Hybridization REF p difference q subclass Composite Element REF p difference q subclass CCNB1|CYCLIN_B1-R-V 1.34055431220391e-29 1.08783733107253 3.1598780216235e-28 1 CASP7|CASPASE-7_CLEAVEDD198-R-C 3.24382537377379e-13 0.699316527923492 1.67259745835211e-12 1 SYK|SYK-M-V 2.68431848824878e-17 0.636318709229525 1.84546896067104e-16 1 MSH6|MSH6-R-C 1.29804452587205e-14 0.614638501523271 7.93249432477364e-14 1 CCNE1|CYCLIN_E1-M-V 4.59061284544743e-18 0.586744443198486 3.60691009285155e-17 1 TP53|P53-R-V 1.4717598558571e-22 0.567497153087539 1.73457411583158e-21 1 EGFR|EGFR_PY1068-R-V 3.36967667877001e-06 0.517735856733738 8.96768793543632e-06 1 RPS6|S6_PS235_S236-R-V 3.3812254970462e-09 0.480032069189172 1.21283088481005e-08 1 ERBB2|HER2-M-V 0.000566565437208704 0.474551802958758 0.00103870330154929 1 CHEK2|CHK2_PT68-R-C 8.3721194393766e-24 0.467020836497962 1.25581791590649e-22 1 ERBB2|HER2_PY1248-R-V 2.78221982268967e-05 0.447395898872752 6.28857905128487e-05 1 EGFR|EGFR-R-C 1.48068790438961e-08 0.430007249482091 4.88627008448571e-08 1 RPS6|S6-R-NA 5.72394103829105e-20 0.426910974702791 5.2469459517668e-19 1 CDH3|P-CADHERIN-R-C 7.82383774998922e-18 0.422552725411803 5.61275316847053e-17 1 MSH2|MSH2-M-C 6.83800849244662e-11 0.390067533092625 3.04938216555052e-10 1 SRC|SRC_PY416-R-C 1.83917320962311e-18 0.387185727577872 1.51731789793907e-17 1 RPS6|S6_PS240_S244-R-V 5.79401836884067e-09 0.363317466632442 1.99169381428898e-08 1 KIT|C-KIT-R-V 0.000444949827164499 0.34821840665196 0.000853682807931888 1 CHEK2|CHK2-M-C 7.31456971555533e-11 0.330760105541655 3.17606316596481e-10 1 PECAM1|CD31-M-V 1.86309825442827e-13 0.327173466715875 1.06003866200229e-12 1 LCK|LCK-R-V 2.77092443193423e-07 0.308477121687134 8.46671354202126e-07 1 CDC2|CDK1-R-V 1.93618680187551e-22 0.306400040135153 2.12980548206306e-21 1 WWTR1|TAZ_PS89-R-C 4.64251800194758e-12 0.294682400470632 2.25298667741574e-11 1 NFKB1|NF-KB-P65_PS536-R-C 7.53102020153488e-06 0.289228720794037 1.91172051269732e-05 1 CDKN1B|P27_PT198-R-V 4.75806533104766e-19 0.277427737186598 4.13200410327823e-18 1 AKT1 AKT2 AKT3|AKT_PT308-R-V 0.000934532287368326 0.25013555572859 0.00167377715178646 1 EIF4EBP1|4E-BP1_PS65-R-V 6.60549836076915e-18 0.241020351050127 4.95412377057686e-17 1 RB1|RB_PS807_S811-R-V 0.000314882250794381 0.239112382690627 0.000625970739530998 1 EIF4EBP1|4E-BP1_PT37-R-V 0.000494033374133672 0.230643515740295 0.000936959847494895 1 EGFR|EGFR_PY992-R-V 5.61410282193443e-07 0.222745119072525 1.62513502740207e-06 1 AKT1S1|PRAS40_PT246-R-V 1.04698035384147e-12 0.210595328898612 5.23490176920735e-12 1 AKT1 AKT2 AKT3|AKT_PS473-R-V 0.0250028751751719 0.209356998676134 0.0361186256169978 1 EEF2|EEF2-R-V 3.33340612156079e-15 0.198230990886172 2.11543080791358e-14 1 PTGS2|COX-2-R-C 0.00158079397082356 0.190889980953979 0.00266154086924375 1 SHC1|SHC_PY317-R-NA 7.5170090408864e-05 0.188265542327757 0.000157000821740032 1 SNAI2|SNAIL-M-C 1.09162966226883e-10 0.187900951468211 4.61843318652197e-10 1 ANXA1|ANNEXIN_I-R-V 0.0176662042697476 0.185256275292981 0.0260261045045389 1 TGM2|TRANSGLUTAMINASE-M-V 6.05400654492728e-08 0.181710201881117 1.9586491763e-07 1 NOTCH1|NOTCH1-R-V 7.76875296403464e-10 0.177448294718755 2.91328236151299e-09 1 YBX1|YB-1_PS102-R-V 1.68214306299306e-05 0.175418351160585 4.00649837308477e-05 1 EIF4EBP1|4E-BP1-R-V 0.00370000047509133 0.170488280201796 0.00604455523158485 1 MET|C-MET_PY1235-R-C 3.75887024265595e-10 0.163033865915188 1.47669902390055e-09 1 XRCC5|KU80-R-C 0.00128700895019444 0.151676198186475 0.00223533133454824 1 ATM|ATM-R-NA 0.0151949501514939 0.151491638522352 0.0225870880630315 1 GSK3A GSK3B|GSK3-ALPHA-BETA-M-V 0.0027568166324833 0.149048834684438 0.00459469438747217 1 CHEK1|CHK1_PS345-R-C 1.93178220312261e-11 0.144134550459693 9.1069732432923e-11 1 DVL3|DVL3-R-V 2.83473615939888e-05 0.139069305018537 6.32069549055156e-05 1 MRE11A|MRE11-R-C 4.21473851046294e-06 0.13881706218859 1.10386008607363e-05 1 ARAF|A-RAF_PS299-R-NA 4.5743964864599e-05 0.13470675114361 9.93125552981426e-05 1 PARP1|PARP_CLEAVED-M-C 6.48536598348791e-07 0.133634269002145 1.84497480564742e-06 1 EIF4EBP1|4E-BP1_PT170-R-V 1.68265753723379e-07 0.133153701896375 5.33920180083799e-07 1 VASP|VASP-R-C 0.00029641307361139 0.130127874097374 0.000596440940803407 1 CDKN1B|P27_PT157-R-C 1.35218353949467e-10 0.127602796226859 5.57775710041551e-10 1 STMN1|STATHMIN-R-V 3.30344431903417e-05 0.119557023240249 7.26757750187517e-05 1 CHEK1|CHK1-R-V 3.03008768100199e-06 0.113126467802954 8.19613880926768e-06 1 BECN1|BECLIN-G-V 7.40363358128451e-05 0.105601019803597 0.000156615325757942 1 MYC|C-MYC-R-C 0.00143048333799897 0.10270943693584 0.00243329639968897 1 ERCC1|ERCC1-M-C 3.17700267934531e-07 0.0968063648581058 9.36081146592815e-07 1 ANLN|ANLN-M-NA 7.42809982709784e-06 0.0947817650520575 1.91172051269732e-05 1 RAB25|RAB25-R-C 0.00780728780507576 0.0928149563559764 0.0122685951222619 1 BIRC2 |CIAP-R-V 0.00286333151458168 0.08954970829727 0.00472449699905977 1 SRC|SRC-M-V 0.0308740278409992 0.0778509091897539 0.043540295673204 1 YBX1|YB-1-R-V 0.024529030022547 0.0768148946526642 0.0358167252541615 1 JUN|C-JUN_PS73-R-C 0.00586913831356116 0.0761789331005911 0.0094941943307607 1 PRKCD|PKC-DELTA_PS664-R-V 0.000510693340012487 0.0727207353727058 0.000957550012523413 1 FOXO3|FOXO3A_PS318_S321-R-C 0.000373618117715479 0.0694157075554432 0.000725258699094753 1 NF2|NF2-R-C 0.0251735875512409 0.0613560662517082 0.0361186256169978 1 SETD2|SETD2-R-NA 0.0271709883998785 0.0560568139875908 0.038648388672241 1 RAD51|RAD51-M-C 0.011978863409125 0.0532600919259736 0.0183838591642007 1 RAF1|C-RAF_PS338-R-C 0.0395571248313665 0.0432211688768576 0.054391046643129 1 KRAS|K-RAS-M-C 0.0353935403947156 -0.0502345012300457 0.0494909675010854 1 BID|BID-R-C 0.0097939530634965 -0.06971881429776 0.0152453042969521 1 BCL2L1|BCL-XL-R-C 6.67904518528875e-05 -0.0697589168589638 0.000143122396827616 1 XRCC1|XRCC1-R-C 0.000366800495341473 -0.071039400235377 0.000720500972992179 1 CASP8|CASPASE-8-M-C 0.00753504278684109 -0.0715094006610902 0.0119546351906613 1 PIK3CA |PI3K-P110-ALPHA-R-C 0.037116045247533 -0.0752302429882645 0.0514634240827138 1 STAT3|STAT3_PY705-R-V 0.0120330714529314 -0.0850106484751356 0.0183838591642007 1 MET|C-MET-M-C 2.10420525372535e-05 -0.0876129982046757 4.82213703978726e-05 1 BAK1|BAK-R-C 0.000544808235954428 -0.0940851373625333 0.00101003774081439 1 EGFR|EGFR_PY1173-R-C 0.000921499715298372 -0.0962920975253854 0.00167085113213441 1 SMAD4|SMAD4-M-C 1.60865456242789e-05 -0.0973312895024665 3.90335298236179e-05 1 XIAP|XIAP-R-C 1.55031203186652e-05 -0.100627074828109 3.81793261579068e-05 1 YWHAE|14-3-3_EPSILON-M-C 2.98719395467006e-07 -0.109585892054202 8.96158186401018e-07 1 BCL2L1|BCL-X-R-C 1.18185951435399e-05 -0.111586973474308 2.95464878588497e-05 1 PRKAA1|AMPK_ALPHA-R-C 1.67213460428498e-06 -0.130172917507982 4.67630863910206e-06 1 MAPK14|P38_MAPK-R-C 1.69972658252081e-05 -0.134163285544903 4.00649837308477e-05 1 MAPT|TAU-M-C 0.0140276740422646 -0.147783928036768 0.0210415110633969 1 RBM3|RBM3-M-NA 0.00729619930290021 -0.148642939943377 0.0116880862619275 1 PTCH1|PTCH-R-C 0.000990966879262585 -0.151997630666299 0.00173946313913113 1 TSC2|TUBERIN-R-C 0.000943401667370552 -0.156878788630297 0.00167377715178646 1 PEA15|PEA-15-R-V 1.32858292254477e-08 -0.165750165103655 4.47379963714055e-08 1 DIABLO|SMAC-M-V 2.08069811318576e-05 -0.173027043099948 4.82213703978726e-05 1 RAD50|RAD50-M-C 1.9341743140731e-13 -0.177154786000337 1.0637958727402e-12 1 CLDN7|CLAUDIN-7-R-V 0.0408988661744198 -0.190075745381653 0.0557711811469361 1 ERBB3|HER3-M-C 2.4634784583695e-06 -0.200326609734994 6.77456576051612e-06 1 ACACA|ACC1-R-C 0.0133874671739221 -0.21231420371324 0.0202654319605243 1 RB1|RB-M-V 2.33028059816386e-11 -0.215366847888777 1.06804527415844e-10 1 PRKAA1|AMPK_PT172-R-V 0.000270866012987112 -0.219138848121396 0.000551764100529302 1 TP53BP1|53BP1-R-C 0.000110957354923031 -0.220780360326593 0.000228849544528751 1 CDKN1B|P27-R-V 1.86346900983787e-07 -0.222439373986273 5.80136578534431e-07 1 IRS1|IRS1-R-V 1.75108329578229e-15 -0.225413088485829 1.15571497521631e-14 1 PDK1|PDK1_PS241-R-V 3.28164400204688e-10 -0.230731433024389 1.32066161057984e-09 1 SMAD3|SMAD3-R-V 2.03247544627861e-28 -0.255168732266262 4.19198060794963e-27 1 EEF2K|EEF2K-R-V 1.71030530456172e-09 -0.29388024108567 6.27111945005964e-09 1 MAPK9|JNK2-R-C 1.82575359643135e-23 -0.368750173029874 2.51041119509311e-22 1 BCL2L11|BIM-R-V 8.3028439983349e-14 -0.377593450217667 4.89274735616164e-13 1 MAPK1 MAPK3|MAPK_PT202_Y204-R-V 0.00136327398405715 -0.39431452590952 0.00234312716009823 1 PARK7|DJ-1-R-C 2.75157215922529e-20 -0.402050494031529 2.83755878920108e-19 1 KDR|VEGFR2-R-C 7.64293223856819e-10 -0.44395356321828 2.91328236151299e-09 1 CCND1|CYCLIN_D1-R-V 3.03777529722846e-20 -0.473601183234642 2.94842896495703e-19 1 ESR1|ER-ALPHA_PS118-R-V 3.5664211120795e-36 -0.568171370960168 1.47114870873279e-34 1 IGFBP2|IGFBP2-R-V 3.90165946336808e-09 -0.671319555642032 1.3697315137356e-08 1 INPP4B|INPP4B-G-C 9.1756114410494e-33 -0.781749518578852 3.0279517755463e-31 1 COL6A1|COLLAGEN_VI-R-V 2.27140978020794e-13 -0.820886047622331 1.20897617333648e-12 1 IGF1R|IGF-1R-BETA-R-C 6.16868010283643e-25 -0.873920238949383 1.13092468552001e-23 1 AR|AR-R-V 1.0366972367562e-22 -1.00011815885072 1.31580803126748e-21 1 BCL2|BCL-2-M-V 6.23703668428316e-31 -1.2245994220607 1.71518508817787e-29 1 CAV1|CAVEOLIN-1-R-V 5.20656836582158e-24 -1.2362019885362 8.5908378036056e-23 1 GATA3|GATA3-M-V 5.48787148572987e-45 -1.66002787996654 3.01832931715143e-43 1 PGR|PR-R-V 5.82856984709965e-59 -2.77686302251301 4.80857012385721e-57 1 ESR1|ER-ALPHA-R-V 9.29545334791005e-86 -3.9635057873754 1.53374980240516e-83 1 ESR1|ER-ALPHA-R-V 3.28728258103331e-73 3.49179222576213 5.42401625870496e-71 2 PGR|PR-R-V 3.07651438338611e-26 2.39202935801722 6.34531091573385e-25 2 GATA3|GATA3-M-V 1.98124144884522e-57 1.63356491234949 1.63452419529731e-55 2 AR|AR-R-V 6.13473958647702e-28 0.931954453752918 1.44604575966958e-26 2 IGF1R|IGF-1R-BETA-R-C 1.74328155676949e-22 0.882849582286213 1.91760971244644e-21 2 BCL2|BCL-2-M-V 4.42196786603883e-17 0.863772592293707 2.28007718092627e-16 2 INPP4B|INPP4B-G-C 4.94989372997849e-30 0.85725869568238 1.6334649308929e-28 2 CLDN7|CLAUDIN-7-R-V 2.26811814220438e-18 0.811309460104405 1.43938266716816e-17 2 ESR1|ER-ALPHA_PS118-R-V 2.56262866050611e-39 0.796533743083638 1.40944576327836e-37 2 CDH1|E-CADHERIN-R-V 2.16797217741216e-13 0.75108482577254 8.1298956652956e-13 2 KDR|VEGFR2-R-C 7.75742492017116e-23 0.746355696517906 9.84596239867878e-22 2 FRAP1|MTOR-R-V 9.04519233126358e-29 0.643319660988158 2.48742789109748e-27 2 BRAF|B-RAF-M-NA 5.95593185537029e-22 0.614534063767563 5.78075738903587e-21 2 IGFBP2|IGFBP2-R-V 2.40310070779438e-09 0.596307663489359 6.29383518708052e-09 2 TP53BP1|53BP1-R-C 2.59680559729392e-19 0.51085231853278 1.71389169421399e-18 2 ACACA|ACC1-R-C 1.5569722350286e-09 0.50456473692746 4.14355514160837e-09 2 CTNNB1|BETA-CATENIN-R-V 5.08165600704928e-11 0.472358195636785 1.55272822437617e-10 2 EEF2K|EEF2K-R-V 3.88315037426303e-22 0.45057662725286 4.00449882345875e-21 2 BCL2L11|BIM-R-V 1.61696814868637e-14 0.410410760884783 6.84101909059618e-14 2 TSC2|TUBERIN-R-C 1.01954253689989e-20 0.386508690489817 8.01069136135628e-20 2 ACACA ACACB|ACC_PS79-R-V 1.51361360173476e-06 0.377782802026945 3.24345771800306e-06 2 RPS6KB1|P70S6K-R-V 2.7103359730762e-08 0.35893708885881 6.57655052290548e-08 2 RBM3|RBM3-M-NA 5.96745812908717e-11 0.34528645419508 1.79023743872615e-10 2 PDK1|PDK1_PS241-R-V 1.78924671271209e-19 0.321184402818021 1.28359003303259e-18 2 GSK3A GSK3B|GSK3-ALPHA-BETA-M-V 1.89143901621194e-10 0.30071525676333 5.38081789094776e-10 2 DIABLO|SMAC-M-V 6.42313528705526e-14 0.294700850046224 2.58492029844907e-13 2 CTNNA1|ALPHA-CATENIN-M-V 7.91762506579394e-16 0.284251414672712 3.95881253289697e-15 2 BIRC2 |CIAP-R-V 4.16507604790285e-21 0.278962900177517 3.61703972581037e-20 2 XRCC5|KU80-R-C 3.22619877489518e-11 0.264727637076945 1.04642971669427e-10 2 MAPK9|JNK2-R-C 6.91992597086897e-13 0.261065627129348 2.53730618931862e-12 2 GAB2|GAB2-R-V 0.00063419677419416 0.260295766433009 0.00102158218566388 2 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9-R-V 0.000641973089245292 0.256798349893364 0.00102158218566388 2 RB1|RB_PS807_S811-R-V 7.57449342541669e-05 0.256290067489474 0.000138865712799306 2 AKT1 AKT2 AKT3|AKT-R-V 3.67131806411363e-07 0.24316928731516 8.18604703484796e-07 2 STAT5A|STAT5-ALPHA-R-V 0.000643906347327538 0.239720251462757 0.00102158218566388 2 PRKAA1|AMPK_PT172-R-V 0.000158788262741212 0.225007133585297 0.000267347585227551 2 RAF1|C-RAF-R-V 2.86694783667357e-14 0.223134962997597 1.18261598262785e-13 2 NCOA3|AIB1-M-V 3.69159171305201e-12 0.212555414772883 1.26898465136163e-11 2 RPS6|S6-R-NA 8.71093777084462e-05 0.187915825877574 0.00015454889593434 2 PTEN|PTEN-R-V 0.000125127499491629 0.186911919471053 0.000217326709643356 2 PARK7|DJ-1-R-C 0.00010377460746688 0.170951419200343 0.000182157555659949 2 MSH2|MSH2-M-C 0.000688272993139685 0.167534159808638 0.00108157184636236 2 PECAM1|CD31-M-V 0.001152107243154 0.158909539195824 0.00179337448226802 2 DVL3|DVL3-R-V 7.98346578763167e-07 0.151231403781922 1.73325244073582e-06 2 MAPT|TAU-M-C 0.00899916797442315 0.149641161683982 0.0122715926923952 2 IRS1|IRS1-R-V 3.43388020685987e-06 0.147365456063501 7.26397736066511e-06 2 STK11|LBK1-M-NA 8.47901668785327e-15 0.14645762312786 3.88621598193275e-14 2 BECN1|BECLIN-G-V 1.08305493072738e-07 0.144547588194622 2.5529151938574e-07 2 SMAD3|SMAD3-R-V 5.97686094219571e-09 0.143804844587014 1.49421523554893e-08 2 MAPK1|ERK2-R-NA 0.00355054780478221 0.143715654552975 0.00513895077007951 2 RPS6KA1|P90RSK_PT359_S363-R-C 6.11326660699406e-05 0.139243697002574 0.000114623748881139 2 MSH6|MSH6-R-C 0.0342680874316281 0.134749959782609 0.0431620948566308 2 ATM|ATM-R-NA 0.0194035760921671 0.133825138602632 0.0250124223063092 2 RAD50|RAD50-M-C 2.82414651423241e-07 0.125409289978146 6.47200242844927e-07 2 CHEK2|CHK2-M-C 0.00739184719775384 0.121317344373856 0.0102491998960452 2 PIK3CA |PI3K-P110-ALPHA-R-C 1.33544977923483e-05 0.118680081712185 2.65480980209334e-05 2 NF2|NF2-R-C 2.34578449892866e-05 0.118314319050687 4.5006330502701e-05 2 XRCC1|XRCC1-R-C 3.93844705655316e-09 0.10923246117151 1.01538088176761e-08 2 PRKCD|PKC-DELTA_PS664-R-V 3.6649212905927e-07 0.104065845917677 8.18604703484796e-07 2 PRKAA1|AMPK_ALPHA-R-C 0.00133321155145744 0.100453035731579 0.00205588697187362 2 YBX1|YB-1-R-V 0.00490358795121661 0.0909033406666476 0.00686365873348923 2 ERCC1|ERCC1-M-C 1.75337169782588e-05 0.0820340391056065 3.44412297787226e-05 2 MAP2K1|MEK1_PS217_S221-R-V 0.00870775311214958 0.0784089456874142 0.0119731605292057 2 MAPK14|P38_MAPK-R-C 0.0157945484322814 0.0761208917641305 0.0206833372327495 2 CDKN1B|P27_PT157-R-C 0.000144486822536987 0.0733352529419338 0.000245776553800029 2 ARAF|A-RAF_PS299-R-NA 0.0171824313004445 0.0697160421310641 0.0223236312171129 2 EEF2|EEF2-R-V 0.0151582741432106 0.0635565454323226 0.020008921869038 2 XIAP|XIAP-R-C 0.00293575863015939 0.0615206768366705 0.00432500155335982 2 RAF1|C-RAF_PS338-R-C 0.00258529504458707 -0.0599103211486842 0.00384300614735916 2 FOXO3|FOXO3A_PS318_S321-R-C 0.00191491702897565 -0.0605388522784898 0.00289872761266956 2 CDKN1A|P21-R-C 0.0271270240976171 -0.0619769934974828 0.0344304536623602 2 ERRFI1|MIG-6-M-V 0.00396485812742851 -0.065519742135984 0.00566785437995745 2 MYC|C-MYC-R-C 0.0132627969900071 -0.0719873211800343 0.0176480766399288 2 EIF4EBP1|4E-BP1_PS65-R-V 0.00490855594273775 -0.0789938512124715 0.00686365873348923 2 SETD2|SETD2-R-NA 0.00242983790638026 -0.0795652274429062 0.00364475685957039 2 BAX|BAX-R-V 0.0129536834138185 -0.0805785949138444 0.0173768923843907 2 ERBB3|HER3-M-C 0.0464217624262628 -0.080581332632151 0.0580272030328285 2 BCL2L1|BCL-X-R-C 5.08157682281862e-06 -0.11038459428484 1.06134199463933e-05 2 SNAI2|SNAIL-M-C 4.97333552891202e-05 -0.11040127448032 9.43218807207452e-05 2 PCNA|PCNA-M-V 2.1203606066701e-05 -0.112282768356579 4.11599411883019e-05 2 CDC2|CDK1-R-V 0.000143252927520128 -0.115400268988272 0.000245776553800029 2 MAP2K1|MEK1-R-V 0.00398467338227312 -0.115447741927117 0.00566785437995745 2 RPS6KB1|P70S6K_PT389-R-V 8.67804394432935e-05 -0.120838950713101 0.00015454889593434 2 YWHAE|14-3-3_EPSILON-M-C 1.4878664549619e-09 -0.124914780576144 4.02455680440514e-09 2 STAT3|STAT3_PY705-R-V 8.6130961369742e-05 -0.13798819215492 0.00015454889593434 2 YBX1|YB-1_PS102-R-V 0.000230240506581331 -0.13962171715206 0.000383734177635552 2 SRC|SRC-M-V 7.37586944417003e-06 -0.143026441431293 1.50249192381241e-05 2 SMAD4|SMAD4-M-C 8.02480747190533e-11 -0.147115986036556 2.32490194446361e-10 2 FOXO3|FOXO3A-R-C 5.05097297984248e-08 -0.151061521566762 1.20784136474494e-07 2 MET|C-MET-M-C 8.60427938529913e-14 -0.152425775870824 3.38025261565323e-13 2 RAD51|RAD51-M-C 4.68096195842461e-15 -0.15381677137889 2.2067392089716e-14 2 PTCH1|PTCH-R-C 0.000543375841734518 -0.154656341983066 0.000887693206794015 2 VASP|VASP-R-C 2.18265889905365e-07 -0.158892958857723 5.07237631470214e-07 2 SYK|SYK-M-V 0.0204165115829344 -0.160521461246453 0.026114142722358 2 CHEK1|CHK1-R-V 1.22802763868552e-17 -0.163740680054405 6.75415201277036e-17 2 CASP8|CASPASE-8-M-C 2.88990489558814e-12 -0.174935538069165 1.01454108036605e-11 2 YAP1|YAP-R-V 8.03147944451064e-11 -0.187534585510755 2.32490194446361e-10 2 MAPK14|P38_PT180_Y182-R-V 0.00165526513124545 -0.189428703856522 0.00252887728384721 2 RPS6|S6_PS235_S236-R-V 0.0126599687863609 -0.189717664106694 0.0171220889323733 2 PRKCA |PKC-ALPHA-M-V 1.11832077477494e-17 -0.190795096348455 6.36285958061604e-17 2 STMN1|STATHMIN-R-V 8.09812810622762e-13 -0.197559412611499 2.90476334245121e-12 2 EGFR|EGFR_PY992-R-V 3.72369545308481e-07 -0.205093133170366 8.19212999678658e-07 2 NOTCH1|NOTCH1-R-V 1.94782037403153e-19 -0.209091474412586 1.33912650714668e-18 2 YAP1|YAP_PS127-R-C 0.000377144746733861 -0.209730922838158 0.00062228883211087 2 KRAS|K-RAS-M-C 1.12222590793291e-20 -0.217092915018249 8.41669430949683e-20 2 BID|BID-R-C 1.28552550798819e-17 -0.217101255912815 6.84231318767908e-17 2 EGFR|EGFR_PY1173-R-C 6.98366469918642e-18 -0.218703900938044 4.26779509394726e-17 2 ERBB3|HER3_PY1298-R-V 1.11239894095895e-13 -0.229179980386041 4.26850756414481e-13 2 PRKCA |PKC-ALPHA_PS657-R-V 4.3126260647127e-09 -0.234247994486384 1.09474353950399e-08 2 CASP9|CASPASE-9_CLEAVEDD330-R-C 8.95669739451896e-18 -0.238184399991419 5.2780538217701e-17 2 RB1|RB-M-V 3.516467392817e-15 -0.244187706447426 1.70652094063178e-14 2 BAK1|BAK-R-C 5.39184960715416e-21 -0.250937508075114 4.44827592590218e-20 2 CDH2|N-CADHERIN-R-V 1.50637664878877e-22 -0.263454410840561 1.77537247892962e-21 2 ERBB2|HER2_PY1248-R-V 7.29488219746871e-05 -0.26391492786167 0.000135242198042959 2 PTGS2|COX-2-R-C 3.39493926202382e-10 -0.268680658522826 9.3360829705655e-10 2 AKT1 AKT2 AKT3|AKT_PT308-R-V 5.68875634533698e-06 -0.295135291331579 1.17330599622575e-05 2 CCNE1|CYCLIN_E1-M-V 1.69883860148986e-11 -0.327396855549485 5.72057896420055e-11 2 FN1|FIBRONECTIN-R-C 0.00321676741252005 -0.335785107393993 0.00469704976164432 2 PTK2|FAK-R-C 4.17534102441176e-11 -0.355217881977117 1.29987031892064e-10 2 SRC|SRC_PY527-R-V 2.66788671931192e-10 -0.371939991970595 7.4610391302791e-10 2 CDH3|P-CADHERIN-R-C 7.80178418240397e-24 -0.378758856094966 1.1702676273606e-22 2 AKT1 AKT2 AKT3|AKT_PS473-R-V 8.84164229246464e-06 -0.379722474498913 1.77911094909349e-05 2 NOTCH3|NOTCH3-R-C 1.27701009154057e-14 -0.407728815742735 5.54491223958405e-14 2 EGFR|EGFR_PY1068-R-V 3.23441912432775e-11 -0.460887504887128 1.04642971669427e-10 2 CASP7|CASPASE-7_CLEAVEDD198-R-C 3.43345015353908e-11 -0.46722699347214 1.08946014487298e-10 2 LCK|LCK-R-V 3.18155311977553e-23 -0.503372330210641 4.37463553969135e-22 2 EGFR|EGFR-R-C 1.86115353405633e-24 -0.517668643335069 3.07090333119294e-23 2 CAV1|CAVEOLIN-1-R-V 1.10999059796616e-08 -0.703694442442448 2.7335589352898e-08 2 KIT|C-KIT-R-V 1.82738092264714e-24 -0.736061824807609 3.07090333119294e-23 2 ANXA1|ANNEXIN_I-R-V 2.71435229157102e-30 -0.81547017849651 1.11967032027305e-28 2 COL6A1|COLLAGEN_VI-R-V 9.5154355744017e-15 -0.894361045278947 4.24336991831427e-14 2 HSPA1A|HSP70-R-C 3.77876027419003e-21 -0.901866740371453 3.46386358467419e-20 2 CAV1|CAVEOLIN-1-R-V 1.48682221362322e-48 2.28840005664508 1.22662832623916e-46 3 COL6A1|COLLAGEN_VI-R-V 1.82319034933883e-33 2.04566858388365 7.52066019102267e-32 3 HSPA1A|HSP70-R-C 2.8222395839339e-15 1.03264832198249 1.3696162686738e-14 3 ANXA1|ANNEXIN_I-R-V 7.66522819474644e-26 0.79146712178926 1.26476265213316e-24 3 NOTCH3|NOTCH3-R-C 4.41883957442164e-14 0.570452713450055 2.02530147160992e-13 3 CCND1|CYCLIN_D1-R-V 1.22452744371565e-21 0.560898721495895 1.26279392633176e-20 3 RB1|RB-M-V 3.76486533010028e-29 0.54845601042768 1.03533796577758e-27 3 PTK2|FAK-R-C 2.61082006172158e-12 0.537772488423206 8.79153694253185e-12 3 FN1|FIBRONECTIN-R-C 2.0903843033839e-05 0.528544885095909 3.91947056884481e-05 3 SRC|SRC_PY527-R-V 8.98261498694497e-17 0.519874263175117 5.29332668873543e-16 3 KIT|C-KIT-R-V 5.42536740068237e-11 0.506251268714069 1.6577511502085e-10 3 MAPK1 MAPK3|MAPK_PT202_Y204-R-V 3.85852133912701e-05 0.499431772032663 6.99622001050502e-05 3 BAK1|BAK-R-C 1.89691623028286e-22 0.417301430901202 2.2356512714048e-21 3 EGFR|EGFR_PY1173-R-C 7.4112936205427e-21 0.380133665611853 6.7936858188308e-20 3 CDH2|N-CADHERIN-R-V 1.33673158207546e-19 0.369777302238046 1.10280355521225e-18 3 PTCH1|PTCH-R-C 5.50993332276461e-14 0.365298347055565 2.45713242771935e-13 3 BID|BID-R-C 1.83654958836159e-17 0.347601312460731 1.16550262338332e-16 3 BCL2|BCL-2-M-V 0.000326510327866274 0.344235985737183 0.000538742040979352 3 ERBB3|HER3-M-C 6.30901753437369e-09 0.329628376404672 1.53086454878185e-08 3 KRAS|K-RAS-M-C 8.96017351232054e-17 0.325184867541066 5.29332668873543e-16 3 CASP9|CASPASE-9_CLEAVEDD330-R-C 1.34322594980904e-16 0.315764914773546 7.38774272394972e-16 3 CASP8|CASPASE-8-M-C 5.87203825273106e-21 0.297720260747472 5.69933124529779e-20 3 SMAD4|SMAD4-M-C 2.52910669761713e-20 0.293145983838836 2.19632950056224e-19 3 MET|C-MET-M-C 6.29435645960808e-16 0.288510994920898 3.14717822980404e-15 3 YWHAE|14-3-3_EPSILON-M-C 5.27173887182967e-22 0.279890613012755 5.79891275901264e-21 3 STAT3|STAT3_PY705-R-V 2.81412705146096e-07 0.267734037983827 6.19107951321411e-07 3 LCK|LCK-R-V 6.14170572590696e-07 0.265322886567105 1.25108820342549e-06 3 BCL2L1|BCL-X-R-C 1.20675053779527e-13 0.264293346586766 5.23983786147946e-13 3 YAP1|YAP_PS127-R-C 1.58670448328112e-05 0.261927771974666 3.08007340872217e-05 3 PARK7|DJ-1-R-C 3.55984921399573e-07 0.251762106989289 7.62824831570514e-07 3 ERBB3|HER3_PY1298-R-V 5.155289991392e-08 0.24932899277129 1.18142062302733e-07 3 PEA15|PEA-15-R-V 5.23857334486507e-09 0.229506274505056 1.30964333621627e-08 3 AKT1 AKT2 AKT3|AKT_PS473-R-V 0.00935318864926374 0.226993881212395 0.0131903942489617 3 MAP2K1|MEK1-R-V 3.47415640922034e-07 0.222497011741341 7.54257641475468e-07 3 PRKCA |PKC-ALPHA-M-V 3.17641038546145e-13 0.21225750777795 1.21885514790963e-12 3 YAP1|YAP-R-V 5.81655586668674e-08 0.208939846101653 1.31470098356618e-07 3 MAPK14|P38_PT180_Y182-R-V 0.000721663247389382 0.207504624509284 0.00111284519457241 3 PRKCA |PKC-ALPHA_PS657-R-V 4.1047264509352e-07 0.196697419134315 8.57316284056086e-07 3 FOXO3|FOXO3A-R-C 8.09005004307673e-10 0.18524222919883 2.18829222476666e-09 3 RPS6KB1|P70S6K_PT389-R-V 0.000354112849320988 0.179168842176456 0.000572829609195716 3 BAX|BAX-R-V 0.000510499379538366 0.160447744031817 0.000809926900229138 3 CDKN1B|P27-R-V 9.9265369737217e-05 0.155521104536204 0.000172408273754114 3 PCNA|PCNA-M-V 8.94003358460881e-07 0.143572219173214 1.79890919690299e-06 3 EGFR|EGFR-R-C 0.00652607655233631 0.143178505677989 0.00936350114030862 3 RAD51|RAD51-M-C 1.97716497347533e-05 0.128226091653501 3.74979563934976e-05 3 SMAD3|SMAD3-R-V 1.70789119786014e-05 0.116293455065431 3.27676799589445e-05 3 PTGS2|COX-2-R-C 0.0137527024322992 0.111447782444699 0.0184487471652794 3 STMN1|STATHMIN-R-V 0.0248900518443943 0.105869930495966 0.0323374689316934 3 MAPK9|JNK2-R-C 0.0125272846146483 0.102464503461259 0.0169426390280079 3 SRC|SRC-M-V 0.00788674743349342 0.0866560117406716 0.0112182183321243 3 IRS1|IRS1-R-V 0.0122522090777649 0.0776896735468095 0.0167075578333158 3 CDKN1A|P21-R-C 0.0158037224495359 0.0724890327317924 0.0208609136333874 3 CHEK1|CHK1-R-V 0.0104256436912071 0.0716065552664459 0.0145782305851625 3 ERRFI1|MIG-6-M-V 0.011145562170445 0.0576644453856101 0.0153251479843619 3 BCL2L1|BCL-XL-R-C 0.0477013106343347 0.0550251094761989 0.0605439711897325 3 XRCC1|XRCC1-R-C 0.0198928391872718 -0.0528612077472252 0.0260501465547607 3 PRDX1|PRDX1-R-NA 0.0141768020633434 -0.102659625720729 0.0188642930681586 3 MAP2K1|MEK1_PS217_S221-R-V 0.00389567671841941 -0.105744108917832 0.00579087079765047 3 PARP1|PARP_CLEAVED-M-C 0.010793189855644 -0.117801841209295 0.0149653472788341 3 EIF4EBP1|4E-BP1_PT170-R-V 0.00017100349223433 -0.119394066281245 0.000287914043047596 3 MAPK1|ERK2-R-NA 0.0458258938579818 -0.125750570072408 0.0586145153997442 3 PDK1|PDK1_PS241-R-V 0.0042384875630629 -0.130306364923752 0.00618894201686176 3 CHEK1|CHK1_PS345-R-C 8.85232353442499e-05 -0.148211685556992 0.000155386530125545 3 STK11|LBK1-M-NA 4.28594858184342e-09 -0.156211634068602 1.10497111875651e-08 3 INPP4B|INPP4B-G-C 0.0400711636394902 -0.156999575885205 0.0516542343790303 3 MET|C-MET_PY1235-R-C 0.00147909605053606 -0.158158420277087 0.00225973007720787 3 PTEN|PTEN-R-V 0.00534513636947911 -0.159149909269899 0.00773638158740397 3 DIABLO|SMAC-M-V 0.000577621091460455 -0.164041369647405 0.000907690286580715 3 MRE11A|MRE11-R-C 0.00407699689207029 -0.164891428233713 0.0060062900642107 3 EIF4EBP1|4E-BP1_PS65-R-V 8.95452628965204e-08 -0.179858220599521 1.99661734836836e-07 3 ERBB2|HER2_PY1248-R-V 0.00270456548958545 -0.189394104276312 0.00405684823437817 3 EIF4EBP1|4E-BP1-R-V 0.00172061589084091 -0.200165439294669 0.00260460203659404 3 YBX1|YB-1-R-V 2.25397498927104e-05 -0.200309661621684 4.17871767673845e-05 3 CDC2|CDK1-R-V 5.30839792976219e-07 -0.210196423877277 1.09485707301345e-06 3 PRKCD|PKC-DELTA_PS664-R-V 2.56984642227611e-10 -0.211815250119481 7.31076999440617e-10 3 ERCC1|ERCC1-M-C 2.16099443106834e-11 -0.21237374782446 7.04264449946734e-11 3 TGM2|TRANSGLUTAMINASE-M-V 1.34940670185623e-10 -0.214777614765301 3.93129732729849e-10 3 NF2|NF2-R-C 1.35808453124857e-10 -0.216297753013248 3.93129732729849e-10 3 EEF2K|EEF2K-R-V 0.000208132275283107 -0.2170744322063 0.000346887125471845 3 AKT1 AKT2 AKT3|AKT-R-V 0.000100843551620543 -0.227852810311018 0.000173324854347808 3 CASP7|CASPASE-7_CLEAVEDD198-R-C 0.000366875346814403 -0.228650781510623 0.000587712934217248 3 RPS6KA1|P90RSK_PT359_S363-R-C 6.84543473241427e-10 -0.231382092475741 1.88249455141392e-09 3 CDKN1B|P27_PT157-R-C 5.6779227274807e-11 -0.237073144121278 1.70337681824421e-10 3 ARAF|A-RAF_PS299-R-NA 4.38286455301953e-13 -0.240784224304147 1.64357420738232e-12 3 RBM3|RBM3-M-NA 7.18474613826653e-05 -0.254393953973715 0.000127471302453116 3 AKT1S1|PRAS40_PT246-R-V 1.80787999864134e-13 -0.256191184231493 7.45750499439553e-13 3 CCNE1|CYCLIN_E1-M-V 4.95280197417873e-08 -0.27144160962119 1.15100327568942e-07 3 SHC1|SHC_PY317-R-NA 0.000653307644334246 -0.273602220303901 0.00101694114448255 3 WWTR1|TAZ_PS89-R-C 5.01070837806202e-18 -0.273732880661781 3.44486200991764e-17 3 STAT5A|STAT5-ALPHA-R-V 0.000165057379036435 -0.274430565342729 0.000280767706608369 3 RAF1|C-RAF-R-V 2.26190917248983e-13 -0.280565277327402 9.10280520636151e-13 3 TSC2|TUBERIN-R-C 3.25507182788282e-08 -0.29570102515757 7.67266930858093e-08 3 CDKN1B|P27_PT198-R-V 3.27182994695147e-16 -0.298226385344244 1.68703731639685e-15 3 BECN1|BECLIN-G-V 5.45839558674146e-09 -0.29949206041415 1.34423174897364e-08 3 EEF2|EEF2-R-V 9.77308251869688e-17 -0.306247196288573 5.56054695029305e-16 3 NCOA3|AIB1-M-V 7.18644386607264e-19 -0.308760579308375 5.38983289955448e-18 3 RPS6|S6_PS235_S236-R-V 0.000338111890243118 -0.318321310206018 0.000552361008813014 3 RPS6|S6_PS240_S244-R-V 1.7169066395573e-06 -0.320505833508862 3.3724951848447e-06 3 ESR1|ER-ALPHA_PS118-R-V 2.55248643805401e-12 -0.32780418675089 8.77417213081066e-12 3 ACACA ACACB|ACC_PS79-R-V 4.53989217386918e-05 -0.334513962808041 8.14219792052625e-05 3 ATM|ATM-R-NA 2.57005034493974e-08 -0.339056391670554 6.14577256398633e-08 3 DVL3|DVL3-R-V 2.82601963052487e-13 -0.346212423244636 1.1102219977062e-12 3 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9-R-V 3.7019035035056e-07 -0.362011224233254 7.83094971895415e-07 3 TP53BP1|53BP1-R-C 2.77823068617015e-10 -0.37538453317103 7.76962819013686e-10 3 ACACA|ACC1-R-C 3.41693634564714e-05 -0.377375164243508 6.26438330035309e-05 3 GAB2|GAB2-R-V 4.60205077154104e-09 -0.390919035512914 1.16821288816042e-08 3 NFKB1|NF-KB-P65_PS536-R-C 9.97630039162754e-10 -0.391468759578626 2.61284057875959e-09 3 KDR|VEGFR2-R-C 9.17305630696658e-07 -0.408839812110602 1.82355938632468e-06 3 CTNNA1|ALPHA-CATENIN-M-V 2.37819766170773e-11 -0.410706620858497 7.5462041188803e-11 3 BIRC2 |CIAP-R-V 6.51535062575692e-24 -0.446607829882809 8.27755177645814e-23 3 RPS6KB1|P70S6K-R-V 3.73981499116694e-11 -0.493723453252986 1.16428202555197e-10 3 XRCC5|KU80-R-C 2.61189714239043e-25 -0.500515636250379 3.91784571358565e-24 3 SRC|SRC_PY416-R-C 1.93325177493965e-12 -0.505056589241006 6.78694772053281e-12 3 CHEK2|CHK2-M-C 6.52170746023975e-24 -0.529800638591769 8.27755177645814e-23 3 SYK|SYK-M-V 2.17681739074445e-11 -0.534008788553892 7.04264449946734e-11 3 GSK3A GSK3B|GSK3-ALPHA-BETA-M-V 4.44946220086733e-18 -0.541824184984391 3.19200549192656e-17 3 PECAM1|CD31-M-V 9.92409900202235e-10 -0.571982591293189 2.61284057875959e-09 3 RB1|RB_PS807_S811-R-V 7.43049918187452e-18 -0.590670222800676 4.90412946003718e-17 3 ERBB2|HER2-M-V 3.96223148937303e-15 -0.615591271305063 1.86790913070443e-14 3 CTNNB1|BETA-CATENIN-R-V 5.35559007101927e-19 -0.615973877840668 4.20796362722943e-18 3 CHEK2|CHK2_PT68-R-C 6.30363312088125e-13 -0.624346690888975 2.31133214432312e-12 3 MSH2|MSH2-M-C 7.86516787271826e-39 -0.654932113190303 4.32584232999504e-37 3 FRAP1|MTOR-R-V 3.32525838056512e-28 -0.698565367384694 6.09630703103605e-27 3 BRAF|B-RAF-M-NA 5.42454447570535e-29 -0.717285944147105 1.27864262641626e-27 3 TP53|P53-R-V 1.26315245418043e-13 -0.718717412844931 5.3441065369172e-13 3 RPS6|S6-R-NA 6.55700770275863e-29 -0.722406918503752 1.35238283869397e-27 3 CLDN7|CLAUDIN-7-R-V 1.53778752735573e-16 -0.78079971189278 8.18499812947405e-16 3 MSH6|MSH6-R-C 1.40909001544813e-57 -0.872795721370459 2.32499852548941e-55 3 CDH1|E-CADHERIN-R-V 7.80304068573796e-13 -0.898753116146824 2.79891676771036e-12 3 CCNB1|CYCLIN_B1-R-V 1.78177950615723e-29 -1.14849603085536 5.87987237031886e-28 3