E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.008 0.071 -9999.0 0.0 -0.296 21.0 21.0 KLHL20 0.049 0.094 0.205 71.0 -0.188 18.0 89.0 CYFIP2 0.031 0.013 -9999.0 0.0 0.0 76.0 76.0 Rac1/GDP 0.009 0.062 0.204 1.0 -0.262 12.0 13.0 ENAH 0.007 0.074 -9999.0 0.0 -0.317 20.0 20.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.0 0.0 0.0 39.0 -0.0 9.0 48.0 RAP1A 0.036 0.005 -9999.0 0.0 0.0 10.0 10.0 CTNNB1 0.036 0.006 -9999.0 0.0 0.0 15.0 15.0 CDC42/GTP -0.023 0.056 0.12 24.0 -0.206 21.0 45.0 ABI1/Sra1/Nap1 -0.015 0.034 -9999.0 0.0 -0.133 29.0 29.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.083 0.039 -9999.0 0.0 -0.131 8.0 8.0 RAPGEF1 -0.0 0.078 0.215 1.0 -0.292 16.0 17.0 CTNND1 0.035 0.009 -9999.0 0.0 0.0 31.0 31.0 regulation of calcium-dependent cell-cell adhesion 0.021 0.075 -9999.0 0.0 -0.296 22.0 22.0 CRK 0.007 0.08 -9999.0 0.0 -0.293 20.0 20.0 E-cadherin/gamma catenin/alpha catenin 0.062 0.035 -9999.0 0.0 -0.126 8.0 8.0 alphaE/beta7 Integrin 0.049 0.026 -9999.0 0.0 -0.145 7.0 7.0 IQGAP1 0.033 0.011 -9999.0 0.0 0.0 47.0 47.0 NCKAP1 0.037 0.002 -9999.0 0.0 0.0 2.0 2.0 Rap1/GTP/I-afadin 0.043 0.015 -9999.0 0.0 -0.103 1.0 1.0 DLG1 0.008 0.075 -9999.0 0.0 -0.3 22.0 22.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.034 0.044 -9999.0 0.0 -0.18 29.0 29.0 MLLT4 0.034 0.009 -9999.0 0.0 0.0 34.0 34.0 ARF6/GTP/NME1/Tiam1 0.036 0.033 -9999.0 0.0 -0.103 23.0 23.0 PI3K -0.041 0.058 0.06 1.0 -0.232 29.0 30.0 ARF6 0.035 0.009 -9999.0 0.0 0.0 29.0 29.0 mol:Ca2+ 0.0 0.0 0.001 68.0 -0.0 29.0 97.0 E-cadherin/gamma catenin 0.048 0.018 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.033 0.011 -9999.0 0.0 0.0 46.0 46.0 E-cadherin(dimer)/Ca2+ 0.071 0.054 -9999.0 0.0 -0.141 25.0 25.0 AKT1 -0.02 0.056 0.134 9.0 -0.181 24.0 33.0 PIK3R1 0.032 0.012 -9999.0 0.0 0.0 63.0 63.0 CDH1 0.034 0.01 -9999.0 0.0 0.0 37.0 37.0 RhoA/GDP 0.017 0.074 0.201 5.0 -0.25 15.0 20.0 actin cytoskeleton organization 0.041 0.076 0.17 72.0 -0.14 17.0 89.0 CDC42/GDP 0.016 0.072 0.204 4.0 -0.246 14.0 18.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.011 0.05 -9999.0 0.0 -0.197 23.0 23.0 ITGB7 0.036 0.006 -9999.0 0.0 0.0 14.0 14.0 RAC1 0.025 0.017 -9999.0 0.0 0.0 163.0 163.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.077 0.058 -9999.0 0.0 -0.151 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.056 0.031 -9999.0 0.0 -0.113 10.0 10.0 mol:GDP -0.0 0.076 0.199 4.0 -0.29 13.0 17.0 CDC42/GTP/IQGAP1 0.035 0.042 -9999.0 0.0 -0.117 33.0 33.0 JUP 0.033 0.011 -9999.0 0.0 0.0 51.0 51.0 p120 catenin/RhoA/GDP 0.031 0.082 0.215 5.0 -0.247 18.0 23.0 RAC1/GTP/IQGAP1 0.024 0.043 -9999.0 0.0 -0.12 30.0 30.0 PIP5K1C/AP1M1 0.02 0.03 -9999.0 0.0 -0.134 18.0 18.0 RHOA 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 CDC42 0.035 0.008 -9999.0 0.0 0.0 26.0 26.0 CTNNA1 0.036 0.007 -9999.0 0.0 0.0 18.0 18.0 positive regulation of S phase of mitotic cell cycle 0.015 0.048 0.12 18.0 -0.121 32.0 50.0 NME1 -0.0 0.0 -9999.0 0.0 -0.0 32.0 32.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.009 0.073 -9999.0 0.0 -0.305 20.0 20.0 regulation of cell-cell adhesion -0.027 0.04 -9999.0 0.0 -0.172 25.0 25.0 WASF2 -0.008 0.018 -9999.0 0.0 -0.073 29.0 29.0 Rap1/GTP -0.019 0.067 0.15 32.0 -0.223 22.0 54.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.091 0.051 -9999.0 0.0 -0.132 12.0 12.0 CCND1 0.017 0.057 0.137 18.0 -0.147 32.0 50.0 VAV2 0.024 0.109 -9999.0 0.0 -0.523 10.0 10.0 RAP1/GDP -0.006 0.069 0.16 29.0 -0.254 15.0 44.0 adherens junction assembly 0.009 0.071 -9999.0 0.0 -0.296 20.0 20.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.017 -9999.0 0.0 0.0 158.0 158.0 PIP5K1C 0.033 0.011 -9999.0 0.0 0.0 47.0 47.0 regulation of heterotypic cell-cell adhesion 0.069 0.047 0.201 3.0 -0.138 13.0 16.0 E-cadherin/beta catenin 0.007 0.02 -9999.0 0.0 -0.099 5.0 5.0 mol:GTP 0.0 0.0 0.001 63.0 -0.0 32.0 95.0 SRC 0.007 0.07 -9999.0 0.0 -0.291 21.0 21.0 PIK3CA 0.031 0.014 -9999.0 0.0 0.0 82.0 82.0 Rac1/GTP -0.008 0.07 0.168 2.0 -0.29 18.0 20.0 E-cadherin/beta catenin/alpha catenin 0.064 0.036 -9999.0 0.0 -0.136 10.0 10.0 ITGAE 0.035 0.007 -9999.0 0.0 0.0 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.021 0.077 -9999.0 0.0 -0.301 22.0 22.0