Clinical Features Time to Death AGE HISTOLOGICAL.TYPE RADIATIONS.RADIATION.REGIMENINDICATION NEOADJUVANT.THERAPY nMutated (%) nWild-Type logrank test_P logrank test_Q t-test_P t-test_Q Chi-square test_P Chi-square test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q FBXW7 39 (16%) 209 0.77183 1 0.90403 1 0.047258 1 0.85502 1 0.11692 1 PTEN 161 (65%) 87 0.18985 1 0.027636 1 5.4447e-19 3.26e-16 0.050278 1 0.0015967 0.932 SPOP 21 (8%) 227 0.65037 1 0.52707 1 0.3325 1 0.81063 1 0.45172 1 CTCF 45 (18%) 203 0.40496 1 0.019788 1 0.0020974 1 0.86319 1 1 1 CTNNB1 74 (30%) 174 0.87814 1 0.0017 0.991 1.0411e-05 0.0062 0.3811 1 0.012375 1 KRAS 53 (21%) 195 0.071973 1 0.00027384 0.162 0.0069187 1 0.25333 1 0.0089239 1 PIK3CA 132 (53%) 116 0.054965 1 0.19491 1 0.55455 1 0.59272 1 0.88685 1 PIK3R1 83 (33%) 165 0.87106 1 0.80623 1 0.00082734 0.486 0.39522 1 0.29278 1 PPP2R1A 27 (11%) 221 0.12058 1 0.037446 1 0.0097696 1 0.52048 1 0.11228 1 PRKAR1B 4 (2%) 244 0.70228 1 0.97808 1 0.96118 1 0.60848 1 1 1 TP53 69 (28%) 179 0.32453 1 6.1488e-06 0.00367 3.9787e-23 2.39e-20 0.37065 1 6.0787e-05 0.0361 FGFR2 31 (12%) 217 0.89974 1 0.99841 1 0.71937 1 1 1 0.38953 1 ARID1A 83 (33%) 165 0.0080038 1 0.0072123 1 0.001265 0.74 0.67274 1 0.023364 1 CHD4 35 (14%) 213 0.36056 1 0.41782 1 0.77947 1 0.56494 1 0.68286 1 NFE2L2 15 (6%) 233 0.90303 1 0.19144 1 0.44715 1 0.58898 1 1 1 P2RY11 9 (4%) 239 0.39537 1 0.39557 1 0.98713 1 0.4973 1 0.70878 1 CCND1 15 (6%) 233 0.72944 1 0.055579 1 0.41271 1 0.39984 1 0.13049 1 SOX17 7 (3%) 241 0.66932 1 0.84797 1 0.0056667 1 0.42754 1 0.67732 1 FOXA2 12 (5%) 236 0.79909 1 0.53126 1 0.97183 1 0.22865 1 1 1 FAM9A 14 (6%) 234 0.37841 1 0.91272 1 0.88964 1 1 1 0.12062 1 DNER 18 (7%) 230 0.74602 1 0.041445 1 0.032379 1 0.43956 1 0.27712 1 SMTNL2 9 (4%) 239 0.47197 1 0.53006 1 0.57917 1 1 1 0.45104 1 RBMX 13 (5%) 235 0.3363 1 0.16061 1 0.40025 1 0.14154 1 0.75579 1 PGR 12 (5%) 236 0.26841 1 0.2284 1 0.010466 1 1 1 0.5203 1 TNFAIP6 12 (5%) 236 0.81918 1 0.30169 1 0.59963 1 1 1 0.74074 1 SGK1 15 (6%) 233 0.92499 1 0.42717 1 0.75911 1 0.15798 1 0.56281 1 PDE8B 16 (6%) 232 0.19594 1 0.13463 1 0.027515 1 1 1 0.56763 1 HPD 7 (3%) 241 0.4296 1 0.053772 1 0.05848 1 1 1 1 1 RPL14 7 (3%) 241 0.53177 1 0.67662 1 0.99105 1 0.42754 1 0.39638 1 TAP1 8 (3%) 240 0.58776 1 0.87698 1 0.34319 1 1 1 0.45193 1 MAX 11 (4%) 237 0.88913 1 0.33592 1 0.40438 1 0.75314 1 0.73208 1 ZNF286A 12 (5%) 236 0.3075 1 0.51789 1 0.0026218 1 0.22865 1 1 1 ABI1 4 (2%) 244 0.663 1 0.034201 1 0.96118 1 0.30207 1 0.3025 1 RASA1 22 (9%) 226 0.1273 1 0.4663 1 0.021079 1 0.63875 1 0.80306 1 NRAS 9 (4%) 239 0.35434 1 0.61642 1 0.028946 1 0.72237 1 0.45104 1 ZNF367 8 (3%) 240 0.44946 1 0.36498 1 0.62783 1 0.12712 1 1 1 ING1 13 (5%) 235 0.37045 1 0.69356 1 0.1781 1 0.14154 1 1 1 MFGE8 4 (2%) 244 0.53335 1 0.12684 1 0.070151 1 1 1 0.3025 1 ZNF267 16 (6%) 232 0.56542 1 0.20743 1 0.027515 1 0.78959 1 1 1 ARID5B 29 (12%) 219 0.64166 1 0.64941 1 0.0086518 1 1 1 0.50787 1 DYRK1A 12 (5%) 236 0.93883 1 0.38638 1 0.5951 1 0.55151 1 1 1 EMB 8 (3%) 240 0.44255 1 0.49728 1 0.00059387 0.35 0.71885 1 0.45193 1 ESR1 11 (4%) 237 0.32905 1 0.31681 1 0.65312 1 0.51833 1 0.1792 1 NAA30 8 (3%) 240 0.56498 1 0.35811 1 0.51789 1 0.71885 1 0.68758 1 CHSY3 10 (4%) 238 0.86163 1 0.0080501 1 0.61965 1 0.73946 1 0.46844 1 SIN3A 21 (8%) 227 0.5738 1 0.25573 1 0.10014 1 0.81063 1 0.60942 1 TPTE 15 (6%) 233 0.27292 1 0.16712 1 0.0064822 1 1 1 0.36883 1 CYLC1 18 (7%) 230 0.19797 1 0.7649 1 0.00060085 0.354 0.31283 1 0.41289 1 MORC4 20 (8%) 228 0.15221 1 0.020393 1 0.62903 1 1 1 0.29524 1 TAB3 18 (7%) 230 0.21951 1 0.10704 1 0.0068609 1 0.61632 1 1 1 UPF3B 16 (6%) 232 0.73489 1 0.80979 1 0.39549 1 0.58789 1 0.077527 1 METTL14 10 (4%) 238 0.35837 1 0.83312 1 0.70659 1 1 1 0.2932 1 C9ORF102 16 (6%) 232 0.24545 1 0.35013 1 0.034331 1 0.58789 1 0.56763 1 RHBDD3 4 (2%) 244 0.58688 1 0.20582 1 0.96118 1 0.60848 1 0.57746 1 SAP30 4 (2%) 244 0.64819 1 0.5699 1 1.3363e-08 7.99e-06 1 1 0.57746 1 C12ORF34 6 (2%) 242 0.5417 1 0.67561 1 0.8974 1 1 1 0.19252 1 FUT4 3 (1%) 245 0.86951 1 0.83741 1 0.01646 1 0.27103 1 0.56381 1 C7ORF60 10 (4%) 238 0.30976 1 0.13557 1 0.70659 1 0.31769 1 0.73193 1 NHSL2 12 (5%) 236 0.99166 1 0.50578 1 0.010466 1 0.75627 1 1 1 ZRANB3 8 (3%) 240 0.32464 1 0.83908 1 0.00098732 0.579 0.45126 1 0.45193 1 GYPB 5 (2%) 243 0.58275 1 0.84273 1 0.14875 1 0.1684 1 1 1 OR4K2 11 (4%) 237 0.30412 1 0.24121 1 0.0065848 1 1 1 0.49933 1 KIF26B 19 (8%) 229 0.76809 1 0.40342 1 0.053969 1 0.4597 1 0.29419 1 ZNF263 8 (3%) 240 0.45161 1 0.2191 1 0.80912 1 1 1 0.22012 1 DCAF4 4 (2%) 244 0.61125 1 0.077862 1 0.32759 1 1 1 1 1 PSMG4 5 (2%) 243 0.61886 1 0.77781 1 0.00044115 0.261 0.66303 1 0.3268 1 TWF1 8 (3%) 240 0.43712 1 0.88848 1 0.20497 1 0.27002 1 1 1 OR52I2 8 (3%) 240 0.73072 1 0.55881 1 0.080196 1 0.45126 1 0.45193 1 SERHL2 6 (2%) 242 0.46424 1 0.66613 1 0.8974 1 0.18502 1 0.667 1 UBE2QL1 5 (2%) 243 0.75305 1 0.16266 1 0.93292 1 0.34211 1 1 1 ZNF649 14 (6%) 234 0.24568 1 0.28829 1 0.18198 1 0.77685 1 1 1 OR5D13 10 (4%) 238 0.89523 1 0.74105 1 0.18792 1 0.31769 1 0.46844 1 CHEK2 13 (5%) 235 0.89133 1 0.016332 1 0.030706 1 1 1 0.35217 1 CSDE1 21 (8%) 227 0.80172 1 0.29373 1 0.04351 1 1 1 0.45172 1 FMR1 16 (6%) 232 0.30447 1 0.64302 1 0.068786 1 0.58789 1 0.077527 1 HLA-B 4 (2%) 244 0.52329 1 0.51972 1 0.078009 1 0.30207 1 0.3025 1 IGFBP7 6 (2%) 242 0.40572 1 0.65939 1 0.22793 1 0.66719 1 0.667 1 OR4D2 3 (1%) 245 0.64819 1 0.69296 1 0.98148 1 0.27103 1 0.56381 1 HIST1H2AG 7 (3%) 241 0.54155 1 0.41621 1 0.99105 1 0.048456 1 1 1 CNPY1 7 (3%) 241 0.44861 1 0.18001 1 0.29403 1 1 1 0.67732 1 CABP1 8 (3%) 240 0.31894 1 0.28485 1 0.80912 1 0.71885 1 0.45193 1 CTXN3 6 (2%) 242 0.51233 1 0.79436 1 0.54838 1 1 1 0.19252 1 OR4A15 13 (5%) 235 0.21303 1 0.16688 1 0.0021875 1 1 1 0.75579 1 FAM122A 6 (2%) 242 0.59932 1 0.93596 1 0.22793 1 0.41521 1 0.667 1 TXNDC8 6 (2%) 242 0.43929 1 0.46023 1 0.31998 1 0.66719 1 1 1 OR5AS1 10 (4%) 238 0.67547 1 0.50298 1 0.39585 1 0.50133 1 0.73193 1 ZNF334 17 (7%) 231 0.94995 1 0.023178 1 0.78701 1 1 1 0.41468 1 C12ORF4 13 (5%) 235 0.28714 1 0.16902 1 0.0025945 1 1 1 0.75579 1 GNB2 6 (2%) 242 0.55558 1 0.38792 1 0.22793 1 0.66719 1 1 1 ZNF69 7 (3%) 241 0.51364 1 0.016293 1 0.00014665 0.087 1 1 0.39638 1 CABLES1 6 (2%) 242 0.42494 1 0.10977 1 0.8974 1 1 1 1 1 KLHL8 12 (5%) 236 0.36172 1 0.50443 1 0.40421 1 1 1 1 1 LOC642587 7 (3%) 241 0.67908 1 0.5481 1 0.29403 1 1 1 0.67732 1 RAB3GAP1 16 (6%) 232 0.98049 1 0.59602 1 0.35008 1 1 1 0.7735 1 DAPP1 8 (3%) 240 0.56796 1 0.46186 1 0.34319 1 0.71885 1 0.68758 1 DST 39 (16%) 209 0.46739 1 0.65534 1 0.30142 1 0.46395 1 0.56344 1 HHIPL1 6 (2%) 242 0.67883 1 0.89216 1 0.31998 1 0.41521 1 0.667 1 PAPD4 13 (5%) 235 0.98223 1 0.18054 1 0.96208 1 0.37758 1 0.049153 1 ANKRD31 17 (7%) 231 0.19994 1 0.96423 1 4.8694e-05 0.029 0.43234 1 1 1 LUC7L2 8 (3%) 240 0.33173 1 0.72769 1 0.34319 1 0.27002 1 0.45193 1 MAP3K1 21 (8%) 227 0.096162 1 0.81274 1 0.19974 1 1 1 0.45172 1 PPM1N 7 (3%) 241 0.35463 1 0.79027 1 0.29403 1 1 1 1 1 ZNF879 13 (5%) 235 0.33975 1 0.092598 1 0.40025 1 1 1 1 1 TAF1 35 (14%) 213 0.23113 1 0.83665 1 0.015787 1 0.44767 1 0.84061 1 KCNH2 10 (4%) 238 0.43165 1 0.59741 1 0.33826 1 0.095895 1 0.14288 1 XPA 7 (3%) 241 0.16887 1 0.90033 1 0.9807 1 0.2356 1 0.092006 1 ZNF645 10 (4%) 238 0.35256 1 0.8793 1 0.052659 1 1 1 0.2932 1 ZNF449 12 (5%) 236 0.3546 1 0.94993 1 0.65509 1 0.55151 1 0.5203 1 EDN1 4 (2%) 244 0.72888 1 0.74108 1 0.96118 1 0.60848 1 1 1 GIPC2 9 (4%) 239 0.85074 1 0.041974 1 0.37632 1 0.4973 1 0.70878 1 IGFN1 13 (5%) 235 0.71252 1 0.30718 1 0.29622 1 0.37758 1 0.75579 1 C14ORF118 15 (6%) 233 0.26844 1 0.013762 1 0.36903 1 0.58898 1 0.76579 1 TBC1D12 9 (4%) 239 0.47928 1 0.6037 1 0.75899 1 1 1 1 1 BRS3 15 (6%) 233 0.18418 1 0.1332 1 0.024963 1 0.39984 1 0.76579 1 NFE2L3 12 (5%) 236 0.33584 1 0.65554 1 0.34226 1 0.11468 1 0.74074 1 RRAS2 4 (2%) 244 0.75232 1 0.07173 1 0.96118 1 0.60848 1 0.063936 1 G3BP2 9 (4%) 239 0.40123 1 0.10135 1 0.0008789 0.516 0.4973 1 0.70878 1 CLIC2 10 (4%) 238 0.29358 1 0.85506 1 0.0023104 1 1 1 0.73193 1 OPRK1 7 (3%) 241 0.59445 1 0.54167 1 0.85571 1 0.69387 1 0.67732 1 OR8B8 7 (3%) 241 0.52371 1 0.033869 1 0.29403 1 0.42754 1 1 1