Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.008 0.059 -9999.0 0.0 -0.22 25.0 25.0 epithelial cell differentiation 0.064 0.052 -9999.0 0.0 -0.139 25.0 25.0 CYFIP2 0.031 0.013 -9999.0 0.0 0.0 76.0 76.0 ENAH -0.042 0.072 0.245 12.0 -0.238 11.0 23.0 EGFR 0.009 0.016 -9999.0 0.0 0.0 379.0 379.0 EPHA2 0.033 0.011 -9999.0 0.0 0.0 55.0 55.0 MYO6 -0.029 0.05 0.183 9.0 -0.218 13.0 22.0 CTNNB1 0.036 0.006 -9999.0 0.0 0.0 15.0 15.0 ABI1/Sra1/Nap1 0.029 0.065 -9999.0 0.0 -0.123 60.0 60.0 AQP5 -0.021 0.053 0.188 3.0 -0.288 10.0 13.0 CTNND1 0.035 0.009 -9999.0 0.0 0.0 31.0 31.0 mol:PI-4-5-P2 -0.031 0.045 0.174 7.0 -0.209 13.0 20.0 regulation of calcium-dependent cell-cell adhesion -0.028 0.044 0.183 8.0 -0.194 8.0 16.0 EGF 0.035 0.008 -9999.0 0.0 0.0 25.0 25.0 NCKAP1 0.037 0.002 -9999.0 0.0 0.0 2.0 2.0 AQP3 -0.034 0.075 -9999.0 0.0 -0.299 31.0 31.0 cortical microtubule organization 0.064 0.052 -9999.0 0.0 -0.139 25.0 25.0 GO:0000145 -0.03 0.041 0.157 7.0 -0.2 13.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.071 0.054 -9999.0 0.0 -0.14 25.0 25.0 MLLT4 0.034 0.009 -9999.0 0.0 0.0 34.0 34.0 ARF6/GDP -0.053 0.04 -9999.0 0.0 -0.222 13.0 13.0 ARF6 0.035 0.009 -9999.0 0.0 0.0 29.0 29.0 Ephrin A1/EPHA2/NCK1/GIT1 0.075 0.055 -9999.0 0.0 -0.13 25.0 25.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.031 0.087 0.16 1.0 -0.302 36.0 37.0 PVRL2 0.034 0.009 -9999.0 0.0 0.0 35.0 35.0 ZYX -0.022 0.045 0.176 6.0 -0.215 15.0 21.0 ARF6/GTP 0.079 0.061 -9999.0 0.0 -0.13 24.0 24.0 CDH1 0.034 0.01 -9999.0 0.0 0.0 37.0 37.0 EGFR/EGFR/EGF/EGF -0.001 0.06 -9999.0 0.0 -0.127 67.0 67.0 RhoA/GDP 0.064 0.057 -9999.0 0.0 -0.143 29.0 29.0 actin cytoskeleton organization -0.024 0.047 0.165 7.0 -0.23 12.0 19.0 IGF-1R heterotetramer 0.033 0.011 -9999.0 0.0 0.0 53.0 53.0 GIT1 0.037 0.003 -9999.0 0.0 0.0 3.0 3.0 IGF1R 0.033 0.011 -9999.0 0.0 0.0 53.0 53.0 IGF1 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 DIAPH1 -0.132 0.276 -9999.0 0.0 -0.508 156.0 156.0 Wnt receptor signaling pathway -0.064 0.052 0.139 25.0 -9999.0 0.0 25.0 RHOA 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 RhoA/GTP -0.054 0.042 -9999.0 0.0 -0.212 17.0 17.0 CTNNA1 0.035 0.007 -9999.0 0.0 0.0 18.0 18.0 VCL -0.024 0.048 0.167 7.0 -0.234 12.0 19.0 EFNA1 0.033 0.011 -9999.0 0.0 0.0 52.0 52.0 LPP -0.03 0.048 0.183 4.0 -0.238 13.0 17.0 Ephrin A1/EPHA2 0.046 0.063 -9999.0 0.0 -0.141 41.0 41.0 SEC6/SEC8 -0.044 0.029 -9999.0 0.0 -0.145 26.0 26.0 MGAT3 -0.028 0.045 0.185 8.0 -0.197 8.0 16.0 HGF/MET 0.037 0.048 -9999.0 0.0 -0.139 15.0 15.0 HGF 0.024 0.018 -9999.0 0.0 0.0 177.0 177.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.008 0.06 -9999.0 0.0 -0.221 25.0 25.0 actin cable formation -0.04 0.103 0.31 10.0 -0.296 33.0 43.0 KIAA1543 -0.025 0.037 0.16 7.0 -0.183 8.0 15.0 KIFC3 -0.031 0.042 0.193 5.0 -0.198 8.0 13.0 NCK1 0.035 0.008 -9999.0 0.0 0.0 27.0 27.0 EXOC3 0.036 0.003 -9999.0 0.0 0.0 4.0 4.0 ACTN1 -0.027 0.051 0.187 7.0 -0.223 16.0 23.0 NCK1/GIT1 0.05 0.024 -9999.0 0.0 -0.145 6.0 6.0 mol:GDP 0.064 0.052 -9999.0 0.0 -0.139 25.0 25.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.028 0.031 0.053 22.0 -0.133 25.0 47.0 PIP5K1C -0.031 0.046 0.176 7.0 -0.212 13.0 20.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.017 -9999.0 0.0 0.0 158.0 158.0 ROCK1 -0.035 0.086 0.299 15.0 -0.278 6.0 21.0 adherens junction assembly -0.024 0.072 0.223 6.0 -0.332 14.0 20.0 IGF-1R heterotetramer/IGF1 0.05 0.062 -9999.0 0.0 -0.147 37.0 37.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.047 0.023 -9999.0 0.0 -0.145 3.0 3.0 MET 0.023 0.018 -9999.0 0.0 0.0 190.0 190.0 PLEKHA7 -0.028 0.031 0.053 22.0 -0.133 25.0 47.0 mol:GTP 0.072 0.053 -9999.0 0.0 -0.13 25.0 25.0 establishment of epithelial cell apical/basal polarity -0.039 0.039 0.121 12.0 -0.187 10.0 22.0 cortical actin cytoskeleton stabilization 0.008 0.059 -9999.0 0.0 -0.22 25.0 25.0 regulation of cell-cell adhesion -0.024 0.047 0.165 7.0 -0.23 12.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.008 0.06 -9999.0 0.0 -0.221 25.0 25.0