Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.019 0.113 -9999.0 0.0 -0.535 5.0 5.0 IHH 0.026 0.099 -9999.0 0.0 -0.394 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.086 0.155 -9999.0 0.0 -0.323 37.0 37.0 LRPAP1 0.036 0.009 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.086 0.154 0.321 37.0 -9999.0 0.0 37.0 SMO/beta Arrestin2 0.007 0.128 -9999.0 0.0 -0.406 8.0 8.0 SMO -0.007 0.125 -9999.0 0.0 -0.36 14.0 14.0 AKT1 -0.027 0.168 -9999.0 0.0 -0.561 7.0 7.0 ARRB2 0.029 0.017 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.025 0.066 -9999.0 0.0 -0.276 6.0 6.0 ADRBK1 0.038 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.007 0.123 -9999.0 0.0 -0.356 14.0 14.0 STIL -0.003 0.117 0.35 1.0 -0.26 21.0 22.0 DHH N/PTCH2 0.056 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.03 0.08 -9999.0 0.0 -0.322 6.0 6.0 PIK3CA 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.038 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.006 0.172 -9999.0 0.0 -0.861 5.0 5.0 determination of left/right symmetry -0.007 0.123 -9999.0 0.0 -0.356 14.0 14.0 PIK3R1 0.026 0.077 -9999.0 0.0 -0.508 3.0 3.0 skeletal system development 0.006 0.17 -9999.0 0.0 -0.85 5.0 5.0 IHH N/Hhip -0.005 0.15 -9999.0 0.0 -0.391 16.0 16.0 DHH N/Hhip 0.008 0.124 -9999.0 0.0 -0.369 12.0 12.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.007 0.123 -9999.0 0.0 -0.356 14.0 14.0 pancreas development -0.019 0.156 -9999.0 0.0 -0.405 19.0 19.0 HHAT -0.003 0.139 -9999.0 0.0 -0.461 12.0 12.0 PI3K 0.045 0.061 -9999.0 0.0 -0.369 3.0 3.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.138 0.219 -9999.0 0.0 -0.362 65.0 65.0 somite specification -0.007 0.123 -9999.0 0.0 -0.356 14.0 14.0 SHH Np/Cholesterol/PTCH1 -0.004 0.1 -9999.0 0.0 -0.266 17.0 17.0 SHH Np/Cholesterol/PTCH2 0.011 0.087 -9999.0 0.0 -0.284 11.0 11.0 SHH Np/Cholesterol/Megalin 0.01 0.088 -9999.0 0.0 -0.284 11.0 11.0 SHH -0.012 0.104 -9999.0 0.0 -0.369 11.0 11.0 catabolic process 0.009 0.083 -9999.0 0.0 -0.361 6.0 6.0 SMO/Vitamin D3 -0.015 0.118 -9999.0 0.0 -0.356 10.0 10.0 SHH Np/Cholesterol/Hhip -0.024 0.13 -9999.0 0.0 -0.318 21.0 21.0 LRP2 0.036 0.022 -9999.0 0.0 -0.23 1.0 1.0 receptor-mediated endocytosis -0.013 0.113 -9999.0 0.0 -0.338 10.0 10.0 SHH Np/Cholesterol/BOC 0.005 0.09 -9999.0 0.0 -0.284 11.0 11.0 SHH Np/Cholesterol/CDO 0.009 0.088 -9999.0 0.0 -0.284 11.0 11.0 mesenchymal cell differentiation 0.024 0.129 0.316 21.0 -9999.0 0.0 21.0 mol:Vitamin D3 0.006 0.111 0.226 7.0 -0.266 17.0 24.0 IHH N/PTCH2 0.046 0.066 -9999.0 0.0 -0.355 3.0 3.0 CDON 0.035 0.031 -9999.0 0.0 -0.23 2.0 2.0 IHH N/PTCH1 0.029 0.089 -9999.0 0.0 -0.364 6.0 6.0 Megalin/LRPAP1 0.052 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.038 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.003 0.082 -9999.0 0.0 -0.284 11.0 11.0 PTCH1 0.009 0.083 -9999.0 0.0 -0.362 6.0 6.0 HHIP -0.02 0.156 -9999.0 0.0 -0.405 19.0 19.0