Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.099 0.254 -9999.0 0.0 -0.674 64.0 64.0 IHH -0.013 0.093 -9999.0 0.0 -0.551 11.0 11.0 SHH Np/Cholesterol/GAS1 -0.057 0.141 -9999.0 0.0 -0.29 133.0 133.0 LRPAP1 0.016 0.026 -9999.0 0.0 -0.39 2.0 2.0 dorsoventral neural tube patterning 0.056 0.14 0.288 133.0 -9999.0 0.0 133.0 SMO/beta Arrestin2 -0.053 0.169 -9999.0 0.0 -0.51 35.0 35.0 SMO -0.064 0.177 -9999.0 0.0 -0.542 35.0 35.0 AKT1 -0.027 0.134 -9999.0 0.0 -0.526 20.0 20.0 ARRB2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.018 0.12 -9999.0 0.0 -0.379 48.0 48.0 ADRBK1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.063 0.175 -9999.0 0.0 -0.525 37.0 37.0 STIL -0.052 0.148 -9999.0 0.0 -0.374 51.0 51.0 DHH N/PTCH2 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.027 0.126 -9999.0 0.0 -0.384 18.0 18.0 PIK3CA 0.016 0.029 -9999.0 0.0 -0.346 3.0 3.0 DHH 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.119 0.308 -9999.0 0.0 -0.832 64.0 64.0 determination of left/right symmetry -0.063 0.175 -9999.0 0.0 -0.525 37.0 37.0 PIK3R1 -0.009 0.109 -9999.0 0.0 -0.422 32.0 32.0 skeletal system development -0.117 0.304 -9999.0 0.0 -0.821 64.0 64.0 IHH N/Hhip 0.004 0.069 -9999.0 0.0 -0.316 18.0 18.0 DHH N/Hhip 0.021 0.037 -9999.0 0.0 -0.369 3.0 3.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.063 0.175 -9999.0 0.0 -0.525 37.0 37.0 pancreas development 0.01 0.052 -9999.0 0.0 -0.329 11.0 11.0 HHAT -0.045 0.172 -9999.0 0.0 -0.509 63.0 63.0 PI3K 0.006 0.082 -9999.0 0.0 -0.369 21.0 21.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.072 0.194 -9999.0 0.0 -0.467 98.0 98.0 somite specification -0.063 0.175 -9999.0 0.0 -0.525 37.0 37.0 SHH Np/Cholesterol/PTCH1 -0.048 0.143 -9999.0 0.0 -0.384 37.0 37.0 SHH Np/Cholesterol/PTCH2 -0.007 0.098 -9999.0 0.0 -0.275 61.0 61.0 SHH Np/Cholesterol/Megalin -0.102 0.182 -9999.0 0.0 -0.333 181.0 181.0 SHH -0.021 0.126 -9999.0 0.0 -0.369 61.0 61.0 catabolic process -0.042 0.141 -9999.0 0.0 -0.421 23.0 23.0 SMO/Vitamin D3 -0.06 0.165 -9999.0 0.0 -0.459 37.0 37.0 SHH Np/Cholesterol/Hhip -0.01 0.101 -9999.0 0.0 -0.277 64.0 64.0 LRP2 -0.156 0.245 -9999.0 0.0 -0.484 183.0 183.0 receptor-mediated endocytosis -0.119 0.197 -9999.0 0.0 -0.495 71.0 71.0 SHH Np/Cholesterol/BOC -0.026 0.115 -9999.0 0.0 -0.283 83.0 83.0 SHH Np/Cholesterol/CDO -0.019 0.112 -9999.0 0.0 -0.287 74.0 74.0 mesenchymal cell differentiation 0.011 0.1 0.276 64.0 -9999.0 0.0 64.0 mol:Vitamin D3 -0.046 0.145 -9999.0 0.0 -0.384 37.0 37.0 IHH N/PTCH2 0.01 0.055 -9999.0 0.0 -0.322 11.0 11.0 CDON -0.004 0.099 -9999.0 0.0 -0.414 27.0 27.0 IHH N/PTCH1 -0.04 0.144 -9999.0 0.0 -0.424 23.0 23.0 Megalin/LRPAP1 -0.101 0.181 -9999.0 0.0 -0.371 158.0 158.0 PTCH2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.017 0.097 -9999.0 0.0 -0.284 61.0 61.0 PTCH1 -0.042 0.142 -9999.0 0.0 -0.423 23.0 23.0 HHIP 0.01 0.052 -9999.0 0.0 -0.33 11.0 11.0