Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.039 0.048 0.307 6.0 -9999.0 0.0 6.0 KIRREL 0.025 0.053 -9999.0 0.0 -0.428 6.0 6.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.039 0.048 -9999.0 0.0 -0.308 6.0 6.0 PLCG1 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.029 0.054 -9999.0 0.0 -0.423 7.0 7.0 Nephrin/NEPH1/podocin/CD2AP 0.064 0.057 -9999.0 0.0 -0.239 6.0 6.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.021 0.044 -9999.0 0.0 -0.212 12.0 12.0 FYN 0.059 0.102 0.279 70.0 -0.211 11.0 81.0 mol:Ca2+ 0.057 0.056 -9999.0 0.0 -0.238 6.0 6.0 mol:DAG 0.058 0.057 -9999.0 0.0 -0.239 6.0 6.0 NPHS2 0.03 0.029 -9999.0 0.0 -0.43 1.0 1.0 mol:IP3 0.058 0.057 -9999.0 0.0 -0.239 6.0 6.0 regulation of endocytosis 0.046 0.055 -9999.0 0.0 -0.2 11.0 11.0 Nephrin/NEPH1/podocin/Cholesterol 0.048 0.049 -9999.0 0.0 -0.235 6.0 6.0 establishment of cell polarity 0.039 0.048 -9999.0 0.0 -0.307 6.0 6.0 Nephrin/NEPH1/podocin/NCK1-2 0.075 0.064 -9999.0 0.0 -0.223 7.0 7.0 Nephrin/NEPH1/beta Arrestin2 0.051 0.058 -9999.0 0.0 -0.202 11.0 11.0 NPHS1 0.041 0.03 -9999.0 0.0 -0.387 1.0 1.0 Nephrin/NEPH1/podocin 0.048 0.055 0.202 12.0 -0.212 11.0 23.0 TJP1 0.031 0.036 -9999.0 0.0 -0.423 3.0 3.0 NCK1 0.034 0.022 -9999.0 0.0 -0.423 1.0 1.0 NCK2 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.06 0.058 -9999.0 0.0 -0.239 6.0 6.0 CD2AP 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.06 0.057 -9999.0 0.0 -0.239 6.0 6.0 GRB2 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.058 0.106 0.286 70.0 -0.229 11.0 81.0 cytoskeleton organization 0.023 0.068 0.235 31.0 -0.254 6.0 37.0 Nephrin/NEPH1 0.033 0.036 -9999.0 0.0 -0.21 6.0 6.0 Nephrin/NEPH1/ZO-1 0.05 0.054 -9999.0 0.0 -0.254 9.0 9.0