Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.027 0.127 -9999.0 0.0 -0.255 111.0 111.0 epithelial cell differentiation -0.007 0.104 -9999.0 0.0 -0.256 76.0 76.0 CYFIP2 -0.042 0.163 -9999.0 0.0 -0.464 65.0 65.0 ENAH 0.012 0.097 -9999.0 0.0 -0.314 14.0 14.0 EGFR -0.077 0.173 -9999.0 0.0 -0.351 136.0 136.0 EPHA2 0.008 0.06 -9999.0 0.0 -0.333 14.0 14.0 MYO6 -0.013 0.111 -9999.0 0.0 -0.246 92.0 92.0 CTNNB1 0.001 0.09 -9999.0 0.0 -0.452 19.0 19.0 ABI1/Sra1/Nap1 -0.003 0.105 -9999.0 0.0 -0.31 52.0 52.0 AQP5 -0.086 0.192 -9999.0 0.0 -0.446 97.0 97.0 CTNND1 0.016 0.029 -9999.0 0.0 -0.346 3.0 3.0 mol:PI-4-5-P2 -0.005 0.1 -9999.0 0.0 -0.238 78.0 78.0 regulation of calcium-dependent cell-cell adhesion -0.015 0.105 -9999.0 0.0 -0.245 82.0 82.0 EGF -0.144 0.226 -9999.0 0.0 -0.424 193.0 193.0 NCKAP1 0.015 0.031 -9999.0 0.0 -0.324 4.0 4.0 AQP3 -0.089 0.201 -9999.0 0.0 -0.468 97.0 97.0 cortical microtubule organization -0.007 0.104 -9999.0 0.0 -0.256 76.0 76.0 GO:0000145 -0.006 0.095 -9999.0 0.0 -0.228 78.0 78.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.005 0.107 -9999.0 0.0 -0.258 76.0 76.0 MLLT4 -0.006 0.106 -9999.0 0.0 -0.46 26.0 26.0 ARF6/GDP -0.04 0.086 -9999.0 0.0 -0.389 12.0 12.0 ARF6 0.016 0.033 -9999.0 0.0 -0.521 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.025 0.071 -9999.0 0.0 -0.27 24.0 24.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.007 0.123 -9999.0 0.0 -0.436 15.0 15.0 PVRL2 0.002 0.089 -9999.0 0.0 -0.521 15.0 15.0 ZYX -0.009 0.106 -9999.0 0.0 -0.244 84.0 84.0 ARF6/GTP 0.03 0.072 -9999.0 0.0 -0.272 22.0 22.0 CDH1 -0.049 0.173 -9999.0 0.0 -0.48 71.0 71.0 EGFR/EGFR/EGF/EGF -0.134 0.145 -9999.0 0.0 -0.376 92.0 92.0 RhoA/GDP -0.01 0.107 -9999.0 0.0 -0.247 85.0 85.0 actin cytoskeleton organization -0.008 0.107 -9999.0 0.0 -0.237 76.0 76.0 IGF-1R heterotetramer -0.083 0.203 -9999.0 0.0 -0.468 110.0 110.0 GIT1 0.014 0.035 -9999.0 0.0 -0.302 6.0 6.0 IGF1R -0.083 0.203 -9999.0 0.0 -0.468 110.0 110.0 IGF1 -0.102 0.206 -9999.0 0.0 -0.417 146.0 146.0 DIAPH1 -0.054 0.176 -9999.0 0.0 -0.583 52.0 52.0 Wnt receptor signaling pathway 0.007 0.104 0.256 76.0 -9999.0 0.0 76.0 RHOA 0.005 0.08 -9999.0 0.0 -0.521 12.0 12.0 RhoA/GTP -0.044 0.089 -9999.0 0.0 -0.367 16.0 16.0 CTNNA1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 VCL -0.008 0.109 -9999.0 0.0 -0.395 7.0 7.0 EFNA1 0.0 0.094 -9999.0 0.0 -0.492 18.0 18.0 LPP -0.004 0.105 -9999.0 0.0 -0.231 87.0 87.0 Ephrin A1/EPHA2 -0.045 0.094 -9999.0 0.0 -0.431 8.0 8.0 SEC6/SEC8 -0.045 0.092 -9999.0 0.0 -0.411 10.0 10.0 MGAT3 -0.015 0.107 -9999.0 0.0 -0.248 82.0 82.0 HGF/MET -0.044 0.089 -9999.0 0.0 -0.343 10.0 10.0 HGF 0.008 0.069 -9999.0 0.0 -0.449 11.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.028 0.128 -9999.0 0.0 -0.257 111.0 111.0 actin cable formation 0.017 0.1 -9999.0 0.0 -0.281 21.0 21.0 KIAA1543 0.001 0.101 -9999.0 0.0 -0.336 10.0 10.0 KIFC3 -0.005 0.1 -9999.0 0.0 -0.238 77.0 77.0 NCK1 0.011 0.046 -9999.0 0.0 -0.28 12.0 12.0 EXOC3 0.017 0.012 -9999.0 0.0 -0.258 1.0 1.0 ACTN1 -0.009 0.107 -9999.0 0.0 -0.244 85.0 85.0 NCK1/GIT1 0.019 0.042 -9999.0 0.0 -0.44 2.0 2.0 mol:GDP -0.007 0.104 -9999.0 0.0 -0.256 76.0 76.0 EXOC4 0.016 0.033 -9999.0 0.0 -0.521 2.0 2.0 STX4 -0.003 0.101 -9999.0 0.0 -0.242 76.0 76.0 PIP5K1C -0.005 0.102 -9999.0 0.0 -0.242 78.0 78.0 LIMA1 -0.025 0.146 -9999.0 0.0 -0.521 42.0 42.0 ABI1 0.016 0.021 -9999.0 0.0 -0.258 3.0 3.0 ROCK1 0.009 0.102 -9999.0 0.0 -0.319 16.0 16.0 adherens junction assembly 0.012 0.105 -9999.0 0.0 -0.381 10.0 10.0 IGF-1R heterotetramer/IGF1 -0.124 0.156 -9999.0 0.0 -0.431 73.0 73.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.002 0.103 -9999.0 0.0 -0.388 33.0 33.0 MET -0.001 0.078 -9999.0 0.0 -0.3 31.0 31.0 PLEKHA7 -0.003 0.099 -9999.0 0.0 -0.238 77.0 77.0 mol:GTP 0.024 0.071 -9999.0 0.0 -0.269 24.0 24.0 establishment of epithelial cell apical/basal polarity 0.005 0.113 -9999.0 0.0 -0.409 10.0 10.0 cortical actin cytoskeleton stabilization -0.027 0.127 -9999.0 0.0 -0.255 111.0 111.0 regulation of cell-cell adhesion -0.008 0.107 -9999.0 0.0 -0.237 76.0 76.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.028 0.128 -9999.0 0.0 -0.257 111.0 111.0