rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(17), CDC25A(2), CDC25B(4), CDC25C(3), CDK2(2), CHEK1(2), MYT1(12), RB1(8), TP53(67), WEE1(1), YWHAH(1)	3508527	119	78	98	12	37	31	5	16	28	2	4.44e-06	<1.00e-15	<1.54e-13
2	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(2), CCND1(1), CDK2(2), CDKN1A(1), CDKN2A(4), CFL1(1), E2F2(2), MDM2(3), NXT1(2), PRB1(2), TP53(67)	1604627	87	72	68	11	27	21	3	12	23	1	0.00016	<1.00e-15	<1.54e-13
3	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	DNAJC3(1), EIF2S1(1), EIF2S2(2), MAP3K14(3), NFKB1(5), RELA(2), TP53(67)	1951817	81	67	62	7	24	16	2	16	22	1	0.00014	<1.00e-15	<1.54e-13
4	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(2), MAX(1), SP1(3), SP3(3), TP53(67), WT1(1)	1390783	77	67	58	9	24	17	2	11	22	1	0.000094	<1.00e-15	<1.54e-13
5	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(17), ATR(5), CDC25C(3), CHEK1(2), CHEK2(5), TP53(67), YWHAH(1)	3188811	100	77	80	11	32	24	4	13	25	2	0.00047	3.44e-15	4.24e-13
6	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(2), CDKN2A(4), MDM2(3), PIK3CA(33), PIK3R1(7), POLR1A(8), POLR1B(2), POLR1C(2), POLR1D(1), RB1(8), TBX2(4), TP53(67), TWIST1(1)	4003294	142	87	108	24	36	48	6	21	30	1	0.000054	2.83e-14	2.91e-12
7	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(2), HSPA1A(1), IFNG(2), IFNGR1(2), IFNGR2(1), IKBKB(3), JAK2(8), LIN7A(6), NFKB1(5), RB1(8), RELA(2), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TP53(67), USH1C(1), WT1(1)	3602378	115	75	94	18	30	27	3	24	30	1	0.00043	8.90e-13	7.83e-11
8	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(10), AKT1(2), ATM(17), CDKN1A(1), CPB2(4), CSNK1D(2), FHL2(2), HIC1(1), HIF1A(2), HSPA1A(1), IGFBP3(4), MAPK8(4), MDM2(3), NFKBIB(4), NQO1(3), TP53(67)	4118242	127	84	107	21	40	33	4	19	29	2	0.00020	1.04e-12	8.00e-11
9	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(2), ATM(17), BRCA1(9), CDKN1A(1), CHEK1(2), CHEK2(5), JUN(2), MAPK8(4), MDM2(3), MRE11A(2), NFKB1(5), RAD50(6), RAD51(1), RBBP8(4), RELA(2), TP53(67), TP73(5)	5915081	137	83	117	21	36	36	5	26	32	2	0.00040	6.69e-11	4.58e-09
10	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(2), APAF1(2), ATM(17), BAD(1), BCL2(1), BID(1), CASP3(1), CASP6(1), CASP7(2), CASP9(1), CYCS(1), EIF2S1(1), PTK2(7), PXN(2), STAT1(6), TLN1(13), TP53(67)	5433042	126	78	106	18	43	32	7	16	26	2	0.000039	1.03e-10	6.37e-09
11	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(13), DAXX(3), PAX3(4), PML(4), RARA(2), RB1(8), SIRT1(3), SP100(7), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TP53(67)	3735247	117	76	97	22	38	26	4	20	28	1	0.0018	3.23e-08	1.78e-06
12	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(2), ATM(17), BCL2(1), CCND1(1), CCNE1(3), CDK2(2), CDKN1A(1), MDM2(3), PCNA(2), RB1(8), TIMP3(2), TP53(67)	3601890	109	76	88	18	31	30	4	15	27	2	0.0017	3.47e-08	1.78e-06
13	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(17), ATR(5), BRCA1(9), BRCA2(17), CHEK1(2), CHEK2(5), FANCA(6), FANCC(2), FANCD2(8), FANCE(1), FANCF(1), FANCG(3), HUS1(1), MRE11A(2), RAD1(1), RAD50(6), RAD51(1), RAD9A(1), TP53(67)	8779376	155	84	135	25	40	50	5	27	31	2	0.00022	0.0027	0.13
14	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(2), CAT(4), GH1(3), GHR(5), IGF1(2), IGF1R(11), PIK3CA(33), PIK3R1(7), SHC1(3), SOD2(1)	2629408	71	41	57	12	12	37	5	10	7	0	0.0018	0.014	0.61
15	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(5)	143247	5	5	5	1	1	0	1	1	2	0	0.55	0.019	0.77
16	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(3), CD3G(2)	225536	5	5	4	1	0	2	1	0	2	0	0.68	0.10	1.00
17	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(3), ERBB4(18), NRG2(5), NRG3(9), PSEN1(1)	1780945	36	27	35	6	8	13	4	7	4	0	0.030	0.19	1.00
18	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(2), DCN(2), FMOD(9), KERA(1), LUM(3)	721456	17	15	17	4	8	3	0	5	1	0	0.29	0.26	1.00
19	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(5), GABRA2(5), GABRA3(5), GABRA4(4), GABRA5(5), GABRA6(5), GPX1(1), PRKCE(6)	1565795	36	24	36	9	13	7	5	10	1	0	0.13	0.28	1.00
20	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(2), BAK1(2), BCL2(1), BID(1), BIRC2(2), BIRC3(4), CASP2(3), CASP3(1), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), FAS(3), JUN(2), MAP2K4(5), MAP3K1(8), MAP3K14(3), MAPK10(3), MDM2(3), NFKB1(5), PARP1(4), PRF1(1), RELA(2), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TNFSF10(2), TP53(67), TRAF1(2), TRAF2(2)	7391990	145	85	126	30	44	35	4	30	31	1	0.0013	0.28	1.00
21	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(5), CPS1(15), GLS(4), GLUD1(4), GOT1(2)	1545002	32	25	32	7	9	9	2	10	2	0	0.14	0.38	1.00
22	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCL5(1), CCR3(4), HLA-DRA(3), HLA-DRB1(1), IL3(1)	602660	11	10	11	3	4	4	0	2	1	0	0.35	0.38	1.00
23	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(4), AKT1(2), ANXA1(3), CALM1(1), CALM2(2), CALM3(1), GNAS(14), GNB1(1), GNGT1(3), NFKB1(5), NOS3(3), NPPA(1), NR3C1(5), PIK3CA(33), PIK3R1(7), RELA(2)	3543596	87	47	72	15	21	37	3	16	10	0	0.0032	0.41	1.00
24	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(2), IL12B(2), IL2(1)	592301	7	7	7	1	0	3	1	3	0	0	0.33	0.42	1.00
25	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3), SUCLA2(3)	416247	6	6	6	0	3	0	0	1	2	0	0.19	0.51	1.00
26	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(2), NR3C1(5), PPARG(1), RXRA(3), TNF(2)	1144281	14	12	14	3	3	4	1	5	1	0	0.26	0.53	1.00
27	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(2), BAD(1), CASP9(1), GH1(3), GHR(5), NFKB1(5), PDPK1(1), PIK3CA(33), PIK3R1(7), PPP2CA(3), RELA(2), YWHAH(1)	2802623	64	35	50	12	11	34	5	8	6	0	0.0083	0.54	1.00
28	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(2), PIK3CA(33), PIK3R1(7), PLCB1(12), PLCG1(10), VAV1(7)	2546225	71	46	56	14	18	32	3	10	8	0	0.013	0.56	1.00
29	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3E(3), CD3G(2), IFNG(2), IL2(1), IL2RA(1), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6), TGFBR3(2), TOB1(1), TOB2(5)	2099747	38	26	37	9	6	15	3	10	4	0	0.21	0.58	1.00
30	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), MIOX(1), UGDH(4)	1679038	29	23	29	5	6	8	0	11	4	0	0.067	0.58	1.00
31	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6)	1120150	22	17	21	5	2	9	0	6	5	0	0.26	0.60	1.00
32	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(4), GAD1(3), GAD2(4), GGT1(8)	1131431	20	17	19	5	9	4	0	7	0	0	0.24	0.60	1.00
33	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(4), ELK1(2), GRB2(1), JUN(2), MAP2K1(4), MAPK3(1), MAPK8(4), NGFR(5), PIK3CA(33), PIK3R1(7), PLCG1(10), RAF1(6), SHC1(3), SOS1(4)	3777413	86	43	71	17	19	41	4	15	7	0	0.0044	0.67	1.00
34	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(3), IL8(1), SLPI(1)	339001	5	4	5	2	2	2	0	1	0	0	0.67	0.68	1.00
35	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP3(1), CASP8(6), CFL1(1)	763348	9	8	9	2	1	2	1	3	2	0	0.53	0.69	1.00
36	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(2), HLA-A(10), ITGB1(4), KLRC1(2), KLRC2(2), KLRD1(2), MAP2K1(4), MAPK3(1), PAK1(4), PIK3CA(33), PIK3R1(7), PTK2B(8), PTPN6(3), SYK(3), VAV1(7)	3688406	92	55	77	21	14	40	7	18	13	0	0.024	0.70	1.00
37	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(2), BAD(1), CASP9(1), CDC42(1), ELK1(2), MAP2K1(4), MAPK3(1), NFKB1(5), PIK3CA(33), PIK3R1(7), RAF1(6), RALBP1(7), RALGDS(7), RELA(2), RHOA(8)	3790430	87	45	69	19	17	43	5	14	8	0	0.011	0.73	1.00
38	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(1), TGDS(2), UGDH(4), UXS1(3)	777847	11	10	11	3	4	3	1	2	1	0	0.44	0.77	1.00
39	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(1), FLT3(7), IGF1(2), IL11(2), IL3(1), IL6(1), KITLG(3), TGFB1(3), TGFB2(6), TGFB3(4)	1643883	30	22	30	7	7	11	0	8	4	0	0.19	0.78	1.00
40	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4)	2628366	47	29	46	9	7	15	0	16	9	0	0.047	0.78	1.00
41	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1R(5), C1S(4), C2(2), C3(16), C5(9), C6(8), C7(2), C8A(6), C8B(8), C9(3), MASP1(4)	4166093	68	37	67	14	20	15	3	20	9	1	0.040	0.81	1.00
42	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(2)	320318	3	3	3	0	2	1	0	0	0	0	0.32	0.82	1.00
43	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(1), CASP7(2), DFFA(2), DFFB(2), ENDOG(1), HMGB2(2), TOP2A(6), TOP2B(10)	1886072	26	16	23	4	4	10	1	4	7	0	0.15	0.83	1.00
44	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOB(4), ALDOC(3), TPI1(2)	769932	10	9	10	2	2	3	0	5	0	0	0.35	0.84	1.00
45	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(2), BCAR1(4), GRB2(1), ILK(2), ITGB1(4), MAPK1(2), MAPK3(1), PDPK1(1), PIK3CA(33), PIK3R1(7), PTEN(8), PTK2(7), SHC1(3), SOS1(4)	3802640	79	44	64	15	10	38	7	11	13	0	0.0058	0.85	1.00
46	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(4), GLS2(5), GLUD1(4), GLUD2(7)	895266	20	14	20	5	6	6	0	7	1	0	0.29	0.85	1.00
47	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(4), GRB2(1), JAK2(8), JUN(2), MAP2K1(4), MAPK3(1), PIK3CA(33), PIK3R1(7), PLCG1(10), RAF1(6), RASA1(10), SHC1(3), SOS1(4), STAT1(6), STAT3(7), STAT5A(1), STAT5B(4), THPO(2)	5938169	113	48	97	21	24	50	6	17	15	1	0.00091	0.85	1.00
48	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(3), HLCS(1), SPCS3(1)	613372	5	5	5	0	3	0	0	2	0	0	0.15	0.86	1.00
49	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(4), GGPS1(2), IDI2(1), SQLE(4)	859784	11	9	10	2	4	2	0	2	3	0	0.38	0.87	1.00
50	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(2), CREB1(4), GRB2(1), MAPK1(2), MAPK3(1), MAPK7(8), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), NTRK1(4), PIK3CA(33), PIK3R1(7), PLCG1(10), RPS6KA1(6), SHC1(3)	3738987	93	45	78	18	27	43	4	11	8	0	0.0012	0.87	1.00
51	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(2), EIF2B5(4), EIF2S1(1), EIF2S2(2), EIF2S3(1), EIF4E(1), EIF4EBP1(1), GSK3B(2), IGF1(2), IGF1R(11), INPPL1(13), PDPK1(1), PIK3CA(33), PIK3R1(7), PPP2CA(3), PTEN(8), RPS6(1), RPS6KB1(3)	3901424	96	49	81	19	24	40	5	14	13	0	0.0046	0.88	1.00
52	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(8), HSD17B1(3), HSD17B2(1), HSD17B3(2), HSD17B4(2), HSD17B7(1), HSD3B1(1), HSD3B2(1)	1609144	21	19	21	5	4	8	1	4	4	0	0.14	0.89	1.00
53	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), CD36(2), FYN(5), JUN(2), MAPK14(1), THBS1(9)	1459365	20	15	20	4	6	7	0	5	2	0	0.13	0.90	1.00
54	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(20), CDH1(14), CREBBP(13), EP300(15), MAP2K1(4), MAP3K7(7), MAPK3(1), SKIL(3), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6)	5081852	98	51	97	24	17	33	5	21	21	1	0.081	0.90	1.00
55	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(3), PDXK(4), PDXP(1), PNPO(1), PSAT1(2)	954275	11	10	11	4	2	3	0	3	2	1	0.59	0.90	1.00
56	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(3), PARK2(9), SNCAIP(7), UBE2F(3), UBE2G2(2), UBE2L3(1), UBE2L6(1)	1271878	26	20	26	6	9	9	0	5	3	0	0.11	0.91	1.00
57	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(6), AOC2(4), AOC3(3), CES1(7), ESD(1)	1196455	21	16	21	6	4	7	1	8	0	1	0.38	0.93	1.00
58	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(3), CCL2(1), IL6(1), LDLR(4), LPL(2)	1053715	11	11	11	4	3	2	0	3	3	0	0.50	0.93	1.00
59	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(4), CD4(3), HLA-DRA(3), HLA-DRB1(1), IL1B(1), IL5RA(1), IL6(1)	1061395	15	13	15	5	3	5	0	5	2	0	0.52	0.93	1.00
60	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(2), FOSB(2), GRIA2(13)	739892	17	13	17	6	5	9	0	2	1	0	0.42	0.94	1.00
61	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1), LIPT1(3)	303839	4	4	4	2	0	2	0	1	1	0	0.75	0.94	1.00
62	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(2), GRB2(1), NTRK1(4), PIK3CA(33), PIK3R1(7), PLCG1(10), SHC1(3), SOS1(4)	3079735	64	38	49	13	13	34	3	8	6	0	0.015	0.94	1.00
63	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(9), FH(2), IDH1(1), IDH2(1), MDH1(3), MDH2(1), SDHB(4), SUCLA2(3)	1762795	24	18	23	4	10	5	2	5	2	0	0.066	0.94	1.00
64	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(3), HGD(2)	443440	7	6	7	4	4	0	0	3	0	0	0.84	0.94	1.00
65	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(1), ACADS(1), ACAT1(3), HADHA(2)	1072173	9	7	8	2	2	3	0	0	4	0	0.28	0.95	1.00
66	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(5), GABRA1(5), GABRA2(5), GABRA3(5), GABRA4(4), GABRA5(5), GABRA6(5), GPHN(7), NSF(2), UBQLN1(4)	2375572	47	27	47	12	11	10	7	13	6	0	0.17	0.95	1.00
67	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(2), COQ3(2), COQ6(3), COQ7(1), NDUFA13(1)	796152	9	8	9	3	4	4	0	1	0	0	0.60	0.95	1.00
68	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS1(4), PAPSS2(2), SULT1A2(4), SULT1E1(3), SULT2A1(1)	1211968	16	12	16	4	7	8	0	0	1	0	0.31	0.95	1.00
69	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1R(5), C1S(4), C2(2), C3(16), C5(9), C6(8), C7(2), C8A(6), C9(3), MASP1(4), MASP2(2), MBL2(1)	4268350	63	34	63	14	18	16	3	17	8	1	0.057	0.95	1.00
70	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(4), SQLE(4)	645123	8	6	8	2	3	2	0	2	1	0	0.46	0.96	1.00
71	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(3), MTMR1(3), MTMR2(3), MTMR6(4), NFS1(2), PHPT1(3), THTPA(1), TPK1(2)	1276237	21	13	21	4	7	10	1	2	1	0	0.14	0.96	1.00
72	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(6), CYP2C9(1)	401261	7	6	7	3	2	1	0	4	0	0	0.80	0.96	1.00
73	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(2), CD3E(3), CD3G(2), CD4(3), CD58(1), CD8A(2), CSF3(1), IL3(1), IL6(1), IL8(1), KITLG(3)	1228410	22	18	21	8	3	8	1	6	4	0	0.63	0.96	1.00
74	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(4), CTH(2), GOT1(2), GOT2(3), LDHB(2), LDHC(1), MPST(1)	1332052	15	12	15	3	5	6	1	1	2	0	0.16	0.96	1.00
75	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(16), C5(9), C6(8), C7(2), C8A(6), C9(3)	2519797	44	28	44	11	14	11	2	12	5	0	0.14	0.97	1.00
76	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(2), CAMP(1), DAG1(7), GNAQ(1), ITPKA(1), ITPKB(6)	1188008	18	16	18	6	6	5	0	4	2	1	0.50	0.97	1.00
77	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(2), BAD(1), BAK1(2), BCL2(1), BCL2L11(1), BID(1), BIRC2(2), BIRC3(4), BIRC5(1), CASP1(2), CASP10(3), CASP2(3), CASP3(1), CASP4(2), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), DFFA(2), DFFB(2), FAS(3), HELLS(3), IKBKB(3), IRF1(1), IRF2(10), IRF3(3), IRF4(2), IRF5(2), IRF6(2), IRF7(1), JUN(2), LTA(2), MAP2K4(5), MAP3K1(8), MAPK10(3), MDM2(3), NFKB1(5), NFKBIB(4), PLEKHG5(5), PRF1(1), RELA(2), TNF(2), TNFRSF10B(2), TNFRSF1A(3), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(2), TNFSF10(2), TP53(67), TP73(5), TRAF1(2), TRAF2(2), TRAF3(2)	11314933	204	89	185	43	64	53	6	41	38	2	0.00026	0.97	1.00
78	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(2)	356672	4	3	4	2	2	1	1	0	0	0	0.73	0.97	1.00
79	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1R(5), C1S(4), C2(2), C3(16), C5(9), C6(8), C7(2), C8A(6), C9(3)	3511720	56	32	56	13	16	13	3	16	7	1	0.11	0.97	1.00
80	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(1), TGDS(2), UGDH(4), UGP2(1), UXS1(3)	986258	12	11	12	4	5	3	1	2	1	0	0.51	0.98	1.00
81	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(2), IFNGR2(1), JAK1(4), JAK2(8), STAT1(6)	1630706	23	15	23	7	5	8	1	5	3	1	0.42	0.98	1.00
82	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(2), BIRC3(4), CASP8(6), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF2(2)	1640439	20	17	20	6	6	4	1	7	2	0	0.39	0.98	1.00
83	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(6), BMPR1A(1), BMPR1B(3), BMPR2(10)	1235622	20	16	19	6	7	6	0	3	2	2	0.53	0.98	1.00
84	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(4), ALPL(3), ALPP(5), ALPPL2(4), FPGS(1), GGH(1), SPR(2)	1274303	20	15	19	7	11	3	0	3	3	0	0.36	0.98	1.00
85	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(2), CREB1(4), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K6(2), MAP3K1(8), MAPK1(2), MAPK14(1), MAPK3(1), NFKB1(5), PIK3CA(33), PIK3R1(7), RB1(8), RELA(2), SP1(3)	3851045	84	39	69	16	14	42	4	13	11	0	0.0046	0.98	1.00
86	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), CHPT1(1), LCMT1(1), LCMT2(7), METTL6(1), PCYT1A(7), PCYT1B(3), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), WBSCR22(2)	2787562	38	24	38	7	13	12	1	7	5	0	0.031	0.98	1.00
87	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(11), GNAS(14), GNB1(1), GNGT1(3), PRKACA(1), PRKAR1A(2)	1300583	32	18	31	9	16	8	0	4	4	0	0.33	0.98	1.00
88	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(2), BAK1(2), BCL2(1), BID(1), BIRC2(2), BIRC3(4), CASP3(1), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), DFFA(2), DFFB(2), DIABLO(1), ENDOG(1)	2685524	30	20	30	4	7	11	1	7	4	0	0.048	0.98	1.00
89	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4)	1574973	32	23	32	10	7	7	0	13	5	0	0.42	0.99	1.00
90	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4)	1574973	32	23	32	10	7	7	0	13	5	0	0.42	0.99	1.00
91	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(4), ELK1(2), GRB2(1), INSR(10), IRS1(7), JUN(2), MAP2K1(4), MAPK3(1), MAPK8(4), PIK3CA(33), PIK3R1(7), PTPN11(4), RAF1(6), RASA1(10), SHC1(3), SLC2A4(1), SOS1(4), SRF(1)	5042175	104	50	89	23	23	45	5	16	14	1	0.0035	0.99	1.00
92	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(1), HS3ST1(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), XYLT1(7), XYLT2(4)	1263913	25	18	25	7	11	9	1	1	3	0	0.23	0.99	1.00
93	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(1), HS3ST1(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), XYLT1(7), XYLT2(4)	1263913	25	18	25	7	11	9	1	1	3	0	0.23	0.99	1.00
94	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25A(2), CDC25B(4), CDC25C(3), CSK(3), GRB2(1), PTPRA(5)	1823577	19	14	19	3	7	5	0	1	6	0	0.070	0.99	1.00
95	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(1), GGT1(8), SHMT1(1), SHMT2(4)	818435	14	14	13	6	4	1	1	5	3	0	0.62	0.99	1.00
96	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	RB1(8), SP1(3), SP3(3)	1320400	14	12	13	4	1	8	0	2	3	0	0.39	0.99	1.00
97	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(2), CDC25B(4), CDKN1A(1), CHEK1(2), NEK1(4), WEE1(1)	1397462	14	12	14	3	2	5	0	3	4	0	0.46	0.99	1.00
98	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(4), ELK1(2), GRB2(1), IGF1(2), IGF1R(11), IRS1(7), JUN(2), MAP2K1(4), MAPK3(1), MAPK8(4), PIK3CA(33), PIK3R1(7), PTPN11(4), RAF1(6), RASA1(10), SHC1(3), SOS1(4), SRF(1)	4907148	106	48	91	23	22	47	5	19	12	1	0.0040	0.99	1.00
99	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(3), ACAT2(3), ACYP2(1), EHHADH(2), GCDH(3), HADHA(2), SDHB(4), SDS(1)	1546604	19	12	18	4	4	10	2	0	3	0	0.084	0.99	1.00
100	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD3E(3), CD3G(2), CD4(3)	638386	9	8	8	7	0	4	1	2	2	0	0.98	0.99	1.00
101	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), FUT1(2), FUT9(3), GCNT2(2), ST8SIA1(4)	1209262	12	10	12	4	3	3	0	6	0	0	0.56	0.99	1.00
102	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(1), ACADS(1), ACSL1(2), ACSL3(6), ACSL4(3), CPT1A(4), CPT2(4), EHHADH(2), HADHA(2), SCP2(3), SLC25A20(2)	3333189	32	19	31	6	6	7	3	7	9	0	0.083	0.99	1.00
103	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(4), F13A1(9), F2(4), F2R(2), FGA(5), FGB(3), FGG(2), PLAT(2), PLAU(2), PLG(10), SERPINB2(3), SERPINE1(2)	2657223	48	30	48	12	14	13	2	11	8	0	0.085	0.99	1.00
104	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(2), COASY(1), DPYD(13), DPYS(2), ENPP1(1), ENPP3(3), PANK1(2), PANK2(2), PANK4(3), UPB1(2)	2757218	31	24	31	7	8	9	1	8	5	0	0.099	0.99	1.00
105	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(13), EP300(15), ESR1(5), MAPK1(2), MAPK3(1), PELP1(6)	2887230	42	26	41	9	11	12	1	5	13	0	0.099	0.99	1.00
106	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), GPR109B(2), GPR161(2), GPR39(6), GPR45(4), GPR68(4), GPR75(5), GPR81(2)	1956733	27	18	27	8	13	5	2	6	1	0	0.18	0.99	1.00
107	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(1), EPHX2(4), HSD3B7(3), RDH11(1), RDH12(1)	948226	10	9	10	4	2	4	0	4	0	0	0.61	1.00	1.00
108	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(4), GBA3(1), GGT1(8), SHMT1(1), SHMT2(4)	1094074	19	17	18	7	7	3	1	5	3	0	0.45	1.00	1.00
109	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CCNH(2), CDC25A(2), CDC25B(4), CDC25C(3), MNAT1(2), XPO1(3)	1711745	17	11	17	3	6	3	1	3	4	0	0.15	1.00	1.00
110	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(2), BAD(1), GRB2(1), IGF1R(11), IRS1(7), MAP2K1(4), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3R1(7), RAF1(6), SHC1(3), SOS1(4), YWHAH(1)	3756942	83	43	69	20	15	44	4	12	8	0	0.023	1.00	1.00
111	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(3), TAT(1)	519281	6	6	6	3	2	2	0	1	1	0	0.77	1.00	1.00
112	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(17), ATR(5), BRCA1(9), CCNB1(1), CDC25A(2), CDC25B(4), CDC25C(3), CDC34(1), CDKN1A(1), CDKN2D(1), CHEK1(2), CHEK2(5), EP300(15), MDM2(3), MYT1(12), PRKDC(22), RPS6KA1(6), TP53(67), WEE1(1), YWHAH(1), YWHAQ(2)	8422450	180	87	160	37	56	51	6	26	39	2	0.0015	1.00	1.00
113	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(2), BCAT2(1), COASY(1), DPYD(13), DPYS(2), ENPP1(1), ENPP3(3), ILVBL(3), PANK1(2), PANK2(2), PANK4(3), PPCDC(1), UPB1(2), VNN1(1)	3426026	37	24	37	7	13	10	1	8	5	0	0.029	1.00	1.00
114	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), IL1B(1), MST1(2), MST1R(8), TNF(2)	1290930	14	13	14	4	6	4	0	3	1	0	0.33	1.00	1.00
115	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(4), JUN(2), KEAP1(6), MAPK1(2), MAPK14(1), MAPK8(4), NFE2L2(1)	1735891	20	15	20	6	6	9	0	4	1	0	0.29	1.00	1.00
116	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), CYCS(1), GPD2(3), NDUFA1(1), SDHA(5), SDHB(4), SDHC(1), UQCRC1(2)	1310265	18	14	18	5	6	5	2	3	2	0	0.29	1.00	1.00
117	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(2), IFNGR1(2), JAK1(4), JAK2(8), PTPRU(13), REG1A(4), STAT1(6)	2271344	41	23	41	10	14	10	1	11	4	1	0.17	1.00	1.00
118	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(3), ACAT2(3), HMGCL(1), OXCT1(4)	669444	11	9	11	5	3	6	0	1	1	0	0.74	1.00	1.00
119	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3E(3), CD3G(2), CD80(1), CD86(2), CTLA4(3), GRB2(1), HLA-DRA(3), HLA-DRB1(1), ICOS(1), IL2(1), ITK(4), LCK(1), PIK3CA(33), PIK3R1(7), PTPN11(4)	2540642	67	43	52	17	11	33	5	11	7	0	0.090	1.00	1.00
120	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(4), ALOX15(2), ALOX15B(1), ALOX5(6), ALOX5AP(2), DPEP1(1), GGT1(8), LTA4H(4), PLA2G6(3), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(2)	2959416	45	30	44	11	17	11	3	11	3	0	0.094	1.00	1.00
121	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(3), CBS(3), CTH(2), MUT(3)	962808	11	10	11	9	3	3	1	1	3	0	0.98	1.00	1.00
122	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(2), IFNAR1(5), IFNAR2(4), IFNB1(2), MAPK8(4), NFKB1(5), RELA(2), TNFRSF11A(4), TNFSF11(1), TRAF6(4)	2201392	33	19	33	9	8	10	1	9	5	0	0.27	1.00	1.00
123	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(3), ST3GAL1(3), ST3GAL2(4), ST3GAL4(3), ST3GAL5(1), ST6GALNAC2(1), ST6GALNAC4(2), ST8SIA1(4)	1117798	21	20	21	8	10	4	0	7	0	0	0.49	1.00	1.00
124	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(2), GOSR1(2), GOSR2(2), SNAP25(1), SNAP29(3), STX10(3), STX11(2), STX16(3), STX17(1), STX18(2), STX19(3), STX2(1), STX3(1), STX4(1), STX5(2), STX6(3), STX7(1), STX8(1), TSNARE1(7), USE1(2), VAMP4(1), VAMP5(1), VAMP7(2), VTI1B(1), YKT6(1)	3290008	49	28	49	10	19	16	2	10	2	0	0.045	1.00	1.00
125	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(15), CPT1A(4), LEPR(8), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2)	2870839	37	19	37	9	15	8	2	5	7	0	0.15	1.00	1.00
126	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX1(2), ACOX3(5), ELOVL2(1), ELOVL5(2), FADS1(2), FADS2(4), FASN(11), HADHA(2), HSD17B12(2), SCD(4)	2800812	36	19	34	9	13	8	1	8	6	0	0.16	1.00	1.00
127	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(6), LCT(11), PGM1(3), PYGL(5), PYGM(7), TPI1(2), TREH(4)	2645520	38	23	38	10	19	10	1	4	4	0	0.14	1.00	1.00
128	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(4), AASS(2), KARS(3)	939489	9	6	9	4	2	5	1	1	0	0	0.70	1.00	1.00
129	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3E(3), CD3G(2), HLA-A(10), ICAM1(2), ITGAL(7), ITGB2(6), PRF1(1)	1722052	33	23	32	11	9	7	4	6	7	0	0.50	1.00	1.00
130	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(3), GOT1(2), GOT2(3), TAT(1), TYR(5)	931324	14	14	14	6	3	5	0	4	2	0	0.73	1.00	1.00
131	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(3), GNAS(14), GNB1(1), GNGT1(3), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6)	1891791	36	25	35	10	14	9	1	8	4	0	0.30	1.00	1.00
132	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(3), PSMA6(3), PSMA7(3), PSMB2(1), PSMB3(1), PSMB4(1), PSMC3(6), RPN1(1), RPN2(3), UBE2A(2), UBE3A(5)	2570573	32	18	32	8	7	12	4	5	4	0	0.16	1.00	1.00
133	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IKBKB(3), IL1R1(3), IRAK1(5), MAP3K1(8), MAP3K14(3), MAP3K7(7), MYD88(2), NFKB1(5), RELA(2), TLR4(13), TNF(2), TNFAIP3(5), TNFRSF1A(3), TNFRSF1B(1), TRAF6(4)	4797754	66	39	64	17	19	15	7	18	7	0	0.11	1.00	1.00
134	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(2), CDC42(1), DLD(2), DUSP10(3), DUSP4(1), DUSP8(1), GAB1(1), GCK(3), IL1R1(3), JUN(2), MAP2K4(5), MAP2K5(1), MAP2K7(13), MAP3K1(8), MAP3K10(6), MAP3K11(3), MAP3K12(4), MAP3K13(5), MAP3K2(2), MAP3K3(2), MAP3K4(10), MAP3K5(3), MAP3K7(7), MAP3K9(5), MAPK10(3), MAPK7(8), MAPK8(4), MAPK9(3), MYEF2(4), NFATC3(3), NR2C2(3), PAPPA(14), SHC1(3), TP53(67), TRAF6(4), ZAK(3)	9952654	212	85	193	47	65	59	9	37	41	1	0.00057	1.00	1.00
135	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(2), HADHA(2), SDS(1)	961259	5	3	4	4	0	3	0	0	2	0	0.88	1.00	1.00
136	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(2), BCL2(1), BCR(7), GRB2(1), JAK2(8), JUN(2), MAP2K1(4), MAP2K4(5), MAP3K1(8), MAPK3(1), MAPK8(4), PIK3CA(33), PIK3R1(7), RAF1(6), SOS1(4), STAT1(6), STAT5A(1), STAT5B(4)	5559207	104	46	90	26	22	48	4	15	15	0	0.016	1.00	1.00
137	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(4), NR0B2(2), NR1H3(2), NR1H4(3), RXRA(3)	1078636	17	14	17	7	7	3	0	5	2	0	0.54	1.00	1.00
138	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP2(3), ACP5(2), ACP6(3), ACPP(3), ACPT(1), ENPP1(1), ENPP3(3), FLAD1(2), LHPP(3), MTMR1(3), MTMR2(3), MTMR6(4), PHPT1(3), RFK(1), TYR(5)	2957473	40	25	40	10	10	17	2	8	3	0	0.12	1.00	1.00
139	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), ARG1(2), GLS(4), GLUD1(4)	1091327	12	9	12	5	4	4	0	3	1	0	0.59	1.00	1.00
140	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(17), CR2(4), FCGR2B(1), HLA-DRA(3), HLA-DRB1(1), ICAM1(2), ITGAL(7), ITGB2(6), PTPRC(16)	3026176	58	35	56	17	17	17	0	17	5	2	0.19	1.00	1.00
141	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(6), ADC(1), AGMAT(2), ALDH18A1(4), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), AMD1(2), AOC2(4), AOC3(3), ARG1(2), ASL(5), ASS1(6), CPS1(15), GATM(2), MAOA(1), MAOB(3), NAGS(1), ODC1(3), OTC(2), SAT1(1), SMS(2), SRM(1)	5832810	90	42	90	22	25	26	5	27	6	1	0.033	1.00	1.00
142	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(1), NDUFA8(1), NDUFB2(1), NDUFB7(1), NDUFS1(5), NDUFS2(2), NDUFV1(1)	1365674	13	12	13	4	1	5	2	3	2	0	0.54	1.00	1.00
143	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(4), GRB2(1), HBXIP(1), PTK2B(8), SHC1(3), SOS1(4)	1748610	21	14	21	7	5	8	0	3	5	0	0.49	1.00	1.00
144	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(5), PLCB1(12), RELA(2)	1636017	20	15	20	7	6	5	0	5	4	0	0.64	1.00	1.00
145	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(1), ENO3(3), FARS2(7), GOT1(2), GOT2(3), PAH(5), TAT(1), YARS(1)	1645117	26	18	26	9	8	10	0	5	3	0	0.45	1.00	1.00
146	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(2), DHRS3(1), DHRS7(1), DHRSX(2), LCMT1(1), LCMT2(7), METTL6(1), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), WBSCR22(2)	2969307	31	21	31	8	8	11	1	6	5	0	0.16	1.00	1.00
147	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(4), CYP11A1(2), CYP11B2(2), CYP17A1(2), HSD11B1(1), HSD11B2(2), HSD3B1(1), HSD3B2(1)	1371346	15	11	15	5	5	3	1	5	1	0	0.42	1.00	1.00
148	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(2), ACAD9(2), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), DHRS3(1), DHRS7(1), DHRSX(2), ESCO2(2), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), SH3GLB1(1)	4959740	64	35	63	16	14	24	4	14	8	0	0.066	1.00	1.00
149	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(13), EP300(15), LPL(2), NCOA1(11), NCOA2(12), PPARG(1), RXRA(3)	3665194	57	30	57	14	10	25	3	8	11	0	0.060	1.00	1.00
150	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), EHHADH(2), HADHA(2), SDS(1)	2402157	37	24	36	13	7	10	0	13	7	0	0.47	1.00	1.00
151	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(2), BIRC2(2), BIRC3(4), CASP3(1), CASP8(6), JUN(2), MAP2K4(5), MAP3K3(2), MAP3K7(7), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), NR2C2(3), RALBP1(7), TNF(2), TNFAIP3(5), TNFRSF1A(3), TNFRSF1B(1), TRAF2(2)	5364016	72	31	72	15	24	18	4	16	10	0	0.019	1.00	1.00
152	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(2), ATM(17), ATR(5), CCNA1(5), CCND1(1), CCNE1(3), CDC25A(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(4), GSK3B(2), HDAC1(2), RB1(8), SKP2(4), TFDP1(2), TGFB1(3), TGFB2(6), TGFB3(4), TP53(67)	5991513	144	83	123	35	40	38	4	30	30	2	0.032	1.00	1.00
153	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(2), CALM1(1), CALM2(2), CALM3(1), ELK1(2), FCER1A(1), GRB2(1), JUN(2), LYN(4), MAP2K1(4), MAP2K4(5), MAP2K7(13), MAP3K1(8), MAPK1(2), MAPK3(1), MAPK8(4), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), PAK2(5), PIK3CA(33), PIK3R1(7), PLA2G4A(3), PLCG1(10), PPP3CA(3), PPP3CB(1), RAF1(6), SHC1(3), SOS1(4), SYK(3), VAV1(7)	8492062	169	60	154	35	45	69	5	27	23	0	0.00013	1.00	1.00
154	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACAA2(1), ACADL(2), ACADM(1), ACADS(1), ACADSB(3), ACAT1(3), ACAT2(3), ACOX1(2), ACOX3(5), ACSL1(2), ACSL3(6), ACSL4(3), ACSL5(2), ACSL6(5), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), CPT1A(4), CPT1B(4), CPT1C(4), CPT2(4), CYP4A11(1), CYP4A22(1), EHHADH(2), GCDH(3), HADH(2), HADHA(2), HADHB(2), HSD17B4(2)	9703020	118	45	116	27	23	37	4	31	23	0	0.0078	1.00	1.00
155	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(3), CSF3(1), HLA-DRA(3), HLA-DRB1(1), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL11(2), IL12B(2), IL13(2), IL2(1), IL3(1), IL6(1), IL8(1), LTA(2), PDGFA(1), TGFB1(3), TGFB2(6), TGFB3(4), TNF(2)	2644219	42	32	42	14	9	17	1	13	2	0	0.39	1.00	1.00
156	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(4), CRK(1), CXCR4(2), GNAI1(1), GNAQ(1), GNB1(1), GNGT1(3), MAP2K1(4), MAPK1(2), MAPK3(1), NFKB1(5), PIK3C2G(3), PIK3CA(33), PIK3R1(7), PLCG1(10), PTK2(7), PTK2B(8), PXN(2), RAF1(6), RELA(2)	5493351	103	49	88	27	23	40	7	18	15	0	0.041	1.00	1.00
157	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(17), CDC25A(2), CDC25B(4), CDC25C(3), CHEK1(2), MYT1(12), WEE1(1), YWHAH(1)	2743585	42	26	41	10	16	14	2	4	5	1	0.12	1.00	1.00
158	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(1), CHST12(6), CHST13(1), PAPSS1(4), PAPSS2(2), SULT1A1(2), SULT1A2(4), SULT1E1(3), SULT2A1(1)	1818696	26	16	26	8	11	10	1	2	2	0	0.28	1.00	1.00
159	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(6), CALCR(4), CALCRL(5), CD97(2), CRHR1(2), CRHR2(3), ELTD1(9), EMR1(10), EMR2(3), GLP1R(1), GLP2R(4), GPR64(6), LPHN1(6), LPHN2(11), LPHN3(11), SCTR(2), VIPR1(4), VIPR2(4)	5281281	93	43	93	24	23	28	6	30	6	0	0.041	1.00	1.00
160	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(3), CDC34(1), CDK2(2), CUL1(10), FBXW7(11), RB1(8), TFDP1(2)	1646571	37	20	34	12	10	12	1	8	6	0	0.32	1.00	1.00
161	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	FH(2), IDH2(1), MDH1(3), OGDH(8), SDHA(5), SUCLA2(3)	1855116	22	18	21	8	8	5	1	4	4	0	0.60	1.00	1.00
162	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(2), IARS(7), LARS(3), LARS2(5), PDHA1(1), PDHA2(4), PDHB(2)	1991199	24	19	24	8	2	7	1	11	3	0	0.61	1.00	1.00
163	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(4), CYP2A6(2), CYP2A7(3), NAT1(1), NAT2(5), XDH(9)	1582599	27	21	26	9	9	13	1	4	0	0	0.29	1.00	1.00
164	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(4), ENO1(3), GPI(4), HK1(6), PFKL(7), PGK1(1), PKLR(4), TPI1(2)	1822060	31	21	31	10	12	13	1	5	0	0	0.20	1.00	1.00
165	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(3), PSMA6(3), PSMA7(3), PSMB10(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB8(2), PSMB9(1)	1729676	19	9	19	7	7	6	2	2	2	0	0.55	1.00	1.00
166	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAA2(1), ACAT1(3), ACAT2(3), EHHADH(2), HADHA(2), HADHB(2), SDS(1)	1656270	15	9	14	5	1	8	0	2	4	0	0.41	1.00	1.00
167	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(2), ARHGAP5(6), CASP1(2), CASP10(3), CASP3(1), CASP8(6), CASP9(1), CYCS(1), JUN(2), PRF1(1)	2555679	25	17	25	8	5	5	2	8	4	1	0.61	1.00	1.00
168	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(2), AKT2(2), AKT3(3), CDKN1A(1), ELK1(2), GRB2(1), MAP2K1(4), MAP2K2(1), NGFR(5), NTRK1(4), PIK3CA(33), PIK3CD(8), SHC1(3), SOS1(4)	3179312	73	40	58	21	19	36	4	11	3	0	0.080	1.00	1.00
169	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(5), ESR2(6), ITPKA(1), PDE1A(3), PDE1B(2), PLCB1(12), PLCB2(4), PRL(2), TRH(3), VIP(1)	2190469	39	27	38	12	12	12	2	8	5	0	0.33	1.00	1.00
170	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(5), NR1I3(3), PTGS1(5), PTGS2(2)	1057946	18	14	18	8	8	6	1	2	1	0	0.67	1.00	1.00
171	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(3), GHR(5), GRB2(1), INSR(10), IRS1(7), JAK2(8), MAP2K1(4), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3R1(7), PLCG1(10), PTPN6(3), RAF1(6), RPS6KA1(6), SHC1(3), SLC2A4(1), SOCS1(1), SOS1(4), SRF(1), STAT5A(1), STAT5B(4)	6542180	121	49	106	28	32	53	5	18	13	0	0.0036	1.00	1.00
172	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(16), GNA12(1), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAR2A(1), PRKAR2B(6)	1992584	31	23	31	10	7	13	1	7	3	0	0.29	1.00	1.00
173	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(2), CYP11A1(2), CYP11B1(2), CYP11B2(2), CYP17A1(2), CYP21A2(3), HSD11B1(1), HSD11B2(2), HSD3B1(1), HSD3B2(1)	1743048	21	16	21	8	11	5	0	4	1	0	0.45	1.00	1.00
174	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(2), CYP11A1(2), CYP11B1(2), CYP11B2(2), CYP17A1(2), CYP21A2(3), HSD11B1(1), HSD11B2(2), HSD3B1(1), HSD3B2(1)	1743048	21	16	21	8	11	5	0	4	1	0	0.45	1.00	1.00
175	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(4), BAIAP2(3), CASP1(2), CASP3(1), CASP7(2), CASP8(6), GAPDH(1), INSR(10), ITCH(3), MAGI1(16), MAGI2(10), RERE(17), WWP1(8), WWP2(10)	4728947	93	42	92	26	26	21	5	19	22	0	0.16	1.00	1.00
176	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(10), PTK2B(8)	1334888	19	16	18	9	11	3	0	4	1	0	0.77	1.00	1.00
177	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(7), CHAT(1), CHKA(1), PCYT1A(7), PDHA1(1), PDHA2(4), PEMT(1), SLC18A3(6)	1368800	28	19	28	11	14	6	0	8	0	0	0.44	1.00	1.00
178	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(2), BFAR(1), BRAF(5), CAMP(1), CREB1(4), CREB3(3), CREB5(2), MAPK1(2), RAF1(6), SNX13(6), TERF2IP(3)	2246021	35	26	35	10	13	9	0	8	5	0	0.36	1.00	1.00
179	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(20), ASAH1(2), CAMP(1), CASP3(1), CERK(3), CREB1(4), CREB3(3), CREB5(2), CXCL2(1), DAG1(7), EPHB2(11), GNAQ(1), ITPKA(1), ITPKB(6), JUN(2), MAP2K4(5), MAP2K7(13), MAPK1(2), MAPK10(3), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3)	5599881	106	40	102	29	33	27	1	22	21	2	0.091	1.00	1.00
180	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(3), CD8A(2), CSF3(1), IL11(2), IL2(1), IL3(1), IL6(1), IL8(1)	1209585	12	11	12	6	3	4	0	4	1	0	0.79	1.00	1.00
181	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(5), FADS2(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3)	2012502	32	22	32	10	14	5	1	10	2	0	0.40	1.00	1.00
182	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADH(2), HADHA(2), HADHB(2), HSD17B4(2), MECR(3), PPT2(2)	1679667	14	8	13	4	1	5	1	3	4	0	0.33	1.00	1.00
183	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAA2(1), ACAD8(2), ACAD9(2), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), AKR1B10(1), AKR1C4(3), AKR1D1(2), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), BAAT(1), CEL(6), CYP27A1(1), CYP7A1(3), HADHB(2), HSD3B7(3), LIPA(2), RDH11(1), RDH12(1), SLC27A5(6), SOAT1(5), SOAT2(2), SRD5A1(2), SRD5A2(3)	6270702	97	44	96	26	21	33	2	28	13	0	0.065	1.00	1.00
184	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP2(3), ACP5(2), ACPP(3), ACPT(1), ENPP1(1), ENPP3(3), FLAD1(2), RFK(1), TYR(5)	1897954	21	16	21	7	4	8	1	5	3	0	0.48	1.00	1.00
185	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(4), ABP1(6), ACADL(2), ACADM(1), ACADSB(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), AOC2(4), AOC3(3), CNDP1(1), DPYD(13), DPYS(2), EHHADH(2), GAD1(3), GAD2(4), HADHA(2), MLYCD(3), SDS(1), SMS(2), UPB1(2)	5752530	90	42	88	27	23	31	2	23	10	1	0.11	1.00	1.00
186	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(8), EIF2AK4(5), EIF2B5(4), EIF2S1(1), EIF2S2(2), EIF2S3(1), EIF5(3), GSK3B(2), PPP1CA(2)	2288962	28	21	28	9	5	12	1	9	1	0	0.41	1.00	1.00
187	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(11), CREM(1), FHL5(1), FSHB(2), FSHR(17), GNAS(14), XPO1(3)	1892432	49	29	46	14	17	13	2	14	3	0	0.44	1.00	1.00
188	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(2), CDK5R1(1), CSNK1D(2), DRD1(3), DRD2(6), GRM1(17), PLCB1(12), PPP1CA(2), PPP2CA(3), PPP3CA(3), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6)	3166545	66	36	66	22	21	24	0	15	6	0	0.26	1.00	1.00
189	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDK2(2), CUL1(10), NEDD8(1), RB1(8), SKP2(4), TFDP1(2)	1709248	30	19	29	11	5	11	1	8	5	0	0.51	1.00	1.00
190	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(4), FUT1(2), FUT9(3), HEXA(1), HEXB(3), NAGA(3), ST3GAL1(3), ST3GAL2(4), ST3GAL4(3), ST8SIA1(4)	2003353	30	24	30	10	12	5	0	12	1	0	0.48	1.00	1.00
191	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CALM2(2), CALM3(1), CDKN1A(1), GNAQ(1), MARCKS(2), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), PLCG1(10), PPP3CA(3), PPP3CB(1), SP1(3), SP3(3)	4113345	59	32	57	17	20	24	0	8	7	0	0.10	1.00	1.00
192	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(3), GALNT10(3), GALNT2(3), GALNT3(1), GALNT4(1), GALNT6(2), GALNT8(5), GALNT9(3), GCNT1(1), ST3GAL1(3), ST3GAL2(4), ST3GAL4(3), WBSCR17(14)	2853308	46	30	44	12	20	10	4	9	3	0	0.16	1.00	1.00
193	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3E(3), CD3G(2), ETV5(5), IFNG(2), IL12B(2), IL12RB1(4), IL12RB2(5), IL18R1(2), JAK2(8), JUN(2), MAP2K6(2), MAPK14(1), MAPK8(4), STAT4(4), TYK2(6)	3674289	53	27	52	15	9	19	3	12	10	0	0.23	1.00	1.00
194	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(9), AMT(4), ATIC(5), GART(6), MTHFD1(3), MTHFD1L(2), MTHFD2(1), MTHFR(5), MTR(9), SHMT1(1), SHMT2(4), TYMS(1)	3544578	50	31	50	15	13	16	4	8	9	0	0.17	1.00	1.00
195	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(4), ABP1(6), ACADM(1), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), AOC2(4), AOC3(3), CNDP1(1), DPYD(13), DPYS(2), EHHADH(2), GAD1(3), GAD2(4), HADHA(2), MLYCD(3), SMS(2), SRM(1), UPB1(2)	5342259	77	39	75	23	21	25	2	20	8	1	0.11	1.00	1.00
196	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(3), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), CYP2C19(6), CYP2C9(1), DHRS3(1), DHRS7(1), DHRSX(2), EHHADH(2), ESCO2(2), HADHA(2), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), SH3GLB1(1), YOD1(2)	6119325	77	37	76	21	20	23	3	22	9	0	0.089	1.00	1.00
197	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(1), SRP19(1), SRP54(2), SRP72(4), SRPR(3)	1491187	12	10	12	5	4	5	0	2	1	0	0.74	1.00	1.00
198	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(5), IFNB1(2), JAK1(4), PTPRU(13), REG1A(4), STAT1(6), STAT2(4), TYK2(6)	2463540	44	26	44	13	17	11	0	11	4	1	0.30	1.00	1.00
199	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(4), ASNS(4), ASRGL1(1), CA1(1), CA12(2), CA13(2), CA14(1), CA2(1), CA3(1), CA4(2), CA5B(1), CA6(3), CA7(2), CA8(1), CA9(2), CPS1(15), CTH(2), GLS(4), GLS2(5), GLUD1(4), GLUD2(7), GLUL(2), HAL(2)	4197941	69	38	69	20	20	18	4	21	6	0	0.19	1.00	1.00
200	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(3), ACAT2(3), BDH1(1), HMGCL(1), HMGCS1(1), HMGCS2(1), OXCT1(4)	1429775	14	12	14	8	4	6	0	3	1	0	0.87	1.00	1.00
201	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ACAA2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), AKR1C4(3), AKR1D1(2), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), BAAT(1), CEL(6), CYP27A1(1), CYP7A1(3), HADHB(2), SOAT2(2), SRD5A1(2), SRD5A2(3)	4596996	81	39	80	25	17	27	0	24	13	0	0.24	1.00	1.00
202	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(4), ADORA2B(1), ADORA3(2), LTB4R(2), P2RY1(5), P2RY2(1), P2RY6(3)	1172555	18	15	18	9	7	4	0	6	1	0	0.74	1.00	1.00
203	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(4), CARS2(2), CTH(2), GOT1(2), GOT2(3), LDHAL6B(2), LDHB(2), LDHC(1), MPST(1), SDS(1), SULT1B1(2), SULT1C4(1), SULT4A1(1)	2456977	24	16	24	8	8	9	1	3	3	0	0.36	1.00	1.00
204	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(1), JUN(2), MAP2K1(4), MAPK1(2), MAPK3(1), NFKB1(5), PLCB1(12), RAF1(6), RELA(2), TNF(2)	3075622	37	24	37	12	10	10	1	11	5	0	0.44	1.00	1.00
205	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(3), GNAQ(1), GNB1(1), GNGT1(3), HTR2C(3), PLCB1(12), TUB(6)	1415903	29	20	29	10	12	7	0	5	5	0	0.48	1.00	1.00
206	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(1), AKT1(2), AKT2(2), AKT3(3), APAF1(2), ATM(17), BAD(1), BCL2(1), BID(1), BIRC2(2), BIRC3(4), CAPN1(3), CAPN2(4), CASP10(3), CASP3(1), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CSF2RB(7), CYCS(1), DFFA(2), DFFB(2), ENDOG(1), FAS(3), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(3), IL3(1), IL3RA(4), IRAK1(5), IRAK2(4), IRAK3(2), IRAK4(3), MAP3K14(3), MYD88(2), NFKB1(5), NFKB2(3), NTRK1(4), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RELA(2), TNF(2), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(2), TNFRSF10D(2), TNFRSF1A(3), TNFSF10(2), TP53(67), TRAF2(2)	16539850	301	101	264	72	89	100	11	55	44	2	0.00021	1.00	1.00
207	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(4), B3GAT2(1), B3GAT3(2), B4GALT7(1), CHPF(2), CHST11(1), CHST12(6), CHST13(1), CHST3(1), CHST7(1), CHSY1(3), DSE(6), UST(5), XYLT1(7), XYLT2(4)	2700217	45	25	45	12	20	15	2	6	2	0	0.093	1.00	1.00
208	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(6), ACY3(1), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH3B2(4), ALDH9A1(4), AOC2(4), AOC3(3), CARM1(2), CNDP1(1), DDC(3), HAL(2), HARS(4), HARS2(3), HDC(5), HNMT(1), LCMT1(1), LCMT2(7), MAOA(1), MAOB(3), METTL6(1), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), PRPS1(1), PRPS2(3), UROC1(4), WBSCR22(2)	7831637	100	45	99	27	22	29	4	34	10	1	0.067	1.00	1.00
209	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(3), CLOCK(2), CRY1(1), CRY2(2), CSNK1E(6), PER1(4)	1667690	18	12	18	7	5	5	1	5	2	0	0.70	1.00	1.00
210	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS3(1), DHRS7(1), DHRSX(2), ESCO2(2), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), SH3GLB1(1)	3281044	37	26	37	11	11	12	3	8	3	0	0.24	1.00	1.00
211	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(5), EGFR(10), ERBB3(21), NRG1(9)	2021890	45	25	42	15	13	12	1	15	4	0	0.44	1.00	1.00
212	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(16), C5(9), C6(8), C7(2), ICAM1(2), IL6(1), IL8(1), ITGA4(8), ITGAL(7), ITGB1(4), ITGB2(6), SELP(2), SELPLG(6), TNF(2), VCAM1(5)	4933886	79	39	78	24	25	19	2	25	8	0	0.15	1.00	1.00
213	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(9), AMT(4), ATIC(5), GART(6), MTHFD1(3), MTHFD1L(2), MTHFD2(1), MTHFR(5), MTR(9), SHMT1(1), SHMT2(4), TYMS(1)	3743352	50	31	50	16	13	16	4	8	9	0	0.23	1.00	1.00
214	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(5), AGT(2), AGTR1(1), AGTR2(1), COL4A1(13), COL4A2(7), COL4A3(4), COL4A4(7), COL4A5(5), COL4A6(7), REN(3)	5039420	55	32	55	19	13	23	1	15	3	0	0.27	1.00	1.00
215	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(8), APOBEC1(3), APOBEC3A(1), APOBEC3B(3), APOBEC3G(2), APOBEC4(1)	1453284	18	14	18	7	8	3	2	4	1	0	0.64	1.00	1.00
216	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(9), ACSS1(7), ACSS2(3), FH(2), IDH1(1), IDH2(1), MDH1(3), MDH2(1), SUCLA2(3)	2635325	32	21	31	11	10	6	4	7	5	0	0.42	1.00	1.00
217	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), HMOX1(3), IL10(1), IL10RA(2), IL10RB(1), IL6(1), JAK1(4), STAT1(6), STAT3(7), STAT5A(1), TNF(2)	2417612	30	19	30	10	5	15	0	8	1	1	0.36	1.00	1.00
218	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), MDH1(3), ME1(3), PC(6), PDHA1(1), SLC25A1(2)	1829312	17	12	17	8	8	2	3	3	1	0	0.71	1.00	1.00
219	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(1), CREBBP(13), EP300(15), FYN(5), IL2RG(3), IL7R(3), JAK1(4), JAK3(3), LCK(1), NMI(1), PIK3CA(33), PIK3R1(7), PTK2B(8), STAT5A(1), STAT5B(4)	5532650	102	48	87	29	19	41	4	18	19	1	0.13	1.00	1.00
220	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK1(6), HK2(6), HK3(3), IMPA1(3), PGM1(3), PGM3(6), TGDS(2)	2022812	32	19	32	11	13	13	3	1	2	0	0.22	1.00	1.00
221	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(3), CYB5R3(1), GCK(3), GFPT1(3), GNE(3), GNPDA1(3), GNPDA2(1), HEXA(1), HEXB(3), HK1(6), HK2(6), HK3(3), PGM3(6), RENBP(2)	3346301	44	26	44	12	20	12	4	6	2	0	0.11	1.00	1.00
222	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(5), GUSB(3), UCHL1(2), UCHL3(3), UGDH(4), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2B15(1), UGT2B4(2)	3479638	25	16	25	9	7	11	0	3	4	0	0.46	1.00	1.00
223	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(4), ARG1(2), ASL(5), CKB(1), CKMT1A(2), CKMT1B(3), CKMT2(6), CPS1(15), GATM(2), GLUD1(4), NAGS(1), ODC1(3), OTC(2), PYCR1(2), SMS(2)	3449399	54	31	54	16	23	13	3	14	1	0	0.19	1.00	1.00
224	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRA2A(2), ADRA2C(3), ADRB1(3), ADRB2(4), ADRB3(1), CHRM1(3), CHRM2(7), CHRM3(6), CHRM4(2), CHRM5(3), DRD1(3), DRD2(6), DRD3(8), DRD4(1), DRD5(10), HRH1(3), HRH2(4), HTR1A(6), HTR1B(5), HTR1D(4), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(5), HTR2C(3), HTR4(4), HTR5A(4), HTR6(1), HTR7(4)	5062052	125	44	121	38	51	32	7	27	8	0	0.025	1.00	1.00
225	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(15), ACACB(13), FASN(11), MCAT(1), OXSM(3)	3095404	43	21	42	13	14	11	1	7	10	0	0.26	1.00	1.00
226	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(8), AP2A1(1), AP2M1(7), CALM1(1), CALM2(2), CALM3(1), DNM1(5), EPN1(4), PICALM(1), PPP3CA(3), PPP3CB(1), SYNJ1(7), SYNJ2(15)	4276223	56	28	52	16	22	9	2	15	8	0	0.23	1.00	1.00
227	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(3), GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(2), HDAC3(4), NCOA1(11), NCOA2(12), NCOA3(7), NCOR2(15), POLR2A(9), RARA(2), RXRA(3), TBP(3)	4922630	79	39	79	27	21	31	2	18	7	0	0.24	1.00	1.00
228	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(3), ACAT2(3), ACOT11(3), ACYP2(1), DHRS3(1), DHRS7(1), DHRSX(2), EHHADH(2), ESCO2(2), FN3K(2), GCDH(3), HADHA(2), ITGB1BP3(3), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), SH3GLB1(1), YOD1(2)	5147020	61	32	60	17	16	25	4	9	7	0	0.069	1.00	1.00
229	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), EIF4E(1), FBL(2), GPT(1), LDHB(2), LDHC(1), MAPK14(1), NCL(7)	1752576	18	13	18	8	6	5	0	6	1	0	0.75	1.00	1.00
230	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG1(2), ASL(5), ASS1(6), CKB(1), CKMT1A(2), CKMT1B(3), CKMT2(6), CPS1(15), DAO(5), EPRS(6), GATM(2), GLUD1(4), GLUD2(7), GOT1(2), GOT2(3), LAP3(1), NOS1(16), NOS3(3), OTC(2), P4HA1(1), P4HA2(6), P4HA3(1), PARS2(1), PYCR1(2), PYCR2(1), PYCRL(1), RARS(2), RARS2(2)	7087433	110	50	109	29	38	29	5	29	9	0	0.052	1.00	1.00
231	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(4), CREM(1), JUN(2), MAPK3(1), OPRK1(4), POLR2A(9), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6)	2541511	36	23	36	13	10	14	0	8	4	0	0.37	1.00	1.00
232	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(4), EPX(4), LPO(2), MPO(5), MTHFR(5), PRDX6(1), SHMT1(1), SHMT2(4), TPO(13)	2297007	40	27	40	13	13	7	3	11	6	0	0.41	1.00	1.00
233	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(2), ARFGAP1(1), ARFGAP3(4), ARFGEF2(14), CLTA(2), COPA(4), GBF1(8), GPLD1(9), KDELR1(1)	3203218	45	26	45	14	13	21	1	9	1	0	0.18	1.00	1.00
234	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(2), BIRC2(2), BIRC3(4), CASP1(2), CASP10(3), CASP2(3), CASP3(1), CASP4(2), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), DFFA(2), DFFB(2), LMNA(5), LMNB1(2), LMNB2(3), PRF1(1)	3811870	45	27	45	12	14	14	4	9	4	0	0.22	1.00	1.00
235	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(1), DHRS3(1), DHRS7(1), DHRSX(2), HSD3B7(3), PON1(1), PON2(2), RDH11(1), RDH12(1)	1780250	13	13	13	9	4	4	1	3	1	0	0.94	1.00	1.00
236	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), BCL2(1), CASP8(6), CYCS(1), MAP2K1(4), MAP2K4(5), MAP3K1(8), MAPK1(2), MAPK3(1), MAPK8(4), NFKB1(5), NSMAF(9), RAF1(6), RELA(2), SMPD1(4), TNFRSF1A(3), TRAF2(2)	4050604	64	29	64	20	20	19	2	13	10	0	0.23	1.00	1.00
237	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSR(4), GSS(1), IL8(1), NFKB1(5), NOX1(4), RELA(2), TNF(2), XDH(9)	1983346	29	18	29	10	5	13	1	7	3	0	0.43	1.00	1.00
238	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(2), AVP(3), CABIN1(8), CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), HDAC5(4), IGF1(2), IGF1R(11), INSR(10), MAP2K6(2), MAPK14(1), MAPK7(8), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), MYOD1(3), NFATC1(9), NFATC2(8), PIK3CA(33), PIK3R1(7), PPP3CA(3), PPP3CB(1), YWHAH(1)	6848276	136	53	122	36	42	57	5	21	11	0	0.0031	1.00	1.00
239	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(3), GPLD1(9), PGAP1(4), PIGA(2), PIGB(4), PIGC(2), PIGG(5), PIGK(1), PIGL(1), PIGM(4), PIGN(3), PIGO(1), PIGQ(2), PIGS(1), PIGT(3), PIGV(3), PIGX(2), PIGZ(2)	4747955	52	28	52	16	16	21	3	6	5	1	0.12	1.00	1.00
240	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2G(4), CAMK4(4), CAMKK1(4), CAMKK2(1), CREB1(4)	2277358	28	17	28	10	7	12	1	5	3	0	0.45	1.00	1.00
241	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(2), CCND1(1), CCNE1(3), CDK2(2), CDK6(4), CDKN1A(1), MAPK1(2), MAPK3(1), NFKB1(5), PAK1(4), PIK3CA(33), PIK3R1(7), RAF1(6), RB1(8), RELA(2), TFDP1(2)	4012864	83	44	68	25	13	39	4	16	11	0	0.19	1.00	1.00
242	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(2), BIRC2(2), BIRC3(4), CASP10(3), CASP3(1), CASP7(2), CASP8(6), CASP9(1), DFFA(2), DFFB(2), PRF1(1), SCAP(7), SREBF1(4), SREBF2(7)	3572783	44	30	44	13	13	14	3	9	5	0	0.33	1.00	1.00
243	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(4), ASNS(4), CA1(1), CA12(2), CA14(1), CA2(1), CA3(1), CA4(2), CA5B(1), CA6(3), CA7(2), CA8(1), CA9(2), CPS1(15), CTH(2), GLS(4), GLS2(5), GLUD1(4), GLUL(2), HAL(2)	3755719	59	33	59	19	15	17	4	17	6	0	0.34	1.00	1.00
244	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(4), JAK2(8), JAK3(3), PIAS1(3), PIAS3(1), PTPRU(13), REG1A(4), SOAT1(5)	2726935	43	25	43	13	13	11	0	12	6	1	0.44	1.00	1.00
245	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(3), CLOCK(2), CRY1(1), CRY2(2), CSNK1D(2), CSNK1E(6), NPAS2(5), NR1D1(3), PER1(4), PER2(10), PER3(7)	3357480	45	22	45	14	13	14	3	10	5	0	0.30	1.00	1.00
246	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDPS(4), HMGCR(5), LSS(5), MVD(2), MVK(4), NQO1(3), NQO2(3), SC5DL(1), SQLE(4), VKORC1(1)	2191139	34	21	34	12	13	9	1	9	2	0	0.45	1.00	1.00
247	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(2), ESR1(5), GREB1(12), HSPB1(1), HSPB2(1), MTA1(6), PDZK1(2), TUBA8(3)	2159489	32	22	32	13	10	12	1	4	5	0	0.54	1.00	1.00
248	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(2), DLG4(5), EPHB2(11), F2(4), F2RL1(3), F2RL2(1), JUN(2), MAP2K5(1), MAPK1(2), MAPK7(8), MAPK8(4), MYEF2(4), PLD1(7), PLD2(11), PLD3(5), PTK2(7), RAF1(6), RASAL1(1), TEC(3), VAV1(7)	5409910	94	40	91	28	28	31	4	19	12	0	0.16	1.00	1.00
249	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(2), ATM(17), ATR(5), BAI1(7), BID(1), CASP3(1), CASP8(6), CASP9(1), CCNB1(1), CCNB2(1), CCNB3(7), CCND1(1), CCND2(1), CCND3(2), CCNE1(3), CCNE2(1), CCNG2(1), CD82(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(4), CHEK1(2), CHEK2(5), CYCS(1), DDB2(2), EI24(1), FAS(3), GTSE1(4), IGF1(2), IGFBP3(4), LRDD(4), MDM2(3), MDM4(3), PERP(2), PPM1D(4), PTEN(8), RFWD2(5), RPRM(3), RRM2(2), RRM2B(2), SERPINB5(3), SERPINE1(2), SESN1(1), SESN2(1), SESN3(2), SIAH1(1), STEAP3(5), THBS1(9), TNFRSF10B(2), TP53(67), TP73(5), TSC2(4), ZMAT3(2)	12906690	235	96	215	62	72	68	7	43	43	2	0.0088	1.00	1.00
250	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	IFNG(2), IKBKB(3), IL2(1), JUN(2), MAP3K1(8), MAP3K5(3), MAP4K5(4), MAPK14(1), MAPK8(4), NFKB1(5), RELA(2), TNFRSF9(3), TRAF2(2)	3858434	40	21	39	12	15	7	2	10	6	0	0.37	1.00	1.00
251	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(6), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH3B2(4), ALDH9A1(4), AOC2(4), AOC3(3), CNDP1(1), DDC(3), HAL(2), HARS(4), HDC(5), HNMT(1), MAOA(1), MAOB(3), PRPS1(1), PRPS2(3)	4839432	73	38	72	24	17	20	3	26	6	1	0.33	1.00	1.00
252	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2E2(2), GTF2F1(2), GTF2F2(2), GTF2H1(1), GTF2H3(1), GTF2I(4), GTF2IRD1(9), TAF1(5), TAF10(1), TAF13(1), TAF1L(11), TAF2(5), TAF4(3), TAF4B(2), TAF5(2), TAF5L(4), TAF6(7), TAF6L(1), TAF7(4), TAF7L(3), TAF9B(2), TBPL2(3)	7152812	83	38	80	23	26	28	3	16	10	0	0.094	1.00	1.00
253	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(5), IFNAR2(4), IFNB1(2), JAK1(4), STAT1(6), STAT2(4), TYK2(6)	2143249	32	18	32	11	9	11	0	7	4	1	0.47	1.00	1.00
254	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(4), ELK1(2), EPOR(2), GRB2(1), JAK2(8), JUN(2), MAP2K1(4), MAPK3(1), MAPK8(4), PLCG1(10), PTPN6(3), RAF1(6), SHC1(3), SOS1(4), STAT5A(1), STAT5B(4)	4249380	59	28	58	18	15	23	1	13	7	0	0.27	1.00	1.00
255	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(3), PSMA6(3), PSMA7(3), PSMB2(1), PSMB3(1), PSMB4(1), PSMC2(3), PSMC3(6), PSMD1(4), PSMD11(1), PSMD12(1), PSMD2(10), PSMD6(1)	3157005	41	21	41	11	12	15	2	9	3	0	0.23	1.00	1.00
256	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(3), G6PD(2), GCLM(2), GGT1(8), GPX1(1), GPX3(1), GPX4(3), GPX6(2), GPX7(3), GSR(4), GSS(1), GSTA1(2), GSTA2(1), GSTA4(1), GSTA5(1), GSTM1(1), GSTM3(1), GSTM4(1), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(3), IDH1(1), IDH2(1), MGST1(2), MGST2(1), MGST3(1), OPLAH(5), TXNDC12(1)	4295304	58	30	57	19	20	17	2	16	3	0	0.28	1.00	1.00
257	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(4), ANKRD1(2), DUSP14(1), EIF4E(1), EIF4EBP1(1), IFNG(2), IFRD1(2), IL1R1(3), NR4A3(1), WDR1(1)	2117610	18	12	18	9	5	4	4	4	1	0	0.77	1.00	1.00
258	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(2), ABP1(6), AOC2(4), AOC3(3), CES1(7), CES7(7), DDHD1(7), ESCO2(2), LIPA(2), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), PRDX6(1), SH3GLB1(1)	5032944	72	35	71	22	20	26	4	18	3	1	0.18	1.00	1.00
259	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	COPS5(3), CREB1(4), EDN1(3), EP300(15), HIF1A(2), JUN(2), NOS3(3), P4HB(4)	3351533	36	23	36	12	11	10	2	7	6	0	0.38	1.00	1.00
260	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(7), CHAT(1), COMT(3), DBH(2), DDC(3), GAD1(3), GAD2(4), HDC(5), MAOA(1), PAH(5), PNMT(3), SLC18A3(6), TH(1), TPH1(1)	2830261	46	26	46	18	17	13	2	12	2	0	0.43	1.00	1.00
261	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(9), DLD(2), DLST(1), FH(2), IDH1(1), IDH2(1), IDH3A(1), IDH3B(3), IDH3G(2), MDH1(3), MDH2(1), PC(6), PCK1(4), SDHA(5), SDHB(4), SUCLA2(3), SUCLG1(2), SUCLG2(4)	4068735	54	29	53	18	23	11	2	13	5	0	0.29	1.00	1.00
262	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(13), DUSP1(1), EP300(15), IKBKB(3), IL1B(1), IL8(1), MAP2K3(1), MAP2K6(2), MAP3K14(3), MAP3K7(7), MAPK11(1), MAPK14(1), MYD88(2), NFKB1(5), NR3C1(5), RELA(2), TGFBR1(2), TGFBR2(6), TLR2(3), TNF(2)	5856775	76	38	76	24	16	23	4	18	15	0	0.36	1.00	1.00
263	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNA1(1), IFNB1(2), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(3), IL6(1), IRAK1(5), IRAK2(4), IRAK3(2), JUN(2), MAP2K3(1), MAP2K6(2), MAP3K1(8), MAP3K14(3), MAP3K7(7), MAPK14(1), MAPK8(4), MYD88(2), NFKB1(5), RELA(2), TGFB1(3), TGFB2(6), TGFB3(4), TNF(2), TOLLIP(1), TRAF6(4)	5857347	82	38	81	25	21	23	4	25	9	0	0.31	1.00	1.00
264	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(10), ABCB11(6), ABCB4(13), ABCC1(4), ABCC3(6), GSTP1(1)	2848513	40	25	40	15	10	15	1	8	6	0	0.50	1.00	1.00
265	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(5), AGT(2), AGTR2(1), EDN1(3), EDNRA(3), EDNRB(13), EGF(5), EGFR(10), JUN(2), NFKB1(5), PLCG1(10), RELA(2)	4079402	61	28	59	22	20	13	2	18	8	0	0.44	1.00	1.00
266	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(4), ELK1(2), GRB2(1), JAK1(4), JUN(2), MAP2K1(4), MAP2K4(5), MAP3K1(8), MAPK3(1), MAPK8(4), PDGFA(1), PDGFRA(4), PIK3CA(33), PIK3R1(7), PLCG1(10), RAF1(6), RASA1(10), SHC1(3), SOS1(4), SRF(1), STAT1(6), STAT3(7), STAT5A(1)	6918924	128	53	112	32	31	55	5	19	16	2	0.0099	1.00	1.00
267	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(1), AGTR2(1), ATP8A1(7), AVPR1A(7), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(3), C3AR1(2), CCKAR(2), CCKBR(4), CCR1(2), CCR10(2), CCR2(3), CCR3(4), CCR5(1), CCR6(1), CCR8(2), CX3CR1(4), CXCR4(2), CXCR6(1), EDNRA(3), EDNRB(13), FPR1(1), FSHR(17), GALR1(3), GALR2(1), GALR3(1), GALT(1), GHSR(4), GNRHR(3), GRPR(3), LHCGR(7), MC2R(2), MC3R(3), MC4R(4), MC5R(6), NMBR(1), NPY1R(2), NPY2R(1), NPY5R(1), NTSR1(4), OPRD1(3), OPRK1(4), OPRL1(2), OXTR(4), PPYR1(7), SSTR1(10), SSTR2(2), SSTR3(4), SSTR4(8), TAC4(1), TACR1(3), TACR2(2), TACR3(6), TRHR(6), TSHR(8)	10300069	203	67	198	61	72	71	4	41	15	0	0.0030	1.00	1.00
268	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(2), ARPC1A(3), ARPC1B(1), ARPC4(1), CDC42(1), PAK1(4), PDGFRA(4), PIK3CA(33), PIK3R1(7), WASL(1)	2658487	57	38	43	18	11	31	4	5	6	0	0.23	1.00	1.00
269	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(8), CALM1(1), CALM2(2), CALM3(1), CAPN2(4), CAPNS1(1), CAPNS2(1), EP300(15), HDAC1(2), HDAC2(4), MEF2D(6), NFATC1(9), NFATC2(8), PPP3CA(3), PPP3CB(1)	4814967	66	27	66	20	24	21	0	12	9	0	0.13	1.00	1.00
270	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(3), CHIA(2), CHIT1(2), CMAS(3), CTBS(2), CYB5R1(1), CYB5R3(1), GFPT1(3), GFPT2(3), GNE(3), GNPDA1(3), GNPDA2(1), HEXA(1), HEXB(3), HK1(6), HK2(6), HK3(3), LHPP(3), MTMR1(3), MTMR2(3), MTMR6(4), NAGK(1), NANS(1), NPL(1), PGM3(6), PHPT1(3), RENBP(2)	5660317	73	33	73	23	28	24	5	14	2	0	0.14	1.00	1.00
271	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM2(2), CALM3(1), DLG4(5), GRIN1(4), GRIN2A(7), GRIN2B(13), GRIN2C(4), GRIN2D(1), NOS1(16), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6)	5038985	73	36	73	27	26	26	1	12	8	0	0.38	1.00	1.00
272	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(3), DHCR7(2), FDPS(4), HMGCR(5), HMGCS1(1), LSS(5), MVD(2), MVK(4), NSDHL(3), SC4MOL(2), SC5DL(1), SQLE(4)	2612233	36	20	36	13	13	8	2	11	2	0	0.53	1.00	1.00
273	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(4), ACACA(15), ACADL(2), ACADM(1), ACADSB(3), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH6A1(1), ALDH9A1(4), EHHADH(2), HADHA(2), LDHB(2), LDHC(1), MCEE(3), MLYCD(3), MUT(3), PCCA(7), PCCB(2), SDS(1), SUCLA2(3), SUCLG1(2), SUCLG2(4)	6540273	99	37	95	29	26	32	0	21	20	0	0.17	1.00	1.00
274	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(2), APC(20), AXIN1(7), CCND1(1), CD14(1), CTNNB1(11), DVL1(4), FZD1(8), GJA1(8), GNAI1(1), GSK3B(2), IRAK1(5), LEF1(4), LY96(1), MYD88(2), NFKB1(5), PDPK1(1), PIK3CA(33), PIK3R1(7), PPP2CA(3), RELA(2), TIRAP(2), TLR4(13), TOLLIP(1), WNT1(3)	6057735	147	69	129	40	30	50	11	34	20	2	0.037	1.00	1.00
275	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(1), CALM2(2), CALM3(1), CD3E(3), CD3G(2), ELK1(2), FYN(5), GRB2(1), JUN(2), LCK(1), MAP2K1(4), MAP2K4(5), MAP3K1(8), MAPK3(1), MAPK8(4), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NFKB1(5), PIK3CA(33), PIK3R1(7), PLCG1(10), PPP3CA(3), PPP3CB(1), PTPN7(2), RAF1(6), RASA1(10), RELA(2), SHC1(3), SOS1(4), VAV1(7), ZAP70(4)	9436958	170	59	153	41	42	66	6	28	27	1	0.0031	1.00	1.00
276	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPAT6(2), AGPS(3), CHPT1(1), ENPP2(3), ENPP6(2), PAFAH1B1(3), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLD1(7), PLD2(11), PPAP2C(5)	4600941	70	31	70	23	21	25	3	13	8	0	0.24	1.00	1.00
277	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREB1(4), CREBBP(13), EP300(15), NCOA3(7), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RARA(2), RXRA(3)	4082329	61	32	61	22	14	24	2	8	13	0	0.35	1.00	1.00
278	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(5), ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), FPGT(3), GCK(3), GMDS(2), GMPPA(4), HK1(6), HK2(6), HK3(3), PFKFB3(2), PFKFB4(1), PFKM(3), PFKP(8), PMM1(1), PMM2(1), TPI1(2)	4749720	61	27	61	20	30	17	2	9	3	0	0.15	1.00	1.00
279	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(6), ALDH1A3(6), ALDH3A1(5), ALDH3B2(4), AOC2(4), AOC3(3), DDC(3), EPX(4), GOT1(2), GOT2(3), HPD(1), LPO(2), MAOA(1), MAOB(3), MPO(5), PRDX6(1), TAT(1), TPO(13)	4342043	67	36	67	23	19	16	1	24	6	1	0.44	1.00	1.00
280	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(13), COL4A2(7), COL4A3(4), COL4A4(7), COL4A5(5), COL4A6(7), P4HB(4), SLC23A1(6), SLC23A2(7), SLC2A1(3), SLC2A3(2)	5002789	65	30	65	28	18	25	0	15	7	0	0.58	1.00	1.00
281	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(2), AKT2(2), AKT3(3), BPNT1(2), GRB2(1), ILK(2), MAPK1(2), MAPK3(1), PDK1(1), PIK3CA(33), PIK3CD(8), PTEN(8), PTK2B(8), RBL2(1), SHC1(3), SOS1(4)	4043997	81	46	66	23	23	36	3	11	8	0	0.13	1.00	1.00
282	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(4), EGF(5), EGFR(10), ELK1(2), GRB2(1), JAK1(4), JUN(2), MAP2K1(4), MAP2K4(5), MAP3K1(8), MAPK3(1), MAPK8(4), PIK3CA(33), PIK3R1(7), PLCG1(10), RAF1(6), RASA1(10), SHC1(3), SOS1(4), SRF(1), STAT1(6), STAT3(7), STAT5A(1)	7430699	138	56	122	35	32	56	5	24	19	2	0.012	1.00	1.00
283	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(2), BAD(1), CHRNG(3), MUSK(5), PIK3CA(33), PIK3R1(7), PTK2(7), PTK2B(8), RAPSN(2), TERT(3), YWHAH(1)	3227060	72	42	58	25	16	31	6	11	8	0	0.31	1.00	1.00
284	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(7), ACVR1C(3), AKT1(2), AKT2(2), AKT3(3), ARRB1(3), ARRB2(3), ATF4(1), BDNF(1), BRAF(5), CACNA1A(11), CACNA1B(14), CACNA1C(23), CACNA1D(15), CACNA1E(26), CACNA1F(2), CACNA1G(11), CACNA1H(11), CACNA1I(14), CACNA1S(10), CACNA2D1(6), CACNA2D2(5), CACNA2D3(6), CACNA2D4(9), CACNB1(1), CACNB2(10), CACNB4(3), CACNG2(1), CACNG3(3), CACNG4(3), CACNG5(3), CACNG6(1), CACNG7(5), CASP3(1), CD14(1), CDC25B(4), CDC42(1), CRK(1), DAXX(3), DDIT3(3), DUSP1(1), DUSP10(3), DUSP14(1), DUSP16(3), DUSP2(2), DUSP4(1), DUSP5(3), DUSP6(1), DUSP8(1), DUSP9(2), ECSIT(1), EGF(5), EGFR(10), ELK1(2), ELK4(4), FAS(3), FGF1(2), FGF10(4), FGF11(1), FGF12(4), FGF13(4), FGF14(4), FGF17(2), FGF18(2), FGF2(2), FGF20(1), FGF21(1), FGF22(4), FGF23(1), FGF5(1), FGF6(5), FGF7(1), FGF9(5), FGFR1(8), FGFR2(5), FGFR3(1), FGFR4(6), FLNA(11), FLNB(6), FLNC(21), GNA12(1), GNG12(1), GRB2(1), IKBKB(3), IL1B(1), IL1R1(3), IL1R2(1), JUN(2), KRAS(17), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K5(1), MAP2K6(2), MAP2K7(13), MAP3K1(8), MAP3K10(6), MAP3K12(4), MAP3K13(5), MAP3K14(3), MAP3K2(2), MAP3K3(2), MAP3K4(10), MAP3K5(3), MAP3K6(5), MAP3K7(7), MAP3K8(1), MAP4K1(2), MAP4K2(4), MAP4K3(2), MAP4K4(5), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(8), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3), MAPKAPK3(3), MAPKAPK5(2), MAPT(4), MAX(1), MEF2C(2), MKNK1(1), MOS(3), NF1(14), NFATC2(8), NFATC4(11), NFKB1(5), NFKB2(3), NLK(5), NR4A1(2), NRAS(1), NTF3(2), NTRK1(4), NTRK2(5), PAK1(4), PAK2(5), PDGFA(1), PDGFB(3), PDGFRA(4), PDGFRB(8), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PPM1A(3), PPM1B(8), PPP3CA(3), PPP3CB(1), PPP3R2(1), PPP5C(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), PTPN5(1), PTPN7(2), PTPRR(4), RAC2(1), RAC3(1), RAF1(6), RAP1A(2), RAP1B(4), RAPGEF2(9), RASA1(10), RASA2(7), RASGRF1(6), RASGRF2(10), RASGRP1(4), RASGRP2(4), RASGRP3(2), RASGRP4(3), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA4(2), RPS6KA6(7), RRAS(3), RRAS2(1), SOS1(4), SOS2(5), SRF(1), STK3(3), STK4(3), STMN1(2), TAOK1(6), TAOK2(8), TAOK3(5), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6), TNF(2), TNFRSF1A(3), TP53(67), TRAF2(2), TRAF6(4), ZAK(3)	56534466	938	118	898	289	320	290	30	176	118	4	0.000024	1.00	1.00
285	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	235	ADCYAP1R1(6), ADORA1(4), ADORA2B(1), ADORA3(2), ADRA1A(7), ADRA1B(3), ADRA2A(2), ADRA2B(2), ADRA2C(3), ADRB1(3), ADRB2(4), ADRB3(1), AGTR1(1), AGTR2(1), AVPR1A(7), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(3), C3AR1(2), C5AR1(1), CALCR(4), CALCRL(5), CCKAR(2), CCKBR(4), CHRM1(3), CHRM2(7), CHRM3(6), CHRM4(2), CHRM5(3), CNR1(5), CRHR1(2), CRHR2(3), CTSG(3), CYSLTR1(2), DRD1(3), DRD2(6), DRD3(8), DRD4(1), DRD5(10), EDNRA(3), EDNRB(13), F2(4), F2R(2), F2RL1(3), F2RL2(1), FPR1(1), FSHB(2), FSHR(17), GABBR1(8), GABBR2(5), GABRA1(5), GABRA2(5), GABRA3(5), GABRA4(4), GABRA5(5), GABRA6(5), GABRB1(2), GABRB2(4), GABRB3(6), GABRE(4), GABRG1(1), GABRG2(9), GABRG3(2), GABRP(4), GABRQ(7), GABRR1(6), GABRR2(5), GALR1(3), GALR2(1), GALR3(1), GH1(3), GH2(3), GHR(5), GHSR(4), GLP1R(1), GLP2R(4), GLRA1(2), GLRA2(1), GLRA3(2), GLRB(5), GNRHR(3), GPR156(2), GPR35(3), GPR50(5), GPR83(5), GRIA1(11), GRIA2(13), GRIA3(6), GRIA4(3), GRID1(15), GRID2(11), GRIK1(6), GRIK2(11), GRIK3(8), GRIK4(8), GRIK5(5), GRIN1(4), GRIN2A(7), GRIN2B(13), GRIN2C(4), GRIN2D(1), GRIN3A(6), GRIN3B(2), GRM1(17), GRM2(11), GRM3(5), GRM4(5), GRM5(14), GRM6(8), GRM7(12), GRM8(11), GRPR(3), GZMA(2), HCRTR1(3), HCRTR2(2), HRH1(3), HRH2(4), HRH3(3), HRH4(1), HTR1A(6), HTR1B(5), HTR1D(4), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(5), HTR2C(3), HTR4(4), HTR5A(4), HTR6(1), HTR7(4), LEPR(8), LHB(1), LHCGR(7), LTB4R(2), LTB4R2(3), MAS1(2), MC2R(2), MC3R(3), MC4R(4), MC5R(6), MCHR1(4), MCHR2(3), MLNR(2), MTNR1A(3), MTNR1B(2), NMBR(1), NMUR1(2), NMUR2(1), NPBWR1(8), NPBWR2(5), NPFFR1(1), NPFFR2(4), NPY1R(2), NPY2R(1), NPY5R(1), NR3C1(5), NTSR1(4), OPRD1(3), OPRK1(4), OPRL1(2), OXTR(4), P2RX1(1), P2RX2(5), P2RX3(2), P2RX4(1), P2RX5(2), P2RY1(5), P2RY10(3), P2RY13(4), P2RY14(2), P2RY2(1), P2RY4(2), P2RY6(3), P2RY8(6), PARD3(8), PPYR1(7), PRL(2), PRLHR(2), PRLR(2), PRSS1(3), PRSS3(2), PTAFR(2), PTGDR(5), PTGER2(2), PTGER3(2), PTGER4(1), PTGFR(3), PTH2R(4), RXFP1(5), RXFP2(6), SCTR(2), SSTR1(10), SSTR2(2), SSTR3(4), SSTR4(8), SSTR5(2), TAAR1(3), TAAR2(2), TAAR5(3), TAAR6(5), TACR1(3), TACR2(2), TACR3(6), TBXA2R(7), THRA(4), THRB(5), TRHR(6), TRPV1(6), TSHB(1), TSHR(8), UTS2R(1), VIPR1(4), VIPR2(4)	43680064	899	116	886	265	323	268	34	215	59	0	1.37e-07	1.00	1.00
286	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(4), ACTG1(2), ACTN1(3), ACTN2(15), ACTN3(2), ACTN4(1), AKT1(2), AKT2(2), AKT3(3), ARHGAP5(6), BAD(1), BCAR1(4), BCL2(1), BIRC2(2), BIRC3(4), BRAF(5), CAPN2(4), CAV1(2), CCND1(1), CCND2(1), CCND3(2), CDC42(1), CHAD(4), COL11A1(15), COL11A2(8), COL1A1(7), COL1A2(17), COL2A1(8), COL3A1(8), COL4A1(13), COL4A2(7), COL4A4(7), COL4A6(7), COL5A1(14), COL5A2(6), COL5A3(5), COL6A1(7), COL6A2(8), COL6A3(21), COL6A6(20), COMP(3), CRK(1), CTNNB1(11), DIAPH1(4), DOCK1(12), EGF(5), EGFR(10), ELK1(2), ERBB2(6), FARP2(4), FLNA(11), FLNB(6), FLNC(21), FLT1(6), FN1(21), FYN(5), GRB2(1), GRLF1(8), GSK3B(2), HGF(11), IBSP(2), IGF1(2), IGF1R(11), ILK(2), ITGA1(4), ITGA10(6), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGA7(5), ITGA8(5), ITGA9(9), ITGAV(4), ITGB1(4), ITGB3(5), ITGB4(12), ITGB5(3), ITGB6(1), ITGB7(3), ITGB8(7), JUN(2), KDR(7), LAMA1(22), LAMA2(18), LAMA3(10), LAMA4(11), LAMA5(14), LAMB1(9), LAMB2(12), LAMB3(13), LAMB4(9), LAMC1(7), LAMC2(8), LAMC3(11), MAP2K1(4), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK9(3), MET(4), MYL2(1), MYL7(1), MYLK(9), MYLK2(3), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PARVA(1), PARVB(3), PARVG(2), PDGFA(1), PDGFB(3), PDGFC(3), PDGFD(3), PDGFRA(4), PDGFRB(8), PDPK1(1), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PIP5K1C(6), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R12A(1), PRKCG(4), PTEN(8), PTK2(7), PXN(2), RAC2(1), RAC3(1), RAF1(6), RAP1A(2), RAP1B(4), RAPGEF1(6), RELN(21), RHOA(8), ROCK1(7), ROCK2(3), SHC1(3), SHC2(2), SHC3(4), SHC4(1), SOS1(4), SOS2(5), SPP1(1), THBS1(9), THBS2(7), THBS3(4), THBS4(4), TLN1(13), TLN2(22), TNC(13), TNN(12), TNR(13), TNXB(26), VASP(3), VAV1(7), VAV2(8), VAV3(6), VCL(2), VEGFC(3), VTN(4), VWF(13), ZYX(2)	73533080	1117	114	1089	466	368	376	34	224	112	3	0.65	1.00	1.00
287	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(20), APC2(6), AXIN1(7), AXIN2(3), BTRC(3), CACYBP(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CCND1(1), CCND2(1), CCND3(2), CER1(3), CHD8(9), CREBBP(13), CSNK1A1L(3), CSNK1E(6), CSNK2A1(4), CSNK2A2(1), CTBP1(2), CTBP2(4), CTNNB1(11), CTNNBIP1(1), CUL1(10), CXXC4(2), DAAM1(8), DAAM2(5), DKK1(5), DKK2(2), DKK4(2), DVL1(4), DVL2(3), DVL3(5), EP300(15), FBXW11(5), FZD1(8), FZD10(8), FZD2(3), FZD3(4), FZD4(2), FZD5(1), FZD6(8), FZD7(2), FZD8(4), GSK3B(2), JUN(2), LEF1(4), LRP5(9), LRP6(3), MAP3K7(7), MAPK10(3), MAPK8(4), MAPK9(3), MMP7(1), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NKD1(6), NKD2(1), NLK(5), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PORCN(3), PPARD(5), PPP2CA(3), PPP2CB(3), PPP2R1A(5), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(3), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRICKLE1(9), PRICKLE2(12), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), PSEN1(1), RAC2(1), RAC3(1), RHOA(8), ROCK1(7), ROCK2(3), RUVBL1(4), SENP2(3), SFRP1(3), SFRP2(2), SFRP4(2), SFRP5(1), SIAH1(1), SMAD2(8), SMAD3(2), SMAD4(9), SOX17(4), TBL1X(2), TBL1XR1(2), TCF7(2), TCF7L1(3), TCF7L2(5), TP53(67), VANGL1(3), WIF1(2), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(5), WNT3A(1), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2)	31876811	590	110	557	177	193	174	18	113	88	4	0.00048	1.00	1.00
288	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(3), ACTN1(3), ACTN2(15), ACTN3(2), ACTN4(1), APC(20), APC2(6), ARAF(6), ARHGEF1(2), ARHGEF12(6), ARHGEF4(4), ARHGEF6(10), ARHGEF7(9), ARPC1A(3), ARPC1B(1), ARPC4(1), BAIAP2(3), BCAR1(4), BDKRB1(1), BDKRB2(3), BRAF(5), CD14(1), CDC42(1), CFL1(1), CHRM1(3), CHRM2(7), CHRM3(6), CHRM4(2), CHRM5(3), CRK(1), CSK(3), CYFIP1(5), CYFIP2(9), DIAPH1(4), DIAPH2(3), DIAPH3(14), DOCK1(12), EGF(5), EGFR(10), F2(4), F2R(2), FGD1(5), FGD3(8), FGF1(2), FGF10(4), FGF11(1), FGF12(4), FGF13(4), FGF14(4), FGF17(2), FGF18(2), FGF2(2), FGF20(1), FGF21(1), FGF22(4), FGF23(1), FGF5(1), FGF6(5), FGF7(1), FGF9(5), FGFR1(8), FGFR2(5), FGFR3(1), FGFR4(6), FN1(21), GIT1(2), GNA12(1), GNG12(1), GRLF1(8), GSN(5), IQGAP1(5), IQGAP2(9), IQGAP3(10), ITGA1(4), ITGA10(6), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGA7(5), ITGA8(5), ITGA9(9), ITGAD(6), ITGAE(4), ITGAL(7), ITGAM(5), ITGAV(4), ITGAX(6), ITGB1(4), ITGB2(6), ITGB3(5), ITGB4(12), ITGB5(3), ITGB6(1), ITGB7(3), ITGB8(7), KRAS(17), LIMK1(4), LIMK2(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MOS(3), MSN(3), MYH10(16), MYH14(11), MYH9(13), MYL2(1), MYL7(1), MYLK(9), MYLK2(3), NCKAP1(6), NCKAP1L(7), NRAS(1), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PDGFA(1), PDGFB(3), PDGFRA(4), PDGFRB(8), PFN2(2), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1C(6), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R12A(1), PPP1R12B(7), PTK2(7), PXN(2), RAC2(1), RAC3(1), RAF1(6), RDX(2), RHOA(8), ROCK1(7), ROCK2(3), RRAS(3), RRAS2(1), SCIN(3), SLC9A1(6), SOS1(4), SOS2(5), SSH1(6), SSH2(13), SSH3(5), TIAM1(15), TIAM2(18), TMSL3(1), VAV1(7), VAV2(8), VAV3(6), VCL(2), WASF1(4), WASF2(2), WASL(1)	54693643	878	110	838	328	293	277	27	177	102	2	0.25	1.00	1.00
289	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(2), ATM(17), BUB1(6), BUB1B(3), BUB3(2), CCNA1(5), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(7), CCND2(1), CCND3(2), CCNE1(3), CCNE2(1), CCNH(2), CDAN1(5), CDC14A(6), CDC20(2), CDC25A(2), CDC25B(4), CDC25C(3), CDC6(2), CDC7(3), CDH1(14), CDK2(2), CDKN1A(1), CDKN2A(4), CHEK1(2), CHEK2(5), DTX4(4), E2F2(2), E2F3(1), E2F5(1), EP300(15), ESPL1(12), GSK3B(2), HDAC1(2), HDAC2(4), HDAC3(4), HDAC4(7), HDAC5(4), HDAC6(3), HDAC8(3), MAD1L1(6), MAD2L2(1), MCM2(9), MCM3(4), MCM4(6), MCM5(8), MCM6(1), MCM7(5), MDM2(3), MPEG1(5), ORC1L(10), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PLK1(5), PRKDC(22), PTPRA(5), RB1(8), RBL1(5), SKP2(4), SMAD4(9), TBC1D8(6), TFDP1(2), TGFB1(3), TP53(67), WEE1(1)	21915068	382	107	359	118	113	99	19	80	69	2	0.074	1.00	1.00
290	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY7(10), ADCY8(12), ADCY9(6), ADORA2B(1), ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRB1(3), ADRB2(4), ADRB3(1), AGTR1(1), ATP2A1(3), ATP2A2(4), ATP2A3(4), ATP2B1(8), ATP2B2(9), ATP2B3(10), ATP2B4(2), AVPR1A(7), AVPR1B(1), BDKRB1(1), BDKRB2(3), CACNA1A(11), CACNA1B(14), CACNA1C(23), CACNA1D(15), CACNA1E(26), CACNA1F(2), CACNA1G(11), CACNA1H(11), CACNA1I(14), CACNA1S(10), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CAMK4(4), CCKAR(2), CCKBR(4), CD38(2), CHRM1(3), CHRM2(7), CHRM3(6), CHRM5(3), CHRNA7(1), CYSLTR1(2), DRD1(3), EDNRA(3), EDNRB(13), EGFR(10), ERBB2(6), ERBB3(21), ERBB4(18), F2R(2), GNA11(4), GNA14(2), GNA15(2), GNAQ(1), GNAS(14), GRIN1(4), GRIN2A(7), GRIN2C(4), GRIN2D(1), GRM1(17), GRM5(14), GRPR(3), HRH1(3), HRH2(4), HTR2A(2), HTR2B(5), HTR2C(3), HTR4(4), HTR5A(4), HTR6(1), HTR7(4), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), LHCGR(7), LTB4R2(3), MYLK(9), MYLK2(3), NOS1(16), NOS3(3), NTSR1(4), OXTR(4), P2RX1(1), P2RX2(5), P2RX3(2), P2RX4(1), P2RX5(2), PDE1A(3), PDE1B(2), PDE1C(3), PDGFRA(4), PDGFRB(8), PHKA1(5), PHKA2(7), PHKB(3), PHKG1(2), PHKG2(3), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLCD1(1), PLCD3(6), PLCE1(9), PLCG1(10), PLCG2(6), PLCZ1(2), PPID(3), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), PTAFR(2), PTGER3(2), PTGFR(3), PTK2B(8), RYR1(33), RYR2(43), RYR3(40), SLC25A4(2), SLC25A5(2), SLC25A6(4), SLC8A1(6), SLC8A2(3), SLC8A3(5), SPHK1(5), TACR1(3), TACR2(2), TACR3(6), TBXA2R(7), TNNC1(3), TNNC2(1), TRHR(6), TRPC1(2), VDAC1(2), VDAC3(1)	53451592	925	107	910	322	355	293	39	159	77	2	0.0014	1.00	1.00
291	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(2), ANAPC1(14), ANAPC11(1), ANAPC2(3), ANAPC4(2), ANAPC5(2), ANAPC7(1), ATM(17), ATR(5), BUB1(6), BUB1B(3), BUB3(2), CCNA1(5), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(7), CCND1(1), CCND2(1), CCND3(2), CCNE1(3), CCNE2(1), CCNH(2), CDC14A(6), CDC16(1), CDC20(2), CDC23(4), CDC25A(2), CDC25B(4), CDC25C(3), CDC26(1), CDC27(2), CDC6(2), CDC7(3), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(4), CDKN2D(1), CHEK1(2), CHEK2(5), CREBBP(13), CUL1(10), DBF4(5), E2F2(2), E2F3(1), EP300(15), ESPL1(12), FZR1(3), GSK3B(2), HDAC1(2), HDAC2(4), MAD1L1(6), MAD2L2(1), MCM2(9), MCM3(4), MCM4(6), MCM5(8), MCM6(1), MCM7(5), MDM2(3), ORC1L(10), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PKMYT1(3), PLK1(5), PRKDC(22), RB1(8), RBL1(5), RBL2(1), SKP2(4), SMAD2(8), SMAD3(2), SMAD4(9), SMC1A(4), SMC1B(3), TFDP1(2), TGFB1(3), TGFB2(6), TGFB3(4), TP53(67), WEE1(1), YWHAG(1), YWHAH(1), YWHAQ(2), YWHAZ(1)	27083171	430	107	400	148	124	124	19	84	77	2	0.32	1.00	1.00
292	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(2), ABLIM1(3), ABLIM2(3), ABLIM3(4), ARHGEF12(6), CDC42(1), CDK5(2), CFL1(1), CXCR4(2), DCC(19), DPYSL2(1), DPYSL5(4), EFNA1(2), EFNA2(2), EFNA5(2), EFNB1(1), EFNB2(4), EFNB3(4), EPHA1(8), EPHA2(5), EPHA3(12), EPHA4(7), EPHA5(14), EPHA6(15), EPHA7(3), EPHA8(9), EPHB1(14), EPHB2(11), EPHB3(6), EPHB4(4), EPHB6(6), FES(4), FYN(5), GNAI1(1), GNAI2(3), GNAI3(5), GSK3B(2), ITGB1(4), KRAS(17), L1CAM(3), LIMK1(4), LIMK2(4), LRRC4C(5), MAPK1(2), MAPK3(1), MET(4), NCK1(3), NCK2(2), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NGEF(5), NRAS(1), NRP1(11), NTN1(3), NTN4(1), NTNG1(6), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PLXNA1(13), PLXNA2(13), PLXNA3(11), PLXNB1(8), PLXNB2(10), PLXNB3(6), PLXNC1(9), PPP3CA(3), PPP3CB(1), PPP3R2(1), PTK2(7), RAC2(1), RAC3(1), RASA1(10), RGS3(11), RHOA(8), ROBO1(13), ROBO2(13), ROBO3(6), ROCK1(7), ROCK2(3), SEMA3A(5), SEMA3B(2), SEMA3D(8), SEMA3E(7), SEMA3F(8), SEMA3G(3), SEMA4A(5), SEMA4B(3), SEMA4C(5), SEMA4D(6), SEMA4F(3), SEMA5A(13), SEMA5B(5), SEMA6A(6), SEMA6B(2), SEMA6C(4), SEMA6D(9), SEMA7A(2), SLIT1(5), SLIT2(17), SLIT3(9), SRGAP1(9), SRGAP2(6), SRGAP3(5), UNC5A(6), UNC5B(5), UNC5C(9), UNC5D(7)	38870015	658	106	637	261	193	192	47	152	73	1	0.58	1.00	1.00
293	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRB1(3), ADRB2(4), ADRB3(1), ANXA6(2), ARRB1(3), ARRB2(3), ATP1A4(10), ATP1B3(2), ATP2A2(4), ATP2A3(4), ATP2B1(8), ATP2B2(9), ATP2B3(10), CACNA1A(11), CACNA1B(14), CACNA1C(23), CACNA1D(15), CACNA1E(26), CACNA1S(10), CACNB1(1), CALM1(1), CALM2(2), CALM3(1), CALR(4), CAMK1(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CAMK4(4), CASQ1(2), CASQ2(1), CHRM1(3), CHRM2(7), CHRM3(6), CHRM4(2), CHRM5(3), GJA1(8), GJA4(4), GJA5(2), GJB3(2), GJB6(2), GNA11(4), GNAI2(3), GNAI3(5), GNAO1(1), GNAQ(1), GNAZ(6), GNB1(1), GNB2(3), GNB3(1), GNB4(4), GNG12(1), GNG7(2), GNGT1(3), GRK4(1), GRK5(1), ITPR1(17), ITPR2(18), ITPR3(16), KCNB1(5), KCNJ3(6), KCNJ5(2), MIB1(2), NME7(1), PLCB3(8), PRKACA(1), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCQ(2), PRKD1(6), RGS1(1), RGS10(2), RGS11(2), RGS14(1), RGS16(2), RGS17(1), RGS18(3), RGS19(1), RGS2(2), RGS20(2), RGS3(11), RGS5(1), RGS6(7), RGS7(2), RGS9(4), RYR1(33), RYR2(43), RYR3(40), SLC8A1(6), SLC8A3(5), USP5(4), YWHAH(1), YWHAQ(2)	37386307	633	105	626	239	244	183	30	111	65	0	0.079	1.00	1.00
294	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(4), ACTG1(2), CHAD(4), COL11A1(15), COL11A2(8), COL17A1(5), COL1A1(7), COL1A2(17), COL2A1(8), COL3A1(8), COL4A1(13), COL4A2(7), COL4A4(7), COL4A6(7), COL5A1(14), COL5A2(6), COL5A3(5), COL6A1(7), COL6A2(8), COL6A3(21), COL6A6(20), COMP(3), DES(1), DSC1(3), DSC2(4), DSC3(4), DSG1(3), DSG2(2), DSG3(6), DSG4(4), FN1(21), GJA1(8), GJA10(2), GJA3(1), GJA4(4), GJA5(2), GJA8(1), GJA9(2), GJB3(2), GJB6(2), GJC2(3), GJD2(3), GJD4(4), IBSP(2), INA(3), ITGA6(2), ITGB4(12), KRT1(2), KRT10(4), KRT12(4), KRT13(7), KRT14(2), KRT15(1), KRT16(3), KRT17(2), KRT18(3), KRT2(6), KRT20(2), KRT23(1), KRT24(1), KRT25(2), KRT27(6), KRT28(5), KRT3(3), KRT31(3), KRT32(3), KRT33A(5), KRT33B(5), KRT34(1), KRT35(2), KRT36(3), KRT37(4), KRT38(1), KRT39(4), KRT4(1), KRT40(1), KRT5(3), KRT6A(5), KRT6B(1), KRT6C(2), KRT7(3), KRT71(2), KRT72(6), KRT73(6), KRT74(3), KRT75(2), KRT76(2), KRT77(2), KRT78(3), KRT79(2), KRT8(3), KRT81(2), KRT82(3), KRT83(2), KRT84(4), KRT85(2), KRT86(1), LAMA1(22), LAMA2(18), LAMA3(10), LAMA4(11), LAMA5(14), LAMB1(9), LAMB2(12), LAMB3(13), LAMB4(9), LAMC1(7), LAMC2(8), LAMC3(11), LMNA(5), LMNB1(2), LMNB2(3), NES(3), PRPH(1), RELN(21), SPP1(1), THBS1(9), THBS2(7), THBS3(4), THBS4(4), TNC(13), TNN(12), TNR(13), TNXB(26), VIM(2), VTN(4), VWF(13)	49259252	730	100	726	317	262	216	22	165	64	1	0.82	1.00	1.00
295	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(7), CADM1(9), CADM3(5), CD2(2), CD22(1), CD226(2), CD274(1), CD276(3), CD34(2), CD4(3), CD40(1), CD40LG(4), CD58(1), CD6(5), CD80(1), CD86(2), CD8A(2), CD8B(1), CDH1(14), CDH15(2), CDH2(10), CDH3(6), CDH4(12), CDH5(4), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(3), CLDN23(3), CLDN4(4), CLDN6(1), CLDN9(3), CNTN1(10), CNTN2(4), CNTNAP1(11), CNTNAP2(15), CTLA4(3), ESAM(6), GLG1(5), HLA-A(10), HLA-B(12), HLA-C(4), HLA-DMA(2), HLA-DMB(3), HLA-DOA(1), HLA-DPA1(2), HLA-DPB1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(3), HLA-DRB1(1), HLA-E(3), HLA-F(5), HLA-G(2), ICAM1(2), ICAM2(2), ICAM3(2), ICOS(1), ITGA4(8), ITGA6(2), ITGA8(5), ITGA9(9), ITGAL(7), ITGAM(5), ITGAV(4), ITGB1(4), ITGB2(6), ITGB7(3), ITGB8(7), JAM3(3), L1CAM(3), MADCAM1(2), MAG(6), MPZ(2), NCAM1(2), NCAM2(10), NEGR1(4), NEO1(8), NFASC(10), NLGN1(7), NLGN2(5), NLGN3(8), NRCAM(5), NRXN1(16), NRXN2(13), NRXN3(12), OCLN(1), PDCD1(2), PDCD1LG2(1), PTPRC(16), PTPRF(10), PTPRM(19), PVR(3), PVRL1(2), PVRL2(3), PVRL3(3), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SELE(3), SELL(4), SELP(2), SELPLG(6), SIGLEC1(10), VCAM1(5), VCAN(25)	29178708	541	100	534	206	164	172	20	133	50	2	0.15	1.00	1.00
296	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(9), CD36(2), CD44(5), CHAD(4), COL11A1(15), COL11A2(8), COL1A1(7), COL1A2(17), COL2A1(8), COL3A1(8), COL4A1(13), COL4A2(7), COL4A4(7), COL4A6(7), COL5A1(14), COL5A2(6), COL5A3(5), COL6A1(7), COL6A2(8), COL6A3(21), COL6A6(20), DAG1(7), FN1(21), FNDC1(9), FNDC3A(7), FNDC4(2), GP5(2), GP6(4), HMMR(4), HSPG2(16), IBSP(2), ITGA1(4), ITGA10(6), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGA7(5), ITGA8(5), ITGA9(9), ITGAV(4), ITGB1(4), ITGB3(5), ITGB4(12), ITGB5(3), ITGB6(1), ITGB7(3), ITGB8(7), LAMA1(22), LAMA2(18), LAMA3(10), LAMA4(11), LAMA5(14), LAMB1(9), LAMB2(12), LAMB3(13), LAMB4(9), LAMC1(7), LAMC2(8), LAMC3(11), RELN(21), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SPP1(1), SV2A(5), SV2B(1), SV2C(4), THBS1(9), THBS2(7), THBS3(4), THBS4(4), TNC(13), TNN(12), TNR(13), TNXB(26), VTN(4), VWF(13)	44369538	665	99	660	293	230	195	20	147	72	1	0.89	1.00	1.00
297	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(17), CCNA1(5), CCNB1(1), CCND1(1), CCND2(1), CCND3(2), CCNE1(3), CCNE2(1), CCNG2(1), CCNH(2), CDC25A(2), CDK2(2), CDKN1A(1), CDKN2A(4), CDKN2D(1), CREB3(3), CREB3L1(3), CREB3L3(3), CREB3L4(1), E2F2(2), E2F3(1), E2F5(1), GBA2(2), MCM2(9), MCM3(4), MCM4(6), MCM5(8), MCM6(1), MCM7(5), MDM2(3), MNAT1(2), MYT1(12), NACA(1), ORC1L(10), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(2), POLE(14), POLE2(2), PRIM1(1), RB1(8), RBL1(5), RPA1(1), RPA2(1), RPA3(1), TFDP1(2), TFDP2(3), TNXB(26), TP53(67), WEE1(1)	15227601	269	95	248	87	98	68	9	52	40	2	0.082	1.00	1.00
298	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(4), ACTG1(2), ACTN1(3), ACTN2(15), ACTN3(2), ACTN4(1), AKT1(2), AKT2(2), AKT3(3), AMOTL1(4), ASH1L(19), CASK(3), CDC42(1), CGN(8), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(3), CLDN23(3), CLDN4(4), CLDN6(1), CLDN9(3), CSDA(5), CSNK2A1(4), CSNK2A2(1), CTNNA1(5), CTNNA2(13), CTNNA3(5), CTNNB1(11), CTTN(2), EPB41(7), EPB41L1(4), EPB41L2(8), EPB41L3(14), EXOC3(5), EXOC4(4), GNAI1(1), GNAI2(3), GNAI3(5), HCLS1(1), IGSF5(2), INADL(5), JAM3(3), KRAS(17), LLGL1(8), LLGL2(4), MAGI1(16), MAGI2(10), MAGI3(5), MLLT4(16), MPDZ(14), MPP5(1), MYH1(8), MYH10(16), MYH11(12), MYH13(15), MYH14(11), MYH15(7), MYH2(14), MYH3(19), MYH4(12), MYH6(9), MYH7(13), MYH7B(12), MYH8(13), MYH9(13), MYL2(1), MYL7(1), NRAS(1), OCLN(1), PARD3(8), PARD6B(1), PARD6G(2), PPM1J(3), PPP2CA(3), PPP2CB(3), PPP2R1A(5), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(3), PPP2R3A(5), PPP2R3B(5), PPP2R4(2), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCI(6), PRKCQ(2), PTEN(8), RAB13(2), RAB3B(3), RHOA(8), RRAS(3), RRAS2(1), SPTAN1(13), SYMPK(5), TJAP1(2), TJP1(6), TJP2(5), TJP3(4), YES1(2), ZAK(3)	38508342	618	95	601	192	202	198	18	140	59	1	0.0026	1.00	1.00
299	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTA2(5), ACTN2(15), ACTN3(2), ACTN4(1), DES(1), DMD(23), FAM48A(5), MYBPC1(5), MYBPC2(5), MYBPC3(3), MYH3(19), MYH6(9), MYH7(13), MYH8(13), MYL1(1), MYL2(1), MYL3(1), MYL4(1), MYOM1(1), NEB(31), TCAP(1), TMOD1(3), TNNC2(1), TNNI2(5), TNNI3(1), TNNT1(2), TNNT2(2), TPM1(2), TPM3(2), TPM4(3), TTN(273), VIM(2)	27341629	453	95	450	151	124	140	23	136	27	3	0.12	1.00	1.00
300	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ACTA2(5), ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ARRB1(3), ARRB2(3), ATF4(1), ATF5(3), ATP2A2(4), ATP2A3(4), CALCA(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CNN1(1), CORIN(7), CREB3(3), CRHR1(2), DGKZ(1), ETS2(1), GABPA(1), GABPB2(1), GBA2(2), GJA1(8), GNAQ(1), GNB1(1), GNB2(3), GNB3(1), GNB4(4), GNG12(1), GNG7(2), GNGT1(3), GRK4(1), GRK5(1), GUCA2A(1), GUCY1A3(11), IGFBP1(2), IGFBP2(1), IGFBP3(4), IL1B(1), IL6(1), ITPR1(17), ITPR2(18), ITPR3(16), JUN(2), MIB1(2), MYL2(1), MYL4(1), MYLK2(3), NFKB1(5), NOS1(16), NOS3(3), OXT(2), OXTR(4), PDE4B(5), PLCB3(8), PLCD1(1), PLCG1(10), PLCG2(6), PRKACA(1), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(6), PRKCH(5), PRKCQ(2), PRKD1(6), RAMP2(1), RAMP3(3), RGS1(1), RGS10(2), RGS11(2), RGS14(1), RGS16(2), RGS17(1), RGS18(3), RGS19(1), RGS2(2), RGS20(2), RGS3(11), RGS5(1), RGS6(7), RGS7(2), RGS9(4), RYR1(33), RYR2(43), RYR3(40), SLC8A1(6), SP1(3), TNXB(26), USP5(4), YWHAH(1), YWHAQ(2)	34414719	530	94	526	216	202	141	18	119	50	0	0.50	1.00	1.00
301	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(4), ADORA2B(1), ADORA3(2), ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRA2A(2), ADRA2C(3), ADRB1(3), ADRB2(4), ADRB3(1), AGTR1(1), AGTR2(1), AVPR1A(7), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(3), C3AR1(2), CCBP2(3), CCKAR(2), CCKBR(4), CCR1(2), CCR10(2), CCR2(3), CCR3(4), CCR5(1), CCR6(1), CCR8(2), CCR9(1), CCRL1(5), CHML(2), CHRM1(3), CHRM2(7), CHRM3(6), CHRM4(2), CHRM5(3), CMKLR1(1), CNR1(5), CX3CR1(4), CXCR4(2), DRD1(3), DRD2(6), DRD3(8), DRD4(1), DRD5(10), EDNRA(3), EDNRB(13), F2R(2), F2RL1(3), F2RL2(1), FPR1(1), FSHR(17), GALR1(3), GALR2(1), GALR3(1), GALT(1), GHSR(4), GPR17(1), GPR173(3), GPR174(1), GPR27(2), GPR3(3), GPR35(3), GPR37(3), GPR37L1(4), GPR4(2), GPR50(5), GPR6(7), GPR83(5), GPR85(1), GPR87(4), GRPR(3), HCRTR1(3), HCRTR2(2), HRH1(3), HRH2(4), HRH3(3), HTR1A(6), HTR1B(5), HTR1D(4), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(5), HTR2C(3), HTR4(4), HTR5A(4), HTR6(1), HTR7(4), LHCGR(7), LTB4R(2), MAS1(2), MC3R(3), MC4R(4), MC5R(6), MLNR(2), MTNR1A(3), MTNR1B(2), NMBR(1), NMUR1(2), NMUR2(1), NPY1R(2), NPY2R(1), NPY5R(1), NTSR1(4), OPN1SW(1), OPN3(2), OPRD1(3), OPRK1(4), OPRL1(2), OR10A5(1), OR11A1(3), OR12D3(1), OR1F1(1), OR1Q1(4), OR2H1(1), OR5V1(4), OR7A5(1), OR7C1(3), OR8B8(6), OXTR(4), P2RY1(5), P2RY10(3), P2RY12(8), P2RY13(4), P2RY14(2), P2RY2(1), P2RY6(3), PPYR1(7), PTAFR(2), PTGDR(5), PTGER2(2), PTGER4(1), PTGFR(3), RGR(2), RHO(2), RRH(2), SSTR1(10), SSTR2(2), SSTR3(4), SSTR4(8), SUCNR1(2), TBXA2R(7), TRHR(6)	23936325	473	93	464	162	175	140	18	107	33	0	0.0041	1.00	1.00
302	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(4), ACVR1B(7), ACVR2A(18), ACVR2B(3), AMHR2(3), BMP2(2), BMP7(2), BMPR1A(1), BMPR1B(3), BMPR2(10), CCL11(1), CCL15(1), CCL18(2), CCL2(1), CCL20(1), CCL23(1), CCL25(1), CCL27(1), CCL5(1), CCL7(1), CCL8(2), CCR1(2), CCR2(3), CCR3(4), CCR5(1), CCR6(1), CCR8(2), CCR9(1), CD27(2), CD40(1), CD40LG(4), CD70(1), CLCF1(1), CNTF(2), CNTFR(3), CSF1R(7), CSF2RA(6), CSF2RB(7), CSF3(1), CSF3R(6), CX3CL1(5), CX3CR1(4), CXCL16(2), CXCL2(1), CXCL9(1), CXCR4(2), CXCR6(1), EDA(1), EDAR(5), EGF(5), EGFR(10), EPOR(2), FAS(3), FLT1(6), FLT3(7), FLT4(8), GDF5(5), GH1(3), GH2(3), GHR(5), HGF(11), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(5), IFNAR2(4), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), IFNK(1), IFNW1(1), IL10(1), IL10RA(2), IL10RB(1), IL11(2), IL11RA(2), IL12B(2), IL12RB1(4), IL12RB2(5), IL13(2), IL13RA1(2), IL15RA(1), IL17B(1), IL17RA(6), IL17RB(1), IL18R1(2), IL18RAP(2), IL1B(1), IL1R1(3), IL1R2(1), IL1RAP(3), IL2(1), IL20(1), IL20RA(3), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(5), IL25(2), IL26(1), IL28A(2), IL28B(3), IL2RA(1), IL2RG(3), IL3(1), IL3RA(4), IL4R(1), IL5RA(1), IL6(1), IL6ST(2), IL7R(3), IL8(1), INHBA(6), INHBB(9), INHBC(1), INHBE(1), KDR(7), KIT(6), KITLG(3), LEPR(8), LIF(2), LIFR(7), LTA(2), LTBR(2), MET(4), NGFR(5), OSM(4), OSMR(3), PDGFB(3), PDGFC(3), PDGFRA(4), PDGFRB(8), PF4V1(1), PRL(2), PRLR(2), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6), TNF(2), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(2), TNFRSF10D(2), TNFRSF11A(4), TNFRSF11B(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF19(3), TNFRSF1A(3), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(2), TNFRSF8(2), TNFRSF9(3), TNFSF10(2), TNFSF11(1), TNFSF15(1), TNFSF18(2), TNFSF8(1), TPO(13), TSLP(4), VEGFC(3), XCL1(1), XCR1(3)	34994938	508	93	489	196	148	158	24	114	62	2	0.43	1.00	1.00
303	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTB(4), ACTG1(2), ACTN1(3), ACTN2(15), ACTN3(2), ACTN4(1), ACVR1B(7), ACVR1C(3), BAIAP2(3), CDC42(1), CDH1(14), CREBBP(13), CSNK2A1(4), CSNK2A2(1), CTNNA1(5), CTNNA2(13), CTNNA3(5), CTNNB1(11), CTNND1(7), EGFR(10), EP300(15), ERBB2(6), FARP2(4), FER(7), FGFR1(8), FYN(5), IGF1R(11), INSR(10), IQGAP1(5), LEF1(4), LMO7(9), MAP3K7(7), MAPK1(2), MAPK3(1), MET(4), MLLT4(16), NLK(5), PARD3(8), PTPN6(3), PTPRB(12), PTPRF(10), PTPRJ(14), PTPRM(19), PVRL1(2), PVRL2(3), PVRL3(3), PVRL4(4), RAC2(1), RAC3(1), RHOA(8), SMAD2(8), SMAD3(2), SMAD4(9), SNAI1(2), SNAI2(4), SORBS1(7), SSX2IP(3), TCF7(2), TCF7L1(3), TCF7L2(5), TGFBR1(2), TGFBR2(6), TJP1(6), VCL(2), WASF1(4), WASF2(2), WASF3(3), WASL(1), YES1(2)	23728242	404	90	393	133	113	136	13	81	61	0	0.045	1.00	1.00
304	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(1), BAK1(2), BFAR(1), BTK(2), CAD(7), CASP10(3), CASP3(1), CASP8(6), CASP8AP2(9), CD7(4), DAXX(3), DEDD(1), DEDD2(2), DFFA(2), DIABLO(1), EGFR(10), EPHB2(11), FAF1(4), FAIM2(1), HSPB1(1), IL8(1), MAP2K4(5), MAP2K7(13), MAP3K1(8), MAP3K5(3), MAPK1(2), MAPK10(3), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3), MET(4), NFAT5(5), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), NR0B2(2), PFN2(2), PTPN13(14), RALBP1(7), ROCK1(7), SMPD1(4), TP53(67), TPX2(4), TRAF2(2), TUFM(3)	14504814	264	90	241	80	84	68	9	54	48	1	0.061	1.00	1.00
305	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(3), ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ADK(1), ADSL(4), ADSS(3), ADSSL1(7), AK5(3), AK7(2), ALLC(3), AMPD1(3), AMPD2(5), AMPD3(7), APRT(2), ATIC(5), CANT1(4), DCK(1), DGUOK(1), ENPP1(1), ENPP3(3), ENTPD1(3), ENTPD3(3), ENTPD4(6), ENTPD6(1), ENTPD8(4), FHIT(1), GART(6), GDA(1), GMPR(3), GMPR2(2), GMPS(3), GUCY1A2(6), GUCY1A3(11), GUCY1B3(7), GUCY2C(6), GUCY2D(8), GUCY2F(7), GUK1(2), IMPDH1(1), IMPDH2(1), NME6(3), NME7(1), NPR1(6), NPR2(5), NT5C(1), NT5C1A(1), NT5C1B(4), NT5C2(5), NUDT2(2), NUDT5(1), NUDT9(1), PAPSS1(4), PAPSS2(2), PDE10A(1), PDE11A(2), PDE1A(3), PDE1C(3), PDE2A(6), PDE3B(10), PDE4A(4), PDE4B(5), PDE4C(2), PDE5A(5), PDE6G(1), PDE7A(5), PDE7B(3), PDE8A(6), PDE8B(3), PDE9A(5), PFAS(2), PKLR(4), PKM2(2), PNPT1(3), POLA1(4), POLA2(2), POLD1(7), POLD3(2), POLE(14), POLE2(2), POLE3(1), POLE4(1), POLR1A(8), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(6), POLR3G(1), POLR3K(1), PPAT(1), PRIM1(1), PRIM2(3), PRPS1(1), PRPS1L1(2), PRPS2(3), PRUNE(3), RRM1(4), RRM2(2), RRM2B(2), XDH(9)	32387372	433	89	432	163	144	153	16	91	29	0	0.27	1.00	1.00
306	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ADRB1(3), CSNK1D(2), DRD1(3), DRD2(6), EGF(5), EGFR(10), GJA1(8), GJD2(3), GNA11(4), GNAI1(1), GNAI2(3), GNAI3(5), GNAQ(1), GNAS(14), GRB2(1), GRM1(17), GRM5(14), GUCY1A2(6), GUCY1A3(11), GUCY1B3(7), GUCY2C(6), GUCY2D(8), GUCY2F(7), HTR2A(2), HTR2B(5), HTR2C(3), ITPR1(17), ITPR2(18), ITPR3(16), KRAS(17), MAP2K1(4), MAP2K2(1), MAP2K5(1), MAP3K2(2), MAPK1(2), MAPK3(1), MAPK7(8), NPR1(6), NPR2(5), NRAS(1), PDGFA(1), PDGFB(3), PDGFC(3), PDGFD(3), PDGFRA(4), PDGFRB(8), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKG1(6), PRKG2(6), PRKX(2), RAF1(6), SOS1(4), SOS2(5), TJP1(6), TUBA1B(1), TUBA1C(2), TUBA3C(6), TUBA3D(5), TUBA3E(5), TUBA8(3), TUBAL3(3), TUBB1(4), TUBB2A(2), TUBB2C(2), TUBB3(8), TUBB4(1), TUBB4Q(2), TUBB6(5), TUBB8(2)	26203303	473	87	460	170	161	152	24	106	30	0	0.10	1.00	1.00
307	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(2), AKT2(2), AKT3(3), BCL10(1), CARD11(12), CBL(2), CBLB(2), CBLC(2), CD247(2), CD3E(3), CD3G(2), CD4(3), CD40LG(4), CD8A(2), CD8B(1), CDC42(1), CTLA4(3), FYN(5), GRAP2(1), GRB2(1), ICOS(1), IFNG(2), IKBKB(3), IL10(1), IL2(1), ITK(4), JUN(2), KRAS(17), LCK(1), LCP2(7), MALT1(5), MAP3K14(3), MAP3K8(1), NCK1(3), NCK2(2), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NFKB1(5), NFKB2(3), NFKBIB(4), NRAS(1), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PDCD1(2), PDK1(1), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLCG1(10), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKCQ(2), PTPN6(3), PTPRC(16), RASGRP1(4), RHOA(8), SOS1(4), SOS2(5), TEC(3), TNF(2), VAV1(7), VAV2(8), VAV3(6), ZAP70(4)	20078978	341	86	309	116	82	131	10	83	35	0	0.13	1.00	1.00
308	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(2), AKT2(2), AKT3(3), CBL(2), CBLB(2), CBLC(2), CCND1(1), CCND2(1), CCND3(2), CISH(2), CLCF1(1), CNTF(2), CNTFR(3), CREBBP(13), CSF2RA(6), CSF2RB(7), CSF3(1), CSF3R(6), EP300(15), EPOR(2), GH1(3), GH2(3), GHR(5), GRB2(1), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(5), IFNAR2(4), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), IFNK(1), IFNW1(1), IL10(1), IL10RA(2), IL10RB(1), IL11(2), IL11RA(2), IL12B(2), IL12RB1(4), IL12RB2(5), IL13(2), IL13RA1(2), IL13RA2(7), IL15RA(1), IL2(1), IL20(1), IL20RA(3), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(5), IL26(1), IL28A(2), IL28B(3), IL2RA(1), IL2RG(3), IL3(1), IL3RA(4), IL4R(1), IL5RA(1), IL6(1), IL6ST(2), IL7R(3), IRF9(4), JAK1(4), JAK2(8), JAK3(3), LEPR(8), LIF(2), LIFR(7), OSM(4), OSMR(3), PIAS1(3), PIAS2(5), PIAS3(1), PIAS4(4), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PIM1(2), PRL(2), PRLR(2), PTPN11(4), PTPN6(3), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(3), SOCS7(2), SOS1(4), SOS2(5), SPRED1(3), SPRED2(6), SPRY1(2), SPRY2(1), SPRY3(4), SPRY4(3), STAM(4), STAM2(3), STAT1(6), STAT2(4), STAT3(7), STAT4(4), STAT5A(1), STAT5B(4), TPO(13), TSLP(4), TYK2(6)	28754939	428	85	410	143	113	157	20	94	43	1	0.054	1.00	1.00
309	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), AKAP1(1), AKAP10(2), AKAP11(5), AKAP12(5), AKAP3(5), AKAP4(8), AKAP6(11), AKAP7(6), AKAP8(7), AKAP9(16), ARHGEF1(2), CALM1(1), CALM2(2), CALM3(1), CHMP1B(2), GNA11(4), GNA12(1), GNA14(2), GNA15(2), GNAI2(3), GNAI3(5), GNAO1(1), GNAQ(1), GNAZ(6), GNB1(1), GNB2(3), GNB3(1), GNG12(1), GNG7(2), GNGT1(3), GNGT2(1), ITPR1(17), KCNJ3(6), KRAS(17), NRAS(1), PDE1A(3), PDE1B(2), PDE1C(3), PDE4A(4), PDE4B(5), PDE4C(2), PDE7A(5), PDE7B(3), PDE8A(6), PDE8B(3), PLCB3(8), PPP3CA(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCI(6), PRKCQ(2), PRKD1(6), PRKD3(1), RHOA(8), RRAS(3), SLC9A1(6), USP5(4)	23201314	338	84	318	123	111	115	10	65	37	0	0.14	1.00	1.00
310	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ATF4(1), CACNA1C(23), CACNA1D(15), CACNA1F(2), CACNA1S(10), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CDC42(1), EGFR(10), ELK1(2), FSHB(2), GNA11(4), GNAQ(1), GNAS(14), GNRH1(1), GNRH2(1), GNRHR(3), GRB2(1), ITPR1(17), ITPR2(18), ITPR3(16), JUN(2), KRAS(17), LHB(1), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(13), MAP3K1(8), MAP3K2(2), MAP3K3(2), MAP3K4(10), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(8), MAPK8(4), MAPK9(3), MMP14(1), MMP2(4), NRAS(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLD1(7), PLD2(11), PRKACA(1), PRKACB(2), PRKACG(3), PRKCD(3), PRKX(2), PTK2B(8), RAF1(6), SOS1(4), SOS2(5)	25251762	425	84	414	141	143	146	15	77	44	0	0.015	1.00	1.00
311	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADCY9(6), ASIP(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CREB1(4), CREB3(3), CREB3L1(3), CREB3L2(1), CREB3L3(3), CREB3L4(1), CREBBP(13), CTNNB1(11), DCT(7), DVL1(4), DVL2(3), DVL3(5), EDN1(3), EDNRB(13), EP300(15), FZD1(8), FZD10(8), FZD2(3), FZD3(4), FZD4(2), FZD5(1), FZD6(8), FZD7(2), FZD8(4), GNAI1(1), GNAI2(3), GNAI3(5), GNAO1(1), GNAQ(1), GNAS(14), GSK3B(2), KIT(6), KITLG(3), KRAS(17), LEF1(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MITF(6), NRAS(1), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), POMC(5), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), RAF1(6), TCF7(2), TCF7L1(3), TCF7L2(5), TYR(5), TYRP1(5), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(5), WNT3A(1), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2)	21429050	399	84	383	153	139	126	12	77	44	1	0.19	1.00	1.00
312	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(15), ACACB(13), AKT1(2), AKT2(2), AKT3(3), ARAF(6), BAD(1), BRAF(5), CALM1(1), CALM2(2), CALM3(1), CBL(2), CBLB(2), CBLC(2), CRK(1), EIF4EBP1(1), ELK1(2), EXOC7(6), FASN(11), FBP1(1), FBP2(3), FLOT1(1), FLOT2(3), FOXO1(1), GCK(3), GRB2(1), GSK3B(2), GYS1(4), GYS2(2), IKBKB(3), INPP5D(1), INSR(10), IRS1(7), IRS2(3), IRS4(11), KRAS(17), LIPE(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK9(3), MKNK1(1), NRAS(1), PCK1(4), PCK2(6), PDE3A(8), PDE3B(10), PDPK1(1), PFKL(7), PFKM(3), PFKP(8), PHKA1(5), PHKA2(7), PHKB(3), PHKG1(2), PHKG2(3), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PKLR(4), PKM2(2), PPARGC1A(6), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R3A(12), PPP1R3B(5), PPP1R3C(3), PPP1R3D(3), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAB2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAG3(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKCI(6), PRKX(2), PTPRF(10), PYGB(4), PYGL(5), PYGM(7), RAF1(6), RAPGEF1(6), RHEB(1), RPS6(1), RPS6KB1(3), RPS6KB2(3), SH2B2(3), SHC1(3), SHC2(2), SHC3(4), SHC4(1), SLC2A4(1), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(3), SORBS1(7), SOS1(4), SOS2(5), SREBF1(4), TRIP10(7), TSC1(4), TSC2(4)	31585310	498	83	473	184	155	181	18	94	49	1	0.14	1.00	1.00
313	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(1), CALM2(2), CALM3(1), CDS1(4), CDS2(1), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKI(5), DGKQ(2), DGKZ(1), FN3K(2), IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(3), INPP5B(2), INPP5D(1), INPP5E(2), INPPL1(13), ITGB1BP3(3), ITPK1(2), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), OCRL(4), PI4KA(10), PI4KB(4), PIK3C2A(4), PIK3C2B(12), PIK3C2G(3), PIK3C3(8), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1C(6), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLCD1(1), PLCD3(6), PLCE1(9), PLCG1(10), PLCG2(6), PLCZ1(2), PRKCG(4), PTEN(8), PTPMT1(1), SYNJ1(7), SYNJ2(15)	24750947	373	82	351	119	116	127	13	74	42	1	0.023	1.00	1.00
314	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(4), ACVR1B(7), ACVR1C(3), ACVR2A(18), ACVR2B(3), ACVRL1(2), AMHR2(3), BMP2(2), BMP4(6), BMP5(6), BMP6(5), BMP7(2), BMP8A(1), BMP8B(2), BMPR1A(1), BMPR1B(3), BMPR2(10), CHRD(1), COMP(3), CREBBP(13), CUL1(10), DCN(2), E2F5(1), EP300(15), FST(1), GDF5(5), GDF6(6), GDF7(1), IFNG(2), INHBA(6), INHBB(9), INHBC(1), INHBE(1), LEFTY2(2), LTBP1(12), MAPK1(2), MAPK3(1), PITX2(2), PPP2CA(3), PPP2CB(3), PPP2R1A(5), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(3), RBL1(5), RBL2(1), RHOA(8), ROCK1(7), ROCK2(3), RPS6KB1(3), RPS6KB2(3), SMAD1(1), SMAD2(8), SMAD3(2), SMAD4(9), SMAD5(1), SMAD6(3), SMAD7(2), SMAD9(6), SMURF1(1), SMURF2(1), SP1(3), TFDP1(2), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6), THBS1(9), THBS2(7), THBS3(4), THBS4(4), TNF(2), ZFYVE16(6), ZFYVE9(2)	19520020	322	82	298	116	109	91	15	51	54	2	0.30	1.00	1.00
315	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(3), ACTN2(15), ACTN3(2), ACTN4(1), ARHGAP5(6), BCAR1(4), CDC42(1), CDH5(4), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(3), CLDN23(3), CLDN4(4), CLDN6(1), CLDN9(3), CTNNA1(5), CTNNA2(13), CTNNA3(5), CTNNB1(11), CTNND1(7), CXCR4(2), CYBA(1), CYBB(4), ESAM(6), GNAI1(1), GNAI2(3), GNAI3(5), GRLF1(8), ICAM1(2), ITGA4(8), ITGAL(7), ITGAM(5), ITGB1(4), ITGB2(6), ITK(4), JAM3(3), MAPK11(1), MAPK13(1), MAPK14(1), MLLT4(16), MMP2(4), MMP9(6), MSN(3), MYL2(1), MYL7(1), NCF1(2), NCF2(1), NCF4(1), NOX1(4), NOX3(3), OCLN(1), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLCG1(10), PLCG2(6), PRKCG(4), PTK2(7), PTK2B(8), PTPN11(4), PXN(2), RAC2(1), RAP1A(2), RAP1B(4), RAPGEF3(2), RAPGEF4(3), RASSF5(1), RHOA(8), RHOH(1), ROCK1(7), ROCK2(3), TXK(1), VASP(3), VAV1(7), VAV2(8), VAV3(6), VCAM1(5), VCL(2)	24584043	403	81	378	157	131	138	15	74	44	1	0.38	1.00	1.00
316	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(4), ACVR1B(7), ACVRL1(2), AKT1(2), AURKB(2), BMPR1A(1), BMPR2(10), BUB1(6), CDKL1(3), CDKL2(3), CDS1(4), CDS2(1), CLK1(3), CLK2(6), CLK4(3), COL4A3BP(1), CSNK2A1(4), CSNK2A2(1), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKQ(2), DGKZ(1), IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(3), INPPL1(13), ITPKA(1), ITPKB(6), MAP3K10(6), MOS(3), NEK1(4), NEK3(1), OCRL(4), PAK4(5), PIK3C2A(4), PIK3C2B(12), PIK3C2G(3), PIK3CA(33), PIK3CB(6), PIK3CG(10), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLCD1(1), PLCG1(10), PLCG2(6), PLK3(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCQ(2), PRKD1(6), PRKG1(6), RAF1(6), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA4(2), RPS6KB1(3), TGFBR1(2), VRK1(2)	22409505	342	81	322	111	99	113	13	76	38	3	0.12	1.00	1.00
317	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(11), ADCY8(12), ARAF(6), ATF4(1), BRAF(5), CACNA1C(23), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CAMK4(4), CREBBP(13), EP300(15), GNAQ(1), GRIA1(11), GRIA2(13), GRIN1(4), GRIN2A(7), GRIN2B(13), GRIN2C(4), GRIN2D(1), GRM1(17), GRM5(14), ITPR1(17), ITPR2(18), ITPR3(16), KRAS(17), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), NRAS(1), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PPP1CA(2), PPP1CB(1), PPP1CC(2), PPP1R12A(1), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), RAF1(6), RAP1A(2), RAP1B(4), RAPGEF3(2), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA6(7)	19778105	353	80	343	116	108	128	13	62	42	0	0.028	1.00	1.00
318	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(6), BRAF(5), CACNA1A(11), CRHR1(2), GNA11(4), GNA12(1), GNAI1(1), GNAI2(3), GNAI3(5), GNAO1(1), GNAQ(1), GNAS(14), GNAZ(6), GRIA1(11), GRIA2(13), GRIA3(6), GRID2(11), GRM1(17), GRM5(14), GUCY1A2(6), GUCY1A3(11), GUCY1B3(7), GUCY2C(6), GUCY2D(8), GUCY2F(7), IGF1(2), IGF1R(11), ITPR1(17), ITPR2(18), ITPR3(16), KRAS(17), LYN(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), NOS1(16), NOS3(3), NPR1(6), NPR2(5), NRAS(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PPP2CA(3), PPP2CB(3), PPP2R1A(5), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(3), PRKCG(4), PRKG1(6), PRKG2(6), RAF1(6), RYR1(33)	21830202	433	80	420	128	148	131	21	102	31	0	0.0038	1.00	1.00
319	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(2), ABL2(3), AKT1(2), AKT2(2), AKT3(3), ARAF(6), BAD(1), BRAF(5), BTC(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CBL(2), CBLB(2), CBLC(2), CDKN1A(1), CRK(1), EGF(5), EGFR(10), EIF4EBP1(1), ELK1(2), ERBB2(6), ERBB3(21), ERBB4(18), EREG(2), GAB1(1), GRB2(1), GSK3B(2), JUN(2), KRAS(17), MAP2K1(4), MAP2K2(1), MAP2K4(5), MAP2K7(13), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK9(3), NCK1(3), NCK2(2), NRAS(1), NRG1(9), NRG2(5), NRG3(9), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLCG1(10), PLCG2(6), PRKCG(4), PTK2(7), RAF1(6), RPS6KB1(3), RPS6KB2(3), SHC1(3), SHC2(2), SHC3(4), SHC4(1), SOS1(4), SOS2(5), STAT5A(1), STAT5B(4), TGFA(2)	20317623	353	79	322	115	94	131	15	72	41	0	0.042	1.00	1.00
320	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	125	ARAF(6), BID(1), BRAF(5), CASP3(1), CD244(1), CD247(2), FAS(3), FCGR3A(1), FCGR3B(2), FYN(5), GRB2(1), HLA-A(10), HLA-B(12), HLA-C(4), HLA-E(3), HLA-G(2), ICAM1(2), ICAM2(2), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(5), IFNAR2(4), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), ITGAL(7), ITGB2(6), KIR2DL1(4), KIR2DL3(1), KIR2DL4(3), KIR3DL1(2), KLRC1(2), KLRC2(2), KLRD1(2), KRAS(17), LCK(1), LCP2(7), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MICB(1), NCR1(1), NCR2(3), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NRAS(1), PAK1(4), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLCG1(10), PLCG2(6), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRF1(1), PRKCG(4), PTK2B(8), PTPN11(4), PTPN6(3), RAC2(1), RAC3(1), RAF1(6), SH2D1A(1), SH2D1B(1), SH3BP2(3), SHC1(3), SHC2(2), SHC3(4), SHC4(1), SOS1(4), SOS2(5), SYK(3), TNF(2), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(2), TNFRSF10D(2), TNFSF10(2), ULBP1(2), ULBP3(1), VAV1(7), VAV2(8), VAV3(6), ZAP70(4)	22304147	391	79	364	117	93	149	18	79	50	2	0.0034	1.00	1.00
321	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(3), ADCY1(11), ADCY2(8), ADCY3(3), ADCY4(5), ADCY5(9), ADCY6(5), ADCY7(10), ADCY8(12), ADK(1), ADSL(4), ADSS(3), AK5(3), ALLC(3), AMPD1(3), AMPD2(5), AMPD3(7), APRT(2), ATIC(5), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5G3(1), ATP5J(1), ATP5J2(1), CANT1(4), DCK(1), DGUOK(1), ENPP1(1), ENPP3(3), ENTPD1(3), FHIT(1), GART(6), GDA(1), GMPS(3), GUCY1A2(6), GUCY1A3(11), GUCY1B3(7), GUCY2C(6), GUCY2D(8), GUCY2F(7), GUK1(2), IMPDH1(1), IMPDH2(1), NPR1(6), NPR2(5), NT5C(1), NUDT2(2), PAPSS1(4), PAPSS2(2), PDE1A(3), PDE4A(4), PDE4B(5), PDE4C(2), PDE5A(5), PDE6B(7), PDE6C(2), PDE6G(1), PDE7B(3), PDE8A(6), PDE9A(5), PFAS(2), PKLR(4), PKM2(2), POLD1(7), POLE(14), POLG(4), POLL(1), POLQ(14), POLR1B(2), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(9), PPAT(1), PRPS1(1), PRPS1L1(2), PRPS2(3), PRUNE(3), RRM1(4), RRM2(2)	25367375	338	79	337	139	106	124	13	73	22	0	0.62	1.00	1.00
322	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(2), ACTN1(3), ACTR2(2), AKT1(2), AKT2(2), AKT3(3), ANGPTL2(4), ARHGEF6(10), ARHGEF7(9), BCAR1(4), BRAF(5), CAV1(2), CDC42(1), CDKN2A(4), CRK(1), CSE1L(3), DOCK1(12), EPHB2(11), FYN(5), GRB2(1), GRB7(6), GRLF1(8), ILK(2), ITGA1(4), ITGA10(6), ITGA11(6), ITGA2(4), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGA7(5), ITGA8(5), ITGA9(9), ITGB3BP(1), MAP2K4(5), MAP2K7(13), MAP3K11(3), MAPK1(2), MAPK10(3), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3), MYLK(9), MYLK2(3), P4HB(4), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PIK3CA(33), PIK3CB(6), PKLR(4), PLCG1(10), PLCG2(6), PTEN(8), PTK2(7), RAF1(6), RHO(2), ROCK1(7), ROCK2(3), SHC1(3), SOS1(4), SOS2(5), TERF2IP(3), TLN1(13), TLN2(22), VASP(3), ZYX(2)	24258823	391	78	373	127	125	123	15	77	51	0	0.048	1.00	1.00
323	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(3), BCAR1(4), CAPN1(3), CAPN10(1), CAPN11(3), CAPN2(4), CAPN3(5), CAPN5(2), CAPN6(8), CAPN7(5), CAPN9(3), CAPNS1(1), CAV1(2), CDC42(1), CRK(1), CSK(3), DOCK1(12), FYN(5), GIT2(1), GRB2(1), ILK(2), ITGA10(6), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGA7(5), ITGA8(5), ITGA9(9), ITGAD(6), ITGAE(4), ITGAL(7), ITGAM(5), ITGAV(4), ITGAX(6), ITGB1(4), ITGB2(6), ITGB3(5), ITGB4(12), ITGB5(3), ITGB6(1), ITGB7(3), ITGB8(7), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K6(2), MAPK10(3), MAPK4(4), MAPK6(1), MAPK7(8), MYLK2(3), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PDPK1(1), PIK3R2(4), PTK2(7), PXN(2), RAC2(1), RAC3(1), RAP1B(4), RAPGEF1(6), RHO(2), ROCK1(7), ROCK2(3), SHC1(3), SHC3(4), SORBS1(7), SOS1(4), TLN1(13), TNS1(15), VASP(3), VAV2(8), VAV3(6), VCL(2), ZYX(2)	26589722	357	77	355	149	122	105	15	70	44	1	0.75	1.00	1.00
324	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(3), ALG1(3), ALG10(5), ALG10B(2), ALG12(1), ALG13(2), ALG2(1), ALG3(2), ALG8(1), ALG9(2), B3GNT1(1), B3GNT2(1), B3GNT7(4), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), B4GALT5(3), B4GALT7(1), C1GALT1(1), C1GALT1C1(4), CHPF(2), CHST1(11), CHST11(1), CHST12(6), CHST13(1), CHST2(8), CHST3(1), CHST6(5), CHST7(1), CHSY1(3), EXT1(9), EXT2(6), EXTL1(4), EXTL2(2), EXTL3(8), FUT11(2), FUT8(3), GALNT1(3), GALNT10(3), GALNT11(5), GALNT12(2), GALNT13(3), GALNT14(6), GALNT2(3), GALNT3(1), GALNT4(1), GALNT5(4), GALNT6(2), GALNT8(5), GALNT9(3), GALNTL1(2), GALNTL2(6), GALNTL4(5), GALNTL5(4), GANAB(3), GCNT1(1), GCNT3(2), GCNT4(2), HS2ST1(1), HS3ST1(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), HS3ST5(4), HS6ST1(2), HS6ST2(1), HS6ST3(4), MAN1A2(1), MAN1B1(2), MAN1C1(3), MAN2A1(7), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(1), MGAT5(6), MGAT5B(3), NDST1(8), NDST2(5), NDST3(5), NDST4(10), OGT(2), RPN1(1), RPN2(3), ST3GAL1(3), ST3GAL2(4), ST3GAL3(2), ST3GAL4(3), ST6GALNAC1(2), STT3B(5), UST(5), WBSCR17(14), XYLT1(7), XYLT2(4)	21750585	327	76	322	136	121	102	12	67	25	0	0.74	1.00	1.00
325	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(2), AKT2(2), AKT3(3), CASP8(6), CCL5(1), CD14(1), CD40(1), CD80(1), CD86(2), CXCL9(1), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), IFNAR1(5), IFNAR2(4), IFNB1(2), IKBKB(3), IKBKE(5), IL12B(2), IL1B(1), IL6(1), IL8(1), IRAK1(5), IRAK4(3), IRF3(3), IRF5(2), IRF7(1), JUN(2), LY96(1), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(13), MAP3K7(7), MAP3K8(1), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), MAPK9(3), MYD88(2), NFKB1(5), NFKB2(3), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), RELA(2), SPP1(1), STAT1(6), TBK1(2), TICAM1(6), TIRAP(2), TLR1(5), TLR2(3), TLR3(2), TLR4(13), TLR5(4), TLR6(3), TLR7(3), TLR8(6), TLR9(10), TNF(2), TOLLIP(1), TRAF3(2), TRAF6(4)	17728133	286	76	265	90	75	98	18	62	33	0	0.041	1.00	1.00
326	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(2), AKT2(2), AKT3(3), BAD(1), CDC42(1), CDK2(2), CDKN2A(4), CREB1(4), CREB3(3), CREB5(2), EBP(1), ERBB4(18), F2RL2(1), GAB1(1), GRB2(1), GSK3A(1), GSK3B(2), IGF1(2), IGFBP1(2), INPPL1(13), IRS1(7), IRS2(3), IRS4(11), MET(4), NOLC1(7), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PARD3(8), PDK1(1), PIK3CA(33), PIK3CD(8), PPP1R13B(6), PREX1(9), PTEN(8), PTK2(7), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KB1(3), SHC1(3), SLC2A4(1), SOS1(4), SOS2(5), TSC1(4), TSC2(4), YWHAG(1), YWHAH(1), YWHAQ(2), YWHAZ(1)	15261438	241	76	224	80	75	85	13	37	31	0	0.072	1.00	1.00
327	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(13), BDKRB1(1), BDKRB2(3), C1QA(1), C1QC(3), C1R(5), C1S(4), C2(2), C3(16), C3AR1(2), C5(9), C5AR1(1), C6(8), C7(2), C8A(6), C8B(8), C9(3), CD46(1), CD55(1), CD59(1), CFB(3), CFH(12), CFI(3), CPB2(4), CR1(17), CR2(4), F10(3), F11(3), F12(2), F13A1(9), F13B(8), F2(4), F2R(2), F3(1), F5(9), F7(6), F8(13), F9(4), FGA(5), FGB(3), FGG(2), KLKB1(4), KNG1(4), MASP1(4), MASP2(2), MBL2(1), PLAT(2), PLAU(2), PLG(10), PROC(3), PROS1(6), SERPINA1(4), SERPINA5(1), SERPINC1(2), SERPIND1(3), SERPINE1(2), SERPINF2(6), SERPING1(6), TFPI(3), THBD(1), VWF(13)	17979520	286	75	283	76	78	85	8	79	33	3	0.0035	1.00	1.00
328	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(2), BCL2(1), EGFR(10), IGF1R(11), POLR2A(9), PPP2CA(3), RB1(8), TEP1(14), TERF1(1), TERT(3), TNKS(6), TP53(67), XRCC5(3)	5582950	138	75	118	41	41	42	4	23	27	1	0.059	1.00	1.00
329	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(19), ASH2L(3), C17orf79(2), CARM1(2), CTCFL(5), DOT1L(9), EED(2), EHMT1(7), EHMT2(4), EZH1(2), EZH2(4), FBXO11(6), HCFC1(11), HSF4(2), JMJD4(1), JMJD6(1), KDM6A(6), MEN1(3), MLL(16), MLL2(32), MLL3(36), MLL4(24), MLL5(11), NSD1(13), OGT(2), PAXIP1(6), PPP1CA(2), PPP1CB(1), PPP1CC(2), PRDM2(15), PRDM9(9), PRMT1(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), RBBP5(1), SATB1(8), SETD1A(7), SETD2(4), SETDB1(12), SETDB2(3), SMYD3(2), STK38(1), SUV39H1(4), SUV39H2(1), SUV420H1(4), SUV420H2(1), SUZ12(4), WHSC1(7), WHSC1L1(7)	23513953	335	73	330	116	103	94	7	69	55	7	0.45	1.00	1.00
330	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(4), BAD(1), BCL2(1), CABIN1(8), CALM1(1), CALM2(2), CALM3(1), CAMK2B(2), CAMK4(4), CD3E(3), CD3G(2), CDKN1A(1), CNR1(5), CREBBP(13), CSNK2A1(4), CTLA4(3), EGR2(3), EGR3(1), EP300(15), FCER1A(1), FCGR3A(1), GATA3(3), GATA4(3), GRLF1(8), GSK3A(1), GSK3B(2), ICOS(1), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL13(2), IL1B(1), IL2(1), IL2RA(1), IL3(1), IL6(1), IL8(1), ITK(4), KPNA5(5), MAP2K7(13), MAPK14(1), MAPK8(4), MAPK9(3), MEF2A(1), MEF2B(3), MEF2D(6), MYF5(2), NCK2(2), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NFKB2(3), NFKBIB(4), NPPB(1), NUP214(12), OPRD1(3), PAK1(4), PIN1(1), PPP3CB(1), PTPRC(16), RELA(2), RPL13A(1), SLA(1), SP1(3), SP3(3), TGFB1(3), TNF(2), TRAF2(2), TRPV6(4), VAV1(7), VAV2(8), VAV3(6), XPO5(1)	17985403	276	71	274	104	77	94	8	61	36	0	0.41	1.00	1.00
331	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(3), CD14(1), CD19(1), CD1A(1), CD1B(3), CD1C(2), CD1D(5), CD1E(5), CD2(2), CD22(1), CD33(2), CD34(2), CD36(2), CD37(1), CD38(2), CD3E(3), CD3G(2), CD4(3), CD44(5), CD5(5), CD55(1), CD59(1), CD7(4), CD8A(2), CD8B(1), CR1(17), CR2(4), CSF1R(7), CSF2RA(6), CSF3(1), CSF3R(6), EPOR(2), FCER2(2), FLT3(7), GP5(2), GYPA(1), HLA-DRA(3), HLA-DRB1(1), IL11(2), IL11RA(2), IL1B(1), IL1R1(3), IL1R2(1), IL2RA(1), IL3(1), IL3RA(4), IL4R(1), IL5RA(1), IL6(1), IL7R(3), ITGA1(4), ITGA2(4), ITGA2B(5), ITGA3(7), ITGA4(8), ITGA5(5), ITGA6(2), ITGAM(5), ITGB3(5), KIT(6), KITLG(3), MME(5), TFRC(1), THPO(2), TNF(2), TPO(13)	16158087	217	71	214	89	62	65	9	53	26	2	0.67	1.00	1.00
332	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(2), IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(3), INPP5B(2), INPP5E(2), INPPL1(13), IPMK(1), ISYNA1(2), ITGB1BP3(3), ITPK1(2), ITPKA(1), ITPKB(6), MINPP1(3), MIOX(1), OCRL(4), PI4KA(10), PI4KB(4), PIK3C3(8), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1C(6), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLCD1(1), PLCD3(6), PLCE1(9), PLCG1(10), PLCG2(6), PLCZ1(2), PTEN(8), PTPMT1(1), SYNJ1(7), SYNJ2(15)	14671842	248	70	228	68	77	92	5	47	26	1	0.0037	1.00	1.00
333	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(2), AKT2(2), AKT3(3), BTK(2), FCER1A(1), FYN(5), GRB2(1), IL13(2), IL3(1), INPP5D(1), KRAS(17), LCP2(7), LYN(4), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(13), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), MAPK9(3), NRAS(1), PDK1(1), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCG1(10), PLCG2(6), PRKCD(3), PRKCE(6), RAC2(1), RAC3(1), RAF1(6), SOS1(4), SOS2(5), SYK(3), TNF(2), VAV1(7), VAV2(8), VAV3(6)	14261301	256	70	231	79	68	107	6	55	20	0	0.026	1.00	1.00
334	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(8), AMY2A(2), AMY2B(4), ASCC3(20), ATP13A2(7), DDX18(8), DDX19A(3), DDX23(6), DDX4(2), DDX41(7), DDX47(2), DDX50(3), DDX51(4), DDX54(6), DDX55(3), DDX56(4), DHX58(4), ENPP1(1), ENPP3(3), ENTPD7(8), EP400(19), ERCC2(4), ERCC3(3), GAA(2), GANC(4), GBA(4), GBA3(1), GBE1(4), GCK(3), GPI(4), GUSB(3), GYS1(4), GYS2(2), HK1(6), HK2(6), HK3(3), IFIH1(4), LYZL1(2), MGAM(7), MOV10L1(4), NUDT5(1), NUDT8(1), PGM1(3), PGM3(6), PYGB(4), PYGL(5), PYGM(7), RAD54B(3), RAD54L(4), RUVBL2(3), SETX(11), SI(11), SKIV2L2(3), SMARCA2(17), SMARCA5(1), TREH(4), UGDH(4), UGP2(1), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), UXS1(3)	24366227	310	69	308	114	101	106	12	52	39	0	0.36	1.00	1.00
335	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(6), ABCA10(9), ABCA12(21), ABCA13(27), ABCA2(6), ABCA3(12), ABCA4(10), ABCA5(7), ABCA6(4), ABCA7(6), ABCA8(7), ABCA9(9), ABCB1(10), ABCB10(7), ABCB11(6), ABCB4(13), ABCB5(6), ABCB6(4), ABCB7(1), ABCB8(4), ABCB9(2), ABCC1(4), ABCC10(4), ABCC11(10), ABCC12(8), ABCC2(12), ABCC3(6), ABCC4(6), ABCC5(11), ABCC6(6), ABCC8(8), ABCC9(20), ABCD1(3), ABCD2(4), ABCD3(3), ABCD4(5), ABCG1(3), ABCG2(3), ABCG4(3), ABCG5(1), ABCG8(4), CFTR(3), TAP1(3), TAP2(7)	23485351	314	69	309	116	95	106	12	64	37	0	0.19	1.00	1.00
336	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(2), AKT2(2), AKT3(3), BCL10(1), BLNK(2), BTK(2), CARD11(12), CD19(1), CD22(1), CD72(1), CD79A(6), CD81(3), CR2(4), FCGR2B(1), GSK3B(2), IFITM1(1), IKBKB(3), INPP5D(1), JUN(2), KRAS(17), LILRB3(2), LYN(4), MALT1(5), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NFKB1(5), NFKB2(3), NFKBIB(4), NRAS(1), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLCG2(6), PPP3CA(3), PPP3CB(1), PPP3R2(1), PTPN6(3), RAC2(1), RAC3(1), RASGRP3(2), SYK(3), VAV1(7), VAV2(8), VAV3(6)	14750718	244	68	218	86	68	102	6	44	24	0	0.12	1.00	1.00
337	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(20), AXIN1(7), CCND1(1), CCND2(1), CCND3(2), CSNK1E(6), CTNNB1(11), DVL1(4), DVL2(3), DVL3(5), FBXW2(2), FZD1(8), FZD10(8), FZD2(3), FZD3(4), FZD5(1), FZD6(8), FZD7(2), FZD8(4), GSK3B(2), JUN(2), LDLR(4), MAPK10(3), MAPK9(3), PAFAH1B1(3), PLAU(2), PPP2R5C(1), PPP2R5E(4), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCI(6), PRKCQ(2), PRKD1(6), RHOA(8), SFRP4(2), TCF7(2), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(5), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2)	11801751	203	68	195	83	68	44	8	50	30	3	0.58	1.00	1.00
338	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ACTB(4), ACTG1(2), ARHGEF2(5), CD14(1), CDC42(1), CDH1(14), CLDN1(1), CTNNB1(11), CTTN(2), FYN(5), HCLS1(1), ITGB1(4), KRT18(3), LY96(1), NCK1(3), NCK2(2), NCL(7), OCLN(1), RHOA(8), ROCK1(7), ROCK2(3), TLR4(13), TLR5(4), TUBA1B(1), TUBA1C(2), TUBA3C(6), TUBA3D(5), TUBA3E(5), TUBA8(3), TUBAL3(3), TUBB1(4), TUBB2A(2), TUBB2C(2), TUBB3(8), TUBB4(1), TUBB4Q(2), TUBB6(5), TUBB8(2), WASL(1), YWHAQ(2), YWHAZ(1)	10418350	160	67	151	64	44	52	7	44	13	0	0.60	1.00	1.00
339	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ACTB(4), ACTG1(2), ARHGEF2(5), CD14(1), CDC42(1), CDH1(14), CLDN1(1), CTNNB1(11), CTTN(2), FYN(5), HCLS1(1), ITGB1(4), KRT18(3), LY96(1), NCK1(3), NCK2(2), NCL(7), OCLN(1), RHOA(8), ROCK1(7), ROCK2(3), TLR4(13), TLR5(4), TUBA1B(1), TUBA1C(2), TUBA3C(6), TUBA3D(5), TUBA3E(5), TUBA8(3), TUBAL3(3), TUBB1(4), TUBB2A(2), TUBB2C(2), TUBB3(8), TUBB4(1), TUBB4Q(2), TUBB6(5), TUBB8(2), WASL(1), YWHAQ(2), YWHAZ(1)	10418350	160	67	151	64	44	52	7	44	13	0	0.60	1.00	1.00
340	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(2), AKT1(2), AKT2(2), AKT3(3), ANGPTL2(4), ARHGAP4(2), ARHGEF11(12), BTK(2), CDC42(1), CFL1(1), GDI1(1), INPPL1(13), ITPR1(17), ITPR2(18), ITPR3(16), LIMK1(4), MYLK(9), MYLK2(3), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PDK1(1), PIK3CA(33), PIK3CD(8), PIK3CG(10), PIK3R1(7), PITX2(2), PPP1R13B(6), PTEN(8), RACGAP1(2), RHO(2), ROCK1(7), ROCK2(3), SAG(1), WASF1(4), WASL(1)	13960035	227	67	211	72	77	76	14	35	25	0	0.041	1.00	1.00
341	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(2), CCKBR(4), CCR2(3), CCR3(4), CCR5(1), CELSR1(14), CELSR2(18), CELSR3(15), CHRM2(7), CHRM3(6), CIDEB(1), DRD4(1), EDNRA(3), EMR2(3), EMR3(4), F2R(2), FSHR(17), GNRHR(3), GPR116(14), GPR132(1), GPR133(8), GPR135(6), GPR143(1), GPR17(1), GPR55(5), GPR56(1), GPR61(3), GPR84(1), GRM1(17), GRPR(3), HRH4(1), LGR6(4), LPHN2(11), LPHN3(11), LTB4R2(3), NTSR1(4), OR2M4(1), OR8G2(5), P2RY13(4), PTGFR(3), SMO(6), SSTR2(2), TAAR5(3), TSHR(8), VN1R1(3)	13068214	238	66	234	68	70	73	10	69	16	0	0.0074	1.00	1.00
342	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(5), CPEB1(2), EGFR(10), ERBB2(6), ERBB4(18), ETS1(4), ETS2(1), ETV6(3), ETV7(1), FMN2(15), GRB2(1), KRAS(17), MAP2K1(4), MAPK1(2), MAPK3(1), NOTCH1(15), NOTCH2(16), NOTCH3(10), NOTCH4(7), PIWIL1(6), PIWIL2(7), PIWIL3(2), PIWIL4(2), RAF1(6), SOS1(4), SOS2(5), SPIRE1(2), SPIRE2(2)	10250243	174	66	159	68	50	55	7	43	19	0	0.61	1.00	1.00
343	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(2), AKT2(2), AKT3(3), BAD(1), CASP9(1), CDC42(1), KDR(7), KRAS(17), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK3(3), NFAT5(5), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NOS3(3), NRAS(1), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCG1(10), PLCG2(6), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKCG(4), PTGS2(2), PTK2(7), PXN(2), RAC2(1), RAC3(1), RAF1(6), SH2D2A(2), SHC2(2), SPHK1(5)	14177482	237	66	211	74	66	97	11	43	20	0	0.017	1.00	1.00
344	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(2), BDKRB2(3), CALM1(1), CALM2(2), CALM3(1), CAV1(2), CHRM1(3), CHRNA1(3), FLT1(6), FLT4(8), KDR(7), NOS3(3), PDE2A(6), PDE3A(8), PDE3B(10), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PRKG1(6), PRKG2(6), RYR2(43), SLC7A1(2)	8100208	138	65	138	54	37	51	5	39	6	0	0.37	1.00	1.00
345	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(2), APOA1(2), CD36(2), CITED2(1), CPT1B(4), CREBBP(13), DUSP1(1), DUT(1), EHHADH(2), EP300(15), HSD17B4(2), HSPA1A(1), JUN(2), LPL(2), MAPK1(2), MAPK3(1), ME1(3), NCOA1(11), NCOR1(14), NCOR2(15), NR0B2(2), NR1H3(2), NR2F1(4), NRIP1(7), PDGFA(1), PIK3CA(33), PIK3R1(7), PPARA(3), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PTGS2(2), RB1(8), RELA(2), RXRA(3), SP1(3), SRA1(1), STAT5A(1), STAT5B(4), TNF(2)	12490727	196	65	181	56	39	77	9	42	29	0	0.019	1.00	1.00
346	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(2), AKT2(2), AKT3(3), BAD(1), BCL2(1), BCR(7), BLNK(2), BTK(2), CD19(1), CD22(1), CD81(3), CR2(4), CSK(3), DAG1(7), FLOT1(1), FLOT2(3), GRB2(1), GSK3A(1), GSK3B(2), INPP5D(1), ITPR1(17), ITPR2(18), ITPR3(16), LYN(4), MAP4K1(2), MAPK1(2), MAPK3(1), NFATC1(9), NFATC2(8), NR0B2(2), PDK1(1), PIK3CA(33), PIK3CD(8), PIK3R1(7), PLCG2(6), PPP1R13B(6), PPP3CA(3), PPP3CB(1), PTPRC(16), RAF1(6), SHC1(3), SOS1(4), SOS2(5), SYK(3), VAV1(7)	14708142	236	65	219	77	70	86	9	44	27	0	0.058	1.00	1.00
347	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(2), AKT2(2), AKT3(3), BRD4(5), CAP1(2), CBL(2), CDC42(1), CDKN2A(4), F2RL2(1), FLOT1(1), FLOT2(3), GRB2(1), GSK3A(1), GSK3B(2), IGFBP1(2), INPPL1(13), IRS1(7), IRS2(3), IRS4(11), LNPEP(9), MAPK1(2), MAPK3(1), PARD3(8), PDK1(1), PIK3CA(33), PIK3CD(8), PIK3R1(7), PPYR1(7), PTEN(8), RAF1(6), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KB1(3), SERPINB6(3), SHC1(3), SLC2A4(1), SORBS1(7), SOS1(4), SOS2(5), YWHAG(1), YWHAH(1), YWHAQ(2), YWHAZ(1)	11726772	201	65	184	63	71	74	5	28	23	0	0.044	1.00	1.00
348	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(2), AKT2(2), AKT3(3), BCR(7), BTK(2), CD19(1), CDKN2A(4), DAPP1(1), FLOT1(1), FLOT2(3), GAB1(1), ITPR1(17), ITPR2(18), ITPR3(16), LYN(4), NR0B2(2), PDK1(1), PHF11(2), PIK3CA(33), PITX2(2), PLCG2(6), PPP1R13B(6), PREX1(9), PTEN(8), PTPRC(16), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KB1(3), SAG(1), SYK(3), TEC(3), VAV1(7)	11020093	198	65	183	67	61	66	9	41	21	0	0.15	1.00	1.00
349	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(2), AK3(4), CAD(7), CANT1(4), CDA(2), CTPS(2), CTPS2(2), DCK(1), DCTD(1), DHODH(1), DPYD(13), DPYS(2), DTYMK(1), DUT(1), ENTPD1(3), ENTPD3(3), ENTPD4(6), ENTPD6(1), ENTPD8(4), NME6(3), NME7(1), NT5C(1), NT5C1A(1), NT5C1B(4), NT5C2(5), NUDT2(2), PNPT1(3), POLA1(4), POLA2(2), POLD1(7), POLD3(2), POLE(14), POLE2(2), POLE3(1), POLE4(1), POLR1A(8), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(6), POLR3G(1), POLR3K(1), PRIM1(1), PRIM2(3), RRM1(4), RRM2(2), RRM2B(2), TK1(2), TK2(3), TXNRD1(5), TXNRD2(3), TYMS(1), UCK1(2), UCK2(1), UMPS(1), UPB1(2), UPP1(1), UPP2(5), UPRT(1)	16087881	201	64	201	70	64	64	10	39	24	0	0.19	1.00	1.00
350	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(1), AGT(2), AKT1(2), CALM1(1), CALM2(2), CALM3(1), CALR(4), CAMK1(1), CAMK1G(3), CAMK4(4), CREBBP(13), EDN1(3), ELSPBP1(1), F2(4), FGF2(2), GATA4(3), GSK3B(2), HAND1(3), HAND2(3), IGF1(2), LIF(2), MAP2K1(4), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(4), MEF2C(2), MYH2(14), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NKX2-5(2), NPPA(1), PIK3CA(33), PIK3R1(7), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RAF1(6), RPS6KB1(3)	9997336	189	64	175	61	48	75	10	33	23	0	0.053	1.00	1.00
351	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(2), APC(20), AR(8), ASAH1(2), BRAF(5), CAMP(1), CCL15(1), DAG1(7), EGFR(10), GNA11(4), GNA15(2), GNAI1(1), GNAQ(1), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), KCNJ3(6), KCNJ5(2), MAPK1(2), MAPK10(3), MAPK14(1), PHKA2(7), PIK3CA(33), PIK3CD(8), PIK3R1(7), PITX2(2), PTX3(1), RAF1(6)	10597552	200	63	184	65	59	64	14	40	21	2	0.086	1.00	1.00
352	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(2), AKT1(2), ANGPTL2(4), DAG1(7), DGKA(3), ETFA(1), GCA(3), ITGA9(9), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), MAP2K1(4), MAPK1(2), MAPK3(1), NR1I3(3), PAK1(4), PDE3A(8), PDE3B(10), PI3(2), PIK3C2G(3), PIK3CA(33), PIK3CD(8), PIK3R1(7), RIPK3(2), SGCB(2), VASP(3)	9723880	181	63	166	49	50	64	13	33	20	1	0.0073	1.00	1.00
353	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(6), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH3A1(5), ALDH3B2(4), AOC2(4), AOC3(3), AOX1(3), CARM1(2), COMT(3), DBH(2), DCT(7), DDC(3), ESCO2(2), FAH(2), GOT1(2), GOT2(3), GSTZ1(3), HGD(2), HPD(1), LCMT1(1), LCMT2(7), MAOA(1), MAOB(3), METTL6(1), MYST3(11), MYST4(15), NAT6(2), PNMT(3), PNPLA3(2), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), SH3GLB1(1), TAT(1), TH(1), TPO(13), TYR(5), TYRP1(5), WBSCR22(2)	11774058	174	62	173	50	49	49	5	48	21	2	0.047	1.00	1.00
354	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	BRAF(5), CREB1(4), DAXX(3), ELK1(2), GRB2(1), IKBKB(3), JUN(2), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K5(1), MAP2K6(2), MAP2K7(13), MAP3K1(8), MAP3K10(6), MAP3K11(3), MAP3K12(4), MAP3K13(5), MAP3K14(3), MAP3K2(2), MAP3K3(2), MAP3K4(10), MAP3K5(3), MAP3K6(5), MAP3K7(7), MAP3K8(1), MAP3K9(5), MAP4K1(2), MAP4K2(4), MAP4K3(2), MAP4K4(5), MAP4K5(4), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(4), MAPK6(1), MAPK7(8), MAPK8(4), MAPK9(3), MAPKAPK3(3), MAPKAPK5(2), MAX(1), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), MKNK1(1), NFKB1(5), PAK1(4), PAK2(5), RAF1(6), RELA(2), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA4(2), RPS6KB1(3), RPS6KB2(3), SHC1(3), SP1(3), STAT1(6), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TRAF2(2)	18866138	249	62	247	86	88	73	8	44	36	0	0.21	1.00	1.00
355	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(2), AKT2(2), AKT3(3), BRAF(5), EIF4B(2), EIF4EBP1(1), HIF1A(2), IGF1(2), MAPK1(2), MAPK3(1), PDPK1(1), PIK3CA(33), PIK3CB(6), PIK3CD(8), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(2), PIK3R5(5), PRKAA1(1), PRKAA2(3), RHEB(1), RICTOR(8), RPS6(1), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA6(7), RPS6KB1(3), RPS6KB2(3), TSC1(4), TSC2(4), ULK1(11), ULK2(4), ULK3(2), VEGFC(3)	10507417	167	61	152	62	56	61	9	28	13	0	0.35	1.00	1.00
356	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(1), CRK(1), DOCK1(12), ELK1(2), GAB1(1), GRB2(1), HGF(11), ITGA1(4), ITGB1(4), JUN(2), MAP2K1(4), MAP2K2(1), MAP4K1(2), MAPK1(2), MAPK3(1), MAPK8(4), MET(4), PAK1(4), PIK3CA(33), PIK3R1(7), PTEN(8), PTK2(7), PTK2B(8), PTPN11(4), PXN(2), RAF1(6), RAP1A(2), RAP1B(4), RASA1(10), SOS1(4), STAT3(7)	8802381	163	61	145	52	35	61	8	33	25	1	0.14	1.00	1.00
357	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(5), AR(8), ESR1(5), ESR2(6), HNF4A(5), NR0B1(2), NR1D1(3), NR1D2(4), NR1H2(4), NR1H3(2), NR1I2(3), NR1I3(3), NR2C2(3), NR2E1(1), NR2F1(4), NR2F2(3), NR2F6(2), NR3C1(5), NR4A1(2), NR4A2(6), NR5A1(5), NR5A2(1), PGR(7), PPARA(3), PPARD(5), PPARG(1), RARA(2), RARB(5), ROR1(6), RORA(2), RORC(3), RXRA(3), RXRG(3), THRA(4), THRB(5), VDR(5)	8268927	136	61	135	51	45	31	7	41	12	0	0.46	1.00	1.00
358	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(2), BMP4(6), BMP5(6), BMP6(5), BMP7(2), BMP8A(1), BMP8B(2), BTRC(3), CSNK1A1L(3), CSNK1D(2), CSNK1E(6), CSNK1G1(2), CSNK1G2(2), CSNK1G3(4), DHH(3), FBXW11(5), GLI1(9), GLI2(9), GLI3(16), GSK3B(2), HHIP(6), IHH(2), LRP2(36), PRKACA(1), PRKACB(2), PRKACG(3), PRKX(2), PTCH1(12), PTCH2(4), SMO(6), STK36(9), SUFU(3), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(5), WNT3A(1), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2)	11881399	218	60	215	77	84	58	8	43	25	0	0.21	1.00	1.00
359	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(3), INPPL1(13), ITPKA(1), ITPKB(6), MIOX(1), OCRL(4), PIK3C2A(4), PIK3C2B(12), PIK3C2G(3), PIK3CA(33), PIK3CB(6), PIK3CG(10), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), PLCD1(1), PLCG1(10), PLCG2(6)	8915991	156	60	140	42	43	63	5	31	13	1	0.026	1.00	1.00
360	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(2), AKT2(2), AKT3(3), BAD(1), BCR(7), BLNK(2), BTK(2), CD19(1), CSK(3), DAG1(7), EPHB2(11), GRB2(1), ITPKA(1), ITPKB(6), LYN(4), MAP2K1(4), MAP2K2(1), MAPK1(2), NFAT5(5), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PI3(2), PIK3CA(33), PIK3CD(8), PIK3R1(7), PLCG2(6), PPP1R13B(6), RAF1(6), SERPINA4(2), SHC1(3), SOS1(4), SOS2(5), SYK(3), VAV1(7)	10423303	175	60	157	49	46	68	5	29	26	1	0.025	1.00	1.00
361	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(3), ADCY4(5), ADCY6(5), ADCY8(12), CACNA1A(11), CACNA1B(14), GNAS(14), GNAT3(2), GNB1(1), GNB3(1), GRM4(5), ITPR3(16), KCNB1(5), PDE1A(3), PLCB2(4), PRKACA(1), PRKACB(2), PRKACG(3), PRKX(2), SCNN1A(2), SCNN1B(5), SCNN1G(4), TAS1R1(5), TAS1R2(3), TAS1R3(5), TAS2R1(2), TAS2R10(2), TAS2R13(2), TAS2R16(3), TAS2R3(2), TAS2R38(3), TAS2R39(3), TAS2R4(2), TAS2R40(3), TAS2R41(1), TAS2R43(1), TAS2R46(1), TAS2R50(1), TAS2R60(3), TAS2R7(2), TAS2R8(1), TAS2R9(2), TRPM5(2)	11246597	169	59	167	79	57	57	7	38	10	0	0.85	1.00	1.00
362	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(2), CDC40(6), CLK2(6), CLK3(5), CLK4(3), COL2A1(8), CPSF1(11), CPSF2(2), CPSF3(2), CPSF4(2), CSTF1(4), CSTF2(4), CSTF2T(2), CSTF3(4), DDIT3(3), DDX1(3), DDX20(3), DHX15(8), DHX16(5), DHX38(7), DHX8(5), DHX9(1), DICER1(5), DNAJC8(1), GIPC1(2), METTL3(1), NCBP1(4), NUDT21(1), NXF1(3), PABPN1(2), PAPOLA(2), PHF5A(2), POLR2A(9), PPM1G(3), PRPF3(2), PRPF4(4), PRPF4B(9), PRPF8(10), PSKH1(4), PTBP1(4), PTBP2(1), RBM5(3), RNGTT(1), RNMT(3), RNPS1(1), SF3A1(2), SF3A2(1), SF3A3(2), SF3B1(4), SF3B2(6), SF3B4(3), SF4(6), SFRS12(3), SFRS14(6), SFRS16(2), SFRS4(3), SFRS5(4), SFRS6(5), SFRS7(2), SFRS8(7), SFRS9(1), SNRPA(5), SNRPA1(2), SNRPB(1), SNRPD1(3), SNRPD2(2), SNRPD3(1), SNRPE(1), SNRPG(1), SNRPN(4), SPOP(2), SRPK1(2), SRPK2(5), SRRM1(3), SUPT5H(7), U2AF1(2), U2AF2(3), XRN2(12)	20867834	286	59	285	92	105	80	18	56	27	0	0.20	1.00	1.00
363	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(2), AKT3(3), ANKRD6(3), APC(20), AXIN1(7), AXIN2(3), CER1(3), CTNNB1(11), DACT1(4), DKK1(5), DKK2(2), DKK3(1), DKK4(2), DVL1(4), GSK3A(1), GSK3B(2), LRP1(23), MVP(4), NKD1(6), NKD2(1), PIN1(1), PSEN1(1), PTPRA(5), SENP2(3), SFRP1(3), TSHB(1), WIF1(2)	7982080	125	59	123	49	42	39	2	25	15	2	0.59	1.00	1.00
364	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(1), ACADL(2), ACADM(1), ACOX1(2), ACOX2(4), ACOX3(5), ACSL1(2), ACSL3(6), ACSL4(3), ACSL5(2), ACSL6(5), ADIPOQ(2), ANGPTL4(2), APOA1(2), APOA5(5), AQP7(2), CD36(2), CPT1A(4), CPT1B(4), CPT1C(4), CPT2(4), CYP27A1(1), CYP4A11(1), CYP4A22(1), CYP7A1(3), CYP8B1(4), DBI(1), EHHADH(2), FABP2(1), FABP3(1), FABP5(2), FABP6(3), FABP7(1), FADS2(4), GK(2), GK2(1), HMGCS2(1), ILK(2), LPL(2), ME1(3), MMP1(2), NR1H3(2), OLR1(2), PCK1(4), PCK2(6), PDPK1(1), PLTP(3), PPARA(3), PPARD(5), PPARG(1), RXRA(3), RXRG(3), SCD(4), SCP2(3), SLC27A1(3), SLC27A2(2), SLC27A4(3), SLC27A5(6), SLC27A6(4), SORBS1(7), UBC(3)	12968549	170	58	170	47	62	40	11	41	16	0	0.015	1.00	1.00
365	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(4), ADAM17(3), ATP6AP1(4), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), CASP3(1), CCL5(1), CDC42(1), CSK(3), EGFR(10), GIT1(2), IGSF5(2), IKBKB(3), IL8(1), JAM3(3), JUN(2), LYN(4), MAP2K4(5), MAP3K14(3), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK8(4), MAPK9(3), MET(4), NFKB1(5), NFKB2(3), NOD1(7), PAK1(4), PLCG1(10), PLCG2(6), PTPN11(4), PTPRZ1(15), RELA(2), TCIRG1(4), TJP1(6)	13905064	173	58	172	77	43	57	6	47	20	0	0.88	1.00	1.00
366	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(2), ASAH1(2), BRAF(5), CAMP(1), CREB1(4), CREB3(3), CREB5(2), CREBBP(13), DAG1(7), EGR1(3), EGR2(3), EGR3(1), EGR4(4), ELK1(2), FRS2(4), GNAQ(1), JUN(2), MAP1B(9), MAP2K4(5), MAP2K7(13), MAPK1(2), MAPK10(3), MAPK3(1), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3), NTRK1(4), OPN1LW(4), PIK3C2G(3), PIK3CA(33), PIK3CD(8), PIK3R1(7), PTPN11(4), RPS6KA3(1), SHC1(3), TERF2IP(3), TH(1)	10136109	181	58	166	64	56	63	5	32	25	0	0.20	1.00	1.00
367	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(13), ACSL1(2), ACSL3(6), ACSL4(3), ACSL5(2), ACSL6(5), ADIPOQ(2), ADIPOR1(2), ADIPOR2(2), AGRP(1), AKT1(2), AKT2(2), AKT3(3), CAMKK1(4), CAMKK2(1), CD36(2), CPT1A(4), CPT1B(4), CPT1C(4), CPT2(4), IKBKB(3), IRS1(7), IRS2(3), IRS4(11), JAK1(4), JAK2(8), JAK3(3), LEPR(8), MAPK10(3), MAPK8(4), MAPK9(3), NFKB1(5), NFKB2(3), NFKBIB(4), NPY(1), PCK1(4), PCK2(6), POMC(5), PPARA(3), PPARGC1A(6), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2), PRKAG3(3), PRKCQ(2), PTPN11(4), RELA(2), RXRA(3), RXRG(3), SLC2A1(3), SLC2A4(1), SOCS3(3), STAT3(7), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF2(2), TYK2(6)	16348424	217	57	217	88	73	55	6	55	27	1	0.68	1.00	1.00
368	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(4), CAD(7), CANT1(4), CDA(2), CTPS(2), CTPS2(2), DCK(1), DCTD(1), DHODH(1), DPYD(13), DPYS(2), DTYMK(1), DUT(1), ENTPD1(3), NT5C(1), NUDT2(2), POLD1(7), POLE(14), POLG(4), POLL(1), POLQ(14), POLR1B(2), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(9), RRM1(4), RRM2(2), TK1(2), TK2(3), TXNRD1(5), TYMS(1), UCK1(2), UCK2(1), UMPS(1), UNG(1), UPB1(2), UPP1(1)	11319087	140	57	140	59	41	45	7	30	17	0	0.68	1.00	1.00
369	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(4), APC(20), AXIN1(7), BMP10(2), BMP2(2), BMP4(6), BMP5(6), BMP7(2), BMPR1A(1), BMPR2(10), CHRD(1), CTNNB1(11), DVL1(4), FZD1(8), GATA4(3), GSK3B(2), MAP3K7(7), MEF2C(2), MYL2(1), NKX2-5(2), NPPA(1), NPPB(1), RFC1(1), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TGFBR2(6), TGFBR3(2), WNT1(3)	7170285	130	56	126	45	35	33	5	34	19	4	0.55	1.00	1.00
370	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(17), BMPR1B(3), CCND2(1), DMC1(1), EGR1(3), ESR2(6), FSHR(17), GJA4(4), INHA(2), LHCGR(7), MLH1(3), MSH5(5), NCOR1(14), NR5A1(5), NRIP1(7), PGR(7), PRLR(2), PTGER2(2), SMPD1(4), VDR(5), ZP2(5)	6924628	120	56	116	35	33	42	5	26	13	1	0.083	1.00	1.00
371	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(20), AXIN1(7), CREBBP(13), CTNNB1(11), DVL1(4), EP300(15), FZD1(8), GSK3B(2), HDAC1(2), LDB1(5), LEF1(4), PITX2(2), TRRAP(27), WNT1(3)	6530618	123	56	121	51	43	27	3	24	24	2	0.77	1.00	1.00
372	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CDK5(2), CDK5R1(1), CFL1(1), CHN1(4), LIMK1(4), MAP3K1(8), MYL2(1), MYLK(9), NCF2(1), PAK1(4), PDGFRA(4), PIK3CA(33), PIK3R1(7), PLD1(7), PPP1R12B(7), RALBP1(7), RPS6KB1(3), TRIO(22), VAV1(7), WASF1(4)	6929746	136	56	121	49	40	52	5	24	14	1	0.36	1.00	1.00
373	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(2), AKT3(3), ASAH1(2), BRAF(5), DAG1(7), DRD2(6), EGFR(10), EPHB2(11), GRB2(1), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), KCNJ3(6), KCNJ5(2), MAPK1(2), PI3(2), PIK3CB(6), PITX2(2), PLCB1(12), PLCB2(4), PLCB3(8), PLCB4(8), RAF1(6), RGS20(2), SHC1(3), SOS1(4), SOS2(5), STAT3(7), TERF2IP(3)	11634546	189	56	186	70	63	61	6	36	22	1	0.38	1.00	1.00
374	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT1(2), AKT2(2), AKT3(3), BAD(1), BTK(2), CDKN2A(4), DAPP1(1), GRB2(1), GSK3A(1), GSK3B(2), IARS(7), IGFBP1(2), INPP5D(1), PDK1(1), PIK3CA(33), PPP1R13B(6), PTEN(8), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KB1(3), SHC1(3), SOS1(4), SOS2(5), TEC(3), YWHAG(1), YWHAH(1), YWHAQ(2), YWHAZ(1)	7139564	115	56	101	37	26	51	3	22	13	0	0.18	1.00	1.00
375	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), AGK(2), AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPAT6(2), AKR1B1(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), CEL(6), DAK(3), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKI(5), DGKQ(2), DGKZ(1), GK(2), GK2(1), GLB1(3), GPAM(5), LCT(11), LIPA(2), LIPC(2), LIPF(1), LIPG(3), LPL(2), PNLIP(2), PNLIPRP1(3), PNLIPRP2(2), PNPLA3(2), PPAP2C(5)	11648621	149	55	148	55	37	56	3	35	18	0	0.27	1.00	1.00
376	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(4), ALPL(3), ALPP(5), ALPPL2(4), ASCC3(20), ATP13A2(7), DDX18(8), DDX19A(3), DDX23(6), DDX4(2), DDX41(7), DDX47(2), DDX50(3), DDX51(4), DDX54(6), DDX55(3), DDX56(4), DHX58(4), ENTPD7(8), EP400(19), ERCC2(4), ERCC3(3), FPGS(1), GGH(1), IFIH1(4), MOV10L1(4), NUDT5(1), NUDT8(1), QDPR(3), RAD54B(3), RAD54L(4), RUVBL2(3), SETX(11), SKIV2L2(3), SMARCA2(17), SMARCA5(1), SPR(2)	12409047	188	55	185	69	74	53	7	32	22	0	0.43	1.00	1.00
377	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	DUSP1(1), GORASP1(2), MAP2K4(5), MAP2K7(13), MAPK1(2), MAPK10(3), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(9), MAPK9(3), MAPKAPK5(2), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PIK3CA(33), PIK3CD(8), PIK3R1(7), TRAF2(2), TRAF3(2), TRAF6(4)	6595701	124	55	109	33	40	44	6	19	15	0	0.014	1.00	1.00
378	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(2), APAF1(2), BAG4(2), BCL2(1), BID(1), BIRC2(2), BIRC3(4), CASP2(3), CASP3(1), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), DAXX(3), DFFA(2), DFFB(2), GSN(5), LMNA(5), LMNB1(2), LMNB2(3), MAP2K7(13), MAP3K1(8), MAP3K14(3), MAP3K5(3), MAPK8(4), MDM2(3), NFKB1(5), NUMA1(14), PAK2(5), PRKCD(3), PRKDC(22), PSEN1(1), PSEN2(2), PTK2(7), RASA1(10), RB1(8), RELA(2), SPTAN1(13), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF1(2), TRAF2(2)	13784703	187	54	184	59	57	58	9	33	29	1	0.10	1.00	1.00
379	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(4), AASS(2), ACAT1(3), ACAT2(3), AKR1B10(1), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), BBOX1(1), DLST(1), DOT1L(9), EHHADH(2), EHMT1(7), EHMT2(4), GCDH(3), HADH(2), HADHA(2), HSD17B4(2), HSD3B7(3), NSD1(13), OGDH(8), OGDHL(3), PIPOX(3), PLOD1(6), PLOD2(3), PLOD3(4), RDH11(1), RDH12(1), SETD1A(7), SETDB1(12), SHMT1(1), SHMT2(4), SPCS3(1), SUV39H1(4), SUV39H2(1), TMLHE(4)	11447372	149	54	146	56	46	49	6	27	21	0	0.37	1.00	1.00
380	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(3), AKT1(2), APC(20), ASAH1(2), CAMP(1), DAG1(7), DLG4(5), EPHB2(11), GNAI1(1), GNAQ(1), ITPR1(17), ITPR2(18), ITPR3(16), KCNJ3(6), KCNJ5(2), MAPK1(2), PITX2(2), PTX3(1), RHO(2), RYR1(33)	9135416	152	54	148	62	63	33	8	27	20	1	0.56	1.00	1.00
381	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(2), CSK(3), CTLA4(3), DAG1(7), DTYMK(1), EPHB2(11), FBXW7(11), GRAP2(1), GRB2(1), ITK(4), ITPKA(1), ITPKB(6), LCK(1), LCP2(7), MAPK1(2), NCK1(3), NFAT5(5), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PLCG1(10), PTPRC(16), RAF1(6), RASGRP1(4), RASGRP2(4), RASGRP3(2), RASGRP4(3), SOS1(4), SOS2(5), VAV1(7), ZAP70(4)	11069594	172	54	165	63	48	46	5	43	29	1	0.57	1.00	1.00
382	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(6), AGMAT(2), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH4A1(2), ALDH9A1(4), AMD1(2), AOC2(4), AOC3(3), ARG1(2), ASL(5), CKB(1), CKMT1A(2), CKMT1B(3), CKMT2(6), CPS1(15), DAO(5), GATM(2), GLUD1(4), GOT1(2), GOT2(3), MAOA(1), MAOB(3), NOS1(16), NOS3(3), ODC1(3), OTC(2), P4HA1(1), P4HA2(6), P4HA3(1), P4HB(4), PYCR1(2), RARS(2), SMS(2)	8734139	147	53	146	41	51	39	5	37	14	1	0.038	1.00	1.00
383	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(11), AKT1(2), ASAH1(2), GNAI1(1), GNB1(1), GNGT1(3), ITGAV(4), ITGB3(5), MAPK1(2), MAPK3(1), PDGFA(1), PDGFRA(4), PIK3CA(33), PIK3R1(7), PLCB1(12), PTK2(7), SMPD1(4), SPHK1(5)	5427976	105	53	91	37	28	46	8	11	12	0	0.21	1.00	1.00
384	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(4), B3GALNT1(2), B3GALT1(2), B3GALT2(5), B3GALT4(3), B3GALT5(1), B3GNT1(1), B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(1), B4GALNT1(2), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), B4GALT6(2), FUT1(2), FUT4(1), FUT7(1), FUT9(3), GCNT2(2), PIGA(2), PIGB(4), PIGC(2), PIGG(5), PIGK(1), PIGL(1), PIGM(4), PIGN(3), PIGO(1), PIGQ(2), PIGS(1), PIGT(3), PIGV(3), PIGX(2), PIGZ(2), ST3GAL1(3), ST3GAL2(4), ST3GAL3(2), ST3GAL4(3), ST3GAL5(1), ST3GAL6(2), ST6GALNAC3(3), ST6GALNAC4(2), ST6GALNAC5(1), ST6GALNAC6(3), ST8SIA1(4), ST8SIA5(2)	9591689	114	53	113	45	40	33	5	29	6	1	0.49	1.00	1.00
385	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(6), DIAPH1(4), FYN(5), GSN(5), ITGA1(4), ITGB1(4), MAP2K1(4), MAPK1(2), MAPK3(1), MYL2(1), MYLK(9), PIK3CA(33), PIK3R1(7), PTK2(7), PXN(2), RAF1(6), ROCK1(7), SHC1(3), TLN1(13)	7407037	123	52	108	33	27	50	8	22	15	1	0.032	1.00	1.00
386	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(6), AGXT(1), AGXT2(6), ALAS1(2), ALAS2(4), AMT(4), AOC2(4), AOC3(3), BHMT(5), CBS(3), CHDH(4), CHKA(1), CHKB(3), CPT1B(4), CTH(2), DAO(5), DLD(2), DMGDH(5), GARS(1), GATM(2), GCAT(3), GLDC(5), MAOA(1), MAOB(3), PEMT(1), PISD(4), PLCB2(4), PLCG1(10), PLCG2(6), PSPH(2), SARDH(4), SARS(4), SHMT1(1), SHMT2(4), TARS(6)	8303360	125	52	124	49	37	30	9	35	13	1	0.64	1.00	1.00
387	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(7), AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPAT6(2), CDS1(4), CDS2(1), CHAT(1), CHKA(1), CHKB(3), CHPT1(1), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKI(5), DGKQ(2), DGKZ(1), ESCO2(2), ETNK2(2), GNPAT(1), GPAM(5), GPD1(3), GPD1L(3), GPD2(3), LCAT(1), LYPLA2(1), MYST3(11), MYST4(15), NAT6(2), PCYT1A(7), PCYT1B(3), PEMT(1), PISD(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLD1(7), PLD2(11), PNPLA3(2), PPAP2C(5), PTDSS1(1), PTDSS2(2), SH3GLB1(1)	12927296	172	52	171	65	59	56	8	36	13	0	0.31	1.00	1.00
388	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(2), AKT2(2), AKT3(3), BAD(1), BCL2(1), GRB2(1), GSK3A(1), GSK3B(2), IL4R(1), IRS1(7), IRS2(3), JAK1(4), JAK3(3), MAP4K1(2), MAPK1(2), MAPK3(1), PDK1(1), PIK3CA(33), PIK3CD(8), PIK3R1(7), PPP1R13B(6), RAF1(6), SHC1(3), SOCS1(1), SOS1(4), SOS2(5)	7201323	110	52	94	31	30	48	3	19	9	1	0.051	1.00	1.00
389	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(20), AXIN1(7), BTRC(3), CCND1(1), CREBBP(13), CSNK1D(2), CSNK2A1(4), CTBP1(2), CTNNB1(11), DVL1(4), FZD1(8), GSK3B(2), HDAC1(2), MAP3K7(7), NLK(5), PPARD(5), PPP2CA(3), TLE1(3), WIF1(2), WNT1(3)	5795793	107	52	104	38	32	27	5	19	22	2	0.46	1.00	1.00
390	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), AGPAT1(1), AGPAT3(2), AGPAT4(5), AKR1B1(5), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), CEL(6), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKQ(2), DGKZ(1), GK(2), GLB1(3), LCT(11), LIPC(2), LIPF(1), LIPG(3), LPL(2), PNLIP(2), PNLIPRP1(3), PNLIPRP2(2), PPAP2C(5)	9570515	134	51	133	55	36	47	2	32	17	0	0.53	1.00	1.00
391	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(8), GABBR1(8), GPRC5A(1), GPRC5B(4), GPRC5C(3), GPRC5D(1), GRM1(17), GRM2(11), GRM3(5), GRM4(5), GRM5(14), GRM7(12), GRM8(11)	4137303	100	51	100	36	44	20	5	24	7	0	0.25	1.00	1.00
392	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(3), ACTN2(15), ACTN3(2), BCAR1(4), BCR(7), CAPN1(3), CAPNS1(1), CAPNS2(1), CAV1(2), CSK(3), FYN(5), GRB2(1), ITGA1(4), ITGB1(4), JUN(2), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MAPK8(4), PPP1R12B(7), PTK2(7), PXN(2), RAF1(6), RAP1A(2), ROCK1(7), SHC1(3), SOS1(4), TLN1(13), VCL(2), ZYX(2)	9283378	125	51	123	53	41	38	5	29	12	0	0.71	1.00	1.00
393	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(11), ARHGEF1(2), F2(4), F2R(2), GNA12(1), GNAI1(1), GNAQ(1), GNB1(1), GNGT1(3), MAP3K7(7), PIK3CA(33), PIK3R1(7), PLCB1(12), PPP1R12B(7), PTK2B(8), ROCK1(7)	5107375	107	51	93	37	28	45	4	18	12	0	0.33	1.00	1.00
394	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(23), B3GALT4(3), CDR1(4), DGKI(5), IL6ST(2), PIGK(1), RPL10(2), RPL12(1), RPL13(1), RPL13A(1), RPL14(1), RPL18A(1), RPL19(2), RPL22(10), RPL27A(1), RPL3(2), RPL31(1), RPL34(1), RPL36(1), RPL5(1), RPL6(1), RPL7A(3), RPL8(2), RPL9(2), RPLP0(3), RPLP1(1), RPS10(1), RPS11(1), RPS13(1), RPS14(2), RPS20(1), RPS23(1), RPS27A(1), RPS3(1), RPS3A(1), RPS5(2), RPS6(1), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), RPS6KA6(7), RPS6KB1(3), RPS6KB2(3), RPSA(4), SLC36A2(4), TBC1D10C(1), TSPAN9(1), UBC(3)	10384990	129	51	120	49	28	42	7	31	20	1	0.81	1.00	1.00
395	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(2), AKT2(2), AKT3(3), CISH(2), GRB2(1), IARS(7), IL13RA1(2), IL2RG(3), IL4R(1), INPP5D(1), JAK1(4), JAK2(8), JAK3(3), NR0B2(2), PI3(2), PIK3CA(33), PPP1R13B(6), RPS6KB1(3), SERPINA4(2), SHC1(3), SOS1(4), SOS2(5), TYK2(6)	7303586	105	51	90	32	19	45	4	23	13	1	0.19	1.00	1.00
396	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(6), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH3A1(5), ALDH3B2(4), AOC2(4), AOC3(3), AOX1(3), COMT(3), DBH(2), DCT(7), DDC(3), FAH(2), GOT1(2), GOT2(3), GSTZ1(3), HGD(2), HPD(1), MAOA(1), MAOB(3), PNMT(3), TAT(1), TH(1), TPO(13), TYR(5)	6275275	108	51	107	35	30	29	1	34	12	2	0.25	1.00	1.00
397	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B1(3), EIF2B3(3), EIF2B4(6), EIF2B5(4), EIF2S1(1), EIF2S2(2), EIF2S3(1), ELAVL1(3), FLT1(6), FLT4(8), HIF1A(2), KDR(7), NOS3(3), PIK3CA(33), PIK3R1(7), PLCG1(10), PTK2(7), PXN(2), SHC1(3)	6707419	111	51	95	30	32	45	7	18	9	0	0.025	1.00	1.00
398	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(9), CARM1(2), CCND1(1), CREBBP(13), EP300(15), ERCC3(3), ESR1(5), GRIP1(8), GTF2A1(2), GTF2E1(5), GTF2F1(2), HDAC1(2), HDAC2(4), HDAC3(4), HDAC4(7), HDAC5(4), HDAC6(3), MEF2C(2), NCOR2(15), NR0B1(2), NRIP1(7), PELP1(6), POLR2A(9), SRA1(1), TBP(3)	9068427	134	50	132	46	40	35	6	29	24	0	0.30	1.00	1.00
399	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(11), AKT1(2), CAMK2A(1), CAMK2B(2), CAMK2G(4), CREB1(4), GNAS(14), GRB2(1), MAPK1(2), MAPK14(1), MAPK3(1), PIK3CA(33), PIK3R1(7), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RPS6KA1(6), SOS1(4)	5741073	108	50	93	31	29	50	3	14	12	0	0.089	1.00	1.00
400	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(7), ACSS2(3), ACYP2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH3B2(4), ALDH9A1(4), ALDOB(4), ALDOC(3), BPGM(1), DLAT(6), DLD(2), ENO1(3), ENO2(1), ENO3(3), FBP1(1), FBP2(3), GALM(1), GAPDH(1), GAPDHS(2), GCK(3), GPI(4), HK1(6), HK2(6), HK3(3), LDHAL6B(2), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKL(7), PFKM(3), PFKP(8), PGAM2(2), PGAM4(1), PGK1(1), PGK2(1), PGM1(3), PGM3(6), PKLR(4), PKM2(2), TPI1(2)	11496083	167	50	166	64	51	52	7	41	16	0	0.37	1.00	1.00
401	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(2), AARS2(5), ABAT(4), ACY3(1), ADSL(4), ADSS(3), ADSSL1(7), AGXT(1), AGXT2(6), ASL(5), ASNS(4), ASRGL1(1), ASS1(6), CAD(7), CRAT(3), DARS(2), DDO(2), DLAT(6), DLD(2), GAD1(3), GAD2(4), GOT1(2), GOT2(3), GPT(1), GPT2(3), NARS(3), NARS2(1), PC(6), PDHA1(1), PDHA2(4), PDHB(2)	7476091	104	50	102	39	44	26	2	26	6	0	0.46	1.00	1.00
402	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(4), AANAT(1), ABP1(6), ACAT1(3), ACAT2(3), ACMSD(2), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), AOC2(4), AOC3(3), AOX1(3), ASMT(2), CARM1(2), CAT(4), CYP1A1(3), CYP1A2(3), CYP1B1(2), DDC(3), EHHADH(2), GCDH(3), HADH(2), HADHA(2), HSD17B4(2), INMT(1), KYNU(6), LCMT1(1), LCMT2(7), LNX1(4), MAOA(1), MAOB(3), METTL6(1), NFX1(2), OGDH(8), OGDHL(3), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), TDO2(3), TPH1(1), TPH2(4), WARS(3), WARS2(5), WBSCR22(2)	11978322	152	50	147	48	38	49	8	32	23	2	0.094	1.00	1.00
403	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(13), COL4A2(7), COL4A3(4), COL4A4(7), COL4A5(5), COL4A6(7), F10(3), F11(3), F12(2), F2(4), F2R(2), F5(9), F8(13), F9(4), FGA(5), FGB(3), FGG(2), KLKB1(4), PROC(3), PROS1(6), SERPINC1(2), SERPING1(6)	8833521	114	50	113	40	24	39	4	35	12	0	0.36	1.00	1.00
404	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(11), AKT1(2), BAD(1), BCL2(1), CSF2RB(7), IGF1(2), IGF1R(11), IL3(1), IL3RA(4), KIT(6), KITLG(3), PIK3CA(33), PIK3R1(7), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), YWHAH(1)	4336127	105	49	91	34	25	54	3	16	7	0	0.077	1.00	1.00
405	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(9), ATP4A(5), ATP4B(2), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5G3(1), ATP5J(1), ATP5J2(1), ATP5L(1), ATP6AP1(4), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), COX10(1), COX15(3), COX4I1(4), COX4I2(1), COX6B1(1), COX7A2(2), COX7C(1), LHPP(3), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA3(1), NDUFA6(1), NDUFA8(1), NDUFA9(2), NDUFAB1(1), NDUFB2(1), NDUFB7(1), NDUFB8(1), NDUFB9(1), NDUFC2(2), NDUFS1(5), NDUFS2(2), NDUFS5(1), NDUFS6(1), NDUFS7(1), NDUFS8(3), NDUFV1(1), PPA2(2), SDHA(5), SDHB(4), SDHC(1), TCIRG1(4), UQCRB(1), UQCRC1(2), UQCRC2(2), UQCRFS1(1), UQCRQ(1)	11013913	135	49	135	65	37	50	8	32	8	0	0.92	1.00	1.00
406	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(4), ADC(1), ALDH4A1(2), ALDH5A1(3), CAD(7), CPS1(15), EARS2(2), EPRS(6), GAD1(3), GAD2(4), GCLM(2), GFPT1(3), GFPT2(3), GLS(4), GLS2(5), GLUD1(4), GLUD2(7), GLUL(2), GMPS(3), GOT1(2), GOT2(3), GPT(1), GPT2(3), GSR(4), GSS(1), NADSYN1(5), NAGK(1), PPAT(1), QARS(5)	7823866	106	49	104	38	38	33	6	24	5	0	0.35	1.00	1.00
407	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(6), AGXT(1), AGXT2(6), AKR1B10(1), ALAS1(2), ALAS2(4), AMT(4), AOC2(4), AOC3(3), BHMT(5), CBS(3), CHDH(4), CHKA(1), CHKB(3), CTH(2), DAO(5), DLD(2), DMGDH(5), GARS(1), GATM(2), GCAT(3), GLDC(5), GNMT(2), HSD3B7(3), MAOA(1), MAOB(3), PEMT(1), PHGDH(1), PIPOX(3), PISD(4), PSAT1(2), PSPH(2), RDH11(1), RDH12(1), SARDH(4), SARS(4), SARS2(3), SDS(1), SHMT1(1), SHMT2(4), TARS(6), TARS2(6)	8434837	125	49	125	48	41	29	10	32	12	1	0.54	1.00	1.00
408	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(15), ACACB(13), ACAT1(3), ACAT2(3), ACOT12(4), ACSS1(7), ACSS2(3), ACYP2(1), AKR1B1(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), DLAT(6), DLD(2), GRHPR(2), HAGH(2), LDHAL6B(2), LDHB(2), LDHC(1), LDHD(2), MDH1(3), MDH2(1), ME1(3), ME2(4), ME3(5), PC(6), PCK1(4), PCK2(6), PDHA1(1), PDHA2(4), PDHB(2), PKLR(4), PKM2(2)	9230719	142	49	142	40	44	38	7	35	18	0	0.039	1.00	1.00
409	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(3), CREBBP(13), CTBP1(2), CTBP2(4), DLL1(3), DLL3(2), DLL4(1), DTX1(7), DTX2(2), DTX3L(1), DTX4(4), DVL1(4), DVL2(3), DVL3(5), EP300(15), HDAC1(2), HDAC2(4), JAG1(4), JAG2(1), MAML1(4), MAML2(7), MAML3(7), NCOR2(15), NCSTN(3), NOTCH1(15), NOTCH2(16), NOTCH3(10), NOTCH4(7), NUMB(2), NUMBL(3), PSEN1(1), PSEN2(2), PSENEN(1), PTCRA(1), RBPJ(2), RBPJL(3), RFNG(1)	13532733	180	49	176	81	63	50	7	33	27	0	0.77	1.00	1.00
410	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(1), DAXX(3), EGF(5), EGFR(10), ETS1(4), ETS2(1), HOXA7(2), IKBKB(3), JUN(2), MAP2K1(4), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP2K7(13), MAP3K1(8), MAP3K14(3), MAP3K5(3), MAPK1(2), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(4), NFKB1(5), PPP2CA(3), PRKCD(3), PRKCE(6), PRKCG(4), PRKCH(5), PRKCQ(2), RAF1(6), RELA(2), SP1(3), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF2(2)	9707027	126	49	125	50	42	35	2	30	17	0	0.49	1.00	1.00
411	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(8), AMY2A(2), AMY2B(4), ENPP1(1), ENPP3(3), GAA(2), GANAB(3), GBA3(1), GBE1(4), GCK(3), GPI(4), GUSB(3), GYS1(4), GYS2(2), HK1(6), HK2(6), HK3(3), MGAM(7), PGM1(3), PGM3(6), PYGB(4), PYGL(5), PYGM(7), SI(11), UCHL1(2), UCHL3(3), UGDH(4), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2B15(1), UGT2B4(2), UXS1(3)	11343467	122	49	122	43	35	45	4	19	19	0	0.27	1.00	1.00
412	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(2), EIF4A1(2), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4G1(10), EIF4G2(1), EIF4G3(5), GHR(5), IRS1(7), MAPK1(2), MAPK14(1), MAPK3(1), MKNK1(1), PABPC1(3), PDPK1(1), PIK3CA(33), PIK3R1(7), PTEN(8), RPS6KB1(3)	5573230	97	48	83	32	19	44	6	17	11	0	0.30	1.00	1.00
413	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(3), ALOX12(4), ALOX15(2), ALOX5(6), CBR1(1), CBR3(3), CYP4F2(4), CYP4F3(3), EPX(4), GGT1(8), LPO(2), LTA4H(4), MPO(5), PLA2G1B(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PRDX6(1), PTGES2(4), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(2), TPO(13)	5493529	96	48	94	31	35	23	4	25	9	0	0.23	1.00	1.00
414	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(6), AKT1(2), AKT2(2), AKT3(3), DAG1(7), GNAQ(1), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PDK1(1), PHKA2(7), PIK3CB(6), PITX2(2), PLD1(7), PLD2(11), PLD3(5), VN1R1(3)	8914753	139	48	139	50	44	43	9	30	12	1	0.31	1.00	1.00
415	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(5), EEF1B2(1), EEF1D(4), EEF1G(3), EEF2(3), EEF2K(8), EIF1AX(1), EIF1AY(1), EIF2AK1(4), EIF2AK2(2), EIF2AK3(8), EIF2B1(3), EIF2B3(3), EIF2B4(6), EIF2B5(4), EIF2S1(1), EIF2S2(2), EIF2S3(1), EIF4A1(2), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4EBP2(1), EIF4G1(10), EIF4G3(5), EIF5(3), EIF5A(3), EIF5B(6), ETF1(3), GSPT2(1), KIAA0664(9), PABPC1(3), PABPC3(5), PAIP1(1), SLC35A4(4)	8640782	121	48	119	47	42	41	4	26	8	0	0.48	1.00	1.00
416	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(2), BAD(1), BCL2(1), CASP1(2), CASP10(3), CASP2(3), CASP3(1), CASP4(2), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CD40(1), CD40LG(4), CYCS(1), DAXX(3), DFFA(2), DFFB(2), FAS(3), IKBKE(5), LTA(2), NFKB1(5), NGFR(5), NR3C1(5), NTRK1(4), PTPN13(14), SFRS2IP(5), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF1(2), TRAF2(2), TRAF3(2), TRAF6(4)	8656801	102	47	102	43	23	33	8	29	9	0	0.76	1.00	1.00
417	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(3), CASP3(1), CASP6(1), CASP7(2), CASP8(6), DAXX(3), DFFA(2), DFFB(2), FAF1(4), JUN(2), LMNA(5), LMNB1(2), LMNB2(3), MAP2K4(5), MAP3K1(8), MAP3K7(7), MAPK8(4), PAK1(4), PAK2(5), PRKDC(22), PTPN13(14), RB1(8), RIPK2(2), SPTAN1(13)	8240878	128	47	127	38	29	44	5	28	22	0	0.15	1.00	1.00
418	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(6), ALDH1A3(6), ALDH3A1(5), ALDH3B2(4), AOC2(4), AOC3(3), DDC(3), EPX(4), ESCO2(2), GOT1(2), GOT2(3), HPD(1), LPO(2), MAOA(1), MAOB(3), MPO(5), MYST3(11), MYST4(15), NAT6(2), PNPLA3(2), PRDX6(1), SH3GLB1(1), TAT(1), TPO(13)	6770098	100	47	100	30	29	26	4	31	9	1	0.18	1.00	1.00
419	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(3), ALOX12(4), ALOX12B(3), ALOX15(2), ALOX15B(1), ALOX5(6), CBR1(1), CBR3(3), CYP2B6(2), CYP2C18(5), CYP2C19(6), CYP2C9(1), CYP2E1(5), CYP2J2(2), CYP2U1(2), CYP4A11(1), CYP4A22(1), CYP4F2(4), CYP4F3(3), DHRS4(1), EPHX2(4), GGT1(8), GPX1(1), GPX3(1), GPX4(3), GPX6(2), GPX7(3), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PTGES2(4), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(2)	7669748	121	47	119	31	43	32	5	31	10	0	0.018	1.00	1.00
420	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH5(1), ADH6(4), ADH7(2), ADHFE1(6), AKR1C1(1), AKR1C3(3), AKR1C4(3), ALDH1A3(6), ALDH3A1(5), ALDH3B2(4), CYP1A1(3), CYP1A2(3), CYP1B1(2), CYP2B6(2), CYP2C18(5), CYP2C19(6), CYP2C9(1), CYP2E1(5), CYP2F1(1), CYP2S1(3), CYP3A4(1), CYP3A43(3), CYP3A5(1), CYP3A7(2), DHDH(5), EPHX1(3), GSTA1(2), GSTA2(1), GSTA4(1), GSTA5(1), GSTM1(1), GSTM3(1), GSTM4(1), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(3), MGST1(2), MGST2(1), MGST3(1), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2)	11152074	135	47	134	47	33	47	2	36	17	0	0.28	1.00	1.00
421	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	BAG4(2), CASP2(3), CASP3(1), CASP8(6), DFFA(2), DFFB(2), JUN(2), LMNA(5), LMNB1(2), LMNB2(3), MADD(6), MAP2K4(5), MAP3K1(8), MAP3K7(7), MAPK8(4), PAK1(4), PAK2(5), PRKDC(22), RB1(8), SPTAN1(13), TNF(2), TNFRSF1A(3), TRAF2(2)	7763758	117	47	116	37	32	38	5	24	18	0	0.17	1.00	1.00
422	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(7), AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPS(3), CDS1(4), CDS2(1), CHAT(1), CHKA(1), CHKB(3), CLC(2), CPT1B(4), DGKA(3), DGKB(5), DGKD(1), DGKE(4), DGKG(1), DGKH(8), DGKQ(2), DGKZ(1), GNPAT(1), GPD1(3), GPD2(3), LCAT(1), LYPLA2(1), PAFAH1B1(3), PAFAH2(1), PCYT1A(7), PCYT1B(3), PEMT(1), PISD(4), PLA2G1B(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCB2(4), PLCG1(10), PLCG2(6), PPAP2C(5)	9881640	127	46	125	47	50	39	3	25	10	0	0.28	1.00	1.00
423	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(2), BAD(1), BCL2(1), CBL(2), GRB2(1), IL2RA(1), IL2RG(3), IRS1(7), JAK1(4), JAK3(3), MAPK1(2), MAPK3(1), NMI(1), PIK3CA(33), PIK3R1(7), PTPN6(3), RAF1(6), RPS6KB1(3), SHC1(3), SOCS1(1), SOCS3(3), SOS1(4), STAT5A(1), STAT5B(4), SYK(3)	7137769	100	46	85	36	20	45	3	18	13	1	0.43	1.00	1.00
424	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(7), BLNK(2), ELK1(2), GRB2(1), JUN(2), LYN(4), MAP2K1(4), MAP3K1(8), MAPK1(2), MAPK3(1), MAPK8IP3(9), PAPPA(14), RPS6KA1(6), RPS6KA3(1), SHC1(3), SOS1(4), SYK(3), VAV1(7), VAV2(8), VAV3(6)	6331828	94	46	94	40	28	31	3	19	13	0	0.70	1.00	1.00
425	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(3), ACTN2(15), ACTN3(2), CAPN1(3), CAPNS1(1), CAPNS2(1), ITGA1(4), ITGB1(4), ITGB3(5), PTK2(7), PXN(2), SPTAN1(13), TLN1(13)	5635503	74	46	72	38	31	18	4	15	6	0	0.89	1.00	1.00
426	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(2), AGTR2(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CDK5(2), F2(4), FYN(5), GNA11(4), GNAI1(1), GNB1(1), GNGT1(3), GRB2(1), JAK2(8), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(4), MAPT(4), MYLK(9), PLCG1(10), PTK2B(8), RAF1(6), SHC1(3), SOS1(4), STAT1(6), STAT3(7), STAT5A(1)	8239967	114	45	113	40	36	40	4	23	11	0	0.30	1.00	1.00
427	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(3), F11(3), F12(2), F13B(8), F2(4), F5(9), F7(6), F8(13), F9(4), FGA(5), FGB(3), FGG(2), LPA(11), PLAT(2), PLAU(2), PLG(10), SERPINB2(3), SERPINE1(2), SERPINF2(6), VWF(13)	6987063	111	45	111	33	32	33	5	28	13	0	0.12	1.00	1.00
428	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), ELK1(2), FPR1(1), GNA15(2), GNB1(1), GNGT1(3), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K6(2), MAP3K1(8), MAPK1(2), MAPK14(1), MAPK3(1), NCF1(2), NCF2(1), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), NFKB1(5), PAK1(4), PIK3C2G(3), PLCB1(12), PPP3CA(3), PPP3CB(1), RAF1(6), RELA(2)	7583960	107	45	107	35	32	34	2	24	15	0	0.22	1.00	1.00
429	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH3B2(4), ALDH9A1(4), ALDOB(4), ALDOC(3), BPGM(1), DLAT(6), DLD(2), ENO1(3), ENO2(1), ENO3(3), FBP1(1), FBP2(3), GAPDH(1), GCK(3), GPI(4), HK1(6), HK2(6), HK3(3), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKM(3), PFKP(8), PGK1(1), PGM1(3), PGM3(6), PKLR(4), PKM2(2), TPI1(2)	9649021	148	45	147	58	42	45	5	41	15	0	0.51	1.00	1.00
430	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(4), ADH1B(1), ADH1C(3), ADH4(2), ADH6(4), ADH7(2), ADHFE1(6), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH3B2(4), ALDH9A1(4), ALDOB(4), ALDOC(3), BPGM(1), DLAT(6), DLD(2), ENO1(3), ENO2(1), ENO3(3), FBP1(1), FBP2(3), GAPDH(1), GCK(3), GPI(4), HK1(6), HK2(6), HK3(3), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKM(3), PFKP(8), PGK1(1), PGM1(3), PGM3(6), PKLR(4), PKM2(2), TPI1(2)	9649021	148	45	147	58	42	45	5	41	15	0	0.51	1.00	1.00
431	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(3), C1GALT1(1), C1GALT1C1(4), GALNT1(3), GALNT10(3), GALNT11(5), GALNT12(2), GALNT13(3), GALNT14(6), GALNT2(3), GALNT3(1), GALNT4(1), GALNT5(4), GALNT6(2), GALNT8(5), GALNT9(3), GALNTL1(2), GALNTL2(6), GALNTL4(5), GALNTL5(4), GCNT1(1), GCNT3(2), GCNT4(2), OGT(2), ST3GAL1(3), ST3GAL2(4), ST6GALNAC1(2), WBSCR17(14)	6391037	96	45	93	35	37	30	4	21	4	0	0.43	1.00	1.00
432	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), AARS2(5), CARS(4), CARS2(2), DARS(2), EARS2(2), EPRS(6), FARS2(7), FARSA(3), FARSB(1), GARS(1), HARS(4), HARS2(3), IARS(7), IARS2(3), KARS(3), LARS(3), LARS2(5), MARS(3), MARS2(1), NARS(3), NARS2(1), PARS2(1), QARS(5), RARS(2), RARS2(2), SARS(4), SARS2(3), TARS(6), TARS2(6), VARS(8), VARS2(4), WARS(3), WARS2(5), YARS(1), YARS2(1)	10745285	122	45	121	47	42	42	3	29	6	0	0.62	1.00	1.00
433	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(2), CALR(4), CANX(1), CD4(3), CD74(1), CD8A(2), CD8B(1), CIITA(6), CREB1(4), CTSL1(2), CTSS(1), HLA-A(10), HLA-B(12), HLA-C(4), HLA-DMA(2), HLA-DMB(3), HLA-DOA(1), HLA-DPA1(2), HLA-DPB1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(3), HLA-DRB1(1), HLA-E(3), HLA-F(5), HLA-G(2), HSP90AA1(2), HSP90AB1(2), HSPA5(1), IFI30(1), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), KIR2DL1(4), KIR2DL3(1), KIR2DL4(3), KIR2DS4(2), KIR3DL1(2), KLRC1(2), KLRC2(2), KLRD1(2), LGMN(4), LTA(2), PDIA3(1), PSME2(2), RFX5(3), RFXANK(3), TAP1(3), TAP2(7), TAPBP(3)	9192723	143	45	140	46	21	51	14	31	23	3	0.21	1.00	1.00
434	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(2), ACTG2(6), ACTR2(2), AKT1(2), ANGPTL2(4), CDC42(1), CFL1(1), FLNA(11), FLNC(21), FSCN1(5), FSCN3(8), GDI1(1), LIMK1(4), MYH2(14), MYLK(9), MYLK2(3), PAK1(4), PAK2(5), PAK3(1), PAK4(5), PAK6(3), PAK7(2), PFN2(2), RHO(2), ROCK1(7), ROCK2(3), VASP(3), WASF1(4), WASL(1)	9459217	136	45	136	49	52	43	5	24	12	0	0.14	1.00	1.00
435	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), ELK1(2), IKBKB(3), IRAK1(5), JUN(2), LY96(1), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP3K1(8), MAP3K14(3), MAP3K7(7), MAPK14(1), MAPK8(4), MYD88(2), NFKB1(5), PPARA(3), RELA(2), TIRAP(2), TLR10(3), TLR2(3), TLR3(2), TLR4(13), TLR6(3), TLR7(3), TLR9(10), TOLLIP(1), TRAF6(4)	7214126	101	45	98	35	29	24	8	28	12	0	0.38	1.00	1.00
436	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(6), ACAT1(3), ACAT2(3), ACMSD(2), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), AOC2(4), AOC3(3), AOX1(3), ASMT(2), CAT(4), CYP19A1(5), CYP1A1(3), CYP1A2(3), CYP2A13(4), CYP2A6(2), CYP2A7(3), CYP2B6(2), CYP2C18(5), CYP2C19(6), CYP2C9(1), CYP2D6(3), CYP2E1(5), CYP2F1(1), CYP2J2(2), CYP3A4(1), CYP3A5(1), CYP3A7(2), CYP4B1(1), CYP4F8(2), CYP51A1(3), DDC(3), EHHADH(2), GCDH(3), HADHA(2), KYNU(6), MAOA(1), MAOB(3), SDS(1), TDO2(3), TPH1(1), WARS(3), WARS2(5)	10898594	151	45	148	49	45	47	5	34	18	2	0.13	1.00	1.00
437	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(4), ALDH4A1(2), ALDH5A1(3), CAD(7), CPS1(15), EPRS(6), GAD1(3), GAD2(4), GCLM(2), GFPT1(3), GLS(4), GLS2(5), GLUD1(4), GLUL(2), GMPS(3), GOT1(2), GOT2(3), GPT(1), GPT2(3), GSS(1), NADSYN1(5), PPAT(1), QARS(5)	6578621	88	44	86	30	31	28	5	19	5	0	0.33	1.00	1.00
438	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(2), ABAT(4), ACADS(1), ACAT1(3), ACAT2(3), ACSM1(1), AKR1B10(1), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH5A1(3), ALDH9A1(4), BDH1(1), DDHD1(7), EHHADH(2), GAD1(3), GAD2(4), HADH(2), HADHA(2), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(2), HSD3B7(3), ILVBL(3), L2HGDH(1), OXCT1(4), PDHA1(1), PDHA2(4), PDHB(2), PRDX6(1), RDH11(1), RDH12(1)	8032647	91	44	88	34	30	24	1	27	9	0	0.42	1.00	1.00
439	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(9), ATP4B(2), ATP6AP1(4), ATP6V0A1(4), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), ATP7A(5), ATP7B(12), COX10(1), COX4I1(4), COX6B1(1), COX7A2(2), COX7C(1), NDUFA1(1), NDUFA10(1), NDUFA8(1), NDUFB2(1), NDUFB7(1), NDUFS1(5), NDUFS2(2), NDUFV1(1), PPA2(2), SDHA(5), SDHB(4), SHMT1(1), UQCRB(1), UQCRC1(2), UQCRFS1(1)	7537276	107	44	107	38	28	40	7	23	9	0	0.31	1.00	1.00
440	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(3), APC(20), AXIN1(7), BTRC(3), CTNNB1(11), DLL1(3), DVL1(4), FZD1(8), GSK3B(2), NOTCH1(15), PSEN1(1), WNT1(3)	4179091	80	44	78	35	27	16	2	18	15	2	0.78	1.00	1.00
441	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(2), AKT3(3), ARHGEF11(12), BCL2(1), CDC42(1), DLG4(5), LPA(11), MAP2K4(5), MAP3K1(8), MAP3K5(3), MAPK8(4), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PDK1(1), PHKA2(7), PI3(2), PIK3CB(6), PLD1(7), PLD2(11), PLD3(5), PTK2(7), RDX(2), ROCK1(7), ROCK2(3), SERPINA4(2), SRF(1), TBXA2R(7)	9724990	143	44	143	49	47	46	8	26	16	0	0.23	1.00	1.00
442	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(3), ALG10(5), ALG10B(2), ALG12(1), ALG13(2), ALG2(1), ALG3(2), ALG8(1), ALG9(2), B4GALT1(2), B4GALT2(5), B4GALT3(1), DOLPP1(2), DPM1(1), FUT8(3), GANAB(3), MAN1A2(1), MAN1B1(2), MAN1C1(3), MAN2A1(7), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(1), MGAT5(6), MGAT5B(3), RFT1(2), RPN1(1), RPN2(3), STT3B(5)	8408701	81	43	80	43	21	22	5	20	13	0	0.98	1.00	1.00
443	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(4), ARRB2(3), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2B(2), CAMK2G(4), CLCA1(3), CLCA2(6), CLCA4(6), CNGA3(6), CNGA4(9), CNGB1(7), GUCA1A(1), GUCA1C(1), PDC(1), PDE1C(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKG1(6), PRKG2(6), PRKX(2)	6056900	84	43	82	33	28	23	4	20	9	0	0.50	1.00	1.00
444	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(2), EIF4A1(2), EIF4A2(3), EIF4B(2), EIF4E(1), EIF4EBP1(1), EIF4G1(10), EIF4G2(1), EIF4G3(5), MKNK1(1), PDPK1(1), PIK3CA(33), PIK3R1(7), PPP2CA(3), PTEN(8), RPS6(1), RPS6KB1(3), TSC1(4), TSC2(4)	5483574	92	43	78	35	21	42	4	15	10	0	0.58	1.00	1.00
445	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(2), CALM1(1), CALM2(2), CALM3(1), CD79A(6), ELK1(2), GRB2(1), JUN(2), LYN(4), MAP2K1(4), MAP3K1(8), MAPK14(1), MAPK3(1), MAPK8(4), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), PLCG1(10), PPP3CA(3), PPP3CB(1), RAF1(6), SHC1(3), SOS1(4), SYK(3), VAV1(7)	7539272	109	42	107	33	37	38	2	20	12	0	0.093	1.00	1.00
446	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(2), CDC7(3), CDK2(2), CDT1(2), DIAPH2(3), MCM10(5), MCM2(9), MCM3(4), MCM4(6), MCM5(8), MCM6(1), MCM7(5), NACA(1), ORC1L(10), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(2), POLD1(7), POLD3(2), POLE(14), POLE2(2), PRIM1(1), RFC1(1), RFC2(1), RFC3(4), RFC4(1), RPA1(1), RPA2(1), RPA3(1), RPS27A(1), UBC(3)	10078556	117	42	116	50	39	29	6	22	21	0	0.82	1.00	1.00
447	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(11), CALM1(1), CALM2(2), CALM3(1), CREB1(4), ELK1(2), GNAI1(1), GNAQ(1), GNAS(14), GNB1(1), GNGT1(3), JUN(2), MAP2K1(4), MAPK3(1), NFATC1(9), NFATC2(8), NFATC3(3), NFATC4(11), PLCG1(10), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RAF1(6), RPS6KA3(1)	6873696	115	42	113	37	40	43	1	20	11	0	0.11	1.00	1.00
448	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(15), ACAT1(3), ACAT2(3), ACYP2(1), ADH5(1), AKR1B1(5), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), DLAT(6), DLD(2), GRHPR(2), HAGH(2), LDHB(2), LDHC(1), LDHD(2), MDH1(3), MDH2(1), ME1(3), ME2(4), ME3(5), PC(6), PCK1(4), PDHA1(1), PDHA2(4), PDHB(2), PKLR(4), PKM2(2)	7292657	116	42	116	34	34	35	5	28	14	0	0.079	1.00	1.00
449	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(3), CLOCK(2), CRY1(1), CRY2(2), DAZAP2(3), DNAJA1(2), EIF4G2(1), ETV6(3), G0S2(1), GFRA1(5), GSTM3(1), GSTP1(1), HERPUD1(1), HSPA8(5), KLF9(1), MYF6(2), NCKAP1(6), NR1D2(4), PER1(4), PER2(10), PPP1R3C(3), PPP2CB(3), PSMA4(3), PURA(1), SF3A3(2), SUMO3(1), TOB1(1), TUBB3(8), UCP3(2), UGP2(1), ZFR(7)	7197869	90	41	90	37	28	28	3	26	5	0	0.67	1.00	1.00
450	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(4), AASDH(4), AASS(2), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH9A1(4), BBOX1(1), DLST(1), DOT1L(9), EHHADH(2), EHMT1(7), EHMT2(4), GCDH(3), HADHA(2), PLOD1(6), PLOD2(3), PLOD3(4), SDS(1), SHMT1(1), SHMT2(4), TMLHE(4)	7296757	100	41	99	42	25	36	3	20	16	0	0.55	1.00	1.00
451	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(11), CD3E(3), CD3G(2), CD4(3), CREBBP(13), CSK(3), GNAS(14), GNB1(1), GNGT1(3), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PTPRC(16), ZAP70(4)	4528093	93	40	90	40	24	30	2	20	17	0	0.81	1.00	1.00
452	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(4), CFL1(1), GNAQ(1), GNAS(14), GNB1(1), GNGT1(3), LIMK1(4), MAP2K1(4), MAPK1(2), MAPK3(1), MYL2(1), NOX1(4), PIK3C2G(3), PLCB1(12), PPP1R12B(7), PTK2(7), RAF1(6), ROCK2(3)	5019116	79	40	78	24	28	17	4	17	13	0	0.35	1.00	1.00
453	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(11), CD3E(3), CD3G(2), CD4(3), CREBBP(13), CSK(3), GNAS(14), GNB1(1), GNGT1(3), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PTPRC(16), ZAP70(4)	4528093	93	40	90	40	24	30	2	20	17	0	0.81	1.00	1.00
454	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(10), ELK1(2), GNAS(14), GNB1(1), GNGT1(3), GRB2(1), IGF1R(11), ITGB1(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MKNK1(1), NGFR(5), PDGFRA(4), PPP2CA(3), PTPRR(4), RAF1(6), RPS6KA1(6), SHC1(3), SOS1(4), STAT3(7)	6521941	97	40	95	40	30	33	1	22	11	0	0.69	1.00	1.00
455	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(4), ALDOC(3), DLAT(6), DLD(2), ENO1(3), ENO2(1), ENO3(3), FBP1(1), FBP2(3), GAPDH(1), GAPDHS(2), GCK(3), GOT1(2), GOT2(3), GPI(4), HK1(6), HK2(6), HK3(3), LDHAL6B(2), LDHB(2), LDHC(1), MDH1(3), MDH2(1), PC(6), PCK1(4), PDHA1(1), PDHA2(4), PDHB(2), PDHX(2), PFKL(7), PFKM(3), PFKP(8), PGAM2(2), PGK1(1), PGK2(1), PKLR(4), PKM2(2), TNFAIP1(3), TPI1(2)	8371115	117	40	117	48	50	35	4	22	6	0	0.48	1.00	1.00
456	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(3), AKR1D1(2), ARSD(1), ARSE(3), CARM1(2), CYP11B1(2), CYP11B2(2), CYP19A1(5), HSD11B1(1), HSD11B2(2), HSD17B1(3), HSD17B12(2), HSD17B2(1), HSD17B3(2), HSD17B7(1), HSD3B1(1), HSD3B2(1), LCMT1(1), LCMT2(7), METTL6(1), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), SRD5A1(2), SRD5A2(3), STS(4), SULT1E1(3), SULT2A1(1), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), WBSCR22(2)	9748406	96	40	96	38	25	36	3	18	14	0	0.47	1.00	1.00
457	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(4), ACAA1(1), ACAA2(1), ACADM(1), ACADS(1), ACAT1(3), ACAT2(3), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH6A1(1), ALDH9A1(4), AOX1(3), AUH(5), BCAT1(2), BCAT2(1), BCKDHA(4), DBT(2), DLD(2), EHHADH(2), HADH(2), HADHA(2), HADHB(2), HIBADH(2), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(2), IVD(1), MCCC1(3), MCCC2(2), MCEE(3), MUT(3), OXCT1(4), PCCA(7), PCCB(2)	8523895	98	40	94	34	23	30	1	23	20	1	0.44	1.00	1.00
458	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(9), EXT2(6), EXTL1(4), EXTL2(2), EXTL3(8), GLCE(2), HS2ST1(1), HS3ST1(1), HS3ST2(7), HS3ST3A1(1), HS3ST3B1(2), HS3ST5(4), HS6ST1(2), HS6ST2(1), HS6ST3(4), NDST1(8), NDST2(5), NDST3(5), NDST4(10)	4080441	82	40	81	33	27	32	1	16	6	0	0.62	1.00	1.00
459	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ARHGAP4(2), ARHGAP5(6), ARHGAP6(3), ARHGEF1(2), ARHGEF11(12), ARHGEF5(5), ARPC1A(3), ARPC1B(1), ARPC4(1), BAIAP2(3), CFL1(1), DIAPH1(4), GSN(5), LIMK1(4), MYL2(1), MYLK(9), OPHN1(6), PIP5K1A(3), PPP1R12B(7), ROCK1(7), TLN1(13), VCL(2)	8988188	102	40	102	49	38	34	3	17	9	1	0.88	1.00	1.00
460	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(2), CAMK2G(4), DAG1(7), ITPKA(1), ITPKB(6), ITPR1(17), ITPR2(18), ITPR3(16), NFAT5(5), PDE6A(5), PDE6B(7), PDE6C(2), PDE6G(1), SLC6A13(1), TF(6)	7129506	99	40	99	40	32	31	8	13	14	1	0.49	1.00	1.00
461	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(16), MAP2(18), PPP1CA(2), PPP2CA(3), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAR2A(1), PRKAR2B(6), PRKCE(6)	3610025	59	39	58	23	11	22	0	20	6	0	0.74	1.00	1.00
462	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(2), AGTR1(1), CALM1(1), CALM2(2), CALM3(1), EGFR(10), ELK1(2), GNAQ(1), GRB2(1), JUN(2), MAP2K1(4), MAP2K2(1), MAP2K4(5), MAP3K1(8), MAPK1(2), MAPK3(1), MAPK8(4), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), PAK1(4), PTK2(7), PTK2B(8), RAF1(6), SHC1(3), SOS1(4)	6640676	92	39	92	33	27	27	6	19	13	0	0.35	1.00	1.00
463	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(1), ARSE(3), ASAH1(2), B4GALT6(2), CERK(3), DEGS1(1), DEGS2(2), ENPP7(4), GAL3ST1(4), GALC(5), GBA(4), GLB1(3), LCT(11), NEU1(1), NEU2(2), NEU3(2), NEU4(2), PPAP2C(5), SGMS1(2), SMPD1(4), SMPD3(5), SMPD4(3), SPHK1(5), SPTLC2(3), UGT8(4)	7037637	84	39	84	42	39	30	1	10	4	0	0.76	1.00	1.00
464	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ACTG2(6), ADCY3(3), ADCY9(6), ARF1(2), ARL4D(1), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), ERO1L(1), GNAS(14), PLCG1(10), PLCG2(6), SEC61A1(1), SEC61A2(1), SEC61B(1), SEC61G(1), TRIM23(2)	7323692	89	39	87	35	33	24	3	23	6	0	0.58	1.00	1.00
465	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(3), CAPN2(4), CAPNS1(1), CAPNS2(1), EGF(5), EGFR(10), ITGA1(4), ITGB1(4), MAPK1(2), MAPK3(1), MYL2(1), MYLK(9), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), PTK2(7), PXN(2), TLN1(13)	6464962	83	39	81	41	30	23	4	16	10	0	0.80	1.00	1.00
466	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(2), BCL2(1), BID(1), BIRC2(2), BIRC3(4), CASP10(3), CASP3(1), CASP6(1), CASP7(2), CASP8(6), CASP9(1), CYCS(1), DFFA(2), DFFB(2), GAS2(1), LMNA(5), MAP3K14(3), NFKB1(5), RELA(2), SPTAN1(13), TNFRSF10A(2), TNFRSF10B(2), TNFRSF25(2), TNFSF10(2), TRAF2(2)	6601643	68	38	68	20	17	18	2	21	10	0	0.38	1.00	1.00
467	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(3), ARSB(3), FUCA1(1), FUCA2(2), GALNS(2), GBA(4), GLB1(3), GNS(3), GUSB(3), HEXA(1), HEXB(3), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(2), HYAL2(4), IDS(3), IDUA(1), LCT(11), MAN2B1(8), MAN2B2(9), MAN2C1(4), MANBA(2), NAGLU(2), NEU1(1), NEU2(2), NEU3(2), NEU4(2), SPAM1(5)	6795121	93	38	92	38	35	33	2	15	8	0	0.54	1.00	1.00
468	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(14), ANAPC11(1), ANAPC2(3), ANAPC4(2), ANAPC5(2), ANAPC7(1), BTRC(3), CDC16(1), CDC20(2), CDC23(4), CDC26(1), CDC27(2), CUL1(10), CUL2(4), CUL3(4), FBXW11(5), FBXW7(11), FZR1(3), ITCH(3), SKP2(4), SMURF1(1), SMURF2(1), TCEB1(1), UBA1(1), UBE2D3(1), UBE2E3(3), WWP1(8), WWP2(10)	7995810	106	38	96	32	30	39	1	21	15	0	0.20	1.00	1.00
469	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CDC42(1), CREB1(4), DAXX(3), DDIT3(3), ELK1(2), GRB2(1), HSPB1(1), HSPB2(1), MAP2K4(5), MAP2K6(2), MAP3K1(8), MAP3K5(3), MAP3K7(7), MAP3K9(5), MAPK14(1), MAPKAPK5(2), MAX(1), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), MKNK1(1), PLA2G4A(3), SHC1(3), STAT1(6), TGFB1(3), TGFB2(6), TGFB3(4), TGFBR1(2), TRAF2(2)	7265538	92	38	92	31	31	32	3	14	12	0	0.23	1.00	1.00
470	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), CDC42(1), CREB1(4), CREB3(3), CREB5(2), DUSP1(1), DUSP10(3), EEF2K(8), EIF4E(1), ELK1(2), HSPB1(1), IL1R1(3), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP3K10(6), MAP3K4(10), MAP3K5(3), MAP3K7(7), MAPK1(2), MAPK11(1), MAPK13(1), MAPK14(1), MAPKAPK5(2), MKNK1(1), MYEF2(4), NFKB1(5), NR2C2(3), SRF(1), TRAF6(4)	6586325	90	38	89	35	28	31	5	14	12	0	0.50	1.00	1.00
471	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), ABAT(4), ADSL(4), ADSS(3), AGXT(1), AGXT2(6), ASL(5), ASNS(4), CAD(7), CRAT(3), DARS(2), DDO(2), GAD1(3), GAD2(4), GOT1(2), GOT2(3), GPT(1), GPT2(3), NARS(3), PC(6)	5146752	68	37	66	28	31	18	1	15	3	0	0.58	1.00	1.00
472	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(3), ACTN2(15), ACTN3(2), BCAR1(4), CSK(3), CTNNA1(5), CTNNA2(13), CTNNB1(11), PTK2(7), PXN(2), VCL(2)	3758606	67	37	66	29	19	21	4	15	8	0	0.71	1.00	1.00
473	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(2), EGF(5), EGFR(10), GRB2(1), MAP2K1(4), MAPK1(2), MAPK3(1), PTPRB(12), RAF1(6), RASA1(10), SHC1(3), SOS1(4), SPRY1(2), SPRY2(1), SPRY3(4), SPRY4(3)	4961875	70	37	69	24	15	18	2	20	14	1	0.51	1.00	1.00
474	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BAD(1), BRAF(5), CREB1(4), CREB3(3), CREB5(2), DUSP4(1), DUSP6(1), DUSP9(2), EEF2K(8), EIF4E(1), GRB2(1), MAP2K1(4), MAP2K2(1), MAP3K8(1), MAPK1(2), MAPK3(1), MKNK1(1), MOS(3), NFKB1(5), RAP1A(2), RPS6KA1(6), RPS6KA2(7), RPS6KA3(1), SHC1(3), SOS1(4), SOS2(5), TRAF3(2)	5838942	77	37	76	31	24	24	1	18	10	0	0.67	1.00	1.00
475	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(9), CLYBL(1), DLD(2), DLST(1), FH(2), IDH1(1), IDH2(1), IDH3A(1), IDH3B(3), IDH3G(2), MDH1(3), MDH2(1), OGDH(8), OGDHL(3), PC(6), PCK1(4), PCK2(6), SDHA(5), SDHB(4), SDHC(1), SUCLA2(3), SUCLG1(2), SUCLG2(4)	5898386	75	36	73	27	29	20	4	14	8	0	0.36	1.00	1.00
476	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(1), B3GNT7(4), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), CHST1(11), CHST2(8), CHST6(5), FUT8(3), ST3GAL1(3), ST3GAL2(4), ST3GAL3(2), ST3GAL4(3)	2455818	56	36	55	26	29	12	1	12	2	0	0.76	1.00	1.00
477	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(4), ACACA(15), ACACB(13), ACADM(1), ACAT1(3), ACAT2(3), ACSS1(7), ACSS2(3), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH6A1(1), ALDH9A1(4), EHHADH(2), HADHA(2), LDHAL6B(2), LDHB(2), LDHC(1), MCEE(3), MLYCD(3), MUT(3), PCCA(7), PCCB(2), SUCLA2(3), SUCLG1(2), SUCLG2(4)	7842939	110	36	106	34	30	29	2	26	23	0	0.22	1.00	1.00
478	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(4), ALAS1(2), ALAS2(4), BLVRA(2), COX10(1), COX15(3), CP(5), CPOX(1), EARS2(2), EPRS(6), FECH(5), FTH1(1), FTMT(2), GUSB(3), HCCS(1), HMOX1(3), MMAB(1), PPOX(2), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), UROD(1), UROS(3)	8152186	76	36	76	43	15	28	3	22	8	0	0.99	1.00	1.00
479	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLAT(6), DLD(2), DLST(1), FH(2), IDH2(1), IDH3A(1), IDH3B(3), IDH3G(2), MDH1(3), MDH2(1), OGDH(8), PC(6), PDHA1(1), PDHA2(4), PDHB(2), PDHX(2), PDK1(1), PDK3(2), PDP2(2), SDHA(5), SDHB(4), SDHC(1), SUCLA2(3), SUCLG1(2), SUCLG2(4)	5599047	69	36	68	33	22	17	3	19	8	0	0.90	1.00	1.00
480	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACAA2(1), ACADL(2), ACADM(1), ACADS(1), ACADSB(3), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH6A1(1), ALDH9A1(4), AOX1(3), BCAT1(2), BCKDHA(4), EHHADH(2), HADHA(2), HADHB(2), HIBADH(2), HMGCL(1), IVD(1), MCCC1(3), MCCC2(2), MCEE(3), MUT(3), OXCT1(4), PCCA(7), PCCB(2), SDS(1)	7124179	92	36	89	35	17	34	0	22	18	1	0.62	1.00	1.00
481	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ABAT(4), ACADS(1), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(6), ALDH1B1(3), ALDH2(1), ALDH3A1(5), ALDH3A2(5), ALDH5A1(3), ALDH9A1(4), EHHADH(2), GAD1(3), GAD2(4), HADHA(2), HMGCL(1), L2HGDH(1), OXCT1(4), PDHA1(1), PDHA2(4), PDHB(2), SDHB(4), SDS(1)	5090684	77	35	75	30	23	22	1	22	9	0	0.50	1.00	1.00
482	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD2(2), CD33(2), CD5(5), CD7(4), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(2), IL13(2), IL3(1), ITGAX(6), TLR2(3), TLR4(13), TLR7(3), TLR9(10)	3687923	62	35	58	31	21	13	6	17	5	0	0.90	1.00	1.00
483	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(5), AKR1B10(1), B4GALT1(2), B4GALT2(5), GAA(2), GALE(1), GALK1(2), GALK2(2), GALT(1), GANC(4), GCK(3), GLB1(3), HK1(6), HK2(6), HK3(3), HSD3B7(3), LALBA(1), LCT(11), MGAM(7), PFKL(7), PFKM(3), PFKP(8), PGM1(3), PGM3(6), RDH11(1), RDH12(1), UGP2(1)	7644031	98	35	97	43	46	33	4	9	6	0	0.54	1.00	1.00
484	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(4), POLA2(2), POLD1(7), POLD3(2), POLE(14), POLE2(2), POLE3(1), POLE4(1), POLG(4), POLG2(3), POLH(2), POLK(3), POLL(1), POLM(3), POLQ(14), PRIM1(1), PRIM2(3), REV1(5), REV3L(17)	8111175	89	35	89	43	22	29	2	18	18	0	0.95	1.00	1.00
485	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(11), CAP1(2), CCNB1(1), CDC25C(3), GNAI1(1), GNAS(14), GNB1(1), GNGT1(3), MAPK1(2), MAPK3(1), MYT1(12), PIN1(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RPS6KA1(6)	4049240	74	35	73	34	28	24	1	14	7	0	0.76	1.00	1.00
486	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(3), ANXA2(1), ANXA4(2), ANXA5(1), ANXA6(2), CYP11A1(2), EDN1(3), EDNRA(3), EDNRB(13), HSD11B1(1), HSD11B2(2), PLA2G4A(3), PRL(2), PTGDR(5), PTGER2(2), PTGER4(1), PTGFR(3), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(2)	4098427	63	35	62	26	15	22	4	13	9	0	0.69	1.00	1.00
487	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(4), CALM1(1), CALM2(2), CALM3(1), GNAQ(1), GRB2(1), JUN(2), MAP2K1(4), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP3K1(8), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(4), PAK1(4), PLCG1(10), PTK2B(8), RAF1(6), SHC1(3), SOS1(4)	5608885	74	35	73	27	23	23	1	17	10	0	0.51	1.00	1.00
488	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(5), DYRK1B(6), GLI2(9), GLI3(16), GSK3B(2), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), SMO(6), SUFU(3)	3254678	62	35	62	31	18	17	2	17	8	0	0.81	1.00	1.00
489	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), CARS(4), DARS(2), EPRS(6), FARS2(7), GARS(1), HARS(4), IARS(7), KARS(3), LARS(3), LARS2(5), MARS(3), MARS2(1), NARS(3), QARS(5), RARS(2), SARS(4), TARS(6), WARS(3), WARS2(5), YARS(1)	6357797	77	34	76	24	23	30	2	18	4	0	0.24	1.00	1.00
490	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(1), ATG7(4), BECN1(1), GABARAPL1(3), IFNA1(1), IFNA10(2), IFNA16(1), IFNA17(3), IFNA5(2), IFNA6(1), IFNA7(2), IFNA8(1), IFNG(2), PIK3C3(8), PIK3R4(8), PRKAA1(1), PRKAA2(3), ULK1(11), ULK2(4), ULK3(2)	4186451	62	34	62	21	14	18	6	15	9	0	0.38	1.00	1.00
491	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(4), F2R(2), GNAI1(1), GNB1(1), GNGT1(3), ITGA1(4), ITGB1(4), MAP2K1(4), MAPK1(2), MAPK3(1), PLA2G4A(3), PLCB1(12), PTGS1(5), PTK2(7), RAF1(6), SYK(3), TBXAS1(2)	4809425	64	34	63	27	17	20	5	13	9	0	0.70	1.00	1.00
492	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM2(2), CALM3(1), EGR2(3), EGR3(1), GNAQ(1), MAP3K1(8), NFATC1(9), NFATC2(8), NFKB1(5), PLCG1(10), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6), RELA(2), VIP(1), VIPR2(4)	5516699	75	34	74	32	27	26	1	15	6	0	0.58	1.00	1.00
493	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP2(3), ACP5(2), ACPP(3), ACPT(1), ALPI(4), ALPL(3), ALPP(5), ALPPL2(4), CYP19A1(5), CYP1A1(3), CYP1A2(3), CYP2A13(4), CYP2A6(2), CYP2A7(3), CYP2B6(2), CYP2C18(5), CYP2C19(6), CYP2C9(1), CYP2D6(3), CYP2E1(5), CYP2F1(1), CYP2J2(2), CYP3A4(1), CYP3A5(1), CYP3A7(2), CYP4B1(1), CYP4F8(2), CYP51A1(3), PON1(1)	5772592	81	33	80	25	35	23	3	14	6	0	0.11	1.00	1.00
494	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(5), AKR1B10(1), ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), FPGT(3), FUK(1), GMDS(2), GMPPA(4), HK1(6), HK2(6), HK3(3), HSD3B7(3), LHPP(3), MTMR1(3), MTMR2(3), MTMR6(4), PFKFB2(5), PFKFB3(2), PFKFB4(1), PFKL(7), PFKM(3), PFKP(8), PGM2(2), PHPT1(3), PMM1(1), PMM2(1), RDH11(1), RDH12(1), TPI1(2), TSTA3(4)	7358127	99	33	99	32	43	35	3	14	4	0	0.070	1.00	1.00
495	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), ERCC3(3), GTF2B(1), GTF2E1(5), GTF2E2(2), GTF2F2(2), GTF2H1(1), ILK(2), MNAT1(2), POLR1A(8), POLR1B(2), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3B(6), POLR3D(1), POLR3E(1), POLR3K(1), TAF13(1), TAF5(2), TAF6(7), TAF7(4), TBP(3)	6943057	73	33	73	28	24	22	2	17	8	0	0.56	1.00	1.00
496	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(7), DDX20(3), ETS1(4), ETS2(1), HDAC2(4), HDAC5(4), JUN(2), NCOR2(15), RBL1(5), RBL2(1), SIN3A(5), SIN3B(8)	5094510	59	32	59	28	19	13	1	22	4	0	0.87	1.00	1.00
497	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2(4), F2R(2), F3(1), F5(9), F7(6), FGA(5), FGB(3), FGG(2), PROC(3), PROS1(6), SERPINC1(2), TFPI(3)	3250220	49	32	48	18	14	11	2	18	4	0	0.61	1.00	1.00
498	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CARM1(2), CBS(3), CTH(2), GGT1(8), LCMT1(1), LCMT2(7), MARS(3), MARS2(1), MAT1A(3), MAT2B(1), METTL6(1), PAPSS1(4), PAPSS2(2), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(4), SCLY(1), SEPHS1(1), SEPHS2(1), WBSCR22(2)	4921872	57	32	56	23	17	19	2	10	9	0	0.50	1.00	1.00
499	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(4), ACE2(5), AGT(2), AGTR1(1), AGTR2(1), ANPEP(3), CPA3(1), CTSG(3), ENPEP(8), LNPEP(9), MAS1(2), MME(5), NLN(7), REN(3), THOP1(5)	4178900	59	32	59	22	18	25	2	13	1	0	0.35	1.00	1.00
500	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(5), B4GALT1(2), B4GALT2(5), FBP2(3), GAA(2), GALE(1), GALK1(2), GALK2(2), GALT(1), GANAB(3), GCK(3), GLB1(3), HK1(6), HK2(6), HK3(3), LALBA(1), LCT(11), MGAM(7), PFKM(3), PFKP(8), PGM1(3), PGM3(6)	6455422	86	31	85	39	41	25	4	8	8	0	0.68	1.00	1.00
501	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(1), ALOX15(2), ALOX5(6), CYP1A2(3), CYP2C18(5), CYP2C19(6), CYP2C9(1), CYP2E1(5), CYP2J2(2), CYP3A4(1), CYP3A43(3), CYP3A5(1), CYP3A7(2), HSD3B7(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), RDH11(1), RDH12(1)	4734081	64	31	64	21	22	19	2	16	5	0	0.25	1.00	1.00
502	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(3), B4GALNT1(2), GLB1(3), HEXA(1), HEXB(3), LCT(11), SLC33A1(4), ST3GAL1(3), ST3GAL2(4), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC4(2), ST6GALNAC5(1), ST6GALNAC6(3), ST8SIA1(4), ST8SIA5(2)	3248951	50	31	50	24	21	14	1	12	2	0	0.76	1.00	1.00
503	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(11), GNAS(14), GNB1(1), GNGT1(3), PPP2CA(3), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAB2(1), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6)	3024169	57	30	56	22	22	19	1	8	7	0	0.59	1.00	1.00
504	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(5), EGFR(10), MAP2K1(4), MAP3K1(8), MAPK14(1), NCOR2(15), RARA(2), RXRA(3), THRA(4), THRB(5)	3390609	57	30	57	24	22	12	1	15	7	0	0.59	1.00	1.00
505	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(3), ARSD(1), ARSE(3), ASAH1(2), GAL3ST1(4), GALC(5), GBA(4), GLB1(3), LCT(11), NEU1(1), NEU2(2), NEU3(2), NEU4(2), PPAP2C(5), SMPD1(4), SPTLC2(3)	4767684	56	30	56	34	27	22	0	4	3	0	0.94	1.00	1.00
506	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(4), ELK1(2), GRB2(1), IL6(1), IL6ST(2), JAK1(4), JAK2(8), JAK3(3), JUN(2), MAP2K1(4), MAPK3(1), PTPN11(4), RAF1(6), SHC1(3), SOS1(4), SRF(1), STAT3(7)	4716154	57	30	57	23	10	24	1	16	5	1	0.66	1.00	1.00
507	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(1), AP2M1(7), ARF1(2), BAD(1), BTK(2), EEA1(3), GRASP(1), GSK3A(1), GSK3B(2), LYN(4), PDPK1(1), PFKL(7), PFKM(3), PFKP(8), PLCG1(10), PRKCE(6), RAB5A(2), RPS6KB1(3), VAV2(8)	4945101	74	30	73	27	28	25	3	14	4	0	0.31	1.00	1.00
508	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(5), CCNB1(1), CCND1(1), CCND2(1), CCND3(2), CCNE1(3), CCNH(2), CDC25A(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(4), CDKN2D(1), RB1(8), RBL1(5), TFDP1(2)	3170298	44	29	43	22	11	13	1	15	4	0	0.86	1.00	1.00
509	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(2), BHMT(5), CBS(3), CTH(2), DNMT1(12), DNMT3A(7), DNMT3B(7), MARS(3), MARS2(1), MAT1A(3), MAT2B(1), MTR(9), SRM(1), TAT(1)	4087206	57	29	57	34	21	19	2	12	3	0	0.96	1.00	1.00
510	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(8), POLR1B(2), POLR1C(2), POLR1D(1), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(6), POLR3G(1), POLR3K(1)	4660849	49	29	49	18	14	18	1	13	3	0	0.49	1.00	1.00
511	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(5), ICAM1(2), ITGA4(8), ITGAL(7), ITGAM(5), ITGB1(4), ITGB2(6), SELE(3), SELL(4), SELP(2)	3170318	46	29	45	24	16	8	2	13	7	0	0.90	1.00	1.00
512	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(6), ARHGEF1(2), GNA12(1), GNAQ(1), GNB1(1), GNGT1(3), MYL2(1), MYLK(9), PLCB1(12), PPP1R12B(7), ROCK1(7)	4092582	50	29	50	24	16	13	0	12	8	1	0.91	1.00	1.00
513	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(4), ATP6V0A1(4), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), SHMT1(1)	2985174	42	28	42	18	7	19	3	11	2	0	0.68	1.00	1.00
514	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(7), EPHB1(14), FYN(5), ITGA1(4), ITGB1(4), L1CAM(3), LYN(4), RAP1B(4), SELP(2)	3129109	48	28	47	26	17	11	4	13	3	0	0.90	1.00	1.00
515	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(4), ATP6V0A1(4), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), SHMT1(1)	2985174	42	28	42	18	7	19	3	11	2	0	0.68	1.00	1.00
516	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(3), FUCA1(1), FUCA2(2), GLB1(3), HEXA(1), HEXB(3), LCT(11), MAN2B1(8), MAN2B2(9), MAN2C1(4), MANBA(2), NEU1(1), NEU2(2), NEU3(2), NEU4(2)	4008904	54	28	54	24	25	14	0	8	7	0	0.71	1.00	1.00
517	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(3), GALNS(2), GLB1(3), GNS(3), GUSB(3), HEXA(1), HEXB(3), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(2), HYAL2(4), IDS(3), IDUA(1), LCT(11), NAGLU(2), SPAM1(5)	4045038	53	28	52	23	17	22	2	10	2	0	0.64	1.00	1.00
518	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT5(3), DPM1(1), FUT8(3), MAN1B1(2), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(1), MGAT5(6), RPN1(1), RPN2(3)	3928604	41	28	40	28	13	10	1	13	4	0	1.00	1.00	1.00
519	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(2), CCR2(3), CCR3(4), CCR5(1), CD4(3), CXCR4(2), IFNG(2), IFNGR1(2), IFNGR2(1), IL12B(2), IL12RB1(4), IL12RB2(5), IL18R1(2), IL2(1), IL4R(1), TGFB1(3), TGFB2(6), TGFB3(4)	3952435	48	28	48	21	10	16	2	14	6	0	0.73	1.00	1.00
520	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2G(4), CAMK4(4), HDAC5(4), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), PPARA(3), PPP3CA(3), PPP3CB(1), SLC2A4(1), YWHAH(1)	3996049	44	28	44	16	15	12	2	11	4	0	0.43	1.00	1.00
521	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(4), ATP6V0A1(4), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), FDXR(2), SHMT1(1)	3173221	44	28	44	19	8	19	3	11	3	0	0.68	1.00	1.00
522	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(11), ADRB2(4), GNAS(14), PLCE1(9), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6)	2913100	53	28	52	22	17	21	0	10	5	0	0.63	1.00	1.00
523	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(13), EP300(15), HDAC3(4), IKBKB(3), NFKB1(5), RELA(2), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TRAF6(4)	4411752	52	28	52	19	14	15	2	9	12	0	0.53	1.00	1.00
524	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(6), APOA1(2), APOA4(1), APOC1(1), APOC2(2), CETP(2), CYP7A1(3), HMGCR(5), LCAT(1), LDLR(4), LIPC(2), LPL(2), LRP1(23), SCARB1(3), SOAT1(5)	5414420	62	28	62	33	23	18	4	12	5	0	0.90	1.00	1.00
525	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(4), ATP6V0A1(4), ATP6V0A4(5), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1B2(2), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), SHMT1(1)	2985174	42	28	42	18	7	19	3	11	2	0	0.68	1.00	1.00
526	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(3), AKR1D1(2), ARSB(3), ARSD(1), ARSE(3), CYP11B1(2), CYP11B2(2), HSD11B1(1), HSD11B2(2), HSD17B2(1), HSD17B3(2), HSD3B1(1), HSD3B2(1), SRD5A1(2), SRD5A2(3), STS(4), SULT1E1(3), SULT2A1(1), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2B15(1), UGT2B4(2)	5416915	45	27	45	20	14	19	0	5	7	0	0.63	1.00	1.00
527	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(3), IL13(2), MAF(2), MAP2K3(1), MAPK14(1), NFATC1(9), NFATC2(8), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6)	2362721	41	27	41	21	13	18	0	8	2	0	0.61	1.00	1.00
528	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(3), G6PD(2), GCLM(2), GGT1(8), GPX1(1), GPX3(1), GPX4(3), GSS(1), GSTA1(2), GSTA2(1), GSTA4(1), GSTM1(1), GSTM3(1), GSTM4(1), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(3), IDH1(1), IDH2(1), MGST1(2), MGST2(1), MGST3(1), PGD(1)	3558156	43	27	42	16	16	14	1	11	1	0	0.40	1.00	1.00
529	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), G6PD(2), GPI(4), H6PD(3), PFKL(7), PFKM(3), PFKP(8), PGD(1), PGLS(2), PGM1(3), PGM3(6), PRPS1(1), PRPS1L1(2), PRPS2(3), TALDO1(2), TKTL1(4), TKTL2(5)	4796632	67	27	67	28	22	25	3	14	3	0	0.48	1.00	1.00
530	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22RA1(1), IL22RA2(1), JAK1(4), JAK2(8), JAK3(3), SOCS3(3), STAT1(6), STAT3(7), STAT5A(1), STAT5B(4), TYK2(6)	3623192	46	27	46	19	11	17	1	10	6	1	0.68	1.00	1.00
531	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(5), CBS(3), CTH(2), DNMT1(12), DNMT3A(7), DNMT3B(7), MARS(3), MARS2(1), MAT1A(3), MAT2B(1), MTR(9)	3430793	53	27	53	30	21	16	2	11	3	0	0.92	1.00	1.00
532	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(4), BLVRA(2), CP(5), CPOX(1), EPRS(6), FECH(5), GUSB(3), HCCS(1), HMOX1(3), PPOX(2), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2B15(1), UGT2B4(2), UROD(1), UROS(3)	5424189	44	27	44	24	7	18	1	12	6	0	0.95	1.00	1.00
533	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), GOT1(2), GOT2(3), GPT(1), GPT2(3), MDH1(3), MDH2(1), ME1(3), ME2(4), ME3(5), PGK1(1), PKLR(4), PKM2(2), TPI1(2)	3558642	45	26	44	18	17	11	3	11	3	0	0.59	1.00	1.00
534	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(7), POLE(14), POLG(4), POLL(1), POLQ(14)	3296060	40	26	40	25	12	10	1	10	7	0	0.98	1.00	1.00
535	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(5), GUSB(3), UGDH(4), UGP2(1), UGT1A1(1), UGT1A5(3), UGT1A7(1), UGT2A1(2), UGT2A3(5), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), XYLB(5)	5195234	42	26	42	18	8	18	1	10	5	0	0.69	1.00	1.00
536	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(1), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT4(3), FUT1(2), FUT4(1), FUT7(1), FUT9(3), GCNT2(2), ST3GAL6(2), ST8SIA1(4)	3165155	33	26	32	16	11	9	1	11	1	0	0.83	1.00	1.00
537	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), GOT1(2), GOT2(3), GPT(1), GPT2(3), MDH1(3), MDH2(1), ME1(3), ME3(5), PGK1(1), PGK2(1), PKLR(4), PKM2(2), TKTL1(4), TKTL2(5), TPI1(2)	3980363	51	26	50	24	19	14	4	12	2	0	0.78	1.00	1.00
538	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(4), ELK1(2), GRB2(1), IL2(1), IL2RA(1), IL2RG(3), JAK1(4), JAK3(3), JUN(2), LCK(1), MAP2K1(4), MAPK3(1), MAPK8(4), RAF1(6), SHC1(3), SOS1(4), STAT5A(1), STAT5B(4), SYK(3)	4610106	52	26	51	19	9	21	1	13	7	1	0.55	1.00	1.00
539	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(2), CD3E(3), CD3G(2), CD4(3), IFNG(2), IL12B(2), IL12RB1(4), IL12RB2(5), JAK2(8), STAT4(4), TYK2(6)	2899352	42	26	41	17	5	16	3	10	8	0	0.75	1.00	1.00
540	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(5), DNMT1(12), MTNR1A(3), MTNR1B(2), PTAFR(2), PTGDR(5), PTGER2(2), PTGER4(1), PTGFR(3), TBXA2R(7)	2179935	42	26	42	22	15	12	3	10	2	0	0.79	1.00	1.00
541	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), GBA3(1), LPO(2), MPO(5), PRDX6(1), TPO(13), TYR(5)	1904516	31	26	31	17	11	6	0	11	3	0	0.93	1.00	1.00
542	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(3), IKBKB(3), JUN(2), LTA(2), MAP2K3(1), MAP2K4(5), MAP2K6(2), MAP3K1(8), MAP3K14(3), MAP4K2(4), MAPK14(1), MAPK8(4), NFKB1(5), RELA(2), TANK(2), TNF(2), TNFRSF1A(3), TRAF2(2)	4745563	54	26	54	21	15	17	1	14	7	0	0.59	1.00	1.00
543	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(3), C9orf95(1), CD38(2), ENPP1(1), ENPP3(3), NADK(3), NADSYN1(5), NMNAT1(1), NMNAT2(1), NMNAT3(1), NNMT(2), NNT(7), NT5C(1), NT5C1A(1), NT5C1B(4), NT5C2(5), NUDT12(1)	4251738	42	25	42	24	13	15	2	8	3	1	0.93	1.00	1.00
544	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(7), GRB2(1), IL3(1), IL3RA(4), JAK2(8), MAP2K1(4), MAPK3(1), PTPN6(3), RAF1(6), SHC1(3), SOS1(4), STAT5A(1), STAT5B(4)	3498185	47	25	47	18	13	18	1	9	6	0	0.56	1.00	1.00
545	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(4), EPX(4), LPO(2), MPO(5), PRDX6(1), SHMT1(1), SHMT2(4), TPO(13)	2326526	35	25	35	14	11	6	2	10	6	0	0.62	1.00	1.00
546	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(2), CDK5R1(1), DAB1(6), FYN(5), LRP8(3), RELN(21), VLDLR(3)	2783276	41	25	41	20	10	16	1	9	5	0	0.84	1.00	1.00
547	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(4), CD44(5), FCGR3A(1), IL1B(1), SELL(4), TGFB1(3), TGFB2(6), TNF(2), TNFRSF1A(3), TNFRSF1B(1), TNFRSF8(2), TNFSF8(1)	2613615	33	25	33	16	10	10	0	8	5	0	0.66	1.00	1.00
548	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6(1), JAK1(4), JAK2(8), JAK3(3), PIAS3(1), PTPRU(13), REG1A(4), STAT3(7)	3009862	43	25	43	15	13	13	0	13	3	1	0.47	1.00	1.00
549	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(3), CD3G(2), CD8A(2), ICAM1(2), ITGAL(7), ITGB2(6), PTPRC(16)	2128359	40	25	38	18	11	10	1	12	6	0	0.80	1.00	1.00
550	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(2), CSF1R(7), EGF(5), EGFR(10), GRB2(1), MET(4), PDGFRA(4), SH3GLB1(1), SH3GLB2(3), SH3KBP1(5)	3843415	42	24	42	32	16	9	2	7	8	0	0.99	1.00	1.00
551	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(11), ADRB2(4), CFTR(3), GNAS(14), PRKACB(2), PRKACG(3), PRKAR1A(2), PRKAR1B(1), PRKAR2A(1), PRKAR2B(6)	2580035	47	24	46	17	19	18	0	7	3	0	0.44	1.00	1.00
552	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(2), BCAT2(1), IARS(7), IARS2(3), ILVBL(3), LARS(3), LARS2(5), PDHA1(1), PDHA2(4), PDHB(2), VARS(8), VARS2(4)	3680181	43	24	43	15	13	10	2	14	4	0	0.55	1.00	1.00
553	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP2(3), ACP5(2), ACP6(3), ACPP(3), ACPT(1), ALPI(4), ALPL(3), ALPP(5), ALPPL2(4), CYP3A4(1), CYP3A43(3), CYP3A5(1), CYP3A7(2), DHRS3(1), DHRS7(1), DHRSX(2), PON1(1), PON2(2)	3543969	42	24	41	17	16	14	1	5	6	0	0.48	1.00	1.00
554	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(4), B3GALNT1(2), B3GALT5(1), FUT1(2), FUT9(3), HEXA(1), HEXB(3), NAGA(3), ST3GAL1(3), ST3GAL2(4), ST8SIA1(4)	2127305	30	24	30	12	11	5	2	11	1	0	0.69	1.00	1.00
555	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(5), ICAM1(2), ITGA4(8), ITGAL(7), ITGB1(4), ITGB2(6), SELE(3), SELL(4)	2407931	39	24	38	17	13	8	2	10	6	0	0.63	1.00	1.00
556	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(3), FUCA1(1), FUCA2(2), GLB1(3), HEXA(1), HEXB(3), LCT(11), MAN2C1(4), MANBA(2), NEU1(1), NEU2(2), NEU3(2), NEU4(2)	3250755	37	24	37	20	17	9	0	6	5	0	0.91	1.00	1.00
557	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(4), ALDOC(3), FBP1(1), FBP2(3), G6PD(2), GPI(4), H6PD(3), PFKM(3), PFKP(8), PGD(1), PGLS(2), PGM1(3), PGM3(6), PRPS1(1), PRPS1L1(2), PRPS2(3), TAL1(1), TALDO1(2)	4028005	52	24	52	23	17	17	2	13	3	0	0.62	1.00	1.00
558	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(3), CD3G(2), CD4(3), FYN(5), HLA-DRA(3), HLA-DRB1(1), LCK(1), PTPRC(16), ZAP70(4)	1786448	38	24	36	19	7	12	1	13	5	0	0.91	1.00	1.00
559	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), GBA(4), GBA3(1), LPO(2), MPO(5), PRDX6(1), TPO(13)	1660878	30	23	30	13	13	7	0	8	2	0	0.69	1.00	1.00
560	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPL10L(5), RPL12(1), RPL13(1), RPL13A(1), RPL14(1), RPL18A(1), RPL19(2), RPL23A(1), RPL27A(1), RPL3(2), RPL31(1), RPL34(1), RPL36A(1), RPL6(1), RPL8(2), RPL9(2), RPS10(1), RPS11(1), RPS13(1), RPS20(1), RPS23(1), RPS3(1), RPS3A(1), RPS5(2), RPS6(1), RPSA(4)	4478789	39	23	39	19	10	17	1	7	4	0	0.89	1.00	1.00
561	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(2), B4GALT2(5), B4GALT3(1), B4GALT5(3), FUT8(3), ST3GAL1(3), ST3GAL2(4), ST3GAL3(2), ST3GAL4(3)	1553428	27	23	26	10	10	8	0	8	1	0	0.59	1.00	1.00
562	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(4), MBTPS1(9), MBTPS2(2), SCAP(7), SREBF1(4), SREBF2(7)	2320505	34	23	34	16	11	13	1	7	2	0	0.68	1.00	1.00
563	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(3), CD3G(2), CD4(3), ICAM1(2), ITGAL(7), ITGB2(6), PTPRC(16)	2234803	41	23	39	21	10	11	1	13	6	0	0.92	1.00	1.00
564	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM2(2), CALM3(1), CCL2(1), CCR5(1), CXCR4(2), GNAQ(1), JUN(2), MAPK14(1), MAPK8(4), PLCG1(10), PTK2B(8)	2728483	34	22	33	13	14	10	0	9	1	0	0.48	1.00	1.00
565	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(3), GALNS(2), GLB1(3), GNS(3), GUSB(3), HEXA(1), HEXB(3), IDS(3), IDUA(1), LCT(11), NAGLU(2)	2824541	35	22	35	19	11	14	1	7	2	0	0.85	1.00	1.00
566	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(4), ABCC2(12), ABCG2(3), BCHE(3), CES1(7), CES2(5), CYP3A4(1), CYP3A5(1), UGT1A1(1), UGT1A5(3), UGT1A7(1)	4535993	41	22	41	22	6	19	2	8	6	0	0.88	1.00	1.00
567	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(2), ITGAL(7), ITGAM(5), ITGB2(6), SELE(3), SELL(4)	2073837	32	22	32	18	14	5	1	7	5	0	0.91	1.00	1.00
568	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(2), CREBBP(13), DFFA(2), DFFB(2), GZMA(2), HMGB2(2), PRF1(1), SET(2)	2089941	26	22	26	11	3	9	2	6	6	0	0.75	1.00	1.00
569	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(5), CCNE1(3), CDC34(1), CDK2(2), CUL1(10), RB1(8), SKP2(4), TFDP1(2)	1701327	35	22	34	15	6	12	1	12	4	0	0.69	1.00	1.00
570	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(2), IL13RA2(7), IL4R(1), JAK1(4), JAK2(8), TYK2(6)	2071061	30	22	30	14	7	8	2	8	4	1	0.84	1.00	1.00
571	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(2), IL13RA2(7), IL4R(1), JAK1(4), JAK2(8), TYK2(6)	2071061	30	22	30	14	7	8	2	8	4	1	0.84	1.00	1.00
572	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(4), JAK2(8), JAK3(3), MAPK1(2), MAPK3(1), STAT3(7), TYK2(6)	2302000	31	22	31	14	5	13	0	8	4	1	0.81	1.00	1.00
573	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(4), ALAS1(2), ALAS2(4), CPO(2), FECH(5), GATA1(2), HBB(1), UROD(1), UROS(3)	1559013	24	21	24	10	7	4	2	9	2	0	0.75	1.00	1.00
574	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	DUSP1(1), IKBKAP(3), IKBKB(3), MAP3K1(8), MAP3K14(3), NFKB1(5), RELA(2), TNFAIP3(5), TRAF3(2), TRAF6(4)	3601882	36	21	36	12	14	7	2	8	5	0	0.52	1.00	1.00
575	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP51A1(3), DHCR24(2), DHCR7(2), EBP(1), FDPS(4), GGCX(1), GGPS1(2), HMGCR(5), HSD17B7(1), IDI2(1), LSS(5), MVD(2), MVK(4), NQO1(3), NSDHL(3), SC4MOL(2), SC5DL(1), SQLE(4), TM7SF2(1), VKORC1(1)	3821478	48	21	47	20	16	11	3	14	4	0	0.76	1.00	1.00
576	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	DUSP1(1), IKBKAP(3), IKBKB(3), LTA(2), MAP3K1(8), MAP3K14(3), NFKB1(5), RELA(2), TANK(2), TNFAIP3(5), TNFRSF1B(1), TRAF1(2), TRAF2(2), TRAF3(2)	4450001	41	21	41	17	17	10	1	8	5	0	0.68	1.00	1.00
577	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(4), ALAS1(2), ALAS2(4), CPOX(1), FECH(5), PPOX(2), UROD(1), UROS(3)	1504399	22	20	22	10	6	4	1	9	2	0	0.84	1.00	1.00
578	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(3), HK1(6), HK2(6), HK3(3), IMPA1(3), ISYNA1(2), PGM1(3), PGM3(6), TGDS(2)	2298043	34	20	34	14	14	13	3	2	2	0	0.37	1.00	1.00
579	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(3), CTH(2), GGT1(8), MARS(3), MARS2(1), MAT1A(3), MAT2B(1), PAPSS1(4), PAPSS2(2), SCLY(1), SEPHS1(1)	2439040	29	20	28	14	10	10	1	5	3	0	0.71	1.00	1.00
580	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(2), CDK5R1(1), EGR1(3), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(1), NGFR(5), RAF1(6)	1610005	25	19	25	15	8	9	1	6	1	0	0.89	1.00	1.00
581	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(5), CCNA2(1), CCND1(1), CCNE1(3), CCNE2(1), CDK2(2), CDKN2A(4), E2F2(2), PRB1(2)	1714247	21	19	21	18	3	8	1	7	2	0	0.99	1.00	1.00
582	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(4), AGT(2), AGTR1(1), AGTR2(1), BDKRB2(3), KNG1(4), NOS3(3), REN(3)	1942346	21	18	21	11	7	7	1	3	3	0	0.71	1.00	1.00
583	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR2(2), ARPC1A(3), ARPC1B(1), ARPC4(1), NCK1(3), NCKAP1(6), NTRK1(4), PSMA7(3), WASF1(4), WASF2(2), WASF3(3), WASL(1)	3016215	34	18	34	28	16	10	1	4	3	0	1.00	1.00	1.00
584	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(3), EGF(5), EGFR(10), HGS(3), RAB5A(2), TF(6), TFRC(1)	2555404	30	18	30	16	5	8	1	11	5	0	0.89	1.00	1.00
585	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(7), FARSA(3), FARSB(1), GOT1(2), GOT2(3), PAH(5), TAT(1), YARS(1), YARS2(1)	1725043	24	18	24	10	8	8	0	6	2	0	0.71	1.00	1.00
586	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), GRB2(1), IL2RG(3), IL4R(1), IRS1(7), JAK1(4), JAK3(3), RPS6KB1(3), SHC1(3)	2924931	27	18	26	19	6	10	0	6	4	1	0.99	1.00	1.00
587	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(3), HDAC9(1), MEF2A(1), MEF2B(3), MEF2C(2), MEF2D(6), MYOD1(3), YWHAH(1)	1559440	21	18	21	11	9	5	2	4	1	0	0.78	1.00	1.00
588	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(3), CD38(2), ENPP1(1), ENPP3(3), NADSYN1(5), NMNAT1(1), NMNAT2(1), NNMT(2), NNT(7), NT5C(1)	2870773	26	18	26	16	5	9	2	7	2	1	0.96	1.00	1.00
589	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(3), DLL1(3), FURIN(2), NOTCH1(15), PSEN1(1)	1794737	24	18	24	17	10	6	1	4	3	0	0.92	1.00	1.00
590	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAP3K14(3), MAPK14(1), MAPK8(4), NFKB1(5), RELA(2), TNFRSF13B(1), TNFRSF17(1), TRAF2(2), TRAF3(2), TRAF6(4)	2878967	25	18	25	10	5	6	1	10	3	0	0.80	1.00	1.00
591	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(2), HLA-DRA(3), HLA-DRB1(1), IFNG(2), IFNGR1(2), IFNGR2(1), IL12B(2), IL12RB1(4), IL12RB2(5), IL18R1(2), IL2(1), IL2RA(1), IL4R(1)	2513517	27	18	27	13	7	8	2	7	3	0	0.71	1.00	1.00
592	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(3), CAPN1(3), CAPNS1(1), CAPNS2(1), CDK5(2), CDK5R1(1), CSNK1D(2), GSK3B(2), MAPT(4), PPP2CA(3)	1836853	22	17	21	13	10	8	0	2	2	0	0.86	1.00	1.00
593	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(9), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(9)	2647352	28	17	28	15	10	11	0	5	2	0	0.84	1.00	1.00
594	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(2), BAD(1), BAK1(2), BCL10(1), BCL2(1), BCL2L11(1), BID(1), CASP8AP2(9), CASP9(1), CES1(7)	2231072	26	17	26	10	8	8	0	9	1	0	0.68	1.00	1.00
595	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(2), UBE2A(2), UBE2B(1), UBE2D3(1), UBE2E3(3), UBE2G2(2), UBE2H(1), UBE2I(2), UBE2J2(3), UBE2L3(1), UBE2L6(1), UBE2N(1), UBE3A(5)	2075177	26	17	26	14	9	7	1	5	4	0	0.78	1.00	1.00
596	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(2), IL13(2), IL16(2), IL2(1), IL3(1), IL6(1), IL8(1), LTA(2), TNF(2)	1974971	20	16	20	10	5	7	1	7	0	0	0.75	1.00	1.00
597	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	CDKN1A(1), EPOR(2), GRIN1(4), HIF1A(2), JAK2(8), NFKB1(5), RELA(2), SOD2(1)	2500547	25	15	25	11	6	8	1	4	6	0	0.79	1.00	1.00
598	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(9), GRHPR(2), HAO1(1), MDH1(3), MDH2(1), MTHFD1(3), MTHFD1L(2), MTHFD2(1)	2532789	22	15	21	13	5	11	1	3	2	0	0.87	1.00	1.00
599	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(9), GRHPR(2), HAO1(1), MDH1(3), MDH2(1), MTHFD1(3), MTHFD1L(2), MTHFD2(1)	2651844	22	15	21	13	5	11	1	3	2	0	0.87	1.00	1.00
600	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(4), ADSS(3), IMPDH1(1), MTHFD2(1), POLD1(7), POLG(4), PRPS2(3), RRM1(4), SRM(1)	2450604	28	15	28	11	8	14	1	3	2	0	0.47	1.00	1.00
601	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(19), RANGAP1(4)	1671751	24	15	22	14	1	10	2	9	2	0	0.92	1.00	1.00
602	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(1), MMP2(4), MMP9(6), RECK(5), TIMP2(1), TIMP3(2)	1483464	19	15	19	12	7	5	0	3	4	0	0.92	1.00	1.00
603	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(2), B3GALT2(5), B3GALT5(1), B3GNT5(1), FUT1(2), ST3GAL3(2), ST3GAL4(3)	1428103	16	14	16	7	8	2	0	6	0	0	0.75	1.00	1.00
604	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(2), BCL2(1), CASP3(1), CASP9(1), CYCS(1), DAXX(3), FAS(3), HSPB1(1), HSPB2(1), MAPKAPK3(3), TNF(2)	2236054	20	14	20	14	8	7	0	3	2	0	0.95	1.00	1.00
605	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), GAD1(3), HDC(5), PNMT(3), TH(1), TPH1(1)	1186592	15	12	15	8	5	4	2	4	0	0	0.81	1.00	1.00
606	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(3), ALDH1A2(5), BCMO1(2), RDH5(2)	770906	12	11	12	11	3	3	0	5	1	0	0.99	1.00	1.00
607	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(3), CD80(1), HLA-DRA(3), HLA-DRB1(1), IL10(1), IL2(1)	791778	10	10	10	6	2	4	0	4	0	0	0.88	1.00	1.00
608	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	EHHADH(2), HADH(2), HADHA(2), HSD17B4(2), NTAN1(2), SIRT1(3), SIRT2(1), SIRT5(3), SIRT7(1), VNN2(1)	2346943	19	10	18	10	3	4	3	4	5	0	0.88	1.00	1.00
609	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(4), AASDH(4), AASS(2), KARS(3)	1384664	13	10	13	9	2	9	1	1	0	0	0.92	1.00	1.00
610	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR2(2), ARPC1A(3), ARPC1B(1), ARPC4(1), CDC42(1), WASF1(4), WASL(1)	1611048	14	9	14	17	6	5	1	1	1	0	1.00	1.00	1.00
611	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(3), CHRNA1(3), SNAP25(1), STX1A(1)	647538	8	8	8	5	3	1	0	4	0	0	0.89	1.00	1.00
612	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(3), PLCD1(1), TGM2(4)	984737	8	8	8	5	6	1	0	1	0	0	0.79	1.00	1.00
613	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(3), HLA-DRA(3), HLA-DRB1(1)	472988	7	7	7	6	1	3	0	3	0	0	0.96	1.00	1.00
614	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(4), RAB27A(3), RAB5A(2), RAB6A(1)	852681	11	7	11	12	2	6	0	2	1	0	0.98	1.00	1.00
615	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(2), ST3GAL3(2)	1007483	4	4	4	6	2	0	0	2	0	0	0.99	1.00	1.00
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		100814	0	0	0	0	0	0	0	0	0	0	1.00	1.00	1.00
