rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(8), CDKN2A(2), E2F1(9), MDM2(4), MYC(8), PIK3CA(172), PIK3R1(100), POLR1A(16), POLR1B(16), POLR1C(2), POLR1D(3), RAC1(1), RB1(26), TBX2(2), TP53(74), TWIST1(1)	7247552	444	223	300	50	87	115	119	6	99	18	3.94e-10	<1.00e-15	<1.43e-14
2	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(4), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), EIF4E(2), GSK3B(13), IGF1(5), IGF1R(13), INPPL1(19), PDK2(5), PDPK1(3), PIK3CA(172), PIK3R1(100), PPP2CA(6), PTEN(227), RPS6(7), RPS6KB1(5)	7335096	603	217	388	46	79	131	117	40	194	42	<1.00e-15	<1.00e-15	<1.43e-14
3	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(5), CRK(2), CRKL(6), DOCK1(24), ELK1(3), FOS(3), GAB1(8), GRB2(3), HGF(14), HRAS(1), ITGA1(17), ITGB1(8), JUN(1), MAP2K1(2), MAP2K2(5), MAP4K1(11), MAPK1(2), MAPK3(3), MAPK8(10), MET(17), PAK1(3), PIK3CA(172), PIK3R1(100), PTEN(227), PTK2(12), PTK2B(16), PTPN11(8), PXN(6), RAF1(8), RAP1A(4), RAP1B(2), RASA1(30), SOS1(13), SRC(3), STAT3(10)	17110264	759	217	538	93	134	188	148	37	208	44	3.89e-15	<1.00e-15	<1.43e-14
4	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(4), EIF4A1(5), EIF4A2(9), EIF4E(2), EIF4G1(15), EIF4G2(7), EIF4G3(24), GHR(8), IRS1(13), MAPK1(2), MAPK14(4), MAPK3(3), MKNK1(3), PABPC1(11), PDK2(5), PDPK1(3), PIK3CA(172), PIK3R1(100), PRKCA(10), PTEN(227), RPS6KB1(5)	10435840	632	216	418	49	91	134	133	39	191	44	<1.00e-15	<1.00e-15	<1.43e-14
5	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(4), BCAR1(8), CDKN1B(7), GRB2(3), ILK(5), ITGB1(8), MAPK1(2), MAPK3(3), PDK2(5), PDPK1(3), PIK3CA(172), PIK3R1(100), PTEN(227), PTK2(12), SHC1(7), SOS1(13)	7174392	579	213	364	30	72	121	124	37	183	42	<1.00e-15	<1.00e-15	<1.43e-14
6	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT1(4), AKT2(6), AKT3(11), BCR(6), BTK(12), CD19(4), CDKN2A(2), DAPP1(9), FLOT2(2), GAB1(8), ITPR1(36), ITPR2(35), ITPR3(21), LYN(9), NR0B2(2), PDK1(2), PHF11(5), PIK3CA(172), PITX2(12), PLCG2(29), PPP1R13B(9), PREX1(25), PTEN(227), PTPRC(17), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KB1(5), SAG(10), SYK(4), TEC(8), VAV1(12)	20541344	738	212	540	128	147	231	144	38	149	29	5.04e-10	<1.00e-15	<1.43e-14
7	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(3), AKT1(4), AKT2(6), AKT3(11), BAD(2), BTK(12), CDKN2A(2), DAPP1(9), GRB2(3), GSK3A(10), GSK3B(13), IARS(8), IGFBP1(4), INPP5D(9), PDK1(2), PIK3CA(172), PPP1R13B(9), PTEN(227), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KB1(5), SHC1(7), SOS1(13), SOS2(17), TEC(8), YWHAE(4), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1)	13352320	602	211	404	65	112	161	131	37	133	28	1.22e-15	<1.00e-15	<1.43e-14
8	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(4), APC(56), AXIN1(9), CCND1(15), CD14(2), CTNNB1(80), DVL1(3), FZD1(3), GJA1(5), GNAI1(5), GSK3B(13), IRAK1(4), LBP(3), LEF1(9), LY96(4), MYD88(3), NFKB1(10), PDPK1(3), PIK3CA(172), PIK3R1(100), PPP2CA(6), RELA(6), TIRAP(2), TLR4(17), TOLLIP(1), WNT1(1)	11218032	536	210	356	58	77	201	122	6	110	20	9.76e-14	<1.00e-15	<1.43e-14
9	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	ACTA1(5), AGT(8), AKT1(4), CALM1(2), CALM2(4), CALR(3), CAMK1(2), CAMK1G(5), CAMK4(5), CREBBP(32), CSNK1A1(4), EDN1(4), ELSPBP1(5), F2(8), FKBP1A(1), GATA4(3), GSK3B(13), HAND1(6), HRAS(1), IGF1(5), LIF(3), MAP2K1(2), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(10), MEF2C(11), MYH2(43), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NKX2-5(2), NPPA(2), PIK3CA(172), PIK3R1(100), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RAF1(8), RPS6KB1(5), SYT1(4)	18646128	575	207	445	97	126	176	137	5	113	18	3.38e-08	<1.00e-15	<1.43e-14
10	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(4), BAD(2), BCL2L1(4), CBL(12), CFLAR(6), CRKL(6), E2F1(9), FOS(3), GRB2(3), HRAS(1), IL2RA(4), IL2RB(3), IL2RG(13), IRS1(13), JAK1(20), JAK3(10), MAPK1(2), MAPK3(3), MYC(8), NMI(3), PIK3CA(172), PIK3R1(100), PPIA(1), PTPN6(6), RAF1(8), RPS6KB1(5), SHC1(7), SOS1(13), STAT5A(5), STAT5B(7), SYK(4)	13344136	457	203	334	55	84	140	122	5	91	15	1.67e-10	<1.00e-15	<1.43e-14
11	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(4), CABIN1(19), CALM1(2), CALM2(4), CAMK1(2), CAMK1G(5), HDAC5(12), IGF1(5), IGF1R(13), INS(3), INSR(18), MAP2K6(10), MAPK14(4), MAPK7(14), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), NFATC1(10), NFATC2(13), PIK3CA(172), PIK3R1(100), PPP3CA(4), PPP3CB(5), PPP3CC(6), SYT1(4), YWHAH(3)	12782416	454	202	331	72	109	116	116	8	90	15	2.14e-07	<1.00e-15	<1.43e-14
12	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), INS(3), INSR(18), IRS1(13), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(10), PIK3CA(172), PIK3R1(100), PTPN11(8), RAF1(8), RASA1(30), SHC1(7), SLC2A4(9), SOS1(13), SRF(3)	9476328	419	202	292	39	82	118	108	5	90	16	2.40e-13	<1.00e-15	<1.43e-14
13	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(4), AKT2(6), AKT3(11), BAD(2), GRB2(3), GSK3A(10), GSK3B(13), IL4R(6), IRS1(13), JAK1(20), JAK3(10), MAP4K1(11), MAPK1(2), MAPK3(3), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3R1(100), PPP1R13B(9), RAF1(8), SHC1(7), SOS1(13), SOS2(17), STAT6(10)	13137552	464	202	337	55	106	123	119	5	95	16	8.06e-11	<1.00e-15	<1.43e-14
14	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(2), CALM2(4), CD3D(6), CD3E(2), CD3G(3), ELK1(3), FOS(3), FYN(7), GRB2(3), HRAS(1), JUN(1), LCK(5), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(10), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NFKB1(10), NFKBIA(3), PIK3CA(172), PIK3R1(100), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKCA(10), PTPN7(6), RAC1(1), RAF1(8), RASA1(30), RELA(6), SHC1(7), SOS1(13), SYT1(4), VAV1(12), ZAP70(9)	17583448	554	202	424	83	118	164	129	5	121	17	7.81e-09	<1.00e-15	<1.43e-14
15	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(21), AKT1(4), ASAH1(7), GNAI1(5), GNB1(2), GNGT1(1), ITGAV(10), ITGB3(11), MAPK1(2), MAPK3(3), PDGFA(3), PDGFRA(24), PIK3CA(172), PIK3R1(100), PLCB1(5), PRKCA(10), PTK2(12), RAC1(1), SMPD1(11), SMPD2(7), SPHK1(2), SRC(3)	10175192	416	201	295	65	72	117	114	6	90	17	0.000012	<1.00e-15	<1.43e-14
16	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), JAK1(20), JUN(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(10), PDGFA(3), PDGFRA(24), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), RAF1(8), RASA1(30), SHC1(7), SOS1(13), SRF(3), STAT1(15), STAT3(10), STAT5A(5)	13057448	506	201	375	56	94	144	134	4	112	18	3.58e-12	<1.00e-15	<1.43e-14
17	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(21), AKT1(4), BAD(2), BAX(3), BCL2L1(4), CSF2RB(14), IGF1(5), IGF1R(13), IL3(2), IL3RA(9), KIT(24), KITLG(3), PIK3CA(172), PIK3R1(100), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), YWHAH(3)	8125224	406	200	286	52	74	120	107	6	83	16	3.08e-09	<1.00e-15	<1.43e-14
18	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(21), AKT1(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CREB1(6), GNAS(24), GRB2(3), HRAS(1), MAPK1(2), MAPK14(4), MAPK3(3), PIK3CA(172), PIK3R1(100), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), RAC1(1), RPS6KA1(1), RPS6KA5(11), SOS1(13)	10761216	425	200	300	54	88	113	111	5	92	16	4.42e-08	<1.00e-15	<1.43e-14
19	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), IGF1(5), IGF1R(13), IRS1(13), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(10), PIK3CA(172), PIK3R1(100), PTPN11(8), RAF1(8), RASA1(30), SHC1(7), SOS1(13), SRF(3)	9176744	407	200	280	36	72	117	108	5	89	16	3.39e-13	<1.00e-15	<1.43e-14
20	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(32), EP300(32), FYN(7), IL2RG(13), IL7(1), IL7R(12), JAK1(20), JAK3(10), LCK(5), NMI(3), PIK3CA(172), PIK3R1(100), PTK2B(16), STAT5A(5), STAT5B(7)	10514456	435	200	312	56	77	121	115	6	100	16	3.19e-08	<1.00e-15	<1.43e-14
21	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CDK5(2), CDK5R1(3), CFL1(1), CHN1(3), LIMK1(8), MAP3K1(30), MYL2(2), MYLK(14), NCF2(8), PAK1(3), PDGFRA(24), PIK3CA(172), PIK3R1(100), PLD1(14), PPP1R12B(20), RAC1(1), RALBP1(6), RPS6KB1(5), TRIO(34), VAV1(12), WASF1(3)	13103576	466	200	341	66	88	134	115	6	104	19	1.27e-07	<1.00e-15	<1.43e-14
22	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(4), BAD(2), CASP9(3), CHUK(8), GH1(3), GHR(8), NFKB1(10), NFKBIA(3), PDPK1(3), PIK3CA(172), PIK3R1(100), PPP2CA(6), RELA(6), YWHAH(3)	5298520	331	199	212	19	49	93	92	4	78	15	3.56e-13	<1.00e-15	<1.43e-14
23	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(21), DIAPH1(13), FYN(7), GSN(5), HRAS(1), ITGA1(17), ITGB1(8), MAP2K1(2), MAPK1(2), MAPK3(3), MYL2(2), MYLK(14), PFN1(1), PIK3CA(172), PIK3R1(100), PTK2(12), PXN(6), RAF1(8), ROCK1(22), SHC1(7), SRC(3), TLN1(23)	14251072	449	199	329	53	93	128	116	4	91	17	4.23e-10	<1.00e-15	<1.43e-14
24	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(9), EGF(20), EGFR(12), ELK1(3), FOS(3), GRB2(3), HRAS(1), JAK1(20), JUN(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(10), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), RAF1(8), RASA1(30), SHC1(7), SOS1(13), SRF(3), STAT1(15), STAT3(10), STAT5A(5)	13971080	511	199	380	61	99	144	131	4	116	17	5.32e-11	<1.00e-15	<1.43e-14
25	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(4), CREB1(6), GRB2(3), HRAS(1), MAPK1(2), MAPK3(3), MAPK7(14), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), NTRK1(13), PIK3CA(172), PIK3R1(100), PLCG1(12), RPS6KA1(1), SHC1(7)	7425864	360	199	240	37	64	100	96	6	79	15	1.28e-09	<1.00e-15	<1.43e-14
26	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(12), CALM1(2), CALM2(4), ELK1(3), FCER1A(9), FCER1G(2), FOS(3), GRB2(3), HRAS(1), JUN(1), LYN(9), MAP2K1(2), MAP2K4(9), MAP2K7(4), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8(10), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), PAK2(3), PIK3CA(172), PIK3R1(100), PLA2G4A(13), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), RAF1(8), SHC1(7), SOS1(13), SYK(4), SYT1(4), VAV1(12)	15708816	514	199	386	78	103	160	124	6	105	16	1.64e-07	<1.00e-15	<1.43e-14
27	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(4), BCR(6), CRKL(6), FOS(3), GRB2(3), HRAS(1), JAK2(17), JUN(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(10), MYC(8), PIK3CA(172), PIK3R1(100), RAF1(8), SOS1(13), STAT1(15), STAT5A(5), STAT5B(7)	10234960	423	199	298	39	75	122	113	4	90	19	9.63e-13	<1.00e-15	<1.43e-14
28	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(21), ARHGEF1(12), F2(8), F2R(6), GNA12(8), GNA13(7), GNAI1(5), GNAQ(3), GNB1(2), GNGT1(1), MAP3K7(9), PIK3CA(172), PIK3R1(100), PLCB1(5), PPP1R12B(20), PRKCA(10), PTK2B(16), ROCK1(22)	9538576	427	199	304	63	96	111	112	7	84	17	2.55e-06	<1.00e-15	<1.43e-14
29	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(7), AKT1(4), ANXA1(5), CALM1(2), CALM2(4), GNAS(24), GNB1(2), GNGT1(1), NFKB1(10), NOS3(11), NPPA(2), NR3C1(18), PIK3CA(172), PIK3R1(100), RELA(6), SYT1(4)	6660784	372	197	249	26	79	99	91	4	84	15	1.54e-13	<1.00e-15	<1.43e-14
30	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(4), BAD(2), BCL2L1(4), CASP9(3), CDC42(4), CHUK(8), ELK1(3), H2AFX(1), HRAS(1), MAP2K1(2), MAPK3(3), NFKB1(10), PIK3CA(172), PIK3R1(100), RAC1(1), RAF1(8), RALA(6), RALBP1(6), RALGDS(9), RELA(6), RHOA(3)	7368576	356	197	235	28	56	106	95	4	78	17	2.25e-12	<1.00e-15	<1.43e-14
31	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	DUSP1(2), GORASP1(9), IKBKG(4), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(10), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(5), MAPKAPK5(5), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), PIK3CA(172), PIK3CD(12), PIK3R1(100), SYT1(4), TRAF2(3), TRAF3(5), TRAF5(7), TRAF6(7)	12579552	430	197	310	59	91	116	104	4	99	16	1.03e-08	<1.00e-15	<1.43e-14
32	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(4), DPM2(2), GRB2(3), HRAS(1), KLK2(2), NTRK1(13), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), SHC1(7), SOS1(13)	5821304	339	197	216	32	54	97	95	4	74	15	1.05e-08	<1.00e-15	<1.43e-14
33	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(5), EIF1(1), EIF2B2(5), EIF2B3(7), EIF2B4(4), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), ELAVL1(8), FLT1(20), FLT4(9), HIF1A(16), HRAS(1), KDR(26), NOS3(11), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), PTK2(12), PXN(6), SHC1(7), VHL(3)	12967672	457	197	334	58	94	128	110	7	103	15	8.97e-10	<1.00e-15	<1.43e-14
34	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(8), CRK(2), CXCL12(6), CXCR4(1), GNAI1(5), GNAQ(3), GNB1(2), GNGT1(1), HRAS(1), MAP2K1(2), MAPK1(2), MAPK3(3), NFKB1(10), PIK3C2G(16), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), PTK2(12), PTK2B(16), PXN(6), RAF1(8), RELA(6)	10504536	404	196	282	58	82	109	108	4	86	15	1.37e-06	<1.00e-15	<1.43e-14
35	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(4), BAD(2), GRB2(3), HRAS(1), IGF1R(13), IRS1(13), MAP2K1(2), MAPK1(2), MAPK3(3), PIK3CA(172), PIK3R1(100), RAF1(8), SHC1(7), SOS1(13), YWHAH(3)	6997568	346	196	223	34	62	91	97	5	76	15	3.14e-09	<1.00e-15	<1.43e-14
36	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(3), HLA-A(1), IL18(2), ITGB1(8), KLRC1(7), KLRC2(3), KLRC3(1), KLRC4(5), KLRD1(3), MAP2K1(2), MAPK3(3), PAK1(3), PIK3CA(172), PIK3R1(100), PTK2B(16), PTPN6(6), RAC1(1), SYK(4), VAV1(12)	7058328	352	196	232	34	59	99	93	5	81	15	1.94e-09	<1.00e-15	<1.43e-14
37	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(9), FOS(3), GRB2(3), HRAS(1), JAK2(17), JUN(1), MAP2K1(2), MAPK3(3), MPL(7), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), RAF1(8), RASA1(30), SHC1(7), SOS1(13), STAT1(15), STAT3(10), STAT5A(5), STAT5B(7), THPO(7)	11163968	442	196	313	50	83	126	118	4	92	19	1.42e-09	<1.00e-15	<1.43e-14
38	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(6), ACTR3(1), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(4), PAK1(3), PDGFRA(24), PIK3CA(172), PIK3R1(100), RAC1(1), WASL(9)	5033160	334	195	214	16	51	90	92	4	81	16	5.22e-15	<1.00e-15	<1.43e-14
39	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(3), CD3D(6), CD3E(2), CD3G(3), CD80(5), CD86(5), CTLA4(2), GRB2(3), ICOS(3), IL2(2), ITK(7), LCK(5), PIK3CA(172), PIK3R1(100), PTPN11(8)	4525504	326	194	207	19	47	91	88	5	80	15	2.36e-12	<1.00e-15	<1.43e-14
40	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(9), DPM2(2), ELK1(3), FOS(3), GRB2(3), HRAS(1), JUN(1), KLK2(2), MAP2K1(2), MAPK3(3), MAPK8(10), NGFR(3), PIK3CA(172), PIK3R1(100), PLCG1(12), RAF1(8), SHC1(7), SOS1(13)	7010960	354	194	228	24	58	100	101	4	76	15	2.10e-13	<1.00e-15	<1.43e-14
41	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(4), AKT2(6), AKT3(11), CDKN1A(1), ELK1(3), GRB2(3), HRAS(1), MAP2K1(2), MAP2K2(5), NGFR(3), NTRK1(13), PIK3CA(172), PIK3CD(12), SHC1(7), SOS1(13)	6111712	256	151	155	33	59	99	82	3	13	0	5.42e-08	<1.00e-15	<1.43e-14
42	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(3), ARF3(4), CCND1(15), CDK2(2), CDK4(3), CDKN1A(1), CDKN1B(7), CDKN2A(2), CFL1(1), E2F1(9), E2F2(3), MDM2(4), PRB1(2), TP53(74)	3031552	130	99	104	21	35	37	31	1	26	0	0.0020	<1.00e-15	<1.43e-14
43	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(5), MAX(12), MYC(8), SP1(7), SP3(11), TP53(74), WT1(3)	2521168	120	91	91	10	36	32	28	2	22	0	1.22e-06	<1.00e-15	<1.43e-14
44	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(4), AKT2(6), AKT3(11), BPNT1(3), GRB2(3), ILK(5), MAPK1(2), MAPK3(3), PDK1(2), PIK3CA(172), PIK3CD(12), PTEN(227), PTK2B(16), RBL2(19), SHC1(7), SOS1(13)	7530768	505	208	307	39	91	126	107	36	117	28	<1.00e-15	1.11e-15	1.49e-14
45	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(4), CCND1(15), CCNE1(6), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), CDKN1B(7), E2F1(9), HRAS(1), MAPK1(2), MAPK3(3), NFKB1(10), NFKBIA(3), PAK1(3), PIK3CA(172), PIK3R1(100), RAC1(1), RAF1(8), RB1(26), RELA(6), TFDP1(13)	7607400	398	202	274	38	67	107	108	4	94	18	3.72e-11	1.11e-15	1.49e-14
46	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(4), PIK3CA(172), PIK3R1(100), PLCB1(5), PLCG1(12), PRKCA(10), VAV1(12)	4836496	315	194	195	39	51	75	91	7	76	15	0.000074	1.11e-15	1.49e-14
47	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(4), EIF4A1(5), EIF4A2(9), EIF4B(7), EIF4E(2), EIF4G1(15), EIF4G2(7), EIF4G3(24), FKBP1A(1), MKNK1(3), PDK2(5), PDPK1(3), PIK3CA(172), PIK3R1(100), PPP2CA(6), PTEN(227), RPS6(7), RPS6KB1(5), TSC1(13), TSC2(15)	10458408	630	218	417	44	90	141	126	38	191	44	<1.00e-15	1.22e-15	1.57e-14
48	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(54), ATR(35), CDC25C(5), CHEK1(2), CHEK2(14), TP53(74), YWHAH(3)	5915544	187	101	159	19	41	59	41	1	42	3	0.000078	1.22e-15	1.57e-14
49	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(4), CAT(4), GH1(3), GHR(8), HRAS(1), IGF1(5), IGF1R(13), PIK3CA(172), PIK3R1(100), SHC1(7), SOD1(2), SOD2(3)	4873696	322	195	203	28	53	83	91	5	75	15	1.48e-09	1.33e-15	1.67e-14
50	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	47	AKT1(4), AKT2(6), AKT3(11), BRD4(10), CAP1(7), CBL(12), CDC42(4), CDKN2A(2), F2RL2(2), FLOT2(2), GRB2(3), GSK3A(10), GSK3B(13), IGFBP1(4), INPPL1(19), IRS1(13), IRS4(21), LNPEP(10), MAPK1(2), MAPK3(3), PARD3(19), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3R1(100), PPYR1(8), PTEN(227), PTPN1(5), RAF1(8), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KB1(5), SERPINB6(3), SHC1(7), SLC2A4(9), SORBS1(18), SOS1(13), SOS2(17), YWHAE(4), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1)	21082232	829	217	605	120	160	197	174	40	214	44	5.04e-12	1.44e-15	1.78e-14
51	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(4), BAD(2), CHRNB1(2), CHRNG(4), MUSK(15), PIK3CA(172), PIK3R1(100), PTK2(12), PTK2B(16), RAPSN(2), SRC(3), TERT(4), YWHAH(3)	6316064	339	197	220	43	57	93	94	4	76	15	1.82e-06	2.00e-15	2.41e-14
52	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(3), GHR(8), GRB2(3), HRAS(1), INS(3), INSR(18), IRS1(13), JAK2(17), MAP2K1(2), MAPK1(2), MAPK3(3), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), PTPN6(6), RAF1(8), RPS6KA1(1), SHC1(7), SLC2A4(9), SOS1(13), SRF(3), STAT5A(5), STAT5B(7)	12267816	426	197	302	59	93	114	115	5	81	18	1.86e-07	2.11e-15	2.50e-14
53	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(4), CREB1(6), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K6(10), MAP3K1(30), MAPK1(2), MAPK14(4), MAPK3(3), NFKB1(10), PIK3CA(172), PIK3R1(100), RB1(26), RELA(6), SP1(7)	7413960	394	200	272	31	63	112	107	4	89	19	1.14e-12	2.89e-15	3.35e-14
54	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(8), DNAJC3(9), EIF2S1(2), EIF2S2(9), MAP3K14(6), NFKB1(10), NFKBIA(3), RELA(6), TP53(74)	3802584	127	84	100	10	32	39	26	3	27	0	1.85e-06	3.66e-15	4.18e-14
55	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(7), APOA1(3), APOA2(2), CD36(8), CPT1B(6), CREBBP(32), DUSP1(2), EHHADH(11), EP300(32), FABP1(4), HSD17B4(13), INS(3), JUN(1), LPL(16), MAPK1(2), MAPK3(3), ME1(12), MRPL11(1), MYC(8), NCOA1(19), NCOR1(23), NCOR2(23), NFKBIA(3), NR0B2(2), NR1H3(4), NR2F1(7), NRIP1(17), PDGFA(3), PIK3CA(172), PIK3R1(100), PPARA(1), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), PTGS2(9), RB1(26), RELA(6), RXRA(3), SP1(7), SRA1(1), STAT5A(5), STAT5B(7)	23447904	641	204	514	103	136	194	160	8	122	21	5.47e-10	1.18e-13	1.32e-12
56	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(54), CDC25A(8), CDC25B(3), CDC25C(5), CDK2(2), CDK4(3), CHEK1(2), MYT1(18), RB1(26), TP53(74), WEE1(2), YWHAH(3)	6664008	200	105	170	24	53	59	41	1	40	6	0.000024	1.31e-11	1.44e-10
57	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(17), ATM(54), ATR(35), BAI1(10), BAX(3), BBC3(2), BID(2), CASP3(4), CASP8(21), CASP9(3), CCNB1(8), CCNB2(5), CCNB3(33), CCND1(15), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNG1(9), CCNG2(2), CD82(5), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(14), CYCS(2), DDB2(6), EI24(3), FAS(9), GADD45G(1), GTSE1(2), IGF1(5), IGFBP3(4), MDM2(4), MDM4(5), PERP(3), PMAIP1(1), PPM1D(13), PTEN(227), RCHY1(5), RFWD2(4), RRM2(7), RRM2B(5), SERPINB5(1), SERPINE1(5), SESN1(5), SESN2(3), SESN3(15), SIAH1(6), STEAP3(9), THBS1(11), TNFRSF10B(5), TP53(74), TP53I3(4), TP73(6), TSC2(15), ZMAT3(11)	24384104	758	226	627	133	132	229	132	34	198	33	3.40e-08	2.01e-10	2.17e-09
58	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(4), ASAH1(7), ATF1(6), BRAF(10), CAMP(1), CREB1(6), CREB5(5), CREBBP(32), CRKL(6), DAG1(6), EGR1(6), EGR2(6), EGR3(7), EGR4(5), ELK1(3), FRS2(5), GNAQ(3), JUN(1), MAP1B(35), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(9), MAPK3(3), MAPK8(10), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(5), NTRK1(13), OPN1LW(6), PIK3C2G(16), PIK3CA(172), PIK3CD(12), PIK3R1(100), PTPN11(8), RPS6KA3(19), SHC1(7), SRC(3), TERF2IP(2), TH(3)	19360368	572	205	447	103	130	184	126	5	109	18	7.69e-08	4.51e-10	4.79e-09
59	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(4), AKT2(6), AKT3(11), BRAF(10), CAB39(6), DDIT4(2), EIF4B(7), FIGF(5), HIF1A(16), IGF1(5), INS(3), MAPK1(2), MAPK3(3), PDPK1(3), PGF(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PRKAA1(8), PRKAA2(10), RHEB(3), RICTOR(21), RPS6(7), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA6(19), RPS6KB1(5), RPS6KB2(4), STK11(2), TSC1(13), TSC2(15), ULK1(5), ULK2(12), ULK3(5), VEGFA(2), VEGFB(2), VEGFC(6)	20076344	609	207	479	97	139	179	150	5	121	15	1.57e-08	1.19e-09	1.24e-08
60	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(4), AKT2(6), AKT3(11), BAD(2), BCL2L1(4), CDC42(4), CDK2(2), CDKN1B(7), CDKN2A(2), CREB1(6), CREB5(5), EBP(2), ERBB4(27), F2RL2(2), GAB1(8), GRB2(3), GSK3A(10), GSK3B(13), IGF1(5), IGFBP1(4), INPPL1(19), IRS1(13), IRS4(21), MET(17), MYC(8), NOLC1(14), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PARD3(19), PDK1(2), PIK3CA(172), PIK3CD(12), PPP1R13B(9), PREX1(25), PTEN(227), PTK2(12), PTPN1(5), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KB1(5), SHC1(7), SLC2A4(9), SOS1(13), SOS2(17), TSC1(13), TSC2(15), YWHAE(4), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1)	27949352	863	216	660	148	188	253	185	41	166	30	9.72e-12	1.03e-07	1.06e-06
61	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(6), ACTR3(1), AKT1(4), AKT2(6), AKT3(11), ANGPTL2(6), ARHGAP1(2), ARHGAP4(11), ARHGEF11(20), BTK(12), CDC42(4), CFL1(1), CFL2(8), GDI1(4), GDI2(1), INPPL1(19), ITPR1(36), ITPR2(35), ITPR3(21), LIMK1(8), MYLK(14), MYLK2(8), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3CG(23), PIK3R1(100), PITX2(12), PPP1R13B(9), PTEN(227), RACGAP1(9), RHO(4), ROCK1(22), ROCK2(17), RPS4X(1), SAG(10), WASF1(3), WASL(9)	26400096	906	219	684	159	174	270	164	38	216	44	2.89e-09	1.18e-07	1.19e-06
62	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(17), ATM(54), BAX(3), CCND1(15), CCNE1(6), CDK2(2), CDK4(3), CDKN1A(1), E2F1(9), MDM2(4), PCNA(3), RB1(26), TIMP3(9), TP53(74)	6807848	226	117	195	34	48	71	52	1	48	6	0.00025	3.40e-06	0.000034
63	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(6), CDK2(2), CUL1(13), E2F1(9), FBXW7(46), RB1(26), TFDP1(13)	3205400	115	60	97	17	45	31	17	1	17	4	0.00015	0.000011	0.00011
64	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(56), AXIN1(9), BTRC(14), CCND1(15), CREBBP(32), CSNK1A1(4), CSNK1D(3), CSNK2A1(9), CTBP1(1), CTNNB1(80), DVL1(3), FZD1(3), GSK3B(13), HDAC1(5), MAP3K7(9), MYC(8), NLK(5), PPARD(3), PPP2CA(6), TLE1(13), WIF1(5), WNT1(1)	11032528	297	132	230	50	65	138	47	2	41	4	6.88e-06	0.000027	0.00026
65	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(32), DAXX(10), HRAS(1), PAX3(5), PML(8), RARA(2), RB1(26), SIRT1(6), SP100(20), TNFRSF1A(4), TNFRSF1B(2), TP53(74)	6803136	190	99	162	31	59	55	34	2	36	4	0.000084	0.000033	0.00031
66	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(6), ACTR3(1), AKT1(4), ANGPTL2(6), DAG1(6), DGKA(10), ETFA(5), GCA(2), ITGA9(16), ITPKA(1), ITPKB(12), ITPR1(36), ITPR2(35), ITPR3(21), MAP2K1(2), MAPK1(2), MAPK3(3), NR1I3(6), PAK1(3), PDE3A(19), PDE3B(15), PI3(2), PIK3C2G(16), PIK3CA(172), PIK3CD(12), PIK3R1(100), PLDN(3), PSME1(1), RIPK3(5), RPS4X(1), SGCB(4), VASP(3)	18620336	530	204	407	104	113	164	121	6	110	16	0.000057	0.00091	0.0085
67	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(54), ATR(35), BRCA1(17), BRCA2(58), CHEK1(2), CHEK2(14), FANCA(15), FANCC(9), FANCD2(11), FANCE(9), FANCF(1), FANCG(10), HUS1(3), MRE11A(10), RAD1(6), RAD17(13), RAD50(17), RAD51(2), RAD9A(2), TP53(74)	16461744	362	118	330	46	75	147	72	1	62	5	2.37e-07	0.0022	0.020
68	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(4), AKT2(6), AKT3(11), CISH(2), GRB2(3), IARS(8), IL13RA1(13), IL2RG(13), IL4(1), IL4R(6), INPP5D(9), JAK1(20), JAK2(17), JAK3(10), NR0B2(2), PI3(2), PIK3CA(172), PPP1R13B(9), RPS6KB1(5), SERPINA4(4), SHC1(7), SOS1(13), SOS2(17), SRC(3), STAT6(10), TYK2(10)	13739696	377	155	276	71	79	142	111	6	35	4	0.000047	0.0061	0.055
69	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(4), APC(56), AR(14), ASAH1(7), BRAF(10), CAMP(1), CCL13(2), CCL15(1), CCL16(1), DAG1(6), EGFR(12), GNA11(2), GNA15(2), GNAI1(5), GNAQ(3), ITPKA(1), ITPKB(12), ITPR1(36), ITPR2(35), ITPR3(21), KCNJ3(9), KCNJ5(7), KCNJ9(4), MAPK1(2), MAPK10(9), MAPK14(4), PHKA2(21), PIK3CA(172), PIK3CD(12), PIK3R1(100), PITX2(12), PTX3(2), RAF1(8), SRC(3)	20171328	596	210	468	121	123	197	131	7	117	21	0.000027	0.0084	0.075
70	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(5), IMPA1(4), IMPA2(6), INPP1(3), INPP4A(21), INPP4B(16), INPP5A(5), INPP5B(5), INPP5E(1), INPPL1(19), IPMK(4), ISYNA1(2), ITPK1(4), ITPKA(1), ITPKB(12), MINPP1(3), MIOX(6), OCRL(19), PI4KA(18), PI4KB(9), PIK3C3(14), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIP4K2A(5), PIP4K2B(7), PIP4K2C(3), PIP5K1A(8), PIP5K1B(5), PIP5K1C(5), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(5), PLCD3(3), PLCD4(11), PLCE1(41), PLCG1(12), PLCG2(29), PLCZ1(14), PTEN(227), PTPMT1(2), SYNJ1(29), SYNJ2(11)	27875200	861	213	660	167	205	234	181	41	172	28	7.04e-09	0.018	0.16
71	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(4), AKT2(6), AKT3(11), BAD(2), BCR(6), BLNK(4), BTK(12), CD19(4), CSK(1), DAG1(6), EPHB2(12), GRB2(3), ITPKA(1), ITPKB(12), LYN(9), MAP2K1(2), MAP2K2(5), MAPK1(2), NFAT5(16), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), PI3(2), PIK3CA(172), PIK3CD(12), PIK3R1(100), PLCG2(29), PPP1R13B(9), RAF1(8), SERPINA4(4), SHC1(7), SOS1(13), SOS2(17), SYK(4), VAV1(12)	19440224	536	202	409	109	119	170	128	6	97	16	0.00021	0.034	0.29
72	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(14), AKT1(4), AKT2(6), AKT3(11), APAF1(17), ATM(54), BAD(2), BAX(3), BCL2L1(4), BID(2), BIRC2(10), BIRC3(5), CAPN1(5), CAPN2(11), CASP10(8), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CFLAR(6), CHUK(8), CSF2RB(14), CYCS(2), DFFB(4), ENDOG(1), FADD(1), FAS(9), FASLG(7), IKBKB(13), IKBKG(4), IL1B(2), IL1R1(5), IL1RAP(8), IL3(2), IL3RA(9), IRAK1(4), IRAK2(9), IRAK3(10), IRAK4(7), MAP3K14(6), MYD88(3), NFKB1(10), NFKB2(9), NFKBIA(3), NTRK1(13), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRKACA(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RELA(6), RIPK1(9), TNFRSF10A(2), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(6), TNFRSF1A(4), TNFSF10(1), TP53(74), TRAF2(3)	31533448	880	230	720	163	185	298	188	7	182	20	7.77e-09	0.17	1.00
73	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(3)	187984	3	3	3	1	0	1	0	1	1	0	0.81	0.19	1.00
74	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(5), IL8(3), SLPI(2)	635128	10	10	9	0	2	5	2	0	1	0	0.057	0.32	1.00
75	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(8)	268832	8	6	8	1	2	4	2	0	0	0	0.30	0.33	1.00
76	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(8), ATM(54), ATR(35), CCNA1(5), CCND1(15), CCNE1(6), CDC25A(8), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), CDKN1B(7), CDKN2A(2), DHFR(4), E2F1(9), GSK3B(13), HDAC1(5), RB1(26), SKP2(7), TFDP1(13), TGFB1(2), TGFB2(5), TGFB3(9), TP53(74)	11008224	316	132	284	65	82	99	60	1	68	6	0.0037	0.37	1.00
77	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(8), ATM(54), BRCA1(17), CDKN1A(1), CHEK1(2), CHEK2(14), JUN(1), MAPK8(10), MDM2(4), MRE11A(10), NFKB1(10), NFKBIA(3), RAD50(17), RAD51(2), RBBP8(11), RELA(6), TP53(74), TP73(6)	10888936	250	112	222	46	54	84	53	1	54	4	0.0062	0.41	1.00
78	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(6), CD3E(2), CD3G(3)	437720	11	7	11	1	1	7	0	0	3	0	0.18	0.41	1.00
79	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(5), IFNG(9), IFNGR1(5), IFNGR2(4), IKBKB(13), JAK2(17), LIN7A(8), NFKB1(10), NFKBIA(3), RB1(26), RELA(6), TNFRSF1A(4), TNFRSF1B(2), TP53(74), USH1C(13), WT1(3)	6563568	202	96	177	43	54	65	39	2	35	7	0.011	0.42	1.00
80	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(6), CSF1(6), IL6(5), LDLR(6), LPL(16)	1950272	39	23	39	7	10	15	9	0	5	0	0.057	0.42	1.00
81	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(4), CD34(1), CD3D(6), CD3E(2), CD3G(3), CD4(6), CD58(2), CD8A(2), CSF3(1), IL3(2), IL6(5), IL8(3), KITLG(3)	2324752	40	27	40	9	6	20	4	0	10	0	0.18	0.42	1.00
82	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(6), CDK2(2), CDKN1B(7), CKS1B(1), CUL1(13), E2F1(9), RB1(26), RBX1(1), SKP2(7), TFDP1(13)	3255992	85	39	83	17	27	25	17	0	13	3	0.027	0.44	1.00
83	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(4), APAF1(17), ATM(54), BAD(2), BAX(3), BCL2L1(4), BID(2), CASP3(4), CASP6(7), CASP7(4), CASP9(3), CYCS(2), EIF2S1(2), PRKCA(10), PTK2(12), PXN(6), STAT1(15), TLN1(23), TP53(74)	10367392	248	114	219	46	64	79	55	1	46	3	0.0011	0.48	1.00
84	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(6), GSTZ1(5), HGD(4)	842456	15	12	15	2	5	4	4	0	2	0	0.11	0.49	1.00
85	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(5), CCNA2(7), CCND1(15), CCNE1(6), CCNE2(8), CDK2(2), CDK4(3), CDKN1B(7), CDKN2A(2), E2F1(9), E2F2(3), E2F4(3), PRB1(2)	3299888	72	44	70	15	11	26	22	0	13	0	0.10	0.51	1.00
86	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	AKT1(4), AKT2(6), AKT3(11), BCL10(3), BLNK(4), BTK(12), CARD11(22), CD19(4), CD22(14), CD72(1), CD79A(1), CD79B(2), CHUK(8), CR2(24), FCGR2B(3), FOS(3), GSK3B(13), HRAS(1), IKBKB(13), IKBKG(4), INPP5D(9), JUN(1), KRAS(53), LILRB3(4), LYN(9), MALT1(4), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NRAS(9), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG2(29), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PTPN6(6), RAC1(1), RAC2(3), RASGRP3(13), SYK(4), VAV1(12), VAV2(7), VAV3(14)	27795344	787	208	614	159	183	284	167	7	130	16	1.84e-07	0.52	1.00
87	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(6), TPI1(2)	594208	8	7	8	1	0	3	1	0	4	0	0.28	0.56	1.00
88	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(19), BMPR1A(5), BMPR1B(6), BMPR2(12)	2288296	42	24	42	5	13	15	7	2	5	0	0.026	0.59	1.00
89	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(9), GOT2(3), TAT(7)	973896	19	13	19	2	7	6	5	1	0	0	0.088	0.59	1.00
90	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(4), AKT2(6), AKT3(11), BTK(12), CSF2(1), FCER1A(9), FCER1G(2), FYN(7), GAB2(10), GRB2(3), HRAS(1), IL3(2), IL4(1), IL5(2), INPP5D(9), KRAS(53), LCP2(5), LYN(9), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(10), MAPK9(5), MS4A2(3), NRAS(9), PDK1(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCG1(12), PLCG2(29), PRKCA(10), PRKCD(5), PRKCE(10), RAC1(1), RAC2(3), RAF1(8), SOS1(13), SOS2(17), SYK(4), VAV1(12), VAV2(7), VAV3(14)	26947680	781	210	602	155	186	270	173	9	126	17	3.33e-07	0.65	1.00
91	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(6), ACAT2(4), HMGCL(2), OXCT1(10)	1257360	22	15	21	3	8	8	3	0	3	0	0.11	0.65	1.00
92	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(9), GOT1(9), GOT2(3), TAT(7), TYR(12)	1743936	40	20	40	5	11	13	12	1	3	0	0.025	0.67	1.00
93	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(4), AKT2(6), AKT3(11), BAD(2), CASP9(3), CDC42(4), HRAS(1), KDR(26), KRAS(53), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPKAPK2(6), MAPKAPK3(5), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NOS3(11), NRAS(9), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCG1(12), PLCG2(29), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRKCA(10), PRKCG(8), PTGS2(9), PTK2(12), PXN(6), RAC1(1), RAC2(3), RAF1(8), SH2D2A(2), SHC2(5), SPHK1(2), SPHK2(2), SRC(3), VEGFA(2)	26941976	753	210	577	157	190	255	164	8	121	15	9.92e-07	0.69	1.00
94	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(6), LPL(16), NR3C1(18), PPARG(6), RETN(1), RXRA(3)	2006320	50	24	49	9	12	20	7	1	10	0	0.027	0.70	1.00
95	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT1(4), AKT2(6), AKT3(11), CASP8(21), CCL4(5), CCL5(2), CD14(2), CD40(4), CD80(5), CD86(5), CHUK(8), CXCL10(2), CXCL9(2), FADD(1), FOS(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IKBKB(13), IKBKE(4), IKBKG(4), IL12A(5), IL12B(2), IL1B(2), IL6(5), IL8(3), IRAK1(4), IRAK4(7), IRF3(2), IRF5(8), IRF7(1), JUN(1), LBP(3), LY96(4), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAP3K7(9), MAP3K8(10), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(10), MAPK9(5), MYD88(3), NFKB1(10), NFKB2(9), NFKBIA(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), RAC1(1), RELA(6), RIPK1(9), SPP1(2), STAT1(15), TBK1(7), TICAM1(7), TIRAP(2), TLR1(15), TLR2(16), TLR3(10), TLR4(17), TLR5(14), TLR6(14), TLR7(17), TLR8(19), TLR9(6), TOLLIP(1), TRAF3(5), TRAF6(7)	33193560	866	209	732	170	201	289	197	5	156	18	2.73e-08	0.72	1.00
96	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(11), APC(56), AXIN1(9), BTRC(14), CTNNB1(80), DLL1(7), DVL1(3), FZD1(3), GSK3B(13), NOTCH1(11), PSEN1(5), WNT1(1)	7827376	213	110	154	51	40	113	31	2	24	3	0.013	0.72	1.00
97	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(5), CCNE1(6), CDK2(2), CUL1(13), E2F1(9), RB1(26), SKP2(7), TFDP1(13)	3289968	81	39	79	18	28	21	17	0	12	3	0.042	0.74	1.00
98	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(6), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD4(6)	1218920	26	16	26	6	3	16	0	0	7	0	0.26	0.75	1.00
99	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(6), ALDOA(5), ALDOB(9), ALDOC(3), TPI1(2)	1432696	25	16	24	4	8	5	5	0	7	0	0.099	0.76	1.00
100	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(11), APC(56), ATF2(8), AXIN1(9), BMP10(9), BMP2(6), BMP4(10), BMP5(14), BMP7(12), BMPR1A(5), BMPR2(12), CHRD(11), CTNNB1(80), DVL1(3), FZD1(3), GATA4(3), GSK3B(13), MAP3K7(9), MEF2C(11), MYL2(2), NKX2-5(2), NOG(2), NPPA(2), NPPB(3), RFC1(21), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6), TGFBR3(15), WNT1(1)	13302472	360	130	295	73	92	170	54	3	38	3	0.00015	0.80	1.00
101	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6)	2091384	40	20	40	6	13	11	9	0	7	0	0.019	0.84	1.00
102	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	7	CCL5(2), CCR3(4), CSF2(1), IL3(2), IL5(2)	894536	11	10	11	1	2	4	2	0	3	0	0.12	0.86	1.00
103	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(5), ASPH(13), COPS5(5), CREB1(6), EDN1(4), EP300(32), EPO(2), HIF1A(16), JUN(1), LDHA(8), NOS3(11), P4HB(6), VHL(3)	6388976	112	46	111	16	32	32	26	2	20	0	0.00048	0.88	1.00
104	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(5), RAB11A(2), RAB1A(5), RAB27A(3), RAB3A(3), RAB4A(5), RAB5A(2), RAB6A(1), RAB9A(6)	1618696	32	17	30	9	13	8	5	0	6	0	0.23	0.89	1.00
105	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CCR3(4), CD4(6), IL1B(2), IL4(1), IL5(2), IL5RA(9), IL6(5)	1760056	29	21	27	8	3	13	3	0	10	0	0.31	0.89	1.00
106	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(8), SUCLA2(5)	821128	13	10	11	3	8	3	0	0	2	0	0.30	0.90	1.00
107	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(4), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), HSD3B7(5), PON1(12), PON2(6), PON3(5), RDH11(1), RDH12(5), RDH13(4), RDH14(2)	3329648	60	31	58	11	19	22	10	1	8	0	0.013	0.90	1.00
108	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(8), IDI1(3), SQLE(5)	1235040	17	12	17	2	4	8	4	0	1	0	0.16	0.90	1.00
109	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(8), IFNG(9), IL12A(5), IL12B(2), IL18(2), IL2(2)	1152952	28	20	27	8	9	9	6	1	3	0	0.51	0.91	1.00
110	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(6), FOS(3), FXYD2(3), JUN(1), KEAP1(8), MAFK(1), MAPK1(2), MAPK14(4), MAPK8(10), NFE2L2(15), PRKCA(10)	3371064	63	38	60	13	18	16	16	3	10	0	0.048	0.92	1.00
111	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(7), NDUFA4(1), NDUFA5(4), NDUFA8(5), NDUFB7(3), NDUFS1(13), NDUFS2(7), NDUFV1(3), NDUFV2(2)	2693776	46	28	45	9	18	16	6	1	4	1	0.11	0.93	1.00
112	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(7), COASY(11), DPYD(20), DPYS(6), ENPP1(12), ENPP3(18), PANK1(3), PANK2(7), PANK3(5), PANK4(5), PPCS(5), UPB1(10)	5099624	109	38	108	21	27	44	26	0	12	0	0.0090	0.95	1.00
113	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(4), AKT2(6), AKT3(11), BAD(2), BCR(6), BLNK(4), BTK(12), CD19(4), CD22(14), CR2(24), CSK(1), DAG1(6), FLOT2(2), GRB2(3), GSK3A(10), GSK3B(13), INPP5D(9), ITPR1(36), ITPR2(35), ITPR3(21), LYN(9), MAP4K1(11), MAPK1(2), MAPK3(3), NFATC1(10), NFATC2(13), NR0B2(2), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3R1(100), PLCG2(29), PPP1R13B(9), PPP3CA(4), PPP3CB(5), PPP3CC(6), PTPRC(17), RAF1(8), SHC1(7), SOS1(13), SOS2(17), SYK(4), VAV1(12)	27115328	690	203	559	152	170	228	155	8	112	17	0.000055	0.95	1.00
114	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(17), BAK1(3), BAX(3), BCL2L1(4), BID(2), BIRC2(10), BIRC3(5), CASP2(6), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CYCS(2), FADD(1), FAS(9), FASLG(7), GZMB(4), IKBKG(4), JUN(1), MAP2K4(9), MAP3K1(30), MAP3K14(6), MAPK10(9), MCL1(1), MDM2(4), MYC(8), NFKB1(10), NFKBIA(3), PARP1(9), PRF1(8), RELA(6), RIPK1(9), TNFRSF1A(4), TNFRSF1B(2), TNFSF10(1), TP53(74), TRAF1(5), TRAF2(3)	13633800	318	118	287	66	76	108	70	3	59	2	0.00066	0.96	1.00
115	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(2), FOSB(4), GRIA2(20), PPP1R1B(2)	1339448	28	17	27	8	8	7	6	0	6	1	0.34	0.96	1.00
116	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(5), BIRC3(5), CASP8(21), FADD(1), RIPK1(9), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3)	2746600	50	30	48	12	10	18	9	0	13	0	0.19	0.97	1.00
117	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	3	CD28(3), CD4(6)	647280	9	9	9	4	2	4	0	0	3	0	0.80	0.97	1.00
118	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP1(2), RANBP2(40), RANGAP1(3)	3179608	46	23	46	8	10	18	10	0	8	0	0.16	0.97	1.00
119	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(14), GABRA2(14), GABRA3(14), GABRA4(19), GABRA5(10), GABRA6(7), PRKCE(10), SOD1(2)	2937560	90	35	85	27	23	35	19	0	13	0	0.25	0.98	1.00
120	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(8), ACTN1(9), ACTR2(6), ACTR3(1), AKT1(4), AKT2(6), AKT3(11), ANGPTL2(6), ARHGEF6(26), ARHGEF7(15), BCAR1(8), BRAF(10), CAV1(2), CDC42(4), CDKN2A(2), CRK(2), CSE1L(14), DOCK1(24), EPHB2(12), FYN(7), GRB2(3), GRB7(5), ILK(5), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(20), ITGA9(16), ITGB3BP(3), MAP2K4(9), MAP2K7(4), MAP3K11(6), MAPK1(2), MAPK10(9), MAPK8(10), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(5), MRAS(1), MYLK(14), MYLK2(8), P4HB(6), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PIK3CA(172), PIK3CB(17), PKLR(7), PLCG1(12), PLCG2(29), PTEN(227), PTK2(12), RAF1(8), RALA(6), RHO(4), ROCK1(22), ROCK2(17), SHC1(7), SOS1(13), SOS2(17), SRC(3), TERF2IP(2), TLN1(23), TLN2(29), VASP(3), WAS(11), ZYX(11)	45704664	1111	215	897	234	264	338	230	39	208	32	2.61e-09	0.98	1.00
121	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(8), CDC25B(3), CDK7(7), CDKN1A(1), CHEK1(2), NEK1(19), WEE1(2)	2861920	42	22	40	7	14	17	5	0	6	0	0.15	0.98	1.00
122	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GBA3(9), GGT1(5), SHMT1(5), SHMT2(5)	1630600	25	17	25	5	9	9	3	0	4	0	0.100	0.98	1.00
123	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(54), CDC25A(8), CDC25B(3), CDC25C(5), CHEK1(2), MYT1(18), WEE1(2), YWHAH(3)	5201800	95	37	90	16	22	34	18	0	18	3	0.033	0.99	1.00
124	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(8), ABL2(22), AKT1(4), AKT2(6), AKT3(11), ARAF(12), AREG(1), BAD(2), BRAF(10), BTC(2), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CBL(12), CBLB(12), CBLC(5), CDKN1A(1), CDKN1B(7), CRK(2), CRKL(6), EGF(20), EGFR(12), ELK1(3), ERBB2(10), ERBB3(19), ERBB4(27), EREG(3), GAB1(8), GRB2(3), GSK3B(13), HBEGF(2), HRAS(1), JUN(1), KRAS(53), MAP2K1(2), MAP2K2(5), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(9), MAPK3(3), MAPK8(10), MAPK9(5), MYC(8), NCK1(4), NCK2(8), NRAS(9), NRG1(27), NRG2(4), NRG3(17), NRG4(1), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PLCG2(29), PRKCA(10), PRKCG(8), PTK2(12), RAF1(8), RPS6KB1(5), RPS6KB2(4), SHC1(7), SHC2(5), SHC3(15), SHC4(5), SOS1(13), SOS2(17), SRC(3), STAT5A(5), STAT5B(7)	38135208	998	215	817	206	253	350	213	7	156	19	3.08e-08	0.99	1.00
125	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(54), ATR(35), BRCA1(17), CCNB1(8), CDC25A(8), CDC25B(3), CDC25C(5), CDKN1A(1), CDKN2D(1), CHEK1(2), CHEK2(14), EP300(32), MDM2(4), MYT1(18), PRKDC(54), RPS6KA1(1), TP53(74), WEE1(2), YWHAH(3), YWHAQ(1)	16184728	337	117	304	64	73	103	83	4	71	3	0.0010	0.99	1.00
126	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(7), PGLYRP2(5)	642568	12	10	11	7	2	6	1	0	3	0	0.95	0.99	1.00
127	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(32), EP300(32), ESR1(11), MAPK1(2), MAPK3(3), PELP1(11), SRC(3)	5646712	94	47	89	21	26	24	25	1	17	1	0.064	0.99	1.00
128	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(6), CYP2C9(5)	748216	11	8	11	4	3	6	0	0	2	0	0.76	0.99	1.00
129	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(9), ENO1(6), GPI(7), HK1(11), PFKL(8), PGAM1(3), PGK1(7), PKLR(7), TPI1(2)	3458856	60	30	59	13	23	20	8	0	9	0	0.030	1.00	1.00
130	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(3), FOSL1(3), FOSL2(7), IFNAR1(7), IFNAR2(8), IFNB1(3), MAPK8(10), NFKB1(10), RELA(6), TNFRSF11A(4), TNFSF11(7), TRAF6(7)	3992552	75	31	73	14	19	26	22	0	8	0	0.029	1.00	1.00
131	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(32), EP300(32), LPL(16), NCOA1(19), NCOA2(15), PPARG(6), RXRA(3)	6913744	123	50	119	26	31	36	31	2	22	1	0.023	1.00	1.00
132	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(7), F13A1(8), F2(8), F2R(6), FGA(26), FGB(7), FGG(10), PLAT(6), PLAU(6), PLG(14), SERPINB2(9), SERPINE1(5)	5065400	112	38	108	25	24	51	25	1	11	0	0.036	1.00	1.00
133	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(10), CLOCK(9), CRY1(9), CRY2(3), CSNK1E(3), PER1(10)	3153816	44	25	43	9	13	16	7	1	7	0	0.15	1.00	1.00
134	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(2), IFNB1(3), IFNG(9), IL10(3), IL12A(5), IL12B(2), IL15(2), IL16(17), IL18(2), IL2(2), IL3(2), IL4(1), IL5(2), IL6(5), IL8(3), IL9(1), LTA(3)	3530032	64	27	63	18	16	27	12	1	8	0	0.19	1.00	1.00
135	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(3), LIPT1(5)	567672	8	7	8	4	2	3	2	0	1	0	0.92	1.00	1.00
136	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(3), BCKDK(6), CBS(11), CTH(6), MUT(10)	1829000	36	22	35	9	10	16	6	0	4	0	0.24	1.00	1.00
137	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(32), AKT1(4), ATM(54), BAX(3), CDKN1A(1), CPB2(7), CSNK1A1(4), CSNK1D(3), FHL2(2), HIF1A(16), IGFBP3(4), MAPK8(10), MDM2(4), NFKBIB(1), NQO1(3), TP53(74)	7384448	222	112	192	48	54	68	49	2	44	5	0.057	1.00	1.00
138	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(18), CD38(6), ENPP1(12), ENPP3(18), NADSYN1(6), NMNAT1(3), NMNAT2(3), NNMT(6), NNT(7), NT5C(1), NT5E(6), NT5M(3), QPRT(2)	5389784	91	31	89	19	23	37	28	0	3	0	0.018	1.00	1.00
139	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(6), GSS(5), IL8(3), NFKB1(10), NOX1(16), RELA(6), SOD1(2), XDH(14)	3618320	62	26	62	13	16	22	14	1	9	0	0.074	1.00	1.00
140	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(9), NFYB(2), NFYC(3), RB1(26), SP1(7), SP3(11)	2495624	58	27	55	11	17	14	14	0	10	3	0.13	1.00	1.00
141	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(7), BFAR(7), BRAF(10), CAMP(1), CREB1(6), CREB5(5), MAPK1(2), RAF1(8), SNX13(15), SRC(3), TERF2IP(2)	4298088	66	28	65	15	14	27	14	1	10	0	0.20	1.00	1.00
142	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(5), CCNB1(8), CCND1(15), CCND2(9), CCND3(4), CCNE1(6), CCNH(7), CDC25A(8), CDK2(2), CDK4(3), CDK6(3), CDK7(7), CDKN1A(1), CDKN1B(7), CDKN2A(2), CDKN2C(4), CDKN2D(1), E2F1(9), RB1(26), RBL1(14), TFDP1(13)	5806424	154	56	148	31	46	42	32	0	31	3	0.0072	1.00	1.00
143	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(6), DCN(11), FMOD(5), KERA(10), LUM(13)	1357304	45	20	41	12	15	18	7	0	5	0	0.22	1.00	1.00
144	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(9), GAD1(6), HDC(9), PNMT(2), TH(3), TPH1(9)	2226296	38	23	37	10	14	11	8	0	4	1	0.19	1.00	1.00
145	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(4), SRP19(3), SRP54(8), SRP68(5), SRP72(11), SRP9(1), SRPR(11)	2802896	44	21	44	9	10	22	6	0	6	0	0.24	1.00	1.00
146	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(6), ENO2(4), ENO3(5), FARS2(2), GOT1(9), GOT2(3), PAH(2), TAT(7), YARS(5)	3076192	43	21	43	10	15	14	10	1	3	0	0.18	1.00	1.00
147	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(8), CCNH(7), CDC25A(8), CDC25B(3), CDC25C(5), CDK7(7), SHH(4), XPO1(18)	3201184	60	25	57	12	24	15	14	0	7	0	0.093	1.00	1.00
148	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(4), GPLD1(13), PGAP1(17), PIGA(8), PIGB(11), PIGC(3), PIGF(2), PIGG(6), PIGH(5), PIGK(9), PIGL(1), PIGM(1), PIGN(13), PIGO(9), PIGP(3), PIGQ(5), PIGS(1), PIGT(7), PIGU(3), PIGV(7), PIGW(9), PIGX(2), PIGZ(5)	9326536	144	49	141	27	36	57	35	0	16	0	0.0015	1.00	1.00
149	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(4), ARG1(5), GLS(11), GLUD1(3), OAT(7), PRODH(12)	2147184	42	22	39	11	13	13	8	1	7	0	0.26	1.00	1.00
150	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(2), CALM2(4), CAMK1(2), CAMK1G(5), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CAMK4(5), CAMKK1(13), CAMKK2(7), CREB1(6), SYT1(4)	4388856	70	29	68	15	26	26	9	0	9	0	0.023	1.00	1.00
151	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(5), B3GNT2(1), B3GNT3(5), B3GNT4(4), B3GNT5(6), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), FUT1(4), FUT2(1), FUT3(8), FUT4(3), FUT5(1), FUT6(10), FUT7(2), FUT9(9), GCNT2(11), ST3GAL6(6), ST8SIA1(2)	5865944	100	38	99	21	43	35	12	1	9	0	0.0059	1.00	1.00
152	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(6), CD8A(2), CSF1(6), CSF2(1), CSF3(1), EPO(2), IL11(2), IL2(2), IL3(2), IL4(1), IL5(2), IL6(5), IL7(1), IL8(3), IL9(1)	2317808	37	29	37	12	10	16	4	1	6	0	0.40	1.00	1.00
153	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(5), FUT1(4), FUT2(1), FUT9(9), GCNT2(11), ST8SIA1(2)	2258784	32	18	32	8	16	11	5	0	0	0	0.11	1.00	1.00
154	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(4), ANKRD1(7), ATF3(3), CYR61(3), DUSP14(4), EIF4E(2), HBEGF(2), IFNG(9), IFRD1(6), IL18(2), IL1R1(5), MYOG(1), NR4A3(9), WDR1(10)	4020080	67	27	67	16	17	27	14	0	9	0	0.17	1.00	1.00
155	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(20), EGFR(12), ERBB3(19), NRG1(27)	3787952	78	35	75	17	23	30	15	0	10	0	0.11	1.00	1.00
156	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(56), AXIN1(9), CREBBP(32), CTNNB1(80), DVL1(3), EP300(32), FZD1(3), GSK3B(13), HDAC1(5), LDB1(5), LEF1(9), PITX2(12), TRRAP(42), WNT1(1)	12222432	302	125	238	76	62	134	53	4	44	5	0.020	1.00	1.00
157	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF2(1), CSF3(1), EPO(2), FLT3(16), IGF1(5), IL11(2), IL3(2), IL6(5), IL9(1), KITLG(3), TGFB1(2), TGFB2(5), TGFB3(9)	3204656	54	28	52	13	14	23	10	0	7	0	0.15	1.00	1.00
158	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(2), IFNAR1(7), IFNAR2(8), IFNB1(3), JAK1(20), STAT1(15), STAT2(8), TYK2(10)	4034216	73	30	71	20	21	21	21	0	10	0	0.25	1.00	1.00
159	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(17), ARHGAP5(21), ARHGDIB(3), CASP1(8), CASP10(8), CASP3(4), CASP8(21), CASP9(3), CYCS(2), GZMB(4), JUN(1), PRF1(8)	4762096	100	34	96	26	21	36	20	0	22	1	0.30	1.00	1.00
160	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(6), ACAT2(4), BDH1(3), BDH2(4), HMGCL(2), HMGCS1(6), HMGCS2(9), OXCT1(10), OXCT2(2)	2659800	46	25	45	11	14	19	8	1	4	0	0.21	1.00	1.00
161	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(8), GGPS1(2), IDI1(3), IDI2(1), SQLE(5)	1635312	20	13	20	5	5	10	4	0	1	0	0.47	1.00	1.00
162	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(5), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), HEMK1(3), LCMT1(2), LCMT2(9), METTL2B(4), METTL6(5), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), WBSCR22(5)	5481792	89	33	87	20	24	39	9	1	16	0	0.027	1.00	1.00
163	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(5), ASL(2), CPS1(22), GLS(11), GLUD1(3), GOT1(9)	2902840	52	22	51	12	11	22	8	1	8	2	0.24	1.00	1.00
164	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(6), NR0B2(2), NR1H3(4), NR1H4(7), RXRA(3)	1972344	25	17	25	7	9	6	4	1	5	0	0.32	1.00	1.00
165	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(20), JAK2(17), JAK3(10), PIAS1(7), PIAS3(9), PTPRU(19), REG1A(4), SOAT1(9)	5193120	97	37	96	24	29	32	17	1	15	3	0.11	1.00	1.00
166	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(9), IFNGR1(5), JAK1(20), JAK2(17), PTPRU(19), REG1A(4), STAT1(15)	4300320	91	37	90	24	32	26	15	0	15	3	0.20	1.00	1.00
167	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(3), ECHS1(3), HADH(1), HADHA(5), HADHB(4), HSD17B10(4), HSD17B4(13), MECR(6), PPT1(3), PPT2(1)	3056600	43	27	42	11	8	15	15	1	4	0	0.28	1.00	1.00
168	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(4), INPP1(3), INPP4A(21), INPP4B(16), INPP5A(5), INPPL1(19), ITPKA(1), ITPKB(12), MIOX(6), OCRL(19), PIK3C2A(23), PIK3C2B(10), PIK3C2G(16), PIK3CA(172), PIK3CB(17), PIK3CG(23), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(5), PLCG1(12), PLCG2(29)	16788112	456	162	351	102	131	147	119	5	53	1	0.0012	1.00	1.00
169	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD4(6), ICAM1(2), ITGAL(17), ITGB2(14), PTPRC(17), THY1(1)	4206576	75	36	74	25	22	31	9	1	12	0	0.34	1.00	1.00
170	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6(5), IL6R(7), JAK1(20), JAK2(17), JAK3(10), PIAS3(9), PTPRU(19), REG1A(4), SRC(3), STAT3(10)	5724336	106	41	105	28	28	35	21	1	18	3	0.13	1.00	1.00
171	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(14), F2(8), F2R(6), F3(6), F5(48), F7(2), FGA(26), FGB(7), FGG(10), PROC(5), PROS1(21), SERPINC1(10), TFPI(9)	6117912	172	42	164	37	37	86	32	1	15	1	0.020	1.00	1.00
172	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	9	CD3D(6), CD3E(2), CD3G(3), CD4(6), FYN(7), LCK(5), PTPRC(17), ZAP70(9)	3098512	55	25	55	16	12	24	8	0	11	0	0.35	1.00	1.00
173	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(6), CHRNA1(7), SNAP25(9), STX1A(1)	1209000	23	15	22	6	14	2	6	0	1	0	0.30	1.00	1.00
174	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(21), ANAPC10(2), ANAPC2(6), ANAPC4(5), ANAPC5(8), ANAPC7(5), BTRC(14), CDC16(12), CDC20(4), CDC23(7), CDC27(16), CUL1(13), CUL2(12), CUL3(14), FBXW11(5), FBXW7(46), FZR1(2), ITCH(10), RBX1(1), SKP2(7), SMURF1(12), SMURF2(7), TCEB1(2), TCEB2(2), UBA1(17), UBE2C(1), UBE2D2(4), UBE2D3(2), UBE2D4(2), UBE2E1(3), UBE2E2(3), UBE2E3(7), VHL(3), WWP1(19), WWP2(9)	15380216	303	94	281	60	97	91	67	2	45	1	0.00080	1.00	1.00
175	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(2), CALM2(4), CALML3(3), CALML6(4), CDS1(5), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKI(20), DGKQ(2), DGKZ(10), FN3K(5), IMPA1(4), IMPA2(6), INPP1(3), INPP4A(21), INPP4B(16), INPP5A(5), INPP5B(5), INPP5D(9), INPP5E(1), INPPL1(19), ITPK1(4), ITPKA(1), ITPKB(12), ITPR1(36), ITPR2(35), ITPR3(21), OCRL(19), PI4KA(18), PI4KB(9), PIK3C2A(23), PIK3C2B(10), PIK3C2G(16), PIK3C3(14), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIP4K2A(5), PIP4K2B(7), PIP4K2C(3), PIP5K1A(8), PIP5K1B(5), PIP5K1C(5), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(5), PLCD3(3), PLCD4(11), PLCE1(41), PLCG1(12), PLCG2(29), PLCZ1(14), PRKCA(10), PRKCG(8), PTEN(227), PTPMT1(2), SYNJ1(29), SYNJ2(11)	47609552	1267	223	1037	288	303	354	258	43	265	44	4.94e-06	1.00	1.00
176	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(3), ALAS1(8), ALAS2(11), CPO(3), FECH(7), GATA1(8), HBA1(1), HBA2(1), HBB(2), HMBS(8), UROD(3), UROS(3)	3165720	58	28	56	15	19	23	10	0	6	0	0.17	1.00	1.00
177	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(14), FOS(3), GRB2(3), HRAS(1), IL3(2), IL3RA(9), JAK2(17), MAP2K1(2), MAPK3(3), PTPN6(6), RAF1(8), SHC1(7), SOS1(13), STAT5A(5), STAT5B(7)	6686576	100	44	96	26	30	44	20	0	3	3	0.11	1.00	1.00
178	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(2), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), SHMT1(5)	5744424	107	44	105	29	29	41	13	0	24	0	0.18	1.00	1.00
179	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(2), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), SHMT1(5)	5744424	107	44	105	29	29	41	13	0	24	0	0.18	1.00	1.00
180	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(2), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), SHMT1(5)	5744424	107	44	105	29	29	41	13	0	24	0	0.18	1.00	1.00
181	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(5), APAF1(17), CASP3(4), CASP9(3), CYCS(2), DAXX(10), FAS(9), FASLG(7), HSPB2(1), MAPKAPK2(6), MAPKAPK3(5)	4048600	69	27	68	15	15	25	19	0	10	0	0.099	1.00	1.00
182	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), CD3D(6), CD3E(2), CD3G(3), GZMB(4), HLA-A(1), ICAM1(2), ITGAL(17), ITGB2(14), PRF1(8)	3180352	60	32	58	19	25	22	4	1	8	0	0.13	1.00	1.00
183	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD8A(2), ICAM1(2), ITGAL(17), ITGB2(14), PTPRC(17), THY1(1)	3940720	71	32	70	24	23	28	9	1	10	0	0.32	1.00	1.00
184	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	CD28(3), CD86(5), IFNG(9), IFNGR1(5), IFNGR2(4), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL18(2), IL18R1(9), IL2(2), IL2RA(4), IL4(1), IL4R(6)	4541872	80	33	79	26	26	26	15	1	12	0	0.36	1.00	1.00
185	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(21), ADRB2(7), CFTR(14), GNAS(24), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), SLC9A3R1(3)	4648016	96	36	92	26	38	28	15	1	13	1	0.15	1.00	1.00
186	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(7), IARS(8), LARS(19), LARS2(8), PDHA1(7), PDHA2(10), PDHB(3)	3740336	62	23	61	15	12	28	12	0	10	0	0.37	1.00	1.00
187	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSA(6), FARSB(7), GOT1(9), GOT2(3), PAH(2), TAT(7), YARS(5), YARS2(3)	3256240	44	24	44	11	16	14	11	1	2	0	0.24	1.00	1.00
188	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(10), CLOCK(9), CRY1(9), CRY2(3), CSNK1D(3), CSNK1E(3), NPAS2(14), NR1D1(3), PER1(10), PER2(13), PER3(15)	6270928	92	40	88	23	31	32	15	1	13	0	0.066	1.00	1.00
189	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5E(2), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), FDXR(3), SHMT1(5)	6053432	110	44	108	29	30	41	15	0	24	0	0.14	1.00	1.00
190	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(6), CD3D(6), CD3E(2), CD3G(3), CXCR3(5), ETV5(3), IFNG(9), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL18(2), IL18R1(9), JAK2(17), JUN(1), MAP2K6(10), MAPK14(4), MAPK8(10), STAT4(7), TYK2(10)	7059320	134	42	132	31	30	50	32	1	18	3	0.059	1.00	1.00
191	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(7), ACOX3(8), FADS2(2), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9)	3957088	62	33	59	18	25	20	6	2	9	0	0.18	1.00	1.00
192	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(9), ELK1(3), EPO(2), EPOR(4), FOS(3), GRB2(3), HRAS(1), JAK2(17), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(10), PLCG1(12), PTPN6(6), RAF1(8), SHC1(7), SOS1(13), STAT5A(5), STAT5B(7)	8172592	116	48	109	28	33	48	26	0	6	3	0.057	1.00	1.00
193	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(5), CTSD(4), ESR1(11), GREB1(20), HSPB2(1), MTA1(6), MTA3(6), PDZK1(5), TUBA8(7)	3994784	65	39	64	17	21	18	16	3	7	0	0.097	1.00	1.00
194	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(22), C5(18), C6(16), C7(20), C8A(9), C9(19)	4790616	104	33	99	27	21	45	23	0	13	2	0.21	1.00	1.00
195	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(9), IFNGR1(5), IFNGR2(4), JAK1(20), JAK2(17), STAT1(15)	3070488	70	32	69	22	19	22	14	0	12	3	0.57	1.00	1.00
196	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAD(2), BAX(3), CASP8(21), CYCS(2), FADD(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8(10), NFKB1(10), NSMAF(10), RAF1(8), RELA(6), RIPK1(9), SMPD1(11), TNFRSF1A(4), TRAF2(3)	7470008	146	52	141	32	32	52	27	0	34	1	0.034	1.00	1.00
197	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(22), AGT(8), AGTR1(4), AGTR2(11), CMA1(2), COL4A1(21), COL4A2(12), COL4A3(26), COL4A4(24), COL4A5(26), COL4A6(32), REN(4)	9806416	192	49	186	49	41	102	25	3	18	3	0.048	1.00	1.00
198	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2)	4965704	71	28	70	21	26	22	13	2	8	0	0.18	1.00	1.00
199	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(5), COQ5(5), COQ6(4), COQ7(3), NDUFA13(1), NDUFB11(3)	1574304	21	17	21	8	8	8	3	0	2	0	0.73	1.00	1.00
200	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(14), AGT(8), AGTR1(4), AGTR2(11), BDKRB2(8), KNG1(12), NOS3(11), REN(4)	3778776	72	29	69	20	31	29	6	1	5	0	0.069	1.00	1.00
201	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(17), BAK1(3), BAX(3), BCL2L1(4), BID(2), BIK(2), BIRC2(10), BIRC3(5), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CYCS(2), DFFB(4), DIABLO(2), ENDOG(1)	5041592	94	33	91	25	15	38	20	0	21	0	0.37	1.00	1.00
202	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(3), TGDS(4), UGDH(2), UGP2(6), UXS1(5)	1886536	21	15	20	9	7	7	5	0	2	0	0.86	1.00	1.00
203	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(6), IL1B(2), MST1(4), MST1R(12)	2305160	24	17	22	9	11	7	2	0	4	0	0.63	1.00	1.00
204	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(2), APEX1(2), CREBBP(32), DFFB(4), GZMA(6), GZMB(4), HMGB2(4), NME1(2), PRF1(8), SET(7)	4044384	71	34	67	20	23	23	11	0	13	1	0.21	1.00	1.00
205	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(5), CDKN1A(1), EPO(2), EPOR(4), GRIN1(4), HIF1A(16), JAK2(17), NFKB1(10), NFKBIA(3), RELA(6), SOD2(3)	4907424	71	30	71	20	17	27	15	1	8	3	0.27	1.00	1.00
206	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(7), CDO1(4), CSAD(7), GAD1(6), GAD2(12), GGT1(5)	2163800	41	23	41	13	9	13	12	2	5	0	0.43	1.00	1.00
207	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(7), HLCS(6), SPCS3(2)	1184448	15	10	15	9	2	4	8	0	1	0	0.96	1.00	1.00
208	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(5), ACP2(1), ACP5(5), ACPP(5), ACPT(5), ENPP1(12), ENPP3(18), FLAD1(5), RFK(1), TYR(12)	3687264	69	26	69	17	11	27	27	0	4	0	0.27	1.00	1.00
209	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), IL6(5), IL6R(7), IL6ST(11), JAK1(20), JAK2(17), JAK3(10), JUN(1), MAP2K1(2), MAPK3(3), PTPN11(8), RAF1(8), SHC1(7), SOS1(13), SRF(3), STAT3(10)	8892040	144	55	138	34	32	55	35	0	19	3	0.051	1.00	1.00
210	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(12), BID(2), BRAF(10), CASP3(4), CD244(6), CD247(5), CD48(2), CSF2(1), FAS(9), FASLG(7), FCER1G(2), FCGR3A(1), FCGR3B(2), FYN(7), GRB2(3), GZMB(4), HCST(1), HLA-A(1), HLA-B(4), HLA-C(2), HLA-E(1), HLA-G(2), HRAS(1), ICAM1(2), ICAM2(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IFNG(9), IFNGR1(5), IFNGR2(4), ITGAL(17), ITGB2(14), KIR2DL1(5), KIR2DL3(1), KIR2DL4(4), KIR3DL1(10), KIR3DL2(5), KLRC1(7), KLRC2(3), KLRC3(1), KLRD1(3), KLRK1(1), KRAS(53), LCK(5), LCP2(5), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MICA(3), MICB(2), NCR1(6), NCR2(3), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NRAS(9), PAK1(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PLCG2(29), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRF1(8), PRKCA(10), PRKCG(8), PTK2B(16), PTPN11(8), PTPN6(6), RAC1(1), RAC2(3), RAF1(8), SH2D1A(7), SH2D1B(4), SH3BP2(7), SHC1(7), SHC2(5), SHC3(15), SHC4(5), SOS1(13), SOS2(17), SYK(4), TNFRSF10A(2), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(6), TNFSF10(1), TYROBP(1), ULBP1(2), ULBP2(5), ULBP3(2), VAV1(12), VAV2(7), VAV3(14), ZAP70(9)	41711368	1027	212	844	241	254	375	227	8	146	17	6.86e-06	1.00	1.00
211	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(21), GNAS(24), GNB1(2), GNGT1(1), PRKACA(6), PRKAR1A(4)	2227784	58	29	56	15	29	14	8	0	7	0	0.27	1.00	1.00
212	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(5), ACP2(1), ACP5(5), ACP6(4), ACPP(5), ACPT(5), ENPP1(12), ENPP3(18), FLAD1(5), LHPP(2), MTMR1(16), MTMR2(5), MTMR6(10), PHPT1(1), RFK(1), TYR(12)	5676968	107	34	106	28	19	42	32	0	14	0	0.28	1.00	1.00
213	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(17), EGF(20), EGFR(12), HGS(8), RAB5A(2), TF(14), TFRC(4)	4793344	77	28	75	24	21	28	15	0	13	0	0.43	1.00	1.00
214	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), DCXR(1), GUSB(5), RPE(5), UCHL1(4), UCHL3(1), UGDH(2), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2B15(9), UGT2B4(11)	6578696	85	31	83	19	21	41	11	1	11	0	0.072	1.00	1.00
215	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(17), BAD(2), BAK1(3), BAX(3), BCL10(3), BCL2L1(4), BCL2L11(6), BID(2), CASP8AP2(3), CASP9(3), CES1(13)	4349920	59	27	58	13	10	23	18	0	8	0	0.22	1.00	1.00
216	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(5), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), ALDH1A3(8), ALDH3A1(7), ALDH3B2(7), AOC2(7), AOC3(10), AOX1(18), COMT(3), DBH(9), DCT(12), DDC(9), FAH(6), GOT1(9), GOT2(3), GSTZ1(5), HGD(4), HPD(7), MAOA(12), MAOB(7), PNMT(2), TAT(7), TH(3), TPO(15), TYR(12)	11803560	227	60	219	60	69	75	50	2	31	0	0.016	1.00	1.00
217	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(12), B3GALT2(8), B3GALT5(4), B3GNT5(6), FUT1(4), FUT2(1), FUT3(8), ST3GAL3(10), ST3GAL4(3)	2645168	56	24	54	16	20	17	10	1	8	0	0.23	1.00	1.00
218	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(6), CREM(8), FOS(3), JUN(1), MAPK3(3), OPRK1(10), POLR2A(21), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3)	4797560	79	35	77	23	30	22	15	1	10	1	0.13	1.00	1.00
219	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(8), APOBEC1(7), APOBEC2(4), APOBEC3A(1), APOBEC3B(6), APOBEC3C(4), APOBEC3F(6), APOBEC3G(3), APOBEC4(5)	2737424	44	21	44	12	15	18	9	1	1	0	0.35	1.00	1.00
220	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	AKT1(4), AKT2(6), AKT3(11), BCL10(3), CARD11(22), CBL(12), CBLB(12), CBLC(5), CD247(5), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD4(6), CD40LG(6), CD8A(2), CD8B(1), CDC42(4), CDK4(3), CHUK(8), CSF2(1), CTLA4(2), FOS(3), FYN(7), GRB2(3), HRAS(1), ICOS(3), IFNG(9), IKBKB(13), IKBKG(4), IL10(3), IL2(2), IL4(1), IL5(2), ITK(7), JUN(1), KRAS(53), LCK(5), LCP2(5), MALT1(4), MAP3K14(6), MAP3K8(10), NCK1(4), NCK2(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NRAS(9), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PDCD1(3), PDK1(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRKCQ(9), PTPN6(6), PTPRC(17), RASGRP1(8), RHOA(3), SOS1(13), SOS2(17), TEC(8), VAV1(12), VAV2(7), VAV3(14), ZAP70(9)	37447008	922	211	744	212	225	316	201	11	152	17	0.00011	1.00	1.00
221	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(7), IFNB1(3), JAK1(20), PTPRU(19), REG1A(4), STAT1(15), STAT2(8), TYK2(10)	4649256	86	34	85	24	34	23	19	0	10	0	0.17	1.00	1.00
222	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(21), CREM(8), FHL5(7), FSHR(17), GNAS(24), XPO1(18)	3342544	95	30	89	22	39	29	17	0	10	0	0.19	1.00	1.00
223	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(8), DUSP1(2), IKBKAP(13), IKBKB(13), IKBKG(4), MAP3K1(30), MAP3K14(6), NFKB1(10), NFKBIA(3), RELA(6), TNFAIP3(3), TRAF3(5), TRAF6(7)	6955408	110	40	109	25	25	42	20	1	20	2	0.10	1.00	1.00
224	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1(2), CAMK1G(5), HDAC9(16), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), YWHAH(3)	3093304	48	19	46	15	18	12	11	0	7	0	0.36	1.00	1.00
225	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(7), BCAT2(3), COASY(11), DPYD(20), DPYS(6), ENPP1(12), ENPP3(18), ILVBL(8), PANK1(3), PANK2(7), PANK3(5), PANK4(5), PPCDC(1), PPCS(5), UPB1(10), VNN1(9)	6408320	130	43	126	32	39	48	30	0	13	0	0.042	1.00	1.00
226	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(3), TGDS(4), UGDH(2), UXS1(5)	1497920	15	12	15	9	4	6	4	0	1	0	0.96	1.00	1.00
227	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(17), HSD17B1(4), HSD17B2(2), HSD17B3(6), HSD17B4(13), HSD17B7(5), HSD3B1(3), HSD3B2(6)	3024608	59	30	56	21	12	29	6	0	12	0	0.63	1.00	1.00
228	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(4), AKT2(6), AKT3(11), BCL2L1(4), CBL(12), CBLB(12), CBLC(5), CCND1(15), CCND2(9), CCND3(4), CISH(2), CLCF1(1), CNTF(3), CNTFR(2), CREBBP(32), CRLF2(5), CSF2(1), CSF2RA(12), CSF2RB(14), CSF3(1), CSF3R(8), EP300(32), EPO(2), EPOR(4), GH1(3), GH2(3), GHR(8), GRB2(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IFNG(9), IFNGR1(5), IFNGR2(4), IFNK(2), IFNW1(3), IL10(3), IL10RA(4), IL10RB(6), IL11(2), IL11RA(5), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL13RA1(13), IL13RA2(7), IL15(2), IL19(2), IL2(2), IL20(9), IL20RA(3), IL21(3), IL21R(7), IL22RA1(4), IL22RA2(1), IL23A(4), IL23R(5), IL24(7), IL26(3), IL28A(3), IL28B(2), IL28RA(9), IL29(2), IL2RA(4), IL2RB(3), IL2RG(13), IL3(2), IL3RA(9), IL4(1), IL4R(6), IL5(2), IL5RA(9), IL6(5), IL6R(7), IL6ST(11), IL7(1), IL7R(12), IL9(1), IL9R(8), IRF9(4), JAK1(20), JAK2(17), JAK3(10), LEP(2), LEPR(12), LIF(3), LIFR(27), MPL(7), MYC(8), OSM(2), OSMR(13), PIAS1(7), PIAS2(15), PIAS3(9), PIAS4(5), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIM1(3), PRL(6), PRLR(5), PTPN11(8), PTPN6(6), SOCS2(6), SOCS4(5), SOCS5(12), SOCS7(5), SOS1(13), SOS2(17), SPRED1(3), SPRED2(8), SPRY1(3), SPRY2(5), SPRY3(6), SPRY4(2), STAM(7), STAM2(5), STAT1(15), STAT2(8), STAT3(10), STAT4(7), STAT5A(5), STAT5B(7), STAT6(10), TPO(15), TSLP(2), TYK2(10)	54187504	1251	220	1109	281	291	441	289	11	195	24	1.48e-07	1.00	1.00
229	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(12), CNR2(6), DNMT1(14), MTNR1A(5), MTNR1B(4), PTAFR(4), PTGDR(9), PTGER2(3), PTGER4(12), PTGFR(13), PTGIR(3)	3977424	85	41	82	29	32	33	16	0	4	0	0.20	1.00	1.00
230	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2)	2952192	50	24	49	18	17	18	8	2	5	0	0.42	1.00	1.00
231	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2)	2952192	50	24	49	18	17	18	8	2	5	0	0.42	1.00	1.00
232	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(13), IL13RA2(7), IL4R(6), JAK1(20), JAK2(17), TYK2(10)	3914680	73	32	73	23	15	24	19	1	11	3	0.51	1.00	1.00
233	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(13), IL13RA2(7), IL4R(6), JAK1(20), JAK2(17), TYK2(10)	3914680	73	32	73	23	15	24	19	1	11	3	0.51	1.00	1.00
234	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(21), COL4A2(12), COL4A3(26), COL4A4(24), COL4A5(26), COL4A6(32), P4HB(6), SLC23A1(8), SLC23A2(7), SLC2A1(2), SLC2A3(8)	9835680	172	49	167	50	42	85	22	3	17	3	0.11	1.00	1.00
235	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(9), PARK2(6), SNCA(3), SNCAIP(12), UBE2E2(3), UBE2F(3), UBE2G1(2), UBE2L3(2), UBE2L6(3)	2357736	43	21	43	14	10	19	9	0	4	1	0.48	1.00	1.00
236	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(8), ACTB(3), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(2), CDC42(4), CDH1(14), CLDN1(3), CTNNB1(80), CTTN(4), EZR(4), FYN(7), HCLS1(12), ITGB1(8), KRT18(1), LY96(4), NCK1(4), NCK2(8), NCL(7), OCLN(2), PRKCA(10), RHOA(3), ROCK1(22), ROCK2(17), TLR4(17), TLR5(14), TUBA1A(9), TUBA1B(3), TUBA1C(5), TUBA3C(5), TUBA3D(4), TUBA3E(11), TUBA4A(11), TUBA8(7), TUBAL3(6), TUBB1(5), TUBB2A(2), TUBB2B(2), TUBB3(6), TUBB6(5), TUBB8(4), WAS(11), WASL(9), YWHAQ(1), YWHAZ(1)	19244552	380	127	322	100	97	171	68	4	38	2	0.0052	1.00	1.00
237	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(8), ACTB(3), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(2), CDC42(4), CDH1(14), CLDN1(3), CTNNB1(80), CTTN(4), EZR(4), FYN(7), HCLS1(12), ITGB1(8), KRT18(1), LY96(4), NCK1(4), NCK2(8), NCL(7), OCLN(2), PRKCA(10), RHOA(3), ROCK1(22), ROCK2(17), TLR4(17), TLR5(14), TUBA1A(9), TUBA1B(3), TUBA1C(5), TUBA3C(5), TUBA3D(4), TUBA3E(11), TUBA4A(11), TUBA8(7), TUBAL3(6), TUBB1(5), TUBB2A(2), TUBB2B(2), TUBB3(6), TUBB6(5), TUBB8(4), WAS(11), WASL(9), YWHAQ(1), YWHAZ(1)	19244552	380	127	322	100	97	171	68	4	38	2	0.0052	1.00	1.00
238	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(7), BCAT2(3), IARS(8), IARS2(20), ILVBL(8), LARS(19), LARS2(8), PDHA1(7), PDHA2(10), PDHB(3), VARS(6), VARS2(1)	5825272	100	33	97	26	32	36	18	0	14	0	0.25	1.00	1.00
239	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(5), ACTR2(6), ACTR3(1), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(4), RAC1(1), WASF1(3), WASL(9)	3077184	43	22	43	13	16	17	2	0	8	0	0.39	1.00	1.00
240	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ESCO1(16), ESCO2(8), NAT6(1), PNPLA3(7), SH3GLB1(7)	6039048	55	26	55	12	16	25	7	0	7	0	0.13	1.00	1.00
241	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(3), ST3GAL1(2), ST3GAL2(6), ST3GAL4(3), ST3GAL5(5), ST6GALNAC2(4), ST6GALNAC4(4), ST8SIA1(2)	2112960	29	21	28	10	13	11	4	0	1	0	0.39	1.00	1.00
242	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), GOT1(9), GOT2(3), GPT(2), GPT2(5), MDH1(4), MDH2(4), ME1(12), ME2(8), ME3(9), PGK1(7), PKLR(7), PKM2(5), RPE(5), RPIA(9), TKT(6), TPI1(2)	6687320	117	46	114	30	38	46	19	2	12	0	0.046	1.00	1.00
243	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(12), EIF2AK4(7), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), EIF5(3), GSK3B(13), PPP1CA(3)	4213520	60	28	57	14	18	20	6	3	13	0	0.28	1.00	1.00
244	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(8), CREBBP(32), EP300(32), FADD(1), HDAC3(12), IKBKB(13), IKBKG(4), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(9), TNFRSF1A(4), TNFRSF1B(2), TRAF6(7)	8122744	143	51	137	33	40	43	29	1	28	2	0.036	1.00	1.00
245	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(11), CYP2E1(2), NR1I3(6), PTGS1(6), PTGS2(9)	1964656	34	19	33	10	12	11	7	1	3	0	0.43	1.00	1.00
246	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(4), CD36(8), FOS(3), FYN(7), JUN(1), MAPK14(4), THBS1(11)	2681872	38	21	38	13	12	13	8	0	5	0	0.54	1.00	1.00
247	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(4), GRB2(3), IL2RG(13), IL4(1), IL4R(6), IRS1(13), JAK1(20), JAK3(10), RPS6KB1(5), SHC1(7), STAT6(10)	5444840	92	41	92	29	27	33	17	1	14	0	0.38	1.00	1.00
248	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(6), ACAT2(4), ACOT11(5), ACYP1(2), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ECHS1(3), EHHADH(11), ESCO1(16), ESCO2(8), FN3K(5), GCDH(6), HADHA(5), NAT6(1), PNPLA3(7), SH3GLB1(7), YOD1(3)	9604792	105	42	105	29	25	47	21	0	12	0	0.26	1.00	1.00
249	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(8), ACADM(9), ACADS(4), ACADVL(9), ACSL1(14), ACSL3(7), ACSL4(21), CPT1A(9), CPT2(4), EHHADH(11), HADHA(5), PECR(6), SCP2(9), SLC25A20(4)	6242408	120	38	116	31	32	45	28	0	15	0	0.11	1.00	1.00
250	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	BRAF(10), CPEB1(9), EGFR(12), ERBB2(10), ERBB4(27), ETS1(6), ETS2(6), ETV6(6), ETV7(4), FMN2(28), GRB2(3), KRAS(53), MAP2K1(2), MAPK1(2), MAPK3(3), NOTCH1(11), NOTCH2(18), NOTCH3(29), PIWIL1(21), PIWIL2(14), PIWIL3(10), PIWIL4(14), RAF1(8), SOS1(13), SOS2(17), SPIRE1(9), SPIRE2(4)	18180632	349	109	296	82	87	162	63	5	31	1	0.0014	1.00	1.00
251	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(16), POLR2A(21), POLR2B(22), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(2), POLR2K(2), POLRMT(11)	4881136	88	40	87	25	33	28	13	0	13	1	0.26	1.00	1.00
252	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(5), CHPT1(1), HEMK1(3), LCMT1(2), LCMT2(9), METTL2B(4), METTL6(5), PCYT1A(4), PCYT1B(4), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), WBSCR22(5)	5158648	82	32	80	24	21	36	8	2	15	0	0.27	1.00	1.00
253	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(8), ACADM(9), ACADS(4), ACAT1(6), ECHS1(3), HADHA(5)	1997888	35	19	35	12	7	14	11	0	3	0	0.64	1.00	1.00
254	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(12), EGF(20), EGFR(12), GRB2(3), HRAS(1), MAP2K1(2), MAPK1(2), MAPK3(3), PTPRB(31), RAF1(8), RASA1(30), SHC1(7), SOS1(13), SPRY1(3), SPRY2(5), SPRY3(6), SPRY4(2), SRC(3)	9354808	163	61	156	37	41	59	38	0	24	1	0.039	1.00	1.00
255	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(5), ACAD9(8), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ESCO1(16), ESCO2(8), NAT6(1), PNPLA3(7), SH3GLB1(7)	9198816	108	34	108	24	33	41	17	0	16	1	0.038	1.00	1.00
256	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CD14(2), CHUK(8), ELK1(3), FOS(3), IKBKB(13), IKBKG(4), IRAK1(4), JUN(1), LY96(4), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP3K1(30), MAP3K14(6), MAP3K7(9), MAPK14(4), MAPK8(10), MYD88(3), NFKB1(10), NFKBIA(3), PPARA(1), RELA(6), TIRAP(2), TLR10(19), TLR2(16), TLR3(10), TLR4(17), TLR6(14), TLR7(17), TLR9(6), TOLLIP(1), TRAF6(7)	13750112	259	66	256	57	58	102	54	1	40	4	0.0032	1.00	1.00
257	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(21), COL4A2(12), COL4A3(26), COL4A4(24), COL4A5(26), COL4A6(32), F10(14), F11(15), F12(2), F2(8), F2R(6), F5(48), F8(45), F9(14), FGA(26), FGB(7), FGG(10), KLKB1(10), PROC(5), PROS1(21), SERPINC1(10), SERPING1(7)	16978328	389	69	371	94	87	184	67	3	44	4	0.0084	1.00	1.00
258	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), DCXR(1), GUSB(5), RPE(5), UGDH(2), UGP2(6), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2A1(11), UGT2A3(5), UGT2B10(18), UGT2B11(18), UGT2B15(9), UGT2B17(7), UGT2B28(21), UGT2B4(11), UGT2B7(5), XYLB(5)	10208176	176	40	167	33	36	84	32	1	23	0	0.0031	1.00	1.00
259	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(6), ADCY3(12), ADCY9(27), AK1(1), ARF1(3), ARF3(4), ARF4(3), ARF5(4), ARF6(3), ARL4D(1), ATP6V0A1(7), ATP6V0A2(12), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(11), ATP6V1A(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), ERO1L(6), GNAS(24), PDIA4(5), PLCG1(12), PLCG2(29), PRKCA(10), SEC61A1(5), SEC61A2(4), SEC61B(2), SEC61G(3), TRIM23(11)	13792272	274	65	266	66	94	90	48	3	37	2	0.0030	1.00	1.00
260	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(5), ANXA2(4), ANXA3(3), ANXA4(9), ANXA5(3), ANXA6(11), CYP11A1(9), EDN1(4), EDNRA(5), EDNRB(4), HPGD(6), HSD11B1(6), PLA2G4A(13), PRL(6), PTGDR(9), PTGDS(5), PTGER2(3), PTGER4(12), PTGFR(13), PTGIR(3), PTGIS(7), PTGS1(6), PTGS2(9), SCGB1A1(2), TBXAS1(7)	7600952	164	50	163	40	47	67	30	2	18	0	0.017	1.00	1.00
261	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(6), CSF1R(8), DDX20(4), E2F1(9), E2F4(3), ETS1(6), ETS2(6), ETV3(11), FOS(3), HDAC2(5), HDAC5(12), HRAS(1), JUN(1), NCOR2(23), RBL1(14), RBL2(19), SIN3A(29), SIN3B(13)	10307624	173	61	166	44	59	49	34	0	30	1	0.030	1.00	1.00
262	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(3), ARFGAP1(2), ARFGAP3(4), ARFGEF2(28), CLTB(6), COPA(19), GBF1(14), GPLD1(13), KDELR1(3), KDELR3(4)	6064592	96	40	94	29	37	29	21	0	8	1	0.29	1.00	1.00
263	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(54), CCNA1(5), CCNB1(8), CCND1(15), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNG2(2), CCNH(7), CDC25A(8), CDK2(2), CDK4(3), CDK7(7), CDKN1A(1), CDKN1B(7), CDKN2A(2), CDKN2C(4), CDKN2D(1), CREB3L1(3), CREB3L3(7), CREB3L4(6), E2F1(9), E2F2(3), E2F3(4), E2F4(3), E2F5(6), E2F6(1), GBA2(13), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), MDM2(4), MYC(8), MYT1(18), NACA(21), PCNA(3), POLA2(3), POLE(47), POLE2(4), PRIM1(3), RB1(26), RBL1(14), RPA1(6), RPA2(3), RPA3(3), TFDP1(13), TFDP2(6), TNXB(19), TP53(74), WEE1(2)	27303808	532	147	483	126	150	189	103	3	81	6	0.0012	1.00	1.00
264	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(17), BAD(2), BAK1(3), BAX(3), BCL2L1(4), BCL2L11(6), BID(2), BIRC2(10), BIRC3(5), BIRC5(4), BNIP3L(1), CASP1(8), CASP10(8), CASP2(6), CASP3(4), CASP4(5), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CHUK(8), CYCS(2), DFFB(4), FADD(1), FAS(9), FASLG(7), GZMB(4), HELLS(11), IKBKB(13), IKBKG(4), IRF1(1), IRF2(7), IRF3(2), IRF4(8), IRF5(8), IRF6(9), IRF7(1), JUN(1), LTA(3), MAP2K4(9), MAP3K1(30), MAPK10(9), MDM2(4), MYC(8), NFKB1(10), NFKBIA(3), NFKBIB(1), NFKBIE(6), PLEKHG5(6), PRF1(8), RELA(6), RIPK1(9), TNFRSF10B(5), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(5), TNFRSF25(3), TNFSF10(1), TP53(74), TP73(6), TRAF1(5), TRAF2(3), TRAF3(5)	20966664	448	130	415	108	112	167	77	3	86	3	0.0035	1.00	1.00
265	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(8), MAP3K14(6), MAPK14(4), MAPK8(10), NFKB1(10), RELA(6), TNFRSF13B(3), TNFRSF17(1), TNFSF13B(5), TRAF2(3), TRAF3(5), TRAF5(7), TRAF6(7)	5464432	75	37	74	21	20	25	15	1	14	0	0.29	1.00	1.00
266	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	16	PSMA1(4), PSMA2(4), PSMA3(5), PSMA4(2), PSMA5(2), PSMA6(1), PSMA7(2), PSMB1(2), PSMB10(4), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(2), PSMB8(2)	2964096	43	23	41	14	12	11	8	0	12	0	0.56	1.00	1.00
267	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(8), ALOX15(9), ALOX15B(6), ALOX5(10), ALOX5AP(3), DPEP1(3), GGT1(5), LTA4H(4), PLA2G6(9), PTGDS(5), PTGES(2), PTGIS(7), PTGS1(6), PTGS2(9), TBXAS1(7)	5873384	93	33	91	27	40	29	17	1	6	0	0.11	1.00	1.00
268	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), GOT1(9), GOT2(3), GPT(2), GPT2(5), MDH1(4), MDH2(4), ME1(12), ME3(9), PGK1(7), PGK2(6), PKLR(7), PKM2(5), RPE(5), RPIA(9), TKT(6), TKTL1(9), TKTL2(15), TPI1(2)	7469016	139	53	134	37	47	55	18	2	17	0	0.039	1.00	1.00
269	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(18), CAPN1(5), CAPNS1(2), CAPNS2(3), CDK5(2), CDK5R1(3), CSNK1A1(4), CSNK1D(3), GSK3B(13), MAPT(9), PPP2CA(6)	3537968	68	29	67	22	31	18	9	0	10	0	0.31	1.00	1.00
270	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(54), MAP2(31), PPP1CA(3), PPP2CA(6), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAR2A(4), PRKAR2B(3), PRKCE(10)	6770152	126	40	123	31	24	50	29	0	20	3	0.21	1.00	1.00
271	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(17), ACO2(7), CS(6), GRHPR(3), HAO1(3), HAO2(11), HYI(2), MDH1(4), MDH2(4), MTHFD1(6), MTHFD1L(15), MTHFD2(4)	4792352	82	35	80	26	37	22	18	0	5	0	0.25	1.00	1.00
272	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	68	B2M(3), CALR(3), CANX(5), CD4(6), CD74(1), CD8A(2), CD8B(1), CIITA(15), CREB1(6), CTSL1(5), CTSS(4), HLA-A(1), HLA-B(4), HLA-C(2), HLA-DOB(3), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRB5(2), HLA-E(1), HLA-F(3), HLA-G(2), HSP90AA1(7), HSP90AB1(21), HSPA5(6), IFI30(1), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), KIR2DL1(5), KIR2DL3(1), KIR2DL4(4), KIR2DS4(5), KIR3DL1(10), KIR3DL2(5), KIR3DL3(3), KLRC1(7), KLRC2(3), KLRC3(1), KLRC4(5), KLRD1(3), LGMN(7), LTA(3), NFYA(9), NFYB(2), NFYC(3), PDIA3(5), PSME1(1), PSME2(4), RFX5(9), RFXANK(4), RFXAP(2), TAP1(8), TAPBP(4)	14405080	256	64	247	66	62	121	41	0	31	1	0.024	1.00	1.00
273	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(5), TAX1BP3(1), UBE2A(3), UBE2B(3), UBE2C(1), UBE2D2(4), UBE2D3(2), UBE2E1(3), UBE2E3(7), UBE2G1(2), UBE2H(1), UBE2J1(1), UBE2L3(2), UBE2L6(3), UBE2N(4), UBE3A(16)	3923856	58	27	58	20	16	15	16	2	9	0	0.61	1.00	1.00
274	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), IL2(2), IL2RA(4), IL2RB(3), IL2RG(13), JAK1(20), JAK3(10), JUN(1), LCK(5), MAP2K1(2), MAPK3(3), MAPK8(10), RAF1(8), SHC1(7), SOS1(13), STAT5A(5), STAT5B(7), SYK(4)	8787384	136	55	130	35	35	56	26	2	17	0	0.059	1.00	1.00
275	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(5), CREB1(6), CREBBP(32), EP300(32), NCOA3(10), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RARA(2), RXRA(3)	7747768	117	51	112	32	30	37	24	3	21	2	0.14	1.00	1.00
276	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(22), C5(18), C6(16), C7(20), ICAM1(2), IL6(5), IL8(3), ITGA4(10), ITGAL(17), ITGB1(8), ITGB2(14), SELP(12), SELPLG(9), VCAM1(12)	9235272	168	51	161	46	43	72	25	1	25	2	0.055	1.00	1.00
277	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(17), ACO2(7), AFMID(6), CS(6), GRHPR(3), HAO1(3), HAO2(11), HYI(2), MDH1(4), MDH2(4), MTHFD1(6), MTHFD1L(15), MTHFD2(4)	5033160	88	39	86	28	40	24	18	0	6	0	0.22	1.00	1.00
278	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(4), FUT2(1), FUT3(8), FUT5(1), FUT6(10), ST3GAL3(10)	1863720	34	20	34	12	18	11	2	0	3	0	0.31	1.00	1.00
279	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(3), ACTG1(6), ACTN1(9), ACTN2(16), ACTN3(10), ACTN4(8), AKT1(4), AKT2(6), AKT3(11), ARHGAP5(21), BAD(2), BCAR1(8), BIRC2(10), BIRC3(5), BRAF(10), CAPN2(11), CAV1(2), CAV2(1), CCND1(15), CCND2(9), CCND3(4), CDC42(4), CHAD(3), COL11A1(37), COL11A2(10), COL1A1(12), COL1A2(24), COL2A1(15), COL3A1(18), COL4A1(21), COL4A2(12), COL4A4(24), COL4A6(32), COL5A1(29), COL5A2(21), COL5A3(19), COL6A1(5), COL6A2(14), COL6A3(45), COL6A6(27), COMP(6), CRK(2), CRKL(6), CTNNB1(80), DIAPH1(13), DOCK1(24), EGF(20), EGFR(12), ELK1(3), ERBB2(10), FARP2(15), FIGF(5), FLNA(39), FLNB(34), FLNC(36), FLT1(20), FN1(43), FYN(7), GRB2(3), GSK3B(13), HGF(14), HRAS(1), IBSP(7), IGF1(5), IGF1R(13), ILK(5), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(10), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(20), ITGA9(16), ITGAV(10), ITGB1(8), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), JUN(1), KDR(26), LAMA1(32), LAMA2(61), LAMA3(30), LAMA4(15), LAMA5(17), LAMB1(23), LAMB2(26), LAMB3(16), LAMB4(32), LAMC1(18), LAMC2(17), LAMC3(17), MAP2K1(2), MAPK1(2), MAPK10(9), MAPK3(3), MAPK8(10), MAPK9(5), MET(17), MYL2(2), MYL5(1), MYL7(3), MYL9(3), MYLK(14), MYLK2(8), MYLPF(2), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PARVA(4), PARVB(2), PARVG(8), PDGFA(3), PDGFB(2), PDGFC(3), PDGFD(8), PDGFRA(24), PDGFRB(12), PDPK1(3), PGF(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIP5K1C(5), PPP1CA(3), PPP1CB(9), PPP1CC(4), PPP1R12A(8), PRKCA(10), PRKCG(8), PTEN(227), PTK2(12), PXN(6), RAC1(1), RAC2(3), RAF1(8), RAP1A(4), RAP1B(2), RAPGEF1(11), RELN(48), RHOA(3), ROCK1(22), ROCK2(17), SHC1(7), SHC2(5), SHC3(15), SHC4(5), SOS1(13), SOS2(17), SPP1(2), SRC(3), THBS1(11), THBS2(20), THBS3(3), THBS4(12), TLN1(23), TLN2(29), TNC(26), TNN(19), TNR(15), TNXB(19), VASP(3), VAV1(12), VAV2(7), VAV3(14), VCL(11), VEGFA(2), VEGFB(2), VEGFC(6), VTN(3), VWF(25), ZYX(11)	138854456	2816	237	2492	766	739	1006	501	60	446	64	1.16e-07	1.00	1.00
280	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ABI2(4), ACTN1(9), ACTN2(16), ACTN3(10), ACTN4(8), APC(56), ARAF(12), ARHGEF1(12), ARHGEF12(29), ARHGEF4(9), ARHGEF6(26), ARHGEF7(15), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), ARPC5(1), BAIAP2(5), BCAR1(8), BDKRB1(3), BDKRB2(8), BRAF(10), CD14(2), CDC42(4), CFL1(1), CFL2(8), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), CRK(2), CRKL(6), CSK(1), CYFIP1(9), CYFIP2(20), DIAPH1(13), DIAPH2(31), DIAPH3(27), DOCK1(24), EGF(20), EGFR(12), EZR(4), F2(8), F2R(6), FGD1(15), FGD3(9), FGF10(2), FGF11(1), FGF12(5), FGF13(4), FGF14(4), FGF17(1), FGF18(1), FGF21(1), FGF23(3), FGF3(1), FGF5(9), FGF6(2), FGF7(5), FGF8(4), FGF9(1), FGFR1(10), FGFR2(34), FGFR3(6), FGFR4(16), FN1(43), GIT1(9), GNA12(8), GNA13(7), GNG12(1), GSN(5), HRAS(1), INS(3), IQGAP1(12), IQGAP2(24), IQGAP3(16), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(10), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(20), ITGA9(16), ITGAD(10), ITGAE(9), ITGAL(17), ITGAM(21), ITGAV(10), ITGAX(14), ITGB1(8), ITGB2(14), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), KRAS(53), LIMK1(8), LIMK2(15), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MOS(6), MRAS(1), MSN(18), MYH10(29), MYH14(23), MYH9(22), MYL2(2), MYL5(1), MYL7(3), MYL9(3), MYLK(14), MYLK2(8), MYLPF(2), NCKAP1(8), NCKAP1L(20), NRAS(9), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PDGFA(3), PDGFB(2), PDGFRA(24), PDGFRB(12), PFN1(1), PFN2(2), PFN4(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIP4K2A(5), PIP4K2B(7), PIP4K2C(3), PIP5K1A(8), PIP5K1B(5), PIP5K1C(5), PPP1CA(3), PPP1CB(9), PPP1CC(4), PPP1R12A(8), PPP1R12B(20), PTK2(12), PXN(6), RAC1(1), RAC2(3), RAF1(8), RDX(16), RHOA(3), ROCK1(22), ROCK2(17), RRAS(3), RRAS2(4), SCIN(6), SLC9A1(8), SOS1(13), SOS2(17), SSH1(17), SSH2(13), SSH3(4), TIAM1(27), TIAM2(14), VAV1(12), VAV2(7), VAV3(14), VCL(11), WAS(11), WASF1(3), WASF2(3), WASL(9)	105296832	2109	225	1877	596	579	761	404	27	307	31	0.00011	1.00	1.00
281	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(9), ACTN2(16), ACTN3(10), ACTN4(8), ARHGAP5(21), BCAR1(8), CD99(1), CDC42(4), CDH5(6), CLDN1(3), CLDN10(8), CLDN11(2), CLDN15(5), CLDN16(4), CLDN17(4), CLDN18(7), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CTNNA1(18), CTNNA2(16), CTNNA3(13), CTNNB1(80), CTNND1(27), CXCL12(6), CXCR4(1), CYBA(2), CYBB(9), ESAM(1), EZR(4), F11R(1), GNAI1(5), GNAI2(6), GNAI3(4), ICAM1(2), ITGA4(10), ITGAL(17), ITGAM(21), ITGB1(8), ITGB2(14), ITK(7), JAM2(9), JAM3(3), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MLLT4(21), MMP2(7), MMP9(12), MSN(18), MYL2(2), MYL5(1), MYL7(3), MYL9(3), MYLPF(2), NCF1(3), NCF2(8), NCF4(5), NOX1(16), NOX3(7), OCLN(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PLCG2(29), PRKCA(10), PRKCG(8), PTK2(12), PTK2B(16), PTPN11(8), PXN(6), RAC1(1), RAC2(3), RAP1A(4), RAP1B(2), RAPGEF3(10), RAPGEF4(15), RASSF5(3), RHOA(3), RHOH(1), ROCK1(22), ROCK2(17), SIPA1(1), THY1(1), TXK(6), VASP(3), VAV1(12), VAV2(7), VAV3(14), VCAM1(12), VCL(11)	46726176	1140	221	950	291	284	409	236	12	179	20	0.00023	1.00	1.00
282	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	127	ACACA(33), ACACB(29), AKT1(4), AKT2(6), AKT3(11), ARAF(12), BAD(2), BRAF(10), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CBL(12), CBLB(12), CBLC(5), CRK(2), CRKL(6), ELK1(3), EXOC7(4), FASN(8), FBP1(2), FBP2(1), FLOT2(2), FOXO1(12), G6PC(5), G6PC2(11), GCK(3), GRB2(3), GSK3B(13), GYS1(13), GYS2(16), HRAS(1), IKBKB(13), INPP5D(9), INS(3), INSR(18), IRS1(13), IRS4(21), KRAS(53), LIPE(13), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK10(9), MAPK3(3), MAPK8(10), MAPK9(5), MKNK1(3), MKNK2(3), NRAS(9), PCK1(9), PCK2(7), PDE3A(19), PDE3B(15), PDPK1(3), PFKL(8), PFKM(9), PFKP(8), PHKA1(20), PHKA2(21), PHKB(15), PHKG1(7), PHKG2(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PKLR(7), PKM2(5), PPARGC1A(9), PPP1CA(3), PPP1CB(9), PPP1CC(4), PPP1R3A(32), PPP1R3B(2), PPP1R3C(4), PRKAA1(8), PRKAA2(10), PRKAB1(6), PRKAB2(1), PRKACA(6), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAG2(4), PRKAG3(6), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCI(6), PRKCZ(3), PRKX(2), PTPN1(5), PTPRF(27), PYGB(11), PYGL(8), PYGM(10), RAF1(8), RAPGEF1(11), RHEB(3), RHOQ(1), RPS6(7), RPS6KB1(5), RPS6KB2(4), SH2B2(1), SHC1(7), SHC2(5), SHC3(15), SHC4(5), SLC2A4(9), SOCS2(6), SOCS4(5), SORBS1(18), SOS1(13), SOS2(17), SREBF1(2), TRIP10(10), TSC1(13), TSC2(15)	59805448	1340	221	1146	336	389	448	263	16	203	21	5.21e-07	1.00	1.00
283	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(56), AXIN1(9), AXIN2(9), BTRC(14), CACYBP(2), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CCND1(15), CCND2(9), CCND3(4), CER1(4), CHD8(34), CREBBP(32), CSNK1A1(4), CSNK1A1L(4), CSNK1E(3), CSNK2A1(9), CSNK2A2(4), CTBP1(1), CTBP2(5), CTNNB1(80), CUL1(13), CXXC4(1), DAAM1(18), DAAM2(10), DKK1(3), DKK2(3), DKK4(3), DVL1(3), DVL2(10), DVL3(9), EP300(32), FBXW11(5), FOSL1(3), FZD1(3), FZD10(9), FZD2(8), FZD3(9), FZD4(4), FZD5(2), FZD6(13), FZD7(4), FZD8(2), FZD9(6), GSK3B(13), JUN(1), LEF1(9), LRP5(14), LRP6(26), MAP3K7(9), MAPK10(9), MAPK8(10), MAPK9(5), MYC(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NKD1(3), NLK(5), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PORCN(12), PPARD(3), PPP2CA(6), PPP2CB(4), PPP2R1A(30), PPP2R1B(6), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRICKLE1(6), PRICKLE2(3), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKX(2), PSEN1(5), RAC1(1), RAC2(3), RBX1(1), RHOA(3), ROCK1(22), ROCK2(17), RUVBL1(3), SENP2(12), SFRP1(6), SFRP2(4), SFRP4(9), SFRP5(2), SIAH1(6), SMAD2(9), SMAD3(7), SMAD4(5), SOX17(7), TBL1X(8), TBL1XR1(15), TCF7(3), TCF7L1(4), TCF7L2(11), TP53(74), VANGL1(6), VANGL2(10), WIF1(5), WNT1(1), WNT10A(2), WNT10B(2), WNT11(6), WNT16(7), WNT2(3), WNT2B(8), WNT3(3), WNT3A(1), WNT4(1), WNT5A(7), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2), WNT8A(2), WNT8B(5), WNT9A(4), WNT9B(2)	58747728	1178	218	1056	317	385	413	219	10	143	8	0.000020	1.00	1.00
284	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTB(3), ACTG1(6), ACTN1(9), ACTN2(16), ACTN3(10), ACTN4(8), AKT1(4), AKT2(6), AKT3(11), AMOTL1(13), ASH1L(42), CASK(18), CDC42(4), CDK4(3), CGN(14), CLDN1(3), CLDN10(8), CLDN11(2), CLDN15(5), CLDN16(4), CLDN17(4), CLDN18(7), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CRB3(1), CSDA(4), CSNK2A1(9), CSNK2A2(4), CTNNA1(18), CTNNA2(16), CTNNA3(13), CTNNB1(80), CTTN(4), EPB41(11), EPB41L1(15), EPB41L2(14), EPB41L3(17), EXOC3(8), EXOC4(6), F11R(1), GNAI1(5), GNAI2(6), GNAI3(4), HCLS1(12), HRAS(1), IGSF5(6), INADL(20), JAM2(9), JAM3(3), KRAS(53), LLGL1(10), LLGL2(7), MAGI1(24), MAGI2(28), MAGI3(16), MLLT4(21), MPDZ(22), MPP5(10), MRAS(1), MYH1(45), MYH10(29), MYH11(33), MYH13(22), MYH14(23), MYH15(23), MYH2(43), MYH3(30), MYH4(30), MYH6(16), MYH7(35), MYH7B(16), MYH8(30), MYH9(22), MYL2(2), MYL5(1), MYL7(3), MYL9(3), MYLPF(2), NRAS(9), OCLN(2), PARD3(19), PARD6B(3), PARD6G(1), PPM1J(3), PPP2CA(6), PPP2CB(4), PPP2R1A(30), PPP2R1B(6), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), PPP2R3A(12), PPP2R3B(9), PPP2R4(5), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCI(6), PRKCQ(9), PRKCZ(3), PTEN(227), RAB13(3), RAB3B(2), RHOA(3), RRAS(3), RRAS2(4), SPTAN1(31), SRC(3), SYMPK(17), TJAP1(6), TJP1(24), TJP2(16), TJP3(7), VAPA(6), YES1(8), ZAK(15)	73240352	1673	216	1432	455	445	588	282	52	267	39	0.00060	1.00	1.00
285	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	246	ACVR1B(9), ACVR1C(6), AKT1(4), AKT2(6), AKT3(11), ARRB1(4), ARRB2(4), ATF2(8), ATF4(3), BDNF(7), BRAF(10), CACNA1A(20), CACNA1B(35), CACNA1C(38), CACNA1D(29), CACNA1E(59), CACNA1F(41), CACNA1G(24), CACNA1H(12), CACNA1I(8), CACNA1S(33), CACNA2D1(14), CACNA2D2(10), CACNA2D3(22), CACNA2D4(15), CACNB1(12), CACNB2(13), CACNB3(5), CACNB4(13), CACNG1(1), CACNG2(3), CACNG3(10), CACNG4(6), CACNG5(4), CACNG6(4), CACNG7(7), CACNG8(1), CASP3(4), CD14(2), CDC25B(3), CDC42(4), CHUK(8), CRK(2), CRKL(6), DAXX(10), DDIT3(2), DUSP1(2), DUSP10(5), DUSP14(4), DUSP16(11), DUSP3(2), DUSP5(4), DUSP6(2), DUSP7(3), DUSP8(1), DUSP9(1), ECSIT(5), EGF(20), EGFR(12), ELK1(3), ELK4(3), FAS(9), FASLG(7), FGF10(2), FGF11(1), FGF12(5), FGF13(4), FGF14(4), FGF17(1), FGF18(1), FGF21(1), FGF23(3), FGF3(1), FGF5(9), FGF6(2), FGF7(5), FGF8(4), FGF9(1), FGFR1(10), FGFR2(34), FGFR3(6), FGFR4(16), FLNA(39), FLNB(34), FLNC(36), FOS(3), GADD45G(1), GNA12(8), GNG12(1), GRB2(3), HRAS(1), IKBKB(13), IKBKG(4), IL1B(2), IL1R1(5), IL1R2(5), JUN(1), KRAS(53), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K5(3), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K10(7), MAP3K12(8), MAP3K13(13), MAP3K14(6), MAP3K2(12), MAP3K3(9), MAP3K4(21), MAP3K5(25), MAP3K6(7), MAP3K7(9), MAP3K8(10), MAP4K1(11), MAP4K2(7), MAP4K3(16), MAP4K4(11), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK7(14), MAPK8(10), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(5), MAPKAPK2(6), MAPKAPK3(5), MAPKAPK5(5), MAPT(9), MAX(12), MEF2C(11), MKNK1(3), MKNK2(3), MOS(6), MRAS(1), MYC(8), NF1(36), NFATC2(13), NFATC4(7), NFKB1(10), NFKB2(9), NLK(5), NR4A1(5), NRAS(9), NTF3(5), NTRK1(13), NTRK2(13), PAK1(3), PAK2(3), PDGFA(3), PDGFB(2), PDGFRA(24), PDGFRB(12), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PPM1A(6), PPM1B(4), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PPP5C(7), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKX(2), PTPN5(8), PTPN7(6), PTPRR(17), RAC1(1), RAC2(3), RAF1(8), RAP1A(4), RAP1B(2), RAPGEF2(30), RASA1(30), RASA2(11), RASGRF1(11), RASGRF2(18), RASGRP1(8), RASGRP2(4), RASGRP3(13), RASGRP4(6), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA4(2), RPS6KA5(11), RPS6KA6(19), RRAS(3), RRAS2(4), SOS1(13), SOS2(17), SRF(3), STK3(12), STK4(9), STMN1(4), TAOK1(12), TAOK2(9), TAOK3(5), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6), TNFRSF1A(4), TP53(74), TRAF2(3), TRAF6(7), ZAK(15)	110330984	2106	201	1971	645	661	763	373	29	265	15	0.00018	1.00	1.00
286	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(11), ACVR1B(9), ACVRL1(2), AKT1(4), AURKB(4), BMPR1A(5), BMPR2(12), BUB1(10), CDKL1(9), CDKL2(5), CDS1(5), CLK1(7), CLK2(9), CLK4(6), COL4A3BP(3), CSNK2A1(9), CSNK2A2(4), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKQ(2), DGKZ(10), IMPA1(4), INPP1(3), INPP4A(21), INPP4B(16), INPP5A(5), INPPL1(19), ITPKA(1), ITPKB(12), MAP3K10(7), MOS(6), NEK1(19), NEK3(7), OCRL(19), PIK3C2A(23), PIK3C2B(10), PIK3C2G(16), PIK3CA(172), PIK3CB(17), PIK3CG(23), PIM2(5), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(5), PLCG1(12), PLCG2(29), PLK3(8), PRKACA(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCQ(9), PRKCZ(3), PRKD1(8), PRKG1(11), RAF1(8), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA4(2), RPS6KB1(5), STK11(2), TGFBR1(5), VRK1(12)	43017088	880	184	761	257	257	293	212	10	106	2	0.065	1.00	1.00
287	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CREB1(6), CREB3L1(3), CREB3L2(7), CREB3L3(7), CREB3L4(6), CREBBP(32), CTNNB1(80), DCT(12), DVL1(3), DVL2(10), DVL3(9), EDN1(4), EDNRB(4), EP300(32), FZD1(3), FZD10(9), FZD2(8), FZD3(9), FZD4(4), FZD5(2), FZD6(13), FZD7(4), FZD8(2), FZD9(6), GNAI1(5), GNAI2(6), GNAI3(4), GNAO1(7), GNAQ(3), GNAS(24), GSK3B(13), HRAS(1), KIT(24), KITLG(3), KRAS(53), LEF1(9), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MC1R(3), MITF(6), NRAS(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), POMC(4), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKX(2), RAF1(8), TCF7(3), TCF7L1(4), TCF7L2(11), TYR(12), TYRP1(7), WNT1(1), WNT10A(2), WNT10B(2), WNT11(6), WNT16(7), WNT2(3), WNT2B(8), WNT3(3), WNT3A(1), WNT4(1), WNT5A(7), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2), WNT8A(2), WNT8B(5), WNT9A(4), WNT9B(2)	39864264	836	177	718	266	277	305	159	11	82	2	0.010	1.00	1.00
288	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ABL1(8), ANAPC1(21), ANAPC10(2), ANAPC2(6), ANAPC4(5), ANAPC5(8), ANAPC7(5), ATM(54), ATR(35), BUB1(10), BUB1B(6), BUB3(4), CCNA1(5), CCNA2(7), CCNB1(8), CCNB2(5), CCNB3(33), CCND1(15), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNH(7), CDC14A(6), CDC14B(6), CDC16(12), CDC20(4), CDC23(7), CDC25A(8), CDC25B(3), CDC25C(5), CDC27(16), CDC6(3), CDC7(11), CDK2(2), CDK4(3), CDK6(3), CDK7(7), CDKN1A(1), CDKN1B(7), CDKN2A(2), CDKN2C(4), CDKN2D(1), CHEK1(2), CHEK2(14), CREBBP(32), CUL1(13), DBF4(11), E2F1(9), E2F2(3), E2F3(4), EP300(32), ESPL1(11), FZR1(2), GADD45G(1), GSK3B(13), HDAC1(5), HDAC2(5), MAD1L1(12), MAD2L1(4), MAD2L2(2), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), MDM2(4), PCNA(3), PKMYT1(2), PLK1(4), PRKDC(54), PTTG1(2), PTTG2(1), RB1(26), RBL1(14), RBL2(19), RBX1(1), SKP2(7), SMAD2(9), SMAD3(7), SMAD4(5), SMC1A(19), SMC1B(21), TFDP1(13), TGFB1(2), TGFB2(5), TGFB3(9), TP53(74), WEE1(2), YWHAE(4), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1)	51295824	919	173	870	224	259	300	190	5	154	11	0.0011	1.00	1.00
289	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY7(9), ADCY8(22), ADCY9(27), ADORA2A(6), ADORA2B(1), ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRB1(1), ADRB2(7), ADRB3(3), AGTR1(4), ATP2A1(12), ATP2A2(8), ATP2A3(11), ATP2B1(15), ATP2B2(12), ATP2B3(17), ATP2B4(14), AVPR1A(7), AVPR1B(3), BDKRB1(3), BDKRB2(8), BST1(1), CACNA1A(20), CACNA1B(35), CACNA1C(38), CACNA1D(29), CACNA1E(59), CACNA1F(41), CACNA1G(24), CACNA1H(12), CACNA1I(8), CACNA1S(33), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CAMK4(5), CCKAR(9), CCKBR(3), CD38(6), CHRM1(6), CHRM2(10), CHRM3(8), CHRM5(9), CHRNA7(5), CYSLTR1(8), CYSLTR2(5), DRD1(7), EDNRA(5), EDNRB(4), EGFR(12), ERBB2(10), ERBB3(19), ERBB4(27), F2R(6), GNA11(2), GNA14(7), GNA15(2), GNAL(6), GNAQ(3), GNAS(24), GRIN1(4), GRIN2A(25), GRIN2C(6), GRIN2D(5), GRM1(29), GRM5(27), GRPR(4), HRH1(10), HRH2(4), HTR2A(11), HTR2B(2), HTR2C(17), HTR4(8), HTR5A(12), HTR6(4), HTR7(5), ITPKA(1), ITPKB(12), ITPR1(36), ITPR2(35), ITPR3(21), LHCGR(17), LTB4R2(4), MYLK(14), MYLK2(8), NOS1(18), NOS3(11), NTSR1(5), OXTR(4), P2RX1(5), P2RX2(3), P2RX3(8), P2RX4(1), P2RX5(5), P2RX7(1), PDE1A(15), PDE1B(7), PDE1C(12), PDGFRA(24), PDGFRB(12), PHKA1(20), PHKA2(21), PHKB(15), PHKG1(7), PHKG2(3), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(5), PLCD3(3), PLCD4(11), PLCE1(41), PLCG1(12), PLCG2(29), PLCZ1(14), PLN(2), PPID(3), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKX(2), PTAFR(4), PTGER3(7), PTGFR(13), PTK2B(16), RYR1(72), RYR2(110), RYR3(94), SLC25A4(2), SLC25A5(2), SLC25A6(5), SLC8A1(13), SLC8A2(6), SLC8A3(13), SPHK1(2), SPHK2(2), TACR1(7), TACR2(3), TACR3(9), TNNC1(2), TNNC2(3), TRHR(3), TRPC1(13), VDAC1(2), VDAC2(3), VDAC3(2)	103529088	1962	172	1911	760	679	716	346	15	196	10	0.59	1.00	1.00
290	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	237	ADCYAP1R1(5), ADORA1(3), ADORA2A(6), ADORA2B(1), ADORA3(5), ADRA1A(12), ADRA1B(6), ADRA2A(6), ADRA2B(7), ADRA2C(2), ADRB1(1), ADRB2(7), ADRB3(3), AGTR1(4), AGTR2(11), AVPR1A(7), AVPR1B(3), AVPR2(5), BDKRB1(3), BDKRB2(8), BRS3(17), C3AR1(9), C5AR1(3), CALCR(9), CALCRL(8), CCKAR(9), CCKBR(3), CGA(1), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), CNR1(12), CNR2(6), CRHR1(3), CRHR2(2), CTSG(3), CYSLTR1(8), CYSLTR2(5), DRD1(7), DRD2(8), DRD3(6), DRD5(11), EDNRA(5), EDNRB(4), F2(8), F2R(6), F2RL1(4), F2RL2(2), FPR1(2), FSHR(17), GABBR1(12), GABBR2(15), GABRA1(14), GABRA2(14), GABRA3(14), GABRA4(19), GABRA5(10), GABRA6(7), GABRB1(9), GABRB2(15), GABRB3(10), GABRD(6), GABRE(7), GABRG1(10), GABRG2(16), GABRG3(9), GABRP(5), GABRQ(11), GABRR1(3), GALR1(3), GALR3(2), GH1(3), GH2(3), GHR(8), GHRHR(2), GHSR(8), GIPR(5), GLP1R(5), GLP2R(11), GLRA1(8), GLRA2(8), GLRA3(9), GLRB(7), GNRHR(4), GPR156(7), GPR35(3), GPR50(8), GPR63(5), GPR83(3), GRIA1(13), GRIA2(20), GRIA3(22), GRIA4(19), GRID1(12), GRID2(16), GRIK1(17), GRIK2(12), GRIK3(16), GRIK4(7), GRIK5(18), GRIN1(4), GRIN2A(25), GRIN2B(25), GRIN2C(6), GRIN2D(5), GRIN3A(15), GRIN3B(4), GRM1(29), GRM2(9), GRM3(19), GRM4(12), GRM5(27), GRM6(15), GRM7(20), GRM8(19), GRPR(4), GZMA(6), HCRTR2(11), HRH1(10), HRH2(4), HRH3(2), HRH4(5), HTR1A(14), HTR1B(6), HTR1D(6), HTR1E(11), HTR1F(11), HTR2A(11), HTR2B(2), HTR2C(17), HTR4(8), HTR5A(12), HTR6(4), HTR7(5), KISS1R(1), LEP(2), LEPR(12), LHB(2), LHCGR(17), LTB4R(2), LTB4R2(4), MAS1(3), MC1R(3), MC2R(4), MC3R(5), MC4R(5), MC5R(14), MCHR1(8), MCHR2(3), MLNR(5), MTNR1A(5), MTNR1B(4), NMBR(4), NMUR1(4), NMUR2(8), NPBWR2(2), NPFFR1(3), NPFFR2(13), NPY1R(9), NPY2R(5), NPY5R(13), NR3C1(18), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(10), OPRL1(3), OPRM1(13), OXTR(4), P2RX1(5), P2RX2(3), P2RX3(8), P2RX4(1), P2RX5(5), P2RX7(1), P2RY1(3), P2RY10(8), P2RY11(9), P2RY13(2), P2RY14(6), P2RY2(3), P2RY4(5), P2RY6(4), P2RY8(7), PARD3(19), PPYR1(8), PRL(6), PRLHR(1), PRLR(5), PRSS1(4), PRSS3(2), PTAFR(4), PTGDR(9), PTGER2(3), PTGER3(7), PTGER4(12), PTGFR(13), PTGIR(3), PTH2R(12), RXFP1(22), RXFP2(14), SCTR(5), SSTR1(10), SSTR2(3), SSTR3(3), SSTR4(10), SSTR5(2), TAAR1(7), TAAR2(7), TAAR5(5), TAAR6(6), TAAR8(3), TAAR9(8), TACR1(7), TACR2(3), TACR3(9), THRA(6), THRB(4), TRHR(3), TRPV1(3), TSHB(3), TSHR(8), TSPO(2), UTS2R(1), VIPR1(3), VIPR2(4)	81176600	1752	163	1691	652	544	754	284	19	146	5	0.063	1.00	1.00
291	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(8), ABLIM1(7), ABLIM2(8), ABLIM3(8), ARHGEF12(29), CDC42(4), CDK5(2), CFL1(1), CFL2(8), CXCL12(6), CXCR4(1), DCC(34), DPYSL2(12), DPYSL5(4), EFNA1(1), EFNA2(1), EFNA3(1), EFNA4(3), EFNA5(3), EFNB1(6), EFNB2(2), EFNB3(1), EPHA1(11), EPHA2(5), EPHA3(18), EPHA4(19), EPHA5(25), EPHA6(21), EPHA7(9), EPHA8(13), EPHB1(26), EPHB2(12), EPHB3(6), EPHB4(4), EPHB6(11), FES(17), FYN(7), GNAI1(5), GNAI2(6), GNAI3(4), GSK3B(13), HRAS(1), ITGB1(8), KRAS(53), L1CAM(20), LIMK1(8), LIMK2(15), LRRC4C(13), MAPK1(2), MAPK3(3), MET(17), NCK1(4), NCK2(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NGEF(15), NRAS(9), NRP1(16), NTN1(3), NTN4(6), NTNG1(8), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PLXNA1(24), PLXNA2(25), PLXNA3(18), PLXNB1(14), PLXNB2(16), PLXNB3(23), PLXNC1(26), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PTK2(12), RAC1(1), RAC2(3), RASA1(30), RGS3(11), RHOA(3), RHOD(1), RND1(6), ROBO1(24), ROBO2(24), ROBO3(16), ROCK1(22), ROCK2(17), SEMA3A(8), SEMA3B(6), SEMA3C(13), SEMA3D(14), SEMA3E(9), SEMA3F(6), SEMA3G(5), SEMA4A(8), SEMA4B(4), SEMA4C(7), SEMA4D(6), SEMA4F(11), SEMA4G(4), SEMA5A(19), SEMA5B(8), SEMA6A(9), SEMA6B(3), SEMA6C(5), SEMA6D(26), SEMA7A(11), SLIT1(14), SLIT2(29), SLIT3(20), SRGAP1(17), SRGAP2(14), SRGAP3(11), UNC5A(9), UNC5B(8), UNC5C(10), UNC5D(15)	73733128	1349	163	1266	451	432	489	239	8	175	6	0.089	1.00	1.00
292	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(5), ACTB(3), ACTG1(6), ACTN1(9), ACTN2(16), ACTN3(10), ACTN4(8), ACVR1B(9), ACVR1C(6), BAIAP2(5), CDC42(4), CDH1(14), CREBBP(32), CSNK2A1(9), CSNK2A2(4), CTNNA1(18), CTNNA2(16), CTNNA3(13), CTNNB1(80), CTNND1(27), EGFR(12), EP300(32), ERBB2(10), FARP2(15), FER(14), FGFR1(10), FYN(7), IGF1R(13), INSR(18), IQGAP1(12), LEF1(9), LMO7(26), MAP3K7(9), MAPK1(2), MAPK3(3), MET(17), MLLT4(21), NLK(5), PARD3(19), PTPN1(5), PTPN6(6), PTPRB(31), PTPRF(27), PTPRJ(18), PTPRM(15), PVRL1(10), PVRL2(5), PVRL3(7), PVRL4(4), RAC1(1), RAC2(3), RHOA(3), SMAD2(9), SMAD3(7), SMAD4(5), SNAI1(2), SNAI2(5), SORBS1(18), SRC(3), SSX2IP(11), TCF7(3), TCF7L1(4), TCF7L2(11), TGFBR1(5), TGFBR2(6), TJP1(24), VCL(11), WAS(11), WASF1(3), WASF2(3), WASF3(8), WASL(9), YES1(8)	45105000	849	162	772	222	254	303	169	10	106	7	0.00024	1.00	1.00
293	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(8), ATM(54), BUB1(10), BUB1B(6), BUB3(4), CCNA1(5), CCNA2(7), CCNB1(8), CCNB2(5), CCNB3(33), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNH(7), CDAN1(9), CDC14A(6), CDC14B(6), CDC20(4), CDC25A(8), CDC25B(3), CDC25C(5), CDC6(3), CDC7(11), CDH1(14), CDK2(2), CDK4(3), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(14), DTX4(4), E2F1(9), E2F2(3), E2F3(4), E2F4(3), E2F5(6), E2F6(1), EP300(32), ESPL1(11), GSK3B(13), HDAC1(5), HDAC2(5), HDAC3(12), HDAC4(14), HDAC5(12), HDAC6(25), HDAC8(2), MAD1L1(12), MAD2L1(4), MAD2L2(2), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), MDM2(4), MPEG1(9), MPL(7), PCNA(3), PLK1(4), PRKDC(54), PTPRA(10), PTTG1(2), PTTG2(1), RB1(26), RBL1(14), SKP2(7), SMAD4(5), TBC1D8(15), TFDP1(13), TGFB1(2), TP53(74), WEE1(2)	41835616	745	158	703	199	224	243	142	5	122	9	0.014	1.00	1.00
294	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRB1(1), ADRB2(7), ADRB3(3), ANXA6(11), ARRB1(4), ARRB2(4), ATP1A4(24), ATP1B1(6), ATP1B2(5), ATP1B3(3), ATP2A2(8), ATP2A3(11), ATP2B1(15), ATP2B2(12), ATP2B3(17), CACNA1A(20), CACNA1B(35), CACNA1C(38), CACNA1D(29), CACNA1E(59), CACNA1S(33), CACNB1(12), CACNB3(5), CALM1(2), CALM2(4), CALR(3), CAMK1(2), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CAMK4(5), CASQ1(8), CASQ2(9), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), FXYD2(3), GJA1(5), GJA4(1), GJA5(6), GJB1(3), GJB2(3), GJB3(4), GJB4(6), GJB5(2), GJB6(3), GNA11(2), GNAI2(6), GNAI3(4), GNAO1(7), GNAQ(3), GNAZ(4), GNB1(2), GNB2(7), GNB3(2), GNB4(4), GNB5(3), GNG12(1), GNG13(2), GNG2(2), GNG3(2), GNG4(5), GNG7(1), GNGT1(1), GRK4(10), GRK5(10), GRK6(2), ITPR1(36), ITPR2(35), ITPR3(21), KCNB1(13), KCNJ3(9), KCNJ5(7), MIB1(9), MYCBP(2), NME7(4), PEA15(2), PKIA(1), PLCB3(11), PLN(2), PRKACA(6), PRKACB(3), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCQ(9), PRKCZ(3), PRKD1(8), RGS1(6), RGS10(2), RGS11(1), RGS14(4), RGS16(5), RGS17(4), RGS18(3), RGS19(3), RGS2(3), RGS20(2), RGS3(11), RGS4(8), RGS5(4), RGS6(11), RGS7(9), RGS9(11), RYR1(72), RYR2(110), RYR3(94), SLC8A1(13), SLC8A3(13), USP5(13), YWHAH(3), YWHAQ(1)	72428648	1390	155	1358	526	490	513	222	11	145	9	0.37	1.00	1.00
295	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(12), BRAF(10), CACNA1A(20), CRH(1), CRHR1(3), GNA11(2), GNA12(8), GNA13(7), GNAI1(5), GNAI2(6), GNAI3(4), GNAO1(7), GNAQ(3), GNAS(24), GNAZ(4), GRIA1(13), GRIA2(20), GRIA3(22), GRID2(16), GRM1(29), GRM5(27), GUCY1A2(10), GUCY1A3(11), GUCY1B3(8), GUCY2C(14), GUCY2D(7), GUCY2F(26), HRAS(1), IGF1(5), IGF1R(13), ITPR1(36), ITPR2(35), ITPR3(21), KRAS(53), LYN(9), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), NOS1(18), NOS3(11), NPR1(12), NPR2(11), NRAS(9), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PPP2CA(6), PPP2CB(4), PPP2R1A(30), PPP2R1B(6), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), PRKCA(10), PRKCG(8), PRKG1(11), PRKG2(11), RAF1(8), RYR1(72)	41854464	843	150	766	272	259	355	134	9	83	3	0.054	1.00	1.00
296	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(3), ACTG1(6), CHAD(3), COL11A1(37), COL11A2(10), COL17A1(20), COL1A1(12), COL1A2(24), COL2A1(15), COL3A1(18), COL4A1(21), COL4A2(12), COL4A4(24), COL4A6(32), COL5A1(29), COL5A2(21), COL5A3(19), COL6A1(5), COL6A2(14), COL6A3(45), COL6A6(27), COMP(6), DES(6), DSC1(18), DSC2(14), DSC3(20), DSG1(24), DSG2(15), DSG3(23), DSG4(16), FN1(43), GJA1(5), GJA10(10), GJA3(5), GJA4(1), GJA5(6), GJA8(6), GJA9(15), GJB1(3), GJB2(3), GJB3(4), GJB4(6), GJB5(2), GJB6(3), GJB7(8), GJC1(2), GJC2(2), GJC3(2), GJD2(8), GJD4(3), IBSP(7), INA(5), ITGA6(12), ITGB4(8), KRT1(8), KRT10(3), KRT12(8), KRT13(6), KRT14(9), KRT15(10), KRT16(8), KRT17(4), KRT18(1), KRT19(6), KRT2(7), KRT20(4), KRT23(11), KRT24(5), KRT25(7), KRT27(4), KRT28(4), KRT3(9), KRT31(8), KRT32(10), KRT33A(7), KRT33B(5), KRT34(8), KRT35(9), KRT36(7), KRT37(8), KRT38(8), KRT39(14), KRT4(11), KRT40(5), KRT5(6), KRT6A(5), KRT6B(9), KRT6C(8), KRT7(3), KRT71(5), KRT72(6), KRT73(7), KRT74(1), KRT75(4), KRT76(6), KRT77(7), KRT78(5), KRT79(5), KRT8(7), KRT81(4), KRT82(1), KRT83(3), KRT84(7), KRT85(6), KRT86(1), KRT9(8), LAMA1(32), LAMA2(61), LAMA3(30), LAMA4(15), LAMA5(17), LAMB1(23), LAMB2(26), LAMB3(16), LAMB4(32), LAMC1(18), LAMC2(17), LAMC3(17), LMNA(8), LMNB1(5), LMNB2(4), NES(28), RELN(48), SPP1(2), THBS1(11), THBS2(20), THBS3(3), THBS4(12), TNC(26), TNN(19), TNR(15), TNXB(19), VIM(8), VTN(3), VWF(25)	92229216	1596	148	1561	531	489	636	259	20	177	15	0.067	1.00	1.00
297	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ATF4(3), CACNA1C(38), CACNA1D(29), CACNA1F(41), CACNA1S(33), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CDC42(4), CGA(1), EGFR(12), ELK1(3), GNA11(2), GNAQ(3), GNAS(24), GNRH1(1), GNRH2(1), GNRHR(4), GRB2(3), HBEGF(2), HRAS(1), ITPR1(36), ITPR2(35), ITPR3(21), JUN(1), KRAS(53), LHB(2), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K2(12), MAP3K3(9), MAP3K4(21), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK7(14), MAPK8(10), MAPK9(5), MMP14(6), MMP2(7), NRAS(9), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLD1(14), PLD2(10), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCD(5), PRKX(2), PTK2B(16), RAF1(8), SOS1(13), SOS2(17), SRC(3)	48849552	931	142	861	285	324	332	151	13	104	7	0.0035	1.00	1.00
298	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	59	APC(56), AXIN1(9), CCND1(15), CCND2(9), CCND3(4), CSNK1E(3), CTNNB1(80), DVL1(3), DVL2(10), DVL3(9), FBXW2(4), FOSL1(3), FZD1(3), FZD10(9), FZD2(8), FZD3(9), FZD5(2), FZD6(13), FZD7(4), FZD8(2), FZD9(6), GSK3B(13), JUN(1), LDLR(6), MAPK10(9), MAPK9(5), MYC(8), PAFAH1B1(2), PLAU(6), PPP2R5C(7), PPP2R5E(8), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCI(6), PRKCQ(9), PRKCZ(3), PRKD1(8), RAC1(1), RHOA(3), SFRP4(9), TCF7(3), WNT1(1), WNT10A(2), WNT10B(2), WNT11(6), WNT16(7), WNT2(3), WNT2B(8), WNT3(3), WNT4(1), WNT5A(7), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2)	21651888	460	141	390	147	138	176	87	4	51	4	0.091	1.00	1.00
299	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	84	AGRN(11), CD36(8), CD44(5), CD47(6), CHAD(3), COL11A1(37), COL11A2(10), COL1A1(12), COL1A2(24), COL2A1(15), COL3A1(18), COL4A1(21), COL4A2(12), COL4A4(24), COL4A6(32), COL5A1(29), COL5A2(21), COL5A3(19), COL6A1(5), COL6A2(14), COL6A3(45), COL6A6(27), DAG1(6), FN1(43), FNDC1(34), FNDC3A(7), FNDC4(3), FNDC5(2), GP5(3), GP6(5), HMMR(12), HSPG2(24), IBSP(7), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(10), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(20), ITGA9(16), ITGAV(10), ITGB1(8), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), LAMA1(32), LAMA2(61), LAMA3(30), LAMA4(15), LAMA5(17), LAMB1(23), LAMB2(26), LAMB3(16), LAMB4(32), LAMC1(18), LAMC2(17), LAMC3(17), RELN(48), SDC1(1), SDC2(1), SDC3(2), SDC4(4), SPP1(2), SV2A(14), SV2B(13), SV2C(17), THBS1(11), THBS2(20), THBS3(3), THBS4(12), TNC(26), TNN(19), TNR(15), TNXB(19), VTN(3), VWF(25)	83671976	1319	140	1290	457	394	528	211	16	155	15	0.30	1.00	1.00
300	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ACTA1(5), ACTA2(7), ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ADM(2), ARRB1(4), ARRB2(4), ATF1(6), ATF2(8), ATF3(3), ATF4(3), ATF5(6), ATP2A2(8), ATP2A3(11), CACNB3(5), CALCA(2), CALM1(2), CALM2(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CNN1(3), CNN2(1), CORIN(13), CRH(1), CRHR1(3), DGKZ(10), ETS2(6), FOS(3), GABPA(8), GABPB2(12), GBA2(13), GJA1(5), GNAQ(3), GNB1(2), GNB2(7), GNB3(2), GNB4(4), GNB5(3), GNG12(1), GNG13(2), GNG2(2), GNG3(2), GNG4(5), GNG7(1), GNGT1(1), GRK4(10), GRK5(10), GRK6(2), GSTO1(3), GUCA2B(1), GUCY1A3(11), IGFBP1(4), IGFBP2(5), IGFBP3(4), IGFBP4(3), IGFBP6(2), IL1B(2), IL6(5), ITPR1(36), ITPR2(35), ITPR3(21), JUN(1), MIB1(9), MYL2(2), MYLK2(8), NFKB1(10), NOS1(18), NOS3(11), OXTR(4), PDE4B(14), PDE4D(9), PKIA(1), PLCB3(11), PLCD1(5), PLCG1(12), PLCG2(29), PRKACA(6), PRKACB(3), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), PRKCD(5), PRKCE(10), PRKCH(10), PRKCQ(9), PRKCZ(3), PRKD1(8), RAMP1(1), RAMP3(2), RGS1(6), RGS10(2), RGS11(1), RGS14(4), RGS16(5), RGS17(4), RGS18(3), RGS19(3), RGS2(3), RGS20(2), RGS3(11), RGS4(8), RGS5(4), RGS6(11), RGS7(9), RGS9(11), RLN1(1), RYR1(72), RYR2(110), RYR3(94), SLC8A1(13), SP1(7), TNXB(19), USP5(13), YWHAH(3), YWHAQ(1)	64722296	1166	137	1134	437	387	438	203	7	124	7	0.56	1.00	1.00
301	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	ALG2(2), BAK1(3), BAX(3), BFAR(7), BTK(12), CAD(25), CASP10(8), CASP3(4), CASP8(21), CASP8AP2(3), CD7(3), CDK2AP1(1), CSNK1A1(4), DAXX(10), DEDD(2), DEDD2(2), DIABLO(2), EGFR(12), EPHB2(12), FADD(1), FAF1(10), FAIM2(3), IL8(3), MAP2K4(9), MAP2K7(4), MAP3K1(30), MAP3K5(25), MAPK1(2), MAPK10(9), MAPK8(10), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(5), MET(17), NFAT5(16), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NR0B2(2), PFN1(1), PFN2(2), PTPN13(30), RALBP1(6), RIPK1(9), ROCK1(22), SMPD1(11), TNFRSF6B(1), TP53(74), TPX2(12), TRAF2(3), TUFM(5)	27330592	502	137	467	126	135	183	84	2	93	5	0.0044	1.00	1.00
302	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1(11), ACVR1B(9), ACVR2A(7), ACVR2B(5), AMHR2(3), BMP2(6), BMP7(12), BMPR1A(5), BMPR1B(6), BMPR2(12), CCL1(1), CCL13(2), CCL14(1), CCL15(1), CCL16(1), CCL17(1), CCL18(1), CCL21(1), CCL23(3), CCL24(3), CCL25(1), CCL28(2), CCL4(5), CCL5(2), CCL7(4), CCL8(3), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR6(5), CCR7(6), CCR8(6), CCR9(4), CD27(4), CD40(4), CD40LG(6), CD70(2), CLCF1(1), CNTF(3), CNTFR(2), CRLF2(5), CSF1(6), CSF1R(8), CSF2(1), CSF2RA(12), CSF2RB(14), CSF3(1), CSF3R(8), CX3CL1(3), CX3CR1(6), CXCL1(3), CXCL10(2), CXCL12(6), CXCL13(2), CXCL16(2), CXCL2(2), CXCL3(1), CXCL5(3), CXCL9(2), CXCR3(5), CXCR4(1), CXCR6(1), EDA(5), EDA2R(6), EDAR(5), EGF(20), EGFR(12), EPO(2), EPOR(4), FAS(9), FASLG(7), FLT1(20), FLT3(16), FLT3LG(2), FLT4(9), GDF5(7), GH1(3), GH2(3), GHR(8), HGF(14), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IFNG(9), IFNGR1(5), IFNGR2(4), IFNK(2), IFNW1(3), IL10(3), IL10RA(4), IL10RB(6), IL11(2), IL11RA(5), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL13RA1(13), IL15(2), IL17RA(5), IL17RB(5), IL18(2), IL18R1(9), IL18RAP(15), IL19(2), IL1B(2), IL1R1(5), IL1R2(5), IL1RAP(8), IL2(2), IL20(9), IL20RA(3), IL21(3), IL21R(7), IL22RA1(4), IL22RA2(1), IL23A(4), IL23R(5), IL24(7), IL25(2), IL26(3), IL28A(3), IL28B(2), IL28RA(9), IL29(2), IL2RA(4), IL2RB(3), IL2RG(13), IL3(2), IL3RA(9), IL4(1), IL4R(6), IL5(2), IL5RA(9), IL6(5), IL6R(7), IL6ST(11), IL7(1), IL7R(12), IL8(3), IL9(1), IL9R(8), INHBA(8), INHBB(2), INHBC(3), INHBE(6), KDR(26), KIT(24), KITLG(3), LEP(2), LEPR(12), LIF(3), LIFR(27), LTA(3), LTBR(5), MET(17), MPL(7), NGFR(3), OSM(2), OSMR(13), PDGFB(2), PDGFC(3), PDGFRA(24), PDGFRB(12), PF4(1), PF4V1(1), PLEKHO2(6), PPBP(1), PRL(6), PRLR(5), RELT(2), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6), TNFRSF10A(2), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(6), TNFRSF11A(4), TNFRSF11B(13), TNFRSF13B(3), TNFRSF14(2), TNFRSF17(1), TNFRSF19(4), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(5), TNFRSF25(3), TNFRSF6B(1), TNFRSF8(8), TNFRSF9(2), TNFSF10(1), TNFSF11(7), TNFSF12(4), TNFSF13B(5), TNFSF14(2), TNFSF15(3), TNFSF18(4), TNFSF4(4), TNFSF8(1), TNFSF9(6), TPO(15), TSLP(2), VEGFA(2), VEGFB(2), VEGFC(6), XCL2(2), XCR1(3)	65843752	1177	135	1155	361	307	473	236	6	150	5	0.015	1.00	1.00
303	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), AKAP1(9), AKAP10(9), AKAP11(23), AKAP12(21), AKAP3(21), AKAP4(15), AKAP5(3), AKAP6(34), AKAP7(7), AKAP8(5), AKAP9(54), ARHGEF1(12), CALM1(2), CALM2(4), CHMP1B(1), GNA11(2), GNA12(8), GNA13(7), GNA14(7), GNA15(2), GNAI2(6), GNAI3(4), GNAL(6), GNAO1(7), GNAQ(3), GNAZ(4), GNB1(2), GNB2(7), GNB3(2), GNB5(3), GNG12(1), GNG13(2), GNG3(2), GNG4(5), GNG7(1), GNGT1(1), GNGT2(3), HRAS(1), IL18BP(1), ITPR1(36), KCNJ3(9), KRAS(53), NRAS(9), PALM2(7), PDE1A(15), PDE1B(7), PDE1C(12), PDE4A(10), PDE4B(14), PDE4C(2), PDE4D(9), PDE7A(1), PDE7B(7), PDE8A(7), PDE8B(19), PLCB3(11), PPP3CA(4), PPP3CC(6), PRKACA(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCI(6), PRKCQ(9), PRKCZ(3), PRKD1(8), PRKD3(11), RHOA(3), RRAS(3), SLC9A1(8), USP5(13)	43939648	836	134	773	301	263	293	173	6	97	4	0.52	1.00	1.00
304	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	125	ALCAM(7), CADM1(4), CADM3(10), CD2(4), CD22(14), CD226(6), CD274(1), CD276(2), CD28(3), CD34(1), CD4(6), CD40(4), CD40LG(6), CD58(2), CD6(6), CD80(5), CD86(5), CD8A(2), CD8B(1), CD99(1), CDH1(14), CDH15(8), CDH2(19), CDH3(6), CDH4(17), CDH5(6), CLDN1(3), CLDN10(8), CLDN11(2), CLDN15(5), CLDN16(4), CLDN17(4), CLDN18(7), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CNTN1(18), CNTN2(6), CNTNAP1(12), CNTNAP2(31), CTLA4(2), ESAM(1), F11R(1), GLG1(8), HLA-A(1), HLA-B(4), HLA-C(2), HLA-DOB(3), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRB5(2), HLA-E(1), HLA-F(3), HLA-G(2), ICAM1(2), ICAM2(3), ICAM3(3), ICOS(3), ICOSLG(2), ITGA4(10), ITGA6(12), ITGA8(20), ITGA9(16), ITGAL(17), ITGAM(21), ITGAV(10), ITGB1(8), ITGB2(14), ITGB7(4), ITGB8(9), JAM2(9), JAM3(3), L1CAM(20), MADCAM1(2), MAG(7), MPZ(3), MPZL1(3), NCAM1(9), NCAM2(33), NEGR1(7), NEO1(17), NFASC(33), NLGN1(9), NLGN2(7), NLGN3(25), NRCAM(14), NRXN1(36), NRXN2(17), NRXN3(29), OCLN(2), PDCD1(3), PDCD1LG2(1), PTPRC(17), PTPRF(27), PTPRM(15), PVR(3), PVRL1(10), PVRL2(5), PVRL3(7), SDC1(1), SDC2(1), SDC3(2), SDC4(4), SELE(5), SELL(5), SELP(12), SELPLG(9), SIGLEC1(12), SPN(1), VCAM1(12), VCAN(66)	53098288	968	132	939	324	300	374	164	5	116	9	0.037	1.00	1.00
305	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ADRB1(1), CSNK1D(3), DRD1(7), DRD2(8), EGF(20), EGFR(12), GJA1(5), GJD2(8), GNA11(2), GNAI1(5), GNAI2(6), GNAI3(4), GNAQ(3), GNAS(24), GRB2(3), GRM1(29), GRM5(27), GUCY1A2(10), GUCY1A3(11), GUCY1B3(8), GUCY2C(14), GUCY2D(7), GUCY2F(26), HRAS(1), HTR2A(11), HTR2B(2), HTR2C(17), ITPR1(36), ITPR2(35), ITPR3(21), KRAS(53), MAP2K1(2), MAP2K2(5), MAP2K5(3), MAP3K2(12), MAPK1(2), MAPK3(3), MAPK7(14), NPR1(12), NPR2(11), NRAS(9), PDGFA(3), PDGFB(2), PDGFC(3), PDGFD(8), PDGFRA(24), PDGFRB(12), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKG1(11), PRKG2(11), PRKX(2), RAF1(8), SOS1(13), SOS2(17), SRC(3), TJP1(24), TUBA1A(9), TUBA1B(3), TUBA1C(5), TUBA3C(5), TUBA3D(4), TUBA3E(11), TUBA4A(11), TUBA8(7), TUBAL3(6), TUBB1(5), TUBB2A(2), TUBB2B(2), TUBB3(6), TUBB6(5), TUBB8(4)	49386720	948	132	880	293	291	362	182	12	98	3	0.0080	1.00	1.00
306	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(21), ADCY8(22), ARAF(12), ATF4(3), BRAF(10), CACNA1C(38), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CAMK4(5), CREBBP(32), EP300(32), GNAQ(3), GRIA1(13), GRIA2(20), GRIN1(4), GRIN2A(25), GRIN2B(25), GRIN2C(6), GRIN2D(5), GRM1(29), GRM5(27), HRAS(1), ITPR1(36), ITPR2(35), ITPR3(21), KRAS(53), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), NRAS(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PPP1CA(3), PPP1CB(9), PPP1CC(4), PPP1R12A(8), PPP1R1A(4), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKX(2), RAF1(8), RAP1A(4), RAP1B(2), RAPGEF3(10), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA6(19)	38493568	739	132	674	244	225	280	144	7	80	3	0.10	1.00	1.00
307	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADA(2), ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ADK(2), ADSL(8), ADSS(6), ADSSL1(5), AK1(1), AK2(3), AK5(8), AK7(13), ALLC(8), AMPD1(23), AMPD2(6), AMPD3(7), ATIC(7), CANT1(1), DCK(5), ENPP1(12), ENPP3(18), ENTPD1(3), ENTPD3(5), ENTPD4(2), ENTPD5(2), ENTPD6(10), ENTPD8(5), FHIT(4), GART(9), GDA(4), GMPR(6), GMPR2(3), GMPS(14), GUCY1A2(10), GUCY1A3(11), GUCY1B3(8), GUCY2C(14), GUCY2D(7), GUCY2F(26), GUK1(7), HPRT1(2), IMPDH1(6), IMPDH2(5), ITPA(1), NME1(2), NME4(2), NME6(2), NME7(4), NPR1(12), NPR2(11), NT5C(1), NT5C1A(2), NT5C1B(8), NT5C2(6), NT5C3(8), NT5E(6), NT5M(3), NUDT2(2), NUDT5(2), NUDT9(1), PAICS(4), PAPSS1(8), PAPSS2(7), PDE10A(15), PDE11A(12), PDE1A(15), PDE1C(12), PDE2A(14), PDE3B(15), PDE4A(10), PDE4B(14), PDE4C(2), PDE4D(9), PDE5A(14), PDE6D(2), PDE6G(1), PDE6H(1), PDE7A(1), PDE7B(7), PDE8A(7), PDE8B(19), PDE9A(9), PFAS(11), PKLR(7), PKM2(5), PNPT1(7), POLA1(29), POLA2(3), POLD1(12), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), POLE3(3), POLE4(1), POLR1A(16), POLR1B(16), POLR1C(2), POLR1D(3), POLR2A(21), POLR2B(22), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(2), POLR2K(2), POLR3A(7), POLR3B(14), POLR3G(3), POLR3GL(3), POLR3H(5), PPAT(9), PRIM1(3), PRIM2(7), PRPS1(3), PRPS1L1(5), PRPS2(7), PRUNE(5), RFC5(8), RRM1(2), RRM2(7), RRM2B(5), XDH(14)	61621056	1067	129	1033	320	336	367	208	12	143	1	0.017	1.00	1.00
308	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	159	ADORA1(3), ADORA2A(6), ADORA2B(1), ADORA3(5), ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRA2A(6), ADRA2C(2), ADRB1(1), ADRB2(7), ADRB3(3), AGTR1(4), AGTR2(11), AVPR1A(7), AVPR1B(3), AVPR2(5), BDKRB1(3), BDKRB2(8), BRS3(17), C3AR1(9), CCBP2(3), CCKAR(9), CCKBR(3), CCR1(4), CCR10(1), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR6(5), CCR7(6), CCR8(6), CCR9(4), CCRL1(7), CCRL2(1), CHML(10), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), CMKLR1(9), CNR1(12), CNR2(6), CX3CR1(6), CXCR3(5), CXCR4(1), DRD1(7), DRD2(8), DRD3(6), DRD5(11), EDNRA(5), EDNRB(4), F2R(6), F2RL1(4), F2RL2(2), FPR1(2), FSHR(17), GALR1(3), GALR3(2), GALT(3), GHSR(8), GNB2L1(1), GPR17(6), GPR173(6), GPR174(12), GPR3(5), GPR35(3), GPR37(9), GPR37L1(6), GPR4(9), GPR50(8), GPR6(4), GPR63(5), GPR77(2), GPR83(3), GPR85(7), GPR87(7), GRPR(4), HCRTR2(11), HRH1(10), HRH2(4), HRH3(2), HTR1A(14), HTR1B(6), HTR1D(6), HTR1E(11), HTR1F(11), HTR2A(11), HTR2B(2), HTR2C(17), HTR4(8), HTR5A(12), HTR6(4), HTR7(5), LHCGR(17), LTB4R(2), MAS1(3), MC1R(3), MC3R(5), MC4R(5), MC5R(14), MLNR(5), MTNR1A(5), MTNR1B(4), NMBR(4), NMUR1(4), NMUR2(8), NPY1R(9), NPY2R(5), NPY5R(13), NTSR1(5), NTSR2(1), OPN1SW(6), OPN3(2), OPRD1(1), OPRK1(10), OPRL1(3), OPRM1(13), OR10A5(7), OR1F1(6), OR1Q1(4), OR5V1(9), OR7A5(4), OR7C1(9), OR8B8(8), OXTR(4), P2RY1(3), P2RY10(8), P2RY11(9), P2RY12(5), P2RY13(2), P2RY14(6), P2RY2(3), P2RY6(4), PPYR1(8), PTAFR(4), PTGDR(9), PTGER2(3), PTGER4(12), PTGFR(13), PTGIR(3), RGR(6), RHO(4), RRH(2), SSTR1(10), SSTR2(3), SSTR3(3), SSTR4(10), SUCNR1(3), TRHR(3)	43107856	933	127	901	326	308	387	157	11	70	0	0.0020	1.00	1.00
309	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	AKT1(4), AKT2(6), AKT3(11), ANKRD6(8), APC(56), AXIN1(9), AXIN2(9), CER1(4), CSNK1A1(4), CTNNB1(80), DACT1(14), DKK1(3), DKK2(3), DKK3(1), DKK4(3), DVL1(3), FSTL1(3), GSK3A(10), GSK3B(13), LRP1(51), MVP(14), NKD1(3), PSEN1(5), PTPRA(10), SENP2(12), SFRP1(6), TSHB(3), WIF1(5)	15233400	353	126	287	95	111	148	53	2	36	3	0.0087	1.00	1.00
310	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(4), ATF2(8), CDC42(4), DLD(5), DUSP10(5), DUSP8(1), GAB1(8), GCK(3), IL1R1(5), JUN(1), MAP2K4(9), MAP2K5(3), MAP2K7(4), MAP3K1(30), MAP3K10(7), MAP3K11(6), MAP3K12(8), MAP3K13(13), MAP3K2(12), MAP3K3(9), MAP3K4(21), MAP3K5(25), MAP3K7(9), MAP3K9(6), MAPK10(9), MAPK7(14), MAPK8(10), MAPK9(5), MYEF2(6), NFATC3(12), NR2C2(7), PAPPA(27), SHC1(7), TP53(74), TRAF6(7), ZAK(15)	18630752	399	123	371	98	128	136	67	4	61	3	0.015	1.00	1.00
311	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	86	ACVR1(11), ACVR1B(9), ACVR1C(6), ACVR2A(7), ACVR2B(5), ACVRL1(2), AMHR2(3), BMP2(6), BMP4(10), BMP5(14), BMP6(5), BMP7(12), BMP8A(3), BMP8B(1), BMPR1A(5), BMPR1B(6), BMPR2(12), CHRD(11), COMP(6), CREBBP(32), CUL1(13), DCN(11), E2F4(3), E2F5(6), EP300(32), FST(4), GDF5(7), GDF6(4), ID1(2), ID2(1), IFNG(9), INHBA(8), INHBB(2), INHBC(3), INHBE(6), LEFTY1(4), LEFTY2(1), LTBP1(17), MAPK1(2), MAPK3(3), MYC(8), NODAL(3), NOG(2), PITX2(12), PPP2CA(6), PPP2CB(4), PPP2R1A(30), PPP2R1B(6), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), RBL1(14), RBL2(19), RBX1(1), RHOA(3), ROCK1(22), ROCK2(17), RPS6KB1(5), RPS6KB2(4), SMAD1(2), SMAD2(9), SMAD3(7), SMAD4(5), SMAD5(11), SMAD7(3), SMAD9(2), SMURF1(12), SMURF2(7), SP1(7), TFDP1(13), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6), THBS1(11), THBS2(20), THBS3(3), THBS4(12), ZFYVE16(18), ZFYVE9(18)	36166832	671	122	637	185	236	222	123	4	82	4	0.0079	1.00	1.00
312	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	56	ASH1L(42), ASH2L(12), C17orf79(2), CARM1(5), CTCFL(13), DOT1L(8), EED(12), EHMT1(23), EZH1(10), EZH2(15), FBXO11(8), HCFC1(26), HSF4(3), JMJD4(4), JMJD6(5), KDM6A(14), MEN1(9), MLL(32), MLL2(57), MLL3(56), MLL4(54), MLL5(25), NSD1(37), OGT(17), PAXIP1(10), PPP1CA(3), PPP1CB(9), PPP1CC(4), PRDM2(19), PRDM6(6), PRDM7(2), PRDM9(31), PRMT1(4), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), RBBP5(7), SATB1(18), SETD1A(12), SETD1B(17), SETD2(36), SETD7(7), SETD8(3), SETDB1(16), SETDB2(14), SETMAR(6), SMYD3(6), STK38(9), SUV39H1(9), SUV39H2(5), SUV420H1(16), SUZ12(12), WHSC1(19), WHSC1L1(17)	46251752	833	121	808	235	257	277	159	10	124	6	0.031	1.00	1.00
313	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(5), ACTA2(7), ACTN2(16), ACTN3(10), ACTN4(8), DES(6), DMD(92), FAM48A(5), MYBPC1(16), MYBPC2(13), MYBPC3(13), MYH3(30), MYH6(16), MYH7(35), MYH8(30), MYL1(5), MYL2(2), MYL3(1), MYL9(3), MYOM1(36), NEB(123), TMOD1(4), TNNC2(3), TNNI1(1), TNNI2(4), TNNI3(4), TNNT1(4), TNNT2(8), TNNT3(4), TPM1(3), TPM2(1), TPM3(5), TPM4(4), TTN(526), VIM(8)	53089112	1051	121	1016	332	293	438	227	4	60	29	0.49	1.00	1.00
314	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADK(2), ADSL(8), ADSS(6), AK1(1), AK2(3), AK5(8), ALLC(8), AMPD1(23), AMPD2(6), AMPD3(7), ATIC(7), ATP1B1(6), ATP5A1(8), ATP5B(5), ATP5C1(1), ATP5D(1), ATP5F1(4), ATP5G1(3), ATP5G2(1), ATP5G3(1), ATP5H(1), ATP5I(2), ATP5J(3), CANT1(1), DCK(5), ENPP1(12), ENPP3(18), ENTPD1(3), FHIT(4), GART(9), GDA(4), GMPS(14), GUCY1A2(10), GUCY1A3(11), GUCY1B3(8), GUCY2C(14), GUCY2D(7), GUCY2F(26), GUK1(7), HPRT1(2), IMPDH1(6), IMPDH2(5), ITPA(1), NME1(2), NPR1(12), NPR2(11), NT5C(1), NT5E(6), NT5M(3), NUDT2(2), PAICS(4), PAPSS1(8), PAPSS2(7), PDE1A(15), PDE4A(10), PDE4B(14), PDE4C(2), PDE4D(9), PDE5A(14), PDE6B(5), PDE6C(13), PDE6G(1), PDE7B(7), PDE8A(7), PDE9A(9), PFAS(11), PKLR(7), PKM2(5), POLB(4), POLD1(12), POLD2(6), POLE(47), POLG(6), POLL(7), POLQ(29), POLR1B(16), POLR2A(21), POLR2B(22), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(2), POLR2K(2), POLRMT(11), PPAT(9), PRPS1(3), PRPS1L1(5), PRPS2(7), PRUNE(5), RRM1(2), RRM2(7)	47815888	830	117	805	257	264	303	155	6	101	1	0.085	1.00	1.00
315	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(4), AKT3(11), BCAR1(8), CAPN1(5), CAPN10(9), CAPN11(9), CAPN2(11), CAPN3(11), CAPN5(9), CAPN6(13), CAPN7(8), CAPN9(11), CAPNS1(2), CAV1(2), CAV2(1), CDC42(4), CRK(2), CSK(1), DOCK1(24), FYN(7), GIT2(9), GRB2(3), ILK(5), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(10), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(20), ITGA9(16), ITGAD(10), ITGAE(9), ITGAL(17), ITGAM(21), ITGAV(10), ITGAX(14), ITGB1(8), ITGB2(14), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K6(10), MAPK10(9), MAPK12(3), MAPK4(4), MAPK6(11), MAPK7(14), MYLK2(8), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PDPK1(3), PIK3R2(7), PTK2(12), PXN(6), RAC1(1), RAC2(3), RAP1B(2), RAPGEF1(11), RHO(4), ROCK1(22), ROCK2(17), SDCCAG8(13), SEPP1(3), SHC1(7), SHC3(15), SORBS1(18), SOS1(13), SRC(3), TLN1(23), TNS1(23), VASP(3), VAV2(7), VAV3(14), VCL(11), ZYX(11)	51128424	805	115	779	290	257	298	140	6	98	6	0.55	1.00	1.00
316	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	90	CD2BP2(2), CDC40(9), CLK2(9), CLK3(6), CLK4(6), COL2A1(15), CPSF1(11), CPSF2(14), CPSF3(8), CPSF4(1), CSTF1(4), CSTF2(13), CSTF2T(5), CSTF3(10), DDIT3(2), DDX1(5), DDX20(4), DHX15(9), DHX38(10), DHX8(9), DHX9(14), DICER1(36), DNAJC8(1), FUS(3), GIPC1(2), LOC440563(4), METTL3(6), NCBP1(9), NCBP2(4), NONO(18), NXF1(4), PABPN1(3), PAPOLA(13), PHF5A(1), POLR2A(21), PPM1G(9), PRPF18(5), PRPF3(10), PRPF4(5), PRPF4B(17), PRPF8(26), PSKH1(8), PTBP1(3), PTBP2(9), RBM17(4), RBM5(6), RNGTT(11), RNMT(7), RNPS1(3), SF3A1(4), SF3A2(2), SF3A3(8), SF3B1(18), SF3B2(9), SF3B4(4), SF3B5(2), SNRPA(2), SNRPB(2), SNRPB2(1), SNRPD1(1), SNRPD2(1), SNRPD3(3), SNRPE(1), SNRPG(1), SNRPN(4), SNURF(1), SPOP(23), SRPK1(11), SRPK2(6), SRRM1(12), SUPT5H(19), U2AF1(4), U2AF2(7), XRN2(19)	38955840	579	109	555	175	199	188	121	3	66	2	0.56	1.00	1.00
317	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	43	ABCA1(30), ABCA10(26), ABCA12(53), ABCA13(79), ABCA2(11), ABCA3(12), ABCA4(28), ABCA5(30), ABCA6(24), ABCA7(17), ABCA8(27), ABCA9(28), ABCB1(32), ABCB10(10), ABCB11(15), ABCB4(27), ABCB5(32), ABCB6(11), ABCB7(17), ABCB8(6), ABCB9(7), ABCC1(14), ABCC10(10), ABCC11(27), ABCC12(20), ABCC2(30), ABCC3(13), ABCC4(16), ABCC5(15), ABCC6(13), ABCC8(21), ABCC9(29), ABCD1(12), ABCD2(7), ABCD3(9), ABCD4(2), ABCG1(12), ABCG2(16), ABCG4(7), ABCG5(5), ABCG8(7), CFTR(14), TAP1(8)	44219144	829	108	801	227	229	332	148	3	107	10	0.000068	1.00	1.00
318	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(4), EGFR(12), IGF1R(13), MYC(8), POLR2A(21), PPP2CA(6), PRKCA(10), RB1(26), TEP1(13), TERF1(1), TERT(4), TNKS(15), TP53(74), XRCC5(8)	10491888	215	105	188	58	80	53	39	3	37	3	0.038	1.00	1.00
319	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(7), ALG1(2), ALG10(6), ALG10B(6), ALG11(6), ALG12(7), ALG13(24), ALG14(2), ALG2(2), ALG3(1), ALG6(5), ALG8(10), ALG9(4), B3GNT1(5), B3GNT2(1), B3GNT6(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), B4GALT5(2), B4GALT7(4), C1GALT1(2), C1GALT1C1(6), CHPF(5), CHST1(8), CHST11(8), CHST12(3), CHST14(3), CHST2(2), CHST3(4), CHST4(4), CHST6(6), CHST7(4), CHSY1(8), DAD1(2), DDOST(3), DPAGT1(3), EXT1(12), EXT2(6), EXTL1(9), EXTL2(8), EXTL3(10), FUT11(4), FUT8(13), GALNT1(10), GALNT10(8), GALNT11(12), GALNT12(6), GALNT13(18), GALNT14(6), GALNT2(9), GALNT3(7), GALNT4(8), GALNT5(7), GALNT6(1), GALNT7(13), GALNT8(11), GALNT9(8), GALNTL1(8), GALNTL2(17), GALNTL4(6), GALNTL5(11), GANAB(10), GCNT1(5), GCNT3(5), GCNT4(1), HS2ST1(7), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), HS3ST5(9), HS6ST1(4), HS6ST2(12), HS6ST3(3), MAN1A1(13), MAN1A2(7), MAN1B1(5), MAN1C1(6), MAN2A1(20), MGAT1(4), MGAT2(4), MGAT3(4), MGAT4A(5), MGAT4B(6), MGAT5(11), MGAT5B(10), NDST1(14), NDST2(9), NDST3(14), NDST4(15), OGT(17), RPN1(3), RPN2(5), ST3GAL1(2), ST3GAL2(6), ST3GAL3(10), ST3GAL4(3), ST6GAL1(7), ST6GALNAC1(4), STT3B(5), UST(3), WBSCR17(16), XYLT1(16), XYLT2(4)	39862280	740	103	715	231	237	261	152	3	84	3	0.095	1.00	1.00
320	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(9), ACTN2(16), ACTN3(10), BCAR1(8), CSK(1), CTNNA1(18), CTNNA2(16), CTNNB1(80), PTK2(12), PXN(6), SRC(3), VCL(11)	7316992	190	100	131	52	42	93	31	2	21	1	0.070	1.00	1.00
321	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(17), AMY2A(4), AMY2B(11), ASCC3(31), ATP13A2(5), DDX18(12), DDX19A(4), DDX23(9), DDX4(15), DDX41(3), DDX47(5), DDX50(10), DDX51(8), DDX52(4), DDX54(8), DDX55(7), DDX56(5), DHX58(6), ENPP1(12), ENPP3(18), ENTPD7(8), EP400(42), ERCC2(1), ERCC3(11), G6PC(5), G6PC2(11), GAA(4), GANC(15), GBA(4), GBA3(9), GBE1(9), GCK(3), GPI(7), GUSB(5), GYS1(13), GYS2(16), HK1(11), HK2(9), HK3(10), IFIH1(5), LYZL1(4), MGAM(51), MOV10L1(19), NUDT5(2), NUDT8(1), PGM1(7), PGM3(4), PYGB(11), PYGL(8), PYGM(10), RAD54B(14), RAD54L(5), RUVBL2(4), SETX(33), SI(65), SKIV2L2(17), SMARCA2(24), SMARCA5(19), TREH(2), UGDH(2), UGP2(6), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2A1(11), UGT2A3(5), UGT2B10(18), UGT2B11(18), UGT2B15(9), UGT2B17(7), UGT2B28(21), UGT2B4(11), UGT2B7(5), UXS1(5)	47065440	856	100	828	213	232	308	201	9	100	6	0.00038	1.00	1.00
322	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(8), BRAF(10), CHUK(8), CREB1(6), DAXX(10), ELK1(3), FOS(3), GRB2(3), HRAS(1), IKBKB(13), JUN(1), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K5(3), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K10(7), MAP3K11(6), MAP3K12(8), MAP3K13(13), MAP3K14(6), MAP3K2(12), MAP3K3(9), MAP3K4(21), MAP3K5(25), MAP3K6(7), MAP3K7(9), MAP3K8(10), MAP3K9(6), MAP4K1(11), MAP4K2(7), MAP4K3(16), MAP4K4(11), MAP4K5(7), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK4(4), MAPK6(11), MAPK7(14), MAPK8(10), MAPK9(5), MAPKAPK2(6), MAPKAPK3(5), MAPKAPK5(5), MAX(12), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), MKNK1(3), MKNK2(3), MYC(8), NFKB1(10), NFKBIA(3), PAK1(3), PAK2(3), RAC1(1), RAF1(8), RELA(6), RIPK1(9), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA4(2), RPS6KA5(11), RPS6KB1(5), RPS6KB2(4), SHC1(7), SP1(7), STAT1(15), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TRAF2(3)	36511800	615	100	599	162	190	226	108	4	83	4	0.0051	1.00	1.00
323	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(3), BAD(2), CABIN1(19), CALM1(2), CALM2(4), CAMK2B(3), CAMK4(5), CD3E(2), CD3G(3), CD69(2), CDKN1A(1), CNR1(12), CREBBP(32), CSF2(1), CSNK2A1(9), CTLA4(2), EGR2(6), EGR3(7), EP300(32), FCER1A(9), FCGR3A(1), FKBP1B(1), FOS(3), FOSL1(3), GATA3(3), GATA4(3), GSK3A(10), GSK3B(13), HRAS(1), ICOS(3), IFNA1(2), IFNB1(3), IFNG(9), IL10(3), IL1B(2), IL2(2), IL2RA(4), IL3(2), IL4(1), IL6(5), IL8(3), ITK(7), KPNA5(7), MAP2K7(4), MAPK14(4), MAPK8(10), MAPK9(5), MEF2A(3), MEF2B(1), MEF2D(7), MYF5(6), NCK2(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NFKB2(9), NFKBIB(1), NFKBIE(6), NPPB(3), NUP214(18), OPRD1(1), P2RX7(1), PAK1(3), PPIA(1), PPP3CB(5), PPP3CC(6), PPP3R1(1), PTPRC(17), RELA(6), RPL13A(1), SLA(6), SP1(7), SP3(11), TGFB1(2), TRAF2(3), TRPV6(10), VAV1(12), VAV2(7), VAV3(14), XPO5(11)	33810584	515	99	499	166	167	170	100	4	73	1	0.18	1.00	1.00
324	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(5), AK3(2), CAD(25), CANT1(1), CDA(2), CTPS(11), CTPS2(8), DCK(5), DCTD(4), DHODH(3), DPYD(20), DPYS(6), DTYMK(2), ENTPD1(3), ENTPD3(5), ENTPD4(2), ENTPD5(2), ENTPD6(10), ENTPD8(5), ITPA(1), NME1(2), NME4(2), NME6(2), NME7(4), NT5C(1), NT5C1A(2), NT5C1B(8), NT5C2(6), NT5C3(8), NT5E(6), NT5M(3), NUDT2(2), PNPT1(7), POLA1(29), POLA2(3), POLD1(12), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), POLE3(3), POLE4(1), POLR1A(16), POLR1B(16), POLR1C(2), POLR1D(3), POLR2A(21), POLR2B(22), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(2), POLR2K(2), POLR3A(7), POLR3B(14), POLR3G(3), POLR3GL(3), POLR3H(5), PRIM1(3), PRIM2(7), RFC5(8), RRM1(2), RRM2(7), RRM2B(5), TK1(3), TK2(6), TXNRD1(10), TXNRD2(5), UCK1(7), UCK2(5), UMPS(7), UPB1(10), UPP1(4), UPP2(4), UPRT(8)	30791184	518	99	497	157	156	182	102	5	72	1	0.10	1.00	1.00
325	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(18), BDKRB1(3), BDKRB2(8), C1QA(5), C1QB(3), C1QC(4), C1R(11), C1S(8), C2(3), C3(22), C3AR1(9), C4BPA(6), C4BPB(6), C5(18), C5AR1(3), C6(16), C7(20), C8A(9), C8B(5), C8G(1), C9(19), CD46(3), CD55(7), CD59(4), CFB(3), CFH(22), CFI(8), CPB2(7), CR1(22), CR2(24), F10(14), F11(15), F12(2), F13A1(8), F13B(17), F2(8), F2R(6), F3(6), F5(48), F7(2), F8(45), F9(14), FGA(26), FGB(7), FGG(10), KLKB1(10), KNG1(12), MASP1(15), MASP2(7), MBL2(4), PLAT(6), PLAU(6), PLAUR(7), PLG(14), PROC(5), PROS1(21), SERPINA1(4), SERPINA5(5), SERPINC1(10), SERPIND1(7), SERPINE1(5), SERPINF2(4), SERPING1(7), TFPI(9), THBD(1), VWF(25)	33366416	709	96	680	205	183	309	120	4	88	5	0.024	1.00	1.00
326	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	ACTG1(6), APAF1(17), ARHGDIB(3), BAG4(5), BID(2), BIRC2(10), BIRC3(5), CASP2(6), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CFLAR(6), CHUK(8), CRADD(3), CYCS(2), DAXX(10), DFFB(4), FADD(1), GSN(5), LMNA(8), LMNB1(5), LMNB2(4), MAP2K7(4), MAP3K1(30), MAP3K14(6), MAP3K5(25), MAPK8(10), MDM2(4), NFKB1(10), NFKBIA(3), NUMA1(21), PAK2(3), PRKCD(5), PRKDC(54), PSEN1(5), PSEN2(8), PTK2(12), RASA1(30), RB1(26), RELA(6), RIPK1(9), SPTAN1(31), TNFRSF1A(4), TNFRSF1B(2), TRAF1(5), TRAF2(3)	26079928	465	95	452	132	122	167	82	6	83	5	0.17	1.00	1.00
327	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(15), CD14(2), CD19(4), CD1A(5), CD1B(2), CD1C(14), CD1D(5), CD1E(6), CD2(4), CD22(14), CD33(6), CD34(1), CD36(8), CD37(1), CD38(6), CD3D(6), CD3E(2), CD3G(3), CD4(6), CD44(5), CD5(10), CD55(7), CD59(4), CD7(3), CD8A(2), CD8B(1), CD9(4), CR1(22), CR2(24), CSF1(6), CSF1R(8), CSF2(1), CSF2RA(12), CSF3(1), CSF3R(8), DNTT(3), EPO(2), EPOR(4), FCER2(1), FCGR1A(6), FLT3(16), FLT3LG(2), GP5(3), GYPA(2), HLA-DRB5(2), IL11(2), IL11RA(5), IL1B(2), IL1R1(5), IL1R2(5), IL2RA(4), IL3(2), IL3RA(9), IL4(1), IL4R(6), IL5(2), IL5RA(9), IL6(5), IL6R(7), IL7(1), IL7R(12), IL9R(8), ITGA1(17), ITGA2(19), ITGA2B(10), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGAM(21), ITGB3(11), KIT(24), KITLG(3), MME(11), MS4A1(7), TFRC(4), THPO(7), TPO(15)	30444232	542	93	532	185	140	214	101	3	81	3	0.37	1.00	1.00
328	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	68	ACACB(29), ACSL1(14), ACSL3(7), ACSL4(21), ACSL5(9), ACSL6(12), ADIPOQ(2), ADIPOR1(3), ADIPOR2(7), AGRP(2), AKT1(4), AKT2(6), AKT3(11), CAMKK1(13), CAMKK2(7), CD36(8), CHUK(8), CPT1A(9), CPT1B(6), CPT1C(15), CPT2(4), G6PC(5), G6PC2(11), IKBKB(13), IKBKG(4), IRS1(13), IRS4(21), JAK1(20), JAK2(17), JAK3(10), LEP(2), LEPR(12), MAPK10(9), MAPK8(10), MAPK9(5), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NPY(2), PCK1(9), PCK2(7), POMC(4), PPARA(1), PPARGC1A(9), PRKAA1(8), PRKAA2(10), PRKAB1(6), PRKAB2(1), PRKAG1(3), PRKAG2(4), PRKAG3(6), PRKCQ(9), PTPN11(8), RELA(6), RXRA(3), RXRG(8), SLC2A1(2), SLC2A4(9), STAT3(10), STK11(2), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3), TYK2(10)	30150104	524	90	512	189	153	200	96	5	64	6	0.56	1.00	1.00
329	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(12), CD28(3), CD3D(6), CSK(1), CTLA4(2), DAG1(6), DTYMK(2), EPHB2(12), FBXW7(46), GRB2(3), ITK(7), ITPKA(1), ITPKB(12), LCK(5), LCP2(5), MAPK1(2), NCK1(4), NFAT5(16), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PLCG1(12), PTPRC(17), RAF1(8), RASGRP1(8), RASGRP2(4), RASGRP3(13), RASGRP4(6), SOS1(13), SOS2(17), VAV1(12), ZAP70(9)	20759088	329	89	305	115	103	119	55	4	46	2	0.67	1.00	1.00
330	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(5), ALG6(5), CCKBR(3), CCR2(5), CCR3(4), CCR5(6), CELSR1(23), CELSR2(22), CELSR3(28), CHRM2(10), CHRM3(8), CIDEB(2), CXCR3(5), EDNRA(5), EMR2(6), EMR3(4), F2R(6), FSHR(17), GHRHR(2), GNRHR(4), GPR116(21), GPR132(6), GPR133(16), GPR135(4), GPR143(4), GPR17(6), GPR18(3), GPR55(3), GPR56(3), GPR61(4), GPR77(2), GPR84(3), GPR88(1), GRM1(29), GRPR(4), HRH4(5), LGR6(13), LPHN2(22), LPHN3(22), LTB4R2(4), NTSR1(5), OR2M4(4), OR8G2(5), P2RY11(9), P2RY13(2), PTGFR(13), SMO(9), SSTR2(3), TAAR5(5), TSHR(8), VN1R1(5)	24522736	413	86	407	160	123	176	64	3	46	1	0.46	1.00	1.00
331	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	ADAM17(11), CREBBP(32), CTBP1(1), CTBP2(5), DLL1(7), DLL3(6), DLL4(6), DTX1(7), DTX2(4), DTX3(5), DTX3L(7), DTX4(4), DVL1(3), DVL2(10), DVL3(9), EP300(32), HDAC1(5), HDAC2(5), HES1(1), JAG1(23), JAG2(2), LFNG(2), MAML1(6), MAML2(10), MAML3(14), MFNG(3), NCOR2(23), NCSTN(9), NOTCH1(11), NOTCH2(18), NOTCH3(29), NUMB(9), NUMBL(4), PSEN1(5), PSEN2(8), RBPJ(5), RBPJL(9), SNW1(6)	24773216	356	86	347	124	132	107	59	5	52	1	0.29	1.00	1.00
332	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(2), CAD(25), CANT1(1), CDA(2), CTPS(11), CTPS2(8), DCK(5), DCTD(4), DHODH(3), DPYD(20), DPYS(6), DTYMK(2), ENTPD1(3), ITPA(1), NME1(2), NT5C(1), NT5E(6), NT5M(3), NUDT2(2), POLB(4), POLD1(12), POLD2(6), POLE(47), POLG(6), POLL(7), POLQ(29), POLR1B(16), POLR2A(21), POLR2B(22), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(2), POLR2K(2), POLRMT(11), RRM1(2), RRM2(7), TK1(3), TK2(6), TXNRD1(10), UCK1(7), UCK2(5), UMPS(7), UNG(3), UPB1(10), UPP1(4)	21350072	370	86	352	108	112	144	66	1	46	1	0.070	1.00	1.00
333	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(4), AKT2(6), AKT3(11), ASAH1(7), BRAF(10), DAG1(6), DRD2(8), EGFR(12), EPHB2(12), GRB2(3), ITPKA(1), ITPKB(12), ITPR1(36), ITPR2(35), ITPR3(21), KCNJ3(9), KCNJ5(7), KCNJ9(4), MAPK1(2), PI3(2), PIK3CB(17), PITX2(12), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), RAF1(8), RGS20(2), SHC1(7), SOS1(13), SOS2(17), SRC(3), STAT3(10), TERF2IP(2)	21867400	342	84	330	139	107	130	58	5	40	2	0.92	1.00	1.00
334	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM10(4), ADAM17(11), ATP6AP1(8), ATP6V0A1(7), ATP6V0A2(12), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(11), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), CASP3(4), CCL5(2), CDC42(4), CHUK(8), CSK(1), CXCL1(3), EGFR(12), F11R(1), GIT1(9), HBEGF(2), IGSF5(6), IKBKB(13), IKBKG(4), IL8(3), JAM2(9), JAM3(3), JUN(1), LYN(9), MAP2K4(9), MAP3K14(6), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK8(10), MAPK9(5), MET(17), NFKB1(10), NFKB2(9), NFKBIA(3), NOD1(9), PAK1(3), PLCG1(12), PLCG2(29), PTPN11(8), PTPRZ1(46), RAC1(1), RELA(6), SRC(3), TCIRG1(6), TJP1(24)	26682320	474	83	467	148	123	194	84	2	68	3	0.22	1.00	1.00
335	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(4), APC(56), ASAH1(7), CAMP(1), DAG1(6), DLG4(11), EPHB2(12), GNAI1(5), GNAQ(3), ITPR1(36), ITPR2(35), ITPR3(21), KCNJ3(9), KCNJ5(7), KCNJ9(4), MAPK1(2), PITX2(12), PTX3(2), RAC1(1), RHO(4), RYR1(72)	17280888	311	83	299	130	87	145	37	3	35	4	0.85	1.00	1.00
336	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(17), CARM1(5), CCND1(15), CREBBP(32), EP300(32), ERCC3(11), ESR1(11), GRIP1(12), GTF2A1(3), GTF2E1(3), GTF2F1(7), HDAC1(5), HDAC2(5), HDAC3(12), HDAC4(14), HDAC5(12), HDAC6(25), MEF2C(11), NCOR2(23), NR0B1(8), NRIP1(17), PELP1(11), POLR2A(21), SRA1(1), TBP(3)	17853024	316	82	302	88	115	94	57	1	48	1	0.021	1.00	1.00
337	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	46	AADAT(6), AASDHPPT(9), AASS(12), ACAT1(6), ACAT2(4), AKR1B10(4), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), BBOX1(1), DLST(9), DOT1L(8), ECHS1(3), EHHADH(11), EHMT1(23), GCDH(6), HADH(1), HADHA(5), HSD17B10(4), HSD17B4(13), HSD3B7(5), NSD1(37), OGDH(13), OGDHL(19), PIPOX(4), PLOD1(4), PLOD2(13), PLOD3(7), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SETD1A(12), SETD7(7), SETDB1(16), SHMT1(5), SHMT2(5), SPCS3(2), SUV39H1(9), SUV39H2(5), TMLHE(6)	20652696	337	82	326	109	116	113	68	9	30	1	0.20	1.00	1.00
338	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(6), BMP4(10), BMP5(14), BMP6(5), BMP7(12), BMP8A(3), BMP8B(1), BTRC(14), CSNK1A1(4), CSNK1A1L(4), CSNK1D(3), CSNK1E(3), CSNK1G1(6), CSNK1G2(2), CSNK1G3(8), DHH(2), FBXW11(5), GLI1(13), GLI2(10), GLI3(28), GSK3B(13), HHIP(13), IHH(3), LRP2(92), PRKACA(6), PRKACB(3), PRKACG(9), PRKX(2), PTCH1(23), PTCH2(12), RAB23(4), SHH(4), SMO(9), STK36(6), SUFU(3), WNT1(1), WNT10A(2), WNT10B(2), WNT11(6), WNT16(7), WNT2(3), WNT2B(8), WNT3(3), WNT3A(1), WNT4(1), WNT5A(7), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2), WNT8A(2), WNT8B(5), WNT9A(4), WNT9B(2), ZIC2(1)	21655856	419	82	408	143	156	160	57	4	40	2	0.22	1.00	1.00
339	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(4), AGTR2(11), ATP8A1(15), AVPR1A(7), AVPR1B(3), AVPR2(5), BDKRB1(3), BDKRB2(8), BRS3(17), C3AR1(9), CCKAR(9), CCKBR(3), CCR1(4), CCR10(1), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR6(5), CCR7(6), CCR8(6), CX3CR1(6), CXCR3(5), CXCR4(1), CXCR6(1), EDNRA(5), EDNRB(4), FPR1(2), FSHR(17), GALR1(3), GALR3(2), GALT(3), GHSR(8), GNB2L1(1), GNRHR(4), GPR77(2), GRPR(4), LHCGR(17), MC1R(3), MC2R(4), MC3R(5), MC4R(5), MC5R(14), NMBR(4), NPY1R(9), NPY2R(5), NPY5R(13), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(10), OPRL1(3), OPRM1(13), OXTR(4), PPYR1(8), SSTR1(10), SSTR2(3), SSTR3(3), SSTR4(10), TACR1(7), TACR2(3), TACR3(9), TRHR(3), TSHR(8)	18884456	384	81	372	142	116	168	51	6	43	0	0.12	1.00	1.00
340	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(17), AMY2A(4), AMY2B(11), ENPP1(12), ENPP3(18), G6PC(5), GAA(4), GANAB(10), GBA3(9), GBE1(9), GCK(3), GPI(7), GUSB(5), GYS1(13), GYS2(16), HK1(11), HK2(9), HK3(10), MGAM(51), PGM1(7), PGM3(4), PYGB(11), PYGL(8), PYGM(10), RNPC3(6), SI(65), UCHL1(4), UCHL3(1), UGDH(2), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2B15(9), UGT2B4(11), UXS1(5)	21706200	413	81	408	107	101	155	96	5	56	0	0.022	1.00	1.00
341	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(22), ATP4A(9), ATP4B(4), ATP5A1(8), ATP5B(5), ATP5C1(1), ATP5D(1), ATP5E(2), ATP5F1(4), ATP5G1(3), ATP5G2(1), ATP5G3(1), ATP5H(1), ATP5I(2), ATP5J(3), ATP5L(1), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A2(12), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(11), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), COX10(3), COX15(3), COX17(1), COX4I1(3), COX5A(1), COX5B(1), COX6A1(3), COX6A2(1), COX6B1(1), COX6C(3), COX7A1(3), COX7B(4), COX7B2(3), COX7C(2), COX8A(1), COX8C(1), CYC1(3), LHPP(2), NDUFA1(1), NDUFA10(7), NDUFA13(1), NDUFA2(3), NDUFA3(4), NDUFA4(1), NDUFA4L2(1), NDUFA5(4), NDUFA6(2), NDUFA8(5), NDUFA9(5), NDUFAB1(2), NDUFB1(1), NDUFB10(1), NDUFB11(3), NDUFB7(3), NDUFB8(1), NDUFC1(1), NDUFC2(1), NDUFS1(13), NDUFS2(7), NDUFS4(3), NDUFS5(1), NDUFS7(2), NDUFS8(3), NDUFV1(3), NDUFV2(2), PPA1(4), PPA2(5), SDHA(15), SDHB(2), SDHC(4), SDHD(3), TCIRG1(6), UQCRB(4), UQCRC1(2), UQCRC2(7), UQCRFS1(3), UQCRH(1), UQCRQ(2)	21253352	373	80	369	103	121	140	54	2	55	1	0.018	1.00	1.00
342	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(6), AANAT(2), ABP1(5), ACAT1(6), ACAT2(4), ACMSD(8), AFMID(6), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), AOC2(7), AOC3(10), AOX1(18), ASMT(5), CARM1(5), CAT(4), CYP1A1(12), CYP1A2(11), CYP1B1(2), DDC(9), ECHS1(3), EHHADH(11), GCDH(6), HAAO(2), HADH(1), HADHA(5), HEMK1(3), HSD17B10(4), HSD17B4(13), INMT(2), KMO(11), KYNU(7), LCMT1(2), LCMT2(9), LNX1(9), MAOA(12), MAOB(7), METTL2B(4), METTL6(5), NFX1(15), OGDH(13), OGDHL(19), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), TDO2(3), TPH1(9), TPH2(4), WARS(6), WARS2(3), WBSCR22(5)	22537248	384	80	372	112	112	147	77	6	40	2	0.044	1.00	1.00
343	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACAA1(5), ACADL(8), ACADM(9), ACOX1(7), ACOX2(8), ACOX3(8), ACSL1(14), ACSL3(7), ACSL4(21), ACSL5(9), ACSL6(12), ADIPOQ(2), APOA1(3), APOA2(2), APOA5(2), APOC3(1), AQP7(4), CD36(8), CPT1A(9), CPT1B(6), CPT1C(15), CPT2(4), CYP27A1(9), CYP4A11(7), CYP4A22(7), CYP7A1(11), CYP8B1(4), DBI(1), EHHADH(11), FABP1(4), FABP2(2), FABP3(1), FABP4(2), FABP5(3), FABP6(3), FABP7(2), FADS2(2), GK(17), GK2(20), HMGCS2(9), ILK(5), LPL(16), ME1(12), MMP1(3), NR1H3(4), OLR1(2), PCK1(9), PCK2(7), PDPK1(3), PLTP(7), PPARA(1), PPARD(3), PPARG(6), RXRA(3), RXRG(8), SCD(6), SCP2(9), SLC27A1(10), SLC27A2(3), SLC27A4(5), SLC27A5(3), SLC27A6(10), SORBS1(18), UBC(8), UCP1(2)	23958536	442	80	433	131	135	167	89	1	50	0	0.065	1.00	1.00
344	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ABP1(5), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), ALDH1A3(8), ALDH3A1(7), ALDH3B2(7), AOC2(7), AOC3(10), AOX1(18), CARM1(5), COMT(3), DBH(9), DCT(12), DDC(9), ECH1(2), ESCO1(16), ESCO2(8), FAH(6), GOT1(9), GOT2(3), GSTZ1(5), HEMK1(3), HGD(4), HPD(7), LCMT1(2), LCMT2(9), MAOA(12), MAOB(7), METTL2B(4), METTL6(5), NAT6(1), PNMT(2), PNPLA3(7), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), SH3GLB1(7), TAT(7), TH(3), TPO(15), TYR(12), TYRP1(7), WBSCR22(5)	21946512	348	78	338	96	100	129	66	4	49	0	0.025	1.00	1.00
345	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AGK(10), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(6), AKR1A1(1), AKR1B1(1), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), CEL(5), DAK(4), DGAT1(3), DGAT2(6), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKI(20), DGKQ(2), DGKZ(10), GK(17), GK2(20), GLA(9), GLB1(6), GPAM(9), LCT(32), LIPA(8), LIPC(8), LIPF(7), LIPG(7), LPL(16), MGLL(2), PNLIP(6), PNLIPRP1(5), PNLIPRP2(9), PNPLA3(7), PPAP2A(6), PPAP2B(3), PPAP2C(1)	22096800	405	77	396	132	126	152	85	3	38	1	0.15	1.00	1.00
346	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	EEF1A2(4), EEF1B2(3), EEF1D(8), EEF1G(5), EEF2(13), EEF2K(11), EIF1AX(4), EIF2AK1(8), EIF2AK2(13), EIF2AK3(12), EIF2B2(5), EIF2B3(7), EIF2B4(4), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), EIF4A1(5), EIF4A2(9), EIF4E(2), EIF4EBP2(1), EIF4G1(15), EIF4G3(24), EIF5(3), EIF5A(5), EIF5B(15), ETF1(7), GSPT2(18), KIAA0664(13), PABPC1(11), PABPC3(9), PAIP1(6), SLC35A4(5)	16717928	267	76	260	65	87	92	43	6	35	4	0.0084	1.00	1.00
347	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(8), AGTR2(11), CALM1(2), CALM2(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CDK5(2), F2(8), FYN(7), GNA11(2), GNAI1(5), GNB1(2), GNGT1(1), GRB2(3), HRAS(1), JAK2(17), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(10), MAPT(9), MYLK(14), PLCG1(12), PRKCA(10), PTK2B(16), RAF1(8), SHC1(7), SOS1(13), STAT1(15), STAT3(10), STAT5A(5), SYT1(4)	15717496	244	74	235	89	87	84	44	1	25	3	0.58	1.00	1.00
348	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(12), ADCY6(14), ADCY8(22), CACNA1A(20), CACNA1B(35), GNAS(24), GNAT3(8), GNB1(2), GNB3(2), GNG13(2), GNG3(2), GRM4(12), ITPR3(21), KCNB1(13), PDE1A(15), PLCB2(8), PRKACA(6), PRKACB(3), PRKACG(9), PRKX(2), SCNN1A(3), SCNN1B(5), SCNN1G(9), TAS1R1(10), TAS1R2(11), TAS1R3(4), TAS2R1(4), TAS2R10(9), TAS2R13(3), TAS2R14(6), TAS2R16(4), TAS2R3(4), TAS2R38(5), TAS2R39(9), TAS2R4(3), TAS2R40(5), TAS2R41(4), TAS2R42(4), TAS2R43(1), TAS2R46(2), TAS2R5(4), TAS2R50(4), TAS2R60(6), TAS2R7(3), TAS2R8(6), TAS2R9(3), TRPM5(9)	21601792	372	74	365	146	125	140	71	2	34	0	0.71	1.00	1.00
349	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(8), CDC42(4), CREB1(6), DAXX(10), DDIT3(2), ELK1(3), GRB2(3), HMGN1(2), HRAS(1), HSPB2(1), MAP2K4(9), MAP2K6(10), MAP3K1(30), MAP3K5(25), MAP3K7(9), MAP3K9(6), MAPK14(4), MAPKAPK2(6), MAPKAPK5(5), MAX(12), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), MKNK1(3), MYC(8), PLA2G4A(13), RAC1(1), RIPK1(9), RPS6KA5(11), SHC1(7), STAT1(15), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TRAF2(3)	13812112	269	74	260	65	75	106	52	1	34	1	0.024	1.00	1.00
350	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(6), ACTR2(6), ACTR3(1), AKT1(4), ANGPTL2(6), CDC42(4), CFL1(1), CFL2(8), FLNA(39), FLNC(36), FSCN1(5), FSCN3(5), GDI1(4), GDI2(1), LIMK1(8), MYH2(43), MYLK(14), MYLK2(8), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PFN1(1), PFN2(2), RHO(4), ROCK1(22), ROCK2(17), RPS4X(1), VASP(3), WASF1(3), WASL(9)	17706208	297	74	294	89	90	125	43	3	34	2	0.027	1.00	1.00
351	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(3), CDC7(11), CDK2(2), CDT1(3), DIAPH2(31), GMNN(2), MCM10(8), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), NACA(21), PCNA(3), POLA2(3), POLD1(12), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), PRIM1(3), RFC1(21), RFC2(4), RFC3(4), RFC4(5), RFC5(8), RPA1(6), RPA2(3), RPA3(3), RPA4(4), RPS27A(4), UBA52(1), UBB(2), UBC(8)	18910248	286	73	265	74	75	135	39	3	32	2	0.062	1.00	1.00
352	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(22), ATP4B(4), ATP5E(2), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), ATP7A(29), ATP7B(13), COX10(3), COX4I1(3), COX5A(1), COX5B(1), COX6A1(3), COX6A2(1), COX6B1(1), COX6C(3), COX7A1(3), COX7B(4), COX7C(2), COX8A(1), NDUFA1(1), NDUFA10(7), NDUFA4(1), NDUFA5(4), NDUFA8(5), NDUFB7(3), NDUFS1(13), NDUFS2(7), NDUFV1(3), NDUFV2(2), PPA2(5), SDHA(15), SDHB(2), SHMT1(5), UQCRB(4), UQCRC1(2), UQCRFS1(3), UQCRH(1)	14521392	279	73	275	73	80	112	40	2	44	1	0.018	1.00	1.00
353	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(4), AKT2(6), AKT3(11), ARHGEF11(20), CDC42(4), DLG4(11), GNA13(7), IKBKG(4), LPA(16), MAP2K4(9), MAP3K1(30), MAP3K5(25), MAPK8(10), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), PDK1(2), PHKA2(21), PI3(2), PIK3CB(17), PLD1(14), PLD2(10), PLD3(5), PTK2(12), RDX(16), ROCK1(22), ROCK2(17), SERPINA4(4), SRF(3)	18301656	331	73	319	84	102	108	57	0	61	3	0.031	1.00	1.00
354	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AGPAT2(2), AGPAT3(4), AGPAT4(5), AKR1A1(1), AKR1B1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), CEL(5), DGAT1(3), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKQ(2), DGKZ(10), GK(17), GLA(9), GLB1(6), LCT(32), LIPC(8), LIPF(7), LIPG(7), LPL(16), PNLIP(6), PNLIPRP1(5), PNLIPRP2(9), PPAP2A(6), PPAP2B(3), PPAP2C(1)	18145664	332	72	328	102	101	121	75	3	32	0	0.072	1.00	1.00
355	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(29), POLA2(3), POLB(4), POLD1(12), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), POLE3(3), POLE4(1), POLG(6), POLG2(3), POLH(12), POLI(7), POLK(11), POLL(7), POLM(8), POLQ(29), PRIM1(3), PRIM2(7), REV1(13), REV3L(35), RFC5(8)	15583080	265	72	246	61	62	111	49	3	39	1	0.051	1.00	1.00
356	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	43	CHUK(8), DAXX(10), EGF(20), EGFR(12), ETS1(6), ETS2(6), FOS(3), HOXA7(8), HRAS(1), IKBKB(13), JUN(1), MAP2K1(2), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K14(6), MAP3K5(25), MAPK1(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(10), NFKB1(10), NFKBIA(3), PPP2CA(6), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCQ(9), RAF1(8), RELA(6), RIPK1(9), SP1(7), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3)	18152112	314	72	306	94	90	113	58	2	49	2	0.13	1.00	1.00
357	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(18), AR(14), ESR1(11), ESR2(5), ESRRA(2), HNF4A(13), NPM1(3), NR0B1(8), NR1D1(3), NR1D2(2), NR1H2(3), NR1H3(4), NR1I2(3), NR1I3(6), NR2C2(7), NR2E1(8), NR2F1(7), NR2F2(5), NR2F6(4), NR3C1(18), NR4A1(5), NR4A2(11), NR5A1(3), NR5A2(13), PGR(13), PPARA(1), PPARD(3), PPARG(6), RARA(2), RARB(4), RARG(6), ROR1(10), RORA(11), RORC(8), RXRA(3), RXRG(8), THRA(6), THRB(4), VDR(8)	15109896	269	72	258	85	97	97	49	3	22	1	0.15	1.00	1.00
358	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(5), ACSS2(8), ACYP1(2), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1A1(1), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH3B2(7), ALDH7A1(2), ALDH9A1(2), ALDOA(5), ALDOB(9), ALDOC(3), BPGM(1), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), G6PC2(11), GALM(1), GAPDH(3), GAPDHS(10), GCK(3), GPI(7), HK1(11), HK2(9), HK3(10), LDHA(8), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(4), PDHA1(7), PDHA2(10), PDHB(3), PFKL(8), PFKM(9), PFKP(8), PGAM1(3), PGAM2(1), PGAM4(5), PGK1(7), PGK2(6), PGM1(7), PGM3(4), PKLR(7), PKM2(5), TPI1(2)	21818048	325	71	321	112	103	124	59	2	37	0	0.36	1.00	1.00
359	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(2), B3GALNT1(6), B3GALT1(12), B3GALT2(8), B3GALT4(3), B3GALT5(4), B3GNT1(5), B3GNT2(1), B3GNT3(5), B3GNT4(4), B3GNT5(6), B4GALNT1(6), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), B4GALT6(6), FUT1(4), FUT2(1), FUT3(8), FUT4(3), FUT5(1), FUT6(10), FUT7(2), FUT9(9), GBGT1(7), GCNT2(11), PIGA(8), PIGB(11), PIGC(3), PIGF(2), PIGG(6), PIGH(5), PIGK(9), PIGL(1), PIGM(1), PIGN(13), PIGO(9), PIGP(3), PIGQ(5), PIGS(1), PIGT(7), PIGU(3), PIGV(7), PIGX(2), PIGZ(5), ST3GAL1(2), ST3GAL2(6), ST3GAL3(10), ST3GAL4(3), ST3GAL5(5), ST3GAL6(6), ST6GALNAC3(8), ST6GALNAC4(4), ST6GALNAC5(2), ST6GALNAC6(6), ST8SIA1(2), ST8SIA5(8), UGCG(4)	18280824	313	71	306	74	106	119	52	2	34	0	0.00035	1.00	1.00
360	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(5), AKT1(4), BDKRB2(8), CALM1(2), CALM2(4), CAV1(2), CHRM1(6), CHRNA1(7), FLT1(20), FLT4(9), KDR(26), NOS3(11), PDE2A(14), PDE3A(19), PDE3B(15), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKG1(11), PRKG2(11), RYR2(110), SLC7A1(8), SYT1(4), TNNI1(1)	15879440	324	71	316	112	94	122	62	3	39	4	0.37	1.00	1.00
361	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(8), AKT1(4), AKT2(6), AKT3(11), DAG1(6), GNAQ(3), IKBKG(4), ITPKA(1), ITPKB(12), ITPR1(36), ITPR2(35), ITPR3(21), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), PDK1(2), PHKA2(21), PIK3CB(17), PITX2(12), PLD1(14), PLD2(10), PLD3(5), VN1R1(5)	16990976	262	71	253	91	83	100	34	1	43	1	0.37	1.00	1.00
362	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(4), BTK(12), CALM1(2), CALM2(4), CD79A(1), CD79B(2), ELK1(3), FOS(3), GRB2(3), HRAS(1), JUN(1), LYN(9), MAP2K1(2), MAP3K1(30), MAPK14(4), MAPK3(3), MAPK8(10), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKCA(10), RAC1(1), RAF1(8), SHC1(7), SOS1(13), SYK(4), SYT1(4), VAV1(12)	14007784	222	70	213	72	67	80	47	1	26	1	0.44	1.00	1.00
363	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1C4(6), AKR1D1(8), ARSD(6), ARSE(10), CARM1(5), CYP11B1(8), CYP11B2(9), CYP19A1(13), HEMK1(3), HSD11B1(6), HSD17B1(4), HSD17B12(4), HSD17B2(2), HSD17B3(6), HSD17B7(5), HSD3B1(3), HSD3B2(6), LCMT1(2), LCMT2(9), METTL2B(4), METTL6(5), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), SRD5A1(6), SRD5A2(6), STS(8), SULT1E1(9), SULT2A1(7), SULT2B1(4), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2A1(11), UGT2A3(5), UGT2B10(18), UGT2B11(18), UGT2B15(9), UGT2B17(7), UGT2B28(21), UGT2B4(11), UGT2B7(5), WBSCR22(5)	18520888	360	70	345	97	80	169	58	3	48	2	0.022	1.00	1.00
364	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(8), AARS2(7), CARS(9), CARS2(5), DARS(7), DARS2(10), EARS2(5), EPRS(15), FARS2(2), FARSA(6), FARSB(7), GARS(8), HARS(5), HARS2(7), IARS(8), IARS2(20), KARS(5), LARS(19), LARS2(8), MARS(11), MARS2(4), NARS(11), NARS2(10), PARS2(4), QARS(7), RARS(13), RARS2(8), SARS(4), SARS2(6), TARS(9), TARS2(10), VARS(6), VARS2(1), WARS(6), WARS2(3), YARS(5), YARS2(3)	19129728	282	70	277	90	89	112	52	3	26	0	0.59	1.00	1.00
365	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRA2A(6), ADRA2C(2), ADRB1(1), ADRB2(7), ADRB3(3), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), DRD1(7), DRD2(8), DRD3(6), DRD5(11), HRH1(10), HRH2(4), HTR1A(14), HTR1B(6), HTR1D(6), HTR1E(11), HTR1F(11), HTR2A(11), HTR2B(2), HTR2C(17), HTR4(8), HTR5A(12), HTR6(4), HTR7(5)	9450288	233	70	225	82	92	85	42	3	11	0	0.047	1.00	1.00
366	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(40), B3GALT4(3), CDR1(2), DGKI(20), FAU(2), IL6ST(11), MRPL19(6), PIGK(9), RPL10(5), RPL11(3), RPL13(1), RPL13A(1), RPL14(8), RPL15(2), RPL17(6), RPL18(4), RPL18A(2), RPL19(4), RPL21(3), RPL22(4), RPL23(1), RPL24(2), RPL27(1), RPL27A(3), RPL28(3), RPL29(2), RPL3(2), RPL34(1), RPL35A(2), RPL37(3), RPL38(1), RPL39(4), RPL3L(3), RPL4(4), RPL5(7), RPL6(3), RPL7(1), RPL7A(2), RPL8(2), RPL9(2), RPLP0(5), RPS10(1), RPS11(1), RPS12(2), RPS13(1), RPS15(1), RPS16(1), RPS18(3), RPS20(3), RPS21(3), RPS24(2), RPS25(2), RPS27(1), RPS27A(4), RPS28(1), RPS29(2), RPS3(3), RPS3A(1), RPS4X(1), RPS6(7), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA6(19), RPS6KB1(5), RPS6KB2(4), RPS7(5), RPS8(2), RPS9(1), RPSA(1), SLC36A2(6), TBC1D10C(1), TSPAN9(4), UBA52(1), UBB(2), UBC(8)	19706328	323	70	307	109	88	117	67	3	46	2	0.90	1.00	1.00
367	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(3), BAG4(5), CASP2(6), CASP3(4), CASP8(21), CRADD(3), DFFB(4), FADD(1), JUN(1), LMNA(8), LMNB1(5), LMNB2(4), MADD(17), MAP2K4(9), MAP3K1(30), MAP3K7(9), MAPK8(10), PAK1(3), PAK2(3), PRKDC(54), RB1(26), RIPK1(9), SPTAN1(31), TNFRSF1A(4), TRAF2(3)	14625304	273	70	265	86	77	80	52	4	56	4	0.57	1.00	1.00
368	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(9), ACAA1(5), ACAA2(3), ACADM(9), ACADS(4), ACAT1(6), ACAT2(4), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH6A1(6), ALDH7A1(2), ALDH9A1(2), AOX1(18), AUH(4), BCAT1(7), BCAT2(3), BCKDHA(6), BCKDHB(3), DBT(5), DLD(5), ECHS1(3), EHHADH(11), HADH(1), HADHA(5), HADHB(4), HIBADH(5), HIBCH(6), HMGCL(2), HMGCS1(6), HMGCS2(9), HSD17B10(4), HSD17B4(13), IVD(2), MCCC1(9), MCCC2(5), MCEE(1), MUT(10), OXCT1(10), OXCT2(2), PCCA(6), PCCB(9)	16097432	251	69	247	70	63	100	58	2	28	0	0.11	1.00	1.00
369	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(4), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(6), CDS1(5), CHAT(5), CHKA(9), CHKB(6), CHPT1(1), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKI(20), DGKQ(2), DGKZ(10), ESCO1(16), ESCO2(8), ETNK1(10), ETNK2(3), GNPAT(11), GPAM(9), GPD1(3), GPD1L(4), GPD2(3), LCAT(4), LYPLA1(1), LYPLA2(7), NAT6(1), PCYT1A(4), PCYT1B(4), PEMT(1), PHOSPHO1(1), PISD(2), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLD1(14), PLD2(10), PNPLA3(7), PPAP2A(6), PPAP2B(3), PPAP2C(1), PTDSS1(5), PTDSS2(2), SH3GLB1(7)	24598128	348	69	343	126	108	124	69	3	43	1	0.70	1.00	1.00
370	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1C1(6), AKR1C2(3), AKR1C3(2), AKR1C4(6), ALDH1A3(8), ALDH3A1(7), ALDH3B2(7), CYP1A1(12), CYP1A2(11), CYP1B1(2), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2E1(2), CYP2F1(4), CYP2S1(8), CYP3A4(10), CYP3A43(4), CYP3A5(6), CYP3A7(7), DHDH(4), EPHX1(2), GSTA1(2), GSTA2(6), GSTA3(5), GSTA4(3), GSTA5(4), GSTK1(6), GSTM1(2), GSTM2(3), GSTM3(5), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTT1(1), GSTT2(1), GSTZ1(5), MGST1(4), MGST3(2), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2A1(11), UGT2A3(5), UGT2B10(18), UGT2B11(18), UGT2B15(9), UGT2B17(7), UGT2B28(21), UGT2B4(11), UGT2B7(5)	21911544	394	69	381	95	104	168	74	4	44	0	0.0012	1.00	1.00
371	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(6), ACTR3(1), ARHGAP1(2), ARHGAP4(11), ARHGAP5(21), ARHGAP6(18), ARHGEF1(12), ARHGEF11(20), ARHGEF5(13), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), BAIAP2(5), CFL1(1), DIAPH1(13), GSN(5), LIMK1(8), MYL2(2), MYLK(14), OPHN1(15), PFN1(1), PIP5K1A(8), PIP5K1B(5), PPP1R12B(20), ROCK1(22), SRC(3), TLN1(23), VCL(11)	17494664	274	69	269	93	100	100	48	0	24	2	0.54	1.00	1.00
372	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(2), ABP1(5), ACAT1(6), ACAT2(4), ACMSD(8), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), AOC2(7), AOC3(10), AOX1(18), ASMT(5), CAT(4), CYP19A1(13), CYP1A1(12), CYP1A2(11), CYP2A13(8), CYP2A6(11), CYP2A7(5), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2D6(2), CYP2E1(2), CYP2F1(4), CYP2J2(5), CYP3A4(10), CYP3A5(6), CYP3A7(7), CYP4B1(4), CYP4F8(7), CYP51A1(4), DDC(9), ECHS1(3), EHHADH(11), GCDH(6), HAAO(2), HADHA(5), KMO(11), KYNU(7), MAOA(12), MAOB(7), SDS(1), TDO2(3), TPH1(9), WARS(6), WARS2(3)	20500176	362	69	356	123	99	144	73	4	39	3	0.43	1.00	1.00
373	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(3), CASP10(8), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CFLAR(6), DAXX(10), DFFB(4), FADD(1), FAF1(10), JUN(1), LMNA(8), LMNB1(5), LMNB2(4), MAP2K4(9), MAP3K1(30), MAP3K7(9), MAPK8(10), PAK1(3), PAK2(3), PRKDC(54), PTPN13(30), RB1(26), RIPK2(6), SPTAN1(31)	16018320	307	68	298	84	76	103	58	4	62	4	0.29	1.00	1.00
374	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(33), ACACB(29), ACAT1(6), ACAT2(4), ACOT12(11), ACSS1(5), ACSS2(8), ACYP1(2), AKR1B1(1), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), DLAT(3), DLD(5), GRHPR(3), LDHA(8), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(4), LDHD(2), MDH1(4), MDH2(4), ME1(12), ME2(8), ME3(9), PC(12), PCK1(9), PCK2(7), PDHA1(7), PDHA2(10), PDHB(3), PKLR(7), PKM2(5)	17345616	265	68	256	92	85	97	43	5	34	1	0.52	1.00	1.00
375	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(8), AADAC(6), ABAT(9), ACADS(4), ACAT1(6), ACAT2(4), ACSM1(11), AKR1B10(4), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH5A1(7), ALDH7A1(2), ALDH9A1(2), BDH1(3), BDH2(4), DDHD1(10), ECHS1(3), EHHADH(11), GAD1(6), GAD2(12), HADH(1), HADHA(5), HMGCL(2), HMGCS1(6), HMGCS2(9), HSD17B10(4), HSD17B4(13), HSD3B7(5), ILVBL(8), L2HGDH(5), OXCT1(10), OXCT2(2), PDHA1(7), PDHA2(10), PDHB(3), PLA1A(6), PPME1(3), PRDX6(4), RDH11(1), RDH12(5), RDH13(4), RDH14(2)	15204136	254	68	244	77	79	90	50	6	28	1	0.13	1.00	1.00
376	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(5), ACTN1(9), ACTN2(16), ACTN3(10), BCAR1(8), BCR(6), CAPN1(5), CAPNS1(2), CAPNS2(3), CAV1(2), CRKL(6), CSK(1), FYN(7), GRB2(3), HRAS(1), ITGA1(17), ITGB1(8), JUN(1), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MAPK8(10), PPP1R12B(20), PTK2(12), PXN(6), RAF1(8), RAP1A(4), ROCK1(22), SHC1(7), SOS1(13), SRC(3), TLN1(23), VCL(11), ZYX(11)	17773416	272	68	264	77	102	87	50	0	32	1	0.032	1.00	1.00
377	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(8), AGTR1(4), ATF2(8), CALM1(2), CALM2(4), EGFR(12), ELK1(3), GNAQ(3), GRB2(3), HRAS(1), JUN(1), MAP2K1(2), MAP2K2(5), MAP2K4(9), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8(10), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), PAK1(3), PRKCA(10), PTK2(12), PTK2B(16), RAC1(1), RAF1(8), SHC1(7), SOS1(13), SRC(3), SYT1(4)	12843672	209	67	202	66	60	76	41	0	31	1	0.32	1.00	1.00
378	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), AKR1B10(4), B4GALT1(2), B4GALT2(5), G6PC(5), G6PC2(11), GAA(4), GALE(1), GALK1(1), GALK2(3), GALT(3), GANC(15), GCK(3), GLA(9), GLB1(6), HK1(11), HK2(9), HK3(10), HSD3B7(5), LALBA(2), LCT(32), MGAM(51), PFKL(8), PFKM(9), PFKP(8), PGM1(7), PGM3(4), RDH11(1), RDH12(5), RDH13(4), RDH14(2), UGP2(6)	14546440	247	67	243	91	83	89	47	3	25	0	0.58	1.00	1.00
379	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(8), CALM1(2), CALM2(4), CRKL(6), GNAQ(3), GRB2(3), HRAS(1), JUN(1), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP3K1(30), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(10), PAK1(3), PLCG1(12), PRKCA(10), PTK2B(16), RAC1(1), RAF1(8), SHC1(7), SOS1(13), SRC(3), SYT1(4)	10623328	177	67	170	58	53	64	35	0	24	1	0.46	1.00	1.00
380	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(56), CDH1(14), CREBBP(32), EP300(32), MAP2K1(2), MAP3K7(9), MAPK3(3), SKIL(7), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6)	9649432	182	67	173	49	48	62	36	2	30	4	0.20	1.00	1.00
381	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1A1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH3B2(7), ALDH9A1(2), ALDOA(5), ALDOB(9), ALDOC(3), BPGM(1), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), GAPDH(3), GCK(3), GPI(7), HK1(11), HK2(9), HK3(10), LDHA(8), LDHB(3), LDHC(4), PDHA1(7), PDHA2(10), PDHB(3), PFKM(9), PFKP(8), PGAM1(3), PGK1(7), PGM1(7), PGM3(4), PKLR(7), PKM2(5), TPI1(2)	18256768	279	66	277	92	87	103	51	2	36	0	0.23	1.00	1.00
382	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1A1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH3B2(7), ALDH9A1(2), ALDOA(5), ALDOB(9), ALDOC(3), BPGM(1), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), GAPDH(3), GCK(3), GPI(7), HK1(11), HK2(9), HK3(10), LDHA(8), LDHB(3), LDHC(4), PDHA1(7), PDHA2(10), PDHB(3), PFKM(9), PFKP(8), PGAM1(3), PGK1(7), PGM1(7), PGM3(4), PKLR(7), PKM2(5), TPI1(2)	18256768	279	66	277	92	87	103	51	2	36	0	0.23	1.00	1.00
383	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12(8), ALOX12B(10), ALOX15(9), ALOX15B(6), ALOX5(10), CBR1(4), CBR3(2), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2E1(2), CYP2J2(5), CYP2U1(2), CYP4A11(7), CYP4A22(7), CYP4F2(12), CYP4F3(8), EPHX2(7), GGT1(5), GPX2(1), GPX3(2), GPX5(6), GPX6(7), GPX7(1), LTA4H(4), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PTGDS(5), PTGES(2), PTGES2(3), PTGIS(7), PTGS1(6), PTGS2(9), TBXAS1(7)	14741864	248	66	240	73	88	90	40	5	25	0	0.069	1.00	1.00
384	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(9), ACACA(33), ACACB(29), ACADM(9), ACAT1(6), ACAT2(4), ACSS1(5), ACSS2(8), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH6A1(6), ALDH7A1(2), ALDH9A1(2), ECHS1(3), EHHADH(11), HADHA(5), HIBCH(6), LDHA(8), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(4), MCEE(1), MLYCD(3), MUT(10), PCCA(6), PCCB(9), SUCLA2(5), SUCLG1(5), SUCLG2(10)	14802128	239	66	233	65	62	87	53	5	31	1	0.096	1.00	1.00
385	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	48	ACHE(4), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPS(8), CDS1(5), CHAT(5), CHKA(9), CHKB(6), CLC(1), CPT1B(6), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKQ(2), DGKZ(10), ETNK1(10), GNPAT(11), GPD1(3), GPD2(3), LCAT(4), LGALS13(1), LYPLA1(1), LYPLA2(7), PAFAH1B1(2), PAFAH2(2), PCYT1A(4), PCYT1B(4), PEMT(1), PISD(2), PLA2G2E(5), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCB2(8), PLCG1(12), PLCG2(29), PPAP2A(6), PPAP2B(3), PPAP2C(1)	18749792	293	65	287	105	93	104	63	3	28	2	0.60	1.00	1.00
386	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(5), ALDOB(9), ALDOC(3), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), GAPDH(3), GAPDHS(10), GCK(3), GOT1(9), GOT2(3), GPI(7), HK1(11), HK2(9), HK3(10), LDHA(8), LDHAL6B(2), LDHB(3), LDHC(4), MDH1(4), MDH2(4), PC(12), PCK1(9), PDHA1(7), PDHA2(10), PDHB(3), PDHX(11), PFKL(8), PFKM(9), PFKP(8), PGAM1(3), PGAM2(1), PGK1(7), PGK2(6), PKLR(7), PKM2(5), TNFAIP1(3), TPI1(2)	15965248	249	65	245	83	87	88	44	2	28	0	0.25	1.00	1.00
387	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(5), ACAA2(3), ACADL(8), ACADM(9), ACADS(4), ACADSB(6), ACADVL(9), ACAT1(6), ACAT2(4), ACOX1(7), ACOX3(8), ACSL1(14), ACSL3(7), ACSL4(21), ACSL5(9), ACSL6(12), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), CPT1A(9), CPT1B(6), CPT1C(15), CPT2(4), CYP4A11(7), CYP4A22(7), ECHS1(3), EHHADH(11), GCDH(6), HADH(1), HADHA(5), HADHB(4), HSD17B10(4), HSD17B4(13)	18252552	298	65	292	80	86	107	66	2	37	0	0.019	1.00	1.00
388	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(2), C1GALT1(2), C1GALT1C1(6), GALNT1(10), GALNT10(8), GALNT11(12), GALNT12(6), GALNT13(18), GALNT14(6), GALNT2(9), GALNT3(7), GALNT4(8), GALNT5(7), GALNT6(1), GALNT7(13), GALNT8(11), GALNT9(8), GALNTL1(8), GALNTL2(17), GALNTL4(6), GALNTL5(11), GCNT1(5), GCNT3(5), GCNT4(1), OGT(17), ST3GAL1(2), ST3GAL2(6), ST6GALNAC1(4), WBSCR17(16)	12119016	233	65	226	80	62	86	48	1	35	1	0.73	1.00	1.00
389	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(4), ALPL(5), ALPP(4), ALPPL2(3), ASCC3(31), ATP13A2(5), DDX18(12), DDX19A(4), DDX23(9), DDX4(15), DDX41(3), DDX47(5), DDX50(10), DDX51(8), DDX52(4), DDX54(8), DDX55(7), DDX56(5), DHFR(4), DHX58(6), ENTPD7(8), EP400(42), ERCC2(1), ERCC3(11), FPGS(5), GCH1(1), GGH(2), IFIH1(5), MOV10L1(19), NUDT5(2), NUDT8(1), PTS(1), RAD54B(14), RAD54L(5), RUVBL2(4), SETX(33), SKIV2L2(17), SMARCA2(24), SMARCA5(19), SPR(1)	23647048	367	65	352	98	127	112	82	4	36	6	0.022	1.00	1.00
390	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(5), AGMAT(3), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH4A1(4), ALDH9A1(2), AMD1(3), AOC2(7), AOC3(10), ARG1(5), ARG2(3), ASL(2), CKM(3), CKMT1A(1), CKMT2(4), CPS1(22), DAO(8), GAMT(3), GATM(5), GLUD1(3), GOT1(9), GOT2(3), MAOA(12), MAOB(7), NOS1(18), NOS3(11), OAT(7), ODC1(2), OTC(7), P4HA1(6), P4HA2(12), P4HA3(3), P4HB(6), PYCR1(3), RARS(13), SMS(8)	16583016	268	64	263	93	88	95	50	6	27	2	0.42	1.00	1.00
391	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(5), AGXT(4), AGXT2(12), ALAS1(8), ALAS2(11), AMT(2), AOC2(7), AOC3(10), ATP6V0C(1), BHMT(2), CBS(11), CHDH(2), CHKA(9), CHKB(6), CPT1B(6), CTH(6), DAO(8), DLD(5), DMGDH(4), GAMT(3), GARS(8), GATM(5), GLDC(16), MAOA(12), MAOB(7), PEMT(1), PISD(2), PLCB2(8), PLCG1(12), PLCG2(29), PSPH(1), SARDH(9), SARS(4), SHMT1(5), SHMT2(5), TARS(9)	15876216	255	64	246	89	78	100	50	0	27	0	0.50	1.00	1.00
392	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(9), ADC(8), ALDH4A1(4), ALDH5A1(7), CAD(25), CPS1(22), EARS2(5), EPRS(15), GAD1(6), GAD2(12), GCLC(8), GCLM(2), GFPT1(9), GFPT2(12), GLS(11), GLS2(7), GLUD1(3), GLUD2(9), GLUL(7), GMPS(14), GNPNAT1(2), GOT1(9), GOT2(3), GPT(2), GPT2(5), GSR(6), GSS(5), NADSYN1(6), NAGK(2), PPAT(9), QARS(7)	14840320	251	63	245	79	80	79	48	4	38	2	0.26	1.00	1.00
393	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(8), AARS2(7), ABAT(9), ACY3(3), ADSL(8), ADSS(6), ADSSL1(5), AGXT(4), AGXT2(12), ASL(2), ASNS(9), ASPA(5), ASS1(2), CAD(25), CRAT(3), DARS(7), DARS2(10), DDO(7), DLAT(3), DLD(5), GAD1(6), GAD2(12), GOT1(9), GOT2(3), GPT(2), GPT2(5), NARS(11), NARS2(10), PC(12), PDHA1(7), PDHA2(10), PDHB(3)	14323240	230	63	224	79	58	95	41	5	31	0	0.49	1.00	1.00
394	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	AGA(7), ARSB(5), FUCA1(3), FUCA2(4), GALNS(4), GBA(4), GLB1(6), GNS(5), GUSB(5), HEXA(3), HEXB(5), HGSNAT(9), HPSE(6), HPSE2(11), HYAL1(2), HYAL2(4), IDS(8), IDUA(7), LCT(32), MAN2B1(14), MAN2B2(5), MAN2C1(7), MANBA(12), NAGLU(3), NEU2(4), NEU3(3), SPAM1(15)	12441168	193	63	192	78	50	82	36	4	21	0	0.87	1.00	1.00
395	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(2), CALM2(4), CAMK1(2), CAMK1G(5), ELK1(3), FPR1(2), GNA15(2), GNB1(2), GNGT1(1), HRAS(1), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K6(10), MAP3K1(30), MAPK1(2), MAPK14(4), MAPK3(3), NCF1(3), NCF2(8), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NFKB1(10), NFKBIA(3), PAK1(3), PIK3C2G(16), PLCB1(5), PPP3CA(4), PPP3CB(5), PPP3CC(6), RAC1(1), RAF1(8), RELA(6), SYT1(4)	14343328	211	62	205	68	64	73	40	2	31	1	0.37	1.00	1.00
396	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), AKR1B10(4), ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), FPGT(6), FUK(8), GMDS(4), GMPPA(6), GMPPB(2), HK1(11), HK2(9), HK3(10), HSD3B7(5), KHK(2), LHPP(2), MPI(5), MTMR1(16), MTMR2(5), MTMR6(10), PFKFB1(8), PFKFB2(4), PFKFB3(4), PFKFB4(4), PFKL(8), PFKM(9), PFKP(8), PGM2(8), PHPT1(1), PMM2(6), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SORD(5), TPI1(2), TSTA3(4)	14291248	209	62	204	79	78	62	36	3	30	0	0.60	1.00	1.00
397	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(5), AGXT(4), AGXT2(12), AKR1B10(4), ALAS1(8), ALAS2(11), AMT(2), AOC2(7), AOC3(10), BHMT(2), CBS(11), CHDH(2), CHKA(9), CHKB(6), CTH(6), DAO(8), DLD(5), DMGDH(4), GAMT(3), GARS(8), GATM(5), GLDC(16), GNMT(3), HSD3B7(5), MAOA(12), MAOB(7), PEMT(1), PHGDH(5), PIPOX(4), PISD(2), PSAT1(5), PSPH(1), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SARDH(9), SARS(4), SARS2(6), SDS(1), SHMT1(5), SHMT2(5), TARS(9), TARS2(10)	16168360	254	62	247	98	79	102	46	1	26	0	0.76	1.00	1.00
398	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(5), ACY3(3), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH3B2(7), ALDH7A1(2), ALDH9A1(2), AMDHD1(13), AOC2(7), AOC3(10), ASPA(5), CARM1(5), CNDP1(4), DDC(9), FTCD(8), HAL(6), HARS(5), HARS2(7), HDC(9), HEMK1(3), HNMT(4), LCMT1(2), LCMT2(9), MAOA(12), MAOB(7), METTL2B(4), METTL6(5), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), PRPS1(3), PRPS2(7), UROC1(9), WBSCR22(5)	14774600	244	62	236	80	71	92	45	4	32	0	0.24	1.00	1.00
399	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(6), ALG10B(6), ALG11(6), ALG12(7), ALG13(24), ALG14(2), ALG2(2), ALG3(1), ALG5(2), ALG6(5), ALG8(10), ALG9(4), B4GALT1(2), B4GALT2(5), B4GALT3(10), DAD1(2), DDOST(3), DHDDS(4), DOLPP1(2), DPAGT1(3), DPM1(2), FUT8(13), GANAB(10), MAN1A1(13), MAN1A2(7), MAN1B1(5), MAN1C1(6), MAN2A1(20), MGAT1(4), MGAT2(4), MGAT3(4), MGAT4A(5), MGAT4B(6), MGAT5(11), MGAT5B(10), RFT1(6), RPN1(3), RPN2(5), ST6GAL1(7), STT3B(5)	15563488	254	62	239	65	82	85	55	1	30	1	0.025	1.00	1.00
400	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(8), ALOX15(9), ALOX5(10), CBR1(4), CBR3(2), CYP4F2(12), CYP4F3(8), EPX(15), GGT1(5), LPO(6), LTA4H(4), MPO(10), PLA2G2E(5), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PRDX2(4), PRDX5(1), PRDX6(4), PTGDS(5), PTGES2(3), PTGIS(7), PTGS1(6), PTGS2(9), TBXAS1(7), TPO(15)	10556864	191	62	183	60	77	65	28	5	16	0	0.15	1.00	1.00
401	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(4), ATF1(6), CDC42(4), CREB1(6), CREB5(5), DUSP1(2), DUSP10(5), EEF2K(11), EIF4E(2), ELK1(3), IL1R1(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP3K10(7), MAP3K4(21), MAP3K5(25), MAP3K7(9), MAPK1(2), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPKAPK2(6), MAPKAPK5(5), MKNK1(3), MKNK2(3), MYEF2(6), NFKB1(10), NR2C2(7), SRF(3), TRAF6(7)	12539128	207	61	204	59	70	75	40	1	21	0	0.13	1.00	1.00
402	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(17), BAD(2), BAX(3), BCL2L1(4), BCL2L2(2), BOK(2), CASP1(8), CASP10(8), CASP2(6), CASP3(4), CASP4(5), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CD40(4), CD40LG(6), CRADD(3), CYCS(2), DAXX(10), DFFB(4), FADD(1), FAS(9), FASLG(7), IKBKE(4), LTA(3), MCL1(1), NFKB1(10), NFKBIA(3), NGFR(3), NR3C1(18), NTRK1(13), PTPN13(30), RIPK1(9), TFG(4), TNFRSF1A(4), TNFRSF1B(2), TRAF1(5), TRAF2(3), TRAF3(5), TRAF6(7)	16035184	266	60	260	78	59	107	51	2	47	0	0.26	1.00	1.00
403	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT1(2), B4GALT2(5), FBP2(1), G6PC(5), GAA(4), GALE(1), GALK1(1), GALK2(3), GALT(3), GANAB(10), GCK(3), GLA(9), GLB1(6), HK1(11), HK2(9), HK3(10), LALBA(2), LCT(32), MGAM(51), PFKM(9), PFKP(8), PGM1(7), PGM3(4)	12245248	197	60	194	83	64	73	37	2	21	0	0.90	1.00	1.00
404	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(4), ARG1(5), ARG2(3), ASL(2), ASS1(2), CKM(3), CKMT1A(1), CKMT2(4), CPS1(22), DAO(8), EPRS(15), GAMT(3), GATM(5), GLUD1(3), GLUD2(9), GOT1(9), GOT2(3), LAP3(10), NOS1(18), NOS3(11), OAT(7), OTC(7), P4HA1(6), P4HA2(12), P4HA3(3), PARS2(4), PRODH(12), PYCR1(3), PYCR2(2), PYCRL(1), RARS(13), RARS2(8)	13602800	218	60	214	79	71	81	39	5	20	2	0.65	1.00	1.00
405	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(3), GTF2A1L(3), GTF2B(5), GTF2E1(3), GTF2E2(2), GTF2F1(7), GTF2F2(1), GTF2H1(9), GTF2H3(3), GTF2H4(2), GTF2I(4), GTF2IRD1(7), STON1(1), TAF1(57), TAF10(1), TAF1L(40), TAF2(19), TAF4(10), TAF4B(4), TAF5(8), TAF5L(5), TAF6(9), TAF6L(5), TAF7(4), TAF7L(10), TAF9(4), TAF9B(12), TBPL1(5), TBPL2(5)	13245680	248	60	241	59	83	95	43	3	23	1	0.036	1.00	1.00
406	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(12), ADRBK2(15), ARRB2(4), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CLCA1(15), CLCA2(10), CLCA4(15), CNGA3(13), CNGA4(10), CNGB1(13), GNAL(6), GUCA1A(5), GUCA1B(3), GUCA1C(5), PDC(1), PDE1C(12), PRKACA(6), PRKACB(3), PRKACG(9), PRKG1(11), PRKG2(11), PRKX(2)	11548368	216	60	212	73	67	82	34	2	31	0	0.37	1.00	1.00
407	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(8), CREBBP(32), DUSP1(2), EP300(32), IKBKB(13), IL1B(2), IL8(3), MAP2K3(7), MAP2K6(10), MAP3K14(6), MAP3K7(9), MAPK11(3), MAPK14(4), MYD88(3), NFKB1(10), NFKBIA(3), NR3C1(18), RELA(6), TGFBR1(5), TGFBR2(6), TLR2(16)	11060552	198	60	191	51	57	64	43	2	30	2	0.082	1.00	1.00
408	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(8), BCR(6), BLNK(4), ELK1(3), FOS(3), GRB2(3), HRAS(1), JUN(1), LYN(9), MAP2K1(2), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8IP3(9), PAPPA(27), RAC1(1), RPS6KA1(1), RPS6KA3(19), SHC1(7), SOS1(13), SYK(4), VAV1(12), VAV2(7), VAV3(14)	11987328	189	60	183	58	52	71	38	1	26	1	0.24	1.00	1.00
409	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), DAG1(6), ITPKA(1), ITPKB(12), ITPR1(36), ITPR2(35), ITPR3(21), NFAT5(16), PDE6A(10), PDE6B(5), PDE6C(13), PDE6D(2), PDE6G(1), PDE6H(1), SLC6A13(9), TF(14)	13619912	204	60	201	71	59	86	25	1	32	1	0.32	1.00	1.00
410	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(9), ABP1(5), ACADL(8), ACADM(9), ACADSB(6), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), AOC2(7), AOC3(10), CNDP1(4), DPYD(20), DPYS(6), ECHS1(3), EHHADH(11), GAD1(6), GAD2(12), HADHA(5), MLYCD(3), SDS(1), SMS(8), UPB1(10)	10674664	193	59	190	71	50	67	49	3	24	0	0.56	1.00	1.00
411	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(14), F11(15), F12(2), F13B(17), F2(8), F5(48), F7(2), F8(45), F9(14), FGA(26), FGB(7), FGG(10), LPA(16), PLAT(6), PLAU(6), PLG(14), SERPINB2(9), SERPINE1(5), SERPINF2(4), VWF(25)	13119944	293	59	276	76	69	136	53	0	35	0	0.035	1.00	1.00
412	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(17), BID(2), BIRC2(10), BIRC3(5), CASP10(8), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CFLAR(6), CHUK(8), CYCS(2), DFFB(4), FADD(1), GAS2(7), LMNA(8), MAP3K14(6), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(9), SPTAN1(31), TNFRSF10A(2), TNFRSF10B(5), TNFRSF25(3), TNFSF10(1), TNFSF12(4), TRAF2(3)	12433480	200	59	194	51	51	80	24	3	42	0	0.088	1.00	1.00
413	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(2), EGFR(12), ELK1(3), GNAS(24), GNB1(2), GNGT1(1), GRB2(3), HRAS(1), IGF1R(13), ITGB1(8), KLK2(2), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MKNK1(3), MKNK2(3), MYC(8), NGFR(3), PDGFRA(24), PPP2CA(6), PTPRR(17), RAF1(8), RPS6KA1(1), RPS6KA5(11), SHC1(7), SOS1(13), SRC(3), STAT3(10)	12313448	200	59	191	50	55	77	43	1	23	1	0.027	1.00	1.00
414	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(9), ACACA(33), ACADL(8), ACADM(9), ACADSB(6), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH6A1(6), ALDH9A1(2), ECHS1(3), EHHADH(11), HADHA(5), LDHA(8), LDHB(3), LDHC(4), MCEE(1), MLYCD(3), MUT(10), PCCA(6), PCCB(9), SDS(1), SUCLA2(5), SUCLG1(5), SUCLG2(10)	12363544	215	59	212	59	49	75	54	4	33	0	0.15	1.00	1.00
415	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(5), ACAA2(3), ACADL(8), ACADM(9), ACADS(4), ACADSB(6), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH6A1(6), ALDH9A1(2), AOX1(18), BCAT1(7), BCKDHA(6), BCKDHB(3), ECHS1(3), EHHADH(11), HADHA(5), HADHB(4), HIBADH(5), HMGCL(2), IVD(2), MCCC1(9), MCCC2(5), MCEE(1), MUT(10), OXCT1(10), PCCA(6), PCCB(9), SDS(1)	13449040	218	59	215	70	54	83	51	2	28	0	0.37	1.00	1.00
416	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(54), BMPR1B(6), CCND2(9), CDK4(3), CDKN1B(7), DAZL(6), DMC1(5), EGR1(6), ESR2(5), FSHR(17), GJA4(1), INHA(1), LHCGR(17), MLH1(7), MSH5(10), NCOR1(23), NR5A1(3), NRIP1(17), PGR(13), PRLR(5), PTGER2(3), SMPD1(11), VDR(8), ZP2(12)	12651224	249	58	239	65	51	99	40	6	49	4	0.14	1.00	1.00
417	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(33), ACAT1(6), ACAT2(4), ACYP1(2), AKR1B1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), DLAT(3), DLD(5), GRHPR(3), LDHA(8), LDHB(3), LDHC(4), LDHD(2), MDH1(4), MDH2(4), ME1(12), ME2(8), ME3(9), PC(12), PCK1(9), PDHA1(7), PDHA2(10), PDHB(3), PKLR(7), PKM2(5)	13703736	214	58	210	69	65	78	38	4	29	0	0.35	1.00	1.00
418	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(7), CDK7(7), ERCC3(11), GTF2B(5), GTF2E1(3), GTF2E2(2), GTF2F2(1), GTF2H1(9), GTF2H4(2), ILK(5), POLR1A(16), POLR1B(16), POLR2A(21), POLR2B(22), POLR2C(5), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(2), POLR2K(2), POLR3B(14), POLR3D(3), POLR3E(5), POLR3H(5), TAF5(8), TAF6(9), TAF7(4), TAF9(4), TBP(3)	12891536	197	58	195	59	73	66	29	3	25	1	0.28	1.00	1.00
419	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(56), ASAH1(7), CAMP(1), CASP3(4), CERK(6), CREB1(6), CREB5(5), CXCL2(2), DAG1(6), EPHB2(12), FOS(3), GNAQ(3), ITPKA(1), ITPKB(12), JUN(1), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(9), MAPK8(10), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(5)	10479488	179	58	175	60	48	68	20	1	38	4	0.39	1.00	1.00
420	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(21), CALM1(2), CALM2(4), CREB1(6), ELK1(3), FOS(3), GNAI1(5), GNAQ(3), GNAS(24), GNB1(2), GNGT1(1), HRAS(1), JUN(1), MAP2K1(2), MAPK3(3), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), RAF1(8), RPS6KA3(19), SYT1(4)	12508872	218	57	209	74	80	66	42	1	28	1	0.39	1.00	1.00
421	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(11), ACO1(17), ACO2(7), CLYBL(9), CS(6), DLD(5), DLST(9), FH(8), IDH1(4), IDH2(5), IDH3A(3), IDH3B(3), IDH3G(10), MDH1(4), MDH2(4), OGDH(13), OGDHL(19), PC(12), PCK1(9), PCK2(7), SDHA(15), SDHB(2), SDHC(4), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(10)	11283256	209	57	204	70	82	63	40	4	20	0	0.22	1.00	1.00
422	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(2), CALM2(4), CHUK(8), EGR2(6), EGR3(7), GNAQ(3), MAP3K1(30), MYC(8), NFATC1(10), NFATC2(13), NFKB1(10), NFKBIA(3), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RELA(6), SYT1(4), VIP(3), VIPR2(4)	10055408	175	57	170	56	49	66	32	2	24	2	0.30	1.00	1.00
423	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(8), ABAT(9), ADSL(8), ADSS(6), AGXT(4), AGXT2(12), ASL(2), ASNS(9), ASPA(5), CAD(25), CRAT(3), DARS(7), DDO(7), GAD1(6), GAD2(12), GOT1(9), GOT2(3), GPT(2), GPT2(5), NARS(11), PC(12)	9881808	165	56	161	53	44	64	29	4	24	0	0.30	1.00	1.00
424	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(9), ALDH4A1(4), ALDH5A1(7), CAD(25), CPS1(22), EPRS(15), GAD1(6), GAD2(12), GCLC(8), GCLM(2), GFPT1(9), GLS(11), GLS2(7), GLUD1(3), GLUL(7), GMPS(14), GOT1(9), GOT2(3), GPT(2), GPT2(5), GSS(5), NADSYN1(6), PPAT(9), QARS(7)	12433976	207	56	201	63	57	68	44	4	32	2	0.31	1.00	1.00
425	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(5), ACAA2(3), ACAD8(5), ACAD9(8), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1B10(4), AKR1C4(6), AKR1D1(8), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), BAAT(7), CEL(5), CYP27A1(9), CYP7A1(11), HADHB(4), HSD3B7(5), LIPA(8), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SLC27A5(3), SOAT1(9), SOAT2(5), SRD5A1(6), SRD5A2(6)	11874736	200	56	196	63	67	70	35	4	23	1	0.17	1.00	1.00
426	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	34	ARSA(2), ARSD(6), ARSE(10), ASAH1(7), B4GALT6(6), CERK(6), DEGS1(5), DEGS2(4), ENPP7(3), GAL3ST1(7), GALC(8), GBA(4), GLA(9), GLB1(6), LCT(32), NEU2(4), NEU3(3), PPAP2A(6), PPAP2B(3), PPAP2C(1), SGMS1(5), SGMS2(5), SGPP1(2), SGPP2(4), SMPD1(11), SMPD2(7), SMPD3(7), SMPD4(8), SPHK1(2), SPHK2(2), SPTLC1(6), SPTLC2(5), UGCG(4), UGT8(14)	12565416	214	56	209	64	56	98	32	3	25	0	0.068	1.00	1.00
427	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(8), IFNA1(2), IFNB1(3), IKBKB(13), IL1B(2), IL1R1(5), IL1RAP(8), IL6(5), IRAK1(4), IRAK2(9), IRAK3(10), JUN(1), MAP2K3(7), MAP2K6(10), MAP3K1(30), MAP3K14(6), MAP3K7(9), MAPK14(4), MAPK8(10), MYD88(3), NFKB1(10), NFKBIA(3), RELA(6), TGFB1(2), TGFB2(5), TGFB3(9), TOLLIP(1), TRAF6(7)	11143136	192	56	188	44	42	80	37	1	30	2	0.038	1.00	1.00
428	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(6), BAD(2), BRAF(10), CREB1(6), CREB5(5), DUSP6(2), DUSP9(1), EEF2K(11), EIF4E(2), GRB2(3), MAP2K1(2), MAP2K2(5), MAP3K8(10), MAPK1(2), MAPK3(3), MKNK1(3), MKNK2(3), MOS(6), NFKB1(10), RAP1A(4), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), SHC1(7), SOS1(13), SOS2(17), TRAF3(5)	11123296	172	56	168	59	51	63	37	1	19	1	0.52	1.00	1.00
429	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(12), DLG4(11), EPHB2(12), F2(8), F2RL1(4), F2RL2(2), JUN(1), MAP2K5(3), MAPK1(2), MAPK7(14), MAPK8(10), MYEF2(6), PLD1(14), PLD2(10), PLD3(5), PTK2(12), RAF1(8), RASAL1(14), SRC(3), TEC(8), VAV1(12)	10331928	171	56	168	61	59	54	29	3	26	0	0.68	1.00	1.00
430	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(5), ALDH1A3(8), ALDH3A1(7), ALDH3B2(7), AOC2(7), AOC3(10), DDC(9), EPX(15), ESCO1(16), ESCO2(8), GOT1(9), GOT2(3), HPD(7), LPO(6), MAOA(12), MAOB(7), MPO(10), NAT6(1), PNPLA3(7), PRDX6(4), SH3GLB1(7), TAT(7), TPO(15)	12585504	187	55	179	62	59	67	34	3	24	0	0.42	1.00	1.00
431	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(9), ABP1(5), ACADM(9), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), AOC2(7), AOC3(10), CNDP1(4), DPYD(20), DPYS(6), ECHS1(3), EHHADH(11), GAD1(6), GAD2(12), HADHA(5), HIBCH(6), MLYCD(3), SMS(8), SRM(1), UPB1(10)	9876600	166	55	163	56	45	60	40	3	18	0	0.34	1.00	1.00
432	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	30	AADAT(6), AASDH(10), AASDHPPT(9), AASS(12), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), ATP6V0C(1), BBOX1(1), DLST(9), DOT1L(8), ECHS1(3), EHHADH(11), EHMT1(23), GCDH(6), HADHA(5), PLOD1(4), PLOD2(13), PLOD3(7), SDS(1), SHMT1(5), SHMT2(5), TMLHE(6)	12796304	205	55	200	70	65	70	43	5	21	1	0.28	1.00	1.00
433	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(4), AP2A1(7), AP2M1(8), ARF1(3), BAD(2), BTK(12), EEA1(17), GRASP(4), GSK3A(10), GSK3B(13), LYN(9), PDPK1(3), PFKL(8), PFKM(9), PFKP(8), PLCG1(12), PRKCE(10), PRKCZ(3), RAB5A(2), RAC1(1), RPS6KB1(5), VAV2(7)	9643976	157	55	152	55	62	53	25	0	17	0	0.40	1.00	1.00
434	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(6), CASP2(6), CHUK(8), CRADD(3), IKBKB(13), IKBKG(4), JUN(1), LTA(3), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP3K1(30), MAP3K14(6), MAP4K2(7), MAPK14(4), MAPK8(10), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(9), TANK(5), TNFRSF1A(4), TRAF2(3)	8864760	167	54	165	42	37	62	34	1	31	2	0.099	1.00	1.00
435	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(5), ALDOB(9), ALDOC(3), DERA(10), FBP1(2), FBP2(1), G6PD(6), GPI(7), H6PD(7), PFKL(8), PFKM(9), PFKP(8), PGD(3), PGLS(2), PGM1(7), PGM3(4), PRPS1(3), PRPS1L1(5), PRPS2(7), RBKS(1), RPE(5), RPIA(9), TALDO1(6), TKT(6), TKTL1(9), TKTL2(15)	8968920	157	53	150	50	63	48	23	1	22	0	0.12	1.00	1.00
436	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(4), ALOX15(9), ALOX5(10), CYP1A2(11), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2E1(2), CYP2J2(5), CYP3A4(10), CYP3A43(4), CYP3A5(6), CYP3A7(7), HSD3B7(5), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), RDH11(1), RDH12(5), RDH13(4), RDH14(2)	8987520	153	53	148	44	47	58	23	4	21	0	0.15	1.00	1.00
437	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(3), ALAS1(8), ALAS2(11), BLVRA(1), BLVRB(1), COX10(3), COX15(3), CP(15), CPOX(6), EARS2(5), EPRS(15), FECH(7), FTH1(2), FTMT(7), GUSB(5), HCCS(1), HMBS(8), HMOX1(4), HMOX2(3), MMAB(2), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2A1(11), UGT2A3(5), UGT2B10(18), UGT2B11(18), UGT2B15(9), UGT2B17(7), UGT2B28(21), UGT2B4(11), UGT2B7(5), UROD(3), UROS(3)	15821904	267	53	254	68	72	119	46	2	28	0	0.045	1.00	1.00
438	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(7), CS(6), DLAT(3), DLD(5), DLST(9), FH(8), IDH2(5), IDH3A(3), IDH3B(3), IDH3G(10), MDH1(4), MDH2(4), OGDH(13), PC(12), PDHA1(7), PDHA2(10), PDHB(3), PDHX(11), PDK1(2), PDK2(5), PDK3(12), PDK4(10), PDP2(4), SDHA(15), SDHB(2), SDHC(4), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(10)	10774112	200	53	197	65	71	69	35	2	23	0	0.27	1.00	1.00
439	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(8), CARS(9), DARS(7), EPRS(15), FARS2(2), GARS(8), HARS(5), IARS(8), KARS(5), LARS(19), LARS2(8), MARS(11), MARS2(4), NARS(11), QARS(7), RARS(13), SARS(4), TARS(9), WARS(6), WARS2(3), YARS(5)	11864816	167	52	164	61	46	72	32	1	16	0	0.89	1.00	1.00
440	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(8), ABAT(9), ACADS(4), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH5A1(7), ALDH9A1(2), ECHS1(3), EHHADH(11), GAD1(6), GAD2(12), HADHA(5), HMGCL(2), L2HGDH(5), OXCT1(10), PDHA1(7), PDHA2(10), PDHB(3), SDHB(2), SDS(1)	9593880	165	52	161	48	49	58	36	3	19	0	0.10	1.00	1.00
441	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(10), AZIN1(8), CBX3(4), CLOCK(9), CRY1(9), CRY2(3), DNAJA1(3), EIF4G2(7), ETV6(6), GFRA1(9), GSTM3(5), GSTP1(2), HERPUD1(2), HSPA8(8), IDI1(3), KLF9(3), MYF6(8), NCKAP1(8), NCOA4(7), NR1D2(2), PER1(10), PER2(13), PIGF(2), PPP1R3C(4), PPP2CB(4), PSMA4(2), SF3A3(8), SUMO3(3), TOB1(4), TUBB3(6), UGP2(6), VAPA(6), ZFR(10)	13586432	194	52	189	59	62	71	37	2	22	0	0.34	1.00	1.00
442	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(5), ACP2(1), ACP5(5), ACPP(5), ACPT(5), ALPI(4), ALPL(5), ALPP(4), ALPPL2(3), CYP19A1(13), CYP1A1(12), CYP1A2(11), CYP2A13(8), CYP2A6(11), CYP2A7(5), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2D6(2), CYP2E1(2), CYP2F1(4), CYP2J2(5), CYP3A4(10), CYP3A5(6), CYP3A7(7), CYP4B1(4), CYP4F8(7), CYP51A1(4), PON1(12)	10972512	197	52	193	72	60	77	37	1	20	2	0.58	1.00	1.00
443	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(5), CHIA(3), CHIT1(6), CMAS(7), CTBS(4), CYB5R1(3), CYB5R3(5), GFPT1(9), GFPT2(12), GNE(10), GNPDA1(2), GNPDA2(10), GNPNAT1(2), HEXA(3), HEXB(5), HK1(11), HK2(9), HK3(10), LHPP(2), MTMR1(16), MTMR2(5), MTMR6(10), NAGK(2), NANS(7), NPL(7), PGM3(4), PHPT1(1), RENBP(4), UAP1(6)	10875048	180	52	178	54	56	57	37	1	29	0	0.25	1.00	1.00
444	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(30), APOA1(3), APOA4(3), APOC1(3), APOC3(1), APOE(1), CETP(5), CYP7A1(11), DGAT1(3), HMGCR(12), LCAT(4), LDLR(6), LIPC(8), LPL(16), LRP1(51), SCARB1(7), SOAT1(9)	10160560	173	52	170	47	67	54	36	0	16	0	0.033	1.00	1.00
445	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(5), ACTN1(9), ACTN2(16), ACTN3(10), CAPN1(5), CAPNS1(2), CAPNS2(3), ITGA1(17), ITGB1(8), ITGB3(11), PTK2(12), PXN(6), RAC1(1), SPTAN1(31), SRC(3), TLN1(23)	10939776	162	52	159	61	67	47	23	1	24	0	0.65	1.00	1.00
446	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	29	AKR1C4(6), AKR1D1(8), ARSB(5), ARSD(6), ARSE(10), CYP11B1(8), CYP11B2(9), HSD11B1(6), HSD17B2(2), HSD17B3(6), HSD3B1(3), HSD3B2(6), SRD5A1(6), SRD5A2(6), STS(8), SULT1E1(9), SULT2A1(7), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2B15(9), UGT2B4(11)	9998864	177	51	170	55	46	84	27	2	18	0	0.25	1.00	1.00
447	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(20), GABBR1(12), GPRC5A(7), GPRC5B(6), GPRC5C(3), GPRC5D(4), GRM1(29), GRM2(9), GRM3(19), GRM4(12), GRM5(27), GRM7(20), GRM8(19)	7167944	187	51	179	65	61	69	31	3	21	2	0.16	1.00	1.00
448	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(14), ACE2(22), AGT(8), AGTR1(4), AGTR2(11), ANPEP(15), CMA1(2), CPA3(5), CTSA(11), CTSG(3), ENPEP(19), LNPEP(10), MAS1(3), MME(11), NLN(4), REN(4), THOP1(3)	7903264	149	51	144	51	34	62	34	2	16	1	0.51	1.00	1.00
449	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(9), BAIAP2(5), CASP1(8), CASP3(4), CASP7(4), CASP8(21), GAPDH(3), INS(3), INSR(18), ITCH(10), MAGI1(24), MAGI2(28), RERE(18), WWP1(19), WWP2(9)	8766800	183	51	177	55	56	59	36	1	30	1	0.34	1.00	1.00
450	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(16), AP2A1(7), AP2M1(8), BIN1(3), CALM1(2), CALM2(4), DNM1(4), EPN1(9), EPS15(11), NME1(2), PICALM(11), PPP3CA(4), PPP3CB(5), PPP3CC(6), SYNJ1(29), SYNJ2(11), SYT1(4)	8563192	136	51	132	51	47	44	26	0	19	0	0.60	1.00	1.00
451	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(21), CD3D(6), CD3E(2), CD3G(3), CD4(6), CREBBP(32), CSK(1), GNAS(24), GNB1(2), GNGT1(1), LCK(5), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PTPRC(17), ZAP70(9)	8165152	156	50	150	53	54	54	24	1	21	2	0.40	1.00	1.00
452	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(21), CD3D(6), CD3E(2), CD3G(3), CD4(6), CREBBP(32), CSK(1), GNAS(24), GNB1(2), GNGT1(1), LCK(5), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PTPRC(17), ZAP70(9)	8165152	156	50	150	53	54	54	24	1	21	2	0.40	1.00	1.00
453	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(5), ACY1(3), ADC(8), AGMAT(3), ALDH18A1(9), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), AMD1(3), AOC2(7), AOC3(10), ARG1(5), ARG2(3), ASL(2), ASS1(2), CPS1(22), GATM(5), MAOA(12), MAOB(7), NAGS(3), ODC1(2), OTC(7), SAT1(5), SAT2(1), SMS(8), SRM(1)	10964328	164	50	161	68	51	60	29	3	19	2	0.86	1.00	1.00
454	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	FAU(2), MRPS7(3), RPL10A(1), RPL10L(8), RPL11(3), RPL13(1), RPL13A(1), RPL14(8), RPL18(4), RPL18A(2), RPL19(4), RPL21(3), RPL22L1(5), RPL23A(5), RPL24(2), RPL27(1), RPL27A(3), RPL28(3), RPL29(2), RPL3(2), RPL34(1), RPL35A(2), RPL36AL(1), RPL37(3), RPL37A(1), RPL38(1), RPL39(4), RPL3L(3), RPL6(3), RPL7(1), RPL8(2), RPL9(2), RPS10(1), RPS11(1), RPS12(2), RPS13(1), RPS15A(1), RPS16(1), RPS18(3), RPS20(3), RPS21(3), RPS24(2), RPS25(2), RPS27(1), RPS28(1), RPS29(2), RPS3(3), RPS3A(1), RPS6(7), RPS7(5), RPS8(2), RPS9(1), RPSA(1)	8446384	131	50	122	39	36	49	27	3	16	0	0.66	1.00	1.00
455	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(5), CAPN1(5), CAPN2(11), CAPNS1(2), CAPNS2(3), CXCR3(5), EGF(20), EGFR(12), HRAS(1), ITGA1(17), ITGB1(8), MAPK1(2), MAPK3(3), MYL2(2), MYLK(14), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PTK2(12), PXN(6), TLN1(23)	12580544	178	50	175	55	65	53	35	1	23	1	0.13	1.00	1.00
456	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(17), ACO2(7), CS(6), DLD(5), DLST(9), FH(8), IDH1(4), IDH2(5), IDH3A(3), IDH3B(3), IDH3G(10), MDH1(4), MDH2(4), PC(12), PCK1(9), SDHA(15), SDHB(2), SUCLA2(5), SUCLG1(5), SUCLG2(10)	7806544	143	49	141	50	61	42	24	2	14	0	0.32	1.00	1.00
457	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(2), CALM2(4), DLG4(11), GRIN1(4), GRIN2A(25), GRIN2B(25), GRIN2C(6), GRIN2D(5), NOS1(18), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), SYT1(4)	9705728	156	49	153	75	54	51	33	1	16	1	0.96	1.00	1.00
458	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(5), ALDH1A3(8), ALDH3A1(7), ALDH3B2(7), AOC2(7), AOC3(10), DDC(9), EPX(15), GOT1(9), GOT2(3), HPD(7), LPO(6), MAOA(12), MAOB(7), MPO(10), PRDX2(4), PRDX5(1), PRDX6(4), TAT(7), TPO(15)	8222936	153	49	145	54	50	52	28	3	20	0	0.45	1.00	1.00
459	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(5), ACAA2(3), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1C4(6), AKR1D1(8), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), BAAT(7), CEL(5), CYP27A1(9), CYP7A1(11), HADHB(4), SOAT2(5), SRD5A1(6), SRD5A2(6)	8661152	165	48	161	48	54	57	32	3	19	0	0.089	1.00	1.00
460	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	21	ARSA(2), ARSB(5), ARSD(6), ARSE(10), ASAH1(7), GAL3ST1(7), GALC(8), GBA(4), GLA(9), GLB1(6), LCT(32), NEU2(4), NEU3(3), PPAP2A(6), PPAP2B(3), PPAP2C(1), SMPD1(11), SMPD2(7), SPTLC1(6), SPTLC2(5), UGCG(4)	8333792	146	48	143	47	37	71	24	1	13	0	0.29	1.00	1.00
461	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(6), CARM1(5), CBS(11), CTH(6), GGT1(5), HEMK1(3), LCMT1(2), LCMT2(9), MARS(11), MARS2(4), MAT1A(4), MAT2B(12), METTL2B(4), METTL6(5), PAPSS1(8), PAPSS2(7), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), SCLY(3), SEPHS1(12), SEPHS2(5), WBSCR22(5)	9219648	167	48	162	51	60	65	19	2	21	0	0.12	1.00	1.00
462	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	29	AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(6), AGPS(8), CHPT1(1), ENPP2(25), ENPP6(11), PAFAH1B1(2), PAFAH1B2(3), PAFAH2(2), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLD1(14), PLD2(10), PPAP2A(6), PPAP2B(3), PPAP2C(1)	8638336	148	48	142	43	45	55	20	3	24	1	0.18	1.00	1.00
463	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	22	POLR1A(16), POLR1B(16), POLR1C(2), POLR1D(3), POLR2A(21), POLR2B(22), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(2), POLR2K(2), POLR3A(7), POLR3B(14), POLR3G(3), POLR3GL(3), POLR3H(5)	8653712	130	48	129	36	45	45	17	2	20	1	0.18	1.00	1.00
464	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(8), FADD(1), IKBKB(13), IKBKG(4), IL1R1(5), IRAK1(4), MAP3K1(30), MAP3K14(6), MAP3K7(9), MYD88(3), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(9), TLR4(17), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF6(7)	8832768	144	48	143	33	31	56	26	1	27	3	0.068	1.00	1.00
465	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(5), BIRC2(10), BIRC3(5), CASP3(4), CASP8(21), CFLAR(6), FADD(1), IKBKG(4), JUN(1), MAP2K4(9), MAP3K3(9), MAP3K7(9), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NR2C2(7), RALBP1(6), RIPK1(9), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3)	9743672	147	48	144	38	36	60	24	0	25	2	0.11	1.00	1.00
466	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(15), G6PD(6), GCLC(8), GCLM(2), GGT1(5), GPX2(1), GPX3(2), GPX5(6), GPX6(7), GPX7(1), GSR(6), GSS(5), GSTA1(2), GSTA2(6), GSTA3(5), GSTA4(3), GSTA5(4), GSTK1(6), GSTM1(2), GSTM2(3), GSTM3(5), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTT1(1), GSTT2(1), GSTZ1(5), IDH1(4), IDH2(5), MGST1(4), MGST3(2), OPLAH(3), TXNDC12(5)	8494248	136	47	132	45	42	48	31	2	12	1	0.33	1.00	1.00
467	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(5), GALNS(4), GLB1(6), GNS(5), GUSB(5), HEXA(3), HEXB(5), HGSNAT(9), HPSE(6), HPSE2(11), HYAL1(2), HYAL2(4), IDS(8), IDUA(7), LCT(32), NAGLU(3), SPAM1(15)	7759176	130	47	130	53	29	56	26	3	16	0	0.87	1.00	1.00
468	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(5), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), CYP2C19(6), CYP2C9(5), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ECHS1(3), EHHADH(11), ESCO1(16), ESCO2(8), HADHA(5), NAT6(1), PNPLA3(7), SH3GLB1(7), YOD1(3)	11426104	124	47	123	42	38	51	21	2	12	0	0.53	1.00	1.00
469	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(4), POLD1(12), POLD2(6), POLE(47), POLG(6), POLL(7), POLQ(29)	6256792	111	46	98	30	32	57	15	1	6	0	0.16	1.00	1.00
470	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(8), DUSP1(2), IKBKAP(13), IKBKB(13), IKBKG(4), LTA(3), MAP3K1(30), MAP3K14(6), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(9), TANK(5), TNFAIP3(3), TNFRSF1B(2), TRAF1(5), TRAF2(3), TRAF3(5)	8449856	130	46	129	32	32	52	20	1	23	2	0.082	1.00	1.00
471	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(9), AGT(8), AGTR2(11), EDN1(4), EDNRA(5), EDNRB(4), EGF(20), EGFR(12), FOS(3), HRAS(1), JUN(1), MYC(8), NFKB1(10), PLCG1(12), PRKCA(10), RELA(6)	7598968	124	45	120	48	31	48	31	2	12	0	0.78	1.00	1.00
472	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), FPGT(6), GCK(3), GMDS(4), GMPPA(6), GMPPB(2), HK1(11), HK2(9), HK3(10), KHK(2), MPI(5), PFKFB1(8), PFKFB3(4), PFKFB4(4), PFKM(9), PFKP(8), PMM2(6), SORD(5), TPI1(2)	9192368	125	45	123	60	50	35	24	0	16	0	0.94	1.00	1.00
473	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(7), FUCA1(3), FUCA2(4), GLB1(6), HEXA(3), HEXB(5), LCT(32), MAN2B1(14), MAN2B2(5), MAN2C1(7), MANBA(12), NEU2(4), NEU3(3)	7001536	105	45	104	41	29	41	22	3	10	0	0.77	1.00	1.00
474	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(9), CA1(6), CA12(1), CA13(4), CA14(4), CA2(2), CA3(5), CA4(1), CA5A(6), CA5B(7), CA6(3), CA7(5), CA8(6), CA9(4), CPS1(22), CTH(6), GLS(11), GLS2(7), GLUD1(3), GLUD2(9), GLUL(7), HAL(6)	7845976	136	45	131	48	40	50	18	2	24	2	0.63	1.00	1.00
475	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL4(5), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR7(6), CD28(3), CD4(6), CSF2(1), CXCR3(5), CXCR4(1), IFNG(9), IFNGR1(5), IFNGR2(4), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL18R1(9), IL2(2), IL4(1), IL4R(6), IL5(2), TGFB1(2), TGFB2(5), TGFB3(9)	7614344	135	45	134	44	38	52	24	1	20	0	0.34	1.00	1.00
476	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), G6PD(6), GPI(7), H6PD(7), PFKM(9), PFKP(8), PGD(3), PGLS(2), PGM1(7), PGM3(4), PRPS1(3), PRPS1L1(5), PRPS2(7), RBKS(1), RPE(5), RPIA(9), TAL1(1), TALDO1(6), TKT(6)	7306080	116	45	112	42	44	38	20	1	13	0	0.39	1.00	1.00
477	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(8), CHUK(8), IFNG(9), IKBKB(13), IL2(2), IL4(1), JUN(1), MAP3K1(30), MAP3K5(25), MAP4K5(7), MAPK14(4), MAPK8(10), NFKB1(10), NFKBIA(3), RELA(6), TNFRSF9(2), TNFSF9(6), TRAF2(3)	7429088	148	44	144	40	40	63	20	1	22	2	0.24	1.00	1.00
478	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(4), CFL1(1), GNAQ(3), GNAS(24), GNB1(2), GNGT1(1), HRAS(1), LIMK1(8), MAP2K1(2), MAPK1(2), MAPK3(3), MYL2(2), NOX1(16), PIK3C2G(16), PLCB1(5), PPP1R12B(20), PRKCA(10), PTK2(12), RAF1(8), ROCK2(17)	9483520	157	44	152	49	48	50	34	3	22	0	0.57	1.00	1.00
479	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(5), CALCR(9), CALCRL(8), CD97(13), CRHR1(3), CRHR2(2), ELTD1(12), EMR1(22), EMR2(6), GHRHR(2), GIPR(5), GLP1R(5), GLP2R(11), GPR64(11), LPHN1(16), LPHN2(22), LPHN3(22), SCTR(5), VIPR1(3), VIPR2(4)	10445512	186	44	180	70	55	79	27	1	22	2	0.50	1.00	1.00
480	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(6), AMD1(3), BHMT(2), CBS(11), CTH(6), DNMT1(14), DNMT3A(8), DNMT3B(15), MARS(11), MARS2(4), MAT1A(4), MAT2B(12), MTAP(4), MTR(12), SRM(1), TAT(7)	7830104	120	44	117	52	47	40	20	1	12	0	0.86	1.00	1.00
481	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(19), CALM1(2), CALM2(4), CAPN2(11), CAPNS1(2), CAPNS2(3), EP300(32), HDAC1(5), HDAC2(5), MEF2D(7), NFATC1(10), NFATC2(13), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKCA(10), SYT1(4)	8798048	142	44	137	42	52	32	33	1	24	0	0.23	1.00	1.00
482	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(21), ADRB2(7), GNAS(24), PLCE1(41), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3)	5275952	120	44	116	34	44	29	29	1	16	1	0.19	1.00	1.00
483	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(17), BIRC2(10), BIRC3(5), CASP10(8), CASP3(4), CASP7(4), CASP8(21), CASP9(3), DFFB(4), GZMB(4), PRF1(8), SCAP(12), SREBF1(2), SREBF2(14)	6790736	116	44	111	37	31	44	17	0	24	0	0.41	1.00	1.00
484	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(12), DYRK1B(4), GLI2(10), GLI3(28), GSK3B(13), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), SHH(4), SMO(9), SUFU(3)	5860240	110	44	107	55	39	39	12	3	15	2	0.90	1.00	1.00
485	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(7), CYB5R3(5), GCK(3), GFPT1(9), GNE(10), GNPDA1(2), GNPDA2(10), HEXA(3), HEXB(5), HK1(11), HK2(9), HK3(10), PGM3(4), RENBP(4), UAP1(6)	6477016	98	43	97	36	35	25	23	1	14	0	0.70	1.00	1.00
486	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(5), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH3B2(7), ALDH9A1(2), AOC2(7), AOC3(10), ASPA(5), CNDP1(4), DDC(9), HAL(6), HARS(5), HDC(9), HNMT(4), MAOA(12), MAOB(7), PRPS1(3), PRPS2(7)	9095648	150	43	144	53	45	50	32	3	20	0	0.45	1.00	1.00
487	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(12), EXT2(6), EXTL1(9), EXTL2(8), EXTL3(10), GLCE(5), HS2ST1(7), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), HS3ST5(9), HS6ST1(4), HS6ST2(12), HS6ST3(3), NDST1(14), NDST2(9), NDST3(14), NDST4(15)	7657744	154	43	151	45	44	60	32	1	16	1	0.17	1.00	1.00
488	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(10), GALNT10(8), GALNT2(9), GALNT3(7), GALNT4(8), GALNT6(1), GALNT7(13), GALNT8(11), GALNT9(8), GCNT1(5), ST3GAL1(2), ST3GAL2(6), ST3GAL4(3), WBSCR17(16)	5487744	107	43	105	32	29	40	27	1	10	0	0.34	1.00	1.00
489	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(5), EPHA4(19), EPHB1(26), FYN(7), ITGA1(17), ITGB1(8), L1CAM(20), LYN(9), RAP1B(2), SELP(12)	5880080	125	42	122	38	40	47	22	1	15	0	0.19	1.00	1.00
490	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(3), B4GALNT1(6), GLB1(6), HEXA(3), HEXB(5), LCT(32), SLC33A1(9), ST3GAL1(2), ST3GAL2(6), ST3GAL5(5), ST6GALNAC3(8), ST6GALNAC4(4), ST6GALNAC5(2), ST6GALNAC6(6), ST8SIA1(2), ST8SIA5(8)	6046240	107	42	105	40	31	42	18	2	14	0	0.62	1.00	1.00
491	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(5), ADCY1(21), CAP1(7), CCNB1(8), CDC25C(5), GNAI1(5), GNAS(24), GNB1(2), GNGT1(1), HRAS(1), MAPK1(2), MAPK3(3), MYT1(18), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RPS6KA1(1), SRC(3)	7533496	133	42	129	40	50	41	23	1	17	1	0.14	1.00	1.00
492	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(9), CA1(6), CA12(1), CA14(4), CA2(2), CA3(5), CA4(1), CA5A(6), CA5B(7), CA6(3), CA7(5), CA8(6), CA9(4), CPS1(22), CTH(6), GLS(11), GLS2(7), GLUD1(3), GLUL(7), HAL(6)	7031296	123	42	118	37	34	46	17	2	22	2	0.33	1.00	1.00
493	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(17), ARHGDIB(3), BIRC2(10), BIRC3(5), CASP1(8), CASP10(8), CASP2(6), CASP3(4), CASP4(5), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CYCS(2), DFFB(4), GZMB(4), LMNA(8), LMNB1(5), LMNB2(4), PRF1(8)	7183568	136	41	130	42	36	52	21	1	26	0	0.51	1.00	1.00
494	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(6), CSF1(6), CSF2(1), CSF3(1), IFNA1(2), IFNB1(3), IFNG(9), IL10(3), IL11(2), IL12A(5), IL12B(2), IL15(2), IL2(2), IL3(2), IL4(1), IL5(2), IL6(5), IL7(1), IL8(3), LTA(3), PDGFA(3), TGFB1(2), TGFB2(5), TGFB3(9)	4722912	80	41	79	28	23	37	11	1	8	0	0.48	1.00	1.00
495	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(6), BHMT(2), CBS(11), CTH(6), DNMT1(14), DNMT3A(8), DNMT3B(15), MARS(11), MARS2(4), MAT1A(4), MAT2B(12), MTR(12)	6596056	105	41	102	43	42	34	16	1	12	0	0.76	1.00	1.00
496	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(21), ARHGEF1(12), GNA12(8), GNA13(7), GNAQ(3), GNB1(2), GNGT1(1), MYL2(2), MYLK(14), PLCB1(5), PPP1R12B(20), PRKCA(10), ROCK1(22)	7775296	127	41	123	50	43	41	27	2	11	3	0.86	1.00	1.00
497	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	9	CD80(5), CR1(22), CR2(24), FCGR2B(3), ICAM1(2), ITGAL(17), ITGB2(14), PTPRC(17)	5512544	104	40	103	30	33	38	17	2	13	1	0.14	1.00	1.00
498	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM1(2), CALM2(4), CDKN1A(1), GNAQ(3), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKCA(10), SP1(7), SP3(11), SYT1(4)	7328648	111	40	106	44	40	34	23	0	14	0	0.80	1.00	1.00
499	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(12), CSF1R(8), EGF(20), EGFR(12), GRB2(3), MET(17), PDGFRA(24), PRKCA(10), SH3GLB1(7), SH3GLB2(6), SH3KBP1(7), SRC(3)	7291200	129	40	126	44	34	45	32	0	16	2	0.45	1.00	1.00
500	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(5), C1QB(3), C1R(11), C1S(8), C2(3), C3(22), C5(18), C6(16), C7(20), C8A(9), C9(19), MASP1(15), MASP2(7), MBL2(4)	7805304	160	40	153	56	35	77	30	0	16	2	0.62	1.00	1.00
501	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(15), CD2(4), CD33(6), CD5(10), CD7(3), CSF2(1), IFNA1(2), IFNB1(3), IFNG(9), IL10(3), IL12A(5), IL12B(2), IL3(2), IL4(1), IL5(2), ITGAX(14), TLR2(16), TLR4(17), TLR7(17), TLR9(6)	6988888	138	40	136	41	41	58	20	1	16	2	0.093	1.00	1.00
502	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(15), G6PD(6), GCLC(8), GCLM(2), GGT1(5), GPX2(1), GPX3(2), GPX5(6), GSS(5), GSTA1(2), GSTA2(6), GSTA3(5), GSTA4(3), GSTM1(2), GSTM2(3), GSTM3(5), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTT1(1), GSTT2(1), GSTZ1(5), IDH1(4), IDH2(5), MGST1(4), MGST3(2), PGD(3)	7009968	107	40	104	34	29	42	26	1	8	1	0.33	1.00	1.00
503	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(18), BST1(1), CD38(6), ENPP1(12), ENPP3(18), NADK(9), NADSYN1(6), NMNAT1(3), NMNAT2(3), NMNAT3(1), NNMT(6), NNT(7), NT5C(1), NT5C1A(2), NT5C1B(8), NT5C2(6), NT5C3(8), NT5E(6), NT5M(3), NUDT12(4), QPRT(2)	8008416	130	40	127	38	42	44	38	0	6	0	0.17	1.00	1.00
504	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	11	AGA(7), FUCA1(3), FUCA2(4), GLB1(6), HEXA(3), HEXB(5), LCT(32), MAN2C1(7), MANBA(12), NEU2(4), NEU3(3)	5584464	86	40	85	32	19	33	22	2	10	0	0.78	1.00	1.00
505	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(3), BLVRA(1), BLVRB(1), CP(15), CPOX(6), EPRS(15), FECH(7), GUSB(5), HCCS(1), HMBS(8), HMOX1(4), HMOX2(3), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2B15(9), UGT2B4(11), UROD(3), UROS(3)	10184616	141	40	136	44	43	64	20	1	13	0	0.41	1.00	1.00
506	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(11), GTF2A1(3), GTF2B(5), GTF2E1(3), GTF2F1(7), HDAC3(12), NCOA1(19), NCOA2(15), NCOA3(10), NCOR2(23), POLR2A(21), RARA(2), RXRA(3), TBP(3)	9570816	137	40	134	48	54	41	27	1	14	0	0.50	1.00	1.00
507	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(2), CALM2(4), CCL4(5), CCR5(6), CXCL12(6), CXCR4(1), FOS(3), GNAQ(3), JUN(1), MAPK14(4), MAPK8(10), PLCG1(12), PRKCA(10), PTK2B(16), SYT1(4)	5049032	87	39	84	35	29	31	18	0	9	0	0.75	1.00	1.00
508	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(5), C1QB(3), C1R(11), C1S(8), C2(3), C3(22), C5(18), C6(16), C7(20), C8A(9), C8B(5), C9(19), MASP1(15)	7543416	154	39	146	53	34	70	31	0	17	2	0.60	1.00	1.00
509	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(4), GABARAP(1), GABRA1(14), GABRA2(14), GABRA3(14), GABRA4(19), GABRA5(10), GABRA6(7), GPHN(18), NSF(3), SRC(3), UBQLN1(6)	4508888	113	39	107	33	32	47	21	0	13	0	0.26	1.00	1.00
510	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(6), ABP1(5), AOC2(7), AOC3(10), CES1(13), DDHD1(10), ESCO1(16), ESCO2(8), LIPA(8), NAT6(1), PLA1A(6), PNPLA3(7), PPME1(3), PRDX6(4), SH3GLB1(7)	9313144	111	39	107	40	27	45	24	0	14	1	0.75	1.00	1.00
511	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(3), BET1L(1), BNIP1(4), GOSR1(3), GOSR2(1), SNAP23(3), SNAP25(9), SNAP29(4), STX10(1), STX11(6), STX12(3), STX16(1), STX17(1), STX18(2), STX19(3), STX2(7), STX3(7), STX4(6), STX5(6), STX6(3), STX7(6), STX8(3), TSNARE1(3), USE1(4), VAMP1(1), VAMP3(1), VAMP4(1), VAMP5(1), VAMP7(4), VTI1A(1), VTI1B(6), YKT6(4)	6301184	109	39	105	32	40	33	21	0	15	0	0.34	1.00	1.00
512	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(2), ATG5(3), ATG7(5), BECN1(1), GABARAP(1), GABARAPL1(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNG(9), INS(3), PIK3C3(14), PIK3R4(21), PRKAA1(8), PRKAA2(10), ULK1(5), ULK2(12), ULK3(5)	8064960	138	39	137	41	33	65	25	0	15	0	0.45	1.00	1.00
513	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(14), ABCC2(30), ABCG2(16), BCHE(17), CES1(13), CES2(2), CYP3A4(10), CYP3A5(6), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4)	8476144	154	39	150	45	35	66	40	0	11	2	0.17	1.00	1.00
514	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(21), GNAS(24), GNB1(2), GNGT1(1), PPP2CA(6), PRKAA1(8), PRKAA2(10), PRKAB1(6), PRKAB2(1), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAG2(4), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3)	5543792	113	38	109	36	46	33	16	2	15	1	0.37	1.00	1.00
515	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(20), EGFR(12), MAP2K1(2), MAP3K1(30), MAPK14(4), NCOR2(23), RARA(2), RXRA(3), THRA(6), THRB(4)	6608952	106	38	104	39	30	35	22	1	17	1	0.69	1.00	1.00
516	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(5), GALNS(4), GLB1(6), GNS(5), GUSB(5), HEXA(3), HEXB(5), IDS(8), IDUA(7), LCT(32), NAGLU(3)	5409624	83	38	83	34	20	32	18	3	10	0	0.78	1.00	1.00
517	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(33), ACACB(29), FASN(8), MCAT(3), OLAH(7), OXSM(6)	6100304	86	38	82	38	33	25	15	3	8	2	0.79	1.00	1.00
518	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(6), CD2(4), CD3D(6), CD3E(2), CD3G(3), CD4(6), CXCR3(5), IFNG(9), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), JAK2(17), STAT4(7), TYK2(10)	5620920	105	38	104	31	22	48	18	1	13	3	0.35	1.00	1.00
519	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(8), F2R(6), GNAI1(5), GNB1(2), GNGT1(1), HRAS(1), ITGA1(17), ITGB1(8), MAP2K1(2), MAPK1(2), MAPK3(3), PLA2G4A(13), PLCB1(5), PRKCA(10), PTGS1(6), PTK2(12), RAF1(8), SRC(3), SYK(4), TBXAS1(7)	9085232	123	38	122	48	30	44	29	4	16	0	0.82	1.00	1.00
520	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(2), CDK5R1(3), CSNK1D(3), DRD1(7), DRD2(8), GRM1(29), PLCB1(5), PPP1CA(3), PPP1R1B(2), PPP2CA(6), PPP3CA(4), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3)	5963408	99	37	98	44	31	38	12	4	13	1	0.79	1.00	1.00
521	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(9), CARS2(5), CDO1(4), CTH(6), GOT1(9), GOT2(3), LDHA(8), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(4), MPST(1), SDS(1), SULT1B1(7), SULT1C2(4), SULT1C4(4), SULT4A1(4)	4618752	82	37	79	33	19	32	19	2	10	0	0.88	1.00	1.00
522	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(5), ACP2(1), ACP5(5), ACP6(4), ACPP(5), ACPT(5), ALPI(4), ALPL(5), ALPP(4), ALPPL2(3), CMBL(3), CYP3A4(10), CYP3A43(4), CYP3A5(6), CYP3A7(7), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), PON1(12), PON2(6), PON3(5)	6773624	110	37	108	32	25	42	27	1	15	0	0.19	1.00	1.00
523	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(4), IL22RA1(4), IL22RA2(1), JAK1(20), JAK2(17), JAK3(10), STAT1(15), STAT3(10), STAT5A(5), STAT5B(7), TYK2(10)	6923416	103	37	102	42	29	39	18	0	14	3	0.79	1.00	1.00
524	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ATP6V0C(1), CAT(4), EPX(15), LPO(6), MPO(10), PRDX2(4), PRDX5(1), PRDX6(4), SHMT1(5), SHMT2(5), TPO(15)	4443168	70	37	68	28	29	26	8	1	6	0	0.66	1.00	1.00
525	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(5), ICAM1(2), ITGA4(10), ITGAL(17), ITGAM(21), ITGB1(8), ITGB2(14), SELE(5), SELL(5), SELP(12)	6177432	99	37	95	36	28	41	14	1	14	1	0.56	1.00	1.00
526	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(2), CALM2(4), CAMK1(2), CAMK1G(5), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CAMK4(5), ESRRA(2), HDAC5(12), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), PPARA(1), PPP3CA(4), PPP3CB(5), PPP3CC(6), SLC2A4(9), SYT1(4), YWHAH(3)	7969232	108	37	107	39	42	31	20	0	15	0	0.47	1.00	1.00
527	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(3), ALDH18A1(9), ARG1(5), ARG2(3), ASL(2), CKM(3), CKMT1A(1), CKMT2(4), CPS1(22), GAMT(3), GATM(5), GLUD1(3), NAGS(3), OAT(7), ODC1(2), OTC(7), PYCR1(3), SMS(8)	6688808	93	37	92	37	29	33	17	2	10	2	0.82	1.00	1.00
528	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(5), C1QB(3), C1R(11), C1S(8), C2(3), C3(22), C5(18), C6(16), C7(20), C8A(9), C9(19)	6320032	134	36	128	46	25	62	29	0	16	2	0.66	1.00	1.00
529	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(4), EPX(15), LPO(6), MPO(10), MTHFR(10), PRDX6(4), SHMT1(5), SHMT2(5), TPO(15)	4310984	74	36	71	27	32	24	8	2	8	0	0.53	1.00	1.00
530	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(10), AMT(2), ATIC(7), ATP6V0C(1), DHFR(4), GART(9), MTHFD1(6), MTHFD1L(15), MTHFD2(4), MTHFR(10), MTR(12), SHMT1(5), SHMT2(5)	6711872	90	36	87	32	37	31	13	1	8	0	0.39	1.00	1.00
531	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(11), ESR2(5), ITPKA(1), PDE1A(15), PDE1B(7), PLCB1(5), PLCB2(8), PRL(6), TRH(1), VIP(3)	4096464	62	36	61	29	17	19	16	3	7	0	0.97	1.00	1.00
532	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(5), ACTR2(6), ACTR3(1), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), NCK1(4), NCKAP1(8), NTRK1(13), PIR(6), PSMA7(2), RAC1(1), WASF1(3), WASF2(3), WASF3(8), WASL(9)	5786336	83	35	83	29	26	39	10	0	8	0	0.57	1.00	1.00
533	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(3), IL4(1), IL5(2), MAF(2), MAP2K3(7), MAPK14(4), NFATC1(10), NFATC2(13), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3)	4112088	69	35	67	30	26	20	13	1	8	1	0.59	1.00	1.00
534	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(10), AMT(2), ATIC(7), DHFR(4), FTCD(8), GART(9), MTHFD1(6), MTHFD1L(15), MTHFD2(4), MTHFR(10), MTR(12), SHMT1(5), SHMT2(5)	7107680	97	35	94	34	38	34	16	1	8	0	0.40	1.00	1.00
535	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(11), ACO1(17), ACO2(7), ACSS1(5), ACSS2(8), FH(8), IDH1(4), IDH2(5), MDH1(4), MDH2(4), SUCLA2(5)	4980584	78	35	76	32	30	24	15	0	9	0	0.72	1.00	1.00
536	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(32), ABCB11(15), ABCB4(27), ABCC1(14), ABCC3(13), GSTP1(2)	5467408	103	35	100	38	21	39	25	0	15	3	0.66	1.00	1.00
537	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(2), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT5(2), DDOST(3), DPAGT1(3), DPM1(2), FUT8(13), MAN1A1(13), MAN1B1(5), MGAT1(4), MGAT2(4), MGAT3(4), MGAT4A(5), MGAT4B(6), MGAT5(11), RPN1(3), RPN2(5), ST6GAL1(7)	7102472	110	35	102	33	39	35	27	1	8	0	0.31	1.00	1.00
538	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(8), ADSS(6), DHFR(4), HPRT1(2), IMPDH1(6), MTHFD2(4), OAZ1(1), POLB(4), POLD1(12), POLG(6), PRPS2(7), RRM1(2), SRM(1)	4774496	63	35	61	26	23	21	12	1	6	0	0.82	1.00	1.00
539	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(15), GBA3(9), LPO(6), MPO(10), PRDX2(4), PRDX5(1), PRDX6(4), TPO(15), TYR(12)	3633448	76	35	74	27	25	29	14	1	7	0	0.55	1.00	1.00
540	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(11), CYP2A13(8), CYP2A6(11), CYP2A7(5), NAT1(7), NAT2(4), XDH(14)	3015680	60	34	56	21	19	30	8	0	3	0	0.43	1.00	1.00
541	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(4), B3GAT2(1), B3GAT3(2), B4GALT7(4), CHPF(5), CHST11(8), CHST12(3), CHST14(3), CHST3(4), CHST7(4), CHSY1(8), DSE(19), UST(3), XYLT1(16), XYLT2(4)	4578824	88	34	87	34	35	28	21	0	4	0	0.63	1.00	1.00
542	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(33), CPT1A(9), LEP(2), LEPR(12), PRKAA1(8), PRKAA2(10), PRKAB1(6), PRKAB2(1), PRKAG1(3), PRKAG2(4)	5402184	88	34	85	26	26	33	14	2	13	0	0.44	1.00	1.00
543	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(15), CKM(3), EIF4E(2), FBL(3), GPT(2), LDHA(8), LDHB(3), LDHC(4), MAPK14(4), NCL(7)	3422648	51	34	51	24	9	20	11	3	7	1	0.95	1.00	1.00
544	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(3), CD3D(6), CD3E(2), CD3G(3), IFNG(9), IL2(2), IL2RA(4), IL4(1), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6), TGFBR3(15), TOB1(4), TOB2(5)	4004952	81	34	81	31	25	35	11	1	9	0	0.76	1.00	1.00
545	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(2), ACHE(4), CHAT(5), COMT(3), DBH(9), DDC(9), GAD1(6), GAD2(12), HDC(9), MAOA(12), PAH(2), PNMT(2), SLC18A3(7), TH(3), TPH1(9)	5335472	94	33	92	32	29	28	20	1	14	2	0.30	1.00	1.00
546	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(5), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), CHST1(8), CHST2(2), CHST4(4), CHST6(6), FUT8(13), ST3GAL1(2), ST3GAL2(6), ST3GAL3(10), ST3GAL4(3)	4287672	85	33	81	39	38	26	14	1	6	0	0.84	1.00	1.00
547	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(15), GBA(4), GBA3(9), LPO(6), MPO(10), PRDX6(4), TPO(15)	3131744	63	33	61	24	22	25	9	1	6	0	0.63	1.00	1.00
548	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(6), CBS(11), CTH(6), GGT1(5), MARS(11), MARS2(4), MAT1A(4), MAT2B(12), PAPSS1(8), PAPSS2(7), SCLY(3), SEPHS1(12)	4646528	89	33	86	32	40	29	11	1	8	0	0.42	1.00	1.00
549	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(6), GRB2(3), HBXIP(1), HRAS(1), PTK2B(16), SHC1(7), SOS1(13), SRC(3)	3262192	50	32	47	16	16	22	10	0	2	0	0.52	1.00	1.00
550	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA2(4), PSMA3(5), PSMA4(2), PSMA5(2), PSMA6(1), PSMA7(2), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(2), PSMC2(3), PSMC3(1), PSMD1(12), PSMD11(6), PSMD12(5), PSMD13(1), PSMD2(10), PSMD6(3)	6027640	78	32	74	26	21	24	13	0	20	0	0.64	1.00	1.00
551	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), BLVRB(1), HMOX1(4), IL10(3), IL10RA(4), IL10RB(6), IL6(5), JAK1(20), STAT1(15), STAT3(10), STAT5A(5)	4421096	74	32	73	29	25	21	13	0	15	0	0.69	1.00	1.00
552	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), ECHS1(3), EHHADH(11), HADHA(5), SDS(1)	4545096	70	32	69	30	20	26	16	2	6	0	0.76	1.00	1.00
553	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(2), ITGAL(17), ITGAM(21), ITGB2(14), SELE(5), SELL(5)	4109112	69	32	68	32	21	27	9	1	10	1	0.86	1.00	1.00
554	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(4), GNAS(24), GNB1(2), GNGT1(1), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10)	3513664	68	31	65	25	29	18	10	1	9	1	0.68	1.00	1.00
555	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(29), GNA12(8), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAR2A(4), PRKAR2B(3)	3720000	59	31	57	21	15	21	14	0	8	1	0.71	1.00	1.00
556	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(20), JAK2(17), JAK3(10), MAPK1(2), MAPK3(3), STAT3(10), TYK2(10)	4401008	72	31	72	27	16	25	15	0	13	3	0.71	1.00	1.00
557	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(6), GNAQ(3), GNB1(2), GNGT1(1), HTR2C(17), PLCB1(5), TUB(13)	2648144	47	31	45	19	16	12	10	4	5	0	0.76	1.00	1.00
558	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(6), AKR1D1(8), CYP11A1(9), CYP11B1(8), CYP11B2(9), CYP17A1(3), CYP21A2(7), HSD11B1(6), HSD3B1(3), HSD3B2(6)	3585584	65	30	65	25	18	25	10	1	11	0	0.66	1.00	1.00
559	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(4), DHCR7(2), FDFT1(1), FDPS(8), HMGCR(12), HMGCS1(6), IDI1(3), LSS(6), MVD(3), MVK(3), NSDHL(10), PMVK(3), SC5DL(3), SQLE(5)	4983808	69	30	68	30	18	26	18	0	7	0	0.87	1.00	1.00
560	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(11), KHK(2), LCT(32), MPI(5), PGM1(7), PYGL(8), PYGM(10), TPI1(2), TREH(2)	5057960	79	30	79	38	20	32	19	0	8	0	0.94	1.00	1.00
561	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(8), CYP51A1(4), DHCR24(6), DHCR7(2), EBP(2), FDFT1(1), FDPS(8), GGCX(10), GGPS1(2), HMGCR(12), HSD17B7(5), IDI1(3), IDI2(1), LSS(6), MVD(3), MVK(3), NQO1(3), NSDHL(10), PMVK(3), SC5DL(3), SQLE(5), TM7SF2(2), VKORC1(1)	7213080	103	30	102	49	29	46	19	0	9	0	0.97	1.00	1.00
562	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(6), AKR1D1(8), CYP11A1(9), CYP11B1(8), CYP11B2(9), CYP17A1(3), CYP21A2(7), HSD11B1(6), HSD3B1(3), HSD3B2(6)	3585584	65	30	65	25	18	25	10	1	11	0	0.66	1.00	1.00
563	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(3), HK1(11), HK2(9), HK3(10), IMPA1(4), IMPA2(6), ISYNA1(2), PGM1(7), PGM3(4), TGDS(4)	4372984	60	30	60	31	23	17	14	0	6	0	0.92	1.00	1.00
564	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(5), ACOX1(7), ACOX3(8), ELOVL2(8), ELOVL5(2), ELOVL6(4), FADS1(4), FADS2(2), FASN(8), HADHA(5), HSD17B12(4), PECR(6), SCD(6)	5552224	69	30	68	30	26	23	12	1	7	0	0.67	1.00	1.00
565	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(5), ICAM1(2), ITGA4(10), ITGAL(17), ITGB1(8), ITGB2(14), SELE(5), SELL(5)	4654960	66	30	64	29	21	24	12	1	8	0	0.83	1.00	1.00
566	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA2(4), PSMA3(5), PSMA4(2), PSMA5(2), PSMA6(1), PSMA7(2), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(2), PSMC3(1), PSMD14(2), RPN1(3), RPN2(5), UBE2A(3), UBE3A(16)	4938176	67	30	65	24	21	15	15	1	15	0	0.72	1.00	1.00
567	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(17), ACO2(7), FH(8), IDH1(4), IDH2(5), MDH1(4), MDH2(4), SDHB(2), SUCLA2(5)	3369328	56	30	55	24	25	15	11	0	5	0	0.74	1.00	1.00
568	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(11), ERBB4(27), NRG2(4), NRG3(17), PRKCA(10), PSEN1(5)	3407272	74	29	73	28	24	24	17	0	8	1	0.75	1.00	1.00
569	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(8), CYSLTR2(5), GPR161(6), GPR171(5), GPR18(3), GPR34(9), GPR39(9), GPR45(3), GPR65(11), GPR68(6), GPR75(8)	3691480	73	29	68	32	28	21	20	0	4	0	0.74	1.00	1.00
570	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(3), EHHADH(11), HADH(1), HADHA(5), HSD17B10(4), HSD17B4(13), NTAN1(3), SIRT1(6), SIRT2(8), SIRT5(5), SIRT7(6), VNN2(11)	4456808	77	29	75	24	20	31	19	0	7	0	0.50	1.00	1.00
571	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(5), FOS(3), HRAS(1), JUN(1), MAP2K1(2), MAPK1(2), MAPK3(3), MYC(8), NFKB1(10), NFKBIA(3), PLCB1(5), PRKCA(10), RAF1(8), RELA(6)	5595872	67	28	66	29	19	21	20	2	5	0	0.85	1.00	1.00
572	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(8), CYP11A1(9), CYP11B2(9), CYP17A1(3), HSD11B1(6), HSD3B1(3), HSD3B2(6)	2555888	44	28	44	19	12	16	8	0	8	0	0.70	1.00	1.00
573	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(11), CS(6), MDH1(4), ME1(12), PC(12), PDHA1(7), SLC25A1(2), SLC25A11(3)	3483904	57	28	56	25	17	26	8	1	5	0	0.80	1.00	1.00
574	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(2), CDK5R1(3), DAB1(6), FYN(7), LRP8(4), RELN(48), VLDLR(4)	5206760	74	28	71	32	11	34	20	1	7	1	0.93	1.00	1.00
575	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(6), LDLR(6), MBTPS1(9), MBTPS2(10), SCAP(12), SREBF1(2), SREBF2(14)	4460528	59	28	58	26	23	20	10	0	6	0	0.74	1.00	1.00
576	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(9), CTH(6), GOT1(9), GOT2(3), LDHA(8), LDHB(3), LDHC(4), MPST(1)	2460408	43	27	42	16	8	19	10	1	5	0	0.81	1.00	1.00
577	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(2), B3GALNT1(6), B3GALT5(4), FUT1(4), FUT2(1), FUT9(9), GBGT1(7), GLA(9), HEXA(3), HEXB(5), NAGA(3), ST3GAL1(2), ST3GAL2(6), ST8SIA1(2)	3895584	63	27	59	25	20	27	10	1	5	0	0.66	1.00	1.00
578	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(7), CS(6), FH(8), IDH2(5), MDH1(4), OGDH(13), SDHA(15), SUCLA2(5)	3587816	63	27	62	24	28	19	13	0	3	0	0.49	1.00	1.00
579	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(14), CD44(5), CSF1(6), FCGR3A(1), IL1B(2), IL6R(7), SELL(5), SPN(1), TGFB1(2), TGFB2(5), TNFRSF1A(4), TNFRSF1B(2), TNFRSF8(8), TNFSF8(1)	4901472	63	27	60	29	20	21	13	0	9	0	0.87	1.00	1.00
580	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK1(11), HK2(9), HK3(10), IMPA1(4), PGM1(7), PGM3(4), TGDS(4)	3844496	52	27	52	26	18	16	13	0	5	0	0.91	1.00	1.00
581	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDFT1(1), FDPS(8), HMGCR(12), IDI1(3), LSS(6), MVD(3), MVK(3), NQO1(3), NQO2(5), PMVK(3), SC5DL(3), SQLE(5), VKORC1(1)	4159456	58	26	56	27	16	24	13	0	5	0	0.89	1.00	1.00
582	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(4), CASP7(4), DFFB(4), ENDOG(1), GZMB(4), HMGB1(4), HMGB2(4), TOP2A(14), TOP2B(24)	3965768	63	26	62	20	9	22	16	0	16	0	0.84	1.00	1.00
583	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(2), FUT1(4), FUT2(1), FUT9(9), GBGT1(7), GLA(9), HEXA(3), HEXB(5), NAGA(3), ST3GAL1(2), ST3GAL2(6), ST3GAL4(3), ST8SIA1(2)	3671392	56	26	55	23	18	24	11	1	2	0	0.72	1.00	1.00
584	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(12), PRKCA(10), PTK2B(16)	2492400	41	26	40	25	20	11	9	0	1	0	0.99	1.00	1.00
585	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(5), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT5(2), FUT8(13), ST3GAL1(2), ST3GAL2(6), ST3GAL3(10), ST3GAL4(3)	2918216	58	26	54	18	25	17	11	1	4	0	0.39	1.00	1.00
586	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(8), CDC25A(8), CDC25B(3), CDC25C(5), CSK(1), GRB2(3), PRKCA(10), PTPRA(10), SRC(3)	3471752	51	26	50	26	19	10	14	0	8	0	0.96	1.00	1.00
587	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(6), AASDH(10), AASDHPPT(9), AASS(12), KARS(5)	2596560	42	25	39	19	6	19	12	1	4	0	0.95	1.00	1.00
588	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(3), NFKB1(10), NFKBIA(3), PLCB1(5), PRKCA(10), RELA(6)	3056352	37	25	37	22	10	11	9	2	5	0	0.99	1.00	1.00
589	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(6), MMP2(7), MMP9(12), RECK(13), TIMP1(4), TIMP2(2), TIMP3(9), TIMP4(1)	2862416	55	25	54	20	15	24	10	0	6	0	0.51	1.00	1.00
590	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(4), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), XYLT1(16), XYLT2(4)	2281104	43	24	43	16	21	11	8	0	3	0	0.51	1.00	1.00
591	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(4), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), XYLT1(16), XYLT2(4)	2281104	43	24	43	16	21	11	8	0	3	0	0.51	1.00	1.00
592	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(7), CAMP(1), DAG1(6), GNAQ(3), ITPKA(1), ITPKB(12)	2168264	30	24	30	11	10	14	1	0	5	0	0.52	1.00	1.00
593	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(6), ACAT2(4), ACYP1(2), ECHS1(3), EHHADH(11), GCDH(6), HADHA(5), SDHB(2), SDS(1)	2951200	40	23	40	15	7	18	12	0	3	0	0.72	1.00	1.00
594	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(5), ACAA2(3), ACAT1(6), ACAT2(4), ECHS1(3), EHHADH(11), HADHA(5), HADHB(4), SDS(1)	3163488	42	23	42	16	11	14	14	0	3	0	0.68	1.00	1.00
595	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(3), ALAS1(8), ALAS2(11), CPOX(6), FECH(7), HMBS(8), UROD(3), UROS(3)	2927888	49	23	47	13	20	17	7	0	5	0	0.35	1.00	1.00
596	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), MIOX(6), UGDH(2)	3152576	39	23	38	16	18	13	4	2	2	0	0.59	1.00	1.00
597	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(4), EPHX2(7), HSD3B7(5), RDH11(1), RDH12(5), RDH13(4), RDH14(2)	1771960	28	23	28	12	12	9	4	1	2	0	0.69	1.00	1.00
598	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(4), CHAT(5), CHKA(9), PCYT1A(4), PDHA1(7), PDHA2(10), PEMT(1), SLC18A3(7)	2539768	47	22	46	25	11	20	9	1	5	1	0.91	1.00	1.00
599	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	BPNT1(3), CHST11(8), CHST12(3), PAPSS1(8), PAPSS2(7), SULT1A1(4), SULT1A2(1), SULT1E1(9), SULT2A1(7), SULT2B1(4), SUOX(2)	3156048	56	22	52	18	28	20	5	0	3	0	0.41	1.00	1.00
600	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(11), DLL1(7), FURIN(6), NOTCH1(11), PSEN1(5)	3474728	40	22	40	25	16	15	5	0	4	0	0.93	1.00	1.00
601	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(5), AOC2(7), AOC3(10), CES1(13), ESD(2)	2137512	37	21	34	15	9	12	12	0	4	0	0.73	1.00	1.00
602	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(6), AASDHPPT(9), AASS(12), KARS(5)	1774936	32	21	29	13	6	17	7	1	1	0	0.89	1.00	1.00
603	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(3), ADORA2A(6), ADORA2B(1), ADORA3(5), LTB4R(2), P2RY1(3), P2RY2(3), P2RY6(4)	2058648	27	21	27	14	11	7	9	0	0	0	0.82	1.00	1.00
604	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(2), CDK5R1(3), DPM2(2), EGR1(6), HRAS(1), KLK2(2), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), NGFR(3), RAF1(8)	3068256	39	20	38	20	19	12	7	0	1	0	0.81	1.00	1.00
605	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(16), MTMR2(5), MTMR6(10), NFS1(5), PHPT1(1), TPK1(3)	2402872	42	20	41	13	10	17	6	0	9	0	0.65	1.00	1.00
606	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(6), PLCD1(5), PRKCA(10), TGM2(10)	1840656	31	20	31	17	15	7	7	0	2	0	0.89	1.00	1.00
607	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(4), ALPL(5), ALPP(4), ALPPL2(3), DHFR(4), FPGS(5), GCH1(1), GGH(2), SPR(1)	2384520	29	19	29	13	11	11	4	0	3	0	0.63	1.00	1.00
608	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(11), GLS2(7), GLUD1(3), GLUD2(9)	1662344	30	19	29	14	9	7	6	0	8	0	0.94	1.00	1.00
609	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(4), CASP8(21), CFL1(1), CFLAR(6), PDE6D(2)	1412856	34	19	32	11	4	15	6	0	9	0	0.67	1.00	1.00
610	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(8), CYCS(2), GPD2(3), NDUFA1(1), SDHA(15), SDHB(2), SDHC(4), SDHD(3), UQCRC1(2)	2411304	40	18	40	13	18	13	7	0	2	0	0.53	1.00	1.00
611	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(4), GBA3(9), GGT1(5), SHMT1(5), SHMT2(5)	2155120	28	18	28	12	9	12	3	0	4	0	0.68	1.00	1.00
612	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(3), EHHADH(11), HADHA(5), SDS(1)	1843384	21	17	21	16	3	9	8	0	1	0	1.00	1.00	1.00
613	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(3), PAPSS1(8), PAPSS2(7), SULT1A2(1), SULT1E1(9), SULT2A1(7), SUOX(2)	2267464	37	17	34	11	18	13	3	0	3	0	0.62	1.00	1.00
614	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(10), ALDH1A2(11), BCMO1(3), RDH5(3)	1444352	27	16	27	13	7	11	4	0	5	0	0.86	1.00	1.00
615	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(18), PDXK(4), PNPO(1), PSAT1(5)	1788576	28	15	28	13	7	13	5	0	3	0	0.85	1.00	1.00
616	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	7	CD28(3), CD4(6), CD80(5), IL10(3), IL2(2), IL4(1)	1242480	20	14	20	11	5	7	3	1	4	0	0.94	1.00	1.00
