Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.09 0.163 -9999.0 0.0 -0.541 4.0 4.0 IHH -0.137 0.184 -9999.0 0.0 -0.371 19.0 19.0 SHH Np/Cholesterol/GAS1 -0.043 0.087 -9999.0 0.0 -0.183 14.0 14.0 LRPAP1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.043 0.086 0.182 14.0 -9999.0 0.0 14.0 SMO/beta Arrestin2 -0.104 0.186 -9999.0 0.0 -0.336 17.0 17.0 SMO -0.124 0.182 -9999.0 0.0 -0.339 19.0 19.0 AKT1 -0.059 0.154 -9999.0 0.0 -0.513 4.0 4.0 ARRB2 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.018 0.032 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.122 0.18 -9999.0 0.0 -0.341 18.0 18.0 STIL -0.065 0.146 0.177 4.0 -0.275 12.0 16.0 DHH N/PTCH2 0.042 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.072 0.122 -9999.0 0.0 -0.226 19.0 19.0 PIK3CA 0.02 0.052 -9999.0 0.0 -0.353 1.0 1.0 DHH 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.128 0.198 -9999.0 0.0 -0.527 6.0 6.0 determination of left/right symmetry -0.122 0.18 -9999.0 0.0 -0.341 18.0 18.0 PIK3R1 -0.0 0.09 -9999.0 0.0 -0.353 3.0 3.0 skeletal system development -0.127 0.196 -9999.0 0.0 -0.465 9.0 9.0 IHH N/Hhip -0.105 0.143 -9999.0 0.0 -0.264 21.0 21.0 DHH N/Hhip -0.001 0.093 -9999.0 0.0 -0.248 6.0 6.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.122 0.18 -9999.0 0.0 -0.341 18.0 18.0 pancreas development -0.025 0.121 -9999.0 0.0 -0.352 6.0 6.0 HHAT -0.027 0.128 -9999.0 0.0 -0.353 7.0 7.0 PI3K 0.013 0.088 -9999.0 0.0 -0.315 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.05 0.141 -9999.0 0.0 -0.353 9.0 9.0 somite specification -0.122 0.18 -9999.0 0.0 -0.341 18.0 18.0 SHH Np/Cholesterol/PTCH1 -0.086 0.129 -9999.0 0.0 -0.248 18.0 18.0 SHH Np/Cholesterol/PTCH2 -0.007 0.07 -9999.0 0.0 -0.182 7.0 7.0 SHH Np/Cholesterol/Megalin -0.009 0.071 -9999.0 0.0 -0.186 7.0 7.0 SHH -0.015 0.075 -9999.0 0.0 -0.248 5.0 5.0 catabolic process -0.097 0.127 -9999.0 0.0 -0.252 20.0 20.0 SMO/Vitamin D3 -0.092 0.174 0.194 2.0 -0.313 17.0 19.0 SHH Np/Cholesterol/Hhip -0.032 0.09 -9999.0 0.0 -0.198 11.0 11.0 LRP2 0.022 0.027 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.088 0.175 -9999.0 0.0 -0.323 15.0 15.0 SHH Np/Cholesterol/BOC -0.006 0.067 -9999.0 0.0 -0.185 6.0 6.0 SHH Np/Cholesterol/CDO -0.009 0.071 -9999.0 0.0 -0.186 7.0 7.0 mesenchymal cell differentiation 0.032 0.09 0.197 11.0 -9999.0 0.0 11.0 mol:Vitamin D3 -0.072 0.144 0.191 3.0 -0.285 12.0 15.0 IHH N/PTCH2 -0.064 0.114 -9999.0 0.0 -0.227 16.0 16.0 CDON 0.024 0.023 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.089 0.135 -9999.0 0.0 -0.254 20.0 20.0 Megalin/LRPAP1 0.035 0.026 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.012 0.065 -9999.0 0.0 -0.179 7.0 7.0 PTCH1 -0.097 0.128 -9999.0 0.0 -0.253 20.0 20.0 HHIP -0.025 0.121 -9999.0 0.0 -0.353 6.0 6.0