Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.035 0.032 -9999.0 0.0 -9999.0 0.0 0.0 IHH 0.052 0.012 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 0.014 0.028 -9999.0 0.0 -0.112 16.0 16.0 LRPAP1 0.036 0.007 -9999.0 0.0 0.0 17.0 17.0 dorsoventral neural tube patterning -0.014 0.027 0.112 16.0 -9999.0 0.0 16.0 SMO/beta Arrestin2 0.09 0.063 0.262 12.0 -9999.0 0.0 12.0 SMO 0.025 0.031 0.194 1.0 -9999.0 0.0 1.0 AKT1 -0.008 0.129 -9999.0 0.0 -0.443 30.0 30.0 ARRB2 0.035 0.008 -9999.0 0.0 0.0 25.0 25.0 BOC -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.036 0.005 -9999.0 0.0 0.0 10.0 10.0 heart looping 0.026 0.034 0.222 3.0 -9999.0 0.0 3.0 STIL 0.05 0.092 0.187 145.0 -9999.0 0.0 145.0 DHH N/PTCH2 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.017 0.021 0.115 21.0 -9999.0 0.0 21.0 PIK3CA 0.031 0.014 -9999.0 0.0 0.0 82.0 82.0 DHH -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.038 0.048 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry 0.026 0.034 0.222 3.0 -9999.0 0.0 3.0 PIK3R1 0.032 0.012 -9999.0 0.0 0.0 63.0 63.0 skeletal system development 0.038 0.048 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.026 0.034 0.222 3.0 -9999.0 0.0 3.0 pancreas development 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.035 0.007 -9999.0 0.0 0.0 18.0 18.0 PI3K 0.018 0.076 -9999.0 0.0 -0.16 72.0 72.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.031 0.014 -9999.0 0.0 0.0 86.0 86.0 somite specification 0.026 0.034 0.222 3.0 -9999.0 0.0 3.0 SHH Np/Cholesterol/PTCH1 0.018 0.025 0.168 1.0 -9999.0 0.0 1.0 SHH Np/Cholesterol/PTCH2 0.021 0.016 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin 0.02 0.016 -9999.0 0.0 -9999.0 0.0 0.0 SHH -0.015 0.012 0.093 1.0 -9999.0 0.0 1.0 catabolic process 0.02 0.026 0.14 22.0 -9999.0 0.0 22.0 SMO/Vitamin D3 0.022 0.037 0.192 14.0 -9999.0 0.0 14.0 SHH Np/Cholesterol/Hhip -0.01 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LRP2 0.036 0.006 -9999.0 0.0 0.0 12.0 12.0 receptor-mediated endocytosis 0.023 0.039 0.181 16.0 -9999.0 0.0 16.0 SHH Np/Cholesterol/BOC -0.01 0.008 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/CDO 0.021 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation 0.01 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:Vitamin D3 0.075 0.087 0.196 163.0 -9999.0 0.0 163.0 IHH N/PTCH2 0.061 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.036 0.004 -9999.0 0.0 0.0 7.0 7.0 IHH N/PTCH1 0.046 0.028 0.172 21.0 -9999.0 0.0 21.0 Megalin/LRPAP1 0.049 0.029 -9999.0 0.0 -0.145 10.0 10.0 PTCH2 0.036 0.005 -9999.0 0.0 0.0 8.0 8.0 SHH Np/Cholesterol 0.012 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.02 0.026 0.14 22.0 -9999.0 0.0 22.0 HHIP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0