Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
E-cadherin signaling events	6.0	34.0	5.0	-0.132	0.038	1000.0	-1000.0	0.018	-1000.0
Ephrin A  reverse signaling	5.0	37.0	7.0	-0.102	0.005	1000.0	-1000.0	0.0	-1000.0
FOXM1 transcription factor network	5.0	304.0	51.0	-0.902	0.038	1000.0	-1000.0	-0.087	-1000.0
Thromboxane A2 receptor signaling	4.0	447.0	105.0	-0.251	0.057	1000.0	-1000.0	-0.029	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	298.0	68.0	-0.509	0.322	1000.0	-1000.0	-0.054	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	321.0	74.0	-0.132	0.077	1000.0	-1000.0	-0.063	-1000.0
TCGA08_retinoblastoma	4.0	38.0	8.0	-0.064	0.095	1000.0	-1000.0	-0.004	-1000.0
IL23-mediated signaling events	4.0	272.0	60.0	-0.665	0.04	1000.0	-1000.0	-0.086	-1000.0
IL12-mediated signaling events	3.0	297.0	87.0	-0.401	0.064	1000.0	-1000.0	-0.045	-1000.0
Syndecan-1-mediated signaling events	3.0	134.0	34.0	-0.177	0.038	1000.0	-1000.0	-0.024	-1000.0
PLK2 and PLK4 events	3.0	9.0	3.0	-0.026	-1000.0	1000.0	-1000.0	0.001	-1000.0
Signaling events mediated by the Hedgehog family	3.0	175.0	52.0	-0.115	0.063	1000.0	-1000.0	-0.029	-1000.0
Ephrin B reverse signaling	3.0	155.0	48.0	-0.109	0.044	1000.0	-1000.0	-0.028	-1000.0
Endothelins	3.0	350.0	96.0	-0.334	0.047	1000.0	-1000.0	-0.045	-1000.0
Syndecan-3-mediated signaling events	3.0	108.0	35.0	-0.113	0.069	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	421.0	125.0	-0.114	0.066	1000.0	-1000.0	-0.027	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	254.0	76.0	-0.148	0.059	1000.0	-1000.0	-0.056	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	290.0	136.0	-0.441	0.1	1000.0	-1000.0	-0.033	-1000.0
Visual signal transduction: Cones	2.0	76.0	38.0	-0.06	0.042	1000.0	-1000.0	-0.0	-1000.0
Osteopontin-mediated events	2.0	111.0	38.0	-0.087	0.038	1000.0	-1000.0	-0.021	-1000.0
HIF-1-alpha transcription factor network	2.0	202.0	76.0	-0.211	0.072	1000.0	-1000.0	-0.021	-1000.0
Arf6 signaling events	2.0	153.0	62.0	-0.072	0.079	1000.0	-1000.0	-0.011	-1000.0
EPO signaling pathway	2.0	114.0	55.0	-0.0	0.095	1000.0	-1000.0	-0.027	-1000.0
PLK1 signaling events	2.0	241.0	85.0	-0.172	0.054	1000.0	-1000.0	-0.045	-1000.0
IL1-mediated signaling events	2.0	129.0	62.0	-0.105	0.076	1000.0	-1000.0	-0.028	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	70.0	31.0	-0.1	0.049	1000.0	-1000.0	-0.036	-1000.0
Nongenotropic Androgen signaling	2.0	135.0	52.0	-0.207	0.105	1000.0	-1000.0	-0.021	-1000.0
Wnt signaling	2.0	15.0	7.0	-0.035	0.036	1000.0	-1000.0	-0.006	-1000.0
IL6-mediated signaling events	2.0	151.0	75.0	-0.154	0.054	1000.0	-1000.0	-0.041	-1000.0
Syndecan-4-mediated signaling events	2.0	136.0	67.0	-0.097	0.05	1000.0	-1000.0	-0.031	-1000.0
Aurora B signaling	2.0	154.0	67.0	-0.174	0.06	1000.0	-1000.0	-0.03	-1000.0
Caspase cascade in apoptosis	1.0	106.0	74.0	-0.094	0.055	1000.0	-1000.0	-0.03	-1000.0
Coregulation of Androgen receptor activity	1.0	85.0	76.0	-0.085	0.066	1000.0	-1000.0	-0.026	-1000.0
ErbB4 signaling events	1.0	83.0	69.0	-0.112	0.052	1000.0	-1000.0	-0.034	-1000.0
BARD1 signaling events	1.0	57.0	57.0	-0.061	0.077	1000.0	-1000.0	-0.04	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	28.0	28.0	-0.045	0.05	1000.0	-1000.0	-0.01	-1000.0
Noncanonical Wnt signaling pathway	1.0	51.0	26.0	-0.041	0.038	1000.0	-1000.0	-0.049	-1000.0
Syndecan-2-mediated signaling events	1.0	97.0	69.0	-0.059	0.05	1000.0	-1000.0	-0.023	-1000.0
Cellular roles of Anthrax toxin	1.0	71.0	39.0	-0.185	0.038	1000.0	-1000.0	-0.019	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	75.0	61.0	-0.171	0.07	1000.0	-1000.0	-0.057	-1000.0
Aurora A signaling	1.0	75.0	60.0	-0.086	0.088	1000.0	-1000.0	-0.008	-1000.0
p75(NTR)-mediated signaling	1.0	157.0	125.0	-0.177	0.069	1000.0	-1000.0	-0.025	-1000.0
IL4-mediated signaling events	1.0	139.0	91.0	-0.523	0.276	1000.0	-1000.0	-0.098	-1000.0
BMP receptor signaling	1.0	122.0	81.0	-0.058	0.075	1000.0	-1000.0	-0.02	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	131.0	97.0	-0.087	0.061	1000.0	-1000.0	-0.061	-1000.0
PDGFR-alpha signaling pathway	1.0	76.0	44.0	-0.226	0.045	1000.0	-1000.0	-0.029	-1000.0
amb2 Integrin signaling	1.0	118.0	82.0	-0.085	0.062	1000.0	-1000.0	-0.025	-1000.0
Nectin adhesion pathway	1.0	68.0	63.0	-0.132	0.079	1000.0	-1000.0	-0.052	-1000.0
Glucocorticoid receptor regulatory network	1.0	136.0	114.0	-0.278	0.083	1000.0	-1000.0	-0.042	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	44.0	37.0	-0.078	0.065	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by HDAC Class III	1.0	79.0	40.0	-0.144	0.11	1000.0	-1000.0	-0.033	-1000.0
TRAIL signaling pathway	1.0	56.0	48.0	-0.003	0.068	1000.0	-1000.0	-0.019	-1000.0
Signaling events regulated by Ret tyrosine kinase	1.0	162.0	82.0	-0.058	0.058	1000.0	-1000.0	-0.041	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	68.0	52.0	-0.254	0.113	1000.0	-1000.0	-0.026	-1000.0
S1P1 pathway	1.0	66.0	36.0	-0.125	0.037	1000.0	-1000.0	-0.026	-1000.0
TCGA08_p53	1.0	9.0	7.0	-0.042	0.036	1000.0	-1000.0	-0.004	-1000.0
FAS signaling pathway (CD95)	1.0	61.0	47.0	-0.043	0.052	1000.0	-1000.0	-0.042	-1000.0
Signaling mediated by p38-alpha and p38-beta	1.0	77.0	44.0	-0.06	0.036	1000.0	-1000.0	-0.02	-1000.0
Integrins in angiogenesis	1.0	122.0	84.0	-0.078	0.089	1000.0	-1000.0	-0.032	-1000.0
TCR signaling in naïve CD8+ T cells	1.0	135.0	93.0	-0.176	0.208	1000.0	-1000.0	-0.033	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	45.0	45.0	-0.027	0.068	1000.0	-1000.0	-0.035	-1000.0
Canonical Wnt signaling pathway	1.0	71.0	51.0	-0.17	0.088	1000.0	-1000.0	-0.029	-1000.0
EPHB forward signaling	1.0	123.0	85.0	-0.058	0.079	1000.0	-1000.0	-0.042	-1000.0
Effects of Botulinum toxin	1.0	40.0	26.0	-0.148	0.064	1000.0	-1000.0	-0.0	-1000.0
Glypican 2 network	1.0	6.0	4.0	0.0	0.018	1000.0	-1000.0	0.0	-1000.0
IL27-mediated signaling events	1.0	64.0	51.0	-0.098	0.06	1000.0	-1000.0	-0.055	-1000.0
Class I PI3K signaling events	1.0	110.0	73.0	-0.069	0.049	1000.0	-1000.0	-0.027	-1000.0
BCR signaling pathway	1.0	180.0	99.0	-0.102	0.052	1000.0	-1000.0	-0.053	-1000.0
EGFR-dependent Endothelin signaling events	1.0	28.0	21.0	-0.025	0.062	1000.0	-1000.0	-0.0	-1000.0
Angiopoietin receptor Tie2-mediated signaling	1.0	126.0	88.0	-0.146	0.05	1000.0	-1000.0	-0.06	-1000.0
Rapid glucocorticoid signaling	1.0	28.0	20.0	-0.089	0.038	1000.0	-1000.0	-0.001	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	139.0	120.0	-0.149	0.1	1000.0	-1000.0	-0.04	-1000.0
Visual signal transduction: Rods	1.0	84.0	52.0	-0.06	0.048	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by PRL	1.0	62.0	34.0	-0.178	0.042	1000.0	-1000.0	-0.027	-1000.0
E-cadherin signaling in keratinocytes	1.0	78.0	43.0	-0.131	0.042	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	132.0	78.0	-0.075	0.05	1000.0	-1000.0	-0.051	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	25.0	17.0	-0.038	0.033	1000.0	-1000.0	-0.022	-1000.0
LPA4-mediated signaling events	0.0	7.0	12.0	-0.056	0.01	1000.0	-1000.0	-0.021	-1000.0
ErbB2/ErbB3 signaling events	0.0	51.0	65.0	-0.063	0.05	1000.0	-1000.0	-0.069	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	6.0	23.0	-0.009	0.063	1000.0	-1000.0	-0.013	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	2.0	34.0	-0.037	0.074	1000.0	-1000.0	-0.026	-1000.0
Canonical NF-kappaB pathway	0.0	14.0	39.0	-0.027	0.092	1000.0	-1000.0	-0.011	-1000.0
Signaling events mediated by HDAC Class II	0.0	31.0	75.0	-0.05	0.096	1000.0	-1000.0	-0.012	-1000.0
Circadian rhythm pathway	0.0	17.0	22.0	-0.072	0.061	1000.0	-1000.0	-0.027	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	44.0	54.0	-0.041	0.081	1000.0	-1000.0	-0.024	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	7.0	17.0	-0.002	0.052	1000.0	-1000.0	-0.029	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	0.014	0.038	1000.0	-1000.0	0.02	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	56.0	85.0	-0.315	0.076	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by PTP1B	0.0	67.0	76.0	-0.035	0.057	1000.0	-1000.0	-0.04	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	54.0	65.0	-0.034	0.072	1000.0	-1000.0	-0.033	-1000.0
Arf6 downstream pathway	0.0	11.0	43.0	-0.048	0.072	1000.0	-1000.0	-0.027	-1000.0
Aurora C signaling	0.0	2.0	7.0	-0.0	0.054	1000.0	-1000.0	-0.017	-1000.0
FOXA2 and FOXA3 transcription factor networks	0.0	15.0	46.0	-0.068	0.055	1000.0	-1000.0	-0.053	-1000.0
Glypican 1 network	0.0	39.0	48.0	-0.038	0.068	1000.0	-1000.0	-0.021	-1000.0
Insulin-mediated glucose transport	0.0	12.0	32.0	-0.0	0.051	1000.0	-1000.0	-0.021	-1000.0
mTOR signaling pathway	0.0	22.0	53.0	-0.102	0.052	1000.0	-1000.0	-0.045	-1000.0
IFN-gamma pathway	0.0	41.0	68.0	-0.047	0.052	1000.0	-1000.0	-0.048	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	29.0	68.0	-0.044	0.06	1000.0	-1000.0	-0.028	-1000.0
Ceramide signaling pathway	0.0	73.0	76.0	-0.078	0.067	1000.0	-1000.0	-0.029	-1000.0
Reelin signaling pathway	0.0	30.0	56.0	-0.046	0.095	1000.0	-1000.0	-0.02	-1000.0
S1P5 pathway	0.0	4.0	17.0	-0.006	0.038	1000.0	-1000.0	-0.007	-1000.0
ceramide signaling pathway	0.0	47.0	49.0	-0.027	0.054	1000.0	-1000.0	-0.032	-1000.0
HIF-2-alpha transcription factor network	0.0	29.0	43.0	-0.107	0.095	1000.0	-1000.0	-0.041	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	49.0	83.0	-0.021	0.073	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by HDAC Class I	0.0	34.0	104.0	-0.045	0.072	1000.0	-1000.0	-0.026	-1000.0
FoxO family signaling	0.0	27.0	64.0	-0.122	0.067	1000.0	-1000.0	-0.039	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	11.0	15.0	-0.051	0.036	1000.0	-1000.0	-0.026	-1000.0
Retinoic acid receptors-mediated signaling	0.0	26.0	58.0	-0.057	0.074	1000.0	-1000.0	-0.039	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	27.0	36.0	-0.078	0.074	1000.0	-1000.0	-0.029	-1000.0
Atypical NF-kappaB pathway	0.0	12.0	31.0	-0.008	0.052	1000.0	-1000.0	-0.014	-1000.0
IL2 signaling events mediated by PI3K	0.0	18.0	58.0	-0.013	0.062	1000.0	-1000.0	-0.035	-1000.0
Regulation of p38-alpha and p38-beta	0.0	46.0	54.0	-0.034	0.083	1000.0	-1000.0	-0.024	-1000.0
TCGA08_rtk_signaling	0.0	24.0	26.0	-0.033	0.057	1000.0	-1000.0	-0.006	-1000.0
LPA receptor mediated events	0.0	100.0	102.0	-0.139	0.06	1000.0	-1000.0	-0.085	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.0	0.086	1000.0	-1000.0	-0.023	-1000.0
IL2 signaling events mediated by STAT5	0.0	13.0	22.0	-0.075	0.039	1000.0	-1000.0	-0.026	-1000.0
Arf6 trafficking events	0.0	19.0	71.0	-0.047	0.049	1000.0	-1000.0	-0.026	-1000.0
Regulation of Telomerase	0.0	86.0	102.0	-0.132	0.092	1000.0	-1000.0	-0.046	-1000.0
IGF1 pathway	0.0	17.0	57.0	-0.031	0.091	1000.0	-1000.0	-0.033	-1000.0
Insulin Pathway	0.0	42.0	74.0	-0.039	0.077	1000.0	-1000.0	-0.03	-1000.0
Plasma membrane estrogen receptor signaling	0.0	74.0	86.0	-0.036	0.061	1000.0	-1000.0	-0.044	-1000.0
VEGFR1 specific signals	0.0	10.0	56.0	-0.014	0.079	1000.0	-1000.0	-0.03	-1000.0
S1P3 pathway	0.0	16.0	42.0	-0.04	0.05	1000.0	-1000.0	-0.027	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	11.0	33.0	-0.049	0.088	1000.0	-1000.0	-0.035	-1000.0
PDGFR-beta signaling pathway	0.0	95.0	97.0	-0.068	0.104	1000.0	-1000.0	-0.031	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.035	0.035	1000.0	-1000.0	-0.018	-1000.0
S1P4 pathway	0.0	4.0	25.0	-0.002	0.05	1000.0	-1000.0	-0.018	-1000.0
p38 MAPK signaling pathway	0.0	35.0	44.0	-0.031	0.065	1000.0	-1000.0	-0.02	-1000.0
Arf1 pathway	0.0	2.0	54.0	-0.002	0.046	1000.0	-1000.0	-0.012	-1000.0
Alternative NF-kappaB pathway	0.0	6.0	13.0	0.0	0.058	1000.0	-1000.0	-0.0	-1000.0
Regulation of Androgen receptor activity	0.0	51.0	70.0	-0.18	0.061	1000.0	-1000.0	-0.043	-1000.0
Total	137	11096	7203	-14.0564300919	-991.339062915	131000	-131000	-3.89500620189	-131000