rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(1), EP300(6), HIF1A(3), JUN(1), NOS3(1), VHL(150)	7504580	162	151	108	8	2	15	18	39	88	0	9.28e-08	1.89e-15	7.86e-13
2	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF1(1), EIF2B1(2), EIF2B2(1), EIF2B5(2), EIF2S1(1), EIF2S2(1), ELAVL1(1), FLT1(3), FLT4(4), HIF1A(3), KDR(5), NOS3(1), PIK3CA(14), PIK3R1(1), PTK2(1), PXN(2), SHC1(2), VHL(150)	14983008	195	165	140	17	7	18	26	53	91	0	2.86e-06	2.55e-15	7.86e-13
3	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(4), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(2), ANAPC7(1), CDC16(2), CDC20(1), CDC23(2), CDC27(5), CUL1(3), CUL2(1), CUL3(2), FBXW11(1), FBXW7(4), FZR1(1), SKP2(1), SMURF1(1), SMURF2(2), TCEB1(1), UBA1(1), UBE2D1(2), UBE2D2(1), UBE2D3(1), UBE2E2(1), VHL(150), WWP1(1), WWP2(1)	17820449	196	165	142	21	4	19	31	48	94	0	2.67e-05	5.22e-15	1.07e-12
4	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(1), AKT2(2), AKT3(2), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(14), PIK3CD(1), PTEN(16), PTK2B(2), RBL2(3), SHC1(2), SOS1(4)	8973555	50	45	49	5	3	5	19	14	9	0	0.00124	0.000263	0.0405
5	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(1), AKT2(2), AKT3(2), CDKN1A(1), ELK1(1), MAP2K1(1), NGFR(1), NTRK1(2), PIK3CA(14), PIK3CD(1), SHC1(2), SOS1(4)	7184719	32	31	31	2	2	3	13	13	1	0	0.00292	0.000760	0.0936
6	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(11), CR2(1), HLA-DRA(1), ITGAL(3), ITGB2(1), PTPRC(6)	6737962	24	23	21	2	2	0	2	11	9	0	0.0913	0.0135	1.000
7	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(3), GOT1(1), GOT2(3), TAT(1), TYR(1)	2063429	9	9	9	1	1	0	5	1	2	0	0.205	0.0178	1.000
8	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(2), NR1I3(1), PTGS2(4)	2332448	9	9	9	1	1	0	1	5	2	0	0.350	0.0294	1.000
9	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ5(2), COQ6(1), NDUFA13(3), NDUFB11(1)	1778759	7	7	7	0	2	0	1	3	1	0	0.153	0.0456	1.000
10	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(2), CTH(1), GOT1(1), GOT2(3), LDHB(1), LDHC(2), MPST(2)	3003190	12	12	12	2	2	0	4	3	3	0	0.330	0.0510	1.000
11	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(2), CARS2(3), CTH(1), GOT1(1), GOT2(3), LDHAL6B(1), LDHB(1), LDHC(2), MPST(2), SULT1C2(1), SULT4A1(1)	5521164	18	18	18	2	2	1	5	5	5	0	0.144	0.0518	1.000
12	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(2), GGT1(1), SHMT1(2), SHMT2(2)	1851827	7	7	7	1	0	0	3	1	3	0	0.379	0.0557	1.000
13	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), GOT2(3), TAT(1)	1153972	5	5	5	1	1	0	3	0	1	0	0.419	0.0560	1.000
14	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(5), EGF(3), EGFR(4), HGS(3), TF(1), TFRC(2)	5644686	18	18	18	2	2	2	6	5	3	0	0.103	0.0640	1.000
15	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(2), CD4(1), HLA-DRA(1)	1044308	4	4	4	0	1	1	0	1	1	0	0.421	0.0830	1.000
16	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(2), EPX(1), MPO(2), PRDX1(1), PRDX5(1), PRDX6(1), SHMT1(2), SHMT2(2), TPO(2)	5198189	15	15	15	1	1	2	5	5	2	0	0.0557	0.0892	1.000
17	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(3), ATG7(4), BECN1(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), PIK3C3(4), PIK3R4(7), PRKAA1(1), ULK1(1), ULK2(2), ULK3(2)	9349525	33	32	33	4	3	1	5	17	7	0	0.0769	0.0907	1.000
18	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(4), PDXP(1), PSAT1(2)	2127752	7	7	7	0	2	0	0	3	2	0	0.111	0.0942	1.000
19	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(2), CD3E(1), CD3G(1), CD4(1)	1411493	5	5	5	0	1	2	0	2	0	0	0.254	0.0978	1.000
20	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(2), FMOD(2), LUM(2)	1589276	6	6	6	0	0	0	3	2	1	0	0.147	0.109	1.000
21	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), CPS1(5), GLS(1), GLUD1(2), GOT1(1)	3418789	10	10	10	1	0	0	6	2	2	0	0.115	0.132	1.000
22	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(2), EPX(1), MPO(2), MTHFR(1), PRDX6(1), SHMT1(2), SHMT2(2), TPO(2)	5115216	14	14	14	1	1	1	5	5	2	0	0.0745	0.142	1.000
23	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), GBA3(2), MPO(2), PRDX1(1), PRDX5(1), PRDX6(1), TPO(2), TYR(1)	4242452	11	11	11	0	1	2	5	2	1	0	0.0285	0.144	1.000
24	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(1), CD3G(1), CD4(1), FYN(1), HLA-DRA(1), PTPRC(6), ZAP70(2)	3990851	13	11	13	0	1	2	0	7	3	0	0.0951	0.150	1.000
25	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTR2(2), ACTR3(1), ARPC2(1), ARPC3(1), CDC42(2), WASF1(2), WASL(5)	3565740	14	13	14	2	0	3	4	7	0	0	0.173	0.153	1.000
26	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(1), FARSB(1), GOT1(1), GOT2(3), PAH(3), TAT(1), YARS(1)	3828103	11	11	11	1	1	0	3	5	2	0	0.181	0.162	1.000
27	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(3), MTMR2(1), MTMR6(2), NFS1(2)	2827611	8	8	8	1	1	0	2	3	2	0	0.263	0.164	1.000
28	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(2), CD4(1), CD80(1), HLA-DRA(1)	1747283	5	5	5	0	1	1	0	2	1	0	0.358	0.176	1.000
29	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1), CD3G(1)	499769	2	2	2	0	0	1	0	1	0	0	0.566	0.184	1.000
30	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), GOT1(1), GOT2(3), PAH(3), TAT(1), YARS(1)	3637448	10	10	10	1	1	0	3	4	2	0	0.207	0.197	1.000
31	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(1), EIF2B5(2), EIF2S1(1), EIF2S2(1), EIF4E(1), GSK3B(1), IGF1(1), IGF1R(1), INPPL1(1), PDK2(1), PIK3CA(14), PIK3R1(1), PPP2CA(1), PTEN(16), RPS6KB1(2)	8676039	45	40	44	9	0	4	16	16	9	0	0.0649	0.205	1.000
32	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), EPHX2(1), RDH11(2)	2127755	6	6	6	1	1	1	1	3	0	0	0.448	0.207	1.000
33	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD34(2), CD3E(1), CD3G(1), CD4(1), IL3(1), KITLG(2)	2739311	8	8	8	1	1	1	0	6	0	0	0.431	0.221	1.000
34	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(6), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAR2B(2)	4423565	12	12	12	0	2	1	4	5	0	0	0.0257	0.225	1.000
35	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(1), SRP19(1), SRP54(1), SRP68(3), SRP72(1), SRP9(1)	3292285	9	9	9	1	0	1	5	3	0	0	0.177	0.230	1.000
36	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(2), AASDHPPT(1), AASS(5)	3060096	9	9	9	2	0	1	1	3	4	0	0.683	0.245	1.000
37	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(3), EGFR(4), ERBB3(5), NRG1(2), UBE2D1(2)	4519374	16	16	16	3	2	1	7	1	5	0	0.241	0.246	1.000
38	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(1), AASS(5)	2077732	7	7	7	2	0	1	0	3	3	0	0.786	0.246	1.000
39	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(1), ALPP(3), ALPPL2(1), DHFR(1), FPGS(1), GGH(1)	2902656	10	8	10	1	1	1	1	6	1	0	0.222	0.251	1.000
40	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(2), CD3E(1), CD3G(1), CD4(1), ITGAL(3), ITGB2(1), PTPRC(6)	4967899	15	14	15	2	2	2	1	8	2	0	0.305	0.281	1.000
41	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), GLI2(3), GLI3(4), GSK3B(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), SHH(1), SMO(3)	7359531	20	19	20	2	5	1	4	10	0	0	0.0489	0.283	1.000
42	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	317555	1	1	1	0	0	0	1	0	0	0	0.651	0.285	1.000
43	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2B(1), UBE2D1(2), UBE2D2(1), UBE2D3(1), UBE2H(2), UBE2J1(1), UBE2J2(1), UBE3A(1)	4626924	11	11	11	1	1	0	3	4	3	0	0.194	0.328	1.000
44	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(2), CD3E(1), CD3G(1), ITGAL(3), ITGB2(1), PTPRC(6)	4731782	14	13	14	2	2	2	1	7	2	0	0.337	0.333	1.000
45	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(2)	794120	2	2	2	0	0	0	1	1	0	0	0.533	0.333	1.000
46	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(2)	723135	2	2	2	1	0	1	1	0	0	0	0.791	0.335	1.000
47	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB11A(1), RAB1A(1), RAB3A(1), RAB4A(1), RAB9A(1)	1886962	5	5	5	1	0	1	2	1	1	0	0.489	0.347	1.000
48	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), GAD1(1), TPH1(3)	2673297	6	6	6	0	1	1	3	1	0	0	0.114	0.353	1.000
49	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1), BMPR1B(1), BMPR2(4)	2758419	6	6	6	1	0	0	2	2	2	0	0.498	0.397	1.000
50	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(9), ABCB11(2), ABCB4(1), ABCC1(3), ABCC3(1)	6319348	16	15	16	2	3	1	6	3	3	0	0.0919	0.403	1.000
51	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), HDAC9(2), MEF2A(2), MEF2C(2), MEF2D(1)	3527673	8	8	8	0	1	1	1	3	2	0	0.173	0.404	1.000
52	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	FYN(1), JUN(1), MAPK14(1), THBS1(5)	3236577	8	8	8	1	0	0	2	6	0	0	0.446	0.409	1.000
53	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(2), SNAP25(1)	1429502	3	3	3	1	1	0	0	0	2	0	0.672	0.425	1.000
54	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	CDKN1A(1), GRIN1(2), HIF1A(3), JAK2(5), RELA(1), SOD2(1)	5582784	13	12	13	1	0	2	3	5	3	0	0.135	0.436	1.000
55	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(1), LCMT1(1), LCMT2(2), METTL6(1), PCYT1B(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(1)	6232199	15	14	15	1	1	2	4	7	1	0	0.0938	0.444	1.000
56	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(1), JAK1(4), JAK2(5), STAT1(2)	3619489	12	11	12	3	1	1	2	4	4	0	0.576	0.455	1.000
57	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CSAD(1), GAD1(1), GGT1(1)	2524757	5	5	5	1	1	0	2	1	1	0	0.457	0.456	1.000
58	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	HBXIP(1), PTK2B(2), SHC1(2), SOS1(4), SRC(1)	3878392	10	10	10	2	1	0	6	3	0	0	0.351	0.457	1.000
59	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	HGD(2)	984657	2	2	2	1	0	0	2	0	0	0	0.751	0.472	1.000
60	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(2), HSD17B1(1), HSD17B4(1), HSD17B7(2), HSD3B1(1)	3583146	9	9	8	2	1	3	3	2	0	0	0.297	0.481	1.000
61	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(1), EHHADH(2), HADHA(1)	2121564	4	4	4	0	1	0	3	0	0	0	0.197	0.483	1.000
62	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST3GAL5(1), ST6GALNAC2(2), ST8SIA1(1)	2483358	6	6	6	1	0	0	1	5	0	0	0.515	0.497	1.000
63	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), DRD2(1), GRM1(4), PLCB1(1), PPP1R1B(1), PPP2CA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2)	7058817	15	15	15	1	4	0	1	9	1	0	0.0840	0.501	1.000
64	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1), CYP2C9(1)	883981	2	2	2	1	0	0	1	1	0	0	0.813	0.532	1.000
65	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(1), HS3ST3A1(1), XYLT1(1), XYLT2(2)	2928434	6	6	6	1	1	0	3	2	0	0	0.298	0.545	1.000
66	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(1), HS3ST3A1(1), XYLT1(1), XYLT2(2)	2928434	6	6	6	1	1	0	3	2	0	0	0.298	0.545	1.000
67	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(1), EHHADH(2), HADH(1), HADHA(1), HSD17B4(1), SIRT1(2), SIRT7(1), VNN2(2)	5218328	11	11	11	2	1	2	5	2	1	0	0.222	0.553	1.000
68	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(1), CNR2(1), DNMT1(5), MTNR1B(1), PTGER2(1), PTGFR(1), PTGIR(1), TBXA2R(1)	4960822	12	12	12	2	2	1	3	5	1	0	0.247	0.554	1.000
69	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(5), FH(1), IDH1(2), MDH1(2), SDHB(1)	3900866	11	11	11	3	1	1	3	5	1	0	0.516	0.557	1.000
70	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP2(16), RANGAP1(1)	3693147	19	18	18	5	2	2	7	7	1	0	0.318	0.565	1.000
71	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ECHS1(1), EHHADH(2), GCDH(1), HADHA(1), SDHB(1)	3424915	6	6	6	0	2	0	4	0	0	0	0.0928	0.566	1.000
72	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(1), JUN(1), MAPK3(1), POLR2A(5), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2)	5643102	14	13	14	2	4	1	4	4	1	0	0.142	0.569	1.000
73	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLS2(1), GLUD1(2)	1992616	4	4	4	1	0	0	3	1	0	0	0.534	0.576	1.000
74	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), DHFR(1), HPRT1(1), IMPDH1(2), MTHFD2(1), POLB(2), POLD1(3), POLG(2), PRPS2(2), RRM1(1)	5540011	16	16	16	3	2	1	5	7	1	0	0.229	0.577	1.000
75	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(1), GH1(1), GHR(1), PIK3CA(14), PIK3R1(1), PPP2CA(1), RELA(1)	6184782	20	20	19	4	0	2	8	9	1	0	0.208	0.588	1.000
76	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(1), HADH(1), HADHA(1), HADHB(1), HSD17B4(1), MECR(1)	3742101	6	6	6	1	1	3	2	0	0	0	0.219	0.597	1.000
77	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25A(1), CDC25C(2), SHH(1), XPO1(5)	3843234	10	9	10	2	0	0	4	5	1	0	0.417	0.601	1.000
78	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(1), GABRA3(1), GABRA4(3), GABRA5(2), GABRA6(1), PRKCE(4)	3483596	12	11	11	4	0	3	2	3	4	0	0.586	0.607	1.000
79	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	748011	1	1	1	1	0	0	0	1	0	0	0.944	0.618	1.000
80	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX3(3), ELOVL2(1), ELOVL5(1), FADS2(2), FASN(3), HADHA(1), PECR(2)	6310952	13	12	13	2	3	2	4	4	0	0	0.146	0.621	1.000
81	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(2), CTH(1), DNMT1(5), DNMT3A(4), DNMT3B(1), MARS(2), MTR(1)	7682844	16	16	16	2	2	2	5	5	2	0	0.122	0.629	1.000
82	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(2), CALM2(1), CAMK1(1), CAMK2D(1), CAMK2G(2), CAMKK1(1), CAMKK2(1), SYT1(1)	5112305	10	10	10	0	1	0	3	5	1	0	0.0831	0.632	1.000
83	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	HLA-DRA(1), IL3(1)	1331170	2	2	2	1	0	0	0	1	1	0	0.945	0.648	1.000
84	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(4), EP300(6), NCOA3(4), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), RARA(4)	9091041	24	24	24	4	2	2	8	11	1	0	0.112	0.660	1.000
85	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ARG1(1), GLS(1), GLUD1(2)	2449544	4	4	4	0	0	0	3	0	1	0	0.198	0.678	1.000
86	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(2), TGDS(1), UXS1(1)	1724726	5	5	5	2	0	0	2	3	0	0	0.797	0.680	1.000
87	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	SPCS1(2)	1362474	2	2	2	1	0	0	1	1	0	0	0.811	0.686	1.000
88	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	CTH(1), MUT(2)	2155409	3	3	3	0	1	0	1	0	1	0	0.460	0.697	1.000
89	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(1), BCAR1(2), ITGB1(2), MAPK1(1), MAPK3(1), PDK2(1), PIK3CA(14), PIK3R1(1), PTEN(16), PTK2(1), SHC1(2), SOS1(4)	8522305	46	41	45	10	2	4	16	15	9	0	0.103	0.702	1.000
90	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(2), ACTR3(1), ARPC2(1), ARPC3(1), CDC42(2), PAK1(1), PDGFRA(6), PIK3CA(14), PIK3R1(1), WASL(5)	5877261	34	33	33	9	0	3	13	17	1	0	0.306	0.706	1.000
91	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT1(1), AKT2(2), AKT3(2), CDKN2A(3), DAPP1(1), GSK3A(1), GSK3B(1), IARS(2), INPP5D(1), PDK1(1), PIK3CA(14), PPP1R13B(3), PTEN(16), RPS6KA1(2), RPS6KA2(1), RPS6KB1(2), SHC1(2), SOS1(4), SOS2(1), TEC(3), YWHAE(2)	15940631	66	57	65	11	4	5	22	21	14	0	0.0176	0.716	1.000
92	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(1), CSNK1A1(1), GSK3B(1), MAPT(2), PPP2CA(1)	4150242	7	7	7	0	0	1	1	2	3	0	0.268	0.716	1.000
93	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(3), GALNS(1), GLB1(4), GNS(1), GUSB(2), HEXA(3), IDS(3), IDUA(1), LCT(1)	6313119	19	17	19	4	4	0	6	7	2	0	0.256	0.720	1.000
94	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), EIF4E(1), FBL(1), LDHB(1), LDHC(2), MAPK14(1), NCL(2)	3896897	11	11	11	3	0	0	5	4	2	0	0.552	0.721	1.000
95	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	LCMT1(1), LCMT2(2), METTL6(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(1)	6625297	13	12	13	0	1	1	4	6	1	0	0.0310	0.726	1.000
96	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), MIOX(2)	3770155	8	8	8	2	0	0	3	2	3	0	0.470	0.729	1.000
97	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IL15(1), IL16(5), IL3(1), LTA(1)	4377011	9	9	9	2	1	0	3	5	0	0	0.462	0.735	1.000
98	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1)	921741	1	1	1	1	0	0	0	1	0	0	0.937	0.742	1.000
99	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(1), NDUFA8(1), NDUFB6(1), NDUFS1(3), NDUFS2(1)	3056191	7	7	7	2	1	0	0	6	0	0	0.703	0.756	1.000
100	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDKN1A(1), CHEK1(1), NEK1(2)	3157229	5	5	5	1	0	0	2	2	1	0	0.557	0.759	1.000
101	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(2), JAK1(4), JAK2(5), TYK2(3)	4613052	14	13	14	4	2	1	3	5	3	0	0.598	0.759	1.000
102	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(2), JAK1(4), JAK2(5), TYK2(3)	4613052	14	13	14	4	2	1	3	5	3	0	0.598	0.759	1.000
103	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(3), GALNS(1), GLB1(4), GNS(1), GUSB(2), HEXA(3), HGSNAT(3), HPSE(1), HPSE2(1), HYAL2(1), IDS(3), IDUA(1), LCT(1), SPAM1(5)	9027117	30	26	30	5	6	1	9	12	2	0	0.0831	0.759	1.000
104	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(1), MAPK1(1), MAPK3(1), MAPK7(1), MEF2A(2), MEF2C(2), MEF2D(1), NTRK1(2), PIK3CA(14), PIK3R1(1), RPS6KA1(2), SHC1(2)	8365365	30	29	29	6	5	4	9	10	2	0	0.146	0.774	1.000
105	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(2), CALM2(1), DLG4(1), GRIN1(2), GRIN2A(3), GRIN2B(11), NOS1(7), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), SYT1(1)	11252255	37	36	37	7	6	1	11	19	0	0	0.101	0.776	1.000
106	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(4), ANKRD1(2), DUSP14(1), EIF4E(1), HBEGF(1), IFRD1(2), NR4A3(2), WDR1(1)	4786872	14	14	14	4	0	1	6	4	3	0	0.541	0.780	1.000
107	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(7), CPT1A(1), LEPR(1), PRKAA1(1), PRKAG1(1), PRKAG2(1)	6358848	12	11	12	2	0	2	4	3	3	0	0.183	0.784	1.000
108	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ECHS1(1), EHHADH(2), HADHA(1), HADHB(1)	3657479	5	5	5	1	1	0	4	0	0	0	0.346	0.784	1.000
109	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(1), GBA3(2), GGT1(1), SHMT1(2), SHMT2(2)	2472863	8	8	8	5	0	0	3	2	3	0	0.923	0.785	1.000
110	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), B3GNT1(1), GCNT2(3), ST8SIA1(1)	2694190	6	6	6	2	0	0	3	2	1	0	0.654	0.790	1.000
111	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(1), MAP2K1(1), MAPK1(1), MAPK3(1), NGFR(1)	3634248	5	5	5	1	2	2	0	1	0	0	0.455	0.795	1.000
112	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3E(1), CD3G(1), ITGAL(3), ITGB2(1)	3838757	8	8	8	2	1	1	2	4	0	0	0.552	0.796	1.000
113	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(4), AOC2(1), AOC3(1), CES1(2), ESD(1)	2662151	9	8	9	3	0	1	2	6	0	0	0.632	0.803	1.000
114	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	CHAT(2), DBH(2), DDC(3), GAD1(1), MAOA(1), PAH(3), SLC18A3(2), TPH1(3)	6384604	17	16	17	4	2	1	6	7	1	0	0.306	0.807	1.000
115	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	SQLE(1)	1418722	1	1	1	1	0	1	0	0	0	0	0.899	0.810	1.000
116	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	OXCT1(1)	1483753	1	1	1	1	0	0	0	0	1	0	0.947	0.814	1.000
117	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(2), TGDS(1), UXS1(1)	2183857	5	5	5	2	0	0	2	3	0	0	0.798	0.815	1.000
118	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(2), IGF1(1), IL3(1), KITLG(2), TGFB2(1)	3640733	7	7	7	2	1	0	3	3	0	0	0.591	0.816	1.000
119	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT2(2), B3GALT5(1), B3GNT5(1), ST3GAL3(1)	3159316	6	6	6	2	1	0	1	2	2	0	0.780	0.818	1.000
120	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), ENO1(1), GPI(1), PFKL(2), PGAM1(1), PGK1(2), TPI1(2)	4093113	10	9	10	3	1	1	3	4	1	0	0.570	0.828	1.000
121	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(1), BHMT(2), CTH(1), DNMT1(5), DNMT3A(4), DNMT3B(1), MARS(2), MTAP(2), MTR(1), TAT(1)	9166190	20	19	20	3	2	2	8	6	2	0	0.117	0.828	1.000
122	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	IDI2(1), SQLE(1)	1891905	2	2	2	1	0	1	0	1	0	0	0.825	0.828	1.000
123	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(4), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(1), DDC(3), EPX(1), GOT1(1), GOT2(3), HPD(1), MAOA(1), MAOB(1), MPO(2), PRDX1(1), PRDX5(1), PRDX6(1), TAT(1), TPO(2)	9685729	28	24	28	5	2	3	12	9	2	0	0.0813	0.836	1.000
124	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLD1(3), POLD2(1), POLE(4), POLG(2), POLL(1), POLQ(6)	7332253	19	19	19	4	4	1	1	10	3	0	0.367	0.843	1.000
125	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(1), EIF4A2(3), EIF4E(1), EIF4G1(5), EIF4G2(2), EIF4G3(3), MKNK1(1), PDK2(1), PIK3CA(14), PIK3R1(1), PPP2CA(1), PTEN(16), RPS6KB1(2), TSC1(4), TSC2(2)	12189748	57	48	56	10	1	6	17	22	11	0	0.0223	0.851	1.000
126	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IL4R(2), IRS1(3), JAK1(4), JAK3(2), RPS6KB1(2), SHC1(2), STAT6(1)	6531736	17	17	17	4	4	0	4	6	3	0	0.385	0.858	1.000
127	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTR2(2), ACTR3(1), ARPC2(1), ARPC3(1), NCKAP1(2), NTRK1(2), WASF1(2), WASF2(1), WASF3(1), WASL(5)	6716710	18	16	18	4	0	3	6	9	0	0	0.286	0.864	1.000
128	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXTL1(1), EXTL2(1), EXTL3(2), GLCE(2), HS2ST1(1), HS3ST2(1), HS3ST3A1(1), HS3ST5(1), HS6ST3(1), NDST1(1), NDST2(2), NDST3(1), NDST4(3)	9149031	19	19	19	3	2	2	6	8	1	0	0.121	0.866	1.000
129	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOB(1), TPI1(2)	1713725	3	3	3	4	0	1	1	0	1	0	0.988	0.885	1.000
130	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT6(1), ST3GAL3(1)	2240248	3	3	3	2	1	0	0	0	2	0	0.945	0.886	1.000
131	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(2), CD3E(1), CD3G(1), IL2RA(2), TGFB2(1), TGFBR2(1), TGFBR3(1), TOB1(1), TOB2(1)	4666113	11	11	11	3	1	3	3	4	0	0	0.464	0.889	1.000
132	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), GPR171(2), GPR39(1), GPR45(2), GPR65(1), GPR75(1), GPR81(1)	4309754	9	9	9	3	1	0	3	4	1	0	0.510	0.895	1.000
133	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CD4(1), HLA-DRA(1)	2342493	2	2	2	1	0	0	0	1	1	0	0.973	0.895	1.000
134	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(7), ACACB(4), FASN(3), OXSM(2)	6983032	16	16	16	4	2	3	4	6	1	0	0.362	0.898	1.000
135	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGT(1), AGTR1(1), AGTR2(1), CMA1(1), COL4A1(2), COL4A3(2), COL4A4(3), COL4A5(7), COL4A6(5), REN(1)	11304644	26	24	26	5	5	0	11	6	4	0	0.0955	0.902	1.000
136	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(1), MAX(3), SP1(1), SP3(1), TP53(13), WT1(3)	3105058	22	16	22	8	2	2	9	6	3	0	0.530	0.902	1.000
137	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CTH(1), GGT1(1), LCMT1(1), LCMT2(2), MARS(2), METTL6(1), PAPSS1(2), PAPSS2(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(1), SEPHS1(1), SEPHS2(1)	10994023	22	21	22	3	3	2	6	7	4	0	0.0988	0.905	1.000
138	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), MST1(1), MST1R(1)	2878073	3	3	3	0	0	0	0	2	1	0	0.666	0.909	1.000
139	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(4), CD38(1), ENPP3(2), NMNAT2(1), NNMT(1), NNT(5), NT5M(1), QPRT(1)	6391550	16	15	16	4	1	1	4	7	3	0	0.321	0.911	1.000
140	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(1), CYP11B2(2), CYP17A1(2), CYP21A2(3), HSD3B1(1)	4128119	10	10	9	3	0	4	1	5	0	0	0.579	0.912	1.000
141	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(1), CYP11B2(2), CYP17A1(2), CYP21A2(3), HSD3B1(1)	4128119	10	10	9	3	0	4	1	5	0	0	0.579	0.912	1.000
142	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(3), ARHGDIB(1), CASP1(1), CASP10(2), JUN(1)	5660688	9	9	9	2	0	0	2	4	3	0	0.709	0.912	1.000
143	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), GBA(1), GBA3(2), MPO(2), PRDX6(1), TPO(2)	3684648	9	9	9	3	1	1	5	2	0	0	0.498	0.913	1.000
144	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15B(2), ALOX5(1), GGT1(1), LTA4H(3), PLA2G6(1), PTGDS(1), PTGES(1), PTGS2(4), TBXAS1(1)	6651337	15	14	15	4	1	2	3	5	4	0	0.526	0.917	1.000
145	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), ARHGDIB(1), BIRC2(2), BIRC3(2), CASP1(1), CASP10(2), CASP2(2), CASP4(1), CASP7(1), LMNA(1)	8518937	14	14	14	2	1	1	5	6	1	0	0.239	0.919	1.000
146	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC2(2), BIRC3(2), CASP10(2), CASP7(1), SREBF1(1), SREBF2(2)	8044251	11	11	11	1	1	1	5	3	1	0	0.153	0.919	1.000
147	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(1), HLA-DRA(1), IFNA1(1), IL15(1), IL3(1), LTA(1), PDGFA(1), TGFB2(1)	5873734	8	8	8	1	0	0	2	5	1	0	0.470	0.921	1.000
148	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), DCXR(1), GUSB(2), RPE(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2A1(3), UGT2A3(4), UGT2B10(7), UGT2B11(2), UGT2B15(1), UGT2B7(2), XYLB(1)	12020690	38	34	36	9	5	3	11	15	4	0	0.162	0.921	1.000
149	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), GRIA2(1), PPP1R1B(1)	1676642	3	3	3	2	1	0	0	2	0	0	0.897	0.923	1.000
150	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(3), PON3(1), RDH11(2)	3971309	6	6	6	2	1	1	1	3	0	0	0.693	0.926	1.000
151	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(4), AMT(1), ATIC(1), DHFR(1), MTHFD1(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(2), SHMT2(2)	7871907	15	14	15	3	1	0	3	8	3	0	0.390	0.928	1.000
152	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1)	1323703	1	1	1	0	0	0	0	1	0	0	0.854	0.930	1.000
153	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(5), C5(2), C6(4), C7(2)	5594293	13	13	13	4	2	2	3	4	2	0	0.539	0.934	1.000
154	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(3), EGFR(4), MAP2K1(1), MAP3K1(3), MAPK14(1), NCOR2(3), RARA(4), THRA(3)	7609040	22	20	22	5	1	2	8	4	7	0	0.294	0.936	1.000
155	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(2), CALM2(1), CAMK1(1), CAMK2D(1), CAMK2G(2), ESRRA(1), MEF2A(2), MEF2C(2), MEF2D(1), PPP3CB(1), PPP3CC(2), SYT1(1)	8970432	17	16	17	3	2	1	5	6	3	0	0.272	0.939	1.000
156	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2)	4625912	9	9	9	3	2	0	4	2	1	0	0.558	0.943	1.000
157	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GABBR1(1), GPRC5A(1), GPRC5B(1), GPRC5C(1), GPRC5D(1), GRM1(4), GRM2(1), GRM3(2), GRM4(2), GRM5(3), GRM7(1)	9179215	20	20	20	4	2	0	4	14	0	0	0.324	0.945	1.000
158	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1)	5349255	10	10	10	3	1	0	6	3	0	0	0.476	0.948	1.000
159	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(3), NAT1(1), NAT2(1), XDH(1)	3497119	8	8	8	3	2	0	2	4	0	0	0.646	0.951	1.000
160	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(4), AMT(1), ATIC(1), DHFR(1), MTHFD1(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(2), SHMT2(2)	8345932	15	14	15	3	1	0	3	8	3	0	0.392	0.953	1.000
161	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(1), BID(1), BIRC2(2), BIRC3(2), CASP7(1)	5992369	7	7	7	1	0	1	3	3	0	0	0.333	0.954	1.000
162	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(1), RDH5(1)	1706859	3	3	3	2	0	1	1	1	0	0	0.841	0.958	1.000
163	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	MAF(1), MAP2K3(2), MAPK14(1), NFATC1(1), NFATC2(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2)	5357406	13	12	13	4	5	0	1	6	1	0	0.509	0.958	1.000
164	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(4), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH7A1(2), ALDH9A1(1), AMDHD1(2), AOC2(1), AOC3(1), CNDP1(3), DDC(3), LCMT1(1), LCMT2(2), MAOA(1), MAOB(1), METTL6(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(1), PRPS1(1), PRPS2(2), UROC1(1)	17499134	42	35	42	5	2	2	16	17	5	0	0.0109	0.959	1.000
165	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(1), DAXX(4), FAS(3)	4975857	8	8	8	2	1	0	2	5	0	0	0.528	0.959	1.000
166	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CFLAR(1)	1691533	1	1	1	1	0	0	1	0	0	0	0.884	0.959	1.000
167	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN1(1), CAPN2(1), EGF(3), EGFR(4), ITGA1(4), ITGB1(2), MAPK1(1), MAPK3(1), MYL2(1), MYLK(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), PTK2(1), PXN(2), TLN1(6)	14397042	36	33	36	6	4	3	13	12	4	0	0.0801	0.960	1.000
168	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CLOCK(3), CSNK1E(2), PER1(5)	3771033	11	11	11	4	3	2	2	2	2	0	0.551	0.961	1.000
169	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CLOCK(3), CSNK1E(2), PER1(5), PER2(3), PER3(2)	7555584	16	16	16	4	4	2	4	3	3	0	0.272	0.962	1.000
170	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(1), ADH1C(1), ADHFE1(1)	2471016	4	4	4	3	1	1	1	0	1	0	0.921	0.963	1.000
171	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(1), IL3(1)	2686202	2	2	2	1	0	0	0	2	0	0	0.924	0.967	1.000
172	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(2), HTR2C(1), PLCB1(1)	3145604	4	4	4	2	0	0	0	3	1	0	0.885	0.970	1.000
173	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCNE1(1), CDK2(1), CDK4(1), CDKN2A(3), E2F4(1), PRB1(4)	3990013	12	12	11	7	1	0	4	4	3	0	0.868	0.974	1.000
174	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP2(1), ACP5(1), ALPI(2), ALPL(1), ALPP(3), ALPPL2(1), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(1), PON3(1)	7927243	14	13	14	3	1	0	4	7	2	0	0.398	0.975	1.000
175	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP2(1), ACP5(1), ENPP3(2), FLAD1(2), TYR(1)	4263689	7	7	7	4	0	0	2	2	3	0	0.916	0.976	1.000
176	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(5), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1)	5934839	14	13	14	4	1	1	5	5	2	0	0.497	0.977	1.000
177	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(2), ALAS2(2), CPO(2), FECH(1), HBB(2)	3481691	9	9	9	4	1	0	2	4	2	0	0.834	0.977	1.000
178	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD3E(1), CD3G(1), CD4(1), IL12RB2(1), JAK2(5), STAT4(2), TYK2(3)	6486123	14	14	14	4	0	2	3	8	1	0	0.584	0.977	1.000
179	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BID(1), BIRC2(2), BIRC3(2), CASP10(2), CASP7(1), CFLAR(1), GAS2(3), LMNA(1), MAP3K14(1), RELA(1), RIPK1(2), SPTAN1(3), TNFRSF10A(1), TRADD(1)	14767058	23	21	23	3	2	3	6	8	4	0	0.0874	0.978	1.000
180	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(1), MMP2(1), RECK(2)	3304431	4	4	4	2	0	0	2	1	1	0	0.722	0.978	1.000
181	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(1), CYP11B2(2), CYP17A1(2), HSD3B1(1)	3053914	7	7	7	3	0	1	2	4	0	0	0.712	0.978	1.000
182	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(2), PAPSS2(1), SULT1A2(2), SUOX(2)	2676881	7	7	7	4	1	2	2	1	1	0	0.795	0.978	1.000
183	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(1), JAK1(4), JAK2(5), PTPRU(2), STAT1(2)	5073847	14	12	14	5	1	1	2	6	4	0	0.798	0.980	1.000
184	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(2), COL4A3(2), COL4A4(3), COL4A5(7), COL4A6(5), SLC23A1(3), SLC23A2(2), SLC2A3(3)	11259433	27	25	27	7	4	0	12	8	3	0	0.200	0.981	1.000
185	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	DNAJC3(2), EIF2S1(1), EIF2S2(1), MAP3K14(1), RELA(1), TP53(13)	4340077	19	15	19	6	2	2	10	4	1	0	0.358	0.982	1.000
186	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(1), ARFGAP3(1), ARFGEF2(5), CLTA(1), COPA(3), GBF1(6), KDELR3(1)	7101885	19	18	19	5	1	1	5	10	1	1	0.467	0.986	1.000
187	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK4(2), EIF2B5(2), EIF2S1(1), EIF2S2(1), EIF5(2), GSK3B(1)	5099171	9	9	9	3	0	1	4	4	0	0	0.677	0.987	1.000
188	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP2(1), ACP5(1), ENPP3(2), FLAD1(2), MTMR1(3), MTMR2(1), MTMR6(2), TYR(1)	6619215	13	13	13	6	0	0	3	5	5	0	0.837	0.988	1.000
189	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), CCNE1(1), CDK2(1), CUL1(3), RB1(2), SKP2(1)	3793988	9	9	9	7	0	1	4	2	2	0	0.940	0.988	1.000
190	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CDK2(1), CUL1(3), RB1(2), SKP2(1)	3801372	8	8	8	5	0	1	3	2	2	0	0.878	0.989	1.000
191	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(1), CHRNB1(1), MUSK(1), PIK3CA(14), PIK3R1(1), PTK2(1), PTK2B(2), SRC(1), TERT(3)	7197680	25	24	24	7	1	2	11	10	1	0	0.395	0.989	1.000
192	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(1), IFNAR2(1), JAK1(4), STAT1(2), STAT2(3), TYK2(3)	4776663	15	15	15	6	2	1	5	4	3	0	0.722	0.989	1.000
193	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(1), GABRA1(1), GABRA3(1), GABRA4(3), GABRA5(2), GABRA6(1), GPHN(2), NSF(2), SRC(1), UBQLN1(2)	5254233	16	16	16	5	0	4	8	3	1	0	0.451	0.989	1.000
194	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CTH(1), GGT1(1), MARS(2), PAPSS1(2), PAPSS2(1), SEPHS1(1)	5453435	8	8	8	3	2	0	2	1	3	0	0.691	0.990	1.000
195	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(10), MAP2(1), PPP2CA(1), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAR2B(2), PRKCE(4)	7992643	22	21	21	6	2	0	4	11	5	0	0.541	0.990	1.000
196	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ITPKA(1), ITPKB(2)	2694444	3	3	3	2	2	0	1	0	0	0	0.799	0.990	1.000
197	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	BDH1(1), BDH2(1), HMGCS1(1), HMGCS2(1), OXCT1(1)	3170668	5	5	5	3	0	0	1	3	1	0	0.936	0.990	1.000
198	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(1), CDC42(2), ELK1(1), MAP2K1(1), MAPK3(1), PIK3CA(14), PIK3R1(1), RALBP1(1), RELA(1)	8420663	23	23	22	6	1	3	10	7	2	0	0.305	0.990	1.000
199	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(3), AP2A1(1), CALM1(2), CALM2(1), DNM1(1), EPN1(1), PICALM(2), PPP3CB(1), PPP3CC(2), SYNJ1(4), SYNJ2(3), SYT1(1)	9535432	22	21	22	5	1	1	8	10	2	0	0.294	0.991	1.000
200	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), CS(2), MDH1(2), ME1(1), PC(1), PDHA1(1)	4060011	10	10	10	5	0	0	4	4	2	0	0.836	0.992	1.000
201	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(1), PAPSS1(2), PAPSS2(1), SULT1A1(2), SULT1A2(2), SUOX(2)	4055018	10	10	9	6	3	2	2	1	2	0	0.895	0.993	1.000
202	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	RB1(2), SP1(1), SP3(1)	2940945	4	4	4	7	0	0	3	0	1	0	0.997	0.993	1.000
203	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(2), ALAS2(2), FECH(1)	3346034	5	5	5	4	1	0	1	2	1	0	0.962	0.993	1.000
204	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(3), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(2), SHMT1(2)	6625002	12	11	12	4	1	1	3	6	1	0	0.688	0.994	1.000
205	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(3), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(2), SHMT1(2)	6625002	12	11	12	4	1	1	3	6	1	0	0.688	0.994	1.000
206	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(3), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(2), SHMT1(2)	6625002	12	11	12	4	1	1	3	6	1	0	0.688	0.994	1.000
207	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(2), LARS(1), PDHA1(1), PDHB(1)	4404428	5	5	5	3	0	0	1	2	2	0	0.934	0.994	1.000
208	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGT(1), AGTR1(1), AGTR2(1), BDKRB2(1), KNG1(2), NOS3(1), REN(1)	4380275	10	9	10	4	2	0	4	4	0	0	0.634	0.994	1.000
209	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), ADRBK2(1), CALM1(2), CALM2(1), CAMK2D(1), CAMK2G(2), CLCA2(3), CLCA4(3), CNGA4(1), CNGB1(2), PDC(1), PDE1C(2), PRKACA(1), PRKACB(1), PRKACG(2), PRKG1(2), PRKG2(3), PRKX(1)	13444322	30	28	30	6	7	1	10	9	3	0	0.104	0.994	1.000
210	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(4), APOBEC1(1), APOBEC3B(1), APOBEC4(2)	3220590	8	7	8	7	1	1	3	2	1	0	0.980	0.994	1.000
211	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	CS(2), FH(1), MDH1(2), OGDH(1), SDHA(1)	4117302	7	7	7	5	0	0	2	3	2	0	0.970	0.994	1.000
212	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(2), B3GAT2(1), B3GAT3(1), CHST11(1), CHST7(1), DSE(1), XYLT1(1), XYLT2(2)	6153990	10	10	10	3	2	0	4	3	1	0	0.501	0.995	1.000
213	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1)	3523590	6	6	6	3	0	0	3	3	0	0	0.823	0.995	1.000
214	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1)	3523590	6	6	6	3	0	0	3	3	0	0	0.823	0.995	1.000
215	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(1), AKT2(2), AKT3(2), CD19(1), CDKN2A(3), DAPP1(1), GAB1(1), ITPR1(2), ITPR2(7), ITPR3(1), LYN(1), PDK1(1), PIK3CA(14), PITX2(2), PLCG2(2), PPP1R13B(3), PREX1(6), PTEN(16), PTPRC(6), RPS6KA1(2), RPS6KA2(1), RPS6KB1(2), SAG(2), SYK(1), TEC(3), VAV1(2)	24524955	85	70	84	14	9	5	27	28	16	0	0.00370	0.995	1.000
216	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), SDHA(1), SDHB(1), SDHD(1)	2899812	5	5	5	3	1	0	1	2	1	0	0.863	0.995	1.000
217	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(4), JAK2(5), JAK3(2), MAPK1(1), MAPK3(1), STAT3(1), TYK2(3)	5194946	17	16	17	6	2	2	3	7	3	0	0.758	0.995	1.000
218	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	PLCB1(1), RELA(1)	3615455	2	2	2	3	0	0	1	0	1	0	0.973	0.996	1.000
219	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHAT(2), PDHA1(1), SLC18A3(2)	3091388	5	5	5	3	1	0	0	4	0	0	0.899	0.996	1.000
220	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT5(1), ST3GAL1(1), ST3GAL3(1)	3454798	4	4	4	3	0	0	2	1	1	0	0.920	0.996	1.000
221	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(4), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), AOC2(1), AOC3(1), CNDP1(3), DDC(3), MAOA(1), MAOB(1), PRPS1(1), PRPS2(2)	10778455	26	23	26	6	1	1	11	11	2	0	0.258	0.996	1.000
222	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(3), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(2), SHMT1(2)	7051363	12	11	12	4	1	1	3	6	1	0	0.683	0.997	1.000
223	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT1(1), B3GNT2(2), B3GNT3(1), B3GNT5(1), FUT6(1), GCNT2(3), ST8SIA1(1)	7079122	11	10	11	3	1	0	6	3	1	0	0.437	0.997	1.000
224	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3E(1), CD3G(1), CD4(1), CREBBP(4), CSK(2), GNAS(3), GNB1(2), HLA-DRA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), PTPRC(6), ZAP70(2)	10116848	30	26	30	7	3	2	7	15	3	0	0.386	0.997	1.000
225	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3E(1), CD3G(1), CD4(1), CREBBP(4), CSK(2), GNAS(3), GNB1(2), HLA-DRA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), PTPRC(6), ZAP70(2)	10116848	30	26	30	7	3	2	7	15	3	0	0.386	0.997	1.000
226	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALT5(1), GBGT1(2), HEXA(3), ST3GAL1(1), ST8SIA1(1)	4715338	8	8	8	3	2	0	1	5	0	0	0.761	0.997	1.000
227	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(2), RIPK1(2), TNFRSF1A(2), TRADD(1)	3721039	8	7	8	4	0	1	5	1	1	0	0.758	0.997	1.000
228	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), JAK1(4), PTPRU(2), STAT1(2), STAT2(3), TYK2(3)	5509780	15	15	15	8	2	1	4	5	3	0	0.912	0.997	1.000
229	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT10(2), GALNT4(1), GALNT7(3), GALNT8(3), GALNT9(1), GCNT1(2), ST3GAL1(1), WBSCR17(4)	6330035	18	18	18	8	2	1	5	6	4	0	0.886	0.997	1.000
230	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(2), CD3E(1), CD3G(1), CD80(1), CD86(1), HLA-DRA(1), PIK3CA(14), PIK3R1(1), PTPN11(1)	5607184	23	23	22	7	1	4	7	9	2	0	0.494	0.997	1.000
231	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(5), CS(2), DLD(4), DLST(2), FH(1), IDH1(2), IDH3B(2), MDH1(2), PC(1), PCK1(2), SDHA(1), SDHB(1), SUCLG1(2), SUCLG2(1)	9016608	28	27	28	9	2	1	8	12	5	0	0.602	0.997	1.000
232	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(2), AASDHPPT(1), AASS(5), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), BBOX1(1), DLST(2), DOT1L(3), ECHS1(1), EHHADH(2), EHMT1(1), EHMT2(2), GCDH(1), HADHA(1), PLOD2(3), PLOD3(2), SHMT1(2), SHMT2(2), TMLHE(1)	16336633	39	35	39	8	5	3	11	11	9	0	0.134	0.997	1.000
233	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), DCXR(1), GUSB(2), RPE(1), UCHL3(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2B15(1)	7739282	20	17	20	6	2	3	8	4	3	0	0.374	0.997	1.000
234	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	GREB1(6), MTA1(1), MTA3(1)	4849023	8	7	8	3	0	0	1	7	0	0	0.830	0.997	1.000
235	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADHFE1(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1)	5863437	11	10	11	5	1	1	3	3	3	0	0.796	0.997	1.000
236	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(2), CD86(1), HLA-DRA(1), IFNGR1(1), IL12RB2(1), IL2RA(2), IL4R(2)	5584435	10	10	10	4	2	1	1	4	2	0	0.777	0.998	1.000
237	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	ESCO1(2), MYST3(6), MYST4(3), PNPLA3(1), SH3GLB1(1)	7282270	13	13	13	4	2	0	4	7	0	0	0.536	0.998	1.000
238	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(2), PSMB5(1), PSMB7(1)	3834059	9	8	9	5	0	0	3	5	1	0	0.937	0.998	1.000
239	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(1), ITPKA(1), PDE1B(2), PLCB1(1), PLCB2(1)	4889322	6	6	6	4	1	0	2	1	2	0	0.911	0.998	1.000
240	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(3), ACO1(5), ACSS1(2), ACSS2(3), FH(1), IDH1(2), MDH1(2)	5827481	18	17	18	7	1	1	6	7	3	0	0.743	0.998	1.000
241	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(2), F5(5), FGA(2), FGB(1), FGG(2), PROC(2), PROS1(5), TFPI(1)	7200982	20	19	20	7	2	0	6	8	4	0	0.698	0.999	1.000
242	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), HMGCR(1), HMGCS1(1), LSS(1), PMVK(1), SC4MOL(1), SC5DL(1), SQLE(1)	5843787	8	8	8	3	0	1	0	7	0	0	0.794	0.999	1.000
243	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(4), EP300(6), IKBKB(1), MAP2K3(2), MAP3K14(1), MAP3K7(2), MAPK14(1), RELA(1), TGFBR2(1), TLR2(1)	13036750	20	19	20	4	1	1	8	9	1	0	0.233	0.999	1.000
244	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	GBGT1(2), HEXA(3), ST3GAL1(1), ST8SIA1(1)	4443749	7	7	7	3	1	0	1	5	0	0	0.838	0.999	1.000
245	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(2), B3GNT7(1), CHST4(2), ST3GAL1(1), ST3GAL3(1)	5473470	8	8	8	3	0	0	6	1	1	0	0.584	0.999	1.000
246	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	MAP2K1(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(1), NSMAF(2), RELA(1), RIPK1(2), SMPD1(1), TNFRSF1A(2), TRADD(1)	9044993	16	16	16	9	1	3	4	2	6	0	0.863	0.999	1.000
247	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(4), JAK2(5), JAK3(2), PIAS1(2), PIAS3(1), PTPRU(2)	6132797	16	13	16	5	1	2	3	7	3	0	0.686	0.999	1.000
248	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(1), AKT2(2), AKT3(2), IARS(2), IL4R(2), INPP5D(1), JAK1(4), JAK2(5), JAK3(2), PIK3CA(14), PPP1R13B(3), RPS6KB1(2), SHC1(2), SOS1(4), SOS2(1), SRC(1), STAT6(1), TYK2(3)	16276054	52	48	51	11	4	3	17	20	8	0	0.167	0.999	1.000
249	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	HMOX1(2), JAK1(4), STAT1(2), STAT3(1), STAT5A(2)	5371872	11	11	11	5	1	1	3	4	2	0	0.845	0.999	1.000
250	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(2), ACTR3(1), AKT1(1), AKT2(2), AKT3(2), ARHGEF11(2), CDC42(2), INPPL1(1), ITPR1(2), ITPR2(7), ITPR3(1), LIMK1(2), MYLK(3), MYLK2(2), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PDK1(1), PIK3CA(14), PIK3CD(1), PIK3CG(5), PIK3R1(1), PITX2(2), PPP1R13B(3), PTEN(16), RACGAP1(2), ROCK1(3), ROCK2(3), SAG(2), WASF1(2), WASL(5)	31022921	98	81	97	18	7	10	34	33	14	0	0.00346	0.999	1.000
251	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	NOTCH1(4)	4096062	4	4	4	4	1	0	1	1	1	0	0.971	0.999	1.000
252	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(1), CALM1(2), CALM2(1), CAMK2D(1), CAMK2G(2), F2(2), FYN(1), GNA11(1), GNAI1(2), GNB1(2), JAK2(5), MAP2K1(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(1), MAPT(2), MYLK(3), PTK2B(2), SHC1(2), SOS1(4), STAT1(2), STAT3(1), STAT5A(2), SYT1(1)	18364053	45	38	45	9	6	4	14	18	3	0	0.0903	0.999	1.000
253	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(1), PIK3CA(14), PIK3R1(1), PLCB1(1), VAV1(2)	5606642	19	19	18	9	1	3	7	6	2	0	0.813	0.999	1.000
254	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR4(1), CD28(2), CD4(1), CXCR4(1), IFNGR1(1), IL12RB2(1), IL4R(2), TGFB2(1)	8798869	10	10	10	3	2	2	2	3	1	0	0.483	0.999	1.000
255	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(1), GSS(1), NOX1(2), RELA(1), XDH(1)	4390038	6	6	6	3	0	0	2	4	0	0	0.806	0.999	1.000
256	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(2), PSMB5(1), PSMB7(1), RPN1(1), RPN2(2), UBE3A(1)	5700557	13	12	13	6	0	0	3	8	2	0	0.918	0.999	1.000
257	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), IL3(1), IL3RA(1), JAK2(5), MAP2K1(1), MAPK3(1), PTPN6(1), SHC1(2), SOS1(4), STAT5A(2)	7781068	19	19	19	6	2	3	5	8	1	0	0.528	0.999	1.000
258	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD33(1), CD7(1), IFNA1(1), IL3(1), ITGAX(2), TLR2(1), TLR4(1), TLR7(1)	8173001	12	12	12	4	2	0	4	5	1	0	0.567	1.000	1.000
259	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), HMGB2(1), TOP2A(1), TOP2B(1)	4233288	4	4	4	2	0	0	2	2	0	0	0.821	1.000	1.000
260	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	IKBKAP(3), IKBKB(1), LTA(1), MAP3K1(3), MAP3K14(1), RELA(1), RIPK1(2), TANK(1)	9866591	13	13	13	4	1	0	4	3	5	0	0.514	1.000	1.000
261	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K7(1), MAPK1(1), MAPK10(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), NFKBIL2(2), PIK3CA(14), PIK3CD(1), PIK3R1(1), SYT1(1), TRAF5(2)	14826086	35	34	34	8	4	4	9	15	3	0	0.162	1.000	1.000
262	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BCL10(1), BID(1), CASP8AP2(4), CES1(2)	4995536	9	8	9	5	0	2	2	4	1	0	0.895	1.000	1.000
263	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	JAK1(4), JAK2(5), JAK3(2), PIAS3(1), PTPRU(2), SRC(1), STAT3(1)	6761607	16	14	16	7	1	1	3	8	3	0	0.908	1.000	1.000
264	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(5), C5(2), C6(4), C7(2), ITGA4(2), ITGAL(3), ITGB1(2), ITGB2(1), SELP(2), SELPLG(1), VCAM1(2)	10973335	26	26	26	8	3	3	8	8	4	0	0.430	1.000	1.000
265	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	IKBKAP(3), IKBKB(1), MAP3K1(3), MAP3K14(1), RELA(1)	7972844	9	9	9	4	0	0	3	2	4	0	0.749	1.000	1.000
266	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(2), AGT(1), AGTR1(1), AGTR2(1), ANPEP(3), CMA1(1), CTSA(2), ENPEP(3), LNPEP(2), MAS1(1), MME(1), REN(1)	9322963	21	20	21	6	2	2	9	6	2	0	0.419	1.000	1.000
267	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS(2), IARS2(2), ILVBL(1), LARS(1), PDHA1(1), PDHB(1), VARS(2), VARS2(3)	8156296	13	12	13	6	0	0	4	5	4	0	0.848	1.000	1.000
268	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(1), EPHB1(1), FYN(1), ITGA1(4), ITGB1(2), L1CAM(3), LYN(1), RAP1B(2), SELP(2)	6922781	17	15	17	6	1	3	6	6	1	0	0.632	1.000	1.000
269	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(4), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(1), DDC(3), EPX(1), ESCO1(2), GOT1(1), GOT2(3), HPD(1), MAOA(1), MAOB(1), MPO(2), MYST3(6), MYST4(3), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(1), TPO(2)	15057565	39	35	39	9	4	2	16	15	2	0	0.137	1.000	1.000
270	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(1), EIF4A2(3), EIF4E(1), EIF4G1(5), EIF4G2(2), EIF4G3(3), GHR(1), IRS1(3), MAPK1(1), MAPK14(1), MAPK3(1), MKNK1(1), PABPC1(3), PDK2(1), PIK3CA(14), PIK3R1(1), PTEN(16), RPS6KB1(2)	12351835	60	51	59	15	2	7	17	24	10	0	0.146	1.000	1.000
271	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(2), EGF(3), EGFR(4), MAP2K1(1), MAPK1(1), MAPK3(1), PTPRB(4), RASA1(2), SHC1(2), SOS1(4), SPRY2(2), SPRY4(1), SRC(1)	11003331	28	26	28	8	3	2	14	6	3	0	0.378	1.000	1.000
272	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(2), DPYD(1), DPYS(1), ENPP3(2), PANK1(1), PANK2(2), PANK3(1), UPB1(1)	6140217	11	10	11	9	1	0	3	5	2	0	0.976	1.000	1.000
273	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNAR1(1), IFNAR2(1), MAPK8(1), RELA(1), TNFSF11(1)	4882888	5	5	5	3	0	0	3	2	0	0	0.861	1.000	1.000
274	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(2), ITGA4(2), ITGAL(3), ITGB1(2), ITGB2(1), SELE(2)	5373022	12	12	12	5	1	0	8	2	1	0	0.641	1.000	1.000
275	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IKBKB(1), IRAK1(3), MAP3K1(3), MAP3K14(1), MAP3K7(2), RELA(1), RIPK1(2), TLR4(1), TNFRSF1A(2), TRADD(1)	10754342	17	16	17	9	1	1	5	4	6	0	0.869	1.000	1.000
276	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(2), ABCG2(1), BCHE(1), CES1(2), CES2(1), CYP3A4(1), CYP3A5(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1)	10005015	24	21	24	8	2	5	7	7	3	0	0.465	1.000	1.000
277	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), HMGCR(1), LSS(1), PMVK(1), SC5DL(1), SQLE(1)	4913479	6	6	6	3	0	1	0	5	0	0	0.880	1.000	1.000
278	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(1), GNAS(3), GNB1(2), PPP2CA(1), PRKAA1(1), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAG2(1), PRKAR1A(1), PRKAR2B(2)	6725306	16	16	16	5	2	0	3	10	1	0	0.684	1.000	1.000
279	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), GLB1(4), HEXA(3), LCT(1), SLC33A1(3), ST3GAL1(1), ST3GAL5(1), ST6GALNAC5(2), ST8SIA1(1), ST8SIA5(1)	7220801	18	17	18	6	3	0	4	9	2	0	0.682	1.000	1.000
280	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(2), CALM2(1), MAP3K1(3), NFATC1(1), NFATC2(2), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), RELA(1), SYT1(1), VIPR2(1)	12271098	21	21	21	5	5	0	5	7	4	0	0.300	1.000	1.000
281	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(5), CS(2), GRHPR(1), MDH1(2), MTHFD1(1), MTHFD2(1)	5608237	12	12	12	6	1	1	2	7	1	0	0.821	1.000	1.000
282	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(1), AKT2(2), AKT3(2), GSK3A(1), GSK3B(1), IL4R(2), IRS1(3), IRS2(1), JAK1(4), JAK3(2), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(14), PIK3CD(1), PIK3R1(1), PPP1R13B(3), SHC1(2), SOS1(4), SOS2(1), STAT6(1)	16097245	49	44	48	11	7	4	15	19	4	0	0.149	1.000	1.000
283	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	ELK1(1), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(1), NGFR(1), PIK3CA(14), PIK3R1(1), SHC1(2), SOS1(4)	8403511	27	26	26	9	2	3	10	11	1	0	0.543	1.000	1.000
284	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), ARHGEF1(1), GNA13(2), GNB1(2), MYL2(1), MYLK(3), PLCB1(1), PPP1R12B(1), ROCK1(3)	9099116	17	17	17	8	0	0	2	11	4	0	0.919	1.000	1.000
285	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(1), ADRB2(1), GNAS(3), PLCE1(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), RAP2B(1)	6458913	15	15	15	5	2	0	5	7	1	0	0.665	1.000	1.000
286	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(2), CALM2(1), CDKN1A(1), MARCKS(3), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), PPP3CB(1), PPP3CC(2), SP1(1), SP3(1), SYT1(1)	9201815	21	21	20	9	3	0	6	7	5	0	0.861	1.000	1.000
287	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), GOT1(1), GOT2(3), GPT2(1), MDH1(2), ME1(1), ME2(2), ME3(1), PGK1(2), RPE(1), TPI1(2)	7882558	17	16	17	8	1	1	9	3	3	0	0.731	1.000	1.000
288	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(1), NTRK1(2), PIK3CA(14), PIK3R1(1), SHC1(2), SOS1(4)	6836607	24	23	23	8	1	2	10	10	1	0	0.553	1.000	1.000
289	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR7(1), HMGCR(1), HSD17B7(2), IDI2(1), LSS(1), PMVK(1), SC4MOL(1), SC5DL(1), SQLE(1), TM7SF2(1)	8543218	11	11	10	4	0	1	2	7	1	0	0.765	1.000	1.000
290	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPS7(1), RPL10L(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL27(1), RPL28(2), RPL3(1), RPL30(2), RPL31(1), RPL34(1), RPL3L(1), RPL7(1), RPL9(1), RPS11(1), RPS13(1), RPS2(1), RPS21(1), RPS24(1), RPS26(2), RPS27(1), RPS29(1), RPS3(1), RPS3A(1), RPS4Y1(1)	10108851	31	30	31	8	4	2	8	14	3	0	0.349	1.000	1.000
291	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(5), CS(2), GRHPR(1), MDH1(2), MTHFD1(1), MTHFD2(1)	5876819	12	12	12	6	1	1	2	7	1	0	0.823	1.000	1.000
292	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(2), FCGR3A(1), TGFB2(1), TNFRSF1A(2)	5889850	8	8	8	6	1	0	5	1	1	0	0.919	1.000	1.000
293	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), ABP1(4), AOC2(1), AOC3(1), CES1(2), CES7(1), DDHD1(1), ESCO1(2), MYST3(6), MYST4(3), PNPLA3(1), PRDX6(1), SH3GLB1(1)	11168902	25	23	25	7	2	1	8	13	1	0	0.408	1.000	1.000
294	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(1), ACADS(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(1), HADHA(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHB(1), SDHB(1)	11322600	19	19	18	6	5	0	7	5	2	0	0.421	1.000	1.000
295	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNA1(1), IKBKB(1), IL1RAP(2), IRAK1(3), IRAK3(1), JUN(1), MAP2K3(2), MAP3K1(3), MAP3K14(1), MAP3K7(2), MAPK14(1), MAPK8(1), RELA(1), TGFB2(1)	13044849	21	19	21	5	4	0	7	5	5	0	0.278	1.000	1.000
296	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(1), AKT2(2), AKT3(2), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(1), NFKBIL2(2), PDK1(1), PHKA2(1), PIK3CB(2), PITX2(2), PLD1(3), PLD3(1)	19777186	31	28	31	6	6	2	9	11	3	0	0.0935	1.000	1.000
297	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), IKBKB(1), JUN(1), MAP3K1(3), MAP3K5(4), MAPK14(1), MAPK8(1), RELA(1), TNFRSF9(1)	8579355	14	13	14	6	0	1	3	7	3	0	0.798	1.000	1.000
298	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ALDH18A1(1), ARG1(1), CPS1(5), GLUD1(2), OTC(1), PYCR1(1), SMS(2)	7691829	14	14	14	6	1	0	7	4	2	0	0.737	1.000	1.000
299	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CASP2(2), IKBKB(1), JUN(1), LTA(1), MAP2K3(2), MAP3K1(3), MAP3K14(1), MAPK14(1), MAPK8(1), RELA(1), RIPK1(2), TANK(1), TNFRSF1A(2), TRADD(1)	10664710	21	19	21	7	2	1	5	8	5	0	0.639	1.000	1.000
300	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), GOT1(1), GOT2(3), GPT2(1), MDH1(2), ME1(1), ME3(1), PGK1(2), RPE(1), TKTL1(1), TKTL2(2), TPI1(2)	8811660	18	18	18	9	1	1	9	4	3	0	0.785	1.000	1.000
301	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), CYB5R3(2), GNE(1), HEXA(3), RENBP(2), UAP1(1)	7440957	10	9	10	6	1	1	2	4	2	0	0.907	1.000	1.000
302	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA3(1), ANXA4(1), ANXA6(1), CYP11A1(1), EDNRB(1), HPGD(1), PLA2G4A(1), PTGDS(1), PTGER2(1), PTGFR(1), PTGIR(1), PTGS2(4), TBXAS1(1)	9111411	16	16	16	7	1	1	5	6	3	0	0.768	1.000	1.000
303	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ECHS1(1), EHHADH(2), ESCO1(2), GCDH(1), HADHA(1), MYST3(6), MYST4(3), PNPLA3(1), SH3GLB1(1)	11407061	18	18	18	5	4	0	7	7	0	0	0.342	1.000	1.000
304	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAP3K14(1), MAPK14(1), MAPK8(1), RELA(1), TRAF5(2)	6410368	6	6	6	3	0	0	3	3	0	0	0.787	1.000	1.000
305	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1R(1), C1S(2), C3(5), C5(2), C6(4), C7(2)	7805566	16	16	16	6	3	2	4	5	2	0	0.701	1.000	1.000
306	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(3), JUN(1), MAP2K1(1), MAPK1(1), MAPK3(1), PLCB1(1), RELA(1)	6794927	9	9	9	5	3	3	1	1	1	0	0.793	1.000	1.000
307	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(1), ARF1(1), EEA1(5), GSK3A(1), GSK3B(1), LYN(1), PFKL(2), PFKM(1), PRKCE(4), RPS6KB1(2), VAV2(3)	11032220	23	20	22	7	1	2	6	9	5	0	0.571	1.000	1.000
308	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(1), ADSL(1), AGXT(1), CAD(2), CRAT(1), DARS(2), GAD1(1), GOT1(1), GOT2(3), GPT2(1), PC(1)	11461849	16	15	16	7	3	1	5	2	5	0	0.728	1.000	1.000
309	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(4), CD38(1), ENPP3(2), NMNAT2(1), NMNAT3(1), NNMT(1), NNT(5), NT5C1B(1), NT5C3(1), NT5M(1), QPRT(1)	9482643	19	18	19	7	1	1	5	9	3	0	0.617	1.000	1.000
310	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(2), PSMB5(1), PSMB7(1), PSMC2(1), PSMD11(1), PSMD2(1), PSMD6(1)	7007641	13	12	13	7	1	0	5	6	1	0	0.918	1.000	1.000
311	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(2), ITGA4(2), ITGAL(3), ITGAM(1), ITGB1(2), ITGB2(1), SELE(2), SELP(2)	7069153	15	15	15	6	2	1	8	3	1	0	0.594	1.000	1.000
312	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), CYP2C19(1), CYP2C9(1), ECHS1(1), EHHADH(2), ESCO1(2), HADHA(1), MYST3(6), MYST4(3), PNPLA3(1), SH3GLB1(1)	13592705	25	23	25	7	3	0	10	10	2	0	0.316	1.000	1.000
313	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(3), AGT(1), AGTR2(1), EDNRB(1), EGF(3), EGFR(4), JUN(1), RELA(1)	9012433	15	15	15	7	1	0	6	5	3	0	0.859	1.000	1.000
314	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(1), ACADS(2), ACSL1(2), ACSL3(1), ACSL4(1), CPT1A(1), EHHADH(2), HADHA(1), PECR(2), SCP2(2), SLC25A20(1)	7374640	16	15	15	8	2	2	9	2	1	0	0.626	1.000	1.000
315	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1R(1), C1S(2), C3(5), C5(2), C6(4), C7(2), C8B(1), MASP1(1)	9249616	18	18	18	6	5	2	4	5	2	0	0.579	1.000	1.000
316	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(4), EP300(6), MAPK1(1), MAPK3(1), SRC(1)	6461222	13	13	13	5	1	2	6	4	0	0	0.618	1.000	1.000
317	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(1), POLR1B(2), POLR2A(5), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(2), POLR3B(4), POLR3G(2), POLR3H(1)	10330955	23	22	21	7	2	3	10	6	2	0	0.413	1.000	1.000
318	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1R(1), C1S(2), C3(5), C5(2), C6(4), C7(2), MASP1(1), MBL2(1)	9487038	18	18	18	6	4	2	5	5	2	0	0.568	1.000	1.000
319	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2D(1), CAMK2G(2), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(1), NFAT5(3), PDE6A(2), PDE6B(1), PDE6C(2), SLC6A13(1), TF(1)	15816674	26	25	26	7	7	2	5	10	2	0	0.326	1.000	1.000
320	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(4), ACTR2(2), ACTR3(1), AKT1(1), CDC42(2), FLNA(3), FLNC(6), FSCN1(3), LIMK1(2), MYH2(6), MYLK(3), MYLK2(2), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), ROCK1(3), ROCK2(3), WASF1(2), WASL(5)	21101553	56	48	56	13	5	6	18	21	6	0	0.0994	1.000	1.000
321	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(9), AKT1(1), ATM(14), CDKN1A(1), CSNK1A1(1), FHL2(1), HIC1(1), HIF1A(3), MAPK8(1), TP53(13)	9166900	45	38	45	13	2	2	18	11	12	0	0.325	1.000	1.000
322	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP2(1), ACP5(1), ALPI(2), ALPL(1), ALPP(3), ALPPL2(1), CYP19A1(3), CYP1A1(1), CYP1A2(2), CYP2A13(3), CYP2B6(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(2), CYP2F1(1), CYP2J2(1), CYP3A4(1), CYP3A5(1), CYP3A7(1), CYP4B1(1)	12896158	30	28	30	9	5	1	9	13	2	0	0.384	1.000	1.000
323	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(3), ARSE(1), GAL3ST1(2), GALC(1), GBA(1), GLB1(4), LCT(1), NEU1(1), NEU3(1), PPAP2B(1), SMPD1(1)	10730725	17	16	17	8	0	0	5	8	4	0	0.889	1.000	1.000
324	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(2), CHIT1(2), CMAS(1), CTBS(1), CYB5R1(2), CYB5R3(2), GFPT2(2), GNE(1), HEXA(3), MTMR1(3), MTMR2(1), MTMR6(2), NAGK(2), NANS(1), RENBP(2), UAP1(1)	12629144	29	27	29	9	3	2	8	11	5	0	0.443	1.000	1.000
325	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(4), EP300(6), LPL(1), NCOA1(2), NCOA2(2), PPARG(1)	8128528	16	15	16	8	1	2	7	5	1	0	0.789	1.000	1.000
326	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	ELK1(1), IL6ST(3), JAK1(4), JAK2(5), JAK3(2), JUN(1), MAP2K1(1), MAPK3(1), PTPN11(1), SHC1(2), SOS1(4), STAT3(1)	10540593	26	25	26	9	3	2	7	11	3	0	0.718	1.000	1.000
327	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3E(1), CD3G(1), IL12RB2(1), JAK2(5), JUN(1), MAPK14(1), MAPK8(1), STAT4(2), TYK2(3)	8213744	16	15	16	6	0	2	4	9	1	0	0.762	1.000	1.000
328	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(4), ADH1A(1), ADH1B(1), ADH1C(1), ADHFE1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(1), AOX1(4), DBH(2), DCT(2), DDC(3), GOT1(1), GOT2(3), HGD(2), HPD(1), MAOA(1), MAOB(1), TAT(1), TPO(2), TYR(1)	13983878	37	32	37	10	3	3	14	12	5	0	0.307	1.000	1.000
329	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(2), DDX20(4), E2F4(1), ETS1(1), JUN(1), NCOR2(3), RBL2(3), SIN3A(2), SIN3B(2)	11484628	19	18	19	8	0	1	6	8	4	0	0.757	1.000	1.000
330	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), GLB1(4), HEXA(3), LCT(1), MAN2C1(5), NEU1(1), NEU3(1)	7309134	16	15	16	6	2	1	4	9	0	0	0.769	1.000	1.000
331	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(7), ACACB(4), ACOT12(1), ACSS1(2), ACSS2(3), AKR1B1(2), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), DLAT(2), DLD(4), GRHPR(1), HAGH(1), HAGHL(1), LDHAL6B(1), LDHB(1), LDHC(2), MDH1(2), ME1(1), ME2(2), ME3(1), PC(1), PCK1(2), PCK2(2), PDHA1(1), PDHB(1)	20565587	51	44	51	12	3	3	20	14	11	0	0.153	1.000	1.000
332	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ADH1A(1), ADH1B(1), ADH1C(1), ADHFE1(1), AKR1C4(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(1), HADHB(1), SOAT2(1), SRD5A1(1)	10231826	18	18	18	9	1	2	8	5	2	0	0.838	1.000	1.000
333	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), GLB1(4), HEXA(3), LCT(1), MAN2B2(1), MAN2C1(5), NEU1(1), NEU3(1)	9003302	17	15	17	6	2	1	4	10	0	0	0.735	1.000	1.000
334	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(1), AKT2(2), AKT3(2), BRD4(4), CBL(2), CDC42(2), CDKN2A(3), F2RL2(1), GSK3A(1), GSK3B(1), INPPL1(1), IRS1(3), IRS2(1), LNPEP(2), MAPK1(1), MAPK3(1), PARD3(3), PDK1(1), PIK3CA(14), PIK3CD(1), PIK3R1(1), PTEN(16), PTPN1(1), RPS6KA1(2), RPS6KA2(1), RPS6KB1(2), SERPINB6(1), SHC1(2), SORBS1(1), SOS1(4), SOS2(1), YWHAE(2)	26163779	81	68	80	18	6	7	26	30	12	0	0.0454	1.000	1.000
335	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX5(1), CBR1(2), CYP4F2(1), EPX(1), GGT1(1), LTA4H(3), MPO(2), PLA2G4A(1), PLA2G6(1), PRDX1(1), PRDX5(1), PRDX6(1), PTGDS(1), PTGS2(4), TBXAS1(1), TPO(2)	12256936	24	24	24	8	4	4	6	6	4	0	0.558	1.000	1.000
336	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADHFE1(1), AKR1B10(3), AKR1C4(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(1), HADHB(1), RDH11(2), SLC27A5(2), SOAT2(1), SRD5A1(1)	13995305	26	24	26	9	3	3	8	8	4	0	0.524	1.000	1.000
337	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), B4GALT5(1), DDOST(1), DPAGT1(2), MGAT3(1), MGAT4A(3), MGAT5(3), RPN1(1), RPN2(2)	8732764	15	14	15	7	3	1	4	6	1	0	0.805	1.000	1.000
338	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(2), BIRC3(2), CFLAR(1), JUN(1), MAP3K7(2), NFKBIL2(2), RALBP1(1), RIPK1(2), TNFRSF1A(2), TRADD(1)	11993169	17	15	17	9	0	2	7	5	3	0	0.904	1.000	1.000
339	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	AKT1(1), BDKRB2(1), CALM1(2), CALM2(1), CHRNA1(2), FLT1(3), FLT4(4), KDR(5), NOS3(1), PDE2A(3), PDE3A(3), PDE3B(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), PRKG1(2), PRKG2(3), RYR2(12), SLC7A1(1), SYT1(1), TNNI1(1)	18134657	55	49	55	15	13	3	14	20	5	0	0.197	1.000	1.000
340	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(1), CDC25C(2), GNAI1(2), GNAS(3), GNB1(2), MAPK1(1), MAPK3(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), RPS6KA1(2), SRC(1)	8990358	21	19	21	9	4	1	4	11	1	0	0.826	1.000	1.000
341	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	CD97(1), CRHR2(1), ELTD1(2), GHRHR(1), GIPR(1), GLP1R(1), GPR64(2), LPHN1(2), LPHN2(2), LPHN3(4), SCTR(1), VIPR1(1), VIPR2(1)	11846665	20	19	20	7	1	2	5	10	2	0	0.588	1.000	1.000
342	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	ELK1(1), JAK2(5), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(1), PTPN6(1), SHC1(2), SOS1(4), STAT5A(2)	9470400	19	18	19	9	2	3	6	7	1	0	0.839	1.000	1.000
343	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	AGT(1), AKT1(1), CALM1(2), CALM2(1), CALR(1), CAMK1(1), CREBBP(4), CSNK1A1(1), ELSPBP1(1), F2(2), GATA4(1), GSK3B(1), IGF1(1), MAP2K1(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(1), MEF2C(2), MYH2(6), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), NPPA(1), PIK3CA(14), PIK3R1(1), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), RPS6KB1(2), SYT1(1)	22314531	67	59	66	17	9	6	22	23	7	0	0.105	1.000	1.000
344	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(4), EP300(6), IKBKB(1), RELA(1), RIPK1(2), TNFRSF1A(2), TRADD(1)	9863487	17	17	17	7	0	2	9	5	1	0	0.642	1.000	1.000
345	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(4), CALM1(2), CALM2(1), CAPN2(1), EP300(6), HDAC1(1), MEF2D(1), NFATC1(1), NFATC2(2), PPP3CB(1), PPP3CC(2), SYT1(1)	10704336	23	22	23	9	4	1	7	10	1	0	0.647	1.000	1.000
346	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), CDC42(2), DAXX(4), ELK1(1), MAP3K1(3), MAP3K5(4), MAP3K7(2), MAP3K9(1), MAPK14(1), MAX(3), MEF2A(2), MEF2C(2), MEF2D(1), MKNK1(1), PLA2G4A(1), RIPK1(2), SHC1(2), STAT1(2), TGFB2(1), TRADD(1)	16188327	37	34	37	10	3	3	9	15	7	0	0.369	1.000	1.000
347	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(7), ADH5(1), AKR1B1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), DLAT(2), DLD(4), GRHPR(1), HAGH(1), HAGHL(1), LDHB(1), LDHC(2), MDH1(2), ME1(1), ME2(2), ME3(1), PC(1), PCK1(2), PDHA1(1), PDHB(1)	16271045	39	34	39	11	0	2	17	13	7	0	0.376	1.000	1.000
348	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	ELK1(1), IKBKB(1), IRAK1(3), JUN(1), MAP2K3(2), MAP3K1(3), MAP3K14(1), MAP3K7(2), MAPK14(1), MAPK8(1), RELA(1), TLR10(1), TLR2(1), TLR4(1), TLR6(1), TLR7(1)	16060809	22	19	22	8	2	0	7	8	5	0	0.595	1.000	1.000
349	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), ARSB(3), GALNS(1), GBA(1), GLB1(4), GNS(1), GUSB(2), HEXA(3), HGSNAT(3), HPSE(1), HPSE2(1), HYAL2(1), IDS(3), IDUA(1), LCT(1), MAN2B2(1), MAN2C1(5), NEU1(1), NEU3(1), SPAM1(5)	15243040	40	32	40	11	7	2	11	18	2	0	0.343	1.000	1.000
350	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(1), AKT2(2), AKT3(2), BRAF(5), FIGF(2), HIF1A(3), IGF1(1), MAPK1(1), MAPK3(1), PGF(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PRKAA1(1), RHEB(2), RICTOR(4), RPS6KA1(2), RPS6KA2(1), RPS6KA6(3), RPS6KB1(2), RPS6KB2(1), TSC1(4), TSC2(2), ULK1(1), ULK2(2), ULK3(2)	23609369	72	61	71	18	6	5	24	22	15	0	0.132	1.000	1.000
351	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADHFE1(1), ESCO1(2), MYST3(6), MYST4(3), PNPLA3(1), SH3GLB1(1)	11000260	18	18	18	7	3	1	5	8	1	0	0.710	1.000	1.000
352	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(4), ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADHFE1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(1), AOX1(4), DBH(2), DCT(2), DDC(3), ESCO1(2), GOT1(1), GOT2(3), HGD(2), HPD(1), LCMT1(1), LCMT2(2), MAOA(1), MAOB(1), METTL6(1), MYST3(6), MYST4(3), PNPLA3(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(1), SH3GLB1(1), TAT(1), TPO(2), TYR(1), TYRP1(1)	26226299	65	57	65	15	6	4	23	26	6	0	0.105	1.000	1.000
353	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(4), AGXT(1), AKR1B10(3), ALAS1(2), ALAS2(2), AMT(1), AOC2(1), AOC3(1), BHMT(2), CHKB(1), CTH(1), DAO(1), DLD(4), DMGDH(2), GARS(1), GNMT(1), MAOA(1), MAOB(1), PHGDH(1), PISD(1), PSAT1(2), RDH11(2), SARDH(2), SARS(1), SHMT1(2), SHMT2(2), TARS(1), TARS2(2)	18923535	46	43	46	12	5	4	17	16	4	0	0.191	1.000	1.000
354	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CHN1(2), LIMK1(2), MAP3K1(3), MYL2(1), MYLK(3), NCF2(1), PAK1(1), PDGFRA(6), PIK3CA(14), PIK3R1(1), PLD1(3), PPP1R12B(1), RALBP1(1), RPS6KB1(2), TRIO(5), VAV1(2), WASF1(2)	15373550	50	44	49	14	1	5	15	21	8	0	0.342	1.000	1.000
355	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(2), AKT1(1), AKT2(2), AKT3(2), APAF1(1), ATM(14), BID(1), BIRC2(2), BIRC3(2), CAPN1(1), CAPN2(1), CASP10(2), CASP7(1), CFLAR(1), CSF2RB(1), FAS(3), IKBKB(1), IL1RAP(2), IL3(1), IL3RA(1), IRAK1(3), IRAK3(1), IRAK4(1), MAP3K14(1), NTRK1(2), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKACA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), RELA(1), RIPK1(2), TNFRSF10A(1), TNFRSF1A(2), TP53(13), TRADD(1)	36977199	107	81	106	23	9	7	40	37	14	0	0.0136	1.000	1.000
356	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(1), AKT1(1), CAMK2D(1), CAMK2G(2), GNAS(3), MAPK1(1), MAPK14(1), MAPK3(1), PIK3CA(14), PIK3R1(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), RPS6KA1(2), SOS1(4)	12782134	38	36	37	11	4	3	13	17	1	0	0.425	1.000	1.000
357	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(1), AKT2(2), AKT3(2), CDC42(2), CDK2(1), CDKN2A(3), ERBB4(7), F2RL2(1), GAB1(1), GSK3A(1), GSK3B(1), IGF1(1), INPPL1(1), IRS1(3), IRS2(1), MET(5), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PARD3(3), PDK1(1), PIK3CA(14), PIK3CD(1), PPP1R13B(3), PREX1(6), PTEN(16), PTK2(1), PTPN1(1), RPS6KA1(2), RPS6KA2(1), RPS6KB1(2), SHC1(2), SOS1(4), SOS2(1), TSC1(4), TSC2(2), YWHAE(2)	34089171	107	84	106	25	7	9	35	42	14	0	0.0552	1.000	1.000
358	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), CAD(2), CPS1(5), EPRS(1), GAD1(1), GLS(1), GLS2(1), GLUD1(2), GOT1(1), GOT2(3), GPT2(1), GSS(1), QARS(1)	14608519	21	20	21	9	3	0	10	6	2	0	0.695	1.000	1.000
359	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(4), ATP6V0A1(3), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(2), ATP7B(4), COX7A2(1), NDUFA10(1), NDUFA8(1), NDUFB6(1), NDUFS1(3), NDUFS2(1), PPA2(1), SDHA(1), SDHB(1), SHMT1(2), UQCRFS1(3)	16804824	34	32	32	10	3	1	12	15	3	0	0.433	1.000	1.000
360	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(1), AKT2(2), AKT3(2), BLNK(2), CD19(1), CSK(2), EPHB2(1), ITPKA(1), ITPKB(2), LYN(1), MAP2K1(1), MAPK1(1), NFAT5(3), NFKBIL2(2), PIK3CA(14), PIK3CD(1), PIK3R1(1), PLCG2(2), PPP1R13B(3), SHC1(2), SOS1(4), SOS2(1), SYK(1), VAV1(2)	23166965	53	46	52	14	7	5	18	19	4	0	0.158	1.000	1.000
361	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(1), AGTR2(1), AVPR1A(2), AVPR2(1), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(1), CCKBR(1), CCR4(1), CCR6(1), CX3CR1(1), CXCR4(1), CXCR6(2), EDNRB(1), FPR1(2), GALR1(1), GALT(2), GPR77(1), LHCGR(1), MC2R(2), MC3R(1), MC4R(1), NPY2R(1), NTSR1(1), OPRD1(3), OPRL1(2), OPRM1(3), SSTR1(1), SSTR3(1), SSTR4(1), TACR1(1), TACR3(3), TRHR(2)	22939122	48	44	48	13	11	6	12	16	3	0	0.158	1.000	1.000
362	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(1), GTF2A2(1), GTF2E2(2), GTF2F1(1), GTF2F2(1), GTF2H1(1), GTF2I(1), GTF2IRD1(1), TAF1(6), TAF1L(7), TAF2(1), TAF4(1), TAF4B(3), TAF5(2), TAF5L(2), TAF7L(3), TAF9(1), TAF9B(2)	15853515	37	34	37	11	6	4	7	18	2	0	0.422	1.000	1.000
363	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), ABP1(4), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), AOC2(1), AOC3(1), AOX1(4), CAT(2), CYP1A1(1), CYP1A2(2), DDC(3), ECHS1(1), EHHADH(2), GCDH(1), HADH(1), HADHA(1), HSD17B4(1), INMT(1), LCMT1(1), LCMT2(2), MAOA(1), MAOB(1), METTL6(1), NFX1(3), OGDH(1), OGDHL(2), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(1), TPH1(3), WARS2(2)	26709962	59	50	59	15	6	5	20	23	5	0	0.142	1.000	1.000
364	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(2), CALM2(1), CAMK1(1), ELK1(1), FPR1(2), GNB1(2), MAP2K1(1), MAP2K3(2), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), NCF1(1), NCF2(1), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), PAK1(1), PIK3C2G(1), PLCB1(1), PPP3CB(1), PPP3CC(2), RELA(1), SYT1(1)	16959508	36	32	36	11	6	3	9	10	8	0	0.476	1.000	1.000
365	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACADM(1), ACADS(2), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), AOX1(4), AUH(1), BCKDHA(1), DBT(1), DLD(4), ECHS1(1), EHHADH(2), HADH(1), HADHA(1), HADHB(1), HIBADH(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), IVD(1), MCCC1(2), MCCC2(4), MCEE(1), MUT(2), OXCT1(1), PCCA(2), PCCB(2)	18939851	46	43	45	14	6	3	12	18	7	0	0.356	1.000	1.000
366	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(2), COL4A3(2), COL4A4(3), COL4A5(7), COL4A6(5), F11(1), F12(1), F2(2), F5(5), F8(4), FGA(2), FGB(1), FGG(2), KLKB1(1), PROC(2), PROS1(5), SERPING1(2)	19769733	47	43	47	16	8	1	16	14	8	0	0.476	1.000	1.000
367	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ABAT(1), ACADS(2), ACSM1(1), AKR1B10(3), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), BDH1(1), BDH2(1), DDHD1(1), ECHS1(1), EHHADH(2), GAD1(1), HADH(1), HADHA(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), ILVBL(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHB(1), PRDX6(1), RDH11(2)	17884292	34	33	33	11	6	3	8	11	6	0	0.433	1.000	1.000
368	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(1), CABIN1(4), CALM1(2), CALM2(1), CAMK1(1), IGF1(1), IGF1R(1), INSR(2), MAPK14(1), MAPK7(1), MEF2A(2), MEF2C(2), MEF2D(1), NFATC1(1), NFATC2(2), PIK3CA(14), PIK3R1(1), PPP3CB(1), PPP3CC(2), SYT1(1)	15337753	42	39	41	14	5	4	13	16	4	0	0.500	1.000	1.000
369	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(2), POLB(2), POLD1(3), POLD2(1), POLE(4), POLG(2), POLG2(4), POLH(1), POLI(2), POLK(2), POLL(1), POLM(1), POLQ(6), PRIM1(1), PRIM2(5), REV1(1), REV3L(5)	18076548	43	42	42	12	6	2	9	17	7	2	0.400	1.000	1.000
370	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(1), AKT2(2), AKT3(2), CD80(1), CD86(1), CXCL11(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR1(1), IFNAR2(1), IKBKB(1), IKBKE(1), IRAK1(3), IRAK4(1), JUN(1), MAP2K1(1), MAP2K3(2), MAP2K7(1), MAP3K7(2), MAPK1(1), MAPK10(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(1), MAPK9(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), RELA(1), RIPK1(2), SPP1(1), STAT1(2), TICAM1(3), TLR1(2), TLR2(1), TLR4(1), TLR5(1), TLR6(1), TLR7(1), TLR8(3)	39556002	84	73	83	18	6	6	24	38	10	0	0.0476	1.000	1.000
371	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(7), ACACB(4), ACADM(1), ACSS1(2), ACSS2(3), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1), LDHAL6B(1), LDHB(1), LDHC(2), MCEE(1), MLYCD(1), MUT(2), PCCA(2), PCCB(2), SUCLG1(2), SUCLG2(1)	17424222	43	41	43	14	4	5	17	9	8	0	0.384	1.000	1.000
372	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), ARSE(1), CYP11B2(2), CYP19A1(3), HSD17B1(1), HSD17B7(2), HSD17B8(1), HSD3B1(1), LCMT1(1), LCMT2(2), METTL6(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(1), SRD5A1(1), STS(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2A1(3), UGT2A3(4), UGT2B10(7), UGT2B11(2), UGT2B15(1), UGT2B7(2)	22214932	58	50	55	18	6	7	16	24	5	0	0.338	1.000	1.000
373	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(3), CD19(1), CD1A(1), CD1D(1), CD1E(1), CD22(1), CD33(1), CD34(2), CD38(1), CD3E(1), CD3G(1), CD4(1), CD44(2), CD55(2), CD7(1), CD8B(1), CR1(11), CR2(1), CSF1R(2), CSF2RA(2), CSF3R(1), DNTT(2), FCER2(1), FCGR1A(1), FLT3(2), HLA-DRA(1), IL1R2(1), IL2RA(2), IL3(1), IL3RA(1), IL4R(2), IL7R(1), IL9R(3), ITGA1(4), ITGA2(3), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(2), ITGAM(1), KITLG(2), MME(1), TFRC(2), TPO(2)	36006114	78	68	75	20	5	4	21	35	13	0	0.278	1.000	1.000
374	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(4), ATP4A(2), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP6V0A1(3), ATP6V0A4(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(2), COX15(1), COX17(1), COX4I2(1), COX7A2(1), NDUFA10(1), NDUFA13(3), NDUFA8(1), NDUFB11(1), NDUFB6(1), NDUFS1(3), NDUFS2(1), NDUFS3(2), NDUFS4(2), NDUFS5(1), NDUFS8(1), PPA2(1), SDHA(1), SDHB(1), SDHD(1), UQCRC2(1), UQCRFS1(3)	24558703	54	50	52	16	6	3	13	25	7	0	0.424	1.000	1.000
375	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(1), AKT2(2), AKT3(2), BCL10(1), BLNK(2), CARD11(3), CD19(1), CD22(1), CR2(1), GSK3B(1), IKBKB(1), INPP5D(1), JUN(1), KRAS(4), LILRB3(3), LYN(1), MALT1(2), NFAT5(3), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), NRAS(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PLCG2(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PTPN6(1), RAC3(1), SYK(1), VAV1(2), VAV2(3), VAV3(2)	32830158	82	70	81	22	5	6	29	31	11	0	0.163	1.000	1.000
376	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(1), AKT2(2), AKT3(2), BLNK(2), CD19(1), CD22(1), CR2(1), CSK(2), GSK3A(1), GSK3B(1), INPP5D(1), ITPR1(2), ITPR2(7), ITPR3(1), LYN(1), MAPK1(1), MAPK3(1), NFATC1(1), NFATC2(2), PDK1(1), PIK3CA(14), PIK3CD(1), PIK3R1(1), PLCG2(2), PPP1R13B(3), PPP3CB(1), PPP3CC(2), PTPRC(6), SHC1(2), SOS1(4), SOS2(1), SYK(1), VAV1(2)	32650819	72	60	71	19	10	6	22	25	9	0	0.169	1.000	1.000
377	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTG1(4), ACTN1(2), ACTN2(2), ACTN3(1), ACTN4(2), AKT1(1), AKT2(2), AKT3(2), ARHGAP5(3), BCAR1(2), BIRC2(2), BIRC3(2), BRAF(5), CAPN2(1), CCND2(1), CDC42(2), CHAD(2), COL11A1(8), COL11A2(1), COL1A1(1), COL1A2(7), COL2A1(5), COL3A1(1), COL4A1(2), COL4A4(3), COL4A6(5), COL5A1(1), COL5A2(3), COL5A3(8), COL6A2(5), COL6A3(11), COL6A6(9), CTNNB1(2), DOCK1(5), EGF(3), EGFR(4), ELK1(1), ERBB2(3), FIGF(2), FLNA(3), FLNB(2), FLNC(6), FLT1(3), FN1(6), FYN(1), GRLF1(3), GSK3B(1), HGF(1), IGF1(1), IGF1R(1), ITGA1(4), ITGA10(2), ITGA11(3), ITGA2(3), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(2), ITGB1(2), ITGB5(2), ITGB6(3), ITGB8(1), JUN(1), KDR(5), LAMA1(8), LAMA2(8), LAMA3(2), LAMA4(5), LAMA5(4), LAMB1(2), LAMB2(2), LAMB4(6), LAMC1(3), LAMC2(5), LAMC3(5), MAP2K1(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(1), MAPK9(1), MET(5), MYL2(1), MYL7(1), MYL9(1), MYLK(3), MYLK2(2), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PARVG(1), PDGFA(1), PDGFD(1), PDGFRA(6), PDGFRB(1), PGF(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PIP5K1C(1), PPP1CB(1), PPP1R12A(4), PRKCG(1), PTEN(16), PTK2(1), PXN(2), RAC3(1), RAP1B(2), RAPGEF1(1), RELN(5), ROCK1(3), ROCK2(3), SHC1(2), SHC2(1), SOS1(4), SOS2(1), SPP1(1), SRC(1), THBS1(5), THBS2(2), THBS3(3), THBS4(1), TLN1(6), TLN2(7), TNC(3), TNN(1), TNR(5), TNXB(2), VAV1(2), VAV2(3), VAV3(2), VCL(1), VTN(1), VWF(6), ZYX(1)	164122610	409	202	407	144	40	28	129	151	61	0	0.513	1.000	1.000
378	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(1), ADCY2(1), ADCY3(1), ADCY8(5), ADCY9(3), ADORA2A(2), ADRA1A(1), ADRB2(1), AGTR1(1), ATP2A1(2), ATP2A2(2), ATP2B1(2), ATP2B2(1), AVPR1A(2), BDKRB1(1), BDKRB2(1), CACNA1A(1), CACNA1B(3), CACNA1C(8), CACNA1D(6), CACNA1E(3), CACNA1F(4), CACNA1G(4), CACNA1H(2), CACNA1I(2), CACNA1S(8), CALM1(2), CALM2(1), CAMK2D(1), CAMK2G(2), CCKAR(1), CCKBR(1), CD38(1), CHRM2(3), CHRM3(2), CHRM5(1), CYSLTR1(1), DRD1(1), EDNRB(1), EGFR(4), ERBB2(3), ERBB3(5), ERBB4(7), GNA11(1), GNA14(1), GNAS(3), GRIN1(2), GRIN2A(3), GRM1(4), GRM5(3), HTR2A(2), HTR2C(1), HTR5A(1), HTR7(1), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(1), LHCGR(1), MYLK(3), MYLK2(2), NOS1(7), NOS3(1), NTSR1(1), P2RX1(2), P2RX2(2), P2RX3(1), PDE1B(2), PDE1C(2), PDGFRA(6), PDGFRB(1), PHKA1(2), PHKA2(1), PHKB(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCD4(2), PLCE1(3), PLCG2(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKACA(1), PRKACB(1), PRKACG(2), PRKCG(1), PRKX(1), PTGFR(1), PTK2B(2), RYR1(12), RYR2(12), RYR3(14), SLC25A4(1), SLC25A6(1), SLC8A1(3), SLC8A2(1), SLC8A3(3), SPHK2(1), TACR1(1), TACR3(3), TBXA2R(1), TRHR(2), TRPC1(2), VDAC2(1), VDAC3(1)	119265408	261	176	261	105	44	17	63	114	23	0	0.922	1.000	1.000
379	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(3), ACVR1C(2), AKT1(1), AKT2(2), AKT3(2), ATF2(1), BRAF(5), CACNA1A(1), CACNA1B(3), CACNA1C(8), CACNA1D(6), CACNA1E(3), CACNA1F(4), CACNA1G(4), CACNA1H(2), CACNA1I(2), CACNA1S(8), CACNA2D1(2), CACNA2D4(2), CACNB2(1), CACNG3(2), CACNG6(1), CACNG7(1), CACNG8(1), CDC42(2), DAXX(4), DUSP10(1), DUSP14(1), DUSP5(1), DUSP7(1), DUSP9(1), ECSIT(1), EGF(3), EGFR(4), ELK1(1), ELK4(2), FAS(3), FGF13(1), FGF14(1), FGF20(1), FGF23(1), FGF3(1), FGF5(1), FGF6(1), FGF9(1), FGFR1(4), FGFR2(4), FGFR3(1), FGFR4(2), FLNA(3), FLNB(2), FLNC(6), IKBKB(1), IL1R2(1), JUN(1), KRAS(4), MAP2K1(1), MAP2K3(2), MAP2K7(1), MAP3K1(3), MAP3K10(2), MAP3K12(1), MAP3K13(1), MAP3K14(1), MAP3K2(2), MAP3K4(6), MAP3K5(4), MAP3K6(2), MAP3K7(2), MAP4K3(2), MAP4K4(2), MAPK1(1), MAPK10(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MAPT(2), MAX(3), MEF2C(2), MKNK1(1), MKNK2(2), MRAS(1), NF1(11), NFATC2(2), NFATC4(2), NR4A1(1), NRAS(1), NTRK1(2), NTRK2(1), PAK1(1), PAK2(2), PDGFA(1), PDGFRA(6), PDGFRB(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(1), PPM1B(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PPP5C(1), PRKACA(1), PRKACB(1), PRKACG(2), PRKCG(1), PRKX(1), PTPN5(1), PTPN7(1), PTPRR(2), RAC3(1), RAP1B(2), RAPGEF2(8), RASA1(2), RASA2(1), RASGRF1(3), RASGRF2(2), RASGRP2(2), RASGRP4(2), RPS6KA1(2), RPS6KA2(1), RPS6KA6(3), SOS1(4), SOS2(1), STK3(1), TAOK3(1), TGFB2(1), TGFBR2(1), TNFRSF1A(2), TP53(13), ZAK(2)	126754339	292	174	292	110	34	18	82	117	41	0	0.824	1.000	1.000
380	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(2), ACTN1(2), ACTN2(2), ACTN3(1), ACTN4(2), APC(6), APC2(4), ARHGEF1(1), ARHGEF12(2), ARHGEF6(1), ARHGEF7(2), ARPC2(1), ARPC3(1), BCAR1(2), BDKRB1(1), BDKRB2(1), BRAF(5), CDC42(2), CHRM2(3), CHRM3(2), CHRM5(1), CSK(2), CYFIP1(1), CYFIP2(2), DIAPH2(4), DIAPH3(1), DOCK1(5), EGF(3), EGFR(4), F2(2), FGD1(1), FGF13(1), FGF14(1), FGF20(1), FGF23(1), FGF3(1), FGF5(1), FGF6(1), FGF9(1), FGFR1(4), FGFR2(4), FGFR3(1), FGFR4(2), FN1(6), GNA13(2), GRLF1(3), GSN(1), IQGAP1(2), IQGAP2(2), IQGAP3(1), ITGA1(4), ITGA10(2), ITGA11(3), ITGA2(3), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(2), ITGAD(2), ITGAE(3), ITGAL(3), ITGAM(1), ITGAX(2), ITGB1(2), ITGB2(1), ITGB5(2), ITGB6(3), ITGB8(1), KRAS(4), LIMK1(2), LIMK2(1), MAP2K1(1), MAPK1(1), MAPK3(1), MRAS(1), MSN(4), MYH10(1), MYH14(2), MYH9(2), MYL2(1), MYL7(1), MYL9(1), MYLK(3), MYLK2(2), NCKAP1(2), NCKAP1L(1), NRAS(1), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PDGFA(1), PDGFRA(6), PDGFRB(1), PFN4(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PIP4K2A(1), PIP4K2C(1), PIP5K1C(1), PPP1CB(1), PPP1R12A(4), PPP1R12B(1), PTK2(1), PXN(2), RAC3(1), RDX(1), ROCK1(3), ROCK2(3), SCIN(1), SLC9A1(2), SOS1(4), SOS2(1), SSH1(3), SSH2(3), SSH3(1), TIAM1(2), TIAM2(1), VAV1(2), VAV2(3), VAV3(2), VCL(1), WASF1(2), WASF2(1), WASL(5)	122465623	278	169	277	113	25	25	87	110	31	0	0.920	1.000	1.000
381	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTG1(4), CHAD(2), COL11A1(8), COL11A2(1), COL17A1(1), COL1A1(1), COL1A2(7), COL2A1(5), COL3A1(1), COL4A1(2), COL4A4(3), COL4A6(5), COL5A1(1), COL5A2(3), COL5A3(8), COL6A2(5), COL6A3(11), COL6A6(9), DSC1(1), DSC2(1), DSC3(1), DSG1(5), DSG2(1), DSG3(1), DSG4(2), FN1(6), GJA10(1), GJA3(1), GJA5(1), GJA8(1), GJA9(2), GJB3(1), GJB6(2), GJC1(1), GJC2(1), GJD2(2), ITGA6(2), KRT1(5), KRT12(1), KRT13(2), KRT15(1), KRT16(1), KRT2(2), KRT23(1), KRT24(1), KRT27(1), KRT28(1), KRT3(1), KRT31(2), KRT36(2), KRT39(2), KRT4(3), KRT5(1), KRT6B(2), KRT6C(1), KRT7(1), KRT71(1), KRT74(1), KRT75(2), KRT78(1), KRT79(2), KRT82(2), KRT84(1), KRT85(2), KRT9(1), LAMA1(8), LAMA2(8), LAMA3(2), LAMA4(5), LAMA5(4), LAMB1(2), LAMB2(2), LAMB4(6), LAMC1(3), LAMC2(5), LAMC3(5), LMNA(1), NES(2), PRPH(1), RELN(5), SPP1(1), THBS1(5), THBS2(2), THBS3(3), THBS4(1), TNC(3), TNN(1), TNR(5), TNXB(2), VIM(1), VTN(1), VWF(6)	109843946	244	160	240	86	35	10	66	95	38	0	0.553	1.000	1.000
382	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(4), CD44(2), CHAD(2), COL11A1(8), COL11A2(1), COL1A1(1), COL1A2(7), COL2A1(5), COL3A1(1), COL4A1(2), COL4A4(3), COL4A6(5), COL5A1(1), COL5A2(3), COL5A3(8), COL6A2(5), COL6A3(11), COL6A6(9), FN1(6), FNDC1(3), FNDC3A(2), HMMR(2), HSPG2(9), ITGA1(4), ITGA10(2), ITGA11(3), ITGA2(3), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(2), ITGB1(2), ITGB5(2), ITGB6(3), ITGB8(1), LAMA1(8), LAMA2(8), LAMA3(2), LAMA4(5), LAMA5(4), LAMB1(2), LAMB2(2), LAMB4(6), LAMC1(3), LAMC2(5), LAMC3(5), RELN(5), SPP1(1), SV2C(3), THBS1(5), THBS2(2), THBS3(3), THBS4(1), TNC(3), TNN(1), TNR(5), TNXB(2), VTN(1), VWF(6)	99344543	220	153	219	78	28	12	64	83	33	0	0.522	1.000	1.000
383	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADORA2A(2), ADORA3(1), ADRA1A(1), ADRB2(1), AGTR1(1), AGTR2(1), AVPR1A(2), AVPR2(1), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(1), CCKBR(1), CHRM2(3), CHRM3(2), CHRM5(1), CNR1(1), CNR2(1), CRHR2(1), CYSLTR1(1), DRD1(1), DRD2(1), DRD3(1), DRD5(3), EDNRB(1), F2(2), F2RL2(1), FPR1(2), GABBR1(1), GABRA1(1), GABRA3(1), GABRA4(3), GABRA5(2), GABRA6(1), GABRB1(1), GABRB3(1), GABRD(1), GABRE(3), GABRG1(1), GABRG2(4), GABRQ(4), GABRR1(2), GABRR2(1), GALR1(1), GH1(1), GH2(1), GHR(1), GHRHR(1), GIPR(1), GLP1R(1), GLRA2(2), GPR35(1), GPR50(1), GPR63(1), GPR83(2), GRIA1(4), GRIA2(1), GRIA3(1), GRIA4(2), GRID1(3), GRID2(5), GRIK1(2), GRIK2(4), GRIK3(2), GRIK5(3), GRIN1(2), GRIN2A(3), GRIN2B(11), GRIN3A(1), GRIN3B(2), GRM1(4), GRM2(1), GRM3(2), GRM4(2), GRM5(3), GRM6(1), GRM7(1), GZMA(1), HCRTR2(1), HRH4(1), HTR1A(2), HTR1E(3), HTR2A(2), HTR2C(1), HTR5A(1), HTR7(1), LEPR(1), LHCGR(1), LTB4R(1), MAS1(1), MC2R(2), MC3R(1), MC4R(1), MCHR2(2), MTNR1B(1), NMUR2(2), NPBWR1(1), NPBWR2(1), NPFFR2(3), NPY2R(1), NTSR1(1), OPRD1(3), OPRL1(2), OPRM1(3), P2RX1(2), P2RX2(2), P2RX3(1), P2RY10(1), P2RY13(1), P2RY14(1), P2RY2(1), P2RY6(1), P2RY8(1), PARD3(3), PRLR(2), PTGER2(1), PTGFR(1), PTGIR(1), RXFP1(1), SCTR(1), SSTR1(1), SSTR3(1), SSTR4(1), TAAR1(1), TAAR2(1), TAAR9(1), TACR1(1), TACR3(3), TBXA2R(1), THRA(3), TRHR(2), VIPR1(1), VIPR2(1)	97456328	219	152	219	69	35	20	54	97	13	0	0.305	1.000	1.000
384	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTG1(4), ACTN1(2), ACTN2(2), ACTN3(1), ACTN4(2), AKT1(1), AKT2(2), AKT3(2), AMOTL1(1), ASH1L(8), CDC42(2), CDK4(1), CGN(1), CLDN10(3), CLDN16(1), CLDN18(2), CLDN22(1), CLDN4(1), CLDN7(1), CSDA(3), CTNNA1(4), CTNNA2(3), CTNNA3(3), CTNNB1(2), EPB41L1(1), EPB41L2(1), EPB41L3(4), EXOC4(2), F11R(1), GNAI1(2), GNAI2(1), HCLS1(1), INADL(5), JAM2(1), KRAS(4), LLGL1(2), LLGL2(1), MAGI1(1), MAGI2(5), MAGI3(4), MLLT4(7), MPDZ(3), MPP5(1), MRAS(1), MYH1(9), MYH10(1), MYH11(3), MYH13(5), MYH14(2), MYH15(2), MYH2(6), MYH3(5), MYH4(7), MYH6(2), MYH7(3), MYH7B(1), MYH8(4), MYH9(2), MYL2(1), MYL7(1), MYL9(1), NRAS(1), PARD3(3), PARD6B(3), PPM1J(1), PPP2CA(1), PPP2CB(1), PPP2R1B(1), PPP2R2A(1), PPP2R2B(3), PPP2R3A(1), PPP2R4(1), PRKCD(1), PRKCE(4), PRKCG(1), PRKCH(3), PRKCI(3), PRKCQ(1), PTEN(16), SPTAN1(3), SRC(1), TJAP1(1), TJP1(4), TJP2(2), TJP3(1), YES1(1), ZAK(2)	85606176	217	143	215	84	28	11	57	82	39	0	0.902	1.000	1.000
385	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(1), ADCY2(1), ADCY3(1), ADCY5(3), ADCY6(2), ADCY8(5), ADCY9(3), ADRA1A(1), ADRB2(1), ANXA6(1), ATP1A4(3), ATP2A2(2), ATP2B1(2), ATP2B2(1), CACNA1A(1), CACNA1B(3), CACNA1C(8), CACNA1D(6), CACNA1E(3), CACNA1S(8), CALM1(2), CALM2(1), CALR(1), CAMK1(1), CAMK2D(1), CAMK2G(2), CASQ1(1), CASQ2(1), CHRM2(3), CHRM3(2), CHRM5(1), GJA5(1), GJB3(1), GJB6(2), GNA11(1), GNAI2(1), GNAO1(1), GNB1(2), GNB4(1), GNB5(1), GNG3(1), GRK4(1), GRK6(3), ITPR1(2), ITPR2(7), ITPR3(1), KCNB1(1), KCNJ3(3), MIB1(2), MYCBP(1), NME7(1), PLCB3(1), PRKACA(1), PRKACB(1), PRKAR1A(1), PRKAR2B(2), PRKCD(1), PRKCE(4), PRKCG(1), PRKCH(3), PRKCQ(1), PRKD1(4), RGS11(1), RGS18(1), RGS2(1), RGS3(4), RGS4(1), RGS6(2), RGS7(1), RGS9(2), RYR1(12), RYR2(12), RYR3(14), SLC8A1(3), SLC8A3(3), USP5(1)	83356100	184	135	182	62	32	13	42	77	20	0	0.497	1.000	1.000
386	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(3), ABLIM1(1), ABLIM3(3), ARHGEF12(2), CDC42(2), CXCR4(1), DCC(4), EFNB2(1), EPHA1(1), EPHA4(1), EPHA5(4), EPHA6(2), EPHA7(5), EPHA8(4), EPHB1(1), EPHB2(1), EPHB3(1), EPHB4(3), EPHB6(4), FES(2), FYN(1), GNAI1(2), GNAI2(1), GSK3B(1), ITGB1(2), KRAS(4), L1CAM(3), LIMK1(2), LIMK2(1), MAPK1(1), MAPK3(1), MET(5), NFAT5(3), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), NGEF(1), NRAS(1), NRP1(3), NTN4(2), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PLXNA1(2), PLXNA2(4), PLXNA3(1), PLXNB1(3), PLXNB2(2), PLXNC1(4), PPP3CB(1), PPP3CC(2), PPP3R1(1), PTK2(1), RAC3(1), RASA1(2), RGS3(4), RND1(2), ROBO1(4), ROBO2(2), ROBO3(1), ROCK1(3), ROCK2(3), SEMA3A(1), SEMA3C(1), SEMA3D(2), SEMA3E(3), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4D(1), SEMA4F(1), SEMA4G(2), SEMA5A(1), SEMA6D(3), SLIT1(2), SLIT2(5), SLIT3(5), SRGAP1(3), SRGAP2(1), SRGAP3(2), UNC5A(2), UNC5B(1), UNC5C(1), UNC5D(2)	87091410	182	133	182	78	19	12	53	81	17	0	0.960	1.000	1.000
387	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(8), ASH2L(2), C17orf79(1), CTCFL(2), DOT1L(3), EED(1), EHMT1(1), EHMT2(2), EZH2(4), FBXO11(1), HCFC1(3), HSF4(2), JMJD4(1), JMJD6(3), KDM6A(2), MEN1(1), MLL(5), MLL2(10), MLL3(20), MLL4(4), MLL5(8), NSD1(5), OGT(3), PPP1CB(1), PRDM9(3), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(1), RBBP5(3), SETD1A(1), SETD2(32), SETDB1(3), SETMAR(1), SUV39H2(3), SUV420H1(2), SUZ12(3), WHSC1(3), WHSC1L1(4)	52455702	158	123	156	47	12	16	36	48	45	1	0.283	1.000	1.000
388	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	251	ACVR1B(3), ACVR2A(3), ACVR2B(1), AMHR2(1), BMP7(1), BMPR1B(1), BMPR2(4), CCL2(1), CCL27(1), CCL28(1), CCR4(1), CCR6(1), CD27(1), CNTF(1), CSF1R(2), CSF2RA(2), CSF2RB(1), CSF3R(1), CX3CR1(1), CXCL11(1), CXCR4(1), CXCR6(2), EDA(2), EGF(3), EGFR(4), FAS(3), FLT1(3), FLT3(2), FLT4(4), GDF5(1), GH1(1), GH2(1), GHR(1), HGF(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR1(1), IFNAR2(1), IFNGR1(1), IFNW1(1), IL12RB2(1), IL15(1), IL17RB(1), IL18RAP(3), IL19(2), IL1R2(1), IL1RAP(2), IL20RA(1), IL21(1), IL21R(2), IL23A(1), IL23R(1), IL25(1), IL26(1), IL28A(1), IL28B(1), IL2RA(2), IL2RB(1), IL3(1), IL3RA(1), IL4R(2), IL6ST(3), IL7R(1), IL9R(3), INHBA(1), KDR(5), KITLG(2), LEPR(1), LIFR(2), LTA(1), LTBR(2), MET(5), MPL(1), NGFR(1), OSMR(1), PDGFRA(6), PDGFRB(1), PF4(1), PLEKHO2(1), PRLR(2), RELT(1), TGFB2(1), TGFBR2(1), TNFRSF10A(1), TNFRSF11B(1), TNFRSF14(1), TNFRSF1A(2), TNFRSF4(1), TNFRSF9(1), TNFSF11(1), TNFSF14(2), TPO(2), XCL1(1), XCR1(1)	78281016	154	118	154	50	11	6	49	79	9	0	0.492	1.000	1.000
389	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(6), APC2(4), AXIN1(1), AXIN2(1), CACYBP(1), CAMK2D(1), CAMK2G(2), CCND2(1), CHD8(5), CREBBP(4), CSNK1A1(1), CSNK1E(2), CTBP1(1), CTNNB1(2), CUL1(3), DAAM1(3), DKK1(1), DVL1(1), EP300(6), FBXW11(1), FZD1(2), FZD10(2), FZD2(1), FZD3(1), FZD4(1), FZD5(1), FZD6(1), GSK3B(1), JUN(1), LEF1(1), LRP5(2), LRP6(3), MAP3K7(2), MAPK10(2), MAPK8(1), MAPK9(1), NFAT5(3), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), NKD1(2), NKD2(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PORCN(1), PPP2CA(1), PPP2CB(1), PPP2R1B(1), PPP2R2A(1), PPP2R2B(3), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRICKLE1(2), PRKACA(1), PRKACB(1), PRKACG(2), PRKCG(1), PRKX(1), RAC3(1), ROCK1(3), ROCK2(3), RUVBL1(1), SFRP1(2), SFRP4(2), SMAD2(3), SMAD4(3), TBL1X(1), TBL1XR1(3), TBL1Y(1), TCF7(2), TCF7L2(1), TP53(13), VANGL1(2), WNT16(1), WNT2(2), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1), WNT9A(1)	71394046	159	117	157	77	12	12	51	63	21	0	0.993	1.000	1.000
390	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(3), ANAPC1(4), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(2), ANAPC7(1), ATM(14), ATR(5), BUB1(2), BUB1B(1), BUB3(1), CCNA1(1), CCNB2(5), CCNB3(4), CCND2(1), CCNE1(1), CCNH(1), CDC14A(4), CDC16(2), CDC20(1), CDC23(2), CDC25A(1), CDC25C(2), CDC27(5), CDC6(1), CDC7(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(3), CDKN2C(1), CHEK1(1), CHEK2(7), CREBBP(4), CUL1(3), EP300(6), ESPL1(6), FZR1(1), GSK3B(1), HDAC1(1), MAD2L1(1), MCM2(3), MCM5(1), MCM6(1), MCM7(6), ORC1L(2), ORC3L(1), ORC4L(1), ORC5L(1), ORC6L(1), PCNA(2), PRKDC(5), RB1(2), RBL2(3), SKP2(1), SMAD2(3), SMAD4(3), SMC1A(1), SMC1B(3), TGFB2(1), TP53(13), YWHAE(2)	60407937	163	116	160	75	10	17	53	58	25	0	0.969	1.000	1.000
391	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(1), AKT2(2), AKT3(2), CBL(2), CBLB(3), CBLC(1), CCND2(1), CNTF(1), CREBBP(4), CSF2RA(2), CSF2RB(1), CSF3R(1), EP300(6), GH1(1), GH2(1), GHR(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR1(1), IFNAR2(1), IFNGR1(1), IFNW1(1), IL12RB2(1), IL15(1), IL19(2), IL20RA(1), IL21(1), IL21R(2), IL23A(1), IL23R(1), IL26(1), IL28A(1), IL28B(1), IL2RA(2), IL2RB(1), IL3(1), IL3RA(1), IL4R(2), IL6ST(3), IL7R(1), IL9R(3), IRF9(2), JAK1(4), JAK2(5), JAK3(2), LEPR(1), LIFR(2), MPL(1), OSMR(1), PIAS1(2), PIAS3(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PRLR(2), PTPN11(1), PTPN6(1), SOCS4(1), SOS1(4), SOS2(1), SPRED1(4), SPRED2(1), SPRY2(2), SPRY4(1), STAM(2), STAT1(2), STAT2(3), STAT3(1), STAT4(2), STAT5A(2), STAT6(1), TPO(2), TYK2(3)	64029997	151	116	150	49	11	10	53	65	12	0	0.422	1.000	1.000
392	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(7), ACACB(4), AKT1(1), AKT2(2), AKT3(2), BRAF(5), CALM1(2), CALM2(1), CBL(2), CBLB(3), CBLC(1), ELK1(1), EXOC7(1), FASN(3), FOXO1(1), G6PC(1), GSK3B(1), GYS1(2), GYS2(1), IKBKB(1), INPP5D(1), INSR(2), IRS1(3), IRS2(1), KRAS(4), LIPE(4), MAP2K1(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(1), MAPK9(1), MKNK1(1), MKNK2(2), NRAS(1), PCK1(2), PCK2(2), PDE3A(3), PDE3B(3), PFKL(2), PFKM(1), PHKA1(2), PHKA2(1), PHKB(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PPARGC1A(1), PPP1CB(1), PPP1R3A(4), PPP1R3D(1), PRKAA1(1), PRKACA(1), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAG2(1), PRKAR1A(1), PRKAR2B(2), PRKCI(3), PRKX(1), PTPN1(1), PTPRF(2), PYGB(1), PYGL(1), PYGM(2), RAPGEF1(1), RHEB(2), RHOQ(1), RPS6KB1(2), RPS6KB2(1), SH2B2(1), SHC1(2), SHC2(1), SOCS4(1), SORBS1(1), SOS1(4), SOS2(1), SREBF1(1), TSC1(4), TSC2(2)	70765460	164	115	163	44	17	13	48	65	21	0	0.0889	1.000	1.000
393	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(1), ADCY2(1), ADCY3(1), ADCY5(3), ADCY6(2), ADCY8(5), ADCY9(3), ATF1(1), ATF2(1), ATP2A2(2), CALM1(2), CALM2(1), CAMK2D(1), CAMK2G(2), CORIN(1), DGKZ(2), GABPA(1), GBA2(2), GNB1(2), GNB4(1), GNB5(1), GNG3(1), GRK4(1), GRK6(3), GUCY1A3(1), IGFBP4(1), IGFBP6(1), ITPR1(2), ITPR2(7), ITPR3(1), JUN(1), MIB1(2), MYL2(1), MYLK2(2), NOS1(7), NOS3(1), PDE4B(1), PDE4D(1), PLCB3(1), PLCD1(1), PLCG2(2), PRKACA(1), PRKACB(1), PRKAR1A(1), PRKAR2B(2), PRKCD(1), PRKCE(4), PRKCH(3), PRKCQ(1), PRKD1(4), RAMP1(1), RGS11(1), RGS18(1), RGS2(1), RGS3(4), RGS4(1), RGS6(2), RGS7(1), RGS9(2), RYR1(12), RYR2(12), RYR3(14), SLC8A1(3), SP1(1), TNXB(2), USP5(1)	76811484	151	115	149	61	23	6	42	64	16	0	0.898	1.000	1.000
394	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTN2(2), ACTN3(1), ACTN4(2), DMD(9), FAM48A(1), MYBPC1(2), MYBPC2(2), MYBPC3(1), MYH3(5), MYH6(2), MYH7(3), MYH8(4), MYL2(1), MYL9(1), MYOM1(5), NEB(12), TMOD1(2), TNNI1(1), TNNI3(1), TNNT1(3), TNNT3(1), TPM2(1), TTN(98), VIM(1)	60975040	161	113	161	48	19	11	50	62	19	0	0.244	1.000	1.000
395	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(3), ACTN1(2), ACTR2(2), ACTR3(1), AKT1(1), AKT2(2), AKT3(2), ARHGEF6(1), ARHGEF7(2), BCAR1(2), BRAF(5), CDC42(2), CDKN2A(3), CSE1L(1), DOCK1(5), EPHB2(1), FYN(1), GRB7(2), GRLF1(3), ITGA1(4), ITGA10(2), ITGA11(3), ITGA2(3), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(2), MAP2K7(1), MAP3K11(1), MAPK1(1), MAPK10(2), MAPK8(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MRAS(1), MYLK(3), MYLK2(2), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PIK3CA(14), PIK3CB(2), PLCG2(2), PTEN(16), PTK2(1), ROCK1(3), ROCK2(3), SHC1(2), SOS1(4), SOS2(1), SRC(1), TLN1(6), TLN2(7), ZYX(1)	54051301	152	111	151	48	7	15	55	55	20	0	0.268	1.000	1.000
396	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(1), CADM1(2), CADM3(2), CD22(1), CD274(2), CD28(2), CD34(2), CD4(1), CD6(2), CD80(1), CD86(1), CD8B(1), CD99(1), CDH1(3), CDH15(1), CDH2(3), CDH3(2), CDH4(2), CDH5(2), CLDN10(3), CLDN16(1), CLDN18(2), CLDN22(1), CLDN4(1), CLDN7(1), CNTN1(3), CNTN2(1), CNTNAP1(3), CNTNAP2(3), ESAM(1), F11R(1), GLG1(6), HLA-B(1), HLA-DMB(1), HLA-DPA1(1), HLA-DRA(1), HLA-E(2), HLA-F(1), ICAM2(1), ITGA4(2), ITGA6(2), ITGA8(2), ITGA9(2), ITGAL(3), ITGAM(1), ITGB1(2), ITGB2(1), ITGB8(1), JAM2(1), L1CAM(3), MADCAM1(4), MPZL1(1), NCAM1(1), NCAM2(1), NEGR1(2), NEO1(2), NFASC(3), NLGN1(1), NRCAM(2), NRXN1(9), NRXN2(2), NRXN3(2), PTPRC(6), PTPRF(2), PTPRM(4), PVRL2(1), PVRL3(2), SELE(2), SELP(2), SELPLG(1), SIGLEC1(2), VCAM1(2), VCAN(3)	65167216	144	110	142	63	12	9	43	63	17	0	0.963	1.000	1.000
397	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(2), ACTN2(2), ACTN3(1), ACTN4(2), ARHGAP5(3), BCAR1(2), CD99(1), CDC42(2), CDH5(2), CLDN10(3), CLDN16(1), CLDN18(2), CLDN22(1), CLDN4(1), CLDN7(1), CTNNA1(4), CTNNA2(3), CTNNA3(3), CTNNB1(2), CTNND1(4), CXCR4(1), ESAM(1), F11R(1), GNAI1(2), GNAI2(1), GRLF1(3), ITGA4(2), ITGAL(3), ITGAM(1), ITGB1(2), ITGB2(1), JAM2(1), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(7), MMP2(1), MSN(4), MYL2(1), MYL7(1), MYL9(1), NCF1(1), NCF2(1), NOX1(2), NOX3(2), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PLCG2(2), PRKCG(1), PTK2(1), PTK2B(2), PTPN11(1), PXN(2), RAP1B(2), RAPGEF3(1), RAPGEF4(1), RASSF5(1), RHOH(1), ROCK1(3), ROCK2(3), TXK(1), VAV1(2), VAV2(3), VAV3(2), VCAM1(2), VCL(1)	54872804	143	104	142	54	11	10	43	52	27	0	0.726	1.000	1.000
398	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(1), ADCY2(1), ADCY3(1), ADCY5(3), ADCY6(2), ADCY8(5), ADCY9(3), ADSL(1), AK2(1), AK3L1(1), ALLC(3), AMPD1(1), AMPD2(1), ATIC(1), ENPP3(2), ENTPD2(1), ENTPD4(1), ENTPD6(1), GDA(2), GMPR(2), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), HPRT1(1), IMPDH1(2), IMPDH2(1), NME7(1), NPR1(1), NPR2(1), NT5C1B(1), NT5C3(1), NT5M(1), PAICS(2), PAPSS1(2), PAPSS2(1), PDE10A(1), PDE11A(3), PDE1C(2), PDE2A(3), PDE3B(3), PDE4A(3), PDE4B(1), PDE4C(3), PDE4D(1), PDE5A(2), PDE8A(3), PFAS(1), POLA1(2), POLD1(3), POLD2(1), POLE(4), POLR1A(1), POLR1B(2), POLR2A(5), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(2), POLR3B(4), POLR3G(2), POLR3H(1), PRIM1(1), PRIM2(5), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RRM1(1), RRM2(1), XDH(1)	72252209	131	103	127	45	16	6	47	40	20	2	0.497	1.000	1.000
399	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTG1(4), ACTN1(2), ACTN2(2), ACTN3(1), ACTN4(2), ACVR1B(3), ACVR1C(2), CDC42(2), CDH1(3), CREBBP(4), CTNNA1(4), CTNNA2(3), CTNNA3(3), CTNNB1(2), CTNND1(4), EGFR(4), EP300(6), ERBB2(3), FER(1), FGFR1(4), FYN(1), IGF1R(1), INSR(2), IQGAP1(2), LEF1(1), LMO7(4), MAP3K7(2), MAPK1(1), MAPK3(1), MET(5), MLLT4(7), PARD3(3), PTPN1(1), PTPN6(1), PTPRB(4), PTPRF(2), PTPRJ(4), PTPRM(4), PVRL2(1), PVRL3(2), RAC3(1), SMAD2(3), SMAD4(3), SNAI1(1), SNAI2(1), SORBS1(1), SRC(1), TCF7(2), TCF7L2(1), TGFBR2(1), TJP1(4), VCL(1), WASF1(2), WASF2(1), WASF3(1), WASL(5), YES1(1)	52730305	138	103	137	50	8	14	43	60	13	0	0.734	1.000	1.000
400	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(1), ADCY2(1), ADCY3(1), ADCY5(3), ADCY6(2), ADCY8(5), ADCY9(3), DRD1(1), DRD2(1), EGF(3), EGFR(4), GJD2(2), GNA11(1), GNAI1(2), GNAI2(1), GNAS(3), GRM1(4), GRM5(3), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), HTR2A(2), HTR2C(1), ITPR1(2), ITPR2(7), ITPR3(1), KRAS(4), MAP2K1(1), MAP3K2(2), MAPK1(1), MAPK3(1), MAPK7(1), NPR1(1), NPR2(1), NRAS(1), PDGFA(1), PDGFD(1), PDGFRA(6), PDGFRB(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PRKACA(1), PRKACB(1), PRKACG(2), PRKCG(1), PRKG1(2), PRKG2(3), PRKX(1), SOS1(4), SOS2(1), SRC(1), TJP1(4), TUBA1A(1), TUBA3C(1), TUBA3D(2), TUBA4A(2), TUBAL3(1), TUBB(1), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), TUBB6(1)	58275598	129	102	129	51	17	7	36	56	13	0	0.880	1.000	1.000
401	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(2), CALM2(1), CDS2(1), DGKB(1), DGKG(2), DGKH(4), DGKI(1), DGKQ(1), DGKZ(2), IMPA2(1), INPP4A(1), INPP4B(3), INPP5A(1), INPP5B(3), INPP5D(1), INPPL1(1), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(1), OCRL(2), PI4KA(9), PI4KB(2), PIK3C2A(2), PIK3C2G(1), PIK3C3(4), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PIP4K2A(1), PIP4K2C(1), PIP5K1C(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCD4(2), PLCE1(3), PLCG2(2), PRKCG(1), PTEN(16), SYNJ1(4), SYNJ2(3)	55281202	126	101	125	52	15	7	38	41	25	0	0.858	1.000	1.000
402	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), AKT3(2), BCAR1(2), CAPN1(1), CAPN10(1), CAPN11(1), CAPN2(1), CAPN3(3), CAPN6(1), CAPN7(1), CAPN9(2), CDC42(2), CSK(2), DOCK1(5), FYN(1), GIT2(1), ITGA10(2), ITGA11(3), ITGA2(3), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(2), ITGAD(2), ITGAE(3), ITGAL(3), ITGAM(1), ITGAX(2), ITGB1(2), ITGB2(1), ITGB5(2), ITGB6(3), ITGB8(1), MAP2K1(1), MAP2K3(2), MAPK10(2), MAPK12(1), MAPK4(1), MAPK6(3), MAPK7(1), MYLK2(2), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PIK3R2(1), PTK2(1), PXN(2), RAC3(1), RAP1B(2), RAPGEF1(1), ROCK1(3), ROCK2(3), SDCCAG8(1), SHC1(2), SORBS1(1), SOS1(4), SRC(1), TLN1(6), TNS1(2), VAV2(3), VAV3(2), VCL(1), ZYX(1)	59320539	124	99	124	42	12	10	39	51	12	0	0.453	1.000	1.000
403	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(3), ATM(14), BUB1(2), BUB1B(1), BUB3(1), CCNA1(1), CCNB2(5), CCNB3(4), CCND2(1), CCNE1(1), CCNH(1), CDAN1(3), CDC14A(4), CDC20(1), CDC25A(1), CDC25C(2), CDC6(1), CDC7(1), CDH1(3), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(3), CHEK1(1), CHEK2(7), DTX4(1), E2F4(1), E2F5(1), E2F6(1), EP300(6), ESPL1(6), GSK3B(1), HDAC1(1), HDAC4(1), HDAC6(2), MAD2L1(1), MCM2(3), MCM5(1), MCM6(1), MCM7(6), MPEG1(1), MPL(1), ORC1L(2), ORC3L(1), ORC4L(1), ORC5L(1), ORC6L(1), PCNA(2), PRKDC(5), RB1(2), SKP2(1), SMAD4(3), TBC1D8(4), TP53(13)	48873530	135	98	132	60	10	13	46	47	19	0	0.915	1.000	1.000
404	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(3), ABL2(1), AKT1(1), AKT2(2), AKT3(2), BRAF(5), BTC(1), CAMK2D(1), CAMK2G(2), CBL(2), CBLB(3), CBLC(1), CDKN1A(1), EGF(3), EGFR(4), ELK1(1), ERBB2(3), ERBB3(5), ERBB4(7), GAB1(1), GSK3B(1), HBEGF(1), JUN(1), KRAS(4), MAP2K1(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(1), MAPK9(1), NRAS(1), NRG1(2), NRG2(2), NRG3(2), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PLCG2(2), PRKCG(1), PTK2(1), RPS6KB1(2), RPS6KB2(1), SHC1(2), SHC2(1), SOS1(4), SOS2(1), SRC(1), STAT5A(2)	45403862	123	96	122	41	9	14	47	40	13	0	0.353	1.000	1.000
405	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(1), ADCY2(1), ADCY3(1), ADCY5(3), ADCY6(2), ADCY8(5), ADCY9(3), CACNA1C(8), CACNA1D(6), CACNA1F(4), CACNA1S(8), CALM1(2), CALM2(1), CAMK2D(1), CAMK2G(2), CDC42(2), EGFR(4), ELK1(1), GNA11(1), GNAS(3), GNRH2(1), HBEGF(1), ITPR1(2), ITPR2(7), ITPR3(1), JUN(1), KRAS(4), MAP2K1(1), MAP2K3(2), MAP2K7(1), MAP3K1(3), MAP3K2(2), MAP3K4(6), MAPK1(1), MAPK10(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(1), MAPK9(1), MMP14(1), MMP2(1), NRAS(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLD1(3), PRKACA(1), PRKACB(1), PRKACG(2), PRKCD(1), PRKX(1), PTK2B(2), SOS1(4), SOS2(1), SRC(1)	56341636	130	96	130	46	20	8	36	51	15	0	0.644	1.000	1.000
406	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	BID(1), BRAF(5), FAS(3), FCGR3A(1), FCGR3B(1), FYN(1), HLA-B(1), HLA-E(2), ICAM2(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR1(1), IFNAR2(1), IFNGR1(1), ITGAL(3), ITGB2(1), KIR3DL1(2), KLRC1(2), KLRC2(2), KLRC3(1), KLRD1(1), KRAS(4), LCP2(1), MAP2K1(1), MAPK1(1), MAPK3(1), MICA(1), MICB(1), NCR2(1), NFAT5(3), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), NRAS(1), PAK1(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PLCG2(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKCG(1), PTK2B(2), PTPN11(1), PTPN6(1), RAC3(1), SH3BP2(1), SHC1(2), SHC2(1), SOS1(4), SOS2(1), SYK(1), TNFRSF10A(1), ULBP2(1), VAV1(2), VAV2(3), VAV3(2), ZAP70(2)	50207021	121	95	119	48	10	8	39	48	16	0	0.814	1.000	1.000
407	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(5), ABCA10(2), ABCA12(6), ABCA13(13), ABCA2(2), ABCA3(1), ABCA4(9), ABCA5(3), ABCA6(3), ABCA7(7), ABCA8(3), ABCA9(2), ABCB1(9), ABCB11(2), ABCB4(1), ABCB5(3), ABCB6(1), ABCB8(1), ABCC1(3), ABCC10(3), ABCC11(3), ABCC12(2), ABCC2(2), ABCC3(1), ABCC4(3), ABCC5(1), ABCC6(3), ABCC8(1), ABCC9(4), ABCD2(1), ABCD3(2), ABCD4(4), ABCG1(2), ABCG2(1), ABCG4(2), ABCG5(1), ABCG8(3), CFTR(4), TAP1(1), TAP2(1)	52374263	121	93	121	38	8	3	39	61	10	0	0.381	1.000	1.000
408	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA2A(2), ADORA3(1), ADRA1A(1), ADRB2(1), AGTR1(1), AGTR2(1), AVPR1A(2), AVPR2(1), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(1), CCKBR(1), CCR4(1), CCR6(1), CHML(2), CHRM2(3), CHRM3(2), CHRM5(1), CMKLR1(1), CNR1(1), CNR2(1), CX3CR1(1), CXCR4(1), DRD1(1), DRD2(1), DRD3(1), DRD5(3), EDNRB(1), F2RL2(1), FPR1(2), GALR1(1), GALT(2), GPR17(1), GPR174(2), GPR35(1), GPR37(3), GPR37L1(1), GPR4(1), GPR50(1), GPR63(1), GPR77(1), GPR83(2), GPR85(2), HCRTR2(1), HTR1A(2), HTR1E(3), HTR2A(2), HTR2C(1), HTR5A(1), HTR7(1), LHCGR(1), LTB4R(1), MAS1(1), MC3R(1), MC4R(1), MTNR1B(1), NMUR2(2), NPY2R(1), NTSR1(1), OPRD1(3), OPRL1(2), OPRM1(3), OR12D3(2), OR1C1(1), OR1F1(1), OR1Q1(1), OR5V1(2), OR7A5(1), OR8B8(1), P2RY10(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(1), P2RY6(1), PTGER2(1), PTGFR(1), PTGIR(1), RGR(1), SSTR1(1), SSTR3(1), SSTR4(1), TBXA2R(1), TRHR(2)	53334330	114	92	114	41	25	14	24	46	5	0	0.486	1.000	1.000
409	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(1), ADCY2(1), ADCY3(1), ADCY5(3), ADCY6(2), ADCY8(5), ADSL(1), AK2(1), ALLC(3), AMPD1(1), AMPD2(1), ATIC(1), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), ENPP3(2), ENTPD2(1), GDA(2), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), HPRT1(1), IMPDH1(2), IMPDH2(1), NPR1(1), NPR2(1), NT5M(1), PAICS(2), PAPSS1(2), PAPSS2(1), PDE4A(3), PDE4B(1), PDE4C(3), PDE4D(1), PDE5A(2), PDE6B(1), PDE6C(2), PDE8A(3), PFAS(1), POLB(2), POLD1(3), POLD2(1), POLE(4), POLG(2), POLL(1), POLQ(6), POLR1B(2), POLR2A(5), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RRM1(1), RRM2(1)	56611806	110	92	109	32	16	4	32	42	16	0	0.277	1.000	1.000
410	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(1), ADCY2(1), ADCY3(1), ADCY5(3), ADCY6(2), ADCY8(5), ADCY9(3), AKAP1(1), AKAP10(1), AKAP11(3), AKAP12(1), AKAP3(1), AKAP4(2), AKAP6(4), AKAP7(1), AKAP9(10), ARHGEF1(1), CALM1(2), CALM2(1), GNA11(1), GNA13(2), GNA14(1), GNAI2(1), GNAO1(1), GNB1(2), GNB5(1), GNG3(1), IL18BP(1), ITPR1(2), KCNJ3(3), KRAS(4), NRAS(1), PDE1B(2), PDE1C(2), PDE4A(3), PDE4B(1), PDE4C(3), PDE4D(1), PDE8A(3), PLCB3(1), PPP3CC(2), PRKACA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), PRKCD(1), PRKCE(4), PRKCG(1), PRKCH(3), PRKCI(3), PRKCQ(1), PRKD1(4), PRKD3(1), SLC9A1(2), USP5(1)	51552636	111	91	109	40	13	0	34	50	14	0	0.710	1.000	1.000
411	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(3), AMY2A(1), AMY2B(3), ASCC3(4), ATP13A2(1), DDX18(3), DDX23(1), DDX4(3), DDX47(1), DDX50(4), DDX52(1), DDX54(1), DHX58(1), ENPP3(2), EP400(3), ERCC2(1), ERCC3(1), G6PC(1), GAA(2), GANC(1), GBA(1), GBA3(2), GPI(1), GUSB(2), GYS1(2), GYS2(1), IFIH1(2), MOV10L1(4), PYGB(1), PYGL(1), PYGM(2), RAD54L(3), RUVBL2(2), SETX(5), SI(8), SKIV2L2(1), SMARCA2(3), SMARCA5(2), TREH(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2A1(3), UGT2A3(4), UGT2B10(7), UGT2B11(2), UGT2B15(1), UGT2B7(2), UXS1(1)	54771122	114	90	112	53	8	8	31	49	18	0	0.967	1.000	1.000
412	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(1), AKT2(2), AKT3(2), BCL10(1), CARD11(3), CBL(2), CBLB(3), CBLC(1), CD28(2), CD3E(1), CD3G(1), CD4(1), CD8B(1), CDC42(2), CDK4(1), FYN(1), GRAP2(1), IKBKB(1), JUN(1), KRAS(4), LCP2(1), MALT1(2), MAP3K14(1), NFAT5(3), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), NRAS(1), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PDK1(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKCQ(1), PTPN6(1), PTPRC(6), SOS1(4), SOS2(1), TEC(3), VAV1(2), VAV2(3), VAV3(2), ZAP70(2)	44796397	112	90	111	30	9	10	33	50	10	0	0.191	1.000	1.000
413	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(1), ADCY8(5), BRAF(5), CACNA1C(8), CALM1(2), CALM2(1), CAMK2D(1), CAMK2G(2), CREBBP(4), EP300(6), GRIA1(4), GRIA2(1), GRIN1(2), GRIN2A(3), GRIN2B(11), GRM1(4), GRM5(3), ITPR1(2), ITPR2(7), ITPR3(1), KRAS(4), MAP2K1(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PPP1CB(1), PPP1R12A(4), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKACA(1), PRKACB(1), PRKACG(2), PRKCG(1), PRKX(1), RAP1B(2), RAPGEF3(1), RPS6KA1(2), RPS6KA2(1), RPS6KA6(3)	44232745	111	90	111	36	14	9	35	43	10	0	0.322	1.000	1.000
414	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1B(3), AKT1(1), BMPR2(4), BUB1(2), CDKL1(1), CDS2(1), CLK1(3), CLK2(1), CLK4(2), DGKB(1), DGKG(2), DGKH(4), DGKQ(1), DGKZ(2), INPP4A(1), INPP4B(3), INPP5A(1), INPPL1(1), ITPKA(1), ITPKB(2), MAP3K10(2), NEK1(2), NEK3(2), OCRL(2), PAK4(2), PIK3C2A(2), PIK3C2G(1), PIK3CA(14), PIK3CB(2), PIK3CG(5), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCG2(2), PLK3(1), PRKACA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), PRKCD(1), PRKCE(4), PRKCG(1), PRKCH(3), PRKCQ(1), PRKD1(4), PRKG1(2), RPS6KA1(2), RPS6KA2(1), RPS6KB1(2)	50086846	109	90	106	41	13	4	37	35	20	0	0.676	1.000	1.000
415	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(2), CLK2(1), CLK3(1), CLK4(2), COL2A1(5), CPSF1(2), CPSF3(2), CPSF4(2), CSTF2T(2), CSTF3(2), DDX1(1), DDX20(4), DHX15(5), DHX8(1), DHX9(3), DICER1(1), DNAJC8(1), FUS(1), LOC440563(1), LSM7(1), METTL3(4), NONO(3), NXF1(2), PABPN1(1), PAPOLA(3), POLR2A(5), PRPF3(1), PRPF4B(1), PRPF8(7), PTBP2(1), RBM17(2), RNMT(1), SF3A1(1), SF3A3(2), SF3B1(4), SF3B2(2), SF4(2), SFRS12(3), SFRS14(1), SFRS16(1), SFRS2(1), SFRS4(2), SFRS5(1), SFRS7(1), SNRPB(1), SNRPF(1), SNRPN(2), SPOP(1), SRPK2(1), SRRM1(1), SUPT5H(4), XRN2(5)	46614015	108	86	108	25	9	7	34	47	11	0	0.0648	1.000	1.000
416	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(5), CACNA1A(1), GNA11(1), GNA13(2), GNAI1(2), GNAI2(1), GNAO1(1), GNAS(3), GRIA1(4), GRIA2(1), GRIA3(1), GRID2(5), GRM1(4), GRM5(3), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), IGF1(1), IGF1R(1), ITPR1(2), ITPR2(7), ITPR3(1), KRAS(4), LYN(1), MAP2K1(1), MAPK1(1), MAPK3(1), NOS1(7), NOS3(1), NPR1(1), NPR2(1), NRAS(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PPP2CA(1), PPP2CB(1), PPP2R1B(1), PPP2R2A(1), PPP2R2B(3), PRKCG(1), PRKG1(2), PRKG2(3), RYR1(12)	48673514	108	85	108	58	15	8	27	47	11	0	0.998	1.000	1.000
417	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1B(3), ACVR1C(2), ACVR2A(3), ACVR2B(1), AMHR2(1), BMP5(2), BMP6(1), BMP7(1), BMPR1B(1), BMPR2(4), CHRD(2), CREBBP(4), CUL1(3), DCN(2), E2F4(1), E2F5(1), EP300(6), GDF5(1), GDF6(1), INHBA(1), LTBP1(5), MAPK1(1), MAPK3(1), PITX2(2), PPP2CA(1), PPP2CB(1), PPP2R1B(1), PPP2R2A(1), PPP2R2B(3), RBL2(3), ROCK1(3), ROCK2(3), RPS6KB1(2), RPS6KB2(1), SMAD2(3), SMAD4(3), SMAD9(2), SMURF1(1), SMURF2(2), SP1(1), TGFB2(1), TGFBR2(1), THBS1(5), THBS2(2), THBS3(3), THBS4(1), ZFYVE16(5), ZFYVE9(2)	43640391	101	84	101	33	8	7	29	42	15	0	0.484	1.000	1.000
418	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(5), BDKRB1(1), BDKRB2(1), C1R(1), C1S(2), C3(5), C3AR1(1), C4BPA(2), C5(2), C6(4), C7(2), C8B(1), CD55(2), CFH(4), CFI(2), CR1(11), CR2(1), F11(1), F12(1), F13A1(1), F13B(2), F2(2), F5(5), F8(4), FGA(2), FGB(1), FGG(2), KLKB1(1), KNG1(2), MASP1(1), MBL2(1), PLAT(1), PLAU(4), PLAUR(1), PLG(1), PROC(2), PROS1(5), SERPINA1(2), SERPIND1(1), SERPINF2(2), SERPING1(2), TFPI(1), VWF(6)	40009129	101	81	98	32	14	4	26	42	15	0	0.407	1.000	1.000
419	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA2(1), INPP4A(1), INPP4B(3), INPP5A(1), INPP5B(3), INPPL1(1), ITPKA(1), ITPKB(2), MIOX(2), OCRL(2), PI4KA(9), PI4KB(2), PIK3C3(4), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIP4K2A(1), PIP4K2C(1), PIP5K1C(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCD4(2), PLCE1(3), PLCG2(2), PTEN(16), SYNJ1(4), SYNJ2(3)	32801227	94	80	93	30	7	6	29	30	22	0	0.466	1.000	1.000
420	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(1), ADCY2(1), ADCY3(1), ADCY5(3), ADCY6(2), ADCY8(5), ADCY9(3), CALM1(2), CALM2(1), CAMK2D(1), CAMK2G(2), CREB3L3(1), CREB3L4(1), CREBBP(4), CTNNB1(2), DCT(2), DVL1(1), EDNRB(1), EP300(6), FZD1(2), FZD10(2), FZD2(1), FZD3(1), FZD4(1), FZD5(1), FZD6(1), GNAI1(2), GNAI2(1), GNAO1(1), GNAS(3), GSK3B(1), KITLG(2), KRAS(4), LEF1(1), MAP2K1(1), MAPK1(1), MAPK3(1), MITF(2), NRAS(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PRKACA(1), PRKACB(1), PRKACG(2), PRKCG(1), PRKX(1), TCF7(2), TCF7L2(1), TYR(1), TYRP1(1), WNT16(1), WNT2(2), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1), WNT9A(1)	47941559	95	80	94	41	8	5	31	42	9	0	0.895	1.000	1.000
421	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(1), ALG10(1), ALG10B(2), ALG13(3), ALG2(1), ALG8(2), B3GNT1(1), B3GNT2(2), B3GNT6(1), B3GNT7(1), B4GALT5(1), C1GALT1(1), C1GALT1C1(1), CHST11(1), CHST4(2), CHST7(1), DDOST(1), DPAGT1(2), EXT1(1), EXTL1(1), EXTL2(1), EXTL3(2), FUT11(1), GALNT1(1), GALNT10(2), GALNT11(2), GALNT13(3), GALNT4(1), GALNT5(5), GALNT7(3), GALNT8(3), GALNT9(1), GALNTL2(1), GALNTL5(2), GANAB(1), GCNT1(2), GCNT4(1), HS2ST1(1), HS3ST2(1), HS3ST3A1(1), HS3ST5(1), HS6ST3(1), MAN2A1(2), MGAT3(1), MGAT4A(3), MGAT5(3), MGAT5B(1), NDST1(1), NDST2(2), NDST3(1), NDST4(3), OGT(3), RPN1(1), RPN2(2), ST3GAL1(1), ST3GAL3(1), ST6GALNAC1(1), STT3B(2), WBSCR17(4), XYLT1(1), XYLT2(2)	48572499	99	79	99	38	9	4	31	45	10	0	0.791	1.000	1.000
422	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(1), BRAF(5), DAXX(4), ELK1(1), IKBKB(1), JUN(1), MAP2K1(1), MAP2K3(2), MAP2K7(1), MAP3K1(3), MAP3K10(2), MAP3K11(1), MAP3K12(1), MAP3K13(1), MAP3K14(1), MAP3K2(2), MAP3K4(6), MAP3K5(4), MAP3K6(2), MAP3K7(2), MAP3K9(1), MAP4K3(2), MAP4K4(2), MAPK1(1), MAPK10(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(1), MAPK6(3), MAPK7(1), MAPK8(1), MAPK9(1), MAX(3), MEF2A(2), MEF2C(2), MEF2D(1), MKNK1(1), MKNK2(2), PAK1(1), PAK2(2), RELA(1), RIPK1(2), RPS6KA1(2), RPS6KA2(1), RPS6KB1(2), RPS6KB2(1), SHC1(2), SP1(1), STAT1(2), TGFB2(1), TRADD(1)	42255034	91	76	91	28	10	10	26	28	17	0	0.335	1.000	1.000
423	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(1), ATM(14), ATR(5), BAI1(1), BID(1), CCNB2(5), CCNB3(4), CCND2(1), CCNE1(1), CCNG2(2), CD82(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(3), CHEK1(1), CHEK2(7), FAS(3), GTSE1(1), IGF1(1), LRDD(1), PTEN(16), RFWD2(2), RRM2(1), SERPINB5(3), STEAP3(1), THBS1(5), TP53(13), TP53I3(2), TP73(1), TSC2(2)	28841803	102	75	99	34	9	4	40	30	19	0	0.389	1.000	1.000
424	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	CABIN1(4), CALM1(2), CALM2(1), CD3E(1), CD3G(1), CDKN1A(1), CNR1(1), CREBBP(4), EP300(6), FCGR3A(1), GATA4(1), GRLF1(3), GSK3A(1), GSK3B(1), IFNA1(1), IL2RA(2), IL3(1), KPNA5(2), MAP2K7(1), MAPK14(1), MAPK8(1), MAPK9(1), MEF2A(2), MEF2D(1), NFAT5(3), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), NPPB(1), NUP214(2), OPRD1(3), PAK1(1), PPP3CB(1), PPP3CC(2), PPP3R1(1), PTPRC(6), RELA(1), SP1(1), SP3(1), TRPV6(1), VAV1(2), VAV2(3), VAV3(2), XPO5(2)	40090251	82	74	82	28	9	4	29	31	9	0	0.498	1.000	1.000
425	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(1), AKT2(2), AKT3(2), CDC42(2), KDR(5), KRAS(4), MAP2K1(1), MAPK1(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), NFAT5(3), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), NOS3(1), NRAS(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PLA2G12A(1), PLA2G4A(1), PLA2G6(1), PLCG2(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKCG(1), PTGS2(4), PTK2(1), PXN(2), RAC3(1), SHC2(1), SPHK2(1), SRC(1)	31806814	82	68	81	29	6	6	26	33	11	0	0.618	1.000	1.000
426	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(1), AKT2(2), AKT3(2), FYN(1), GAB2(1), IL3(1), INPP5D(1), KRAS(4), LCP2(1), LYN(1), MAP2K1(1), MAP2K3(2), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(1), MAPK9(1), NRAS(1), PDK1(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PLA2G12A(1), PLA2G4A(1), PLA2G6(1), PLCG2(2), PRKCD(1), PRKCE(4), RAC3(1), SOS1(4), SOS2(1), SYK(1), VAV1(2), VAV2(3), VAV3(2)	31864345	80	68	78	26	8	8	25	27	12	0	0.363	1.000	1.000
427	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(14), CCNA1(1), CCND2(1), CCNE1(1), CCNG2(2), CCNH(1), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(3), CDKN2C(1), CREB3L3(1), CREB3L4(1), E2F4(1), E2F5(1), E2F6(1), GBA2(2), MCM2(3), MCM5(1), MCM6(1), MCM7(6), NACA(1), ORC1L(2), ORC3L(1), ORC4L(1), ORC5L(1), ORC6L(1), PCNA(2), POLE(4), PRIM1(1), RB1(2), RPA2(1), RPA3(1), TFDP2(3), TNXB(2), TP53(13)	34092726	82	63	82	42	7	3	27	30	15	0	0.977	1.000	1.000
428	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	DOCK1(5), ELK1(1), GAB1(1), HGF(1), ITGA1(4), ITGB1(2), JUN(1), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(1), MET(5), PAK1(1), PIK3CA(14), PIK3R1(1), PTEN(16), PTK2(1), PTK2B(2), PTPN11(1), PXN(2), RAP1B(2), RASA1(2), SOS1(4), SRC(1), STAT3(1)	19548558	72	61	71	23	2	6	32	23	9	0	0.374	1.000	1.000
429	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(1), CAD(2), CASP10(2), CASP8AP2(4), CD7(1), CSNK1A1(1), DAXX(4), DEDD(1), EGFR(4), EPHB2(1), FAF1(1), MAP2K7(1), MAP3K1(3), MAP3K5(4), MAPK1(1), MAPK10(2), MAPK8(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MET(5), NFAT5(3), NFKBIL2(2), PTPN13(7), RALBP1(1), RIPK1(2), ROCK1(3), SMPD1(1), TP53(13), TPX2(2)	32450659	78	60	78	31	6	6	20	33	13	0	0.822	1.000	1.000
430	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(1), CAD(2), DCTD(1), DPYD(1), DPYS(1), DUT(1), ENTPD4(1), ENTPD6(1), NME7(1), NT5C1B(1), NT5C3(1), NT5M(1), POLA1(2), POLD1(3), POLD2(1), POLE(4), POLR1A(1), POLR1B(2), POLR2A(5), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(2), POLR3B(4), POLR3G(2), POLR3H(1), PRIM1(1), PRIM2(5), RRM1(1), RRM2(1), TK1(1), TXNRD1(3), TXNRD2(1), UCK1(1), UMPS(1), UPB1(1), UPP2(2), UPRT(2)	35881620	66	59	63	27	5	7	25	18	9	2	0.709	1.000	1.000
431	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(5), CPEB1(4), EGFR(4), ERBB2(3), ERBB4(7), ETS1(1), ETV6(1), FMN2(8), KRAS(4), MAP2K1(1), MAPK1(1), MAPK3(1), NOTCH1(4), NOTCH2(5), NOTCH3(3), PIWIL1(2), PIWIL2(2), PIWIL3(1), PIWIL4(1), SOS1(4), SOS2(1), SPIRE1(1), SPIRE2(2)	22998674	66	59	65	24	6	5	20	25	10	0	0.784	1.000	1.000
432	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(4), ACSL1(2), ACSL3(1), ACSL4(1), ACSL5(2), ACSL6(4), AKT1(1), AKT2(2), AKT3(2), CAMKK1(1), CAMKK2(1), CPT1A(1), G6PC(1), IKBKB(1), IRS1(3), IRS2(1), JAK1(4), JAK2(5), JAK3(2), LEPR(1), MAPK10(2), MAPK8(1), MAPK9(1), PCK1(2), PCK2(2), PPARGC1A(1), PRKAA1(1), PRKAG1(1), PRKAG2(1), PRKCQ(1), PTPN11(1), RELA(1), RXRB(3), RXRG(1), STAT3(1), TNFRSF1A(2), TRADD(1), TYK2(3)	36548449	66	59	66	24	5	8	19	26	8	0	0.675	1.000	1.000
433	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	CREBBP(4), DUT(1), EHHADH(2), EP300(6), FABP1(1), HSD17B4(1), JUN(1), LPL(1), MAPK1(1), MAPK3(1), ME1(1), NCOA1(2), NCOR1(6), NCOR2(3), NR1H3(1), NRIP1(3), PDGFA(1), PIK3CA(14), PIK3R1(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), PTGS2(4), RB1(2), RELA(1), SP1(1), SRA1(1), STAT5A(2)	27854453	68	59	67	27	3	7	28	24	6	0	0.624	1.000	1.000
434	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(14), ATR(5), BRCA1(3), BRCA2(9), CHEK1(1), CHEK2(7), FANCA(4), FANCD2(2), FANCE(3), FANCF(2), FANCG(3), HUS1(1), RAD17(2), RAD50(2), RAD51(2), TP53(13), TREX1(1)	19433571	74	56	71	30	6	3	29	25	11	0	0.796	1.000	1.000
435	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADM(1), ACOX2(1), ACOX3(3), ACSL1(2), ACSL3(1), ACSL4(1), ACSL5(2), ACSL6(4), ANGPTL4(1), APOA5(1), AQP7(1), CPT1A(1), CYP27A1(1), CYP4A11(4), CYP8B1(3), DBI(1), EHHADH(2), FABP1(1), FABP6(1), FADS2(2), GK(1), HMGCS2(1), LPL(1), ME1(1), NR1H3(1), PCK1(2), PCK2(2), PLTP(2), PPARG(1), RXRB(3), RXRG(1), SCP2(2), SLC27A1(2), SLC27A4(1), SLC27A5(2), SLC27A6(3), SORBS1(1), UBC(3), UCP1(1)	28824062	65	56	65	23	7	9	21	23	5	0	0.540	1.000	1.000
436	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(6), B3GALT4(1), DGKI(1), FAU(1), IL6ST(3), PIGK(1), RPL11(1), RPL15(1), RPL18(2), RPL18A(1), RPL19(1), RPL22(1), RPL27(1), RPL28(2), RPL3(1), RPL30(2), RPL31(1), RPL34(1), RPL3L(1), RPL4(1), RPL5(2), RPL7(1), RPL9(1), RPLP0(1), RPS11(1), RPS13(1), RPS2(1), RPS21(1), RPS24(1), RPS26(2), RPS27(1), RPS29(1), RPS3(1), RPS3A(1), RPS4Y1(1), RPS6KA1(2), RPS6KA2(1), RPS6KA6(3), RPS6KB1(2), RPS6KB2(1), TBC1D10C(1), TSPAN9(1), UBC(3)	23288024	61	55	61	17	6	3	19	24	9	0	0.295	1.000	1.000
437	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP5(2), BMP6(1), BMP7(1), CSNK1A1(1), CSNK1E(2), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), FBXW11(1), GAS1(1), GLI1(1), GLI2(3), GLI3(4), GSK3B(1), HHIP(1), LRP2(8), PRKACA(1), PRKACB(1), PRKACG(2), PRKX(1), PTCH1(5), SHH(1), SMO(3), STK36(3), WNT16(1), WNT2(2), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1), WNT9A(1)	26812741	55	54	55	22	9	4	15	23	4	0	0.807	1.000	1.000
438	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(1), AASS(5), AKR1B10(3), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), BBOX1(1), DLST(2), DOT1L(3), ECHS1(1), EHHADH(2), EHMT1(1), EHMT2(2), GCDH(1), HADH(1), HADHA(1), HSD17B4(1), NSD1(5), OGDH(1), OGDHL(2), PLOD2(3), PLOD3(2), RDH11(2), SETD1A(1), SETDB1(3), SHMT1(2), SHMT2(2), SPCS1(2), SUV39H2(3), TMLHE(1)	25609341	61	53	61	21	8	8	17	17	11	0	0.497	1.000	1.000
439	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(4), ATP6V0A1(3), ATP6V0A4(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(2), CDC42(2), CSK(2), EGFR(4), F11R(1), HBEGF(1), IKBKB(1), JAM2(1), JUN(1), LYN(1), MAP3K14(1), MAPK10(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK8(1), MAPK9(1), MET(5), NOD1(2), PAK1(1), PLCG2(2), PTPN11(1), PTPRZ1(9), RELA(1), SRC(1), TJP1(4)	30870945	65	53	65	20	2	4	26	30	3	0	0.411	1.000	1.000
440	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(14), ATR(5), BRCA1(3), CDC25A(1), CDC25C(2), CDKN1A(1), CHEK1(1), CHEK2(7), EP300(6), PRKDC(5), RPS6KA1(2), TP53(13)	18713605	60	51	57	26	5	4	22	19	10	0	0.818	1.000	1.000
441	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(2), CALM2(1), CD3E(1), CD3G(1), ELK1(1), FYN(1), JUN(1), MAP2K1(1), MAP3K1(3), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), PIK3CA(14), PIK3R1(1), PPP3CB(1), PPP3CC(2), PTPN7(1), RASA1(2), RELA(1), SHC1(2), SOS1(4), SYT1(1), VAV1(2), ZAP70(2)	21015565	55	51	54	21	7	6	18	18	6	0	0.641	1.000	1.000
442	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(2), CALR(1), CANX(3), CD4(1), CD74(1), CD8B(1), CIITA(1), CTSB(4), CTSS(1), HLA-B(1), HLA-DMB(1), HLA-DPA1(1), HLA-DRA(1), HLA-E(2), HLA-F(1), HSP90AA1(5), HSP90AB1(2), HSPA5(2), IFI30(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), KIR3DL1(2), KIR3DL3(1), KLRC1(2), KLRC2(2), KLRC3(1), KLRD1(1), LGMN(1), LTA(1), RFX5(1), TAP1(1), TAP2(1)	20607714	53	50	52	22	4	2	16	28	3	0	0.887	1.000	1.000
443	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(6), AXIN1(1), CCND2(1), CSNK1E(2), CTNNB1(2), DVL1(1), FZD1(2), FZD10(2), FZD2(1), FZD3(1), FZD5(1), FZD6(1), GSK3B(1), JUN(1), MAPK10(2), MAPK9(1), PAFAH1B1(1), PLAU(4), PRKCD(1), PRKCE(4), PRKCG(1), PRKCH(3), PRKCI(3), PRKCQ(1), PRKD1(4), SFRP4(2), TCF7(2), WNT16(1), WNT2(2), WNT5B(1), WNT7B(1)	26367143	57	50	54	31	4	5	18	20	10	0	0.969	1.000	1.000
444	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(1), ALPP(3), ALPPL2(1), ASCC3(4), ATP13A2(1), DDX18(3), DDX23(1), DDX4(3), DDX47(1), DDX50(4), DDX52(1), DDX54(1), DHFR(1), DHX58(1), EP400(3), ERCC2(1), ERCC3(1), FPGS(1), GGH(1), IFIH1(2), MOV10L1(4), QDPR(1), RAD54L(3), RUVBL2(2), SETX(5), SKIV2L2(1), SMARCA2(3), SMARCA5(2)	27726108	58	49	58	24	3	6	16	23	10	0	0.783	1.000	1.000
445	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(1), APC(6), AR(1), BRAF(5), EGFR(4), GNA11(1), GNAI1(2), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(1), KCNJ3(3), MAPK1(1), MAPK10(2), MAPK14(1), PHKA2(1), PIK3CA(14), PIK3CD(1), PIK3R1(1), PITX2(2), SRC(1)	23571933	60	49	59	25	9	7	21	17	6	0	0.652	1.000	1.000
446	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	CALM1(2), CALM2(1), ELK1(1), JUN(1), LYN(1), MAP2K1(1), MAP2K7(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), PAK2(2), PIK3CA(14), PIK3R1(1), PLA2G4A(1), PPP3CB(1), PPP3CC(2), SHC1(2), SOS1(4), SYK(1), SYT1(1), VAV1(2)	18913806	53	48	52	19	6	6	18	16	7	0	0.531	1.000	1.000
447	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADHFE1(1), AKR1C1(1), AKR1C4(1), ALDH3B1(2), ALDH3B2(1), CYP1A1(1), CYP1A2(2), CYP2B6(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(2), CYP2F1(1), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(1), DHDH(1), EPHX1(3), GSTA3(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2A1(3), UGT2A3(4), UGT2B10(7), UGT2B11(2), UGT2B15(1), UGT2B7(2)	25263220	60	48	58	23	6	7	17	23	7	0	0.672	1.000	1.000
448	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(4), CTBP1(1), DLL3(1), DLL4(2), DTX1(1), DTX3L(1), DTX4(1), DVL1(1), EP300(6), HDAC1(1), JAG1(2), JAG2(2), MAML1(2), MAML2(2), MAML3(3), NCOR2(3), NOTCH1(4), NOTCH2(5), NOTCH3(3), NUMB(2), NUMBL(1), PSEN2(1), PSENEN(1), RBPJ(2), RBPJL(1), SNW1(1)	30652863	54	48	54	28	6	2	18	20	8	0	0.951	1.000	1.000
449	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(1), AKT2(2), AKT3(2), BRAF(5), DRD2(1), EGFR(4), EPHB2(1), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(1), KCNJ3(3), MAPK1(1), PIK3CB(2), PITX2(2), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), SHC1(2), SOS1(4), SOS2(1), SRC(1), STAT3(1)	25832269	52	48	52	21	9	4	18	17	4	0	0.724	1.000	1.000
450	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(1), ATF2(1), CDC42(2), DLD(4), DUSP10(1), GAB1(1), JUN(1), MAP2K7(1), MAP3K1(3), MAP3K10(2), MAP3K11(1), MAP3K12(1), MAP3K13(1), MAP3K2(2), MAP3K4(6), MAP3K5(4), MAP3K7(2), MAP3K9(1), MAPK10(2), MAPK7(1), MAPK8(1), MAPK9(1), NFATC3(3), PAPPA(1), SHC1(2), TP53(13), ZAK(2)	22168761	61	48	61	20	6	5	18	21	11	0	0.478	1.000	1.000
451	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(4), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), AOC2(1), AOC3(1), AOX1(4), CAT(2), CYP19A1(3), CYP1A1(1), CYP1A2(2), CYP2A13(3), CYP2B6(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(2), CYP2F1(1), CYP2J2(1), CYP3A4(1), CYP3A5(1), CYP3A7(1), CYP4B1(1), DDC(3), ECHS1(1), EHHADH(2), GCDH(1), HADHA(1), MAOA(1), MAOB(1), TPH1(3), WARS2(2)	24277780	54	48	54	20	7	3	20	22	2	0	0.559	1.000	1.000
452	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY6(2), ADCY8(5), CACNA1A(1), CACNA1B(3), GNAS(3), GNB1(2), GNG3(1), GRM4(2), ITPR3(1), KCNB1(1), PLCB2(1), PRKACA(1), PRKACB(1), PRKACG(2), PRKX(1), SCNN1A(2), SCNN1B(2), SCNN1G(1), TAS1R2(2), TAS1R3(2), TAS2R1(1), TAS2R38(1), TAS2R39(1), TAS2R40(1), TAS2R42(2), TAS2R46(1), TAS2R50(2), TAS2R60(1), TAS2R7(1), TAS2R8(1), TAS2R9(1)	25266577	49	47	49	14	11	1	11	17	9	0	0.357	1.000	1.000
453	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3L1(1), CAD(2), DCTD(1), DPYD(1), DPYS(1), DUT(1), NT5M(1), POLB(2), POLD1(3), POLD2(1), POLE(4), POLG(2), POLL(1), POLQ(6), POLR1B(2), POLR2A(5), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1), RRM1(1), RRM2(1), TK1(1), TXNRD1(3), UCK1(1), UMPS(1), UPB1(1)	25281471	50	47	50	17	5	5	15	19	6	0	0.509	1.000	1.000
454	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(1), CDK2(1), CDT1(1), DIAPH2(4), MCM10(3), MCM2(3), MCM5(1), MCM6(1), MCM7(6), NACA(1), ORC1L(2), ORC3L(1), ORC4L(1), ORC5L(1), ORC6L(1), PCNA(2), POLD1(3), POLD2(1), POLE(4), PRIM1(1), RFC1(2), RFC4(3), RPA2(1), RPA3(1), RPA4(1), UBC(3)	22456358	51	46	51	17	6	1	16	19	9	0	0.519	1.000	1.000
455	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(2), ACTR3(1), AKT1(1), GCA(1), ITGA9(2), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(1), MAP2K1(1), MAPK1(1), MAPK3(1), NR1I3(1), PAK1(1), PDE3A(3), PDE3B(3), PIK3C2G(1), PIK3CA(14), PIK3CD(1), PIK3R1(1), RIPK3(1)	21603402	49	46	48	16	7	6	16	16	4	0	0.404	1.000	1.000
456	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(1), CCKBR(1), CELSR1(3), CELSR2(4), CELSR3(4), CHRM2(3), CHRM3(2), EMR3(6), GHRHR(1), GPR116(2), GPR133(1), GPR17(1), GPR56(1), GPR61(1), GPR77(1), GPR84(2), GRM1(4), HRH4(1), LGR6(1), LPHN2(2), LPHN3(4), NTSR1(1), OR2M4(1), OR8G2(2), P2RY13(1), PTGFR(1), SMO(3)	29367292	55	45	55	19	9	4	18	22	2	0	0.391	1.000	1.000
457	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(4), APAF1(1), ARHGDIB(1), BAG4(1), BID(1), BIRC2(2), BIRC3(2), CASP2(2), CASP7(1), CFLAR(1), DAXX(4), GSN(1), LMNA(1), MAP2K7(1), MAP3K1(3), MAP3K14(1), MAP3K5(4), MAPK8(1), NUMA1(1), PAK2(2), PRKCD(1), PRKDC(5), PSEN2(1), PTK2(1), RASA1(2), RB1(2), RELA(1), RIPK1(2), SPTAN1(3), TNFRSF1A(2), TRADD(1)	30804788	56	45	56	24	4	6	20	20	6	0	0.756	1.000	1.000
458	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(3), ACTG1(4), ARHGEF2(1), CDC42(2), CDH1(3), CTNNB1(2), FYN(1), HCLS1(1), ITGB1(2), NCL(2), ROCK1(3), ROCK2(3), TLR4(1), TLR5(1), TUBA1A(1), TUBA3C(1), TUBA3D(2), TUBA4A(2), TUBAL3(1), TUBB(1), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), TUBB6(1), WASL(5)	23089008	51	45	51	24	5	3	19	21	3	0	0.879	1.000	1.000
459	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(3), ACTG1(4), ARHGEF2(1), CDC42(2), CDH1(3), CTNNB1(2), FYN(1), HCLS1(1), ITGB1(2), NCL(2), ROCK1(3), ROCK2(3), TLR4(1), TLR5(1), TUBA1A(1), TUBA3C(1), TUBA3D(2), TUBA4A(2), TUBAL3(1), TUBB(1), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), TUBB6(1), WASL(5)	23089008	51	45	51	24	5	3	19	21	3	0	0.879	1.000	1.000
460	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	ELK1(1), JAK1(4), JUN(1), MAP2K1(1), MAP3K1(3), MAPK3(1), MAPK8(1), PDGFA(1), PDGFRA(6), PIK3CA(14), PIK3R1(1), RASA1(2), SHC1(2), SOS1(4), STAT1(2), STAT3(1), STAT5A(2)	15338689	47	45	46	22	3	4	17	17	6	0	0.883	1.000	1.000
461	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(3), FYN(1), GSN(1), ITGA1(4), ITGB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), MYL2(1), MYLK(3), PIK3CA(14), PIK3R1(1), PTK2(1), PXN(2), ROCK1(3), SHC1(2), SRC(1), TLN1(6)	16440988	48	44	47	16	3	6	15	19	5	0	0.542	1.000	1.000
462	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGF(3), EGFR(4), ELK1(1), JAK1(4), JUN(1), MAP2K1(1), MAP3K1(3), MAPK3(1), MAPK8(1), PIK3CA(14), PIK3R1(1), RASA1(2), SHC1(2), SOS1(4), STAT1(2), STAT3(1), STAT5A(2)	16469635	47	43	46	19	3	4	19	13	8	0	0.748	1.000	1.000
463	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	DAXX(4), EGF(3), EGFR(4), ETS1(1), IKBKB(1), JUN(1), MAP2K1(1), MAP2K3(2), MAP2K7(1), MAP3K1(3), MAP3K14(1), MAP3K5(4), MAPK1(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(1), PPP2CA(1), PRKCD(1), PRKCE(4), PRKCG(1), PRKCH(3), PRKCQ(1), RELA(1), RIPK1(2), SP1(1), TNFRSF1A(2)	21595785	48	43	46	20	5	3	11	17	12	0	0.813	1.000	1.000
464	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	AGPAT6(2), CDS2(1), CHAT(2), CHKB(1), CHPT1(1), DGKB(1), DGKG(2), DGKH(4), DGKI(1), DGKQ(1), DGKZ(2), ESCO1(2), ETNK1(1), ETNK2(1), GNPAT(2), GPAM(1), LYPLA1(1), MYST3(6), MYST4(3), PCYT1B(1), PISD(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(1), PLD1(3), PNPLA3(1), PPAP2B(1), PTDSS1(2), SH3GLB1(1)	29017920	48	42	48	23	10	4	14	19	1	0	0.846	1.000	1.000
465	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(1), CBL(2), CFLAR(1), IL2RA(2), IL2RB(1), IRS1(3), JAK1(4), JAK3(2), MAPK1(1), MAPK3(1), PIK3CA(14), PIK3R1(1), PTPN6(1), RPS6KB1(2), SHC1(2), SOS1(4), STAT5A(2), SYK(1)	15912501	45	42	44	17	5	4	17	14	5	0	0.595	1.000	1.000
466	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4A(1), INPP4B(3), INPP5A(1), INPPL1(1), ITPKA(1), ITPKB(2), MIOX(2), OCRL(2), PIK3C2A(2), PIK3C2G(1), PIK3CA(14), PIK3CB(2), PIK3CG(5), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCG2(2)	19869516	46	42	45	18	4	3	14	16	9	0	0.785	1.000	1.000
467	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(1), ATF1(1), BRAF(5), CREBBP(4), EGR1(1), ELK1(1), FRS2(1), JUN(1), MAP1B(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), NTRK1(2), PIK3C2G(1), PIK3CA(14), PIK3CD(1), PIK3R1(1), PTPN11(1), SHC1(2), SRC(1)	22813930	50	42	49	26	5	5	19	16	5	0	0.936	1.000	1.000
468	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(2), CD28(2), CSK(2), EPHB2(1), FBXW7(4), GRAP2(1), ITPKA(1), ITPKB(2), LCP2(1), MAPK1(1), NFAT5(3), NFKBIL2(2), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PTPRC(6), RASGRP2(2), RASGRP4(2), SOS1(4), SOS2(1), VAV1(2), ZAP70(2)	24739593	49	42	49	22	7	6	12	21	3	0	0.900	1.000	1.000
469	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(3), AMY2A(1), AMY2B(3), ENPP3(2), G6PC(1), GAA(2), GANAB(1), GBA3(2), GPI(1), GUSB(2), GYS1(2), GYS2(1), PYGB(1), PYGL(1), PYGM(2), SI(8), UCHL3(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2B15(1), UXS1(1)	25271823	48	42	48	23	3	3	13	21	8	0	0.937	1.000	1.000
470	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(1), AZIN1(1), BTG1(1), CLOCK(3), EIF4G2(2), ETV6(1), HERPUD1(1), HSPA8(6), KLF9(2), MYF6(1), NCKAP1(2), NCOA4(4), PER1(5), PER2(3), PPP2CB(1), PSMA4(2), SF3A3(2), TOB1(1), TUBB3(3), ZFR(3)	16162603	45	41	45	16	4	4	14	16	7	0	0.500	1.000	1.000
471	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACADM(1), ACADS(2), ACOX3(3), ACSL1(2), ACSL3(1), ACSL4(1), ACSL5(2), ACSL6(4), ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADHFE1(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), CPT1A(1), CYP4A11(4), ECHS1(1), EHHADH(2), GCDH(1), HADH(1), HADHA(1), HADHB(1), HSD17B4(1), PECI(3)	21555151	43	41	42	16	6	9	15	8	5	0	0.386	1.000	1.000
472	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(3), ATM(14), BRCA1(3), CDKN1A(1), CHEK1(1), CHEK2(7), JUN(1), MAPK8(1), RAD50(2), RAD51(2), RELA(1), TP53(13), TP73(1)	13144815	50	40	47	25	4	3	21	14	8	0	0.917	1.000	1.000
473	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(2), ACTN2(2), ACTN3(1), BCAR1(2), CAPN1(1), CSK(2), FYN(1), ITGA1(4), ITGB1(2), JUN(1), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(1), PPP1R12B(1), PTK2(1), PXN(2), ROCK1(3), SHC1(2), SOS1(4), SRC(1), TLN1(6), VCL(1), ZYX(1)	20766111	44	40	44	18	4	4	14	17	5	0	0.820	1.000	1.000
474	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(1), BID(1), BIRC2(2), BIRC3(2), CASP1(1), CASP10(2), CASP2(2), CASP4(1), CASP7(1), FAS(3), HELLS(3), IKBKB(1), IRF2(1), JUN(1), LTA(1), MAP3K1(3), MAPK10(2), RELA(1), RIPK1(2), TNFRSF1A(2), TP53(13), TP73(1), TRADD(1)	25350655	48	39	48	15	2	6	18	14	8	0	0.375	1.000	1.000
475	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(4), AGMAT(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(1), ARG1(1), CPS1(5), DAO(1), GLUD1(2), GOT1(1), GOT2(3), MAOA(1), MAOB(1), NOS1(7), NOS3(1), OTC(1), P4HA2(1), P4HA3(1), PYCR1(1), SMS(2)	19521954	44	39	44	19	2	1	18	19	4	0	0.827	1.000	1.000
476	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(3), ATM(14), ATR(5), CCNA1(1), CCNE1(1), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(3), DHFR(1), GSK3B(1), HDAC1(1), RB1(2), SKP2(1), TGFB2(1), TP53(13)	13376432	51	39	51	29	6	3	18	15	9	0	0.975	1.000	1.000
477	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(2), ACSS2(3), ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADHFE1(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH7A1(2), ALDH9A1(1), ALDOB(1), DLAT(2), DLD(4), ENO1(1), G6PC(1), GALM(2), GAPDHS(1), GPI(1), LDHAL6B(1), LDHB(1), LDHC(2), PDHA1(1), PDHB(1), PFKL(2), PFKM(1), PGAM1(1), PGK1(2), TPI1(2)	25632894	46	39	46	19	2	3	13	18	10	0	0.857	1.000	1.000
478	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(2), ALAS2(2), COX15(1), EPRS(1), FECH(1), FTMT(1), GUSB(2), HCCS(1), HMOX1(2), MMAB(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2A1(3), UGT2A3(4), UGT2B10(7), UGT2B11(2), UGT2B15(1), UGT2B7(2)	18630103	45	39	43	16	7	3	12	19	4	0	0.549	1.000	1.000
479	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(4), ELK1(1), GNAS(3), GNB1(2), IGF1R(1), ITGB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), MKNK1(1), MKNK2(2), NGFR(1), PDGFRA(6), PPP2CA(1), PTPRR(2), RPS6KA1(2), SHC1(2), SOS1(4), SRC(1), STAT3(1)	14558350	39	38	39	17	3	2	16	18	0	0	0.833	1.000	1.000
480	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(3), ACO1(5), CLYBL(4), CS(2), DLD(4), DLST(2), FH(1), IDH1(2), IDH3B(2), MDH1(2), OGDH(1), OGDHL(2), PC(1), PCK1(2), PCK2(2), SDHA(1), SDHB(1), SDHD(1), SUCLG1(2), SUCLG2(1)	13074638	41	38	41	14	5	1	12	17	6	0	0.651	1.000	1.000
481	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADHFE1(1), AGPAT6(2), AKR1B1(2), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), CEL(1), DGKB(1), DGKG(2), DGKH(4), DGKI(1), DGKQ(1), DGKZ(2), GK(1), GLB1(4), GPAM(1), LCT(1), LIPC(1), LIPF(1), LPL(1), PNLIP(3), PNPLA3(1), PPAP2B(1)	26006909	42	38	42	18	8	1	14	12	7	0	0.759	1.000	1.000
482	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	ABO(1), B3GALT2(2), B3GALT4(1), B3GALT5(1), B3GNT1(1), B3GNT2(2), B3GNT3(1), B3GNT5(1), B4GALT6(1), FUT6(1), GBGT1(2), GCNT2(3), PIGB(1), PIGC(1), PIGG(2), PIGK(1), PIGL(1), PIGM(1), PIGN(2), PIGO(1), PIGP(1), PIGQ(2), PIGT(2), PIGU(1), PIGZ(1), ST3GAL1(1), ST3GAL3(1), ST3GAL5(1), ST6GALNAC5(2), ST8SIA1(1), ST8SIA5(1)	21414365	41	38	41	16	5	1	13	16	6	0	0.764	1.000	1.000
483	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), AKT2(2), AKT3(2), ARHGEF11(2), CDC42(2), DLG4(1), GNA13(2), LPA(2), MAP3K1(3), MAP3K5(4), MAPK8(1), NFKBIL2(2), PDK1(1), PHKA2(1), PIK3CB(2), PLD1(3), PLD3(1), PTK2(1), RDX(1), ROCK1(3), ROCK2(3), TBXA2R(1)	21605664	41	38	41	15	2	4	10	19	6	0	0.649	1.000	1.000
484	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(1), EEF1G(1), EIF2AK1(2), EIF2AK2(3), EIF2B1(2), EIF2B2(1), EIF2B5(2), EIF2S1(1), EIF2S2(1), EIF4A2(3), EIF4E(1), EIF4G1(5), EIF4G3(3), EIF5(2), EIF5A(1), ETF1(1), KIAA0664(2), PABPC1(3), PABPC3(1), PAIP1(2), SLC35A4(1)	19334377	39	38	39	15	2	3	10	20	4	0	0.752	1.000	1.000
485	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(1), GHR(1), INSR(2), IRS1(3), JAK2(5), MAP2K1(1), MAPK1(1), MAPK3(1), PIK3CA(14), PIK3R1(1), PTPN6(1), RPS6KA1(2), SHC1(2), SOS1(4), STAT5A(2)	14530580	41	37	40	17	4	7	11	17	2	0	0.766	1.000	1.000
486	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(1), C1GALT1(1), C1GALT1C1(1), GALNT1(1), GALNT10(2), GALNT11(2), GALNT13(3), GALNT4(1), GALNT5(5), GALNT7(3), GALNT8(3), GALNT9(1), GALNTL2(1), GALNTL5(2), GCNT1(2), GCNT4(1), OGT(3), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(4)	14184405	40	37	40	17	3	1	12	18	6	0	0.896	1.000	1.000
487	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(1), CARS(2), CARS2(3), DARS(2), EPRS(1), FARSA(1), FARSB(1), GARS(1), IARS(2), IARS2(2), LARS(1), MARS(2), NARS2(4), PARS2(2), QARS(1), RARS2(1), SARS(1), TARS(1), TARS2(2), VARS(2), VARS2(3), WARS2(2), YARS(1)	23879668	40	37	40	13	1	1	14	17	7	0	0.616	1.000	1.000
488	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BCL2A1(2), CASP1(1), CASP10(2), CASP2(2), CASP4(1), CASP7(1), DAXX(4), FAS(3), IKBKE(1), LTA(1), NGFR(1), NTRK1(2), PTPN13(7), RIPK1(2), SFRS2IP(6), TNFRSF1A(2), TRADD(1)	19399869	40	36	40	13	2	2	12	20	4	0	0.579	1.000	1.000
489	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F11(1), F12(1), F13B(2), F2(2), F5(5), F8(4), FGA(2), FGB(1), FGG(2), LPA(2), PLAT(1), PLAU(4), PLG(1), SERPINF2(2), VWF(6)	15514026	36	36	36	16	5	2	10	14	5	0	0.761	1.000	1.000
490	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(1), APC(6), AXIN1(1), CTNNB1(2), DVL1(1), FZD1(2), GNAI1(2), GSK3B(1), IRAK1(3), LEF1(1), PIK3CA(14), PIK3R1(1), PPP2CA(1), RELA(1), TLR4(1)	13537516	38	36	37	19	1	4	13	15	5	0	0.859	1.000	1.000
491	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(6), AR(1), ESR2(1), ESRRA(1), NPM1(1), NR1H2(2), NR1H3(1), NR1I2(2), NR1I3(1), NR2F2(1), NR4A1(1), NR4A2(1), NR5A2(2), PGR(2), PPARG(1), RARA(4), RARB(1), ROR1(1), RORA(2), RXRB(3), RXRG(1), THRA(3), VDR(1)	18480544	40	36	39	18	5	5	6	13	11	0	0.956	1.000	1.000
492	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	JAK2(5), JUN(1), MAP2K1(1), MAPK3(1), MPL(1), PIK3CA(14), PIK3R1(1), RASA1(2), SHC1(2), SOS1(4), STAT1(2), STAT3(1), STAT5A(2)	13170312	37	36	36	16	3	5	12	15	2	0	0.823	1.000	1.000
493	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(6), ATF2(1), AXIN1(1), BMP5(2), BMP7(1), BMPR2(4), CHRD(2), CTNNB1(2), DVL1(1), FZD1(2), GATA4(1), GSK3B(1), MAP3K7(2), MEF2C(2), MYL2(1), NPPA(1), NPPB(1), RFC1(2), TGFB2(1), TGFBR2(1), TGFBR3(1)	16042319	36	35	36	19	1	3	10	17	5	0	0.936	1.000	1.000
494	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(1), APAF1(1), ATM(14), BID(1), CASP7(1), EIF2S1(1), PTK2(1), PXN(2), STAT1(2), TLN1(6), TP53(13)	12088534	43	35	43	16	3	3	17	13	7	0	0.586	1.000	1.000
495	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(2), CASP7(1), CFLAR(1), DAXX(4), FAF1(1), JUN(1), LMNA(1), MAP3K1(3), MAP3K7(2), MAPK8(1), PAK1(1), PAK2(2), PRKDC(5), PTPN13(7), RB1(2), RIPK2(1), SPTAN1(3)	18427284	39	35	39	18	3	2	12	13	9	0	0.874	1.000	1.000
496	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(4), AGXT(1), ALAS1(2), ALAS2(2), AMT(1), AOC2(1), AOC3(1), BHMT(2), CHKB(1), CTH(1), DAO(1), DLD(4), DMGDH(2), GARS(1), MAOA(1), MAOB(1), PISD(1), PLCB2(1), PLCG2(2), SARDH(2), SARS(1), SHMT1(2), SHMT2(2), TARS(1)	18588201	38	35	38	12	3	3	13	15	4	0	0.523	1.000	1.000
497	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(4), EP300(6), FYN(1), IL7R(1), JAK1(4), JAK3(2), PIK3CA(14), PIK3R1(1), PTK2B(2), STAT5A(2)	12343986	37	35	36	13	1	4	16	13	3	0	0.549	1.000	1.000
498	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(14), ATR(5), CDC25C(2), CHEK1(1), CHEK2(7), TP53(13)	7058116	42	35	39	21	4	2	17	10	9	0	0.917	1.000	1.000
499	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), AKT2(2), AKT3(2), ANKRD6(1), APC(6), AXIN1(1), AXIN2(1), CSNK1A1(1), CTNNB1(2), DACT1(1), DKK1(1), DVL1(1), FSTL1(1), GSK3A(1), GSK3B(1), LRP1(6), MVP(3), NKD1(2), NKD2(1), SFRP1(2)	17829422	37	35	36	21	3	2	14	12	6	0	0.967	1.000	1.000
500	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACADM(1), ACADS(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), AOX1(4), BCKDHA(1), ECHS1(1), EHHADH(2), HADHA(1), HADHB(1), HIBADH(1), IVD(1), MCCC1(2), MCCC2(4), MCEE(1), MUT(2), OXCT1(1), PCCA(2), PCCB(2)	15822732	35	35	34	13	5	1	12	13	4	0	0.591	1.000	1.000
501	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(1), JAK2(5), JUN(1), MAP2K1(1), MAP3K1(3), MAPK3(1), MAPK8(1), PIK3CA(14), PIK3R1(1), SOS1(4), STAT1(2), STAT5A(2)	12334012	36	34	35	14	1	5	12	13	5	0	0.677	1.000	1.000
502	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(1), APC(6), DLG4(1), EPHB2(1), GNAI1(2), ITPR1(2), ITPR2(7), ITPR3(1), KCNJ3(3), MAPK1(1), PITX2(2), RYR1(12)	20291857	39	34	39	20	8	5	9	13	4	0	0.901	1.000	1.000
503	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(1), ATF2(1), CALM1(2), CALM2(1), EGFR(4), ELK1(1), JUN(1), MAP2K1(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(1), MEF2A(2), MEF2C(2), MEF2D(1), PAK1(1), PTK2(1), PTK2B(2), SHC1(2), SOS1(4), SRC(1), SYT1(1)	14786351	36	33	36	13	4	3	16	9	4	0	0.573	1.000	1.000
504	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH1B(1), ADH1C(1), ADHFE1(1), AKR1B1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), CEL(1), DGKB(1), DGKG(2), DGKH(4), DGKQ(1), DGKZ(2), GK(1), GLB1(4), LCT(1), LIPC(1), LIPF(1), LPL(1), PNLIP(3), PPAP2B(1)	21381155	36	33	36	14	6	1	13	11	5	0	0.675	1.000	1.000
505	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX15B(2), ALOX5(1), CBR1(2), CYP2B6(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(2), CYP2J2(1), CYP4A11(4), CYP4F2(1), DHRS4(2), EPHX2(1), GGT1(1), GPX3(1), GPX4(1), GPX6(1), LTA4H(3), PLA2G12A(1), PLA2G4A(1), PLA2G6(1), PTGDS(1), PTGES(1), PTGS2(4), TBXAS1(1)	17144945	37	33	37	17	4	5	9	14	5	0	0.888	1.000	1.000
506	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(1), ARHGAP5(3), ARHGAP6(1), ARHGEF1(1), ARHGEF11(2), ARHGEF5(2), ARPC2(1), ARPC3(1), GSN(1), LIMK1(2), MYL2(1), MYLK(3), OPHN1(1), PPP1R12B(1), ROCK1(3), SRC(1), TLN1(6), VCL(1)	20117723	34	33	34	13	1	2	9	19	3	0	0.764	1.000	1.000
507	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(1), BID(1), BIRC2(2), BIRC3(2), CASP2(2), CASP7(1), FAS(3), JUN(1), MAP3K1(3), MAP3K14(1), MAPK10(2), PARP1(2), RELA(1), RIPK1(2), TNFRSF1A(2), TP53(13), TRADD(1)	16502814	40	32	40	14	2	5	15	12	6	0	0.499	1.000	1.000
508	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), CALM1(2), CALM2(1), ELK1(1), JUN(1), LYN(1), MAP2K1(1), MAP3K1(3), MAPK14(1), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), PPP3CB(1), PPP3CC(2), SHC1(2), SOS1(4), SYK(1), SYT1(1), VAV1(2)	16805232	36	32	36	18	6	2	12	10	6	0	0.901	1.000	1.000
509	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(1), AKT1(1), GNAI1(2), GNB1(2), MAPK1(1), MAPK3(1), PDGFA(1), PDGFRA(6), PIK3CA(14), PIK3R1(1), PLCB1(1), PTK2(1), SMPD1(1), SRC(1)	12069374	34	32	33	17	1	3	11	16	3	0	0.930	1.000	1.000
510	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(2), ITGB1(2), KLRC1(2), KLRC2(2), KLRC3(1), KLRD1(1), MAP2K1(1), MAPK3(1), PAK1(1), PIK3CA(14), PIK3R1(1), PTK2B(2), PTPN6(1), SYK(1), VAV1(2)	8184482	34	32	32	11	3	4	13	11	3	0	0.460	1.000	1.000
511	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(14), BMPR1B(1), CCND2(1), CDK4(1), EGR1(1), ESR2(1), LHCGR(1), NCOR1(6), NRIP1(3), PGR(2), PRLR(2), PTGER2(1), SMPD1(1), VDR(1), ZP2(1)	15425058	37	32	37	15	3	0	15	11	8	0	0.695	1.000	1.000
512	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(7), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1), LDHB(1), LDHC(2), MCEE(1), MLYCD(1), MUT(2), PCCA(2), PCCB(2), SUCLG1(2), SUCLG2(1)	14523472	33	32	33	14	3	4	14	8	4	0	0.661	1.000	1.000
513	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(3), CREBBP(4), EP300(6), ERCC3(1), GRIP1(1), GTF2A1(1), GTF2F1(1), HDAC1(1), HDAC4(1), HDAC6(2), MEF2C(2), NCOR2(3), NRIP1(3), POLR2A(5), SRA1(1)	20365024	35	31	35	28	0	4	15	13	3	0	0.998	1.000	1.000
514	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(3), ALDOB(1), FPGT(3), FUK(1), GMDS(1), GMPPB(2), KHK(3), MTMR1(3), MTMR2(1), MTMR6(2), PFKFB2(1), PFKFB3(1), PFKL(2), PFKM(1), PGM2(1), RDH11(2), TPI1(2)	16515649	32	31	32	18	2	4	11	9	6	0	0.943	1.000	1.000
515	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ARG1(1), ASS1(1), CPS1(5), DAO(1), EPRS(1), GLUD1(2), GOT1(1), GOT2(3), LAP3(2), NOS1(7), NOS3(1), OTC(1), P4HA2(1), P4HA3(1), PARS2(2), PYCR1(1), PYCR2(1), RARS2(1)	15821959	33	31	33	18	2	0	13	15	3	0	0.956	1.000	1.000
516	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(4), ADCY3(1), ADCY9(3), ARF1(1), ARF5(1), ARF6(1), ATP6V0A1(3), ATP6V0A4(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1C1(2), ERO1L(1), GNAS(3), PLCG2(2), SEC61A2(1), SEC61B(1), SEC61G(1), TRIM23(3)	16250849	33	31	33	17	3	2	10	17	1	0	0.946	1.000	1.000
517	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	ELK1(1), IGF1(1), IGF1R(1), IRS1(3), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(1), PIK3CA(14), PIK3R1(1), PTPN11(1), RASA1(2), SHC1(2), SOS1(4)	10880709	34	31	33	16	3	3	15	12	1	0	0.806	1.000	1.000
518	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(1), ARHGEF1(1), F2(2), GNA13(2), GNAI1(2), GNB1(2), MAP3K7(2), PIK3CA(14), PIK3R1(1), PLCB1(1), PPP1R12B(1), PTK2B(2), ROCK1(3)	11405477	34	31	33	12	1	2	12	14	5	0	0.592	1.000	1.000
519	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(3), CDKN2A(3), PIK3CA(14), PIK3R1(1), POLR1A(1), POLR1B(2), RB1(2), TP53(13)	8973004	39	30	38	20	4	4	17	12	2	0	0.860	1.000	1.000
520	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), DLAT(2), DLD(4), ENO1(1), G6PC(1), GAPDHS(1), GOT1(1), GOT2(3), GPI(1), LDHAL6B(1), LDHB(1), LDHC(2), MDH1(2), PC(1), PCK1(2), PDHA1(1), PDHB(1), PDHX(1), PFKL(2), PFKM(1), PGAM1(1), PGK1(2), TPI1(2)	18679836	35	30	35	17	2	2	11	13	7	0	0.909	1.000	1.000
521	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(1), CALM1(2), CALM2(1), ELK1(1), GNAI1(2), GNAS(3), GNB1(2), JUN(1), MAP2K1(1), MAPK3(1), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), SYT1(1)	15353941	33	30	33	15	6	1	9	14	3	0	0.884	1.000	1.000
522	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	ELK1(1), INSR(2), IRS1(3), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(1), PIK3CA(14), PIK3R1(1), PTPN11(1), RASA1(2), SHC1(2), SOS1(4)	11202370	34	30	33	13	3	4	14	12	1	0	0.583	1.000	1.000
523	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(6), AXIN1(1), CREBBP(4), CTNNB1(2), DVL1(1), EP300(6), FZD1(2), GSK3B(1), HDAC1(1), LEF1(1), PITX2(2), TRRAP(6)	14585886	33	30	33	19	1	3	12	15	2	0	0.942	1.000	1.000
524	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(2), JUN(1), LMNA(1), MADD(2), MAP3K1(3), MAP3K7(2), MAPK8(1), PAK1(1), PAK2(2), PRKDC(5), RB1(2), RIPK1(2), SPTAN1(3), TNFRSF1A(2), TRADD(1)	17386573	32	30	32	17	2	3	13	7	7	0	0.889	1.000	1.000
525	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(2), CXCR4(1), GNAI1(2), GNB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), PIK3C2G(1), PIK3CA(14), PIK3R1(1), PTK2(1), PTK2B(2), PXN(2), RELA(1)	12269241	32	29	31	15	1	4	12	12	3	0	0.850	1.000	1.000
526	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(1), ADH1C(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOB(1), DLAT(2), DLD(4), ENO1(1), G6PC(1), GPI(1), LDHB(1), LDHC(2), PDHA1(1), PDHB(1), PFKM(1), PGAM1(1), PGK1(2), TPI1(2)	21484939	34	29	34	19	1	2	10	15	6	0	0.982	1.000	1.000
527	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(1), ADH1C(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOB(1), DLAT(2), DLD(4), ENO1(1), G6PC(1), GPI(1), LDHB(1), LDHC(2), PDHA1(1), PDHB(1), PFKM(1), PGAM1(1), PGK1(2), TPI1(2)	21484939	34	29	34	19	1	2	10	15	6	0	0.982	1.000	1.000
528	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(1), AKT1(1), CSF2RB(1), IGF1(1), IGF1R(1), IL3(1), IL3RA(1), KITLG(2), PIK3CA(14), PIK3R1(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2)	9624143	30	28	29	12	3	2	11	13	1	0	0.645	1.000	1.000
529	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(1), AKT1(1), CALM1(2), CALM2(1), GNAS(3), GNB1(2), NOS3(1), NPPA(1), PIK3CA(14), PIK3R1(1), RELA(1), SYT1(1)	7869145	29	28	28	10	1	2	11	14	1	0	0.669	1.000	1.000
530	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(4), ACY1(1), AGMAT(2), ALDH18A1(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(1), ARG1(1), ASS1(1), CPS1(5), MAOA(1), MAOB(1), OTC(1), SAT1(1), SMS(2)	13025380	30	28	30	14	1	1	13	11	4	0	0.863	1.000	1.000
531	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10(1), ALG10B(2), ALG13(3), ALG2(1), ALG5(1), ALG8(2), DDOST(1), DOLPP1(1), DPAGT1(2), GANAB(1), MAN2A1(2), MGAT3(1), MGAT4A(3), MGAT5(3), MGAT5B(1), RFT1(1), RPN1(1), RPN2(2), STT3B(2)	18735926	31	28	31	13	3	1	8	18	1	0	0.814	1.000	1.000
532	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	CS(2), DLAT(2), DLD(4), DLST(2), FH(1), IDH3B(2), MDH1(2), OGDH(1), PC(1), PDHA1(1), PDHB(1), PDHX(1), PDK1(1), PDK2(1), PDK3(1), PDP2(1), SDHA(1), SDHB(1), SDHD(1), SUCLG1(2), SUCLG2(1)	12466556	30	28	30	12	1	0	11	13	5	0	0.799	1.000	1.000
533	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(4), DAXX(4), PML(1), RARA(4), RB1(2), SIRT1(2), SP100(1), TNFRSF1A(2), TP53(13)	8469884	33	28	33	17	3	3	15	10	2	0	0.862	1.000	1.000
534	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(1), ERCC3(1), GTF2A2(1), GTF2E2(2), GTF2F2(1), GTF2H1(1), POLR1A(1), POLR1B(2), POLR2A(5), POLR2B(4), POLR2F(1), POLR2I(1), POLR3B(4), POLR3E(1), POLR3H(1), TAF5(2), TAF9(1)	15387357	30	28	28	20	2	3	10	11	4	0	0.987	1.000	1.000
535	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BLNK(2), ELK1(1), JUN(1), LYN(1), MAP2K1(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8IP3(1), PAPPA(1), RPS6KA1(2), SHC1(2), SOS1(4), SYK(1), VAV1(2), VAV2(3), VAV3(2)	14146516	30	28	30	10	4	3	9	9	5	0	0.461	1.000	1.000
536	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ABP1(4), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), AOC2(1), AOC3(1), CNDP1(3), DPYD(1), DPYS(1), ECHS1(1), EHHADH(2), GAD1(1), HADHA(1), MLYCD(1), SMS(2), UPB1(1)	12788579	28	27	28	14	4	2	11	9	2	0	0.833	1.000	1.000
537	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ABP1(4), ACADM(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), AOC2(1), AOC3(1), CNDP1(3), DPYD(1), DPYS(1), ECHS1(1), EHHADH(2), GAD1(1), HADHA(1), MLYCD(1), SMS(2), UPB1(1)	11901083	28	27	28	12	4	2	10	8	4	0	0.687	1.000	1.000
538	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(1), IGF1R(1), IRS1(3), MAP2K1(1), MAPK1(1), MAPK3(1), PIK3CA(14), PIK3R1(1), SHC1(2), SOS1(4)	8299856	29	27	28	10	3	4	10	11	1	0	0.523	1.000	1.000
539	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(1), EGFR(4), IGF1R(1), POLR2A(5), PPP2CA(1), RB1(2), TEP1(1), TERT(3), TNKS(2), TP53(13), XRCC5(2)	12428925	35	27	35	22	3	3	20	6	3	0	0.934	1.000	1.000
540	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPS(1), CDS2(1), CHAT(2), CHKB(1), CLC(1), DGKB(1), DGKG(2), DGKH(4), DGKQ(1), DGKZ(2), ETNK1(1), GNPAT(2), LYPLA1(1), PAFAH1B1(1), PAFAH2(2), PCYT1B(1), PISD(1), PLA2G4A(1), PLA2G6(1), PLCB2(1), PLCG2(2), PPAP2B(1)	22161028	31	26	31	15	6	3	9	11	2	0	0.811	1.000	1.000
541	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(1), ATM(14), CCNE1(1), CDK2(1), CDK4(1), CDKN1A(1), PCNA(2), RB1(2), TP53(13)	8015715	36	26	36	18	3	2	15	8	8	0	0.863	1.000	1.000
542	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(14), CDC25A(1), CDC25C(2), CDK2(1), CDK4(1), CHEK1(1), RB1(2), TP53(13)	7763036	35	26	35	22	3	2	13	8	9	0	0.979	1.000	1.000
543	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(6), CDH1(3), CREBBP(4), EP300(6), MAP2K1(1), MAP3K7(2), MAPK3(1), SKIL(1), TGFB2(1), TGFBR2(1)	11247652	26	26	26	14	2	3	12	7	2	0	0.813	1.000	1.000
544	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(2), CSF1R(2), EGF(3), EGFR(4), MET(5), PDGFRA(6), SH3GLB1(1), SH3GLB2(1), SRC(1)	8519214	25	25	25	10	0	0	10	12	3	0	0.828	1.000	1.000
545	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(1), MAP2K1(1), MAP2K3(2), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), PIK3CA(14), PIK3R1(1), RB1(2), RELA(1), SP1(1)	8553846	29	25	28	10	2	4	10	8	5	0	0.464	1.000	1.000
546	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(1), ABAT(1), ADSL(1), AGXT(1), ASS1(1), CAD(2), CRAT(1), DARS(2), DLAT(2), DLD(4), GAD1(1), GOT1(1), GOT2(3), GPT2(1), NARS2(4), PC(1), PDHA1(1), PDHB(1)	16640716	30	25	30	15	4	1	6	11	8	0	0.939	1.000	1.000
547	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(1), CCNE1(1), CDK2(1), CDK4(1), CDKN1A(1), MAPK1(1), MAPK3(1), PAK1(1), PIK3CA(14), PIK3R1(1), RB1(2), RELA(1)	8904595	26	25	25	11	2	3	11	8	2	0	0.689	1.000	1.000
548	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), CAD(2), CPS1(5), EPRS(1), GAD1(1), GFPT2(2), GLS(1), GLS2(1), GLUD1(2), GOT1(1), GOT2(3), GPT2(1), GSR(1), GSS(1), NAGK(2), QARS(1)	17404044	26	24	26	11	4	0	13	7	2	0	0.647	1.000	1.000
549	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(1), ADRB2(1), CHRM2(3), CHRM3(2), CHRM5(1), DRD1(1), DRD2(1), DRD3(1), DRD5(3), HTR1A(2), HTR1E(3), HTR2A(2), HTR2C(1), HTR5A(1), HTR7(1)	11257262	24	24	24	11	5	3	2	13	1	0	0.864	1.000	1.000
550	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(2), ACTN2(2), ACTN3(1), CAPN1(1), ITGA1(4), ITGB1(2), PTK2(1), PXN(2), SPTAN1(3), SRC(1), TLN1(6)	12524557	25	24	25	10	2	2	8	9	4	0	0.852	1.000	1.000
551	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(3), G6PC(1), GAA(2), GALE(1), GALK2(2), GALT(2), GANC(1), GLB1(4), LCT(1), PFKL(2), PFKM(1), RDH11(2)	17113423	24	23	24	12	2	2	6	11	3	0	0.915	1.000	1.000
552	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	ELK1(1), IL2RA(2), IL2RB(1), JAK1(4), JAK3(2), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(1), SHC1(2), SOS1(4), STAT5A(2), SYK(1)	10346138	23	23	23	12	4	2	7	7	3	0	0.902	1.000	1.000
553	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(1), CAT(2), GH1(1), GHR(1), IGF1(1), IGF1R(1), PIK3CA(14), PIK3R1(1), SHC1(2), SOD2(1)	5820422	25	23	24	11	1	2	10	11	1	0	0.775	1.000	1.000
554	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(2), CALM1(2), CALM2(1), JUN(1), MAP2K1(1), MAP2K3(2), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(1), PAK1(1), PTK2B(2), SHC1(2), SOS1(4), SRC(1), SYT1(1)	12515899	27	23	27	14	4	2	9	8	4	0	0.910	1.000	1.000
555	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	IFNGR1(1), IKBKB(1), JAK2(5), RB1(2), RELA(1), TNFRSF1A(2), TP53(13), USH1C(1), WT1(3)	8118921	29	23	29	16	2	3	13	7	4	0	0.897	1.000	1.000
556	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(6), AXIN1(1), CREBBP(4), CSNK1A1(1), CTBP1(1), CTNNB1(2), DVL1(1), FZD1(2), GSK3B(1), HDAC1(1), MAP3K7(2), PPP2CA(1), TLE1(2)	12986296	25	23	25	16	1	2	10	9	3	0	0.954	1.000	1.000
557	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), ARSB(3), ARSE(1), CYP11B2(2), HSD17B8(1), HSD3B1(1), SRD5A1(1), STS(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2B15(1)	12067228	24	22	24	10	1	4	7	8	4	0	0.662	1.000	1.000
558	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSE(1), B4GALT6(1), DEGS1(3), ENPP7(2), GAL3ST1(2), GALC(1), GBA(1), GLB1(4), LCT(1), NEU1(1), NEU3(1), PPAP2B(1), SGPP1(1), SGPP2(2), SMPD1(1), SPHK2(1)	15841416	24	22	24	10	2	0	6	11	5	0	0.805	1.000	1.000
559	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	DLG4(1), EPHB2(1), F2(2), F2RL2(1), JUN(1), MAPK1(1), MAPK7(1), MAPK8(1), PLD1(3), PLD3(1), PTK2(1), RASAL1(2), SRC(1), TEC(3), VAV1(2)	12088879	22	22	22	11	5	2	4	10	1	0	0.918	1.000	1.000
560	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), ATF1(1), CDC42(2), DUSP10(1), EIF4E(1), ELK1(1), MAP2K3(2), MAP3K10(2), MAP3K4(6), MAP3K5(4), MAP3K7(2), MAPK1(1), MAPK12(1), MAPK13(1), MAPK14(1), MKNK1(1), MKNK2(2)	14673799	30	22	30	12	2	2	8	15	3	0	0.781	1.000	1.000
561	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN2(2), ACTN3(1), BCAR1(2), CSK(2), CTNNA1(4), CTNNA2(3), CTNNB1(2), PTK2(1), PXN(2), SRC(1), VCL(1)	8408858	23	21	23	13	3	0	8	8	4	0	0.962	1.000	1.000
562	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), ALOX5(1), CYP1A2(2), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(2), CYP2J2(1), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(1), RDH11(2)	10519362	21	21	21	10	3	2	7	8	1	0	0.801	1.000	1.000
563	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BRAF(5), DUSP9(1), EIF4E(1), MAP2K1(1), MAPK1(1), MAPK3(1), MKNK1(1), MKNK2(2), RPS6KA1(2), RPS6KA2(1), SHC1(2), SOS1(4), SOS2(1)	13025622	24	21	24	13	3	3	6	8	4	0	0.947	1.000	1.000
564	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(6), EPHB2(1), ITPKA(1), ITPKB(2), JUN(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK8(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1)	12574915	21	21	21	21	4	3	6	6	2	0	0.998	1.000	1.000
565	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), PGAP1(2), PIGB(1), PIGC(1), PIGG(2), PIGK(1), PIGL(1), PIGM(1), PIGN(2), PIGO(1), PIGP(1), PIGQ(2), PIGT(2), PIGU(1), PIGZ(1)	10594615	20	20	20	10	2	2	5	9	2	0	0.896	1.000	1.000
566	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2A1(1), GTF2F1(1), NCOA1(2), NCOA2(2), NCOA3(4), NCOR2(3), POLR2A(5), RARA(4)	11001556	23	20	23	19	0	3	8	8	4	0	0.994	1.000	1.000
567	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(3), PRB1(4), TP53(13)	3754793	24	20	23	11	3	2	9	6	4	0	0.709	1.000	1.000
568	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	GNAS(3), GNB1(2), LIMK1(2), MAP2K1(1), MAPK1(1), MAPK3(1), MYL2(1), NOX1(2), PIK3C2G(1), PLCB1(1), PPP1R12B(1), PTK2(1), ROCK2(3)	11193652	20	19	20	12	1	3	4	11	1	0	0.977	1.000	1.000
569	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), GNAI1(2), GNB1(2), ITGA1(4), ITGB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), PLA2G4A(1), PLCB1(1), PTK2(1), SRC(1), SYK(1), TBXAS1(1)	10706616	21	19	21	14	2	4	6	5	4	0	0.976	1.000	1.000
570	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	JAK1(4), JAK2(5), JAK3(2), STAT1(2), STAT3(1), STAT5A(2), TYK2(3)	8147330	19	18	19	11	1	2	5	8	3	0	0.965	1.000	1.000
571	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	EPRS(1), FECH(1), GUSB(2), HCCS(1), HMOX1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2B15(1)	12041487	20	18	20	10	3	3	4	8	2	0	0.840	1.000	1.000
572	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(2), DARS(2), EPRS(1), GARS(1), IARS(2), LARS(1), MARS(2), QARS(1), SARS(1), TARS(1), WARS2(2), YARS(1)	14080637	18	17	18	10	0	1	6	8	3	0	0.949	1.000	1.000
573	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(1), G6PD(1), GPI(1), H6PD(2), PFKL(2), PFKM(1), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(1), TALDO1(1), TKTL1(1), TKTL2(2)	10731947	17	17	17	11	1	0	8	7	1	0	0.949	1.000	1.000
574	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT6(2), AGPS(1), CHPT1(1), ENPP2(3), PAFAH1B1(1), PAFAH1B2(1), PAFAH2(2), PLA2G12A(1), PLA2G4A(1), PLA2G6(1), PLD1(3), PPAP2B(1)	10229782	18	17	18	8	1	1	7	9	0	0	0.782	1.000	1.000
575	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), CA12(1), CA14(2), CA5B(1), CA7(1), CA9(1), CPS1(5), CTH(1), GLS(1), GLS2(1), GLUD1(2)	9356419	17	17	17	9	1	1	8	7	0	0	0.834	1.000	1.000
576	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), CA12(1), CA14(2), CA5B(1), CA7(1), CA9(1), CPS1(5), CTH(1), GLS(1), GLS2(1), GLUD1(2)	8362467	17	17	17	7	1	1	8	7	0	0	0.665	1.000	1.000
577	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(6), AXIN1(1), CTNNB1(2), DVL1(1), FZD1(2), GSK3B(1), NOTCH1(4)	9443310	17	17	17	14	1	2	6	5	3	0	0.987	1.000	1.000
578	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOB(1), FPGT(3), GMDS(1), GMPPB(2), KHK(3), PFKFB3(1), PFKM(1), TPI1(2)	10595715	16	16	16	15	0	3	6	4	3	0	0.998	1.000	1.000
579	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), G6PC(1), GAA(2), GALE(1), GALK2(2), GALT(2), GANAB(1), GLB1(4), LCT(1), PFKM(1)	14411295	17	16	17	11	0	1	4	9	3	0	0.983	1.000	1.000
580	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(14), CDC25A(1), CDC25C(2), CHEK1(1)	6049255	18	15	18	12	0	0	4	7	7	0	0.982	1.000	1.000
581	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(1), CASP1(1), CASP7(1), INSR(2), MAGI1(1), MAGI2(5), RERE(2), WWP1(1), WWP2(1)	10572880	15	15	15	13	3	2	2	5	3	0	0.996	1.000	1.000
582	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(1), ADRB2(1), CFTR(4), GNAS(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2)	5728492	15	14	15	6	2	0	4	9	0	0	0.830	1.000	1.000
583	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(1), F2(2), FGA(2), FGB(1), FGG(2), PLAT(1), PLAU(4), PLG(1)	5892597	14	14	14	10	2	1	3	6	2	0	0.972	1.000	1.000
584	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(3), G6PD(1), GGT1(1), GPX3(1), GPX4(1), GPX6(1), GSR(1), GSS(1), GSTA3(1), IDH1(2), TXNDC12(1)	9590325	14	14	14	10	0	0	4	7	3	0	0.987	1.000	1.000
585	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(5), HMGCR(1), LIPC(1), LPL(1), LRP1(6)	12021814	14	14	14	10	2	0	3	8	1	0	0.987	1.000	1.000
586	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(1), CCND2(1), CCNE1(1), CCNH(1), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(3), CDKN2C(1), RB1(2)	7150139	14	13	14	12	1	0	4	7	2	0	0.992	1.000	1.000
587	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	JUN(1), KEAP1(3), MAPK1(1), MAPK14(1), MAPK8(1), NFE2L2(5)	3908466	12	12	12	5	0	1	5	6	0	0	0.746	1.000	1.000
588	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(1), CREM(1), FHL5(2), GNAS(3), XPO1(5)	4181801	12	12	12	5	2	0	5	5	0	0	0.779	1.000	1.000
589	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	COASY(2), DPYD(1), DPYS(1), ENPP3(2), ILVBL(1), PANK1(1), PANK2(2), PANK3(1), UPB1(1), VNN1(1)	7610921	13	12	13	11	1	0	3	6	3	0	0.985	1.000	1.000
590	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(1), G6PD(1), GPI(1), H6PD(2), PFKM(1), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(1), TALDO1(1)	8999659	12	12	12	10	0	0	6	5	1	0	0.984	1.000	1.000
591	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(1), FYN(1), LRP8(1), RELN(5), VLDLR(4)	6162508	12	12	12	6	1	0	5	6	0	0	0.861	1.000	1.000
592	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(3), GNB1(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2)	4200655	11	11	11	5	2	0	2	7	0	0	0.869	1.000	1.000
593	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(7), NRG2(2), NRG3(2)	3959285	11	11	11	5	1	1	4	5	0	0	0.740	1.000	1.000
594	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(3), G6PD(1), GGT1(1), GPX3(1), GPX4(1), GSS(1), GSTA3(1), IDH1(2)	7937520	11	11	11	11	0	0	2	7	2	0	0.999	1.000	1.000
595	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDK2(1), CUL1(3), FBXW7(4), RB1(2)	3689521	11	10	11	10	0	1	5	3	2	0	0.989	1.000	1.000
596	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	KHK(3), LCT(1), PYGL(1), PYGM(2), TPI1(2), TREH(1)	5892890	10	10	10	5	1	2	5	2	0	0	0.781	1.000	1.000
597	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(2), CALM2(1), CCL2(1), CXCR4(1), JUN(1), MAPK14(1), MAPK8(1), PTK2B(2), SYT1(1)	6038254	11	9	11	6	1	0	6	4	0	0	0.848	1.000	1.000
598	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	GOSR1(1), SEC22B(1), SNAP25(1), STX19(1), STX2(1), STX7(1), STX8(1), TSNARE1(2)	7408198	9	9	9	6	1	0	4	4	0	0	0.921	1.000	1.000
599	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(1), GNAS(3), GNB1(2), PRKACA(1), PRKAR1A(1)	2876369	8	8	8	5	0	0	2	6	0	0	0.954	1.000	1.000
600	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX3(3), FADS2(2), PLA2G12A(1), PLA2G4A(1), PLA2G6(1)	4484190	8	8	8	5	2	3	1	2	0	0	0.861	1.000	1.000
601	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(2), ADORA3(1), LTB4R(1), P2RY2(1), P2RY6(1)	2608883	6	6	6	4	0	1	2	3	0	0	0.882	1.000	1.000
602	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(4), GZMA(1), HMGB2(1)	4667730	6	6	6	4	0	0	4	2	0	0	0.857	1.000	1.000
603	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(1), CDC25C(2), CSK(2), SRC(1)	4035181	6	6	6	6	0	0	2	4	0	0	0.984	1.000	1.000
604	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(5), MAPK1(1), SRC(1)	5020499	7	6	7	13	0	2	4	0	1	0	1.000	1.000	1.000
605	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(1), ACADS(2), ECHS1(1), HADHA(1)	2375738	5	5	4	4	3	0	2	0	0	0	0.801	1.000	1.000
606	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(3), SNCAIP(1), UBE2E2(1)	2811271	5	5	5	5	2	0	3	0	0	0	0.937	1.000	1.000
607	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), SREBF1(1), SREBF2(2)	5259103	4	4	4	3	1	0	2	1	0	0	0.883	1.000	1.000
608	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), NR1H3(1), NR1H4(1)	2403800	3	3	3	5	0	0	1	2	0	0	0.998	1.000	1.000
609	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PTK2B(2)	2944597	3	3	3	4	0	0	2	1	0	0	0.977	1.000	1.000
610	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	IMPA2(1), TGDS(1)	5142863	2	2	2	5	0	0	1	1	0	0	0.998	1.000	1.000
611	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), LPL(1)	2339968	2	2	2	2	0	0	1	1	0	0	0.948	1.000	1.000
612	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(1), PPARG(1)	2549168	2	2	2	6	1	0	1	0	0	0	0.999	1.000	1.000
613	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(1)	2180368	1	1	1	3	1	0	0	0	0	0	0.993	1.000	1.000
614	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	TGDS(1)	4509713	1	1	1	4	0	0	1	0	0	0	0.997	1.000	1.000
615	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		222094	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		670538	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
