Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL23-mediated signaling events	36.0	2171.0	60.0	-0.694	0.018	1000.0	-1000.0	-0.133	-1000.0
HIF-1-alpha transcription factor network	31.0	2377.0	76.0	-0.454	0.028	1000.0	-1000.0	-0.076	-1000.0
Syndecan-1-mediated signaling events	27.0	925.0	34.0	-0.258	0.018	1000.0	-1000.0	-0.044	-1000.0
IL4-mediated signaling events	24.0	2223.0	91.0	-0.622	0.541	1000.0	-1000.0	-0.124	-1000.0
Endothelins	23.0	2265.0	96.0	-0.315	0.019	1000.0	-1000.0	-0.061	-1000.0
Wnt signaling	23.0	162.0	7.0	-0.182	0.005	1000.0	-1000.0	-0.024	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	23.0	1591.0	68.0	-0.725	0.246	1000.0	-1000.0	-0.116	-1000.0
Ephrin B reverse signaling	22.0	1087.0	48.0	-0.318	0.095	1000.0	-1000.0	-0.075	-1000.0
Calcium signaling in the CD4+ TCR pathway	21.0	654.0	31.0	-0.456	0.017	1000.0	-1000.0	-0.073	-1000.0
Fc-epsilon receptor I signaling in mast cells	20.0	1947.0	97.0	-0.296	0.051	1000.0	-1000.0	-0.09	-1000.0
IL12-mediated signaling events	19.0	1739.0	87.0	-0.399	0.047	1000.0	-1000.0	-0.116	-1000.0
PLK2 and PLK4 events	19.0	59.0	3.0	-0.086	0.01	1000.0	-1000.0	-0.017	-1000.0
Noncanonical Wnt signaling pathway	19.0	509.0	26.0	-0.182	0.018	1000.0	-1000.0	-0.04	-1000.0
TCGA08_p53	19.0	136.0	7.0	-0.086	0.041	1000.0	-1000.0	-0.012	-1000.0
Thromboxane A2 receptor signaling	17.0	1808.0	105.0	-0.214	0.06	1000.0	-1000.0	-0.07	-1000.0
Glypican 1 network	17.0	863.0	48.0	-0.223	0.018	1000.0	-1000.0	-0.039	-1000.0
TCGA08_retinoblastoma	17.0	142.0	8.0	-0.084	0.035	1000.0	-1000.0	-0.018	-1000.0
Osteopontin-mediated events	16.0	612.0	38.0	-0.29	0.018	1000.0	-1000.0	-0.108	-1000.0
amb2 Integrin signaling	16.0	1389.0	82.0	-0.308	0.024	1000.0	-1000.0	-0.088	-1000.0
Glucocorticoid receptor regulatory network	16.0	1933.0	114.0	-0.571	0.299	1000.0	-1000.0	-0.067	-1000.0
FAS signaling pathway (CD95)	16.0	771.0	47.0	-0.42	0.025	1000.0	-1000.0	-0.045	-1000.0
Signaling mediated by p38-alpha and p38-beta	16.0	716.0	44.0	-0.25	0.018	1000.0	-1000.0	-0.03	-1000.0
IL27-mediated signaling events	16.0	830.0	51.0	-0.301	0.164	1000.0	-1000.0	-0.098	-1000.0
BMP receptor signaling	15.0	1259.0	81.0	-0.428	0.06	1000.0	-1000.0	-0.093	-1000.0
Glypican 2 network	15.0	60.0	4.0	-0.058	-0.0	1000.0	-1000.0	-0.019	-1000.0
IL6-mediated signaling events	15.0	1170.0	75.0	-0.25	0.051	1000.0	-1000.0	-0.073	-1000.0
EGFR-dependent Endothelin signaling events	15.0	328.0	21.0	-0.214	0.027	1000.0	-1000.0	-0.075	-1000.0
IL1-mediated signaling events	14.0	929.0	62.0	-0.292	0.074	1000.0	-1000.0	-0.093	-1000.0
TCR signaling in naïve CD8+ T cells	14.0	1314.0	93.0	-0.147	0.027	1000.0	-1000.0	-0.079	-1000.0
Syndecan-4-mediated signaling events	14.0	940.0	67.0	-0.151	0.03	1000.0	-1000.0	-0.103	-1000.0
Cellular roles of Anthrax toxin	13.0	511.0	39.0	-0.1	0.018	1000.0	-1000.0	-0.027	-1000.0
FOXA2 and FOXA3 transcription factor networks	13.0	637.0	46.0	-0.295	0.048	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by PRL	13.0	444.0	34.0	-0.127	0.05	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	13.0	1091.0	78.0	-0.204	0.08	1000.0	-1000.0	-0.085	-1000.0
Syndecan-2-mediated signaling events	12.0	863.0	69.0	-0.258	0.032	1000.0	-1000.0	-0.025	-1000.0
Presenilin action in Notch and Wnt signaling	12.0	776.0	61.0	-0.282	0.142	1000.0	-1000.0	-0.077	-1000.0
IFN-gamma pathway	12.0	861.0	68.0	-0.243	0.024	1000.0	-1000.0	-0.093	-1000.0
Visual signal transduction: Rods	12.0	675.0	52.0	-0.314	0.018	1000.0	-1000.0	-0.081	-1000.0
Caspase cascade in apoptosis	11.0	872.0	74.0	-0.188	0.076	1000.0	-1000.0	-0.038	-1000.0
Arf6 signaling events	11.0	698.0	62.0	-0.214	0.041	1000.0	-1000.0	-0.03	-1000.0
S1P1 pathway	11.0	400.0	36.0	-0.216	0.018	1000.0	-1000.0	-0.071	-1000.0
Canonical Wnt signaling pathway	11.0	600.0	51.0	-0.313	0.165	1000.0	-1000.0	-0.063	-1000.0
BCR signaling pathway	11.0	1124.0	99.0	-0.24	0.032	1000.0	-1000.0	-0.094	-1000.0
Ras signaling in the CD4+ TCR pathway	11.0	189.0	17.0	-0.076	0.014	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by the Hedgehog family	10.0	536.0	52.0	-0.243	0.152	1000.0	-1000.0	-0.039	-1000.0
PDGFR-alpha signaling pathway	10.0	446.0	44.0	-0.281	0.027	1000.0	-1000.0	-0.063	-1000.0
Nectin adhesion pathway	10.0	645.0	63.0	-0.081	0.024	1000.0	-1000.0	-0.084	-1000.0
Nongenotropic Androgen signaling	10.0	552.0	52.0	-0.157	0.063	1000.0	-1000.0	-0.061	-1000.0
FOXM1 transcription factor network	10.0	539.0	51.0	-0.258	0.041	1000.0	-1000.0	-0.148	-1000.0
LPA receptor mediated events	9.0	974.0	102.0	-0.253	0.038	1000.0	-1000.0	-0.072	-1000.0
IL2 signaling events mediated by STAT5	9.0	211.0	22.0	-0.124	0.019	1000.0	-1000.0	-0.036	-1000.0
Sphingosine 1-phosphate (S1P) pathway	8.0	225.0	28.0	-0.096	0.027	1000.0	-1000.0	-0.024	-1000.0
a4b1 and a4b7 Integrin signaling	8.0	42.0	5.0	-0.027	0.002	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by PTP1B	8.0	612.0	76.0	-0.215	0.055	1000.0	-1000.0	-0.078	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	8.0	379.0	45.0	-0.144	0.047	1000.0	-1000.0	-0.088	-1000.0
EPHB forward signaling	8.0	690.0	85.0	-0.174	0.114	1000.0	-1000.0	-0.092	-1000.0
Syndecan-3-mediated signaling events	7.0	265.0	35.0	-0.258	0.018	1000.0	-1000.0	-0.043	-1000.0
Class I PI3K signaling events	7.0	531.0	73.0	-0.085	0.026	1000.0	-1000.0	-0.053	-1000.0
E-cadherin signaling events	7.0	37.0	5.0	-0.02	0.015	1000.0	-1000.0	-0.019	-1000.0
ErbB4 signaling events	6.0	440.0	69.0	-0.325	0.065	1000.0	-1000.0	-0.091	-1000.0
Visual signal transduction: Cones	6.0	255.0	38.0	-0.074	0.018	1000.0	-1000.0	-0.069	-1000.0
JNK signaling in the CD4+ TCR pathway	6.0	108.0	17.0	-0.063	0.015	1000.0	-1000.0	-0.034	-1000.0
Hedgehog signaling events mediated by Gli proteins	6.0	401.0	65.0	-0.16	0.047	1000.0	-1000.0	-0.052	-1000.0
p75(NTR)-mediated signaling	6.0	862.0	125.0	-0.24	0.035	1000.0	-1000.0	-0.093	-1000.0
Ceramide signaling pathway	6.0	518.0	76.0	-0.214	0.081	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by HDAC Class III	6.0	255.0	40.0	-0.101	0.031	1000.0	-1000.0	-0.04	-1000.0
Reelin signaling pathway	6.0	358.0	56.0	-0.155	0.036	1000.0	-1000.0	-0.084	-1000.0
TRAIL signaling pathway	6.0	324.0	48.0	-0.088	0.032	1000.0	-1000.0	-0.074	-1000.0
Regulation of Telomerase	6.0	656.0	102.0	-0.35	0.061	1000.0	-1000.0	-0.113	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	773.0	136.0	-0.182	0.055	1000.0	-1000.0	-0.064	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	5.0	428.0	85.0	-0.186	0.055	1000.0	-1000.0	-0.071	-1000.0
Arf6 downstream pathway	5.0	257.0	43.0	-0.028	0.026	1000.0	-1000.0	-0.042	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	5.0	194.0	37.0	-0.027	0.027	1000.0	-1000.0	-0.053	-1000.0
HIF-2-alpha transcription factor network	5.0	256.0	43.0	-0.107	0.045	1000.0	-1000.0	-0.066	-1000.0
IL2 signaling events mediated by PI3K	5.0	319.0	58.0	-0.109	0.032	1000.0	-1000.0	-0.086	-1000.0
Integrins in angiogenesis	5.0	459.0	84.0	-0.294	0.043	1000.0	-1000.0	-0.107	-1000.0
Effects of Botulinum toxin	5.0	147.0	26.0	-0.19	0.024	1000.0	-1000.0	-0.054	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	422.0	76.0	-0.066	0.03	1000.0	-1000.0	-0.086	-1000.0
Insulin Pathway	5.0	416.0	74.0	-0.293	0.044	1000.0	-1000.0	-0.095	-1000.0
VEGFR1 specific signals	5.0	300.0	56.0	-0.02	0.033	1000.0	-1000.0	-0.037	-1000.0
S1P3 pathway	5.0	227.0	42.0	-0.068	0.027	1000.0	-1000.0	-0.038	-1000.0
PDGFR-beta signaling pathway	5.0	491.0	97.0	-0.098	0.042	1000.0	-1000.0	-0.091	-1000.0
LPA4-mediated signaling events	4.0	51.0	12.0	-0.008	0.019	1000.0	-1000.0	-0.024	-1000.0
Coregulation of Androgen receptor activity	4.0	327.0	76.0	-0.178	0.039	1000.0	-1000.0	-0.042	-1000.0
Ephrin A  reverse signaling	4.0	28.0	7.0	-0.002	0.014	1000.0	-1000.0	-0.025	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	4.0	243.0	52.0	-0.232	0.063	1000.0	-1000.0	-0.047	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	74.0	15.0	-0.028	0.02	1000.0	-1000.0	-0.027	-1000.0
Retinoic acid receptors-mediated signaling	4.0	253.0	58.0	-0.22	0.097	1000.0	-1000.0	-0.084	-1000.0
Regulation of p38-alpha and p38-beta	4.0	227.0	54.0	-0.085	0.039	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	4.0	560.0	125.0	-0.068	0.074	1000.0	-1000.0	-0.105	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	345.0	74.0	-0.214	0.039	1000.0	-1000.0	-0.094	-1000.0
Plasma membrane estrogen receptor signaling	4.0	403.0	86.0	-0.099	0.045	1000.0	-1000.0	-0.077	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	4.0	133.0	33.0	-0.114	0.048	1000.0	-1000.0	-0.041	-1000.0
Class IB PI3K non-lipid kinase events	4.0	12.0	3.0	-0.002	0.002	1000.0	-1000.0	-0.014	-1000.0
Regulation of Androgen receptor activity	4.0	326.0	70.0	-0.153	0.072	1000.0	-1000.0	-0.067	-1000.0
Aurora B signaling	4.0	328.0	67.0	-0.165	0.018	1000.0	-1000.0	-0.073	-1000.0
BARD1 signaling events	3.0	224.0	57.0	-0.108	0.042	1000.0	-1000.0	-0.051	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	3.0	215.0	54.0	-0.155	0.059	1000.0	-1000.0	-0.094	-1000.0
Aurora A signaling	3.0	185.0	60.0	-0.036	0.034	1000.0	-1000.0	-0.032	-1000.0
Aurora C signaling	3.0	23.0	7.0	-0.017	0.01	1000.0	-1000.0	-0.035	-1000.0
EPO signaling pathway	3.0	202.0	55.0	-0.06	0.042	1000.0	-1000.0	-0.094	-1000.0
PLK1 signaling events	3.0	331.0	85.0	-0.062	0.038	1000.0	-1000.0	-0.046	-1000.0
mTOR signaling pathway	3.0	204.0	53.0	-0.016	0.052	1000.0	-1000.0	-0.064	-1000.0
Signaling events regulated by Ret tyrosine kinase	3.0	314.0	82.0	-0.049	0.032	1000.0	-1000.0	-0.086	-1000.0
ceramide signaling pathway	3.0	148.0	49.0	-0.073	0.042	1000.0	-1000.0	-0.041	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	3.0	300.0	83.0	-0.065	0.055	1000.0	-1000.0	-0.078	-1000.0
FoxO family signaling	3.0	249.0	64.0	-0.157	0.081	1000.0	-1000.0	-0.058	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	109.0	36.0	-0.033	0.035	1000.0	-1000.0	-0.07	-1000.0
TCGA08_rtk_signaling	3.0	100.0	26.0	-0.034	0.044	1000.0	-1000.0	-0.016	-1000.0
Arf6 trafficking events	3.0	262.0	71.0	-0.09	0.046	1000.0	-1000.0	-0.084	-1000.0
Angiopoietin receptor Tie2-mediated signaling	3.0	266.0	88.0	-0.293	0.076	1000.0	-1000.0	-0.107	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	3.0	373.0	120.0	-0.069	0.068	1000.0	-1000.0	-0.079	-1000.0
p38 MAPK signaling pathway	3.0	135.0	44.0	-0.018	0.035	1000.0	-1000.0	-0.067	-1000.0
ErbB2/ErbB3 signaling events	2.0	176.0	65.0	-0.083	0.052	1000.0	-1000.0	-0.061	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	2.0	54.0	23.0	-0.01	0.037	1000.0	-1000.0	-0.053	-1000.0
Canonical NF-kappaB pathway	2.0	95.0	39.0	-0.084	0.071	1000.0	-1000.0	-0.085	-1000.0
Signaling events mediated by HDAC Class II	2.0	154.0	75.0	-0.03	0.039	1000.0	-1000.0	-0.055	-1000.0
Circadian rhythm pathway	2.0	48.0	22.0	-0.016	0.049	1000.0	-1000.0	-0.03	-1000.0
S1P5 pathway	2.0	45.0	17.0	-0.057	0.018	1000.0	-1000.0	-0.021	-1000.0
Atypical NF-kappaB pathway	2.0	72.0	31.0	-0.062	0.033	1000.0	-1000.0	-0.042	-1000.0
IGF1 pathway	2.0	165.0	57.0	-0.036	0.038	1000.0	-1000.0	-0.096	-1000.0
E-cadherin signaling in keratinocytes	2.0	115.0	43.0	-0.033	0.036	1000.0	-1000.0	-0.071	-1000.0
S1P4 pathway	2.0	60.0	25.0	-0.057	0.031	1000.0	-1000.0	-0.024	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	1.0	41.0	34.0	-0.015	0.039	1000.0	-1000.0	-0.034	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	80.0	68.0	-0.044	0.059	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by HDAC Class I	1.0	129.0	104.0	-0.036	0.056	1000.0	-1000.0	-0.077	-1000.0
Insulin-mediated glucose transport	0.0	29.0	32.0	-0.005	0.04	1000.0	-1000.0	-0.035	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	23.0	27.0	-0.008	0.038	1000.0	-1000.0	-0.063	-1000.0
Rapid glucocorticoid signaling	0.0	18.0	20.0	0.0	0.024	1000.0	-1000.0	-0.016	-1000.0
Arf1 pathway	0.0	34.0	54.0	-0.009	0.041	1000.0	-1000.0	-0.033	-1000.0
Alternative NF-kappaB pathway	0.0	11.0	13.0	-0.0	0.045	1000.0	-1000.0	-0.03	-1000.0
Total	1125	66499	7203	-21.6745056257	6.53606788016	131000	-131000	-8.14045113174	-131000