Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.075 0.135 -9999.0 0.0 -0.243 9.0 9.0 epithelial cell differentiation -0.051 0.14 -9999.0 0.0 -0.229 9.0 9.0 CYFIP2 0.031 0.033 -9999.0 0.0 -0.139 1.0 1.0 ENAH -0.066 0.084 -9999.0 0.0 -0.387 1.0 1.0 EGFR -0.007 0.117 -9999.0 0.0 -0.314 3.0 3.0 EPHA2 0.023 0.035 -9999.0 0.0 -0.139 1.0 1.0 MYO6 -0.077 0.141 0.183 1.0 -0.242 9.0 10.0 CTNNB1 0.004 0.115 -9999.0 0.0 -0.401 2.0 2.0 ABI1/Sra1/Nap1 0.06 0.038 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.059 0.109 -9999.0 0.0 -0.378 1.0 1.0 CTNND1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.058 0.109 0.182 1.0 -0.201 9.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.069 0.117 0.182 1.0 -0.217 9.0 10.0 EGF 0.023 0.046 -9999.0 0.0 -0.139 2.0 2.0 NCKAP1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.059 0.109 -9999.0 0.0 -0.378 1.0 1.0 cortical microtubule organization -0.051 0.14 -9999.0 0.0 -0.229 9.0 9.0 GO:0000145 -0.069 0.095 0.165 1.0 -0.192 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.048 0.145 -9999.0 0.0 -0.231 9.0 9.0 MLLT4 0.019 0.083 -9999.0 0.0 -0.401 1.0 1.0 ARF6/GDP -0.087 0.092 -9999.0 0.0 -0.303 2.0 2.0 ARF6 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.063 0.055 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.077 0.116 -9999.0 0.0 -0.285 5.0 5.0 PVRL2 0.009 0.082 -9999.0 0.0 -0.401 1.0 1.0 ZYX -0.056 0.12 0.183 1.0 -0.225 8.0 9.0 ARF6/GTP 0.077 0.046 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.132 0.188 -9999.0 0.0 -0.289 14.0 14.0 EGFR/EGFR/EGF/EGF -0.077 0.131 -9999.0 0.0 -0.222 11.0 11.0 RhoA/GDP -0.052 0.156 -9999.0 0.0 -0.24 9.0 9.0 actin cytoskeleton organization -0.088 0.129 0.169 1.0 -0.239 9.0 10.0 IGF-1R heterotetramer 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.022 0.083 -9999.0 0.0 -0.401 1.0 1.0 DIAPH1 0.048 0.107 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.051 0.14 0.229 9.0 -9999.0 0.0 9.0 RHOA 0.02 0.083 -9999.0 0.0 -0.401 1.0 1.0 RhoA/GTP -0.093 0.113 -9999.0 0.0 -0.381 2.0 2.0 CTNNA1 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.09 0.132 0.17 1.0 -0.244 9.0 10.0 EFNA1 0.031 0.033 -9999.0 0.0 -0.139 1.0 1.0 LPP -0.073 0.096 0.173 1.0 -0.238 1.0 2.0 Ephrin A1/EPHA2 -0.06 0.128 -9999.0 0.0 -0.238 6.0 6.0 SEC6/SEC8 -0.071 0.126 -9999.0 0.0 -0.326 3.0 3.0 MGAT3 -0.07 0.119 0.183 1.0 -0.22 9.0 10.0 HGF/MET -0.054 0.132 -9999.0 0.0 -0.223 9.0 9.0 HGF 0.019 0.047 -9999.0 0.0 -0.139 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.075 0.136 -9999.0 0.0 -0.245 9.0 9.0 actin cable formation -0.051 0.079 -9999.0 0.0 -0.254 1.0 1.0 KIAA1543 -0.089 0.107 -9999.0 0.0 -0.318 2.0 2.0 KIFC3 -0.07 0.121 0.183 1.0 -0.222 9.0 10.0 NCK1 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.071 0.121 0.183 1.0 -0.222 9.0 10.0 NCK1/GIT1 0.056 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.051 0.14 -9999.0 0.0 -0.229 9.0 9.0 EXOC4 0.031 0.015 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.088 0.1 -9999.0 0.0 -0.22 9.0 9.0 PIP5K1C -0.059 0.11 0.183 1.0 -0.203 9.0 10.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.083 0.101 -9999.0 0.0 -0.462 1.0 1.0 adherens junction assembly -0.047 0.136 0.296 1.0 -0.397 1.0 2.0 IGF-1R heterotetramer/IGF1 -0.05 0.146 -9999.0 0.0 -0.236 8.0 8.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.008 0.087 -9999.0 0.0 -0.284 2.0 2.0 MET 0.026 0.035 -9999.0 0.0 -0.139 1.0 1.0 PLEKHA7 -0.074 0.112 -9999.0 0.0 -0.222 9.0 9.0 mol:GTP 0.061 0.054 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.055 0.143 0.258 1.0 -0.314 3.0 4.0 cortical actin cytoskeleton stabilization -0.075 0.135 -9999.0 0.0 -0.243 9.0 9.0 regulation of cell-cell adhesion -0.088 0.129 0.169 1.0 -0.239 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.075 0.136 -9999.0 0.0 -0.245 9.0 9.0