOCS1(1), SOS1(4), SRF(1), STAT5A(1), STAT5B(4)	6105138	88	39	87	25	27	33	2	14	12	0	0.080	1.00	1.00
233	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(7), CHAT(1), COMT(3), DBH(2), DDC(3), GAD1(3), GAD2(4), HDC(5), MAOA(1), PAH(5), PNMT(3), SLC18A3(6), TH(1), TPH1(1)	2830261	46	26	46	18	17	13	2	12	2	0	0.43	1.00	1.00
234	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(9), DLD(2), DLST(1), FH(2), IDH1(1), IDH2(1), IDH3A(1), IDH3B(3), IDH3G(2), MDH1(3), MDH2(1), PC(6), PCK1(4), SDHA(5), SDHB(4), SUCLA2(3), SUCLG1(2), SUCLG2(4)	4068735	54	29	53	18	23	11	2	13	5	0	0.29	1.00	1.00
235	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(13), DUSP1(1), EP300(15), IKBKB(3), IL1B(1), IL8(1), MAP2K3(1), MAP2K6(2), MAP3K14(3), MAP3K7(7), MAPK11(1), MAPK14(1), MYD88(2), NFKB1(5), NR3C1(5), RELA(2), TGFBR1(2), TGFBR2(6), TLR2(3), TNF(2)	5856775	76	38	76	24	16	23	4	18	15	0	0.36	1.00	1.00
236	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNA1(1), IFNB1(2), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(3), IL6(1), IRAK1(5), IRAK2(4), IRAK3(2), JUN(2), MAP2K3(1), MAP2K6(2), MAP3K1(8), MAP3K14(3), MAP3K7(7), MAPK14(1), MAPK8(4), MYD88(2), NFKB1(5), RELA(2), TGFB1(3), TGFB2(6), TGFB3(4), TNF(2), TOLLIP(1), TRAF6(4)	5857347	82	38	81	25	21	23	4	25	9	0	0.31	1.00	1.00
237	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(10), ABCB11(6), ABCB4(13), ABCC1(4), ABCC3(6), GSTP1(1)	2848513	40	25	40	15	10	15	1	8	6	0	0.50	1.00	1.00
238	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(2), BCL2(1), BCR(7), GRB2(1), JAK2(8), JUN(2), MAP2K1(4), MAP2K4(5), MAP3K1(8), MAPK3(1), MAPK8(4), PIK3R1(7), RAF1(6), SOS1(4), STAT1(6), STAT5A(1), STAT5B(4)	5122165	71	32	71	23	17	28	1	11	14	0	0.25	1.00	1.00
239	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(2), GRB2(1), NTRK1(4), PIK3R1(7), PLCG1(10), SHC1(3), SOS1(4)	2642693	31	21	30	10	8	14	0	4	5	0	0.41	1.00	1.00
240	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(8), CALM1(1), CALM2(2), CALM3(1), CAPN2(4), CAPNS1(1), CAPNS2(1), EP300(15), HDAC1(2), HDAC2(4), MEF2D(6), NFATC1(9), NFATC2(8), PPP3CA(3), PPP3CB(1)	4814967	66	27	66	20	24	21	0	12	9	0	0.13	1.00	1.00
241	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(3), CHIA(2), CHIT1(2), CMAS(3), CTBS(2), CYB5R1(1), CYB5R3(1), GFPT1(3), GFPT2(3), GNE(3), GNPDA1(3), GNPDA2(1), HEXA(1), HEXB(3), HK1(6), HK2(6), HK3(3), LHPP(3), MTMR1(3), MTMR2(3), MTMR6(4), NAGK(1), NANS(1), NPL(1), PGM3(6), PHPT1(3), RENBP(2)	5660317	73	33	73	23	28	24	5	14	2	0	0.14	1.00	1.00
242	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(2), APAF1(2), ATM(17), BAD(1), BCL2(1), BID(1), CASP3(1), CASP6(1), CASP7(2), CASP9(1), CYCS(1), EIF2S1(1), PTK2(7), PXN(2), STAT1(6), TLN1(13)	5267991	59	32	58	16	22	19	5	6	6	1	0.11	1.00	1.00
243	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM2(2), CALM3(1), DLG4(5), GRIN1(4), GRIN2A(7), GRIN2B(13), GRIN2C(4), GRIN2D(1), NOS1(16), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6)	5038985	73	36	73	27	26	26	1	12	8	0	0.38	1.00	1.00
244	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(3), DHCR7(2), FDPS(4), HMGCR(5), HMGCS1(1), LSS(5), MVD(2), MVK(4), NSDHL(3), SC4MOL(2), SC5DL(1), SQLE(4)	2612233	36	20	36	13	13	8	2	11	2	0	0.53	1.00	1.00
245	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(4), ACACA(15), ACADL(2), ACADM(1), ACADSB(3), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH6A1(1), ALDH9A1(4), EHHADH(2), HADHA(2), LDHB(2), LDHC(1), MCEE(3), MLYCD(3), MUT(3), PCCA(7), PCCB(2), SDS(1), SUCLA2(3), SUCLG1(2), SUCLG2(4)	6540273	99	37	95	29	26	32	0	21	20	0	0.17	1.00	1.00
246	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(2), BAD(1), GRB2(1), IGF1R(11), IRS1(7), MAP2K1(4), MAPK1(2), MAPK3(1), PIK3R1(7), RAF1(6), SHC1(3), SOS1(4), YWHAH(1)	3319900	50	26	50	17	10	24	1	8	7	0	0.38	1.00	1.00
247	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPAT6(2), AGPS(3), CHPT1(1), ENPP2(3), ENPP6(2), PAFAH1B1(3), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLD1(7), PLD2(11), PPAP2C(5)	4600941	70	31	70	23	21	25	3	13	8	0	0.24	1.00	1.00
248	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREB1(4), CREBBP(13), EP300(15), NCOA3(7), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RARA(2), RXRA(3)	4082329	61	32	61	22	14	24	2	8	13	0	0.35	1.00	1.00
249	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(5), ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), FPGT(3), GCK(3), GMDS(2), GMPPA(4), HK1(6), HK2(6), HK3(3), PFKFB3(2), PFKFB4(1), PFKM(3), PFKP(8), PMM1(1), PMM2(1), TPI1(2)	4749720	61	27	61	20	30	17	2	9	3	0	0.15	1.00	1.00
250	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(6), ALDH1A3(6), ALDH3A1(5), ALDH3B2(4), AOC2(4), AOC3(3), DDC(3), EPX(4), GOT1(2), GOT2(3), HPD(1), LPO(2), MAOA(1), MAOB(3), MPO(5), PRDX6(1), TAT(1), TPO(13)	4342043	67	36	67	23	19	16	1	24	6	1	0.44	1.00	1.00
251	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(13), COL4A2(7), COL4A3(4), COL4A4(7), COL4A5(5), COL4A6(7), P4HB(4), SLC23A1(6), SLC23A2(7), SLC2A1(3), SLC2A3(2)	5002789	65	30	65	28	18	25	0	15	7	0	0.58	1.00	1.00
252	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	232	ADCYAP1R1(6), ADORA1(4), ADORA2B(1), ADORA3(2), ADRA1A(7), ADRA1B(3), ADRA2A(2), ADRA2B(2), ADRA2C(3), ADRB1(3), ADRB2(4), ADRB3(1), AGTR1(1), AGTR2(1), AVPR1A(7), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(3), C3AR1(2), C5AR1(1), CALCR(4), CALCRL(5), CCKAR(2), CCKBR(4), CHRM1(3), CHRM2(7), CHRM3(6), CHRM4(2), CHRM5(3), CNR1(5), CRHR1(2), CRHR2(3), CTSG(3), CYSLTR1(2), DRD1(3), DRD2(6), DRD3(8), DRD4(1), DRD5(10), EDNRA(3), F2(4), F2R(2), F2RL1(3), F2RL2(1), FPR1(1), FSHB(2), GABBR1(8), GABBR2(5), GABRA1(5), GABRA2(5), GABRA3(5), GABRA4(4), GABRA5(5), GABRA6(5), GABRB1(2), GABRB2(4), GABRB3(6), GABRE(4), GABRG1(1), GABRG2(9), GABRG3(2), GABRP(4), GABRQ(7), GABRR1(6), GABRR2(5), GALR1(3), GALR2(1), GALR3(1), GH1(3), GH2(3), GHR(5), GHSR(4), GLP1R(1), GLP2R(4), GLRA1(2), GLRA2(1), GLRA3(2), GLRB(5), GNRHR(3), GPR156(2), GPR35(3), GPR50(5), GPR83(5), GRIA1(11), GRIA2(13), GRIA3(6), GRIA4(3), GRID1(15), GRID2(11), GRIK1(6), GRIK2(11), GRIK3(8), GRIK4(8), GRIK5(5), GRIN1(4), GRIN2A(7), GRIN2B(13), GRIN2C(4), GRIN2D(1), GRIN3A(6), GRIN3B(2), GRM1(17), GRM2(11), GRM3(5), GRM4(5), GRM5(14), GRM6(8), GRM7(12), GRM8(11), GRPR(3), GZMA(2), HCRTR1(3), HCRTR2(2), HRH1(3), HRH2(4), HRH3(3), HRH4(1), HTR1A(6), HTR1B(5), HTR1D(4), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(5), HTR2C(3), HTR4(4), HTR5A(4), HTR6(1), HTR7(4), LEPR(8), LHB(1), LTB4R(2), LTB4R2(3), MAS1(2), MC2R(2), MC3R(3), MC4R(4), MC5R(6), MCHR1(4), MCHR2(3), MLNR(2), MTNR1A(3), MTNR1B(2), NMBR(1), NMUR1(2), NMUR2(1), NPBWR1(8), NPBWR2(5), NPFFR1(1), NPFFR2(4), NPY1R(2), NPY2R(1), NPY5R(1), NR3C1(5), NTSR1(4), OPRD1(3), OPRK1(4), OPRL1(2), OXTR(4), P2RX1(1), P2RX2(5), P2RX3(2), P2RX4(1), P2RX5(2), P2RY1(5), P2RY10(3), P2RY13(4), P2RY14(2), P2RY2(1), P2RY4(2), P2RY6(3), P2RY8(6), PARD3(8), PPYR1(7), PRL(2), PRLHR(2), PRLR(2), PRSS1(3), PRSS3(2), PTAFR(2), PTGDR(5), PTGER2(2), PTGER3(2), PTGER4(1), PTGFR(3), PTH2R(4), RXFP1(5), RXFP2(6), SCTR(2), SSTR1(10), SSTR2(2), SSTR3(4), SSTR4(8), SSTR5(2), TAAR1(3), TAAR2(2), TAAR5(3), TAAR6(5), TACR1(3), TACR2(2), TACR3(6), TBXA2R(7), THRA(4), THRB(5), TRHR(6), TRPV1(6), TSHB(1), TSHR(8), UTS2R(1), VIPR1(4), VIPR2(4)	42950337	862	114	852	258	313	254	32	208	55	0	5.83e-07	1.00	1.00
253	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	190	ACTB(4), ACTG1(2), ACTN1(3), ACTN2(15), ACTN3(2), ACTN4(1), AKT1(2), AKT2(2), AKT3(3), ARHGAP5(6), BAD(1), BCAR1(4), BCL2(1), BIRC2(2), BIRC3(4), BRAF(5), CAPN2(4), CAV1(2), CCND1(1), CCND2(1), CCND3(2), CDC42(1), CHAD(4), COL11A1(15), COL11A2(8), COL1A1(7), COL1A2(17), COL2A1(8), COL3A1(8), COL4A1(13), COL4A2(7), COL4A4(7), COL4A6(7), COL5A1(14), COL5A2(6), COL5A3(5), COL6A1(7), COL6A2(8), COL6A3(21), COL6A6(20), COMP(3), CRK(1), CTNNB1(11), DIAPH1(4), DOCK1(12), EGF(5), EGFR(10), ELK1(2), ERBB2(6), FARP2(4), FLNA(11), FLNB(6), FLNC(21), FLT1(6), FN1(21), FYN(5), GRB2(1), GRLF1(8), GSK3B(2), HGF(11), IBSP(2), IGF1(2), IGF1R(11), ILK(2), ITGA1(4), ITGA10(6), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGA7(5), ITGA8(5), ITGA9(9), ITGAV(4), ITGB1(4), ITGB3(5), ITGB4(12), ITGB5(3), ITGB6(1), ITGB7(3), ITGB8(7), JUN(2), KDR(7), LAMA1(22), LAMA2(18), LAMA3(10), LAMA4(11), LAMA5(14), LAMB1(9), LAMB2(12), LAMB3(13), LAMB4(9), LAMC1(7), LAMC2(8), LAMC3(11), MAP2K1(4), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK9(3), MET(4), MYL2(1), MYL7(1), MYLK(9), MYLK2(3), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PARVA(1), PARVB(3), PARVG(2), PDGFA(1), PDGFB(3), PDGFC(3), PDGFD(3), PDGFRA(4), PDGFRB(8), PDPK1(1), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PIP5K1C(6), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R12A(1), PRKCG(4), PTEN(8), PTK2(7), PXN(2), RAC2(1), RAC3(1), RAF1(6), RAP1A(2), RAP1B(4), RAPGEF1(6), RELN(21), ROCK1(7), ROCK2(3), SHC1(3), SHC2(2), SHC3(4), SHC4(1), SOS1(4), SOS2(5), SPP1(1), THBS1(9), THBS2(7), THBS3(4), THBS4(4), TLN1(13), TLN2(22), TNC(13), TNN(12), TNR(13), TNXB(26), VASP(3), VAV1(7), VAV2(8), VAV3(6), VCL(2), VEGFC(3), VTN(4), VWF(13), ZYX(2)	73016504	1076	111	1066	463	363	351	31	217	111	3	0.82	1.00	1.00
254	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ABI2(3), ACTN1(3), ACTN2(15), ACTN3(2), ACTN4(1), APC(20), APC2(6), ARAF(6), ARHGEF1(2), ARHGEF12(6), ARHGEF4(4), ARHGEF6(10), ARHGEF7(9), ARPC1A(3), ARPC1B(1), ARPC4(1), BAIAP2(3), BCAR1(4), BDKRB1(1), BDKRB2(3), BRAF(5), CD14(1), CDC42(1), CFL1(1), CHRM1(3), CHRM2(7), CHRM3(6), CHRM4(2), CHRM5(3), CRK(1), CSK(3), CYFIP1(5), CYFIP2(9), DIAPH1(4), DIAPH2(3), DIAPH3(14), DOCK1(12), EGF(5), EGFR(10), F2(4), F2R(2), FGD1(5), FGD3(8), FGF1(2), FGF10(4), FGF11(1), FGF12(4), FGF13(4), FGF14(4), FGF17(2), FGF18(2), FGF2(2), FGF20(1), FGF21(1), FGF23(1), FGF5(1), FGF6(5), FGF7(1), FGF9(5), FGFR1(8), FGFR2(5), FGFR3(1), FGFR4(6), FN1(21), GIT1(2), GNA12(1), GNG12(1), GRLF1(8), GSN(5), IQGAP1(5), IQGAP2(9), IQGAP3(10), ITGA1(4), ITGA10(6), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGA7(5), ITGA8(5), ITGA9(9), ITGAD(6), ITGAE(4), ITGAL(7), ITGAM(5), ITGAV(4), ITGAX(6), ITGB1(4), ITGB2(6), ITGB3(5), ITGB4(12), ITGB5(3), ITGB6(1), ITGB7(3), ITGB8(7), LIMK1(4), LIMK2(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MOS(3), MSN(3), MYH10(16), MYH14(11), MYH9(13), MYL2(1), MYL7(1), MYLK(9), MYLK2(3), NCKAP1(6), NCKAP1L(7), NRAS(1), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PDGFA(1), PDGFB(3), PDGFRA(4), PDGFRB(8), PFN2(2), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1C(6), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R12A(1), PPP1R12B(7), PTK2(7), PXN(2), RAC2(1), RAC3(1), RAF1(6), RDX(2), ROCK1(7), ROCK2(3), RRAS(3), RRAS2(1), SCIN(3), SLC9A1(6), SOS1(4), SOS2(5), SSH1(6), SSH2(13), SSH3(5), TIAM1(15), TIAM2(18), TMSL3(1), VAV1(7), VAV2(8), VAV3(6), VCL(2), WASF1(4), WASF2(2), WASL(1)	54061636	816	108	806	324	288	240	24	165	97	2	0.60	1.00	1.00
255	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	166	ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY7(10), ADCY8(12), ADCY9(6), ADORA2B(1), ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRB1(3), ADRB2(4), ADRB3(1), AGTR1(1), ATP2A1(3), ATP2A2(4), ATP2A3(4), ATP2B1(8), ATP2B2(9), ATP2B3(10), ATP2B4(2), AVPR1A(7), AVPR1B(1), BDKRB1(1), BDKRB2(3), CACNA1A(11), CACNA1B(14), CACNA1C(23), CACNA1D(15), CACNA1E(26), CACNA1F(2), CACNA1G(11), CACNA1H(11), CACNA1I(14), CACNA1S(10), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CAMK4(4), CCKAR(2), CCKBR(4), CD38(2), CHRM1(3), CHRM2(7), CHRM3(6), CHRM5(3), CHRNA7(1), CYSLTR1(2), DRD1(3), EDNRA(3), EGFR(10), ERBB2(6), ERBB3(21), ERBB4(18), F2R(2), GNA11(4), GNA14(2), GNA15(2), GNAQ(1), GNAS(14), GRIN1(4), GRIN2A(7), GRIN2C(4), GRIN2D(1), GRM1(17), GRM5(14), GRPR(3), HRH1(3), HRH2(4), HTR2A(2), HTR2B(5), HTR2C(3), HTR4(4), HTR5A(4), HTR6(1), HTR7(4), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), LTB4R2(3), MYLK(9), MYLK2(3), NOS1(16), NOS3(3), NTSR1(4), OXTR(4), P2RX1(1), P2RX2(5), P2RX3(2), P2RX4(1), P2RX5(2), PDE1A(3), PDE1B(2), PDE1C(3), PDGFRA(4), PDGFRB(8), PHKA1(5), PHKA2(7), PHKB(3), PHKG1(2), PHKG2(3), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLCD1(1), PLCD3(6), PLCE1(9), PLCG1(10), PLCG2(6), PLCZ1(2), PPID(3), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), PTAFR(2), PTGER3(2), PTGFR(3), PTK2B(8), RYR1(33), RYR2(43), RYR3(40), SLC25A4(2), SLC25A5(2), SLC25A6(4), SLC8A1(6), SLC8A2(3), SLC8A3(5), SPHK1(5), TACR1(3), TACR2(2), TACR3(6), TBXA2R(7), TNNC1(3), TNNC2(1), TRHR(6), TRPC1(2), VDAC1(2), VDAC3(1)	53004829	905	106	891	318	348	285	39	157	74	2	0.0024	1.00	1.00
256	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRB1(3), ADRB2(4), ADRB3(1), ANXA6(2), ARRB1(3), ARRB2(3), ATP1A4(10), ATP1B3(2), ATP2A2(4), ATP2A3(4), ATP2B1(8), ATP2B2(9), ATP2B3(10), CACNA1A(11), CACNA1B(14), CACNA1C(23), CACNA1D(15), CACNA1E(26), CACNA1S(10), CACNB1(1), CALM1(1), CALM2(2), CALM3(1), CALR(4), CAMK1(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CAMK4(4), CASQ1(2), CASQ2(1), CHRM1(3), CHRM2(7), CHRM3(6), CHRM4(2), CHRM5(3), GJA1(8), GJA4(4), GJA5(2), GJB3(2), GJB6(2), GNA11(4), GNAI2(3), GNAI3(5), GNAO1(1), GNAQ(1), GNAZ(6), GNB1(1), GNB2(3), GNB3(1), GNB4(4), GNG12(1), GNG7(2), GNGT1(3), GRK4(1), GRK5(1), ITPR1(17), ITPR2(18), ITPR3(16), KCNB1(5), KCNJ3(6), KCNJ5(2), MIB1(2), NME7(1), PLCB3(8), PRKACA(1), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCQ(2), PRKD1(6), RGS1(1), RGS10(2), RGS11(2), RGS14(1), RGS16(2), RGS17(1), RGS18(3), RGS19(1), RGS2(2), RGS20(2), RGS3(11), RGS5(1), RGS6(7), RGS7(2), RGS9(4), RYR1(33), RYR2(43), RYR3(40), SLC8A1(6), SLC8A3(5), USP5(4), YWHAH(1), YWHAQ(2)	37386307	633	105	626	239	244	183	30	111	65	0	0.079	1.00	1.00
257	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	243	ACVR1B(7), ACVR1C(3), AKT1(2), AKT2(2), AKT3(3), ARRB1(3), ARRB2(3), ATF4(1), BDNF(1), BRAF(5), CACNA1A(11), CACNA1B(14), CACNA1C(23), CACNA1D(15), CACNA1E(26), CACNA1F(2), CACNA1G(11), CACNA1H(11), CACNA1I(14), CACNA1S(10), CACNA2D1(6), CACNA2D2(5), CACNA2D3(6), CACNA2D4(9), CACNB1(1), CACNB2(10), CACNB4(3), CACNG2(1), CACNG3(3), CACNG4(3), CACNG5(3), CACNG6(1), CACNG7(5), CASP3(1), CD14(1), CDC25B(4), CDC42(1), CRK(1), DAXX(3), DDIT3(3), DUSP1(1), DUSP10(3), DUSP14(1), DUSP16(3), DUSP2(2), DUSP4(1), DUSP5(3), DUSP6(1), DUSP8(1), DUSP9(2), ECSIT(1), EGF(5), EGFR(10), ELK1(2), ELK4(4), FAS(3), FGF1(2), FGF10(4), FGF11(1), FGF12(4), FGF13(4), FGF14(4), FGF17(2), FGF18(2), FGF2(2), FGF20(1), FGF21(1), FGF23(1), FGF5(1), FGF6(5), FGF7(1), FGF9(5), FGFR1(8), FGFR2(5), FGFR3(1), FGFR4(6), FLNA(11), FLNB(6), FLNC(21), GNA12(1), GNG12(1), GRB2(1), IKBKB(3), IL1B(1), IL1R1(3), IL1R2(1), JUN(2), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K5(1), MAP2K6(2), MAP2K7(13), MAP3K1(8), MAP3K10(6), MAP3K12(4), MAP3K13(5), MAP3K14(3), MAP3K2(2), MAP3K3(2), MAP3K4(10), MAP3K5(3), MAP3K6(5), MAP3K7(7), MAP3K8(1), MAP4K1(2), MAP4K2(4), MAP4K3(2), MAP4K4(5), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(8), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3), MAPKAPK3(3), MAPKAPK5(2), MAPT(4), MAX(1), MEF2C(2), MKNK1(1), MOS(3), NF1(14), NFATC2(8), NFATC4(11), NFKB1(5), NFKB2(3), NLK(5), NR4A1(2), NRAS(1), NTF3(2), NTRK1(4), NTRK2(5), PAK1(4), PAK2(5), PDGFA(1), PDGFB(3), PDGFRA(4), PDGFRB(8), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PPM1A(3), PPM1B(8), PPP3CA(3), PPP3CB(1), PPP3R2(1), PPP5C(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), PTPN5(1), PTPN7(2), PTPRR(4), RAC2(1), RAC3(1), RAF1(6), RAP1A(2), RAP1B(4), RAPGEF2(9), RASA2(7), RASGRF1(6), RASGRF2(10), RASGRP1(4), RASGRP2(4), RASGRP3(2), RASGRP4(3), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA4(2), RPS6KA6(7), RRAS(3), RRAS2(1), SOS1(4), SOS2(5), SRF(1), STK3(3), STK4(3), STMN1(2), TAOK1(6), TAOK2(8), TAOK3(5), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6), TNF(2), TNFRSF1A(3), TRAF2(2), TRAF6(4), ZAK(3)	55851987	840	102	832	285	297	263	27	161	90	2	0.0031	1.00	1.00
258	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	123	ABL1(2), ABLIM1(3), ABLIM2(3), ABLIM3(4), ARHGEF12(6), CDC42(1), CDK5(2), CFL1(1), CXCR4(2), DCC(19), DPYSL2(1), DPYSL5(4), EFNA1(2), EFNA5(2), EFNB1(1), EFNB2(4), EFNB3(4), EPHA1(8), EPHA2(5), EPHA3(12), EPHA4(7), EPHA5(14), EPHA6(15), EPHA7(3), EPHA8(9), EPHB1(14), EPHB2(11), EPHB3(6), EPHB4(4), EPHB6(6), FES(4), FYN(5), GNAI1(1), GNAI2(3), GNAI3(5), GSK3B(2), ITGB1(4), L1CAM(3), LIMK1(4), LIMK2(4), LRRC4C(5), MAPK1(2), MAPK3(1), MET(4), NCK1(3), NCK2(2), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NGEF(5), NRAS(1), NRP1(11), NTN1(3), NTN4(1), NTNG1(6), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PLXNA1(13), PLXNA2(13), PLXNA3(11), PLXNB1(8), PLXNB2(10), PLXNB3(6), PLXNC1(9), PPP3CA(3), PPP3CB(1), PPP3R2(1), PTK2(7), RAC2(1), RAC3(1), RGS3(11), ROBO1(13), ROBO2(13), ROBO3(6), ROCK1(7), ROCK2(3), SEMA3A(5), SEMA3B(2), SEMA3D(8), SEMA3E(7), SEMA3F(8), SEMA3G(3), SEMA4A(5), SEMA4B(3), SEMA4C(5), SEMA4D(6), SEMA4F(3), SEMA5A(13), SEMA5B(5), SEMA6A(6), SEMA6B(2), SEMA6C(4), SEMA6D(9), SEMA7A(2), SLIT1(5), SLIT2(17), SLIT3(9), SRGAP1(9), SRGAP2(6), SRGAP3(5), UNC5A(6), UNC5B(5), UNC5C(9), UNC5D(7)	38248013	621	101	614	260	190	173	46	144	68	0	0.83	1.00	1.00
259	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(4), ACTG1(2), CHAD(4), COL11A1(15), COL11A2(8), COL17A1(5), COL1A1(7), COL1A2(17), COL2A1(8), COL3A1(8), COL4A1(13), COL4A2(7), COL4A4(7), COL4A6(7), COL5A1(14), COL5A2(6), COL5A3(5), COL6A1(7), COL6A2(8), COL6A3(21), COL6A6(20), COMP(3), DES(1), DSC1(3), DSC2(4), DSC3(4), DSG1(3), DSG2(2), DSG3(6), DSG4(4), FN1(21), GJA1(8), GJA10(2), GJA3(1), GJA4(4), GJA5(2), GJA8(1), GJA9(2), GJB3(2), GJB6(2), GJC2(3), GJD2(3), GJD4(4), IBSP(2), INA(3), ITGA6(2), ITGB4(12), KRT1(2), KRT10(4), KRT12(4), KRT13(7), KRT14(2), KRT15(1), KRT16(3), KRT17(2), KRT18(3), KRT2(6), KRT20(2), KRT23(1), KRT24(1), KRT25(2), KRT27(6), KRT28(5), KRT3(3), KRT31(3), KRT32(3), KRT33A(5), KRT33B(5), KRT34(1), KRT35(2), KRT36(3), KRT37(4), KRT38(1), KRT39(4), KRT4(1), KRT40(1), KRT5(3), KRT6A(5), KRT6B(1), KRT6C(2), KRT7(3), KRT71(2), KRT72(6), KRT73(6), KRT74(3), KRT75(2), KRT76(2), KRT77(2), KRT78(3), KRT79(2), KRT8(3), KRT81(2), KRT82(3), KRT83(2), KRT84(4), KRT85(2), KRT86(1), LAMA1(22), LAMA2(18), LAMA3(10), LAMA4(11), LAMA5(14), LAMB1(9), LAMB2(12), LAMB3(13), LAMB4(9), LAMC1(7), LAMC2(8), LAMC3(11), LMNA(5), LMNB1(2), LMNB2(3), NES(3), PRPH(1), RELN(21), SPP1(1), THBS1(9), THBS2(7), THBS3(4), THBS4(4), TNC(13), TNN(12), TNR(13), TNXB(26), VIM(2), VTN(4), VWF(13)	49259252	730	100	726	317	262	216	22	165	64	1	0.82	1.00	1.00
260	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(9), CD36(2), CD44(5), CHAD(4), COL11A1(15), COL11A2(8), COL1A1(7), COL1A2(17), COL2A1(8), COL3A1(8), COL4A1(13), COL4A2(7), COL4A4(7), COL4A6(7), COL5A1(14), COL5A2(6), COL5A3(5), COL6A1(7), COL6A2(8), COL6A3(21), COL6A6(20), DAG1(7), FN1(21), FNDC1(9), FNDC3A(7), FNDC4(2), GP5(2), GP6(4), HMMR(4), HSPG2(16), IBSP(2), ITGA1(4), ITGA10(6), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGA7(5), ITGA8(5), ITGA9(9), ITGAV(4), ITGB1(4), ITGB3(5), ITGB4(12), ITGB5(3), ITGB6(1), ITGB7(3), ITGB8(7), LAMA1(22), LAMA2(18), LAMA3(10), LAMA4(11), LAMA5(14), LAMB1(9), LAMB2(12), LAMB3(13), LAMB4(9), LAMC1(7), LAMC2(8), LAMC3(11), RELN(21), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SPP1(1), SV2A(5), SV2B(1), SV2C(4), THBS1(9), THBS2(7), THBS3(4), THBS4(4), TNC(13), TNN(12), TNR(13), TNXB(26), VTN(4), VWF(13)	44369538	665	99	660	293	230	195	20	147	72	1	0.89	1.00	1.00
261	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	127	ALCAM(7), CADM1(9), CADM3(5), CD2(2), CD22(1), CD226(2), CD274(1), CD276(3), CD34(2), CD4(3), CD40(1), CD40LG(4), CD58(1), CD6(5), CD80(1), CD86(2), CD8A(2), CD8B(1), CDH15(2), CDH2(10), CDH3(6), CDH4(12), CDH5(4), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(3), CLDN23(3), CLDN4(4), CLDN6(1), CLDN9(3), CNTN1(10), CNTN2(4), CNTNAP1(11), CNTNAP2(15), CTLA4(3), ESAM(6), GLG1(5), HLA-C(4), HLA-DMA(2), HLA-DMB(3), HLA-DOA(1), HLA-DPA1(2), HLA-DPB1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(3), HLA-DRB1(1), HLA-E(3), HLA-F(5), HLA-G(2), ICAM1(2), ICAM2(2), ICAM3(2), ICOS(1), ITGA4(8), ITGA6(2), ITGA8(5), ITGA9(9), ITGAL(7), ITGAM(5), ITGAV(4), ITGB1(4), ITGB2(6), ITGB7(3), ITGB8(7), JAM3(3), L1CAM(3), MADCAM1(2), MAG(6), MPZ(2), NCAM1(2), NCAM2(10), NEGR1(4), NEO1(8), NFASC(10), NLGN1(7), NLGN2(5), NLGN3(8), NRCAM(5), NRXN1(16), NRXN2(13), NRXN3(12), OCLN(1), PDCD1(2), PDCD1LG2(1), PTPRC(16), PTPRF(10), PTPRM(19), PVR(3), PVRL1(2), PVRL2(3), PVRL3(3), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SELE(3), SELL(4), SELP(2), SELPLG(6), SIGLEC1(10), VCAM1(5), VCAN(25)	28564339	505	96	498	201	162	162	14	124	43	0	0.30	1.00	1.00
262	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTA2(5), ACTN2(15), ACTN3(2), ACTN4(1), DES(1), DMD(23), FAM48A(5), MYBPC1(5), MYBPC2(5), MYBPC3(3), MYH3(19), MYH6(9), MYH7(13), MYH8(13), MYL1(1), MYL2(1), MYL3(1), MYL4(1), MYOM1(1), NEB(31), TCAP(1), TMOD1(3), TNNC2(1), TNNI2(5), TNNI3(1), TNNT1(2), TNNT2(2), TPM1(2), TPM3(2), TPM4(3), TTN(273), VIM(2)	27341629	453	95	450	151	124	140	23	136	27	3	0.12	1.00	1.00
263	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ACTA2(5), ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ARRB1(3), ARRB2(3), ATF4(1), ATF5(3), ATP2A2(4), ATP2A3(4), CALCA(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CNN1(1), CORIN(7), CREB3(3), CRHR1(2), DGKZ(1), ETS2(1), GABPA(1), GABPB2(1), GBA2(2), GJA1(8), GNAQ(1), GNB1(1), GNB2(3), GNB3(1), GNB4(4), GNG12(1), GNG7(2), GNGT1(3), GRK4(1), GRK5(1), GUCA2A(1), GUCY1A3(11), IGFBP1(2), IGFBP2(1), IGFBP3(4), IL1B(1), IL6(1), ITPR1(17), ITPR2(18), ITPR3(16), JUN(2), MIB1(2), MYL2(1), MYL4(1), MYLK2(3), NFKB1(5), NOS1(16), NOS3(3), OXT(2), OXTR(4), PDE4B(5), PLCB3(8), PLCD1(1), PLCG1(10), PLCG2(6), PRKACA(1), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(6), PRKCH(5), PRKCQ(2), PRKD1(6), RAMP2(1), RAMP3(3), RGS1(1), RGS10(2), RGS11(2), RGS14(1), RGS16(2), RGS17(1), RGS18(3), RGS19(1), RGS2(2), RGS20(2), RGS3(11), RGS5(1), RGS6(7), RGS7(2), RGS9(4), RYR1(33), RYR2(43), RYR3(40), SLC8A1(6), SP1(3), TNXB(26), USP5(4), YWHAH(1), YWHAQ(2)	34414719	530	94	526	216	202	141	18	119	50	0	0.50	1.00	1.00
264	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	129	ACTB(4), ACTG1(2), ACTN1(3), ACTN2(15), ACTN3(2), ACTN4(1), AKT1(2), AKT2(2), AKT3(3), AMOTL1(4), ASH1L(19), CASK(3), CDC42(1), CGN(8), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(3), CLDN23(3), CLDN4(4), CLDN6(1), CLDN9(3), CSDA(5), CSNK2A1(4), CSNK2A2(1), CTNNA1(5), CTNNA2(13), CTNNA3(5), CTNNB1(11), CTTN(2), EPB41(7), EPB41L1(4), EPB41L2(8), EPB41L3(14), EXOC3(5), EXOC4(4), GNAI1(1), GNAI2(3), GNAI3(5), HCLS1(1), IGSF5(2), INADL(5), JAM3(3), LLGL1(8), LLGL2(4), MAGI1(16), MAGI2(10), MAGI3(5), MLLT4(16), MPDZ(14), MPP5(1), MYH1(8), MYH10(16), MYH11(12), MYH13(15), MYH14(11), MYH15(7), MYH2(14), MYH3(19), MYH4(12), MYH6(9), MYH7(13), MYH7B(12), MYH8(13), MYH9(13), MYL2(1), MYL7(1), NRAS(1), OCLN(1), PARD3(8), PARD6B(1), PARD6G(2), PPM1J(3), PPP2CA(3), PPP2CB(3), PPP2R1A(5), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(3), PPP2R3A(5), PPP2R3B(5), PPP2R4(2), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCI(6), PRKCQ(2), PTEN(8), RAB13(2), RAB3B(3), RRAS(3), RRAS2(1), SPTAN1(13), SYMPK(5), TJAP1(2), TJP1(6), TJP2(5), TJP3(4), YES1(2), ZAK(3)	38335681	593	93	589	192	202	181	18	132	59	1	0.012	1.00	1.00
265	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	248	ACVR1(4), ACVR1B(7), ACVR2B(3), AMHR2(3), BMP2(2), BMP7(2), BMPR1A(1), BMPR1B(3), BMPR2(10), CCL11(1), CCL15(1), CCL18(2), CCL2(1), CCL20(1), CCL23(1), CCL25(1), CCL27(1), CCL5(1), CCL7(1), CCL8(2), CCR1(2), CCR2(3), CCR3(4), CCR5(1), CCR6(1), CCR8(2), CCR9(1), CD27(2), CD40(1), CD40LG(4), CD70(1), CLCF1(1), CNTF(2), CNTFR(3), CSF1R(7), CSF2RA(6), CSF2RB(7), CSF3(1), CSF3R(6), CX3CL1(5), CX3CR1(4), CXCL16(2), CXCL2(1), CXCL9(1), CXCR4(2), CXCR6(1), EDA(1), EDAR(5), EGF(5), EGFR(10), EPOR(2), FAS(3), FLT1(6), FLT3(7), FLT4(8), GDF5(5), GH1(3), GH2(3), GHR(5), HGF(11), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(5), IFNAR2(4), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), IFNK(1), IFNW1(1), IL10(1), IL10RA(2), IL10RB(1), IL11(2), IL11RA(2), IL12B(2), IL12RB1(4), IL12RB2(5), IL13(2), IL13RA1(2), IL15RA(1), IL17B(1), IL17RA(6), IL17RB(1), IL18R1(2), IL18RAP(2), IL1B(1), IL1R1(3), IL1R2(1), IL1RAP(3), IL2(1), IL20(1), IL20RA(3), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(5), IL25(2), IL26(1), IL28A(2), IL28B(3), IL2RA(1), IL3(1), IL3RA(4), IL4R(1), IL5RA(1), IL6(1), IL6ST(2), IL7R(3), IL8(1), INHBA(6), INHBB(9), INHBC(1), INHBE(1), KDR(7), KIT(6), KITLG(3), LEPR(8), LIF(2), LIFR(7), LTA(2), LTBR(2), MET(4), NGFR(5), OSM(4), OSMR(3), PDGFB(3), PDGFC(3), PDGFRA(4), PDGFRB(8), PF4V1(1), PRL(2), PRLR(2), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6), TNF(2), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(2), TNFRSF10D(2), TNFRSF11A(4), TNFRSF11B(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF19(3), TNFRSF1A(3), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(2), TNFRSF8(2), TNFRSF9(3), TNFSF10(2), TNFSF11(1), TNFSF15(1), TNFSF18(2), TNFSF8(1), TPO(13), TSLP(4), VEGFC(3), XCL1(1), XCR1(3)	34646448	487	91	482	196	148	155	24	112	46	2	0.47	1.00	1.00
266	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	141	APC(20), APC2(6), AXIN1(7), AXIN2(3), BTRC(3), CACYBP(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CCND1(1), CCND2(1), CCND3(2), CER1(3), CHD8(9), CREBBP(13), CSNK1A1L(3), CSNK1E(6), CSNK2A1(4), CSNK2A2(1), CTBP1(2), CTBP2(4), CTNNB1(11), CTNNBIP1(1), CUL1(10), CXXC4(2), DAAM1(8), DAAM2(5), DKK1(5), DKK2(2), DKK4(2), DVL1(4), DVL2(3), DVL3(5), EP300(15), FBXW11(5), FZD1(8), FZD10(8), FZD2(3), FZD3(4), FZD4(2), FZD5(1), FZD6(8), FZD7(2), FZD8(4), GSK3B(2), JUN(2), LEF1(4), LRP5(9), LRP6(3), MAP3K7(7), MAPK10(3), MAPK8(4), MAPK9(3), MMP7(1), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NKD1(6), NKD2(1), NLK(5), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PORCN(3), PPARD(5), PPP2CA(3), PPP2CB(3), PPP2R1A(5), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(3), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRICKLE1(9), PRICKLE2(12), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), PSEN1(1), RAC2(1), RAC3(1), ROCK1(7), ROCK2(3), RUVBL1(4), SENP2(3), SFRP1(3), SFRP2(2), SFRP4(2), SFRP5(1), SIAH1(1), SMAD2(8), SMAD3(2), SOX17(4), TBL1X(2), TBL1XR1(2), TCF7(2), TCF7L1(3), TCF7L2(5), VANGL1(3), WIF1(2), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(5), WNT3A(1), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2)	31405965	506	91	497	174	169	155	16	98	65	3	0.035	1.00	1.00
267	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(3), ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ADK(1), ADSL(4), ADSS(3), ADSSL1(7), AK5(3), AK7(2), ALLC(3), AMPD1(3), AMPD2(5), AMPD3(7), APRT(2), ATIC(5), CANT1(4), DCK(1), DGUOK(1), ENPP1(1), ENPP3(3), ENTPD1(3), ENTPD3(3), ENTPD4(6), ENTPD6(1), ENTPD8(4), FHIT(1), GART(6), GDA(1), GMPR(3), GMPR2(2), GMPS(3), GUCY1A2(6), GUCY1A3(11), GUCY1B3(7), GUCY2C(6), GUCY2D(8), GUCY2F(7), GUK1(2), IMPDH1(1), IMPDH2(1), NME6(3), NME7(1), NPR1(6), NPR2(5), NT5C(1), NT5C1A(1), NT5C1B(4), NT5C2(5), NUDT2(2), NUDT5(1), NUDT9(1), PAPSS1(4), PAPSS2(2), PDE10A(1), PDE11A(2), PDE1A(3), PDE1C(3), PDE2A(6), PDE3B(10), PDE4A(4), PDE4B(5), PDE4C(2), PDE5A(5), PDE6G(1), PDE7A(5), PDE7B(3), PDE8A(6), PDE8B(3), PDE9A(5), PFAS(2), PKLR(4), PKM2(2), PNPT1(3), POLA1(4), POLA2(2), POLD1(7), POLD3(2), POLE(14), POLE2(2), POLE3(1), POLE4(1), POLR1A(8), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(6), POLR3G(1), POLR3K(1), PPAT(1), PRIM1(1), PRIM2(3), PRPS1(1), PRPS1L1(2), PRPS2(3), PRUNE(3), RRM1(4), RRM2(2), RRM2B(2), XDH(9)	32387372	433	89	432	163	144	153	16	91	29	0	0.27	1.00	1.00
268	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	159	ADORA1(4), ADORA2B(1), ADORA3(2), ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRA2A(2), ADRA2C(3), ADRB1(3), ADRB2(4), ADRB3(1), AGTR1(1), AGTR2(1), AVPR1A(7), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(3), C3AR1(2), CCBP2(3), CCKAR(2), CCKBR(4), CCR1(2), CCR10(2), CCR2(3), CCR3(4), CCR5(1), CCR6(1), CCR8(2), CCR9(1), CCRL1(5), CHML(2), CHRM1(3), CHRM2(7), CHRM3(6), CHRM4(2), CHRM5(3), CMKLR1(1), CNR1(5), CX3CR1(4), CXCR4(2), DRD1(3), DRD2(6), DRD3(8), DRD4(1), DRD5(10), EDNRA(3), F2R(2), F2RL1(3), F2RL2(1), FPR1(1), GALR1(3), GALR2(1), GALR3(1), GALT(1), GHSR(4), GPR17(1), GPR173(3), GPR174(1), GPR27(2), GPR3(3), GPR35(3), GPR37(3), GPR37L1(4), GPR4(2), GPR50(5), GPR6(7), GPR83(5), GPR85(1), GPR87(4), GRPR(3), HCRTR1(3), HCRTR2(2), HRH1(3), HRH2(4), HRH3(3), HTR1A(6), HTR1B(5), HTR1D(4), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(5), HTR2C(3), HTR4(4), HTR5A(4), HTR6(1), HTR7(4), LTB4R(2), MAS1(2), MC3R(3), MC4R(4), MC5R(6), MLNR(2), MTNR1A(3), MTNR1B(2), NMBR(1), NMUR1(2), NMUR2(1), NPY1R(2), NPY2R(1), NPY5R(1), NTSR1(4), OPN1SW(1), OPN3(2), OPRD1(3), OPRK1(4), OPRL1(2), OR10A5(1), OR11A1(3), OR12D3(1), OR1F1(1), OR1Q1(4), OR2H1(1), OR5V1(4), OR7A5(1), OR7C1(3), OR8B8(6), OXTR(4), P2RY1(5), P2RY10(3), P2RY12(8), P2RY13(4), P2RY14(2), P2RY2(1), P2RY6(3), PPYR1(7), PTAFR(2), PTGDR(5), PTGER2(2), PTGER4(1), PTGFR(3), RGR(2), RHO(2), RRH(2), SSTR1(10), SSTR2(2), SSTR3(4), SSTR4(8), SUCNR1(2), TBXA2R(7), TRHR(6)	23206598	436	85	430	155	165	126	16	100	29	0	0.013	1.00	1.00
269	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ADRB1(3), CSNK1D(2), DRD1(3), DRD2(6), EGF(5), EGFR(10), GJA1(8), GJD2(3), GNA11(4), GNAI1(1), GNAI2(3), GNAI3(5), GNAQ(1), GNAS(14), GRB2(1), GRM1(17), GRM5(14), GUCY1A2(6), GUCY1A3(11), GUCY1B3(7), GUCY2C(6), GUCY2D(8), GUCY2F(7), HTR2A(2), HTR2B(5), HTR2C(3), ITPR1(17), ITPR2(18), ITPR3(16), MAP2K1(4), MAP2K2(1), MAP2K5(1), MAP3K2(2), MAPK1(2), MAPK3(1), MAPK7(8), NPR1(6), NPR2(5), NRAS(1), PDGFA(1), PDGFB(3), PDGFC(3), PDGFD(3), PDGFRA(4), PDGFRB(8), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKG1(6), PRKG2(6), PRKX(2), RAF1(6), SOS1(4), SOS2(5), TJP1(6), TUBA1B(1), TUBA1C(2), TUBA3C(6), TUBA3D(5), TUBA3E(5), TUBA8(3), TUBAL3(3), TUBB1(4), TUBB2A(2), TUBB2C(2), TUBB3(8), TUBB4(1), TUBB4Q(2), TUBB6(5), TUBB8(2)	26110176	456	84	452	170	161	140	24	101	30	0	0.20	1.00	1.00
270	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	72	ACTB(4), ACTG1(2), ACTN1(3), ACTN2(15), ACTN3(2), ACTN4(1), ACVR1B(7), ACVR1C(3), BAIAP2(3), CDC42(1), CREBBP(13), CSNK2A1(4), CSNK2A2(1), CTNNA1(5), CTNNA2(13), CTNNA3(5), CTNNB1(11), CTNND1(7), EGFR(10), EP300(15), ERBB2(6), FARP2(4), FER(7), FGFR1(8), FYN(5), IGF1R(11), INSR(10), IQGAP1(5), LEF1(4), LMO7(9), MAP3K7(7), MAPK1(2), MAPK3(1), MET(4), MLLT4(16), NLK(5), PARD3(8), PTPN6(3), PTPRB(12), PTPRF(10), PTPRJ(14), PTPRM(19), PVRL1(2), PVRL2(3), PVRL3(3), PVRL4(4), RAC2(1), RAC3(1), SMAD2(8), SMAD3(2), SNAI1(2), SNAI2(4), SORBS1(7), SSX2IP(3), TCF7(2), TCF7L1(3), TCF7L2(5), TGFBR1(2), TGFBR2(6), TJP1(6), VCL(2), WASF1(4), WASF2(2), WASF3(3), WASL(1), YES1(2)	23084371	373	83	367	128	109	125	12	71	56	0	0.095	1.00	1.00
271	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	107	ABL1(2), ANAPC1(14), ANAPC11(1), ANAPC2(3), ANAPC4(2), ANAPC5(2), ANAPC7(1), ATM(17), ATR(5), BUB1(6), BUB1B(3), BUB3(2), CCNA1(5), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(7), CCND1(1), CCND2(1), CCND3(2), CCNE1(3), CCNE2(1), CCNH(2), CDC14A(6), CDC16(1), CDC20(2), CDC23(4), CDC25A(2), CDC25B(4), CDC25C(3), CDC26(1), CDC27(2), CDC6(2), CDC7(3), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(4), CDKN2D(1), CHEK1(2), CHEK2(5), CREBBP(13), CUL1(10), DBF4(5), E2F2(2), E2F3(1), EP300(15), ESPL1(12), FZR1(3), GSK3B(2), HDAC1(2), HDAC2(4), MAD1L1(6), MAD2L2(1), MCM2(9), MCM3(4), MCM4(6), MCM5(8), MCM6(1), MCM7(5), MDM2(3), ORC1L(10), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PKMYT1(3), PLK1(5), PRKDC(22), RB1(8), RBL1(5), RBL2(1), SKP2(4), SMAD2(8), SMAD3(2), SMC1A(4), SMC1B(3), TFDP1(2), TGFB1(3), TGFB2(6), TGFB3(4), WEE1(1), YWHAG(1), YWHAH(1), YWHAQ(2), YWHAZ(1)	26691859	354	82	344	145	100	110	17	72	54	1	0.87	1.00	1.00
272	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	94	ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ATF4(1), CACNA1C(23), CACNA1D(15), CACNA1F(2), CACNA1S(10), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CDC42(1), EGFR(10), ELK1(2), FSHB(2), GNA11(4), GNAQ(1), GNAS(14), GNRH1(1), GNRH2(1), GNRHR(3), GRB2(1), ITPR1(17), ITPR2(18), ITPR3(16), JUN(2), LHB(1), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(13), MAP3K1(8), MAP3K2(2), MAP3K3(2), MAP3K4(10), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(8), MAPK8(4), MAPK9(3), MMP14(1), MMP2(4), NRAS(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLD1(7), PLD2(11), PRKACA(1), PRKACB(2), PRKACG(3), PRKCD(3), PRKX(2), PTK2B(8), RAF1(6), SOS1(4), SOS2(5)	25158635	408	81	406	141	143	134	15	72	44	0	0.043	1.00	1.00
273	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT1(2), AKT2(2), AKT3(3), CBL(2), CBLB(2), CBLC(2), CCND1(1), CCND2(1), CCND3(2), CISH(2), CLCF1(1), CNTF(2), CNTFR(3), CREBBP(13), CSF2RA(6), CSF2RB(7), CSF3(1), CSF3R(6), EP300(15), EPOR(2), GH1(3), GH2(3), GHR(5), GRB2(1), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(5), IFNAR2(4), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), IFNK(1), IFNW1(1), IL10(1), IL10RA(2), IL10RB(1), IL11(2), IL11RA(2), IL12B(2), IL12RB1(4), IL12RB2(5), IL13(2), IL13RA1(2), IL13RA2(7), IL15RA(1), IL2(1), IL20(1), IL20RA(3), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(5), IL26(1), IL28A(2), IL28B(3), IL2RA(1), IL3(1), IL3RA(4), IL4R(1), IL5RA(1), IL6(1), IL6ST(2), IL7R(3), IRF9(4), JAK1(4), JAK2(8), JAK3(3), LEPR(8), LIF(2), LIFR(7), OSM(4), OSMR(3), PIAS1(3), PIAS2(5), PIAS3(1), PIAS4(4), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PIM1(2), PRL(2), PRLR(2), PTPN11(4), PTPN6(3), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(3), SOCS7(2), SOS1(4), SOS2(5), SPRED1(3), SPRED2(6), SPRY1(2), SPRY2(1), SPRY3(4), SPRY4(3), STAM(4), STAM2(3), STAT1(6), STAT2(4), STAT3(7), STAT4(4), STAT5A(1), STAT5B(4), TPO(13), TSLP(4), TYK2(6)	28180306	392	80	389	140	108	137	17	89	40	1	0.19	1.00	1.00
274	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(3), ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADK(1), ADSL(4), ADSS(3), AK5(3), ALLC(3), AMPD1(3), AMPD2(5), AMPD3(7), APRT(2), ATIC(5), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5G3(1), ATP5J(1), ATP5J2(1), CANT1(4), DCK(1), DGUOK(1), ENPP1(1), ENPP3(3), ENTPD1(3), FHIT(1), GART(6), GDA(1), GMPS(3), GUCY1A2(6), GUCY1A3(11), GUCY1B3(7), GUCY2C(6), GUCY2D(8), GUCY2F(7), GUK1(2), IMPDH1(1), IMPDH2(1), NPR1(6), NPR2(5), NT5C(1), NUDT2(2), PAPSS1(4), PAPSS2(2), PDE1A(3), PDE4A(4), PDE4B(5), PDE4C(2), PDE5A(5), PDE6B(7), PDE6C(2), PDE6G(1), PDE7B(3), PDE8A(6), PDE9A(5), PFAS(2), PKLR(4), PKM2(2), POLD1(7), POLE(14), POLG(4), POLL(1), POLQ(14), POLR1B(2), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(9), PPAT(1), PRPS1(1), PRPS1L1(2), PRPS2(3), PRUNE(3), RRM1(4), RRM2(2)	25367375	338	79	337	139	106	124	13	73	22	0	0.62	1.00	1.00
275	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), AKAP1(1), AKAP10(2), AKAP11(5), AKAP12(5), AKAP3(5), AKAP4(8), AKAP6(11), AKAP7(6), AKAP8(7), AKAP9(16), ARHGEF1(2), CALM1(1), CALM2(2), CALM3(1), CHMP1B(2), GNA11(4), GNA12(1), GNA14(2), GNA15(2), GNAI2(3), GNAI3(5), GNAO1(1), GNAQ(1), GNAZ(6), GNB1(1), GNB2(3), GNB3(1), GNG12(1), GNG7(2), GNGT1(3), GNGT2(1), ITPR1(17), KCNJ3(6), NRAS(1), PDE1A(3), PDE1B(2), PDE1C(3), PDE4A(4), PDE4B(5), PDE4C(2), PDE7A(5), PDE7B(3), PDE8A(6), PDE8B(3), PLCB3(8), PPP3CA(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCI(6), PRKCQ(2), PRKD1(6), PRKD3(1), RRAS(3), SLC9A1(6), USP5(4)	23028653	313	78	306	123	111	98	10	57	37	0	0.36	1.00	1.00
276	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CALM1(1), CALM2(2), CALM3(1), CDS1(4), CDS2(1), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKI(5), DGKQ(2), DGKZ(1), FN3K(2), IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(3), INPP5B(2), INPP5D(1), INPP5E(2), INPPL1(13), ITGB1BP3(3), ITPK1(2), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), OCRL(4), PI4KA(10), PI4KB(4), PIK3C2A(4), PIK3C2B(12), PIK3C2G(3), PIK3C3(8), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1C(6), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLCD1(1), PLCD3(6), PLCE1(9), PLCG1(10), PLCG2(6), PLCZ1(2), PRKCG(4), PTEN(8), PTPMT1(1), SYNJ1(7), SYNJ2(15)	24313905	340	78	332	116	111	107	10	70	41	1	0.10	1.00	1.00
277	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(6), BRAF(5), CACNA1A(11), CRHR1(2), GNA11(4), GNA12(1), GNAI1(1), GNAI2(3), GNAI3(5), GNAO1(1), GNAQ(1), GNAS(14), GNAZ(6), GRIA1(11), GRIA2(13), GRIA3(6), GRID2(11), GRM1(17), GRM5(14), GUCY1A2(6), GUCY1A3(11), GUCY1B3(7), GUCY2C(6), GUCY2D(8), GUCY2F(7), IGF1(2), IGF1R(11), ITPR1(17), ITPR2(18), ITPR3(16), LYN(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), NOS1(16), NOS3(3), NPR1(6), NPR2(5), NRAS(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PPP2CA(3), PPP2CB(3), PPP2R1A(5), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(3), PRKCG(4), PRKG1(6), PRKG2(6), RAF1(6), RYR1(33)	21737075	416	78	412	128	148	119	21	97	31	0	0.013	1.00	1.00
278	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ABL1(2), ATM(17), BUB1(6), BUB1B(3), BUB3(2), CCNA1(5), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(7), CCND2(1), CCND3(2), CCNE1(3), CCNE2(1), CCNH(2), CDAN1(5), CDC14A(6), CDC20(2), CDC25A(2), CDC25B(4), CDC25C(3), CDC6(2), CDC7(3), CDK2(2), CDKN1A(1), CDKN2A(4), CHEK1(2), CHEK2(5), DTX4(4), E2F2(2), E2F3(1), E2F5(1), EP300(15), ESPL1(12), GSK3B(2), HDAC1(2), HDAC2(4), HDAC3(4), HDAC4(7), HDAC5(4), HDAC6(3), HDAC8(3), MAD1L1(6), MAD2L2(1), MCM2(9), MCM3(4), MCM4(6), MCM5(8), MCM6(1), MCM7(5), MDM2(3), MPEG1(5), ORC1L(10), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PLK1(5), PRKDC(22), PTPRA(5), RB1(8), RBL1(5), SKP2(4), TBC1D8(6), TFDP1(2), TGFB1(3), WEE1(1)	21185680	292	77	289	111	88	80	16	63	44	1	0.63	1.00	1.00
279	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	97	ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ASIP(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CREB1(4), CREB3(3), CREB3L1(3), CREB3L2(1), CREB3L3(3), CREB3L4(1), CREBBP(13), CTNNB1(11), DCT(7), DVL1(4), DVL2(3), DVL3(5), EDN1(3), EP300(15), FZD1(8), FZD10(8), FZD2(3), FZD3(4), FZD4(2), FZD5(1), FZD6(8), FZD7(2), FZD8(4), GNAI1(1), GNAI2(3), GNAI3(5), GNAO1(1), GNAQ(1), GNAS(14), GSK3B(2), KIT(6), KITLG(3), LEF1(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MITF(6), NRAS(1), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), POMC(5), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), RAF1(6), TCF7(2), TCF7L1(3), TCF7L2(5), TYR(5), TYRP1(5), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(5), WNT3A(1), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2)	21151352	369	77	363	150	134	110	12	71	41	1	0.39	1.00	1.00
280	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(3), BCAR1(4), CAPN1(3), CAPN10(1), CAPN11(3), CAPN2(4), CAPN3(5), CAPN5(2), CAPN6(8), CAPN7(5), CAPN9(3), CAPNS1(1), CAV1(2), CDC42(1), CRK(1), CSK(3), DOCK1(12), FYN(5), GIT2(1), GRB2(1), ILK(2), ITGA10(6), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGA7(5), ITGA8(5), ITGA9(9), ITGAD(6), ITGAE(4), ITGAL(7), ITGAM(5), ITGAV(4), ITGAX(6), ITGB1(4), ITGB2(6), ITGB3(5), ITGB4(12), ITGB5(3), ITGB6(1), ITGB7(3), ITGB8(7), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K6(2), MAPK10(3), MAPK4(4), MAPK6(1), MAPK7(8), MYLK2(3), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PDPK1(1), PIK3R2(4), PTK2(7), PXN(2), RAC2(1), RAC3(1), RAP1B(4), RAPGEF1(6), RHO(2), ROCK1(7), ROCK2(3), SHC1(3), SHC3(4), SORBS1(7), SOS1(4), TLN1(13), TNS1(15), VASP(3), VAV2(8), VAV3(6), VCL(2), ZYX(2)	26589722	357	77	355	149	122	105	15	70	44	1	0.75	1.00	1.00
281	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(3), ACTN2(15), ACTN3(2), ACTN4(1), ARHGAP5(6), BCAR1(4), CDC42(1), CDH5(4), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(3), CLDN23(3), CLDN4(4), CLDN6(1), CLDN9(3), CTNNA1(5), CTNNA2(13), CTNNA3(5), CTNNB1(11), CTNND1(7), CXCR4(2), CYBA(1), CYBB(4), ESAM(6), GNAI1(1), GNAI2(3), GNAI3(5), GRLF1(8), ICAM1(2), ITGA4(8), ITGAL(7), ITGAM(5), ITGB1(4), ITGB2(6), ITK(4), JAM3(3), MAPK11(1), MAPK13(1), MAPK14(1), MLLT4(16), MMP2(4), MMP9(6), MSN(3), MYL2(1), MYL7(1), NCF1(2), NCF2(1), NCF4(1), NOX1(4), NOX3(3), OCLN(1), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLCG1(10), PLCG2(6), PRKCG(4), PTK2(7), PTK2B(8), PTPN11(4), PXN(2), RAC2(1), RAP1A(2), RAP1B(4), RAPGEF3(2), RAPGEF4(3), RASSF5(1), RHOH(1), ROCK1(7), ROCK2(3), TXK(1), VASP(3), VAV1(7), VAV2(8), VAV3(6), VCAM1(5), VCL(2)	24067467	362	76	355	154	126	113	12	67	43	1	0.74	1.00	1.00
282	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(3), ALG1(3), ALG10(5), ALG10B(2), ALG12(1), ALG13(2), ALG2(1), ALG3(2), ALG8(1), ALG9(2), B3GNT1(1), B3GNT2(1), B3GNT7(4), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), B4GALT5(3), B4GALT7(1), C1GALT1(1), C1GALT1C1(4), CHPF(2), CHST1(11), CHST11(1), CHST12(6), CHST13(1), CHST2(8), CHST3(1), CHST6(5), CHST7(1), CHSY1(3), EXT1(9), EXT2(6), EXTL1(4), EXTL2(2), EXTL3(8), FUT11(2), FUT8(3), GALNT1(3), GALNT10(3), GALNT11(5), GALNT12(2), GALNT13(3), GALNT14(6), GALNT2(3), GALNT3(1), GALNT4(1), GALNT5(4), GALNT6(2), GALNT8(5), GALNT9(3), GALNTL1(2), GALNTL2(6), GALNTL4(5), GALNTL5(4), GANAB(3), GCNT1(1), GCNT3(2), GCNT4(2), HS2ST1(1), HS3ST1(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), HS3ST5(4), HS6ST1(2), HS6ST2(1), HS6ST3(4), MAN1A2(1), MAN1B1(2), MAN1C1(3), MAN2A1(7), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(1), MGAT5(6), MGAT5B(3), NDST1(8), NDST2(5), NDST3(5), NDST4(10), OGT(2), RPN1(1), RPN2(3), ST3GAL1(3), ST3GAL2(4), ST3GAL3(2), ST3GAL4(3), ST6GALNAC1(2), STT3B(5), UST(5), XYLT1(7), XYLT2(4)	21513621	313	75	310	135	115	97	10	66	25	0	0.86	1.00	1.00
283	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(13), BDKRB1(1), BDKRB2(3), C1QA(1), C1QC(3), C1R(5), C1S(4), C2(2), C3(16), C3AR1(2), C5(9), C5AR1(1), C6(8), C7(2), C8A(6), C8B(8), C9(3), CD46(1), CD55(1), CD59(1), CFB(3), CFH(12), CFI(3), CPB2(4), CR1(17), CR2(4), F10(3), F11(3), F12(2), F13A1(9), F13B(8), F2(4), F2R(2), F3(1), F5(9), F7(6), F8(13), F9(4), FGA(5), FGB(3), FGG(2), KLKB1(4), KNG1(4), MASP1(4), MASP2(2), MBL2(1), PLAT(2), PLAU(2), PLG(10), PROC(3), PROS1(6), SERPINA1(4), SERPINA5(1), SERPINC1(2), SERPIND1(3), SERPINE1(2), SERPINF2(6), SERPING1(6), TFPI(3), THBD(1), VWF(13)	17979520	286	75	283	76	78	85	8	79	33	3	0.0035	1.00	1.00
284	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(11), ADCY8(12), ARAF(6), ATF4(1), BRAF(5), CACNA1C(23), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CAMK4(4), CREBBP(13), EP300(15), GNAQ(1), GRIA1(11), GRIA2(13), GRIN1(4), GRIN2A(7), GRIN2B(13), GRIN2C(4), GRIN2D(1), GRM1(17), GRM5(14), ITPR1(17), ITPR2(18), ITPR3(16), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), NRAS(1), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R12A(1), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), RAF1(6), RAP1A(2), RAP1B(4), RAPGEF3(2), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA6(7)	19684978	336	75	335	116	108	116	13	57	42	0	0.076	1.00	1.00
285	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(15), ACACB(13), AKT1(2), AKT2(2), AKT3(3), ARAF(6), BAD(1), BRAF(5), CALM1(1), CALM2(2), CALM3(1), CBL(2), CBLB(2), CBLC(2), CRK(1), EIF4EBP1(1), ELK1(2), EXOC7(6), FASN(11), FBP1(1), FBP2(3), FLOT1(1), FLOT2(3), FOXO1(1), GCK(3), GRB2(1), GSK3B(2), GYS1(4), GYS2(2), IKBKB(3), INPP5D(1), INSR(10), IRS1(7), IRS2(3), IRS4(11), LIPE(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK9(3), MKNK1(1), NRAS(1), PCK1(4), PCK2(6), PDE3A(8), PDE3B(10), PDPK1(1), PFKL(7), PFKM(3), PFKP(8), PHKA1(5), PHKA2(7), PHKB(3), PHKG1(2), PHKG2(3), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PKLR(4), PKM2(2), PPARGC1A(6), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R3A(12), PPP1R3B(5), PPP1R3C(3), PPP1R3D(3), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAB2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAG3(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKCI(6), PRKX(2), PTPRF(10), PYGB(4), PYGL(5), PYGM(7), RAF1(6), RAPGEF1(6), RHEB(1), RPS6(1), RPS6KB1(3), RPS6KB2(3), SH2B2(3), SHC1(3), SHC2(2), SHC3(4), SHC4(1), SLC2A4(1), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(3), SORBS1(7), SOS1(4), SOS2(5), SREBF1(4), TRIP10(7), TSC1(4), TSC2(4)	31055141	448	75	446	181	150	149	15	85	48	1	0.50	1.00	1.00
286	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(4), ACVR1B(7), ACVRL1(2), AKT1(2), AURKB(2), BMPR1A(1), BMPR2(10), BUB1(6), CDKL1(3), CDKL2(3), CDS1(4), CDS2(1), CLK1(3), CLK2(6), CLK4(3), COL4A3BP(1), CSNK2A1(4), CSNK2A2(1), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKQ(2), DGKZ(1), IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(3), INPPL1(13), ITPKA(1), ITPKB(6), MAP3K10(6), MOS(3), NEK1(4), NEK3(1), OCRL(4), PAK4(5), PIK3C2A(4), PIK3C2B(12), PIK3C2G(3), PIK3CB(6), PIK3CG(10), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLCD1(1), PLCG1(10), PLCG2(6), PLK3(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCQ(2), PRKD1(6), PRKG1(6), RAF1(6), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA4(2), RPS6KB1(3), TGFBR1(2), VRK1(2)	21972463	309	74	303	108	94	93	10	72	37	3	0.35	1.00	1.00
287	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(19), ASH2L(3), C17orf79(2), CARM1(2), CTCFL(5), DOT1L(9), EED(2), EHMT1(7), EHMT2(4), EZH1(2), EZH2(4), FBXO11(6), HCFC1(11), HSF4(2), JMJD4(1), JMJD6(1), KDM6A(6), MEN1(3), MLL(16), MLL2(32), MLL3(36), MLL4(24), MLL5(11), NSD1(13), OGT(2), PAXIP1(6), PPP1CA(2), PPP1CB(1), PPP1CC(2), PRDM2(15), PRDM9(9), PRMT1(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), RBBP5(1), SATB1(8), SETD1A(7), SETD2(4), SETDB1(12), SETDB2(3), SMYD3(2), STK38(1), SUV39H1(4), SUV39H2(1), SUV420H1(4), SUV420H2(1), SUZ12(4), WHSC1(7), WHSC1L1(7)	23513953	335	73	330	116	103	94	7	69	55	7	0.45	1.00	1.00
288	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	77	ABL1(2), ACTN1(3), ACTR2(2), AKT1(2), AKT2(2), AKT3(3), ANGPTL2(4), ARHGEF6(10), ARHGEF7(9), BCAR1(4), BRAF(5), CAV1(2), CDC42(1), CDKN2A(4), CRK(1), CSE1L(3), DOCK1(12), EPHB2(11), FYN(5), GRB2(1), GRB7(6), GRLF1(8), ILK(2), ITGA1(4), ITGA10(6), ITGA11(6), ITGA2(4), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGA7(5), ITGA8(5), ITGA9(9), ITGB3BP(1), MAP2K4(5), MAP2K7(13), MAP3K11(3), MAPK1(2), MAPK10(3), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3), MYLK(9), MYLK2(3), P4HB(4), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PIK3CB(6), PKLR(4), PLCG1(10), PLCG2(6), PTEN(8), PTK2(7), RAF1(6), RHO(2), ROCK1(7), ROCK2(3), SHC1(3), SOS1(4), SOS2(5), TERF2IP(3), TLN1(13), TLN2(22), VASP(3), ZYX(2)	23821781	358	72	354	124	120	103	12	73	50	0	0.18	1.00	1.00
289	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(4), BAD(1), BCL2(1), CABIN1(8), CALM1(1), CALM2(2), CALM3(1), CAMK2B(2), CAMK4(4), CD3E(3), CD3G(2), CDKN1A(1), CNR1(5), CREBBP(13), CSNK2A1(4), CTLA4(3), EGR2(3), EGR3(1), EP300(15), FCER1A(1), FCGR3A(1), GATA3(3), GATA4(3), GRLF1(8), GSK3A(1), GSK3B(2), ICOS(1), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL13(2), IL1B(1), IL2(1), IL2RA(1), IL3(1), IL6(1), IL8(1), ITK(4), KPNA5(5), MAP2K7(13), MAPK14(1), MAPK8(4), MAPK9(3), MEF2A(1), MEF2B(3), MEF2D(6), MYF5(2), NCK2(2), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NFKB2(3), NFKBIB(4), NPPB(1), NUP214(12), OPRD1(3), PAK1(4), PIN1(1), PPP3CB(1), PTPRC(16), RELA(2), RPL13A(1), SLA(1), SP1(3), SP3(3), TGFB1(3), TNF(2), TRAF2(2), TRPV6(4), VAV1(7), VAV2(8), VAV3(6), XPO5(1)	17985403	276	71	274	104	77	94	8	61	36	0	0.41	1.00	1.00
290	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(3), CD14(1), CD19(1), CD1A(1), CD1B(3), CD1C(2), CD1D(5), CD1E(5), CD2(2), CD22(1), CD33(2), CD34(2), CD36(2), CD37(1), CD38(2), CD3E(3), CD3G(2), CD4(3), CD44(5), CD5(5), CD55(1), CD59(1), CD7(4), CD8A(2), CD8B(1), CR1(17), CR2(4), CSF1R(7), CSF2RA(6), CSF3(1), CSF3R(6), EPOR(2), FCER2(2), FLT3(7), GP5(2), GYPA(1), HLA-DRA(3), HLA-DRB1(1), IL11(2), IL11RA(2), IL1B(1), IL1R1(3), IL1R2(1), IL2RA(1), IL3(1), IL3RA(4), IL4R(1), IL5RA(1), IL6(1), IL7R(3), ITGA1(4), ITGA2(4), ITGA2B(5), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGAM(5), ITGB3(5), KIT(6), KITLG(3), MME(5), TFRC(1), THPO(2), TNF(2), TPO(13)	16158087	217	71	214	89	62	65	9	53	26	2	0.67	1.00	1.00
291	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(2), AKT2(2), AKT3(3), BAD(1), CDC42(1), CDK2(2), CDKN2A(4), CREB1(4), CREB3(3), CREB5(2), EBP(1), ERBB4(18), F2RL2(1), GAB1(1), GRB2(1), GSK3A(1), GSK3B(2), IGF1(2), IGFBP1(2), INPPL1(13), IRS1(7), IRS2(3), IRS4(11), MET(4), NOLC1(7), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PARD3(8), PDK1(1), PIK3CD(8), PPP1R13B(6), PREX1(9), PTEN(8), PTK2(7), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KB1(3), SHC1(3), SLC2A4(1), SOS1(4), SOS2(5), TSC1(4), TSC2(4), YWHAG(1), YWHAH(1), YWHAQ(2), YWHAZ(1)	14824396	208	71	205	77	70	65	10	33	30	0	0.30	1.00	1.00
292	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT1(2), AKT2(2), AKT3(3), BCL10(1), CARD11(12), CBL(2), CBLB(2), CBLC(2), CD247(2), CD3E(3), CD3G(2), CD4(3), CD40LG(4), CD8A(2), CD8B(1), CDC42(1), CTLA4(3), FYN(5), GRAP2(1), GRB2(1), ICOS(1), IFNG(2), IKBKB(3), IL10(1), IL2(1), ITK(4), JUN(2), LCK(1), LCP2(7), MALT1(5), MAP3K14(3), MAP3K8(1), NCK1(3), NCK2(2), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NFKB1(5), NFKB2(3), NFKBIB(4), NRAS(1), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PDCD1(2), PDK1(1), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLCG1(10), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKCQ(2), PTPN6(3), PTPRC(16), RASGRP1(4), SOS1(4), SOS2(5), TEC(3), TNF(2), VAV1(7), VAV2(8), VAV3(6), ZAP70(4)	19469275	283	70	278	113	77	94	7	71	34	0	0.67	1.00	1.00
293	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(8), AMY2A(2), AMY2B(4), ASCC3(20), ATP13A2(7), DDX18(8), DDX19A(3), DDX23(6), DDX4(2), DDX41(7), DDX47(2), DDX50(3), DDX51(4), DDX54(6), DDX55(3), DDX56(4), DHX58(4), ENPP1(1), ENPP3(3), ENTPD7(8), EP400(19), ERCC2(4), ERCC3(3), GAA(2), GANC(4), GBA(4), GBA3(1), GBE1(4), GCK(3), GPI(4), GUSB(3), GYS1(4), GYS2(2), HK1(6), HK2(6), HK3(3), IFIH1(4), LYZL1(2), MGAM(7), MOV10L1(4), NUDT5(1), NUDT8(1), PGM1(3), PGM3(6), PYGB(4), PYGL(5), PYGM(7), RAD54B(3), RAD54L(4), RUVBL2(3), SETX(11), SI(11), SKIV2L2(3), SMARCA2(17), SMARCA5(1), TREH(4), UGDH(4), UGP2(1), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), UXS1(3)	24366227	310	69	308	114	101	106	12	52	39	0	0.36	1.00	1.00
294	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(6), ABCA10(9), ABCA12(21), ABCA13(27), ABCA2(6), ABCA3(12), ABCA4(10), ABCA5(7), ABCA6(4), ABCA7(6), ABCA8(7), ABCA9(9), ABCB1(10), ABCB10(7), ABCB11(6), ABCB4(13), ABCB5(6), ABCB6(4), ABCB7(1), ABCB8(4), ABCB9(2), ABCC1(4), ABCC10(4), ABCC11(10), ABCC12(8), ABCC2(12), ABCC3(6), ABCC4(6), ABCC5(11), ABCC6(6), ABCC8(8), ABCC9(20), ABCD1(3), ABCD2(4), ABCD3(3), ABCD4(5), ABCG1(3), ABCG2(3), ABCG4(3), ABCG5(1), ABCG8(4), CFTR(3), TAP1(3), TAP2(7)	23485351	314	69	309	116	95	106	12	64	37	0	0.19	1.00	1.00
295	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	83	ABL1(2), ABL2(3), AKT1(2), AKT2(2), AKT3(3), ARAF(6), BAD(1), BRAF(5), BTC(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CBL(2), CBLB(2), CBLC(2), CDKN1A(1), CRK(1), EGF(5), EGFR(10), EIF4EBP1(1), ELK1(2), ERBB2(6), ERBB3(21), ERBB4(18), EREG(2), GAB1(1), GRB2(1), GSK3B(2), JUN(2), MAP2K1(4), MAP2K2(1), MAP2K4(5), MAP2K7(13), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK9(3), NCK1(3), NCK2(2), NRAS(1), NRG1(9), NRG2(5), NRG3(9), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLCG1(10), PLCG2(6), PRKCG(4), PTK2(7), RAF1(6), RPS6KB1(3), RPS6KB2(3), SHC1(3), SHC2(2), SHC3(4), SHC4(1), SOS1(4), SOS2(5), STAT5A(1), STAT5B(4), TGFA(2)	19787454	303	69	295	112	89	99	12	63	40	0	0.33	1.00	1.00
296	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1(4), ACVR1B(7), ACVR1C(3), ACVR2B(3), ACVRL1(2), AMHR2(3), BMP2(2), BMP4(6), BMP5(6), BMP6(5), BMP7(2), BMP8A(1), BMP8B(2), BMPR1A(1), BMPR1B(3), BMPR2(10), CHRD(1), COMP(3), CREBBP(13), CUL1(10), DCN(2), E2F5(1), EP300(15), FST(1), GDF5(5), GDF6(6), GDF7(1), IFNG(2), INHBA(6), INHBB(9), INHBC(1), INHBE(1), LEFTY2(2), LTBP1(12), MAPK1(2), MAPK3(1), PITX2(2), PPP2CA(3), PPP2CB(3), PPP2R1A(5), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(3), RBL1(5), RBL2(1), ROCK1(7), ROCK2(3), RPS6KB1(3), RPS6KB2(3), SMAD1(1), SMAD2(8), SMAD3(2), SMAD5(1), SMAD6(3), SMAD7(2), SMAD9(6), SMURF1(1), SMURF2(1), SP1(3), TFDP1(2), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6), THBS1(9), THBS2(7), THBS3(4), THBS4(4), TNF(2), ZFYVE16(6), ZFYVE9(2)	19003326	287	69	281	115	106	82	15	45	37	2	0.49	1.00	1.00
297	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	121	ARAF(6), BID(1), BRAF(5), CASP3(1), CD244(1), CD247(2), FAS(3), FCGR3A(1), FCGR3B(2), FYN(5), GRB2(1), HLA-C(4), HLA-E(3), HLA-G(2), ICAM1(2), ICAM2(2), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(5), IFNAR2(4), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), ITGAL(7), ITGB2(6), KIR2DL1(4), KIR2DL3(1), KIR2DL4(3), KIR3DL1(2), KLRC1(2), KLRC2(2), KLRD1(2), LCK(1), LCP2(7), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MICB(1), NCR1(1), NCR2(3), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NRAS(1), PAK1(4), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLCG1(10), PLCG2(6), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRF1(1), PRKCG(4), PTK2B(8), PTPN11(4), PTPN6(3), RAC2(1), RAC3(1), RAF1(6), SH2D1A(1), SH2D1B(1), SH3BP2(3), SHC1(3), SHC2(2), SHC3(4), SHC4(1), SOS1(4), SOS2(5), SYK(3), TNF(2), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(2), TNFRSF10D(2), TNFSF10(2), ULBP1(2), ULBP3(1), VAV1(7), VAV2(8), VAV3(6), ZAP70(4)	21497685	319	68	315	113	87	112	10	66	44	0	0.17	1.00	1.00
298	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(17), CCNA1(5), CCNB1(1), CCND1(1), CCND2(1), CCND3(2), CCNE1(3), CCNE2(1), CCNG2(1), CCNH(2), CDC25A(2), CDK2(2), CDKN1A(1), CDKN2A(4), CDKN2D(1), CREB3(3), CREB3L1(3), CREB3L3(3), CREB3L4(1), E2F2(2), E2F3(1), E2F5(1), GBA2(2), MCM2(9), MCM3(4), MCM4(6), MCM5(8), MCM6(1), MCM7(5), MDM2(3), MNAT1(2), MYT1(12), NACA(1), ORC1L(10), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(2), POLE(14), POLE2(2), PRIM1(1), RB1(8), RBL1(5), RPA1(1), RPA2(1), RPA3(1), TFDP1(2), TFDP2(3), TNXB(26), WEE1(1)	15062550	202	65	200	85	77	55	7	42	20	1	0.69	1.00	1.00
299	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(2), BDKRB2(3), CALM1(1), CALM2(2), CALM3(1), CAV1(2), CHRM1(3), CHRNA1(3), FLT1(6), FLT4(8), KDR(7), NOS3(3), PDE2A(6), PDE3A(8), PDE3B(10), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKG1(6), PRKG2(6), RYR2(43), SLC7A1(2)	8100208	138	65	138	54	37	51	5	39	6	0	0.37	1.00	1.00
300	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(2), AK3(4), CAD(7), CANT1(4), CDA(2), CTPS(2), CTPS2(2), DCK(1), DCTD(1), DHODH(1), DPYD(13), DPYS(2), DTYMK(1), DUT(1), ENTPD1(3), ENTPD3(3), ENTPD4(6), ENTPD6(1), ENTPD8(4), NME6(3), NME7(1), NT5C(1), NT5C1A(1), NT5C1B(4), NT5C2(5), NUDT2(2), PNPT1(3), POLA1(4), POLA2(2), POLD1(7), POLD3(2), POLE(14), POLE2(2), POLE3(1), POLE4(1), POLR1A(8), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(6), POLR3G(1), POLR3K(1), PRIM1(1), PRIM2(3), RRM1(4), RRM2(2), RRM2B(2), TK1(2), TK2(3), TXNRD1(5), TXNRD2(3), TYMS(1), UCK1(2), UCK2(1), UMPS(1), UPB1(2), UPP1(1), UPP2(5), UPRT(1)	16087881	201	64	201	70	64	64	10	39	24	0	0.19	1.00	1.00
301	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(20), AXIN1(7), CCND1(1), CCND2(1), CCND3(2), CSNK1E(6), CTNNB1(11), DVL1(4), DVL2(3), DVL3(5), FBXW2(2), FZD1(8), FZD10(8), FZD2(3), FZD3(4), FZD5(1), FZD6(8), FZD7(2), FZD8(4), GSK3B(2), JUN(2), LDLR(4), MAPK10(3), MAPK9(3), PAFAH1B1(3), PLAU(2), PPP2R5C(1), PPP2R5E(4), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCI(6), PRKCQ(2), PRKD1(6), SFRP4(2), TCF7(2), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(5), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2)	11722217	195	64	191	83	68	39	8	47	30	3	0.69	1.00	1.00
302	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	51	ADORA3(2), CCKBR(4), CCR2(3), CCR3(4), CCR5(1), CELSR1(14), CELSR2(18), CELSR3(15), CHRM2(7), CHRM3(6), CIDEB(1), DRD4(1), EDNRA(3), EMR2(3), EMR3(4), F2R(2), GNRHR(3), GPR116(14), GPR132(1), GPR133(8), GPR135(6), GPR143(1), GPR17(1), GPR55(5), GPR56(1), GPR61(3), GPR84(1), GRM1(17), GRPR(3), HRH4(1), LGR6(4), LPHN2(11), LPHN3(11), LTB4R2(3), NTSR1(4), OR2M4(1), OR8G2(5), P2RY13(4), PTGFR(3), SMO(6), SSTR2(2), TAAR5(3), TSHR(8), VN1R1(3)	12785250	221	62	219	65	67	67	8	64	15	0	0.014	1.00	1.00
303	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(6), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH3A1(5), ALDH3B2(4), AOC2(4), AOC3(3), AOX1(3), CARM1(2), COMT(3), DBH(2), DCT(7), DDC(3), ESCO2(2), FAH(2), GOT1(2), GOT2(3), GSTZ1(3), HGD(2), HPD(1), LCMT1(1), LCMT2(7), MAOA(1), MAOB(3), METTL6(1), MYST3(11), MYST4(15), NAT6(2), PNMT(3), PNPLA3(2), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), SH3GLB1(1), TAT(1), TH(1), TPO(13), TYR(5), TYRP1(5), WBSCR22(2)	11774058	174	62	173	50	49	49	5	48	21	2	0.047	1.00	1.00
304	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	BRAF(5), CREB1(4), DAXX(3), ELK1(2), GRB2(1), IKBKB(3), JUN(2), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K5(1), MAP2K6(2), MAP2K7(13), MAP3K1(8), MAP3K10(6), MAP3K11(3), MAP3K12(4), MAP3K13(5), MAP3K14(3), MAP3K2(2), MAP3K3(2), MAP3K4(10), MAP3K5(3), MAP3K6(5), MAP3K7(7), MAP3K8(1), MAP3K9(5), MAP4K1(2), MAP4K2(4), MAP4K3(2), MAP4K4(5), MAP4K5(4), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(4), MAPK6(1), MAPK7(8), MAPK8(4), MAPK9(3), MAPKAPK3(3), MAPKAPK5(2), MAX(1), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), MKNK1(1), NFKB1(5), PAK1(4), PAK2(5), RAF1(6), RELA(2), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA4(2), RPS6KB1(3), RPS6KB2(3), SHC1(3), SP1(3), STAT1(6), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TRAF2(2)	18866138	249	62	247	86	88	73	8	44	36	0	0.21	1.00	1.00
305	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	FN3K(2), IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(3), INPP5B(2), INPP5E(2), INPPL1(13), IPMK(1), ISYNA1(2), ITGB1BP3(3), ITPK1(2), ITPKA(1), ITPKB(6), MINPP1(3), MIOX(1), OCRL(4), PI4KA(10), PI4KB(4), PIK3C3(8), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1C(6), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLCD1(1), PLCD3(6), PLCE1(9), PLCG1(10), PLCG2(6), PLCZ1(2), PTEN(8), PTPMT1(1), SYNJ1(7), SYNJ2(15)	14234800	215	61	209	65	72	72	2	43	25	1	0.038	1.00	1.00
306	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	BRAF(5), CPEB1(2), EGFR(10), ERBB2(6), ERBB4(18), ETS1(4), ETS2(1), ETV6(3), ETV7(1), FMN2(15), GRB2(1), MAP2K1(4), MAPK1(2), MAPK3(1), NOTCH1(15), NOTCH2(16), NOTCH3(10), NOTCH4(7), PIWIL1(6), PIWIL2(7), PIWIL3(2), PIWIL4(2), RAF1(6), SOS1(4), SOS2(5), SPIRE1(2), SPIRE2(2)	10157116	157	61	151	68	50	43	7	38	19	0	0.84	1.00	1.00
307	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	96	AKT1(2), AKT2(2), AKT3(3), CASP8(6), CCL5(1), CD14(1), CD40(1), CD80(1), CD86(2), CXCL9(1), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(5), IFNAR2(4), IFNB1(2), IKBKB(3), IKBKE(5), IL12B(2), IL1B(1), IL6(1), IL8(1), IRAK1(5), IRAK4(3), IRF3(3), IRF5(2), IRF7(1), JUN(2), LY96(1), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(13), MAP3K7(7), MAP3K8(1), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), MAPK9(3), MYD88(2), NFKB1(5), NFKB2(3), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), RELA(2), SPP1(1), STAT1(6), TBK1(2), TICAM1(6), TIRAP(2), TLR1(5), TLR2(3), TLR3(2), TLR5(4), TLR6(3), TLR7(3), TLR8(6), TLR9(10), TNF(2), TOLLIP(1), TRAF3(2), TRAF6(4)	16954398	240	61	235	85	70	76	12	50	32	0	0.23	1.00	1.00
308	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(5), AR(8), ESR1(5), ESR2(6), HNF4A(5), NR0B1(2), NR1D1(3), NR1D2(4), NR1H2(4), NR1H3(2), NR1I2(3), NR1I3(3), NR2C2(3), NR2E1(1), NR2F1(4), NR2F2(3), NR2F6(2), NR3C1(5), NR4A1(2), NR4A2(6), NR5A1(5), NR5A2(1), PGR(7), PPARA(3), PPARD(5), PPARG(1), RARA(2), RARB(5), ROR1(6), RORA(2), RORC(3), RXRA(3), RXRG(3), THRA(4), THRB(5), VDR(5)	8268927	136	61	135	51	45	31	7	41	12	0	0.46	1.00	1.00
309	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	ACTR2(2), AKT1(2), AKT2(2), AKT3(3), ANGPTL2(4), ARHGAP4(2), ARHGEF11(12), BTK(2), CDC42(1), CFL1(1), GDI1(1), INPPL1(13), ITPR1(17), ITPR2(18), ITPR3(16), LIMK1(4), MYLK(9), MYLK2(3), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PDK1(1), PIK3CD(8), PIK3CG(10), PIK3R1(7), PITX2(2), PPP1R13B(6), PTEN(8), RACGAP1(2), RHO(2), ROCK1(7), ROCK2(3), SAG(1), WASF1(4), WASL(1)	13522993	194	61	192	69	72	56	11	31	24	0	0.22	1.00	1.00
310	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AIFM1(1), AKT1(2), AKT2(2), AKT3(3), APAF1(2), ATM(17), BAD(1), BCL2(1), BID(1), BIRC2(2), BIRC3(4), CAPN1(3), CAPN2(4), CASP10(3), CASP3(1), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CSF2RB(7), CYCS(1), DFFA(2), DFFB(2), ENDOG(1), FAS(3), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(3), IL3(1), IL3RA(4), IRAK1(5), IRAK2(4), IRAK3(2), IRAK4(3), MAP3K14(3), MYD88(2), NFKB1(5), NFKB2(3), NTRK1(4), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RELA(2), TNF(2), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(2), TNFRSF10D(2), TNFRSF1A(3), TNFSF10(2), TRAF2(2)	15937757	201	60	197	67	63	67	6	41	23	1	0.19	1.00	1.00
311	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(2), BMP4(6), BMP5(6), BMP6(5), BMP7(2), BMP8A(1), BMP8B(2), BTRC(3), CSNK1A1L(3), CSNK1D(2), CSNK1E(6), CSNK1G1(2), CSNK1G2(2), CSNK1G3(4), DHH(3), FBXW11(5), GLI1(9), GLI2(9), GLI3(16), GSK3B(2), HHIP(6), IHH(2), LRP2(36), PRKACA(1), PRKACB(2), PRKACG(3), PRKX(2), PTCH1(12), PTCH2(4), SMO(6), STK36(9), SUFU(3), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(5), WNT3A(1), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2)	11881399	218	60	215	77	84	58	8	43	25	0	0.21	1.00	1.00
312	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	63	APAF1(2), ATM(17), ATR(5), BAI1(7), BID(1), CASP3(1), CASP8(6), CASP9(1), CCNB1(1), CCNB2(1), CCNB3(7), CCND1(1), CCND2(1), CCND3(2), CCNE1(3), CCNE2(1), CCNG2(1), CD82(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(4), CHEK1(2), CHEK2(5), CYCS(1), DDB2(2), EI24(1), FAS(3), GTSE1(4), IGF1(2), IGFBP3(4), LRDD(4), MDM2(3), MDM4(3), PERP(2), PPM1D(4), PTEN(8), RFWD2(5), RPRM(3), RRM2(2), RRM2B(2), SERPINB5(3), SERPINE1(2), SESN1(1), SESN2(1), SESN3(2), SIAH1(1), STEAP3(5), THBS1(9), TNFRSF10B(2), TP73(5), TSC2(4), ZMAT3(2)	12741639	168	59	167	60	51	55	5	33	23	1	0.36	1.00	1.00
313	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(3), ADCY4(5), ADCY6(5), ADCY8(12), CACNA1A(11), CACNA1B(14), GNAS(14), GNAT3(2), GNB1(1), GNB3(1), GRM4(5), ITPR3(16), KCNB1(5), PDE1A(3), PLCB2(4), PRKACA(1), PRKACB(2), PRKACG(3), PRKX(2), SCNN1A(2), SCNN1B(5), SCNN1G(4), TAS1R1(5), TAS1R2(3), TAS1R3(5), TAS2R1(2), TAS2R10(2), TAS2R13(2), TAS2R16(3), TAS2R3(2), TAS2R38(3), TAS2R39(3), TAS2R4(2), TAS2R40(3), TAS2R41(1), TAS2R43(1), TAS2R46(1), TAS2R50(1), TAS2R60(3), TAS2R7(2), TAS2R8(1), TAS2R9(2), TRPM5(2)	11246597	169	59	167	79	57	57	7	38	10	0	0.85	1.00	1.00
314	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(2), CDC40(6), CLK2(6), CLK3(5), CLK4(3), COL2A1(8), CPSF1(11), CPSF2(2), CPSF3(2), CPSF4(2), CSTF1(4), CSTF2(4), CSTF2T(2), CSTF3(4), DDIT3(3), DDX1(3), DDX20(3), DHX15(8), DHX16(5), DHX38(7), DHX8(5), DHX9(1), DICER1(5), DNAJC8(1), GIPC1(2), METTL3(1), NCBP1(4), NUDT21(1), NXF1(3), PABPN1(2), PAPOLA(2), PHF5A(2), POLR2A(9), PPM1G(3), PRPF3(2), PRPF4(4), PRPF4B(9), PRPF8(10), PSKH1(4), PTBP1(4), PTBP2(1), RBM5(3), RNGTT(1), RNMT(3), RNPS1(1), SF3A1(2), SF3A2(1), SF3A3(2), SF3B1(4), SF3B2(6), SF3B4(3), SF4(6), SFRS12(3), SFRS14(6), SFRS16(2), SFRS4(3), SFRS5(4), SFRS6(5), SFRS7(2), SFRS8(7), SFRS9(1), SNRPA(5), SNRPA1(2), SNRPB(1), SNRPD1(3), SNRPD2(2), SNRPD3(1), SNRPE(1), SNRPG(1), SNRPN(4), SPOP(2), SRPK1(2), SRPK2(5), SRRM1(3), SUPT5H(7), U2AF1(2), U2AF2(3), XRN2(12)	20867834	286	59	285	92	105	80	18	56	27	0	0.20	1.00	1.00
315	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT1(2), AKT2(2), AKT3(3), BCR(7), BTK(2), CD19(1), CDKN2A(4), DAPP1(1), FLOT1(1), FLOT2(3), GAB1(1), ITPR1(17), ITPR2(18), ITPR3(16), LYN(4), NR0B2(2), PDK1(1), PHF11(2), PITX2(2), PLCG2(6), PPP1R13B(6), PREX1(9), PTEN(8), PTPRC(16), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KB1(3), SAG(1), SYK(3), TEC(3), VAV1(7)	10583051	165	59	164	64	56	46	6	37	20	0	0.51	1.00	1.00
316	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(2), AKT3(3), ANKRD6(3), APC(20), AXIN1(7), AXIN2(3), CER1(3), CTNNB1(11), DACT1(4), DKK1(5), DKK2(2), DKK3(1), DKK4(2), DVL1(4), GSK3A(1), GSK3B(2), LRP1(23), MVP(4), NKD1(6), NKD2(1), PIN1(1), PSEN1(1), PTPRA(5), SENP2(3), SFRP1(3), TSHB(1), WIF1(2)	7982080	125	59	123	49	42	39	2	25	15	2	0.59	1.00	1.00
317	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(1), ACADL(2), ACADM(1), ACOX1(2), ACOX2(4), ACOX3(5), ACSL1(2), ACSL3(6), ACSL4(3), ACSL5(2), ACSL6(5), ADIPOQ(2), ANGPTL4(2), APOA1(2), APOA5(5), AQP7(2), CD36(2), CPT1A(4), CPT1B(4), CPT1C(4), CPT2(4), CYP27A1(1), CYP4A11(1), CYP4A22(1), CYP7A1(3), CYP8B1(4), DBI(1), EHHADH(2), FABP2(1), FABP3(1), FABP5(2), FABP6(3), FABP7(1), FADS2(4), GK(2), GK2(1), HMGCS2(1), ILK(2), LPL(2), ME1(3), MMP1(2), NR1H3(2), OLR1(2), PCK1(4), PCK2(6), PDPK1(1), PLTP(3), PPARA(3), PPARD(5), PPARG(1), RXRA(3), RXRG(3), SCD(4), SCP2(3), SLC27A1(3), SLC27A2(2), SLC27A4(3), SLC27A5(6), SLC27A6(4), SORBS1(7), UBC(3)	12968549	170	58	170	47	62	40	11	41	16	0	0.015	1.00	1.00
318	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(4), ADAM17(3), ATP6AP1(4), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), CASP3(1), CCL5(1), CDC42(1), CSK(3), EGFR(10), GIT1(2), IGSF5(2), IKBKB(3), IL8(1), JAM3(3), JUN(2), LYN(4), MAP2K4(5), MAP3K14(3), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK8(4), MAPK9(3), MET(4), NFKB1(5), NFKB2(3), NOD1(7), PAK1(4), PLCG1(10), PLCG2(6), PTPN11(4), PTPRZ1(15), RELA(2), TCIRG1(4), TJP1(6)	13905064	173	58	172	77	43	57	6	47	20	0	0.88	1.00	1.00
319	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(2), AKT2(2), AKT3(3), BRD4(5), CAP1(2), CBL(2), CDC42(1), CDKN2A(4), F2RL2(1), FLOT1(1), FLOT2(3), GRB2(1), GSK3A(1), GSK3B(2), IGFBP1(2), INPPL1(13), IRS1(7), IRS2(3), IRS4(11), LNPEP(9), MAPK1(2), MAPK3(1), PARD3(8), PDK1(1), PIK3CD(8), PIK3R1(7), PPYR1(7), PTEN(8), RAF1(6), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KB1(3), SERPINB6(3), SHC1(3), SLC2A4(1), SORBS1(7), SOS1(4), SOS2(5), YWHAG(1), YWHAH(1), YWHAQ(2), YWHAZ(1)	11289730	168	58	165	60	66	54	2	24	22	0	0.24	1.00	1.00
320	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT1(2), AKT2(2), AKT3(3), BTK(2), FCER1A(1), FYN(5), GRB2(1), IL13(2), IL3(1), INPP5D(1), LCP2(7), LYN(4), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(13), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), MAPK9(3), NRAS(1), PDK1(1), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCG1(10), PLCG2(6), PRKCD(3), PRKCE(6), RAC2(1), RAC3(1), RAF1(6), SOS1(4), SOS2(5), SYK(3), TNF(2), VAV1(7), VAV2(8), VAV3(6)	13731132	206	57	204	76	63	75	3	46	19	0	0.34	1.00	1.00
321	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(13), ACSL1(2), ACSL3(6), ACSL4(3), ACSL5(2), ACSL6(5), ADIPOQ(2), ADIPOR1(2), ADIPOR2(2), AGRP(1), AKT1(2), AKT2(2), AKT3(3), CAMKK1(4), CAMKK2(1), CD36(2), CPT1A(4), CPT1B(4), CPT1C(4), CPT2(4), IKBKB(3), IRS1(7), IRS2(3), IRS4(11), JAK1(4), JAK2(8), JAK3(3), LEPR(8), MAPK10(3), MAPK8(4), MAPK9(3), NFKB1(5), NFKB2(3), NFKBIB(4), NPY(1), PCK1(4), PCK2(6), POMC(5), PPARA(3), PPARGC1A(6), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2), PRKAG3(3), PRKCQ(2), PTPN11(4), RELA(2), RXRA(3), RXRG(3), SLC2A1(3), SLC2A4(1), SOCS3(3), STAT3(7), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF2(2), TYK2(6)	16348424	217	57	217	88	73	55	6	55	27	1	0.68	1.00	1.00
322	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(4), CAD(7), CANT1(4), CDA(2), CTPS(2), CTPS2(2), DCK(1), DCTD(1), DHODH(1), DPYD(13), DPYS(2), DTYMK(1), DUT(1), ENTPD1(3), NT5C(1), NUDT2(2), POLD1(7), POLE(14), POLG(4), POLL(1), POLQ(14), POLR1B(2), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(9), RRM1(4), RRM2(2), TK1(2), TK2(3), TXNRD1(5), TYMS(1), UCK1(2), UCK2(1), UMPS(1), UNG(1), UPB1(2), UPP1(1)	11319087	140	57	140	59	41	45	7	30	17	0	0.68	1.00	1.00
323	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(4), APC(20), AXIN1(7), BMP10(2), BMP2(2), BMP4(6), BMP5(6), BMP7(2), BMPR1A(1), BMPR2(10), CHRD(1), CTNNB1(11), DVL1(4), FZD1(8), GATA4(3), GSK3B(2), MAP3K7(7), MEF2C(2), MYL2(1), NKX2-5(2), NPPA(1), NPPB(1), RFC1(1), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6), TGFBR3(2), WNT1(3)	7170285	130	56	126	45	35	33	5	34	19	4	0.55	1.00	1.00
324	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(20), AXIN1(7), CREBBP(13), CTNNB1(11), DVL1(4), EP300(15), FZD1(8), GSK3B(2), HDAC1(2), LDB1(5), LEF1(4), PITX2(2), TRRAP(27), WNT1(3)	6530618	123	56	121	51	43	27	3	24	24	2	0.77	1.00	1.00
325	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(2), AKT3(3), ASAH1(2), BRAF(5), DAG1(7), DRD2(6), EGFR(10), EPHB2(11), GRB2(1), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), KCNJ3(6), KCNJ5(2), MAPK1(2), PI3(2), PIK3CB(6), PITX2(2), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), RAF1(6), RGS20(2), SHC1(3), SOS1(4), SOS2(5), STAT3(7), TERF2IP(3)	11634546	189	56	186	70	63	61	6	36	22	1	0.38	1.00	1.00
326	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), AGK(2), AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPAT6(2), AKR1B1(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), CEL(6), DAK(3), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKI(5), DGKQ(2), DGKZ(1), GK(2), GK2(1), GLB1(3), GPAM(5), LCT(11), LIPA(2), LIPC(2), LIPF(1), LIPG(3), LPL(2), PNLIP(2), PNLIPRP1(3), PNLIPRP2(2), PNPLA3(2), PPAP2C(5)	11648621	149	55	148	55	37	56	3	35	18	0	0.27	1.00	1.00
327	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(4), ALPL(3), ALPP(5), ALPPL2(4), ASCC3(20), ATP13A2(7), DDX18(8), DDX19A(3), DDX23(6), DDX4(2), DDX41(7), DDX47(2), DDX50(3), DDX51(4), DDX54(6), DDX55(3), DDX56(4), DHX58(4), ENTPD7(8), EP400(19), ERCC2(4), ERCC3(3), FPGS(1), GGH(1), IFIH1(4), MOV10L1(4), NUDT5(1), NUDT8(1), QDPR(3), RAD54B(3), RAD54L(4), RUVBL2(3), SETX(11), SKIV2L2(3), SMARCA2(17), SMARCA5(1), SPR(2)	12409047	188	55	185	69	74	53	7	32	22	0	0.43	1.00	1.00
328	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(2), APOA1(2), CD36(2), CITED2(1), CPT1B(4), CREBBP(13), DUSP1(1), DUT(1), EHHADH(2), EP300(15), HSD17B4(2), HSPA1A(1), JUN(2), LPL(2), MAPK1(2), MAPK3(1), ME1(3), NCOA1(11), NCOR1(14), NCOR2(15), NR0B2(2), NR1H3(2), NR2F1(4), NRIP1(7), PDGFA(1), PIK3R1(7), PPARA(3), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PTGS2(2), RB1(8), RELA(2), RXRA(3), SP1(3), SRA1(1), STAT5A(1), STAT5B(4), TNF(2)	12053685	163	55	162	53	34	57	6	38	28	0	0.15	1.00	1.00
329	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(2), AKT2(2), AKT3(3), BAD(1), BCL2(1), BCR(7), BLNK(2), BTK(2), CD19(1), CD22(1), CD81(3), CR2(4), CSK(3), DAG1(7), FLOT1(1), FLOT2(3), GRB2(1), GSK3A(1), GSK3B(2), INPP5D(1), ITPR1(17), ITPR2(18), ITPR3(16), LYN(4), MAP4K1(2), MAPK1(2), MAPK3(1), NFATC1(9), NFATC2(8), NR0B2(2), PDK1(1), PIK3CD(8), PIK3R1(7), PLCG2(6), PPP1R13B(6), PPP3CA(3), PPP3CB(1), PTPRC(16), RAF1(6), SHC1(3), SOS1(4), SOS2(5), SYK(3), VAV1(7)	14271100	203	55	200	74	65	66	6	40	26	0	0.27	1.00	1.00
330	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(2), APC(20), AR(8), ASAH1(2), BRAF(5), CAMP(1), CCL15(1), DAG1(7), EGFR(10), GNA11(4), GNA15(2), GNAI1(1), GNAQ(1), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), KCNJ3(6), KCNJ5(2), MAPK1(2), MAPK10(3), MAPK14(1), PHKA2(7), PIK3CD(8), PIK3R1(7), PITX2(2), PTX3(1), RAF1(6)	10160510	167	55	165	62	54	44	11	36	20	2	0.37	1.00	1.00
331	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	ALG2(1), BAK1(2), BFAR(1), BTK(2), CAD(7), CASP10(3), CASP3(1), CASP8(6), CASP8AP2(9), CD7(4), DAXX(3), DEDD(1), DEDD2(2), DFFA(2), DIABLO(1), EGFR(10), EPHB2(11), FAF1(4), FAIM2(1), HSPB1(1), IL8(1), MAP2K4(5), MAP2K7(13), MAP3K1(8), MAP3K5(3), MAPK1(2), MAPK10(3), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3), MET(4), NFAT5(5), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), NR0B2(2), PFN2(2), PTPN13(14), RALBP1(7), ROCK1(7), SMPD1(4), TPX2(4), TRAF2(2), TUFM(3)	14339763	197	55	193	78	63	55	7	44	28	0	0.64	1.00	1.00
332	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(4), AASS(2), ACAT1(3), ACAT2(3), AKR1B10(1), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), BBOX1(1), DLST(1), DOT1L(9), EHHADH(2), EHMT1(7), EHMT2(4), GCDH(3), HADH(2), HADHA(2), HSD17B4(2), HSD3B7(3), NSD1(13), OGDH(8), OGDHL(3), PIPOX(3), PLOD1(6), PLOD2(3), PLOD3(4), RDH11(1), RDH12(1), SETD1A(7), SETDB1(12), SHMT1(1), SHMT2(4), SPCS3(1), SUV39H1(4), SUV39H2(1), TMLHE(4)	11447372	149	54	146	56	46	49	6	27	21	0	0.37	1.00	1.00
333	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	AKT1(2), AKT2(2), AKT3(3), BAD(1), CASP9(1), CDC42(1), KDR(7), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK3(3), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NOS3(3), NRAS(1), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCG1(10), PLCG2(6), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKCG(4), PTGS2(2), PTK2(7), PXN(2), RAC2(1), RAC3(1), RAF1(6), SH2D2A(2), SHC2(2), SPHK1(5)	13647313	187	54	184	71	61	65	8	34	19	0	0.30	1.00	1.00
334	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(1), AGT(2), AKT1(2), CALM1(1), CALM2(2), CALM3(1), CALR(4), CAMK1(1), CAMK1G(3), CAMK4(4), CREBBP(13), EDN1(3), ELSPBP1(1), F2(4), FGF2(2), GATA4(3), GSK3B(2), HAND1(3), HAND2(3), IGF1(2), LIF(2), MAP2K1(4), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(4), MEF2C(2), MYH2(14), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NKX2-5(2), NPPA(1), PIK3R1(7), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RAF1(6), RPS6KB1(3)	9560294	156	54	156	58	43	55	7	29	22	0	0.29	1.00	1.00
335	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	63	AGTR1(1), AGTR2(1), ATP8A1(7), AVPR1A(7), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(3), C3AR1(2), CCKAR(2), CCKBR(4), CCR1(2), CCR10(2), CCR2(3), CCR3(4), CCR5(1), CCR6(1), CCR8(2), CX3CR1(4), CXCR4(2), CXCR6(1), EDNRA(3), FPR1(1), GALR1(3), GALR2(1), GALR3(1), GALT(1), GHSR(4), GNRHR(3), GRPR(3), MC2R(2), MC3R(3), MC4R(4), MC5R(6), NMBR(1), NPY1R(2), NPY2R(1), NPY5R(1), NTSR1(4), OPRD1(3), OPRK1(4), OPRL1(2), OXTR(4), PPYR1(7), SSTR1(10), SSTR2(2), SSTR3(4), SSTR4(8), TAC4(1), TACR1(3), TACR2(2), TACR3(6), TRHR(6), TSHR(8)	9570342	166	54	164	54	62	57	2	34	11	0	0.016	1.00	1.00
336	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(2), AKT1(2), ANGPTL2(4), DAG1(7), DGKA(3), ETFA(1), GCA(3), ITGA9(9), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), MAP2K1(4), MAPK1(2), MAPK3(1), NR1I3(3), PAK1(4), PDE3A(8), PDE3B(10), PI3(2), PIK3C2G(3), PIK3CD(8), PIK3R1(7), RIPK3(2), SGCB(2), VASP(3)	9286838	148	54	147	46	45	44	10	29	19	1	0.084	1.00	1.00
337	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(3), AKT1(2), APC(20), ASAH1(2), CAMP(1), DAG1(7), DLG4(5), EPHB2(11), GNAI1(1), GNAQ(1), ITPR1(17), ITPR2(18), ITPR3(16), KCNJ3(6), KCNJ5(2), MAPK1(2), PITX2(2), PTX3(1), RHO(2), RYR1(33)	9135416	152	54	148	62	63	33	8	27	20	1	0.56	1.00	1.00
338	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(2), CSK(3), CTLA4(3), DAG1(7), DTYMK(1), EPHB2(11), FBXW7(11), GRAP2(1), GRB2(1), ITK(4), ITPKA(1), ITPKB(6), LCK(1), LCP2(7), MAPK1(2), NCK1(3), NFAT5(5), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PLCG1(10), PTPRC(16), RAF1(6), RASGRP1(4), RASGRP2(4), RASGRP3(2), RASGRP4(3), SOS1(4), SOS2(5), VAV1(7), ZAP70(4)	11069594	172	54	165	63	48	46	5	43	29	1	0.57	1.00	1.00
339	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(6), AGMAT(2), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH4A1(2), ALDH9A1(4), AMD1(2), AOC2(4), AOC3(3), ARG1(2), ASL(5), CKB(1), CKMT1A(2), CKMT1B(3), CKMT2(6), CPS1(15), DAO(5), GATM(2), GLUD1(4), GOT1(2), GOT2(3), MAOA(1), MAOB(3), NOS1(16), NOS3(3), ODC1(3), OTC(2), P4HA1(1), P4HA2(6), P4HA3(1), P4HB(4), PYCR1(2), RARS(2), SMS(2)	8734139	147	53	146	41	51	39	5	37	14	1	0.038	1.00	1.00
340	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	ACTG1(2), APAF1(2), BAG4(2), BCL2(1), BID(1), BIRC2(2), BIRC3(4), CASP2(3), CASP3(1), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), DAXX(3), DFFA(2), DFFB(2), GSN(5), LMNA(5), LMNB1(2), LMNB2(3), MAP2K7(13), MAP3K1(8), MAP3K14(3), MAP3K5(3), MAPK8(4), MDM2(3), NFKB1(5), NUMA1(14), PAK2(5), PRKCD(3), PRKDC(22), PSEN1(1), PSEN2(2), PTK2(7), RB1(8), RELA(2), SPTAN1(13), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF1(2), TRAF2(2)	13382706	177	53	175	58	55	56	8	33	25	0	0.16	1.00	1.00
341	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(4), B3GALNT1(2), B3GALT1(2), B3GALT2(5), B3GALT4(3), B3GALT5(1), B3GNT1(1), B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(1), B4GALNT1(2), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), B4GALT6(2), FUT1(2), FUT4(1), FUT7(1), FUT9(3), GCNT2(2), PIGA(2), PIGB(4), PIGC(2), PIGG(5), PIGK(1), PIGL(1), PIGM(4), PIGN(3), PIGO(1), PIGQ(2), PIGS(1), PIGT(3), PIGV(3), PIGX(2), PIGZ(2), ST3GAL1(3), ST3GAL2(4), ST3GAL3(2), ST3GAL4(3), ST3GAL5(1), ST3GAL6(2), ST6GALNAC3(3), ST6GALNAC4(2), ST6GALNAC5(1), ST6GALNAC6(3), ST8SIA1(4), ST8SIA5(2)	9591689	114	53	113	45	40	33	5	29	6	1	0.49	1.00	1.00
342	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(2), AKT2(2), AKT3(3), BCL10(1), BLNK(2), BTK(2), CARD11(12), CD19(1), CD22(1), CD72(1), CD79A(6), CD81(3), CR2(4), FCGR2B(1), GSK3B(2), IFITM1(1), IKBKB(3), INPP5D(1), JUN(2), LILRB3(2), LYN(4), MALT1(5), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NFKB1(5), NFKB2(3), NFKBIB(4), NRAS(1), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLCG2(6), PPP3CA(3), PPP3CB(1), PPP3R2(1), PTPN6(3), RAC2(1), RAC3(1), RASGRP3(2), SYK(3), VAV1(7), VAV2(8), VAV3(6)	14220549	194	53	191	83	63	70	3	35	23	0	0.66	1.00	1.00
343	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(6), AGXT(1), AGXT2(6), ALAS1(2), ALAS2(4), AMT(4), AOC2(4), AOC3(3), BHMT(5), CBS(3), CHDH(4), CHKA(1), CHKB(3), CPT1B(4), CTH(2), DAO(5), DLD(2), DMGDH(5), GARS(1), GATM(2), GCAT(3), GLDC(5), MAOA(1), MAOB(3), PEMT(1), PISD(4), PLCB2(4), PLCG1(10), PLCG2(6), PSPH(2), SARDH(4), SARS(4), SHMT1(1), SHMT2(4), TARS(6)	8303360	125	52	124	49	37	30	9	35	13	1	0.64	1.00	1.00
344	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(7), AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPAT6(2), CDS1(4), CDS2(1), CHAT(1), CHKA(1), CHKB(3), CHPT1(1), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKI(5), DGKQ(2), DGKZ(1), ESCO2(2), ETNK2(2), GNPAT(1), GPAM(5), GPD1(3), GPD1L(3), GPD2(3), LCAT(1), LYPLA2(1), MYST3(11), MYST4(15), NAT6(2), PCYT1A(7), PCYT1B(3), PEMT(1), PISD(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLD1(7), PLD2(11), PNPLA3(2), PPAP2C(5), PTDSS1(1), PTDSS2(2), SH3GLB1(1)	12927296	172	52	171	65	59	56	8	36	13	0	0.31	1.00	1.00
345	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	43	AKT1(2), AKT2(2), AKT3(3), BRAF(5), EIF4B(2), EIF4EBP1(1), HIF1A(2), IGF1(2), MAPK1(2), MAPK3(1), PDPK1(1), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PRKAA1(1), PRKAA2(3), RHEB(1), RICTOR(8), RPS6(1), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA6(7), RPS6KB1(3), RPS6KB2(3), TSC1(4), TSC2(4), ULK1(11), ULK2(4), ULK3(2), VEGFC(3)	10070375	134	52	133	59	51	41	6	24	12	0	0.79	1.00	1.00
346	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	48	ABL1(2), ACTB(4), ACTG1(2), ARHGEF2(5), CD14(1), CDC42(1), CLDN1(1), CTNNB1(11), CTTN(2), FYN(5), HCLS1(1), ITGB1(4), KRT18(3), LY96(1), NCK1(3), NCK2(2), NCL(7), OCLN(1), ROCK1(7), ROCK2(3), TLR5(4), TUBA1B(1), TUBA1C(2), TUBA3C(6), TUBA3D(5), TUBA3E(5), TUBA8(3), TUBAL3(3), TUBB1(4), TUBB2A(2), TUBB2C(2), TUBB3(8), TUBB4(1), TUBB4Q(2), TUBB6(5), TUBB8(2), WASL(1), YWHAQ(2), YWHAZ(1)	9664047	125	52	122	58	43	40	3	28	11	0	0.84	1.00	1.00
347	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	48	ABL1(2), ACTB(4), ACTG1(2), ARHGEF2(5), CD14(1), CDC42(1), CLDN1(1), CTNNB1(11), CTTN(2), FYN(5), HCLS1(1), ITGB1(4), KRT18(3), LY96(1), NCK1(3), NCK2(2), NCL(7), OCLN(1), ROCK1(7), ROCK2(3), TLR5(4), TUBA1B(1), TUBA1C(2), TUBA3C(6), TUBA3D(5), TUBA3E(5), TUBA8(3), TUBAL3(3), TUBB1(4), TUBB2A(2), TUBB2C(2), TUBB3(8), TUBB4(1), TUBB4Q(2), TUBB6(5), TUBB8(2), WASL(1), YWHAQ(2), YWHAZ(1)	9664047	125	52	122	58	43	40	3	28	11	0	0.84	1.00	1.00
348	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	23	ATM(17), BMPR1B(3), CCND2(1), DMC1(1), EGR1(3), ESR2(6), GJA4(4), INHA(2), MLH1(3), MSH5(5), NCOR1(14), NR5A1(5), NRIP1(7), PGR(7), PRLR(2), PTGER2(2), SMPD1(4), VDR(5), ZP2(5)	6379472	96	52	94	31	28	32	3	20	12	1	0.23	1.00	1.00
349	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(20), AXIN1(7), BTRC(3), CCND1(1), CREBBP(13), CSNK1D(2), CSNK2A1(4), CTBP1(2), CTNNB1(11), DVL1(4), FZD1(8), GSK3B(2), HDAC1(2), MAP3K7(7), NLK(5), PPARD(5), PPP2CA(3), TLE1(3), WIF1(2), WNT1(3)	5795793	107	52	104	38	32	27	5	19	22	2	0.46	1.00	1.00
350	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), AGPAT1(1), AGPAT3(2), AGPAT4(5), AKR1B1(5), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), CEL(6), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKQ(2), DGKZ(1), GK(2), GLB1(3), LCT(11), LIPC(2), LIPF(1), LIPG(3), LPL(2), PNLIP(2), PNLIPRP1(3), PNLIPRP2(2), PPAP2C(5)	9570515	134	51	133	55	36	47	2	32	17	0	0.53	1.00	1.00
351	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(8), GABBR1(8), GPRC5A(1), GPRC5B(4), GPRC5C(3), GPRC5D(1), GRM1(17), GRM2(11), GRM3(5), GRM4(5), GRM5(14), GRM7(12), GRM8(11)	4137303	100	51	100	36	44	20	5	24	7	0	0.25	1.00	1.00
352	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(3), ACTN2(15), ACTN3(2), BCAR1(4), BCR(7), CAPN1(3), CAPNS1(1), CAPNS2(1), CAV1(2), CSK(3), FYN(5), GRB2(1), ITGA1(4), ITGB1(4), JUN(2), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MAPK8(4), PPP1R12B(7), PTK2(7), PXN(2), RAF1(6), RAP1A(2), ROCK1(7), SHC1(3), SOS1(4), TLN1(13), VCL(2), ZYX(2)	9283378	125	51	123	53	41	38	5	29	12	0	0.71	1.00	1.00
353	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(6), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH3A1(5), ALDH3B2(4), AOC2(4), AOC3(3), AOX1(3), COMT(3), DBH(2), DCT(7), DDC(3), FAH(2), GOT1(2), GOT2(3), GSTZ1(3), HGD(2), HPD(1), MAOA(1), MAOB(3), PNMT(3), TAT(1), TH(1), TPO(13), TYR(5)	6275275	108	51	107	35	30	29	1	34	12	2	0.25	1.00	1.00
354	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(9), CARM1(2), CCND1(1), CREBBP(13), EP300(15), ERCC3(3), ESR1(5), GRIP1(8), GTF2A1(2), GTF2E1(5), GTF2F1(2), HDAC1(2), HDAC2(4), HDAC3(4), HDAC4(7), HDAC5(4), HDAC6(3), MEF2C(2), NCOR2(15), NR0B1(2), NRIP1(7), PELP1(6), POLR2A(9), SRA1(1), TBP(3)	9068427	134	50	132	46	40	35	6	29	24	0	0.30	1.00	1.00
355	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(7), ACSS2(3), ACYP2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH3B2(4), ALDH9A1(4), ALDOB(4), ALDOC(3), BPGM(1), DLAT(6), DLD(2), ENO1(3), ENO2(1), ENO3(3), FBP1(1), FBP2(3), GALM(1), GAPDH(1), GAPDHS(2), GCK(3), GPI(4), HK1(6), HK2(6), HK3(3), LDHAL6B(2), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKL(7), PFKM(3), PFKP(8), PGAM2(2), PGAM4(1), PGK1(1), PGK2(1), PGM1(3), PGM3(6), PKLR(4), PKM2(2), TPI1(2)	11496083	167	50	166	64	51	52	7	41	16	0	0.37	1.00	1.00
356	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(2), AARS2(5), ABAT(4), ACY3(1), ADSL(4), ADSS(3), ADSSL1(7), AGXT(1), AGXT2(6), ASL(5), ASNS(4), ASRGL1(1), ASS1(6), CAD(7), CRAT(3), DARS(2), DDO(2), DLAT(6), DLD(2), GAD1(3), GAD2(4), GOT1(2), GOT2(3), GPT(1), GPT2(3), NARS(3), NARS2(1), PC(6), PDHA1(1), PDHA2(4), PDHB(2)	7476091	104	50	102	39	44	26	2	26	6	0	0.46	1.00	1.00
357	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(4), AANAT(1), ABP1(6), ACAT1(3), ACAT2(3), ACMSD(2), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), AOC2(4), AOC3(3), AOX1(3), ASMT(2), CARM1(2), CAT(4), CYP1A1(3), CYP1A2(3), CYP1B1(2), DDC(3), EHHADH(2), GCDH(3), HADH(2), HADHA(2), HSD17B4(2), INMT(1), KYNU(6), LCMT1(1), LCMT2(7), LNX1(4), MAOA(1), MAOB(3), METTL6(1), NFX1(2), OGDH(8), OGDHL(3), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), TDO2(3), TPH1(1), TPH2(4), WARS(3), WARS2(5), WBSCR22(2)	11978322	152	50	147	48	38	49	8	32	23	2	0.094	1.00	1.00
358	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(13), COL4A2(7), COL4A3(4), COL4A4(7), COL4A5(5), COL4A6(7), F10(3), F11(3), F12(2), F2(4), F2R(2), F5(9), F8(13), F9(4), FGA(5), FGB(3), FGG(2), KLKB1(4), PROC(3), PROS1(6), SERPINC1(2), SERPING1(6)	8833521	114	50	113	40	24	39	4	35	12	0	0.36	1.00	1.00
359	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(9), ATP4A(5), ATP4B(2), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5G3(1), ATP5J(1), ATP5J2(1), ATP5L(1), ATP6AP1(4), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), COX10(1), COX15(3), COX4I1(4), COX4I2(1), COX6B1(1), COX7A2(2), COX7C(1), LHPP(3), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA3(1), NDUFA6(1), NDUFA8(1), NDUFA9(2), NDUFAB1(1), NDUFB2(1), NDUFB7(1), NDUFB8(1), NDUFB9(1), NDUFC2(2), NDUFS1(5), NDUFS2(2), NDUFS5(1), NDUFS6(1), NDUFS7(1), NDUFS8(3), NDUFV1(1), PPA2(2), SDHA(5), SDHB(4), SDHC(1), TCIRG1(4), UQCRB(1), UQCRC1(2), UQCRC2(2), UQCRFS1(1), UQCRQ(1)	11013913	135	49	135	65	37	50	8	32	8	0	0.92	1.00	1.00
360	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(4), ADC(1), ALDH4A1(2), ALDH5A1(3), CAD(7), CPS1(15), EARS2(2), EPRS(6), GAD1(3), GAD2(4), GCLM(2), GFPT1(3), GFPT2(3), GLS(4), GLS2(5), GLUD1(4), GLUD2(7), GLUL(2), GMPS(3), GOT1(2), GOT2(3), GPT(1), GPT2(3), GSR(4), GSS(1), NADSYN1(5), NAGK(1), PPAT(1), QARS(5)	7823866	106	49	104	38	38	33	6	24	5	0	0.35	1.00	1.00
361	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(6), AGXT(1), AGXT2(6), AKR1B10(1), ALAS1(2), ALAS2(4), AMT(4), AOC2(4), AOC3(3), BHMT(5), CBS(3), CHDH(4), CHKA(1), CHKB(3), CTH(2), DAO(5), DLD(2), DMGDH(5), GARS(1), GATM(2), GCAT(3), GLDC(5), GNMT(2), HSD3B7(3), MAOA(1), MAOB(3), PEMT(1), PHGDH(1), PIPOX(3), PISD(4), PSAT1(2), PSPH(2), RDH11(1), RDH12(1), SARDH(4), SARS(4), SARS2(3), SDS(1), SHMT1(1), SHMT2(4), TARS(6), TARS2(6)	8434837	125	49	125	48	41	29	10	32	12	1	0.54	1.00	1.00
362	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(15), ACACB(13), ACAT1(3), ACAT2(3), ACOT12(4), ACSS1(7), ACSS2(3), ACYP2(1), AKR1B1(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), DLAT(6), DLD(2), GRHPR(2), HAGH(2), LDHAL6B(2), LDHB(2), LDHC(1), LDHD(2), MDH1(3), MDH2(1), ME1(3), ME2(4), ME3(5), PC(6), PCK1(4), PCK2(6), PDHA1(1), PDHA2(4), PDHB(2), PKLR(4), PKM2(2)	9230719	142	49	142	40	44	38	7	35	18	0	0.039	1.00	1.00
363	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(3), CREBBP(13), CTBP1(2), CTBP2(4), DLL1(3), DLL3(2), DLL4(1), DTX1(7), DTX2(2), DTX3L(1), DTX4(4), DVL1(4), DVL2(3), DVL3(5), EP300(15), HDAC1(2), HDAC2(4), JAG1(4), JAG2(1), MAML1(4), MAML2(7), MAML3(7), NCOR2(15), NCSTN(3), NOTCH1(15), NOTCH2(16), NOTCH3(10), NOTCH4(7), NUMB(2), NUMBL(3), PSEN1(1), PSEN2(2), PSENEN(1), PTCRA(1), RBPJ(2), RBPJL(3), RFNG(1)	13532733	180	49	176	81	63	50	7	33	27	0	0.77	1.00	1.00
364	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(1), DAXX(3), EGF(5), EGFR(10), ETS1(4), ETS2(1), HOXA7(2), IKBKB(3), JUN(2), MAP2K1(4), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(13), MAP3K1(8), MAP3K14(3), MAP3K5(3), MAPK1(2), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), NFKB1(5), PPP2CA(3), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCQ(2), RAF1(6), RELA(2), SP1(3), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF2(2)	9707027	126	49	125	50	42	35	2	30	17	0	0.49	1.00	1.00
365	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	33	ACTA1(1), CRK(1), DOCK1(12), ELK1(2), GAB1(1), GRB2(1), HGF(11), ITGA1(4), ITGB1(4), JUN(2), MAP2K1(4), MAP2K2(1), MAP4K1(2), MAPK1(2), MAPK3(1), MAPK8(4), MET(4), PAK1(4), PIK3R1(7), PTEN(8), PTK2(7), PTK2B(8), PTPN11(4), PXN(2), RAF1(6), RAP1A(2), RAP1B(4), SOS1(4), STAT3(7)	7963342	120	49	117	48	28	39	4	29	20	0	0.68	1.00	1.00
366	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(23), B3GALT4(3), CDR1(4), DGKI(5), IL6ST(2), PIGK(1), RPL10(2), RPL12(1), RPL13(1), RPL13A(1), RPL14(1), RPL18A(1), RPL19(2), RPL27A(1), RPL3(2), RPL31(1), RPL34(1), RPL36(1), RPL5(1), RPL6(1), RPL7A(3), RPL8(2), RPL9(2), RPLP0(3), RPLP1(1), RPS10(1), RPS11(1), RPS13(1), RPS14(2), RPS20(1), RPS23(1), RPS27A(1), RPS3(1), RPS3A(1), RPS5(2), RPS6(1), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA6(7), RPS6KB1(3), RPS6KB2(3), RPSA(4), SLC36A2(4), TBC1D10C(1), TSPAN9(1), UBC(3)	10334264	119	49	119	49	28	42	7	31	10	1	0.81	1.00	1.00
367	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(2), AKT2(2), AKT3(3), BAD(1), BCR(7), BLNK(2), BTK(2), CD19(1), CSK(3), DAG1(7), EPHB2(11), GRB2(1), ITPKA(1), ITPKB(6), LYN(4), MAP2K1(4), MAP2K2(1), MAPK1(2), NFAT5(5), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PI3(2), PIK3CD(8), PIK3R1(7), PLCG2(6), PPP1R13B(6), RAF1(6), SERPINA4(2), SHC1(3), SOS1(4), SOS2(5), SYK(3), VAV1(7)	9986261	142	49	138	46	41	48	2	25	25	1	0.21	1.00	1.00
368	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(8), AMY2A(2), AMY2B(4), ENPP1(1), ENPP3(3), GAA(2), GANAB(3), GBA3(1), GBE1(4), GCK(3), GPI(4), GUSB(3), GYS1(4), GYS2(2), HK1(6), HK2(6), HK3(3), MGAM(7), PGM1(3), PGM3(6), PYGB(4), PYGL(5), PYGM(7), SI(11), UCHL1(2), UCHL3(3), UGDH(4), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2B15(1), UGT2B4(2), UXS1(3)	11343467	122	49	122	43	35	45	4	19	19	0	0.27	1.00	1.00
369	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(2), APC(20), AXIN1(7), CCND1(1), CD14(1), CTNNB1(11), DVL1(4), FZD1(8), GJA1(8), GNAI1(1), GSK3B(2), IRAK1(5), LEF1(4), LY96(1), MYD88(2), NFKB1(5), PDPK1(1), PIK3R1(7), PPP2CA(3), RELA(2), TIRAP(2), TOLLIP(1), WNT1(3)	5284000	101	48	99	35	25	28	5	22	19	2	0.40	1.00	1.00
370	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(3), INPPL1(13), ITPKA(1), ITPKB(6), MIOX(1), OCRL(4), PIK3C2A(4), PIK3C2B(12), PIK3C2G(3), PIK3CB(6), PIK3CG(10), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLCD1(1), PLCG1(10), PLCG2(6)	8478949	123	48	121	39	38	43	2	27	12	1	0.22	1.00	1.00
371	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(3), ALOX12(4), ALOX15(2), ALOX5(6), CBR1(1), CBR3(3), CYP4F2(4), CYP4F3(3), EPX(4), GGT1(8), LPO(2), LTA4H(4), MPO(5), PLA2G1B(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PRDX6(1), PTGES2(4), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(2), TPO(13)	5493529	96	48	94	31	35	23	4	25	9	0	0.23	1.00	1.00
372	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(6), AKT1(2), AKT2(2), AKT3(3), DAG1(7), GNAQ(1), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PDK1(1), PHKA2(7), PIK3CB(6), PITX2(2), PLD1(7), PLD2(11), PLD3(5), VN1R1(3)	8914753	139	48	139	50	44	43	9	30	12	1	0.31	1.00	1.00
373	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(2), CDC42(1), DLD(2), DUSP10(3), DUSP4(1), DUSP8(1), GAB1(1), GCK(3), IL1R1(3), JUN(2), MAP2K4(5), MAP2K5(1), MAP2K7(13), MAP3K1(8), MAP3K10(6), MAP3K11(3), MAP3K12(4), MAP3K13(5), MAP3K2(2), MAP3K3(2), MAP3K4(10), MAP3K5(3), MAP3K7(7), MAP3K9(5), MAPK10(3), MAPK7(8), MAPK8(4), MAPK9(3), MYEF2(4), NFATC3(3), NR2C2(3), PAPPA(14), SHC1(3), TRAF6(4), ZAK(3)	9787603	145	48	145	45	44	46	7	27	21	0	0.12	1.00	1.00
374	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(5), EEF1B2(1), EEF1D(4), EEF1G(3), EEF2(3), EEF2K(8), EIF1AX(1), EIF1AY(1), EIF2AK1(4), EIF2AK2(2), EIF2AK3(8), EIF2B1(3), EIF2B3(3), EIF2B4(6), EIF2B5(4), EIF2S1(1), EIF2S2(2), EIF2S3(1), EIF4A1(2), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4EBP2(1), EIF4G1(10), EIF4G3(5), EIF5(3), EIF5A(3), EIF5B(6), ETF1(3), GSPT2(1), KIAA0664(9), PABPC1(3), PABPC3(5), PAIP1(1), SLC35A4(4)	8640782	121	48	119	47	42	41	4	26	8	0	0.48	1.00	1.00
375	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(2), BAD(1), BCL2(1), CASP1(2), CASP10(3), CASP2(3), CASP3(1), CASP4(2), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CD40(1), CD40LG(4), CYCS(1), DAXX(3), DFFA(2), DFFB(2), FAS(3), IKBKE(5), LTA(2), NFKB1(5), NGFR(5), NR3C1(5), NTRK1(4), PTPN13(14), SFRS2IP(5), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF1(2), TRAF2(2), TRAF3(2), TRAF6(4)	8656801	102	47	102	43	23	33	8	29	9	0	0.76	1.00	1.00
376	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(3), CASP3(1), CASP6(1), CASP7(2), CASP8(6), DAXX(3), DFFA(2), DFFB(2), FAF1(4), JUN(2), LMNA(5), LMNB1(2), LMNB2(3), MAP2K4(5), MAP3K1(8), MAP3K7(7), MAPK8(4), PAK1(4), PAK2(5), PRKDC(22), PTPN13(14), RB1(8), RIPK2(2), SPTAN1(13)	8240878	128	47	127	38	29	44	5	28	22	0	0.15	1.00	1.00
377	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(6), ALDH1A3(6), ALDH3A1(5), ALDH3B2(4), AOC2(4), AOC3(3), DDC(3), EPX(4), ESCO2(2), GOT1(2), GOT2(3), HPD(1), LPO(2), MAOA(1), MAOB(3), MPO(5), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), PRDX6(1), SH3GLB1(1), TAT(1), TPO(13)	6770098	100	47	100	30	29	26	4	31	9	1	0.18	1.00	1.00
378	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(3), ALOX12(4), ALOX12B(3), ALOX15(2), ALOX15B(1), ALOX5(6), CBR1(1), CBR3(3), CYP2B6(2), CYP2C18(5), CYP2C19(6), CYP2C9(1), CYP2E1(5), CYP2J2(2), CYP2U1(2), CYP4A11(1), CYP4A22(1), CYP4F2(4), CYP4F3(3), DHRS4(1), EPHX2(4), GGT1(8), GPX1(1), GPX3(1), GPX4(3), GPX6(2), GPX7(3), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PTGES2(4), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(2)	7669748	121	47	119	31	43	32	5	31	10	0	0.018	1.00	1.00
379	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), AKR1C1(1), AKR1C3(3), AKR1C4(3), ALDH1A3(6), ALDH3A1(5), ALDH3B2(4), CYP1A1(3), CYP1A2(3), CYP1B1(2), CYP2B6(2), CYP2C18(5), CYP2C19(6), CYP2C9(1), CYP2E1(5), CYP2F1(1), CYP2S1(3), CYP3A4(1), CYP3A43(3), CYP3A5(1), CYP3A7(2), DHDH(5), EPHX1(3), GSTA1(2), GSTA2(1), GSTA4(1), GSTA5(1), GSTM1(1), GSTM3(1), GSTM4(1), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(3), MGST1(2), MGST2(1), MGST3(1), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2)	11152074	135	47	134	47	33	47	2	36	17	0	0.28	1.00	1.00
380	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	41	AKT1(2), ASAH1(2), BRAF(5), CAMP(1), CREB1(4), CREB3(3), CREB5(2), CREBBP(13), DAG1(7), EGR1(3), EGR2(3), EGR3(1), EGR4(4), ELK1(2), FRS2(4), GNAQ(1), JUN(2), MAP1B(9), MAP2K4(5), MAP2K7(13), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3), NTRK1(4), OPN1LW(4), PIK3C2G(3), PIK3CD(8), PIK3R1(7), PTPN11(4), RPS6KA3(1), SHC1(3), TERF2IP(3), TH(1)	9699067	148	47	147	61	51	43	2	28	24	0	0.61	1.00	1.00
381	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	BAG4(2), CASP2(3), CASP3(1), CASP8(6), DFFA(2), DFFB(2), JUN(2), LMNA(5), LMNB1(2), LMNB2(3), MADD(6), MAP2K4(5), MAP3K1(8), MAP3K7(7), MAPK8(4), PAK1(4), PAK2(5), PRKDC(22), RB1(8), SPTAN1(13), TNF(2), TNFRSF1A(3), TRAF2(2)	7763758	117	47	116	37	32	38	5	24	18	0	0.17	1.00	1.00
382	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(7), AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPS(3), CDS1(4), CDS2(1), CHAT(1), CHKA(1), CHKB(3), CLC(2), CPT1B(4), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKQ(2), DGKZ(1), GNPAT(1), GPD1(3), GPD2(3), LCAT(1), LYPLA2(1), PAFAH1B1(3), PAFAH2(1), PCYT1A(7), PCYT1B(3), PEMT(1), PISD(4), PLA2G1B(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCB2(4), PLCG1(10), PLCG2(6), PPAP2C(5)	9881640	127	46	125	47	50	39	3	25	10	0	0.28	1.00	1.00
383	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(7), BLNK(2), ELK1(2), GRB2(1), JUN(2), LYN(4), MAP2K1(4), MAP3K1(8), MAPK1(2), MAPK3(1), MAPK8IP3(9), PAPPA(14), RPS6KA1(6), RPS6KA3(1), SHC1(3), SOS1(4), SYK(3), VAV1(7), VAV2(8), VAV3(6)	6331828	94	46	94	40	28	31	3	19	13	0	0.70	1.00	1.00
384	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(3), ACTN2(15), ACTN3(2), CAPN1(3), CAPNS1(1), CAPNS2(1), ITGA1(4), ITGB1(4), ITGB3(5), PTK2(7), PXN(2), SPTAN1(13), TLN1(13)	5635503	74	46	72	38	31	18	4	15	6	0	0.89	1.00	1.00
385	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(2), AGTR2(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CDK5(2), F2(4), FYN(5), GNA11(4), GNAI1(1), GNB1(1), GNGT1(3), GRB2(1), JAK2(8), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(4), MAPT(4), MYLK(9), PLCG1(10), PTK2B(8), RAF1(6), SHC1(3), SOS1(4), STAT1(6), STAT3(7), STAT5A(1)	8239967	114	45	113	40	36	40	4	23	11	0	0.30	1.00	1.00
386	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(3), F11(3), F12(2), F13B(8), F2(4), F5(9), F7(6), F8(13), F9(4), FGA(5), FGB(3), FGG(2), LPA(11), PLAT(2), PLAU(2), PLG(10), SERPINB2(3), SERPINE1(2), SERPINF2(6), VWF(13)	6987063	111	45	111	33	32	33	5	28	13	0	0.12	1.00	1.00
387	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), ELK1(2), FPR1(1), GNA15(2), GNB1(1), GNGT1(3), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K6(2), MAP3K1(8), MAPK1(2), MAPK14(1), MAPK3(1), NCF1(2), NCF2(1), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NFKB1(5), PAK1(4), PIK3C2G(3), PLCB1(12), PPP3CA(3), PPP3CB(1), RAF1(6), RELA(2)	7583960	107	45	107	35	32	34	2	24	15	0	0.22	1.00	1.00
388	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH3B2(4), ALDH9A1(4), ALDOB(4), ALDOC(3), BPGM(1), DLAT(6), DLD(2), ENO1(3), ENO2(1), ENO3(3), FBP1(1), FBP2(3), GAPDH(1), GCK(3), GPI(4), HK1(6), HK2(6), HK3(3), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKM(3), PFKP(8), PGK1(1), PGM1(3), PGM3(6), PKLR(4), PKM2(2), TPI1(2)	9649021	148	45	147	58	42	45	5	41	15	0	0.51	1.00	1.00
389	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH3B2(4), ALDH9A1(4), ALDOB(4), ALDOC(3), BPGM(1), DLAT(6), DLD(2), ENO1(3), ENO2(1), ENO3(3), FBP1(1), FBP2(3), GAPDH(1), GCK(3), GPI(4), HK1(6), HK2(6), HK3(3), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKM(3), PFKP(8), PGK1(1), PGM1(3), PGM3(6), PKLR(4), PKM2(2), TPI1(2)	9649021	148	45	147	58	42	45	5	41	15	0	0.51	1.00	1.00
390	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), AARS2(5), CARS(4), CARS2(2), DARS(2), EARS2(2), EPRS(6), FARS2(7), FARSA(3), FARSB(1), GARS(1), HARS(4), HARS2(3), IARS(7), IARS2(3), KARS(3), LARS(3), LARS2(5), MARS(3), MARS2(1), NARS(3), NARS2(1), PARS2(1), QARS(5), RARS(2), RARS2(2), SARS(4), SARS2(3), TARS(6), TARS2(6), VARS(8), VARS2(4), WARS(3), WARS2(5), YARS(1), YARS2(1)	10745285	122	45	121	47	42	42	3	29	6	0	0.62	1.00	1.00
391	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(2), ACTG2(6), ACTR2(2), AKT1(2), ANGPTL2(4), CDC42(1), CFL1(1), FLNA(11), FLNC(21), FSCN1(5), FSCN3(8), GDI1(1), LIMK1(4), MYH2(14), MYLK(9), MYLK2(3), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PFN2(2), RHO(2), ROCK1(7), ROCK2(3), VASP(3), WASF1(4), WASL(1)	9459217	136	45	136	49	52	43	5	24	12	0	0.14	1.00	1.00
392	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	32	A1BG(1), AKT1(2), AKT2(2), AKT3(3), BAD(1), BTK(2), CDKN2A(4), DAPP1(1), GRB2(1), GSK3A(1), GSK3B(2), IARS(7), IGFBP1(2), INPP5D(1), PDK1(1), PPP1R13B(6), PTEN(8), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KB1(3), SHC1(3), SOS1(4), SOS2(5), TEC(3), YWHAG(1), YWHAH(1), YWHAQ(2), YWHAZ(1)	6702522	82	45	82	34	21	31	0	18	12	0	0.71	1.00	1.00
393	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(6), ACAT1(3), ACAT2(3), ACMSD(2), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), AOC2(4), AOC3(3), AOX1(3), ASMT(2), CAT(4), CYP19A1(5), CYP1A1(3), CYP1A2(3), CYP2A13(4), CYP2A6(2), CYP2A7(3), CYP2B6(2), CYP2C18(5), CYP2C19(6), CYP2C9(1), CYP2D6(3), CYP2E1(5), CYP2F1(1), CYP2J2(2), CYP3A4(1), CYP3A5(1), CYP3A7(2), CYP4B1(1), CYP4F8(2), CYP51A1(3), DDC(3), EHHADH(2), GCDH(3), HADHA(2), KYNU(6), MAOA(1), MAOB(3), SDS(1), TDO2(3), TPH1(1), WARS(3), WARS2(5)	10898594	151	45	148	49	45	47	5	34	18	2	0.13	1.00	1.00
394	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	64	APAF1(2), BAD(1), BAK1(2), BCL2(1), BCL2L11(1), BID(1), BIRC2(2), BIRC3(4), BIRC5(1), CASP1(2), CASP10(3), CASP2(3), CASP3(1), CASP4(2), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), DFFA(2), DFFB(2), FAS(3), HELLS(3), IKBKB(3), IRF1(1), IRF3(3), IRF4(2), IRF5(2), IRF6(2), IRF7(1), JUN(2), LTA(2), MAP2K4(5), MAP3K1(8), MAPK10(3), MDM2(3), NFKB1(5), NFKBIB(4), PLEKHG5(5), PRF1(1), RELA(2), TNF(2), TNFRSF10B(2), TNFRSF1A(3), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(2), TNFSF10(2), TP73(5), TRAF1(2), TRAF2(2), TRAF3(2)	11006024	127	44	127	40	39	40	4	27	17	0	0.14	1.00	1.00
395	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(4), ALDH4A1(2), ALDH5A1(3), CAD(7), CPS1(15), EPRS(6), GAD1(3), GAD2(4), GCLM(2), GFPT1(3), GLS(4), GLS2(5), GLUD1(4), GLUL(2), GMPS(3), GOT1(2), GOT2(3), GPT(1), GPT2(3), GSS(1), NADSYN1(5), PPAT(1), QARS(5)	6578621	88	44	86	30	31	28	5	19	5	0	0.33	1.00	1.00
396	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(2), ABAT(4), ACADS(1), ACAT1(3), ACAT2(3), ACSM1(1), AKR1B10(1), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH5A1(3), ALDH9A1(4), BDH1(1), DDHD1(7), EHHADH(2), GAD1(3), GAD2(4), HADH(2), HADHA(2), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(2), HSD3B7(3), ILVBL(3), L2HGDH(1), OXCT1(4), PDHA1(1), PDHA2(4), PDHB(2), PRDX6(1), RDH11(1), RDH12(1)	8032647	91	44	88	34	30	24	1	27	9	0	0.42	1.00	1.00
397	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(9), ATP4B(2), ATP6AP1(4), ATP6V0A1(4), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), ATP7A(5), ATP7B(12), COX10(1), COX4I1(4), COX6B1(1), COX7A2(2), COX7C(1), NDUFA1(1), NDUFA10(1), NDUFA8(1), NDUFB2(1), NDUFB7(1), NDUFS1(5), NDUFS2(2), NDUFV1(1), PPA2(2), SDHA(5), SDHB(4), SHMT1(1), UQCRB(1), UQCRC1(2), UQCRFS1(1)	7537276	107	44	107	38	28	40	7	23	9	0	0.31	1.00	1.00
398	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(3), APC(20), AXIN1(7), BTRC(3), CTNNB1(11), DLL1(3), DVL1(4), FZD1(8), GSK3B(2), NOTCH1(15), PSEN1(1), WNT1(3)	4179091	80	44	78	35	27	16	2	18	15	2	0.78	1.00	1.00
399	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	CDK5(2), CDK5R1(1), CFL1(1), CHN1(4), LIMK1(4), MAP3K1(8), MYL2(1), MYLK(9), NCF2(1), PAK1(4), PDGFRA(4), PIK3R1(7), PLD1(7), PPP1R12B(7), RALBP1(7), RPS6KB1(3), TRIO(22), VAV1(7), WASF1(4)	6492704	103	44	102	46	35	32	2	20	13	1	0.83	1.00	1.00
400	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(2), AKT3(3), ARHGEF11(12), BCL2(1), CDC42(1), DLG4(5), LPA(11), MAP2K4(5), MAP3K1(8), MAP3K5(3), MAPK8(4), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PDK1(1), PHKA2(7), PI3(2), PIK3CB(6), PLD1(7), PLD2(11), PLD3(5), PTK2(7), RDX(2), ROCK1(7), ROCK2(3), SERPINA4(2), SRF(1), TBXA2R(7)	9724990	143	44	143	49	47	46	8	26	16	0	0.23	1.00	1.00
401	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CALM1(1), CALM2(2), CALM3(1), CD3E(3), CD3G(2), ELK1(2), FYN(5), GRB2(1), JUN(2), LCK(1), MAP2K1(4), MAP2K4(5), MAP3K1(8), MAPK3(1), MAPK8(4), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NFKB1(5), PIK3R1(7), PLCG1(10), PPP3CA(3), PPP3CB(1), PTPN7(2), RAF1(6), RELA(2), SHC1(3), SOS1(4), VAV1(7), ZAP70(4)	8597919	127	44	125	37	35	44	2	24	22	0	0.095	1.00	1.00
402	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(17), ATR(5), BRCA1(9), CCNB1(1), CDC25A(2), CDC25B(4), CDC25C(3), CDC34(1), CDKN1A(1), CDKN2D(1), CHEK1(2), CHEK2(5), EP300(15), MDM2(3), MYT1(12), PRKDC(22), RPS6KA1(6), WEE1(1), YWHAH(1), YWHAQ(2)	8257399	113	43	112	35	35	38	4	16	19	1	0.25	1.00	1.00
403	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(3), ALG10(5), ALG10B(2), ALG12(1), ALG13(2), ALG2(1), ALG3(2), ALG8(1), ALG9(2), B4GALT1(2), B4GALT2(5), B4GALT3(1), DOLPP1(2), DPM1(1), FUT8(3), GANAB(3), MAN1A2(1), MAN1B1(2), MAN1C1(3), MAN2A1(7), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(1), MGAT5(6), MGAT5B(3), RFT1(2), RPN1(1), RPN2(3), STT3B(5)	8408701	81	43	80	43	21	22	5	20	13	0	0.98	1.00	1.00
404	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(4), ARRB2(3), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CLCA1(3), CLCA2(6), CLCA4(6), CNGA3(6), CNGA4(9), CNGB1(7), GUCA1A(1), GUCA1C(1), PDC(1), PDE1C(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKG1(6), PRKG2(6), PRKX(2)	6056900	84	43	82	33	28	23	4	20	9	0	0.50	1.00	1.00
405	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(2), CALM1(1), CALM2(2), CALM3(1), CD79A(6), ELK1(2), GRB2(1), JUN(2), LYN(4), MAP2K1(4), MAP3K1(8), MAPK14(1), MAPK3(1), MAPK8(4), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), PLCG1(10), PPP3CA(3), PPP3CB(1), RAF1(6), SHC1(3), SOS1(4), SYK(3), VAV1(7)	7539272	109	42	107	33	37	38	2	20	12	0	0.093	1.00	1.00
406	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(2), CDC7(3), CDK2(2), CDT1(2), DIAPH2(3), MCM10(5), MCM2(9), MCM3(4), MCM4(6), MCM5(8), MCM6(1), MCM7(5), NACA(1), ORC1L(10), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(2), POLD1(7), POLD3(2), POLE(14), POLE2(2), PRIM1(1), RFC1(1), RFC2(1), RFC3(4), RFC4(1), RPA1(1), RPA2(1), RPA3(1), RPS27A(1), UBC(3)	10078556	117	42	116	50	39	29	6	22	21	0	0.82	1.00	1.00
407	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(11), CALM1(1), CALM2(2), CALM3(1), CREB1(4), ELK1(2), GNAI1(1), GNAQ(1), GNAS(14), GNB1(1), GNGT1(3), JUN(2), MAP2K1(4), MAPK3(1), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), PLCG1(10), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RAF1(6), RPS6KA3(1)	6873696	115	42	113	37	40	43	1	20	11	0	0.11	1.00	1.00
408	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	71	B2M(2), CALR(4), CANX(1), CD4(3), CD74(1), CD8A(2), CD8B(1), CIITA(6), CREB1(4), CTSL1(2), CTSS(1), HLA-C(4), HLA-DMA(2), HLA-DMB(3), HLA-DOA(1), HLA-DPA1(2), HLA-DPB1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(3), HLA-DRB1(1), HLA-E(3), HLA-F(5), HLA-G(2), HSP90AA1(2), HSP90AB1(2), HSPA5(1), IFI30(1), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), KIR2DL1(4), KIR2DL3(1), KIR2DL4(3), KIR2DS4(2), KIR3DL1(2), KLRC1(2), KLRC2(2), KLRD1(2), LGMN(4), LTA(2), PDIA3(1), PSME2(2), RFX5(3), RFXANK(3), TAP1(3), TAP2(7), TAPBP(3)	8916430	121	42	118	45	20	46	9	27	18	1	0.53	1.00	1.00
409	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(15), ACAT1(3), ACAT2(3), ACYP2(1), ADH5(1), AKR1B1(5), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), DLAT(6), DLD(2), GRHPR(2), HAGH(2), LDHB(2), LDHC(1), LDHD(2), MDH1(3), MDH2(1), ME1(3), ME2(4), ME3(5), PC(6), PCK1(4), PDHA1(1), PDHA2(4), PDHB(2), PKLR(4), PKM2(2)	7292657	116	42	116	34	34	35	5	28	14	0	0.079	1.00	1.00
410	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(3), CLOCK(2), CRY1(1), CRY2(2), DAZAP2(3), DNAJA1(2), EIF4G2(1), ETV6(3), G0S2(1), GFRA1(5), GSTM3(1), GSTP1(1), HERPUD1(1), HSPA8(5), KLF9(1), MYF6(2), NCKAP1(6), NR1D2(4), PER1(4), PER2(10), PPP1R3C(3), PPP2CB(3), PSMA4(3), PURA(1), SF3A3(2), SUMO3(1), TOB1(1), TUBB3(8), UCP3(2), UGP2(1), ZFR(7)	7197869	90	41	90	37	28	28	3	26	5	0	0.67	1.00	1.00
411	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(2), ATM(17), ATR(5), CCNA1(5), CCND1(1), CCNE1(3), CDC25A(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(4), GSK3B(2), HDAC1(2), RB1(8), SKP2(4), TFDP1(2), TGFB1(3), TGFB2(6), TGFB3(4)	5826462	77	41	75	33	19	25	2	20	10	1	0.82	1.00	1.00
412	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(4), AASDH(4), AASS(2), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), BBOX1(1), DLST(1), DOT1L(9), EHHADH(2), EHMT1(7), EHMT2(4), GCDH(3), HADHA(2), PLOD1(6), PLOD2(3), PLOD3(4), SDS(1), SHMT1(1), SHMT2(4), TMLHE(4)	7296757	100	41	99	42	25	36	3	20	16	0	0.55	1.00	1.00
413	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(11), CD3E(3), CD3G(2), CD4(3), CREBBP(13), CSK(3), GNAS(14), GNB1(1), GNGT1(3), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PTPRC(16), ZAP70(4)	4528093	93	40	90	40	24	30	2	20	17	0	0.81	1.00	1.00
414	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(4), CFL1(1), GNAQ(1), GNAS(14), GNB1(1), GNGT1(3), LIMK1(4), MAP2K1(4), MAPK1(2), MAPK3(1), MYL2(1), NOX1(4), PIK3C2G(3), PLCB1(12), PPP1R12B(7), PTK2(7), RAF1(6), ROCK2(3)	5019116	79	40	78	24	28	17	4	17	13	0	0.35	1.00	1.00
415	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(11), CD3E(3), CD3G(2), CD4(3), CREBBP(13), CSK(3), GNAS(14), GNB1(1), GNGT1(3), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PTPRC(16), ZAP70(4)	4528093	93	40	90	40	24	30	2	20	17	0	0.81	1.00	1.00
416	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(6), DIAPH1(4), FYN(5), GSN(5), ITGA1(4), ITGB1(4), MAP2K1(4), MAPK1(2), MAPK3(1), MYL2(1), MYLK(9), PIK3R1(7), PTK2(7), PXN(2), RAF1(6), ROCK1(7), SHC1(3), TLN1(13)	6969995	90	40	89	30	22	30	5	18	14	1	0.31	1.00	1.00
417	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(4), EGF(5), EGFR(10), ELK1(2), GRB2(1), JAK1(4), JUN(2), MAP2K1(4), MAP2K4(5), MAP3K1(8), MAPK3(1), MAPK8(4), PIK3R1(7), PLCG1(10), RAF1(6), SHC1(3), SOS1(4), SRF(1), STAT1(6), STAT3(7), STAT5A(1)	6591660	95	40	94	31	25	34	1	20	14	1	0.26	1.00	1.00
418	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(10), ELK1(2), GNAS(14), GNB1(1), GNGT1(3), GRB2(1), IGF1R(11), ITGB1(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MKNK1(1), NGFR(5), PDGFRA(4), PPP2CA(3), PTPRR(4), RAF1(6), RPS6KA1(6), SHC1(3), SOS1(4), STAT3(7)	6521941	97	40	95	40	30	33	1	22	11	0	0.69	1.00	1.00
419	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(4), ALDOC(3), DLAT(6), DLD(2), ENO1(3), ENO2(1), ENO3(3), FBP1(1), FBP2(3), GAPDH(1), GAPDHS(2), GCK(3), GOT1(2), GOT2(3), GPI(4), HK1(6), HK2(6), HK3(3), LDHAL6B(2), LDHB(2), LDHC(1), MDH1(3), MDH2(1), PC(6), PCK1(4), PDHA1(1), PDHA2(4), PDHB(2), PDHX(2), PFKL(7), PFKM(3), PFKP(8), PGAM2(2), PGK1(1), PGK2(1), PKLR(4), PKM2(2), TNFAIP1(3), TPI1(2)	8371115	117	40	117	48	50	35	4	22	6	0	0.48	1.00	1.00
420	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(3), AKR1D1(2), ARSD(1), ARSE(3), CARM1(2), CYP11B1(2), CYP11B2(2), CYP19A1(5), HSD11B1(1), HSD11B2(2), HSD17B1(3), HSD17B12(2), HSD17B2(1), HSD17B3(2), HSD17B7(1), HSD3B1(1), HSD3B2(1), LCMT1(1), LCMT2(7), METTL6(1), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), SRD5A1(2), SRD5A2(3), STS(4), SULT1E1(3), SULT2A1(1), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), WBSCR22(2)	9748406	96	40	96	38	25	36	3	18	14	0	0.47	1.00	1.00
421	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(4), ACAA1(1), ACAA2(1), ACADM(1), ACADS(1), ACAT1(3), ACAT2(3), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH6A1(1), ALDH9A1(4), AOX1(3), AUH(5), BCAT1(2), BCAT2(1), BCKDHA(4), DBT(2), DLD(2), EHHADH(2), HADH(2), HADHA(2), HADHB(2), HIBADH(2), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(2), IVD(1), MCCC1(3), MCCC2(2), MCEE(3), MUT(3), OXCT1(4), PCCA(7), PCCB(2)	8523895	98	40	94	34	23	30	1	23	20	1	0.44	1.00	1.00
422	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(9), EXT2(6), EXTL1(4), EXTL2(2), EXTL3(8), GLCE(2), HS2ST1(1), HS3ST1(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), HS3ST5(4), HS6ST1(2), HS6ST2(1), HS6ST3(4), NDST1(8), NDST2(5), NDST3(5), NDST4(10)	4080441	82	40	81	33	27	32	1	16	6	0	0.62	1.00	1.00
423	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ARHGAP4(2), ARHGAP5(6), ARHGAP6(3), ARHGEF1(2), ARHGEF11(12), ARHGEF5(5), ARPC1A(3), ARPC1B(1), ARPC4(1), BAIAP2(3), CFL1(1), DIAPH1(4), GSN(5), LIMK1(4), MYL2(1), MYLK(9), OPHN1(6), PIP5K1A(3), PPP1R12B(7), ROCK1(7), TLN1(13), VCL(2)	8988188	102	40	102	49	38	34	3	17	9	1	0.88	1.00	1.00
424	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	31	DUSP1(1), GORASP1(2), MAP2K4(5), MAP2K7(13), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3), MAPKAPK5(2), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PIK3CD(8), PIK3R1(7), TRAF2(2), TRAF3(2), TRAF6(4)	6158659	91	40	90	30	35	24	3	15	14	0	0.19	1.00	1.00
425	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(2), CAMK2G(4), DAG1(7), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), NFAT5(5), PDE6A(5), PDE6B(7), PDE6C(2), PDE6G(1), SLC6A13(1), TF(6)	7129506	99	40	99	40	32	31	8	13	14	1	0.49	1.00	1.00
426	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(16), MAP2(18), PPP1CA(2), PPP2CA(3), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAR2A(1), PRKAR2B(6), PRKCE(6)	3610025	59	39	58	23	11	22	0	20	6	0	0.74	1.00	1.00
427	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(2), AGTR1(1), CALM1(1), CALM2(2), CALM3(1), EGFR(10), ELK1(2), GNAQ(1), GRB2(1), JUN(2), MAP2K1(4), MAP2K2(1), MAP2K4(5), MAP3K1(8), MAPK1(2), MAPK3(1), MAPK8(4), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), PAK1(4), PTK2(7), PTK2B(8), RAF1(6), SHC1(3), SOS1(4)	6640676	92	39	92	33	27	27	6	19	13	0	0.35	1.00	1.00
428	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(2), AVP(3), CABIN1(8), CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), HDAC5(4), IGF1(2), IGF1R(11), INSR(10), MAP2K6(2), MAPK14(1), MAPK7(8), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), MYOD1(3), NFATC1(9), NFATC2(8), PIK3R1(7), PPP3CA(3), PPP3CB(1), YWHAH(1)	6411234	103	39	103	33	37	37	2	17	10	0	0.059	1.00	1.00
429	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(3), C1GALT1(1), C1GALT1C1(4), GALNT1(3), GALNT10(3), GALNT11(5), GALNT12(2), GALNT13(3), GALNT14(6), GALNT2(3), GALNT3(1), GALNT4(1), GALNT5(4), GALNT6(2), GALNT8(5), GALNT9(3), GALNTL1(2), GALNTL2(6), GALNTL4(5), GALNTL5(4), GCNT1(1), GCNT3(2), GCNT4(2), OGT(2), ST3GAL1(3), ST3GAL2(4), ST6GALNAC1(2)	6154073	82	39	81	34	31	25	2	20	4	0	0.73	1.00	1.00
430	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(1), ARSE(3), ASAH1(2), B4GALT6(2), CERK(3), DEGS1(1), DEGS2(2), ENPP7(4), GAL3ST1(4), GALC(5), GBA(4), GLB1(3), LCT(11), NEU1(1), NEU2(2), NEU3(2), NEU4(2), PPAP2C(5), SGMS1(2), SMPD1(4), SMPD3(5), SMPD4(3), SPHK1(5), SPTLC2(3), UGT8(4)	7037637	84	39	84	42	39	30	1	10	4	0	0.76	1.00	1.00
431	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ACTG2(6), ADCY3(3), ADCY9(6), ARF1(2), ARL4D(1), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), ERO1L(1), GNAS(14), PLCG1(10), PLCG2(6), SEC61A1(1), SEC61A2(1), SEC61B(1), SEC61G(1), TRIM23(2)	7323692	89	39	87	35	33	24	3	23	6	0	0.58	1.00	1.00
432	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(3), CAPN2(4), CAPNS1(1), CAPNS2(1), EGF(5), EGFR(10), ITGA1(4), ITGB1(4), MAPK1(2), MAPK3(1), MYL2(1), MYLK(9), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PTK2(7), PXN(2), TLN1(13)	6464962	83	39	81	41	30	23	4	16	10	0	0.80	1.00	1.00
433	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(2), BAK1(2), BCL2(1), BID(1), BIRC2(2), BIRC3(4), CASP2(3), CASP3(1), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), FAS(3), JUN(2), MAP2K4(5), MAP3K1(8), MAP3K14(3), MAPK10(3), MDM2(3), NFKB1(5), PARP1(4), PRF1(1), RELA(2), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TNFSF10(2), TRAF1(2), TRAF2(2)	7226939	78	38	78	28	23	22	2	20	11	0	0.42	1.00	1.00
434	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(2), BCL2(1), BID(1), BIRC2(2), BIRC3(4), CASP10(3), CASP3(1), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), DFFA(2), DFFB(2), GAS2(1), LMNA(5), MAP3K14(3), NFKB1(5), RELA(2), SPTAN1(13), TNFRSF10A(2), TNFRSF10B(2), TNFRSF25(2), TNFSF10(2), TRAF2(2)	6601643	68	38	68	20	17	18	2	21	10	0	0.38	1.00	1.00
435	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(11), AKT1(2), ASAH1(2), GNAI1(1), GNB1(1), GNGT1(3), ITGAV(4), ITGB3(5), MAPK1(2), MAPK3(1), PDGFA(1), PDGFRA(4), PIK3R1(7), PLCB1(12), PTK2(7), SMPD1(4), SPHK1(5)	4990934	72	38	72	34	23	26	5	7	11	0	0.76	1.00	1.00
436	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(3), ARSB(3), FUCA1(1), FUCA2(2), GALNS(2), GBA(4), GLB1(3), GNS(3), GUSB(3), HEXA(1), HEXB(3), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(2), HYAL2(4), IDS(3), IDUA(1), LCT(11), MAN2B1(8), MAN2B2(9), MAN2C1(4), MANBA(2), NAGLU(2), NEU1(1), NEU2(2), NEU3(2), NEU4(2), SPAM1(5)	6795121	93	38	92	38	35	33	2	15	8	0	0.54	1.00	1.00
437	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(14), ANAPC11(1), ANAPC2(3), ANAPC4(2), ANAPC5(2), ANAPC7(1), BTRC(3), CDC16(1), CDC20(2), CDC23(4), CDC26(1), CDC27(2), CUL1(10), CUL2(4), CUL3(4), FBXW11(5), FBXW7(11), FZR1(3), ITCH(3), SKP2(4), SMURF1(1), SMURF2(1), TCEB1(1), UBA1(1), UBE2D3(1), UBE2E3(3), WWP1(8), WWP2(10)	7995810	106	38	96	32	30	39	1	21	15	0	0.20	1.00	1.00
438	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CDC42(1), CREB1(4), DAXX(3), DDIT3(3), ELK1(2), GRB2(1), HSPB1(1), HSPB2(1), MAP2K4(5), MAP2K6(2), MAP3K1(8), MAP3K5(3), MAP3K7(7), MAP3K9(5), MAPK14(1), MAPKAPK5(2), MAX(1), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), MKNK1(1), PLA2G4A(3), SHC1(3), STAT1(6), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TRAF2(2)	7265538	92	38	92	31	31	32	3	14	12	0	0.23	1.00	1.00
439	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(4), ELK1(2), GRB2(1), JAK1(4), JUN(2), MAP2K1(4), MAP2K4(5), MAP3K1(8), MAPK3(1), MAPK8(4), PDGFA(1), PDGFRA(4), PIK3R1(7), PLCG1(10), RAF1(6), SHC1(3), SOS1(4), SRF(1), STAT1(6), STAT3(7), STAT5A(1)	6079885	85	38	84	28	24	33	1	15	11	1	0.25	1.00	1.00
440	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), CDC42(1), CREB1(4), CREB3(3), CREB5(2), DUSP1(1), DUSP10(3), EEF2K(8), EIF4E(1), ELK1(2), HSPB1(1), IL1R1(3), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP3K10(6), MAP3K4(10), MAP3K5(3), MAP3K7(7), MAPK1(2), MAPK11(1), MAPK13(1), MAPK14(1), MAPKAPK5(2), MKNK1(1), MYEF2(4), NFKB1(5), NR2C2(3), SRF(1), TRAF6(4)	6586325	90	38	89	35	28	31	5	14	12	0	0.50	1.00	1.00
441	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), ABAT(4), ADSL(4), ADSS(3), AGXT(1), AGXT2(6), ASL(5), ASNS(4), CAD(7), CRAT(3), DARS(2), DDO(2), GAD1(3), GAD2(4), GOT1(2), GOT2(3), GPT(1), GPT2(3), NARS(3), PC(6)	5146752	68	37	66	28	31	18	1	15	3	0	0.58	1.00	1.00
442	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(17), ATR(5), BRCA1(9), BRCA2(17), CHEK1(2), CHEK2(5), FANCA(6), FANCC(2), FANCD2(8), FANCE(1), FANCF(1), FANCG(3), HUS1(1), MRE11A(2), RAD1(1), RAD50(6), RAD51(1), RAD9A(1)	8614325	88	37	87	23	19	37	3	17	11	1	0.12	1.00	1.00
443	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(3), ACTN2(15), ACTN3(2), BCAR1(4), CSK(3), CTNNA1(5), CTNNA2(13), CTNNB1(11), PTK2(7), PXN(2), VCL(2)	3758606	67	37	66	29	19	21	4	15	8	0	0.71	1.00	1.00
444	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	B2M(2), ITGB1(4), KLRC1(2), KLRC2(2), KLRD1(2), MAP2K1(4), MAPK3(1), PAK1(4), PIK3R1(7), PTK2B(8), PTPN6(3), SYK(3), VAV1(7)	3106561	49	37	48	17	9	18	1	11	10	0	0.55	1.00	1.00
445	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BAD(1), BRAF(5), CREB1(4), CREB3(3), CREB5(2), DUSP4(1), DUSP6(1), DUSP9(2), EEF2K(8), EIF4E(1), GRB2(1), MAP2K1(4), MAP2K2(1), MAP3K8(1), MAPK1(2), MAPK3(1), MKNK1(1), MOS(3), NFKB1(5), RAP1A(2), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), SHC1(3), SOS1(4), SOS2(5), TRAF3(2)	5838942	77	37	76	31	24	24	1	18	10	0	0.67	1.00	1.00
446	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	24	AKT1(2), AKT2(2), AKT3(3), CISH(2), GRB2(1), IARS(7), IL13RA1(2), IL4R(1), INPP5D(1), JAK1(4), JAK2(8), JAK3(3), NR0B2(2), PI3(2), PPP1R13B(6), RPS6KB1(3), SERPINA4(2), SHC1(3), SOS1(4), SOS2(5), TYK2(6)	6728953	69	37	69	29	14	25	1	18	10	1	0.78	1.00	1.00
447	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	24	EIF2B1(3), EIF2B3(3), EIF2B4(6), EIF2B5(4), EIF2S1(1), EIF2S2(2), EIF2S3(1), ELAVL1(3), FLT1(6), FLT4(8), HIF1A(2), KDR(7), NOS3(3), PIK3R1(7), PLCG1(10), PTK2(7), PXN(2), SHC1(3)	6270377	78	37	76	27	27	25	4	14	8	0	0.28	1.00	1.00
448	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	AKT1(2), EIF4A1(2), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4G1(10), EIF4G2(1), EIF4G3(5), GHR(5), IRS1(7), MAPK1(2), MAPK14(1), MAPK3(1), MKNK1(1), PABPC1(3), PDPK1(1), PIK3R1(7), PTEN(8), RPS6KB1(3)	5136188	64	36	64	29	14	24	3	13	10	0	0.88	1.00	1.00
449	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(9), CLYBL(1), DLD(2), DLST(1), FH(2), IDH1(1), IDH2(1), IDH3A(1), IDH3B(3), IDH3G(2), MDH1(3), MDH2(1), OGDH(8), OGDHL(3), PC(6), PCK1(4), PCK2(6), SDHA(5), SDHB(4), SDHC(1), SUCLA2(3), SUCLG1(2), SUCLG2(4)	5898386	75	36	73	27	29	20	4	14	8	0	0.36	1.00	1.00
450	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(1), B3GNT7(4), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), CHST1(11), CHST2(8), CHST6(5), FUT8(3), ST3GAL1(3), ST3GAL2(4), ST3GAL3(2), ST3GAL4(3)	2455818	56	36	55	26	29	12	1	12	2	0	0.76	1.00	1.00
451	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(4), ACACA(15), ACACB(13), ACADM(1), ACAT1(3), ACAT2(3), ACSS1(7), ACSS2(3), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH6A1(1), ALDH9A1(4), EHHADH(2), HADHA(2), LDHAL6B(2), LDHB(2), LDHC(1), MCEE(3), MLYCD(3), MUT(3), PCCA(7), PCCB(2), SUCLA2(3), SUCLG1(2), SUCLG2(4)	7842939	110	36	106	34	30	29	2	26	23	0	0.22	1.00	1.00
452	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(4), ALAS1(2), ALAS2(4), BLVRA(2), COX10(1), COX15(3), CP(5), CPOX(1), EARS2(2), EPRS(6), FECH(5), FTH1(1), FTMT(2), GUSB(3), HCCS(1), HMOX1(3), MMAB(1), PPOX(2), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), UROD(1), UROS(3)	8152186	76	36	76	43	15	28	3	22	8	0	0.99	1.00	1.00
453	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLAT(6), DLD(2), DLST(1), FH(2), IDH2(1), IDH3A(1), IDH3B(3), IDH3G(2), MDH1(3), MDH2(1), OGDH(8), PC(6), PDHA1(1), PDHA2(4), PDHB(2), PDHX(2), PDK1(1), PDK3(2), PDP2(2), SDHA(5), SDHB(4), SDHC(1), SUCLA2(3), SUCLG1(2), SUCLG2(4)	5599047	69	36	68	33	22	17	3	19	8	0	0.90	1.00	1.00
454	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CD14(1), ELK1(2), IKBKB(3), IRAK1(5), JUN(2), LY96(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP3K1(8), MAP3K14(3), MAP3K7(7), MAPK14(1), MAPK8(4), MYD88(2), NFKB1(5), PPARA(3), RELA(2), TIRAP(2), TLR10(3), TLR2(3), TLR3(2), TLR6(3), TLR7(3), TLR9(10), TOLLIP(1), TRAF6(4)	6877433	88	36	87	33	29	22	5	20	12	0	0.48	1.00	1.00
455	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACAA2(1), ACADL(2), ACADM(1), ACADS(1), ACADSB(3), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH6A1(1), ALDH9A1(4), AOX1(3), BCAT1(2), BCKDHA(4), EHHADH(2), HADHA(2), HADHB(2), HIBADH(2), HMGCL(1), IVD(1), MCCC1(3), MCCC2(2), MCEE(3), MUT(3), OXCT1(4), PCCA(7), PCCB(2), SDS(1)	7124179	92	36	89	35	17	34	0	22	18	1	0.62	1.00	1.00
456	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(2), ATM(17), BRCA1(9), CDKN1A(1), CHEK1(2), CHEK2(5), JUN(2), MAPK8(4), MDM2(3), MRE11A(2), NFKB1(5), RAD50(6), RAD51(1), RBBP8(4), RELA(2), TP73(5)	5750030	70	35	69	19	15	23	3	16	12	1	0.27	1.00	1.00
457	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ABAT(4), ACADS(1), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH5A1(3), ALDH9A1(4), EHHADH(2), GAD1(3), GAD2(4), HADHA(2), HMGCL(1), L2HGDH(1), OXCT1(4), PDHA1(1), PDHA2(4), PDHB(2), SDHB(4), SDS(1)	5090684	77	35	75	30	23	22	1	22	9	0	0.50	1.00	1.00
458	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(5), AKR1B10(1), B4GALT1(2), B4GALT2(5), GAA(2), GALE(1), GALK1(2), GALK2(2), GALT(1), GANC(4), GCK(3), GLB1(3), HK1(6), HK2(6), HK3(3), HSD3B7(3), LALBA(1), LCT(11), MGAM(7), PFKL(7), PFKM(3), PFKP(8), PGM1(3), PGM3(6), RDH11(1), RDH12(1), UGP2(1)	7644031	98	35	97	43	46	33	4	9	6	0	0.54	1.00	1.00
459	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(4), POLA2(2), POLD1(7), POLD3(2), POLE(14), POLE2(2), POLE3(1), POLE4(1), POLG(4), POLG2(3), POLH(2), POLK(3), POLL(1), POLM(3), POLQ(14), PRIM1(1), PRIM2(3), REV1(5), REV3L(17)	8111175	89	35	89	43	22	29	2	18	18	0	0.95	1.00	1.00
460	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(11), CAP1(2), CCNB1(1), CDC25C(3), GNAI1(1), GNAS(14), GNB1(1), GNGT1(3), MAPK1(2), MAPK3(1), MYT1(12), PIN1(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RPS6KA1(6)	4049240	74	35	73	34	28	24	1	14	7	0	0.76	1.00	1.00
461	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(11), ARHGEF1(2), F2(4), F2R(2), GNA12(1), GNAI1(1), GNAQ(1), GNB1(1), GNGT1(3), MAP3K7(7), PIK3R1(7), PLCB1(12), PPP1R12B(7), PTK2B(8), ROCK1(7)	4670333	74	35	74	34	23	25	1	14	11	0	0.87	1.00	1.00
462	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(4), CALM1(1), CALM2(2), CALM3(1), GNAQ(1), GRB2(1), JUN(2), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP3K1(8), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(4), PAK1(4), PLCG1(10), PTK2B(8), RAF1(6), SHC1(3), SOS1(4)	5608885	74	35	73	27	23	23	1	17	10	0	0.51	1.00	1.00
463	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(5), DYRK1B(6), GLI2(9), GLI3(16), GSK3B(2), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), SMO(6), SUFU(3)	3254678	62	35	62	31	18	17	2	17	8	0	0.81	1.00	1.00
464	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(2), AKT2(2), AKT3(3), BAD(1), BCL2(1), GRB2(1), GSK3A(1), GSK3B(2), IL4R(1), IRS1(7), IRS2(3), JAK1(4), JAK3(3), MAP4K1(2), MAPK1(2), MAPK3(1), PDK1(1), PIK3CD(8), PIK3R1(7), PPP1R13B(6), RAF1(6), SHC1(3), SOCS1(1), SOS1(4), SOS2(5)	6764281	77	35	75	28	25	28	0	15	8	1	0.43	1.00	1.00
465	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), CARS(4), DARS(2), EPRS(6), FARS2(7), GARS(1), HARS(4), IARS(7), KARS(3), LARS(3), LARS2(5), MARS(3), MARS2(1), NARS(3), QARS(5), RARS(2), SARS(4), TARS(6), WARS(3), WARS2(5), YARS(1)	6357797	77	34	76	24	23	30	2	18	4	0	0.24	1.00	1.00
466	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(11), AKT1(2), CAMK2A(1), CAMK2B(2), CAMK2G(4), CREB1(4), GNAS(14), GRB2(1), MAPK1(2), MAPK14(1), MAPK3(1), PIK3R1(7), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RPS6KA1(6), SOS1(4)	5304031	75	34	74	28	24	30	0	10	11	0	0.53	1.00	1.00
467	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(1), ATG7(4), BECN1(1), GABARAPL1(3), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), IFNG(2), PIK3C3(8), PIK3R4(8), PRKAA1(1), PRKAA2(3), ULK1(11), ULK2(4), ULK3(2)	4186451	62	34	62	21	14	18	6	15	9	0	0.38	1.00	1.00
468	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	AKT1(2), EIF4A1(2), EIF4A2(3), EIF4B(2), EIF4E(1), EIF4EBP1(1), EIF4G1(10), EIF4G2(1), EIF4G3(5), MKNK1(1), PDPK1(1), PIK3R1(7), PPP2CA(3), PTEN(8), RPS6(1), RPS6KB1(3), TSC1(4), TSC2(4)	5046532	59	34	59	32	16	22	1	11	9	0	0.98	1.00	1.00
469	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(4), F2R(2), GNAI1(1), GNB1(1), GNGT1(3), ITGA1(4), ITGB1(4), MAP2K1(4), MAPK1(2), MAPK3(1), PLA2G4A(3), PLCB1(12), PTGS1(5), PTK2(7), RAF1(6), SYK(3), TBXAS1(2)	4809425	64	34	63	27	17	20	5	13	9	0	0.70	1.00	1.00
470	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM2(2), CALM3(1), EGR2(3), EGR3(1), GNAQ(1), MAP3K1(8), NFATC1(9), NFATC2(8), NFKB1(5), PLCG1(10), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RELA(2), VIP(1), VIPR2(4)	5516699	75	34	74	32	27	26	1	15	6	0	0.58	1.00	1.00
471	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(11), AKT1(2), BAD(1), BCL2(1), CSF2RB(7), IGF1(2), IGF1R(11), IL3(1), IL3RA(4), KIT(6), KITLG(3), PIK3R1(7), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), YWHAH(1)	3899085	72	33	72	31	20	34	0	12	6	0	0.50	1.00	1.00
472	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP2(3), ACP5(2), ACPP(3), ACPT(1), ALPI(4), ALPL(3), ALPP(5), ALPPL2(4), CYP19A1(5), CYP1A1(3), CYP1A2(3), CYP2A13(4), CYP2A6(2), CYP2A7(3), CYP2B6(2), CYP2C18(5), CYP2C19(6), CYP2C9(1), CYP2D6(3), CYP2E1(5), CYP2F1(1), CYP2J2(2), CYP3A4(1), CYP3A5(1), CYP3A7(2), CYP4B1(1), CYP4F8(2), CYP51A1(3), PON1(1)	5772592	81	33	80	25	35	23	3	14	6	0	0.11	1.00	1.00
473	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(5), AKR1B10(1), ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), FPGT(3), FUK(1), GMDS(2), GMPPA(4), HK1(6), HK2(6), HK3(3), HSD3B7(3), LHPP(3), MTMR1(3), MTMR2(3), MTMR6(4), PFKFB2(5), PFKFB3(2), PFKFB4(1), PFKL(7), PFKM(3), PFKP(8), PGM2(2), PHPT1(3), PMM1(1), PMM2(1), RDH11(1), RDH12(1), TPI1(2), TSTA3(4)	7358127	99	33	99	32	43	35	3	14	4	0	0.070	1.00	1.00
474	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	BCL2(1), CREBBP(13), EP300(15), FYN(5), IL7R(3), JAK1(4), JAK3(3), LCK(1), NMI(1), PIK3R1(7), PTK2B(8), STAT5A(1), STAT5B(4)	4958017	66	33	66	26	14	21	1	13	16	1	0.70	1.00	1.00
475	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), ERCC3(3), GTF2B(1), GTF2E1(5), GTF2E2(2), GTF2F2(2), GTF2H1(1), ILK(2), MNAT1(2), POLR1A(8), POLR1B(2), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3B(6), POLR3D(1), POLR3E(1), POLR3K(1), TAF13(1), TAF5(2), TAF6(7), TAF7(4), TBP(3)	6943057	73	33	73	28	24	22	2	17	8	0	0.56	1.00	1.00
476	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(4), CRK(1), CXCR4(2), GNAI1(1), GNAQ(1), GNB1(1), GNGT1(3), MAP2K1(4), MAPK1(2), MAPK3(1), NFKB1(5), PIK3C2G(3), PIK3R1(7), PLCG1(10), PTK2(7), PTK2B(8), PXN(2), RAF1(6), RELA(2)	5056309	70	32	69	24	18	20	4	14	14	0	0.42	1.00	1.00
477	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(7), DDX20(3), ETS1(4), ETS2(1), HDAC2(4), HDAC5(4), JUN(2), NCOR2(15), RBL1(5), RBL2(1), SIN3A(5), SIN3B(8)	5094510	59	32	59	28	19	13	1	22	4	0	0.87	1.00	1.00
478	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2(4), F2R(2), F3(1), F5(9), F7(6), FGA(5), FGB(3), FGG(2), PROC(3), PROS1(6), SERPINC1(2), TFPI(3)	3250220	49	32	48	18	14	11	2	18	4	0	0.61	1.00	1.00
479	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CARM1(2), CBS(3), CTH(2), GGT1(8), LCMT1(1), LCMT2(7), MARS(3), MARS2(1), MAT1A(3), MAT2B(1), METTL6(1), PAPSS1(4), PAPSS2(2), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), SCLY(1), SEPHS1(1), SEPHS2(1), WBSCR22(2)	4921872	57	32	56	23	17	19	2	10	9	0	0.50	1.00	1.00
480	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(4), ACE2(5), AGT(2), AGTR1(1), AGTR2(1), ANPEP(3), CPA3(1), CTSG(3), ENPEP(8), LNPEP(9), MAS1(2), MME(5), NLN(7), REN(3), THOP1(5)	4178900	59	32	59	22	18	25	2	13	1	0	0.35	1.00	1.00
481	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(2), EGF(5), EGFR(10), GRB2(1), MAP2K1(4), MAPK1(2), MAPK3(1), PTPRB(12), RAF1(6), SHC1(3), SOS1(4), SPRY1(2), SPRY2(1), SPRY3(4), SPRY4(3)	4559878	60	32	60	23	13	16	1	20	10	0	0.71	1.00	1.00
482	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(2), BCL2(1), EGFR(10), IGF1R(11), POLR2A(9), PPP2CA(3), RB1(8), TEP1(14), TERF1(1), TERT(3), TNKS(6), XRCC5(3)	5417899	71	32	70	39	20	29	2	13	7	0	0.91	1.00	1.00
483	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(5), B4GALT1(2), B4GALT2(5), FBP2(3), GAA(2), GALE(1), GALK1(2), GALK2(2), GALT(1), GANAB(3), GCK(3), GLB1(3), HK1(6), HK2(6), HK3(3), LALBA(1), LCT(11), MGAM(7), PFKM(3), PFKP(8), PGM1(3), PGM3(6)	6455422	86	31	85	39	41	25	4	8	8	0	0.68	1.00	1.00
484	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(1), ALOX15(2), ALOX5(6), CYP1A2(3), CYP2C18(5), CYP2C19(6), CYP2C9(1), CYP2E1(5), CYP2J2(2), CYP3A4(1), CYP3A43(3), CYP3A5(1), CYP3A7(2), HSD3B7(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), RDH11(1), RDH12(1)	4734081	64	31	64	21	22	19	2	16	5	0	0.25	1.00	1.00
485	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(3), B4GALNT1(2), GLB1(3), HEXA(1), HEXB(3), LCT(11), SLC33A1(4), ST3GAL1(3), ST3GAL2(4), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC4(2), ST6GALNAC5(1), ST6GALNAC6(3), ST8SIA1(4), ST8SIA5(2)	3248951	50	31	50	24	21	14	1	12	2	0	0.76	1.00	1.00
486	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(13), DAXX(3), PAX3(4), PML(4), RARA(2), RB1(8), SIRT1(3), SP100(7), TNF(2), TNFRSF1A(3), TNFRSF1B(1)	3570196	50	31	49	20	17	13	2	10	8	0	0.61	1.00	1.00
487	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(11), GNAS(14), GNB1(1), GNGT1(3), PPP2CA(3), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAB2(1), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6)	3024169	57	30	56	22	22	19	1	8	7	0	0.59	1.00	1.00
488	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(5), EGFR(10), MAP2K1(4), MAP3K1(8), MAPK14(1), NCOR2(15), RARA(2), RXRA(3), THRA(4), THRB(5)	3390609	57	30	57	24	22	12	1	15	7	0	0.59	1.00	1.00
489	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(3), ARSD(1), ARSE(3), ASAH1(2), GAL3ST1(4), GALC(5), GBA(4), GLB1(3), LCT(11), NEU1(1), NEU2(2), NEU3(2), NEU4(2), PPAP2C(5), SMPD1(4), SPTLC2(3)	4767684	56	30	56	34	27	22	0	4	3	0	0.94	1.00	1.00
490	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(2), BAD(1), BCL2(1), CBL(2), GRB2(1), IL2RA(1), IRS1(7), JAK1(4), JAK3(3), MAPK1(2), MAPK3(1), NMI(1), PIK3R1(7), PTPN6(3), RAF1(6), RPS6KB1(3), SHC1(3), SOCS1(1), SOCS3(3), SOS1(4), STAT5A(1), STAT5B(4), SYK(3)	6563136	64	30	64	33	15	25	0	13	10	1	0.94	1.00	1.00
491	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(4), ELK1(2), GRB2(1), IL6(1), IL6ST(2), JAK1(4), JAK2(8), JAK3(3), JUN(2), MAP2K1(4), MAPK3(1), PTPN11(4), RAF1(6), SHC1(3), SOS1(4), SRF(1), STAT3(7)	4716154	57	30	57	23	10	24	1	16	5	1	0.66	1.00	1.00
492	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(1), AP2M1(7), ARF1(2), BAD(1), BTK(2), EEA1(3), GRASP(1), GSK3A(1), GSK3B(2), LYN(4), PDPK1(1), PFKL(7), PFKM(3), PFKP(8), PLCG1(10), PRKCE(6), RAB5A(2), RPS6KB1(3), VAV2(8)	4945101	74	30	73	27	28	25	3	14	4	0	0.31	1.00	1.00
493	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	AKT1(2), AKT2(2), AKT3(3), BPNT1(2), GRB2(1), ILK(2), MAPK1(2), MAPK3(1), PDK1(1), PIK3CD(8), PTEN(8), PTK2B(8), RBL2(1), SHC1(3), SOS1(4)	3606955	48	30	47	20	18	16	0	7	7	0	0.75	1.00	1.00
494	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(5), CCNB1(1), CCND1(1), CCND2(1), CCND3(2), CCNE1(3), CCNH(2), CDC25A(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(4), CDKN2D(1), RB1(8), RBL1(5), TFDP1(2)	3170298	44	29	43	22	11	13	1	15	4	0	0.86	1.00	1.00
495	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(2), BHMT(5), CBS(3), CTH(2), DNMT1(12), DNMT3A(7), DNMT3B(7), MARS(3), MARS2(1), MAT1A(3), MAT2B(1), MTR(9), SRM(1), TAT(1)	4087206	57	29	57	34	21	19	2	12	3	0	0.96	1.00	1.00
496	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(8), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(6), POLR3G(1), POLR3K(1)	4660849	49	29	49	18	14	18	1	13	3	0	0.49	1.00	1.00
497	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(5), ICAM1(2), ITGA4(8), ITGAL(7), ITGAM(5), ITGB1(4), ITGB2(6), SELE(3), SELL(4), SELP(2)	3170318	46	29	45	24	16	8	2	13	7	0	0.90	1.00	1.00
498	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(6), ARHGEF1(2), GNA12(1), GNAQ(1), GNB1(1), GNGT1(3), MYL2(1), MYLK(9), PLCB1(12), PPP1R12B(7), ROCK1(7)	4092582	50	29	50	24	16	13	0	12	8	1	0.91	1.00	1.00
499	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	26	ANXA1(3), ANXA2(1), ANXA4(2), ANXA5(1), ANXA6(2), CYP11A1(2), EDN1(3), EDNRA(3), HSD11B1(1), HSD11B2(2), PLA2G4A(3), PRL(2), PTGDR(5), PTGER2(2), PTGER4(1), PTGFR(3), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(2)	3913856	50	29	50	23	10	18	4	12	6	0	0.82	1.00	1.00
500	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(4), ATP6V0A1(4), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), SHMT1(1)	2985174	42	28	42	18	7	19	3	11	2	0	0.68	1.00	1.00
501	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(7), EPHB1(14), FYN(5), ITGA1(4), ITGB1(4), L1CAM(3), LYN(4), RAP1B(4), SELP(2)	3129109	48	28	47	26	17	11	4	13	3	0	0.90	1.00	1.00
502	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(4), ATP6V0A1(4), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), SHMT1(1)	2985174	42	28	42	18	7	19	3	11	2	0	0.68	1.00	1.00
503	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(3), FUCA1(1), FUCA2(2), GLB1(3), HEXA(1), HEXB(3), LCT(11), MAN2B1(8), MAN2B2(9), MAN2C1(4), MANBA(2), NEU1(1), NEU2(2), NEU3(2), NEU4(2)	4008904	54	28	54	24	25	14	0	8	7	0	0.71	1.00	1.00
504	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(3), GALNS(2), GLB1(3), GNS(3), GUSB(3), HEXA(1), HEXB(3), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(2), HYAL2(4), IDS(3), IDUA(1), LCT(11), NAGLU(2), SPAM1(5)	4045038	53	28	52	23	17	22	2	10	2	0	0.64	1.00	1.00
505	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT5(3), DPM1(1), FUT8(3), MAN1B1(2), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(1), MGAT5(6), RPN1(1), RPN2(3)	3928604	41	28	40	28	13	10	1	13	4	0	1.00	1.00	1.00
506	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(2), CCR2(3), CCR3(4), CCR5(1), CD4(3), CXCR4(2), IFNG(2), IFNGR1(2), IFNGR2(1), IL12B(2), IL12RB1(4), IL12RB2(5), IL18R1(2), IL2(1), IL4R(1), TGFB1(3), TGFB2(6), TGFB3(4)	3952435	48	28	48	21	10	16	2	14	6	0	0.73	1.00	1.00
507	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2G(4), CAMK4(4), HDAC5(4), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), PPARA(3), PPP3CA(3), PPP3CB(1), SLC2A4(1), YWHAH(1)	3996049	44	28	44	16	15	12	2	11	4	0	0.43	1.00	1.00
508	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(4), ATP6V0A1(4), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), FDXR(2), SHMT1(1)	3173221	44	28	44	19	8	19	3	11	3	0	0.68	1.00	1.00
509	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(11), ADRB2(4), GNAS(14), PLCE1(9), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6)	2913100	53	28	52	22	17	21	0	10	5	0	0.63	1.00	1.00
510	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(2), CCND1(1), CCNE1(3), CDK2(2), CDK6(4), CDKN1A(1), MAPK1(2), MAPK3(1), NFKB1(5), PAK1(4), PIK3R1(7), RAF1(6), RB1(8), RELA(2), TFDP1(2)	3575822	50	28	49	22	8	19	1	12	10	0	0.84	1.00	1.00
511	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(13), EP300(15), HDAC3(4), IKBKB(3), NFKB1(5), RELA(2), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF6(4)	4411752	52	28	52	19	14	15	2	9	12	0	0.53	1.00	1.00
512	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(6), APOA1(2), APOA4(1), APOC1(1), APOC2(2), CETP(2), CYP7A1(3), HMGCR(5), LCAT(1), LDLR(4), LIPC(2), LPL(2), LRP1(23), SCARB1(3), SOAT1(5)	5414420	62	28	62	33	23	18	4	12	5	0	0.90	1.00	1.00
513	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(4), ATP6V0A1(4), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), SHMT1(1)	2985174	42	28	42	18	7	19	3	11	2	0	0.68	1.00	1.00
514	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(3), AKR1D1(2), ARSB(3), ARSD(1), ARSE(3), CYP11B1(2), CYP11B2(2), HSD11B1(1), HSD11B2(2), HSD17B2(1), HSD17B3(2), HSD3B1(1), HSD3B2(1), SRD5A1(2), SRD5A2(3), STS(4), SULT1E1(3), SULT2A1(1), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2B15(1), UGT2B4(2)	5416915	45	27	45	20	14	19	0	5	7	0	0.63	1.00	1.00
515	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(3), IL13(2), MAF(2), MAP2K3(1), MAPK14(1), NFATC1(9), NFATC2(8), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6)	2362721	41	27	41	21	13	18	0	8	2	0	0.61	1.00	1.00
516	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(3), G6PD(2), GCLM(2), GGT1(8), GPX1(1), GPX3(1), GPX4(3), GSS(1), GSTA1(2), GSTA2(1), GSTA4(1), GSTM1(1), GSTM3(1), GSTM4(1), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(3), IDH1(1), IDH2(1), MGST1(2), MGST2(1), MGST3(1), PGD(1)	3558156	43	27	42	16	16	14	1	11	1	0	0.40	1.00	1.00
517	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), G6PD(2), GPI(4), H6PD(3), PFKL(7), PFKM(3), PFKP(8), PGD(1), PGLS(2), PGM1(3), PGM3(6), PRPS1(1), PRPS1L1(2), PRPS2(3), TALDO1(2), TKTL1(4), TKTL2(5)	4796632	67	27	67	28	22	25	3	14	3	0	0.48	1.00	1.00
518	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22RA1(1), IL22RA2(1), JAK1(4), JAK2(8), JAK3(3), SOCS3(3), STAT1(6), STAT3(7), STAT5A(1), STAT5B(4), TYK2(6)	3623192	46	27	46	19	11	17	1	10	6	1	0.68	1.00	1.00
519	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(5), CBS(3), CTH(2), DNMT1(12), DNMT3A(7), DNMT3B(7), MARS(3), MARS2(1), MAT1A(3), MAT2B(1), MTR(9)	3430793	53	27	53	30	21	16	2	11	3	0	0.92	1.00	1.00
520	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(4), BLVRA(2), CP(5), CPOX(1), EPRS(6), FECH(5), GUSB(3), HCCS(1), HMOX1(3), PPOX(2), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2B15(1), UGT2B4(2), UROD(1), UROS(3)	5424189	44	27	44	24	7	18	1	12	6	0	0.95	1.00	1.00
521	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), GOT1(2), GOT2(3), GPT(1), GPT2(3), MDH1(3), MDH2(1), ME1(3), ME2(4), ME3(5), PGK1(1), PKLR(4), PKM2(2), TPI1(2)	3558642	45	26	44	18	17	11	3	11	3	0	0.59	1.00	1.00
522	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD3E(3), CD3G(2), CD80(1), CD86(2), CTLA4(3), GRB2(1), HLA-DRA(3), HLA-DRB1(1), ICOS(1), IL2(1), ITK(4), LCK(1), PIK3R1(7), PTPN11(4)	2103600	34	26	33	14	6	13	2	7	6	0	0.76	1.00	1.00
523	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	20	ANPEP(3), CD2(2), CD33(2), CD5(5), CD7(4), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(2), IL13(2), IL3(1), ITGAX(6), TLR2(3), TLR7(3), TLR9(10)	3351230	49	26	47	29	21	11	3	9	5	0	0.95	1.00	1.00
524	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(7), POLE(14), POLG(4), POLL(1), POLQ(14)	3296060	40	26	40	25	12	10	1	10	7	0	0.98	1.00	1.00
525	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(5), GUSB(3), UGDH(4), UGP2(1), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), XYLB(5)	5195234	42	26	42	18	8	18	1	10	5	0	0.69	1.00	1.00
526	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(1), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), FUT1(2), FUT4(1), FUT7(1), FUT9(3), GCNT2(2), ST3GAL6(2), ST8SIA1(4)	3165155	33	26	32	16	11	9	1	11	1	0	0.83	1.00	1.00
527	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), GOT1(2), GOT2(3), GPT(1), GPT2(3), MDH1(3), MDH2(1), ME1(3), ME3(5), PGK1(1), PGK2(1), PKLR(4), PKM2(2), TKTL1(4), TKTL2(5), TPI1(2)	3980363	51	26	50	24	19	14	4	12	2	0	0.78	1.00	1.00
528	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	21	CSNK2A1(4), ELK1(2), GRB2(1), IL2(1), IL2RA(1), JAK1(4), JAK3(3), JUN(2), LCK(1), MAP2K1(4), MAPK3(1), MAPK8(4), RAF1(6), SHC1(3), SOS1(4), STAT5A(1), STAT5B(4), SYK(3)	4472515	49	26	49	19	9	21	1	12	5	1	0.57	1.00	1.00
529	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(2), CD3E(3), CD3G(2), CD4(3), IFNG(2), IL12B(2), IL12RB1(4), IL12RB2(5), JAK2(8), STAT4(4), TYK2(6)	2899352	42	26	41	17	5	16	3	10	8	0	0.75	1.00	1.00
530	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(5), DNMT1(12), MTNR1A(3), MTNR1B(2), PTAFR(2), PTGDR(5), PTGER2(2), PTGER4(1), PTGFR(3), TBXA2R(7)	2179935	42	26	42	22	15	12	3	10	2	0	0.79	1.00	1.00
531	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), GBA3(1), LPO(2), MPO(5), PRDX6(1), TPO(13), TYR(5)	1904516	31	26	31	17	11	6	0	11	3	0	0.93	1.00	1.00
532	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(3), IKBKB(3), JUN(2), LTA(2), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP3K1(8), MAP3K14(3), MAP4K2(4), MAPK14(1), MAPK8(4), NFKB1(5), RELA(2), TANK(2), TNF(2), TNFRSF1A(3), TRAF2(2)	4745563	54	26	54	21	15	17	1	14	7	0	0.59	1.00	1.00
533	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(3), C9orf95(1), CD38(2), ENPP1(1), ENPP3(3), NADK(3), NADSYN1(5), NMNAT1(1), NMNAT2(1), NMNAT3(1), NNMT(2), NNT(7), NT5C(1), NT5C1A(1), NT5C1B(4), NT5C2(5), NUDT12(1)	4251738	42	25	42	24	13	15	2	8	3	1	0.93	1.00	1.00
534	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(7), GRB2(1), IL3(1), IL3RA(4), JAK2(8), MAP2K1(4), MAPK3(1), PTPN6(3), RAF1(6), SHC1(3), SOS1(4), STAT5A(1), STAT5B(4)	3498185	47	25	47	18	13	18	1	9	6	0	0.56	1.00	1.00
535	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(4), EPX(4), LPO(2), MPO(5), PRDX6(1), SHMT1(1), SHMT2(4), TPO(13)	2326526	35	25	35	14	11	6	2	10	6	0	0.62	1.00	1.00
536	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(2), CDK5R1(1), DAB1(6), FYN(5), LRP8(3), RELN(21), VLDLR(3)	2783276	41	25	41	20	10	16	1	9	5	0	0.84	1.00	1.00
537	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(4), CD44(5), FCGR3A(1), IL1B(1), SELL(4), TGFB1(3), TGFB2(6), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TNFRSF8(2), TNFSF8(1)	2613615	33	25	33	16	10	10	0	8	5	0	0.66	1.00	1.00
538	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(2), AKT2(2), AKT3(3), CDKN1A(1), ELK1(2), GRB2(1), MAP2K1(4), MAP2K2(1), NGFR(5), NTRK1(4), PIK3CD(8), SHC1(3), SOS1(4)	2742270	40	25	39	18	14	16	1	7	2	0	0.68	1.00	1.00
539	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6(1), JAK1(4), JAK2(8), JAK3(3), PIAS3(1), PTPRU(13), REG1A(4), STAT3(7)	3009862	43	25	43	15	13	13	0	13	3	1	0.47	1.00	1.00
540	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(3), CD3G(2), CD8A(2), ICAM1(2), ITGAL(7), ITGB2(6), PTPRC(16)	2128359	40	25	38	18	11	10	1	12	6	0	0.80	1.00	1.00
541	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(2), BAD(1), CHRNG(3), MUSK(5), PIK3R1(7), PTK2(7), PTK2B(8), RAPSN(2), TERT(3), YWHAH(1)	2790018	39	24	39	22	11	11	3	7	7	0	0.94	1.00	1.00
542	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	14	ABL1(2), CDKN2A(4), MDM2(3), PIK3R1(7), POLR1A(8), POLR1B(2), POLR1C(2), POLR1D(1), RB1(8), TBX2(4), TWIST1(1)	3401201	42	24	41	19	10	15	1	7	9	0	0.71	1.00	1.00
543	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(2), CSF1R(7), EGF(5), EGFR(10), GRB2(1), MET(4), PDGFRA(4), SH3GLB1(1), SH3GLB2(3), SH3KBP1(5)	3843415	42	24	42	32	16	9	2	7	8	0	0.99	1.00	1.00
544	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(11), ADRB2(4), CFTR(3), GNAS(14), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6)	2580035	47	24	46	17	19	18	0	7	3	0	0.44	1.00	1.00
545	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(2), BCAT2(1), IARS(7), IARS2(3), ILVBL(3), LARS(3), LARS2(5), PDHA1(1), PDHA2(4), PDHB(2), VARS(8), VARS2(4)	3680181	43	24	43	15	13	10	2	14	4	0	0.55	1.00	1.00
546	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP2(3), ACP5(2), ACP6(3), ACPP(3), ACPT(1), ALPI(4), ALPL(3), ALPP(5), ALPPL2(4), CYP3A4(1), CYP3A43(3), CYP3A5(1), CYP3A7(2), DHRS3(1), DHRS7(1), DHRSX(2), PON1(1), PON2(2)	3543969	42	24	41	17	16	14	1	5	6	0	0.48	1.00	1.00
547	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(4), B3GALNT1(2), B3GALT5(1), FUT1(2), FUT9(3), HEXA(1), HEXB(3), NAGA(3), ST3GAL1(3), ST3GAL2(4), ST8SIA1(4)	2127305	30	24	30	12	11	5	2	11	1	0	0.69	1.00	1.00
548	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(5), ICAM1(2), ITGA4(8), ITGAL(7), ITGB1(4), ITGB2(6), SELE(3), SELL(4)	2407931	39	24	38	17	13	8	2	10	6	0	0.63	1.00	1.00
549	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(3), FUCA1(1), FUCA2(2), GLB1(3), HEXA(1), HEXB(3), LCT(11), MAN2C1(4), MANBA(2), NEU1(1), NEU2(2), NEU3(2), NEU4(2)	3250755	37	24	37	20	17	9	0	6	5	0	0.91	1.00	1.00
550	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), G6PD(2), GPI(4), H6PD(3), PFKM(3), PFKP(8), PGD(1), PGLS(2), PGM1(3), PGM3(6), PRPS1(1), PRPS1L1(2), PRPS2(3), TAL1(1), TALDO1(2)	4028005	52	24	52	23	17	17	2	13	3	0	0.62	1.00	1.00
551	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(2), BAD(1), CASP9(1), CDC42(1), ELK1(2), MAP2K1(4), MAPK3(1), NFKB1(5), PIK3R1(7), RAF1(6), RALBP1(7), RALGDS(7), RELA(2)	3273854	46	24	46	16	12	18	2	7	7	0	0.47	1.00	1.00
552	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(3), CD3G(2), CD4(3), FYN(5), HLA-DRA(3), HLA-DRB1(1), LCK(1), PTPRC(16), ZAP70(4)	1786448	38	24	36	19	7	12	1	13	5	0	0.91	1.00	1.00
553	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), GBA(4), GBA3(1), LPO(2), MPO(5), PRDX6(1), TPO(13)	1660878	30	23	30	13	13	7	0	8	2	0	0.69	1.00	1.00
554	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPL10L(5), RPL12(1), RPL13(1), RPL13A(1), RPL14(1), RPL18A(1), RPL19(2), RPL23A(1), RPL27A(1), RPL3(2), RPL31(1), RPL34(1), RPL36A(1), RPL6(1), RPL8(2), RPL9(2), RPS10(1), RPS11(1), RPS13(1), RPS20(1), RPS23(1), RPS3(1), RPS3A(1), RPS5(2), RPS6(1), RPSA(4)	4478789	39	23	39	19	10	17	1	7	4	0	0.89	1.00	1.00
555	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT5(3), FUT8(3), ST3GAL1(3), ST3GAL2(4), ST3GAL3(2), ST3GAL4(3)	1553428	27	23	26	10	10	8	0	8	1	0	0.59	1.00	1.00
556	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	13	GALNT1(3), GALNT10(3), GALNT2(3), GALNT3(1), GALNT4(1), GALNT6(2), GALNT8(5), GALNT9(3), GCNT1(1), ST3GAL1(3), ST3GAL2(4), ST3GAL4(3)	2616344	32	23	32	11	14	5	2	8	3	0	0.55	1.00	1.00
557	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(2), ATM(17), BCL2(1), CCND1(1), CCNE1(3), CDK2(2), CDKN1A(1), MDM2(3), PCNA(2), RB1(8), TIMP3(2)	3436839	42	23	40	16	10	17	2	5	7	1	0.63	1.00	1.00
558	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(4), MBTPS1(9), MBTPS2(2), SCAP(7), SREBF1(4), SREBF2(7)	2320505	34	23	34	16	11	13	1	7	2	0	0.68	1.00	1.00
559	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(3), CD3G(2), CD4(3), ICAM1(2), ITGAL(7), ITGB2(6), PTPRC(16)	2234803	41	23	39	21	10	11	1	13	6	0	0.92	1.00	1.00
560	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM2(2), CALM3(1), CCL2(1), CCR5(1), CXCR4(2), GNAQ(1), JUN(2), MAPK14(1), MAPK8(4), PLCG1(10), PTK2B(8)	2728483	34	22	33	13	14	10	0	9	1	0	0.48	1.00	1.00
561	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(3), GALNS(2), GLB1(3), GNS(3), GUSB(3), HEXA(1), HEXB(3), IDS(3), IDUA(1), LCT(11), NAGLU(2)	2824541	35	22	35	19	11	14	1	7	2	0	0.85	1.00	1.00
562	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(4), ABCC2(12), ABCG2(3), BCHE(3), CES1(7), CES2(5), CYP3A4(1), CYP3A5(1), UGT1A1(1), UGT1A5(3), UGT1A7(1)	4535993	41	22	41	22	6	19	2	8	6	0	0.88	1.00	1.00
563	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(2), ITGAL(7), ITGAM(5), ITGB2(6), SELE(3), SELL(4)	2073837	32	22	32	18	14	5	1	7	5	0	0.91	1.00	1.00
564	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(2), CREBBP(13), DFFA(2), DFFB(2), GZMA(2), HMGB2(2), PRF1(1), SET(2)	2089941	26	22	26	11	3	9	2	6	6	0	0.75	1.00	1.00
565	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(5), CCNE1(3), CDC34(1), CDK2(2), CUL1(10), RB1(8), SKP2(4), TFDP1(2)	1701327	35	22	34	15	6	12	1	12	4	0	0.69	1.00	1.00
566	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(2), IL13RA2(7), IL4R(1), JAK1(4), JAK2(8), TYK2(6)	2071061	30	22	30	14	7	8	2	8	4	1	0.84	1.00	1.00
567	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(2), IL13RA2(7), IL4R(1), JAK1(4), JAK2(8), TYK2(6)	2071061	30	22	30	14	7	8	2	8	4	1	0.84	1.00	1.00
568	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(4), JAK2(8), JAK3(3), MAPK1(2), MAPK3(1), STAT3(7), TYK2(6)	2302000	31	22	31	14	5	13	0	8	4	1	0.81	1.00	1.00
569	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(4), ALAS1(2), ALAS2(4), CPO(2), FECH(5), GATA1(2), HBB(1), UROD(1), UROS(3)	1559013	24	21	24	10	7	4	2	9	2	0	0.75	1.00	1.00
570	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(5), AGT(2), AGTR2(1), EDN1(3), EDNRA(3), EGF(5), EGFR(10), JUN(2), NFKB1(5), PLCG1(10), RELA(2)	3894831	48	21	47	19	15	9	2	17	5	0	0.60	1.00	1.00
571	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	DUSP1(1), IKBKAP(3), IKBKB(3), MAP3K1(8), MAP3K14(3), NFKB1(5), RELA(2), TNFAIP3(5), TRAF3(2), TRAF6(4)	3601882	36	21	36	12	14	7	2	8	5	0	0.52	1.00	1.00
572	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP51A1(3), DHCR24(2), DHCR7(2), EBP(1), FDPS(4), GGCX(1), GGPS1(2), HMGCR(5), HSD17B7(1), IDI2(1), LSS(5), MVD(2), MVK(4), NQO1(3), NSDHL(3), SC4MOL(2), SC5DL(1), SQLE(4), TM7SF2(1), VKORC1(1)	3821478	48	21	47	20	16	11	3	14	4	0	0.76	1.00	1.00
573	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	DUSP1(1), IKBKAP(3), IKBKB(3), LTA(2), MAP3K1(8), MAP3K14(3), NFKB1(5), RELA(2), TANK(2), TNFAIP3(5), TNFRSF1B(1), TRAF1(2), TRAF2(2), TRAF3(2)	4450001	41	21	41	17	17	10	1	8	5	0	0.68	1.00	1.00
574	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	6	ADCY1(11), CREM(1), FHL5(1), FSHB(2), GNAS(14), XPO1(3)	1609468	32	20	31	11	14	7	0	9	2	0	0.70	1.00	1.00
575	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(4), ALAS1(2), ALAS2(4), CPOX(1), FECH(5), PPOX(2), UROD(1), UROS(3)	1504399	22	20	22	10	6	4	1	9	2	0	0.84	1.00	1.00
576	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(3), HK1(6), HK2(6), HK3(3), IMPA1(3), ISYNA1(2), PGM1(3), PGM3(6), TGDS(2)	2298043	34	20	34	14	14	13	3	2	2	0	0.37	1.00	1.00
577	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(3), CTH(2), GGT1(8), MARS(3), MARS2(1), MAT1A(3), MAT2B(1), PAPSS1(4), PAPSS2(2), SCLY(1), SEPHS1(1)	2439040	29	20	28	14	10	10	1	5	3	0	0.71	1.00	1.00
578	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(2), CDK5R1(1), EGR1(3), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), NGFR(5), RAF1(6)	1610005	25	19	25	15	8	9	1	6	1	0	0.89	1.00	1.00
579	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(5), CCNA2(1), CCND1(1), CCNE1(3), CCNE2(1), CDK2(2), CDKN2A(4), E2F2(2), PRB1(2)	1714247	21	19	21	18	3	8	1	7	2	0	0.99	1.00	1.00
580	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(4), AGT(2), AGTR1(1), AGTR2(1), BDKRB2(3), KNG1(4), NOS3(3), REN(3)	1942346	21	18	21	11	7	7	1	3	3	0	0.71	1.00	1.00
581	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR2(2), ARPC1A(3), ARPC1B(1), ARPC4(1), NCK1(3), NCKAP1(6), NTRK1(4), PSMA7(3), WASF1(4), WASF2(2), WASF3(3), WASL(1)	3016215	34	18	34	28	16	10	1	4	3	0	1.00	1.00	1.00
582	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(3), EGF(5), EGFR(10), HGS(3), RAB5A(2), TF(6), TFRC(1)	2555404	30	18	30	16	5	8	1	11	5	0	0.89	1.00	1.00
583	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(7), FARSA(3), FARSB(1), GOT1(2), GOT2(3), PAH(5), TAT(1), YARS(1), YARS2(1)	1725043	24	18	24	10	8	8	0	6	2	0	0.71	1.00	1.00
584	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(3), HDAC9(1), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), MYOD1(3), YWHAH(1)	1559440	21	18	21	11	9	5	2	4	1	0	0.78	1.00	1.00
585	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(3), CD38(2), ENPP1(1), ENPP3(3), NADSYN1(5), NMNAT1(1), NMNAT2(1), NNMT(2), NNT(7), NT5C(1)	2870773	26	18	26	16	5	9	2	7	2	1	0.96	1.00	1.00
586	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(3), DLL1(3), FURIN(2), NOTCH1(15), PSEN1(1)	1794737	24	18	24	17	10	6	1	4	3	0	0.92	1.00	1.00
587	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAP3K14(3), MAPK14(1), MAPK8(4), NFKB1(5), RELA(2), TNFRSF13B(1), TNFRSF17(1), TRAF2(2), TRAF3(2), TRAF6(4)	2878967	25	18	25	10	5	6	1	10	3	0	0.80	1.00	1.00
588	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(2), HLA-DRA(3), HLA-DRB1(1), IFNG(2), IFNGR1(2), IFNGR2(1), IL12B(2), IL12RB1(4), IL12RB2(5), IL18R1(2), IL2(1), IL2RA(1), IL4R(1)	2513517	27	18	27	13	7	8	2	7	3	0	0.71	1.00	1.00
589	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(2), ARPC1A(3), ARPC1B(1), ARPC4(1), CDC42(1), PAK1(4), PDGFRA(4), PIK3R1(7), WASL(1)	2221445	24	17	24	15	6	11	1	1	5	0	0.94	1.00	1.00
590	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(3), CAPN1(3), CAPNS1(1), CAPNS2(1), CDK5(2), CDK5R1(1), CSNK1D(2), GSK3B(2), MAPT(4), PPP2CA(3)	1836853	22	17	21	13	10	8	0	2	2	0	0.86	1.00	1.00
591	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(9)	2647352	28	17	28	15	10	11	0	5	2	0	0.84	1.00	1.00
592	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(2), BAD(1), BAK1(2), BCL10(1), BCL2(1), BCL2L11(1), BID(1), CASP8AP2(9), CASP9(1), CES1(7)	2231072	26	17	26	10	8	8	0	9	1	0	0.68	1.00	1.00
593	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(2), UBE2A(2), UBE2B(1), UBE2D3(1), UBE2E3(3), UBE2G2(2), UBE2H(1), UBE2I(2), UBE2J2(3), UBE2L3(1), UBE2L6(1), UBE2N(1), UBE3A(5)	2075177	26	17	26	14	9	7	1	5	4	0	0.78	1.00	1.00
594	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	9	B2M(2), CD3E(3), CD3G(2), ICAM1(2), ITGAL(7), ITGB2(6), PRF1(1)	1577249	23	16	22	10	9	5	1	3	5	0	0.76	1.00	1.00
595	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(2), IL13(2), IL16(2), IL2(1), IL3(1), IL6(1), IL8(1), LTA(2), TNF(2)	1974971	20	16	20	10	5	7	1	7	0	0	0.75	1.00	1.00
596	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	10	AKT1(2), GRB2(1), IL4R(1), IRS1(7), JAK1(4), JAK3(3), RPS6KB1(3), SHC1(3)	2787340	24	16	24	19	6	10	0	5	2	1	0.99	1.00	1.00
597	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	CDKN1A(1), EPOR(2), GRIN1(4), HIF1A(2), JAK2(8), NFKB1(5), RELA(2), SOD2(1)	2500547	25	15	25	11	6	8	1	4	6	0	0.79	1.00	1.00
598	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(9), GRHPR(2), HAO1(1), MDH1(3), MDH2(1), MTHFD1(3), MTHFD1L(2), MTHFD2(1)	2532789	22	15	21	13	5	11	1	3	2	0	0.87	1.00	1.00
599	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(9), GRHPR(2), HAO1(1), MDH1(3), MDH2(1), MTHFD1(3), MTHFD1L(2), MTHFD2(1)	2651844	22	15	21	13	5	11	1	3	2	0	0.87	1.00	1.00
600	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(4), ADSS(3), IMPDH1(1), MTHFD2(1), POLD1(7), POLG(4), PRPS2(3), RRM1(4), SRM(1)	2450604	28	15	28	11	8	14	1	3	2	0	0.47	1.00	1.00
601	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(19), RANGAP1(4)	1671751	24	15	22	14	1	10	2	9	2	0	0.92	1.00	1.00
602	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(1), MMP2(4), MMP9(6), RECK(5), TIMP2(1), TIMP3(2)	1483464	19	15	19	12	7	5	0	3	4	0	0.92	1.00	1.00
603	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(2), B3GALT2(5), B3GALT5(1), B3GNT5(1), FUT1(2), ST3GAL3(2), ST3GAL4(3)	1428103	16	14	16	7	8	2	0	6	0	0	0.75	1.00	1.00
604	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(2), BCL2(1), CASP3(1), CASP9(1), CYCS(1), DAXX(3), FAS(3), HSPB1(1), HSPB2(1), MAPKAPK3(3), TNF(2)	2236054	20	14	20	14	8	7	0	3	2	0	0.95	1.00	1.00
605	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), GAD1(3), HDC(5), PNMT(3), TH(1), TPH1(1)	1186592	15	12	15	8	5	4	2	4	0	0	0.81	1.00	1.00
606	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(3), ALDH1A2(5), BCMO1(2), RDH5(2)	770906	12	11	12	11	3	3	0	5	1	0	0.99	1.00	1.00
607	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(3), CD80(1), HLA-DRA(3), HLA-DRB1(1), IL10(1), IL2(1)	791778	10	10	10	6	2	4	0	4	0	0	0.88	1.00	1.00
608	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	EHHADH(2), HADH(2), HADHA(2), HSD17B4(2), NTAN1(2), SIRT1(3), SIRT2(1), SIRT5(3), SIRT7(1), VNN2(1)	2346943	19	10	18	10	3	4	3	4	5	0	0.88	1.00	1.00
609	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(4), AASDH(4), AASS(2), KARS(3)	1384664	13	10	13	9	2	9	1	1	0	0	0.92	1.00	1.00
610	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR2(2), ARPC1A(3), ARPC1B(1), ARPC4(1), CDC42(1), WASF1(4), WASL(1)	1611048	14	9	14	17	6	5	1	1	1	0	1.00	1.00	1.00
611	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(3), CHRNA1(3), SNAP25(1), STX1A(1)	647538	8	8	8	5	3	1	0	4	0	0	0.89	1.00	1.00
612	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(3), PLCD1(1), TGM2(4)	984737	8	8	8	5	6	1	0	1	0	0	0.79	1.00	1.00
613	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(3), HLA-DRA(3), HLA-DRB1(1)	472988	7	7	7	6	1	3	0	3	0	0	0.96	1.00	1.00
614	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(4), RAB27A(3), RAB5A(2), RAB6A(1)	852681	11	7	11	12	2	6	0	2	1	0	0.98	1.00	1.00
615	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(2), ST3GAL3(2)	1007483	4	4	4	6	2	0	0	2	0	0	0.99	1.00	1.00
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		100814	0	0	0	0	0	0	0	0	0	0	1.00	1.00	1.00
