Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.007 0.07 -9999.0 0.0 -0.241 15.0 15.0 epithelial cell differentiation 0.045 0.092 -9999.0 0.0 -0.256 15.0 15.0 CYFIP2 0.012 0.11 -9999.0 0.0 -0.456 11.0 11.0 ENAH -0.042 0.08 -9999.0 0.0 -0.354 5.0 5.0 EGFR 0.016 0.088 -9999.0 0.0 -0.413 8.0 8.0 EPHA2 0.012 0.087 -9999.0 0.0 -0.283 15.0 15.0 MYO6 -0.008 0.08 -9999.0 0.0 -0.248 18.0 18.0 CTNNB1 0.014 0.092 -9999.0 0.0 -0.301 15.0 15.0 ABI1/Sra1/Nap1 0.047 0.088 -9999.0 0.0 -0.305 10.0 10.0 AQP5 -0.021 0.091 -9999.0 0.0 -0.471 4.0 4.0 CTNND1 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.003 0.073 -9999.0 0.0 -0.244 15.0 15.0 regulation of calcium-dependent cell-cell adhesion -0.04 0.101 -9999.0 0.0 -0.246 35.0 35.0 EGF -0.094 0.189 -9999.0 0.0 -0.32 79.0 79.0 NCKAP1 0.023 0.067 -9999.0 0.0 -0.265 10.0 10.0 AQP3 -0.035 0.107 -9999.0 0.0 -0.418 10.0 10.0 cortical microtubule organization 0.045 0.092 -9999.0 0.0 -0.256 15.0 15.0 GO:0000145 -0.026 0.063 -9999.0 0.0 -0.233 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.052 0.095 -9999.0 0.0 -0.259 15.0 15.0 MLLT4 0.022 0.085 -9999.0 0.0 -0.48 6.0 6.0 ARF6/GDP -0.049 0.086 -9999.0 0.0 -0.379 7.0 7.0 ARF6 0.029 0.05 -9999.0 0.0 -0.48 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.048 0.097 -9999.0 0.0 -0.285 11.0 11.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.014 0.074 -9999.0 0.0 -0.294 3.0 3.0 PVRL2 0.033 0.042 -9999.0 0.0 -0.301 3.0 3.0 ZYX -0.006 0.077 -9999.0 0.0 -0.247 17.0 17.0 ARF6/GTP 0.048 0.102 -9999.0 0.0 -0.27 13.0 13.0 CDH1 0.013 0.108 -9999.0 0.0 -0.48 10.0 10.0 EGFR/EGFR/EGF/EGF -0.041 0.137 -9999.0 0.0 -0.27 44.0 44.0 RhoA/GDP 0.048 0.09 -9999.0 0.0 -0.245 15.0 15.0 actin cytoskeleton organization -0.03 0.07 -9999.0 0.0 -0.316 1.0 1.0 IGF-1R heterotetramer 0.031 0.04 -9999.0 0.0 -0.345 2.0 2.0 GIT1 0.035 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.031 0.04 -9999.0 0.0 -0.346 2.0 2.0 IGF1 0.016 0.082 -9999.0 0.0 -0.265 15.0 15.0 DIAPH1 0.027 0.183 -9999.0 0.0 -0.612 15.0 15.0 Wnt receptor signaling pathway -0.045 0.092 0.256 15.0 -9999.0 0.0 15.0 RHOA 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.048 0.085 -9999.0 0.0 -0.398 6.0 6.0 CTNNA1 0.036 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.031 0.072 -9999.0 0.0 -0.323 1.0 1.0 EFNA1 0.023 0.075 -9999.0 0.0 -0.365 7.0 7.0 LPP -0.026 0.063 -9999.0 0.0 -0.312 1.0 1.0 Ephrin A1/EPHA2 0.017 0.117 -9999.0 0.0 -0.298 20.0 20.0 SEC6/SEC8 -0.011 0.092 -9999.0 0.0 -0.398 7.0 7.0 MGAT3 -0.04 0.103 -9999.0 0.0 -0.249 35.0 35.0 HGF/MET 0.031 0.096 -9999.0 0.0 -0.261 16.0 16.0 HGF 0.031 0.043 -9999.0 0.0 -0.301 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.007 0.071 -9999.0 0.0 -0.242 15.0 15.0 actin cable formation -0.025 0.09 0.245 1.0 -0.318 5.0 6.0 KIAA1543 -0.033 0.077 -9999.0 0.0 -0.34 5.0 5.0 KIFC3 -0.006 0.077 -9999.0 0.0 -0.248 16.0 16.0 NCK1 0.027 0.07 -9999.0 0.0 -0.48 4.0 4.0 EXOC3 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.004 0.073 -9999.0 0.0 -0.248 15.0 15.0 NCK1/GIT1 0.043 0.056 -9999.0 0.0 -0.347 4.0 4.0 mol:GDP 0.045 0.092 -9999.0 0.0 -0.256 15.0 15.0 EXOC4 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.029 0.062 -9999.0 0.0 -0.246 15.0 15.0 PIP5K1C -0.003 0.074 -9999.0 0.0 -0.248 15.0 15.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.035 0.085 -9999.0 0.0 -0.394 4.0 4.0 adherens junction assembly -0.018 0.089 -9999.0 0.0 -0.416 3.0 3.0 IGF-1R heterotetramer/IGF1 0.022 0.099 -9999.0 0.0 -0.25 19.0 19.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.074 -9999.0 0.0 -0.301 9.0 9.0 MET 0.028 0.055 -9999.0 0.0 -0.346 4.0 4.0 PLEKHA7 -0.003 0.074 -9999.0 0.0 -0.248 15.0 15.0 mol:GTP 0.046 0.095 -9999.0 0.0 -0.283 11.0 11.0 establishment of epithelial cell apical/basal polarity -0.032 0.087 -9999.0 0.0 -0.383 7.0 7.0 cortical actin cytoskeleton stabilization 0.007 0.07 -9999.0 0.0 -0.241 15.0 15.0 regulation of cell-cell adhesion -0.03 0.07 -9999.0 0.0 -0.316 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.007 0.071 -9999.0 0.0 -0.242 15.0 15.0