Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.01 0.22 -9999.0 0.0 -0.773 13.0 13.0 IHH 0.002 0.122 -9999.0 0.0 -0.626 7.0 7.0 SHH Np/Cholesterol/GAS1 -0.143 0.2 -9999.0 0.0 -0.416 55.0 55.0 LRPAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.142 0.198 0.413 55.0 -9999.0 0.0 55.0 SMO/beta Arrestin2 -0.014 0.197 -9999.0 0.0 -0.695 11.0 11.0 SMO -0.022 0.205 -9999.0 0.0 -0.725 11.0 11.0 AKT1 0.011 0.127 -9999.0 0.0 -0.656 4.0 4.0 ARRB2 0.015 0.042 -9999.0 0.0 -0.609 1.0 1.0 BOC -0.003 0.098 -9999.0 0.0 -0.482 9.0 9.0 ADRBK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.021 0.2 -9999.0 0.0 -0.707 11.0 11.0 STIL -0.011 0.182 -9999.0 0.0 -0.597 11.0 11.0 DHH N/PTCH2 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.019 0.159 -9999.0 0.0 -0.628 9.0 9.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.0 0.265 -9999.0 0.0 -0.972 13.0 13.0 determination of left/right symmetry -0.021 0.2 -9999.0 0.0 -0.707 11.0 11.0 PIK3R1 0.009 0.072 -9999.0 0.0 -0.609 3.0 3.0 skeletal system development 0.001 0.26 -9999.0 0.0 -0.954 13.0 13.0 IHH N/Hhip -0.067 0.206 -9999.0 0.0 -0.475 43.0 43.0 DHH N/Hhip -0.052 0.168 -9999.0 0.0 -0.408 40.0 40.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.021 0.2 -9999.0 0.0 -0.707 11.0 11.0 pancreas development -0.087 0.226 -9999.0 0.0 -0.569 40.0 40.0 HHAT -0.038 0.172 -9999.0 0.0 -0.568 21.0 21.0 PI3K 0.02 0.054 -9999.0 0.0 -0.441 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.222 0.276 -9999.0 0.0 -0.53 98.0 98.0 somite specification -0.021 0.2 -9999.0 0.0 -0.707 11.0 11.0 SHH Np/Cholesterol/PTCH1 -0.01 0.178 -9999.0 0.0 -0.584 11.0 11.0 SHH Np/Cholesterol/PTCH2 -0.009 0.112 -9999.0 0.0 -0.349 17.0 17.0 SHH Np/Cholesterol/Megalin -0.011 0.114 -9999.0 0.0 -0.349 17.0 17.0 SHH -0.023 0.143 -9999.0 0.0 -0.41 26.0 26.0 catabolic process 0.012 0.174 -9999.0 0.0 -0.565 14.0 14.0 SMO/Vitamin D3 -0.025 0.198 -9999.0 0.0 -0.61 14.0 14.0 SHH Np/Cholesterol/Hhip -0.068 0.179 -9999.0 0.0 -0.394 41.0 41.0 LRP2 0.013 0.045 -9999.0 0.0 -0.466 2.0 2.0 receptor-mediated endocytosis -0.014 0.193 -9999.0 0.0 -0.583 14.0 14.0 SHH Np/Cholesterol/BOC -0.02 0.121 -9999.0 0.0 -0.349 18.0 18.0 SHH Np/Cholesterol/CDO -0.011 0.114 -9999.0 0.0 -0.349 17.0 17.0 mesenchymal cell differentiation 0.068 0.178 0.391 41.0 -9999.0 0.0 41.0 mol:Vitamin D3 -0.006 0.18 -9999.0 0.0 -0.587 11.0 11.0 IHH N/PTCH2 0.017 0.077 -9999.0 0.0 -0.441 5.0 5.0 CDON 0.013 0.045 -9999.0 0.0 -0.466 2.0 2.0 IHH N/PTCH1 0.014 0.177 -9999.0 0.0 -0.571 14.0 14.0 Megalin/LRPAP1 0.023 0.033 -9999.0 0.0 -0.321 2.0 2.0 PTCH2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.02 0.111 -9999.0 0.0 -0.359 17.0 17.0 PTCH1 0.012 0.175 -9999.0 0.0 -0.568 14.0 14.0 HHIP -0.087 0.226 -9999.0 0.0 -0.57 40.0 40.0