Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	9.0	479.0	52.0	-0.137	0.043	1000.0	-1000.0	-0.02	-1000.0
HIF-1-alpha transcription factor network	8.0	649.0	76.0	-0.268	0.034	1000.0	-1000.0	-0.022	-1000.0
Ephrin B reverse signaling	8.0	400.0	48.0	-0.225	0.03	1000.0	-1000.0	-0.021	-1000.0
PLK2 and PLK4 events	6.0	20.0	3.0	-0.05	0.022	1000.0	-1000.0	-0.003	-1000.0
TCGA08_retinoblastoma	6.0	49.0	8.0	-0.039	0.022	1000.0	-1000.0	-0.005	-1000.0
IGF1 pathway	6.0	356.0	57.0	-0.066	0.051	1000.0	-1000.0	-0.026	-1000.0
FOXM1 transcription factor network	6.0	350.0	51.0	-0.428	0.03	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	6.0	537.0	78.0	-0.235	0.089	1000.0	-1000.0	-0.043	-1000.0
Osteopontin-mediated events	5.0	197.0	38.0	-0.101	0.03	1000.0	-1000.0	-0.018	-1000.0
Noncanonical Wnt signaling pathway	5.0	143.0	26.0	-0.081	0.03	1000.0	-1000.0	-0.029	-1000.0
IL4-mediated signaling events	5.0	486.0	91.0	-0.577	0.387	1000.0	-1000.0	-0.089	-1000.0
Glypican 1 network	5.0	266.0	48.0	-0.061	0.032	1000.0	-1000.0	-0.019	-1000.0
Nectin adhesion pathway	5.0	345.0	63.0	-0.088	0.064	1000.0	-1000.0	-0.028	-1000.0
Endothelins	5.0	572.0	96.0	-0.168	0.038	1000.0	-1000.0	-0.026	-1000.0
IL23-mediated signaling events	5.0	342.0	60.0	-0.327	0.03	1000.0	-1000.0	-0.049	-1000.0
Plasma membrane estrogen receptor signaling	5.0	504.0	86.0	-0.16	0.151	1000.0	-1000.0	-0.033	-1000.0
IL12-mediated signaling events	4.0	380.0	87.0	-0.263	0.051	1000.0	-1000.0	-0.044	-1000.0
TCGA08_p53	4.0	29.0	7.0	-0.038	0.022	1000.0	-1000.0	-0.005	-1000.0
Wnt signaling	4.0	33.0	7.0	-0.076	0.025	1000.0	-1000.0	-0.011	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	339.0	68.0	-0.205	0.122	1000.0	-1000.0	-0.058	-1000.0
Caspase cascade in apoptosis	3.0	267.0	74.0	-0.041	0.041	1000.0	-1000.0	-0.027	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	463.0	136.0	-0.427	0.07	1000.0	-1000.0	-0.032	-1000.0
Syndecan-1-mediated signaling events	3.0	104.0	34.0	-0.089	0.04	1000.0	-1000.0	-0.024	-1000.0
Thromboxane A2 receptor signaling	3.0	339.0	105.0	-0.093	0.048	1000.0	-1000.0	-0.029	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	208.0	65.0	-0.33	0.071	1000.0	-1000.0	-0.019	-1000.0
BMP receptor signaling	3.0	255.0	81.0	-0.103	0.05	1000.0	-1000.0	-0.019	-1000.0
FAS signaling pathway (CD95)	3.0	157.0	47.0	-0.086	0.037	1000.0	-1000.0	-0.035	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	170.0	44.0	-0.068	0.03	1000.0	-1000.0	-0.022	-1000.0
EPHB forward signaling	3.0	298.0	85.0	-0.082	0.055	1000.0	-1000.0	-0.051	-1000.0
Glypican 2 network	3.0	15.0	4.0	-0.009	-0.0	1000.0	-1000.0	-0.0	-1000.0
Nongenotropic Androgen signaling	3.0	180.0	52.0	-0.102	0.048	1000.0	-1000.0	-0.018	-1000.0
LPA receptor mediated events	3.0	316.0	102.0	-0.099	0.03	1000.0	-1000.0	-0.035	-1000.0
Syndecan-4-mediated signaling events	3.0	202.0	67.0	-0.064	0.041	1000.0	-1000.0	-0.028	-1000.0
VEGFR1 specific signals	3.0	182.0	56.0	-0.057	0.03	1000.0	-1000.0	-0.031	-1000.0
Coregulation of Androgen receptor activity	2.0	215.0	76.0	-0.126	0.051	1000.0	-1000.0	-0.011	-1000.0
Visual signal transduction: Cones	2.0	83.0	38.0	-0.015	0.046	1000.0	-1000.0	-0.001	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	36.0	17.0	-0.038	0.047	1000.0	-1000.0	-0.016	-1000.0
Syndecan-2-mediated signaling events	2.0	140.0	69.0	-0.038	0.044	1000.0	-1000.0	-0.033	-1000.0
Cellular roles of Anthrax toxin	2.0	115.0	39.0	-0.057	0.03	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by PTP1B	2.0	181.0	76.0	-0.078	0.042	1000.0	-1000.0	-0.032	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	147.0	61.0	-0.09	0.061	1000.0	-1000.0	-0.027	-1000.0
FOXA2 and FOXA3 transcription factor networks	2.0	117.0	46.0	-0.169	0.036	1000.0	-1000.0	-0.067	-1000.0
Fc-epsilon receptor I signaling in mast cells	2.0	247.0	97.0	-0.077	0.045	1000.0	-1000.0	-0.043	-1000.0
PDGFR-alpha signaling pathway	2.0	116.0	44.0	-0.136	0.04	1000.0	-1000.0	-0.029	-1000.0
mTOR signaling pathway	2.0	117.0	53.0	-0.019	0.036	1000.0	-1000.0	-0.028	-1000.0
IFN-gamma pathway	2.0	161.0	68.0	-0.045	0.041	1000.0	-1000.0	-0.037	-1000.0
Ceramide signaling pathway	2.0	161.0	76.0	-0.048	0.069	1000.0	-1000.0	-0.021	-1000.0
Reelin signaling pathway	2.0	158.0	56.0	-0.046	0.049	1000.0	-1000.0	-0.025	-1000.0
TRAIL signaling pathway	2.0	110.0	48.0	-0.02	0.035	1000.0	-1000.0	-0.023	-1000.0
IL1-mediated signaling events	2.0	144.0	62.0	-0.052	0.066	1000.0	-1000.0	-0.026	-1000.0
S1P5 pathway	2.0	40.0	17.0	-0.025	0.028	1000.0	-1000.0	-0.006	-1000.0
ceramide signaling pathway	2.0	132.0	49.0	-0.038	0.044	1000.0	-1000.0	-0.027	-1000.0
HIF-2-alpha transcription factor network	2.0	111.0	43.0	-0.054	0.055	1000.0	-1000.0	-0.027	-1000.0
S1P1 pathway	2.0	96.0	36.0	-0.106	0.028	1000.0	-1000.0	-0.031	-1000.0
Retinoic acid receptors-mediated signaling	2.0	152.0	58.0	-0.101	0.059	1000.0	-1000.0	-0.025	-1000.0
Syndecan-3-mediated signaling events	2.0	72.0	35.0	-0.06	0.059	1000.0	-1000.0	-0.018	-1000.0
IL2 signaling events mediated by PI3K	2.0	137.0	58.0	-0.101	0.032	1000.0	-1000.0	-0.024	-1000.0
Integrins in angiogenesis	2.0	209.0	84.0	-0.089	0.06	1000.0	-1000.0	-0.028	-1000.0
TCR signaling in naïve CD8+ T cells	2.0	217.0	93.0	-0.033	0.041	1000.0	-1000.0	-0.029	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	104.0	45.0	-0.038	0.046	1000.0	-1000.0	-0.031	-1000.0
Canonical Wnt signaling pathway	2.0	139.0	51.0	-0.09	0.072	1000.0	-1000.0	-0.026	-1000.0
IL27-mediated signaling events	2.0	142.0	51.0	-0.107	0.054	1000.0	-1000.0	-0.035	-1000.0
IL6-mediated signaling events	2.0	199.0	75.0	-0.078	0.058	1000.0	-1000.0	-0.043	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	160.0	74.0	-0.06	0.055	1000.0	-1000.0	-0.047	-1000.0
IL2 signaling events mediated by STAT5	2.0	47.0	22.0	-0.071	0.037	1000.0	-1000.0	-0.027	-1000.0
Class I PI3K signaling events	2.0	162.0	73.0	-0.029	0.042	1000.0	-1000.0	-0.023	-1000.0
BCR signaling pathway	2.0	201.0	99.0	-0.038	0.056	1000.0	-1000.0	-0.037	-1000.0
Visual signal transduction: Rods	2.0	108.0	52.0	-0.079	0.066	1000.0	-1000.0	-0.019	-1000.0
E-cadherin signaling in keratinocytes	2.0	100.0	43.0	-0.029	0.045	1000.0	-1000.0	-0.023	-1000.0
S1P4 pathway	2.0	62.0	25.0	-0.027	0.04	1000.0	-1000.0	-0.015	-1000.0
Regulation of Androgen receptor activity	2.0	206.0	70.0	-0.145	0.035	1000.0	-1000.0	-0.029	-1000.0
Aurora B signaling	2.0	163.0	67.0	-0.06	0.042	1000.0	-1000.0	-0.026	-1000.0
LPA4-mediated signaling events	1.0	22.0	12.0	-0.027	0.008	1000.0	-1000.0	-0.019	-1000.0
ErbB2/ErbB3 signaling events	1.0	68.0	65.0	-0.043	0.067	1000.0	-1000.0	-0.044	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	1.0	66.0	34.0	-0.023	0.075	1000.0	-1000.0	-0.022	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	34.0	28.0	-0.025	0.04	1000.0	-1000.0	-0.009	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	1.0	80.0	54.0	-0.037	0.042	1000.0	-1000.0	-0.021	-1000.0
Ephrin A  reverse signaling	1.0	8.0	7.0	-0.002	0.035	1000.0	-1000.0	-0.0	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	7.0	5.0	0.012	0.029	1000.0	-1000.0	0.015	-1000.0
Arf6 signaling events	1.0	95.0	62.0	-0.008	0.048	1000.0	-1000.0	-0.008	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	126.0	85.0	-0.133	0.057	1000.0	-1000.0	-0.037	-1000.0
Aurora A signaling	1.0	68.0	60.0	-0.023	0.062	1000.0	-1000.0	-0.01	-1000.0
p75(NTR)-mediated signaling	1.0	229.0	125.0	-0.09	0.065	1000.0	-1000.0	-0.046	-1000.0
EPO signaling pathway	1.0	95.0	55.0	-0.073	0.039	1000.0	-1000.0	-0.022	-1000.0
PLK1 signaling events	1.0	130.0	85.0	-0.034	0.032	1000.0	-1000.0	-0.028	-1000.0
amb2 Integrin signaling	1.0	156.0	82.0	-0.029	0.067	1000.0	-1000.0	-0.023	-1000.0
Glucocorticoid receptor regulatory network	1.0	197.0	114.0	-0.138	0.078	1000.0	-1000.0	-0.045	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	55.0	37.0	-0.029	0.051	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by HDAC Class III	1.0	68.0	40.0	-0.055	0.055	1000.0	-1000.0	-0.032	-1000.0
Signaling events regulated by Ret tyrosine kinase	1.0	88.0	82.0	-0.02	0.05	1000.0	-1000.0	-0.042	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	79.0	52.0	-0.057	0.069	1000.0	-1000.0	-0.021	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	102.0	83.0	-0.032	0.055	1000.0	-1000.0	-0.011	-1000.0
FoxO family signaling	1.0	77.0	64.0	-0.042	0.039	1000.0	-1000.0	-0.028	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	28.0	15.0	-0.027	0.028	1000.0	-1000.0	-0.029	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	47.0	36.0	-0.04	0.055	1000.0	-1000.0	-0.022	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	46.0	31.0	-0.038	0.04	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	226.0	125.0	-0.026	0.051	1000.0	-1000.0	-0.022	-1000.0
TCGA08_rtk_signaling	1.0	27.0	26.0	-0.035	0.042	1000.0	-1000.0	-0.005	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	119.0	76.0	-0.03	0.059	1000.0	-1000.0	-0.038	-1000.0
Regulation of Telomerase	1.0	125.0	102.0	-0.066	0.061	1000.0	-1000.0	-0.025	-1000.0
EGFR-dependent Endothelin signaling events	1.0	39.0	21.0	-0.003	0.041	1000.0	-1000.0	-0.014	-1000.0
Insulin Pathway	1.0	127.0	74.0	-0.045	0.063	1000.0	-1000.0	-0.025	-1000.0
S1P3 pathway	1.0	67.0	42.0	-0.032	0.04	1000.0	-1000.0	-0.023	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	175.0	120.0	-0.035	0.082	1000.0	-1000.0	-0.029	-1000.0
PDGFR-beta signaling pathway	1.0	165.0	97.0	-0.049	0.061	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	0.016	0.045	1000.0	-1000.0	0.015	-1000.0
p38 MAPK signaling pathway	1.0	55.0	44.0	-0.051	0.052	1000.0	-1000.0	-0.013	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	33.0	17.0	-0.017	0.046	1000.0	-1000.0	-0.018	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	21.0	23.0	-0.002	0.039	1000.0	-1000.0	-0.016	-1000.0
Canonical NF-kappaB pathway	0.0	21.0	39.0	-0.009	0.067	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by HDAC Class II	0.0	60.0	75.0	-0.066	0.07	1000.0	-1000.0	-0.024	-1000.0
ErbB4 signaling events	0.0	38.0	69.0	-0.036	0.055	1000.0	-1000.0	-0.025	-1000.0
BARD1 signaling events	0.0	51.0	57.0	-0.057	0.069	1000.0	-1000.0	-0.032	-1000.0
Circadian rhythm pathway	0.0	6.0	22.0	-0.01	0.059	1000.0	-1000.0	-0.022	-1000.0
Arf6 downstream pathway	0.0	24.0	43.0	-0.041	0.054	1000.0	-1000.0	-0.024	-1000.0
Aurora C signaling	0.0	5.0	7.0	-0.0	0.039	1000.0	-1000.0	-0.009	-1000.0
Insulin-mediated glucose transport	0.0	24.0	32.0	-0.003	0.037	1000.0	-1000.0	-0.012	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	52.0	68.0	-0.044	0.058	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by HDAC Class I	0.0	70.0	104.0	-0.035	0.069	1000.0	-1000.0	-0.023	-1000.0
Atypical NF-kappaB pathway	0.0	24.0	31.0	-0.0	0.031	1000.0	-1000.0	-0.011	-1000.0
Regulation of p38-alpha and p38-beta	0.0	53.0	54.0	-0.023	0.069	1000.0	-1000.0	-0.019	-1000.0
Effects of Botulinum toxin	0.0	7.0	26.0	-0.004	0.045	1000.0	-1000.0	-0.002	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	12.0	27.0	-0.016	0.068	1000.0	-1000.0	-0.028	-1000.0
Arf6 trafficking events	0.0	23.0	71.0	-0.05	0.053	1000.0	-1000.0	-0.022	-1000.0
Angiopoietin receptor Tie2-mediated signaling	0.0	84.0	88.0	-0.045	0.049	1000.0	-1000.0	-0.055	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	27.0	33.0	-0.045	0.067	1000.0	-1000.0	-0.023	-1000.0
Rapid glucocorticoid signaling	0.0	8.0	20.0	-0.003	0.037	1000.0	-1000.0	-0.001	-1000.0
Signaling events mediated by PRL	0.0	25.0	34.0	-0.03	0.043	1000.0	-1000.0	-0.03	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.03	0.03	1000.0	-1000.0	-0.02	-1000.0
Arf1 pathway	0.0	14.0	54.0	-0.001	0.052	1000.0	-1000.0	-0.01	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	0.0	0.07	1000.0	-1000.0	0.0	-1000.0
Total	265	18626	7203	-9.69067792645	6.74494951519	131000	-131000	-3.28570992801	-131000