Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	8.0	456.0	51.0	-0.653	0.04	1000.0	-1000.0	-0.065	-1000.0
HIF-1-alpha transcription factor network	6.0	523.0	76.0	-0.529	0.055	1000.0	-1000.0	-0.045	-1000.0
TCGA08_retinoblastoma	5.0	41.0	8.0	-0.099	0.05	1000.0	-1000.0	-0.004	-1000.0
Osteopontin-mediated events	4.0	174.0	38.0	-0.309	0.041	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by the Hedgehog family	4.0	230.0	52.0	-0.27	0.118	1000.0	-1000.0	-0.035	-1000.0
Endothelins	4.0	403.0	96.0	-0.271	0.052	1000.0	-1000.0	-0.054	-1000.0
IL23-mediated signaling events	4.0	272.0	60.0	-0.583	0.038	1000.0	-1000.0	-0.074	-1000.0
IL12-mediated signaling events	3.0	273.0	87.0	-0.285	0.041	1000.0	-1000.0	-0.055	-1000.0
IL4-mediated signaling events	3.0	324.0	91.0	-0.726	0.568	1000.0	-1000.0	-0.118	-1000.0
Fc-epsilon receptor I signaling in mast cells	3.0	317.0	97.0	-0.157	0.041	1000.0	-1000.0	-0.062	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	148.0	44.0	-0.14	0.041	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	377.0	125.0	-0.122	0.056	1000.0	-1000.0	-0.058	-1000.0
IL27-mediated signaling events	3.0	177.0	51.0	-0.217	0.166	1000.0	-1000.0	-0.075	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	3.0	256.0	68.0	-0.47	0.163	1000.0	-1000.0	-0.068	-1000.0
EGFR-dependent Endothelin signaling events	3.0	71.0	21.0	-0.108	0.055	1000.0	-1000.0	-0.02	-1000.0
Visual signal transduction: Rods	3.0	156.0	52.0	-0.217	0.049	1000.0	-1000.0	-0.032	-1000.0
Syndecan-1-mediated signaling events	2.0	79.0	34.0	-0.171	0.041	1000.0	-1000.0	-0.047	-1000.0
Visual signal transduction: Cones	2.0	111.0	38.0	-0.161	0.053	1000.0	-1000.0	-0.003	-1000.0
Noncanonical Wnt signaling pathway	2.0	52.0	26.0	-0.097	0.041	1000.0	-1000.0	-0.082	-1000.0
Syndecan-2-mediated signaling events	2.0	142.0	69.0	-0.192	0.058	1000.0	-1000.0	-0.056	-1000.0
BMP receptor signaling	2.0	198.0	81.0	-0.201	0.075	1000.0	-1000.0	-0.054	-1000.0
amb2 Integrin signaling	2.0	223.0	82.0	-0.152	0.052	1000.0	-1000.0	-0.039	-1000.0
Glucocorticoid receptor regulatory network	2.0	248.0	114.0	-0.404	0.087	1000.0	-1000.0	-0.063	-1000.0
IL1-mediated signaling events	2.0	157.0	62.0	-0.146	0.069	1000.0	-1000.0	-0.042	-1000.0
Ephrin B reverse signaling	2.0	133.0	48.0	-0.123	0.041	1000.0	-1000.0	-0.035	-1000.0
TCGA08_p53	2.0	20.0	7.0	-0.081	0.053	1000.0	-1000.0	-0.007	-1000.0
Integrins in angiogenesis	2.0	181.0	84.0	-0.162	0.048	1000.0	-1000.0	-0.061	-1000.0
TCR signaling in naïve CD8+ T cells	2.0	207.0	93.0	-0.056	0.055	1000.0	-1000.0	-0.045	-1000.0
Glypican 2 network	2.0	9.0	4.0	-0.024	-0.0	1000.0	-1000.0	-0.0	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	79.0	31.0	-0.244	0.043	1000.0	-1000.0	-0.038	-1000.0
Wnt signaling	2.0	20.0	7.0	-0.097	0.04	1000.0	-1000.0	-0.018	-1000.0
IL6-mediated signaling events	2.0	188.0	75.0	-0.453	0.048	1000.0	-1000.0	-0.043	-1000.0
BCR signaling pathway	2.0	273.0	99.0	-0.189	0.07	1000.0	-1000.0	-0.066	-1000.0
Syndecan-4-mediated signaling events	2.0	173.0	67.0	-0.115	0.055	1000.0	-1000.0	-0.055	-1000.0
Plasma membrane estrogen receptor signaling	2.0	254.0	86.0	-0.196	0.185	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	190.0	78.0	-0.124	0.045	1000.0	-1000.0	-0.047	-1000.0
Caspase cascade in apoptosis	1.0	132.0	74.0	-0.063	0.053	1000.0	-1000.0	-0.034	-1000.0
Coregulation of Androgen receptor activity	1.0	90.0	76.0	-0.208	0.052	1000.0	-1000.0	-0.026	-1000.0
ErbB4 signaling events	1.0	94.0	69.0	-0.315	0.074	1000.0	-1000.0	-0.035	-1000.0
PLK2 and PLK4 events	1.0	5.0	3.0	-0.012	0.04	1000.0	-1000.0	-0.003	-1000.0
Thromboxane A2 receptor signaling	1.0	201.0	105.0	-0.088	0.053	1000.0	-1000.0	-0.051	-1000.0
Cellular roles of Anthrax toxin	1.0	55.0	39.0	-0.062	0.037	1000.0	-1000.0	-0.024	-1000.0
Arf6 signaling events	1.0	118.0	62.0	-0.108	0.041	1000.0	-1000.0	-0.021	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	147.0	85.0	-0.128	0.044	1000.0	-1000.0	-0.055	-1000.0
Signaling events mediated by PTP1B	1.0	134.0	76.0	-0.142	0.1	1000.0	-1000.0	-0.039	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	71.0	61.0	-0.166	0.063	1000.0	-1000.0	-0.055	-1000.0
FOXA2 and FOXA3 transcription factor networks	1.0	71.0	46.0	-0.255	0.046	1000.0	-1000.0	-0.088	-1000.0
Glypican 1 network	1.0	52.0	48.0	-0.01	0.056	1000.0	-1000.0	-0.034	-1000.0
PLK1 signaling events	1.0	89.0	85.0	-0.138	0.06	1000.0	-1000.0	-0.044	-1000.0
mTOR signaling pathway	1.0	102.0	53.0	-0.093	0.04	1000.0	-1000.0	-0.049	-1000.0
IFN-gamma pathway	1.0	101.0	68.0	-0.11	0.041	1000.0	-1000.0	-0.058	-1000.0
Nectin adhesion pathway	1.0	105.0	63.0	-0.098	0.059	1000.0	-1000.0	-0.061	-1000.0
Ceramide signaling pathway	1.0	92.0	76.0	-0.063	0.057	1000.0	-1000.0	-0.036	-1000.0
Reelin signaling pathway	1.0	57.0	56.0	-0.041	0.059	1000.0	-1000.0	-0.037	-1000.0
TRAIL signaling pathway	1.0	83.0	48.0	-0.029	0.041	1000.0	-1000.0	-0.03	-1000.0
Signaling events regulated by Ret tyrosine kinase	1.0	82.0	82.0	-0.051	0.061	1000.0	-1000.0	-0.075	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	71.0	52.0	-0.091	0.086	1000.0	-1000.0	-0.04	-1000.0
HIF-2-alpha transcription factor network	1.0	64.0	43.0	-0.168	0.077	1000.0	-1000.0	-0.045	-1000.0
S1P1 pathway	1.0	57.0	36.0	-0.132	0.04	1000.0	-1000.0	-0.042	-1000.0
FoxO family signaling	1.0	69.0	64.0	-0.243	0.055	1000.0	-1000.0	-0.037	-1000.0
FAS signaling pathway (CD95)	1.0	91.0	47.0	-0.111	0.051	1000.0	-1000.0	-0.033	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	17.0	15.0	-0.041	0.04	1000.0	-1000.0	-0.026	-1000.0
Syndecan-3-mediated signaling events	1.0	68.0	35.0	-0.192	0.062	1000.0	-1000.0	-0.049	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	65.0	45.0	-0.059	0.056	1000.0	-1000.0	-0.045	-1000.0
Canonical Wnt signaling pathway	1.0	80.0	51.0	-0.166	0.094	1000.0	-1000.0	-0.046	-1000.0
EPHB forward signaling	1.0	131.0	85.0	-0.071	0.084	1000.0	-1000.0	-0.074	-1000.0
Effects of Botulinum toxin	1.0	33.0	26.0	-0.032	0.036	1000.0	-1000.0	-0.011	-1000.0
Nongenotropic Androgen signaling	1.0	59.0	52.0	-0.029	0.051	1000.0	-1000.0	-0.044	-1000.0
TCGA08_rtk_signaling	1.0	31.0	26.0	-0.084	0.041	1000.0	-1000.0	-0.005	-1000.0
LPA receptor mediated events	1.0	158.0	102.0	-0.222	0.068	1000.0	-1000.0	-0.076	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	116.0	74.0	-0.128	0.06	1000.0	-1000.0	-0.078	-1000.0
IGF1 pathway	1.0	65.0	57.0	-0.051	0.065	1000.0	-1000.0	-0.049	-1000.0
Insulin Pathway	1.0	131.0	74.0	-0.126	0.067	1000.0	-1000.0	-0.051	-1000.0
VEGFR1 specific signals	1.0	57.0	56.0	-0.022	0.04	1000.0	-1000.0	-0.049	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	33.0	33.0	-0.133	0.099	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling in keratinocytes	1.0	43.0	43.0	-0.084	0.042	1000.0	-1000.0	-0.052	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.03	0.03	1000.0	-1000.0	-0.018	-1000.0
E-cadherin signaling events	1.0	7.0	5.0	-0.006	0.036	1000.0	-1000.0	0.01	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	22.0	17.0	-0.0	0.044	1000.0	-1000.0	-0.028	-1000.0
Aurora B signaling	1.0	130.0	67.0	-0.127	0.045	1000.0	-1000.0	-0.056	-1000.0
LPA4-mediated signaling events	0.0	5.0	12.0	-0.004	0.058	1000.0	-1000.0	-0.016	-1000.0
ErbB2/ErbB3 signaling events	0.0	26.0	65.0	-0.022	0.069	1000.0	-1000.0	-0.067	-1000.0
Regulation of nuclear SMAD2/3 signaling	0.0	94.0	136.0	-0.165	0.161	1000.0	-1000.0	-0.045	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	7.0	23.0	-0.003	0.07	1000.0	-1000.0	-0.032	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	8.0	34.0	-0.044	0.087	1000.0	-1000.0	-0.033	-1000.0
Canonical NF-kappaB pathway	0.0	11.0	39.0	-0.0	0.083	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by HDAC Class II	0.0	42.0	75.0	-0.118	0.078	1000.0	-1000.0	-0.024	-1000.0
BARD1 signaling events	0.0	18.0	57.0	-0.073	0.075	1000.0	-1000.0	-0.043	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	20.0	28.0	-0.033	0.042	1000.0	-1000.0	-0.018	-1000.0
Circadian rhythm pathway	0.0	14.0	22.0	-0.096	0.08	1000.0	-1000.0	-0.04	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	26.0	54.0	-0.04	0.053	1000.0	-1000.0	-0.046	-1000.0
Ephrin A  reverse signaling	0.0	6.0	7.0	-0.0	0.03	1000.0	-1000.0	-0.01	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	4.0	17.0	-0.003	0.086	1000.0	-1000.0	-0.032	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.038	0.059	1000.0	-1000.0	0.013	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	60.0	65.0	-0.245	0.08	1000.0	-1000.0	-0.043	-1000.0
Aurora A signaling	0.0	45.0	60.0	-0.064	0.082	1000.0	-1000.0	-0.018	-1000.0
p75(NTR)-mediated signaling	0.0	112.0	125.0	-0.176	0.089	1000.0	-1000.0	-0.061	-1000.0
Arf6 downstream pathway	0.0	26.0	43.0	-0.042	0.055	1000.0	-1000.0	-0.035	-1000.0
Aurora C signaling	0.0	5.0	7.0	-0.026	0.044	1000.0	-1000.0	-0.019	-1000.0
EPO signaling pathway	0.0	18.0	55.0	0.0	0.082	1000.0	-1000.0	-0.039	-1000.0
Insulin-mediated glucose transport	0.0	8.0	32.0	-0.024	0.052	1000.0	-1000.0	-0.027	-1000.0
PDGFR-alpha signaling pathway	0.0	35.0	44.0	-0.068	0.066	1000.0	-1000.0	-0.048	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	56.0	68.0	-0.024	0.066	1000.0	-1000.0	-0.041	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	14.0	37.0	-0.004	0.092	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by HDAC Class III	0.0	20.0	40.0	-0.09	0.072	1000.0	-1000.0	-0.024	-1000.0
S1P5 pathway	0.0	8.0	17.0	-0.031	0.041	1000.0	-1000.0	-0.012	-1000.0
ceramide signaling pathway	0.0	33.0	49.0	-0.063	0.045	1000.0	-1000.0	-0.035	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	24.0	83.0	-0.033	0.075	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class I	0.0	20.0	104.0	-0.051	0.085	1000.0	-1000.0	-0.038	-1000.0
Retinoic acid receptors-mediated signaling	0.0	44.0	58.0	-0.017	0.081	1000.0	-1000.0	-0.039	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	12.0	36.0	-0.078	0.08	1000.0	-1000.0	-0.04	-1000.0
Atypical NF-kappaB pathway	0.0	14.0	31.0	0.0	0.056	1000.0	-1000.0	-0.018	-1000.0
IL2 signaling events mediated by PI3K	0.0	39.0	58.0	-0.03	0.093	1000.0	-1000.0	-0.039	-1000.0
Regulation of p38-alpha and p38-beta	0.0	35.0	54.0	-0.032	0.075	1000.0	-1000.0	-0.034	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	56.0	76.0	-0.049	0.059	1000.0	-1000.0	-0.075	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.0	0.067	1000.0	-1000.0	-0.034	-1000.0
IL2 signaling events mediated by STAT5	0.0	13.0	22.0	-0.064	0.046	1000.0	-1000.0	-0.047	-1000.0
Class I PI3K signaling events	0.0	51.0	73.0	-0.035	0.041	1000.0	-1000.0	-0.044	-1000.0
Arf6 trafficking events	0.0	10.0	71.0	-0.044	0.047	1000.0	-1000.0	-0.033	-1000.0
Regulation of Telomerase	0.0	95.0	102.0	-0.118	0.077	1000.0	-1000.0	-0.035	-1000.0
S1P3 pathway	0.0	27.0	42.0	-0.033	0.042	1000.0	-1000.0	-0.036	-1000.0
Angiopoietin receptor Tie2-mediated signaling	0.0	53.0	88.0	-0.112	0.095	1000.0	-1000.0	-0.072	-1000.0
Rapid glucocorticoid signaling	0.0	11.0	20.0	-0.0	0.041	1000.0	-1000.0	-0.004	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	0.0	87.0	120.0	-0.088	0.084	1000.0	-1000.0	-0.054	-1000.0
PDGFR-beta signaling pathway	0.0	38.0	97.0	-0.045	0.092	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by PRL	0.0	32.0	34.0	-0.108	0.059	1000.0	-1000.0	-0.042	-1000.0
S1P4 pathway	0.0	12.0	25.0	-0.0	0.048	1000.0	-1000.0	-0.026	-1000.0
p38 MAPK signaling pathway	0.0	36.0	44.0	-0.075	0.064	1000.0	-1000.0	-0.03	-1000.0
Arf1 pathway	0.0	5.0	54.0	-0.0	0.047	1000.0	-1000.0	-0.018	-1000.0
Alternative NF-kappaB pathway	0.0	1.0	13.0	-0.0	0.096	1000.0	-1000.0	-0.0	-1000.0
Regulation of Androgen receptor activity	0.0	59.0	70.0	-0.212	0.051	1000.0	-1000.0	-0.046	-1000.0
Total	146	12115	7203	-15.7110598125	8.67191909309	131000	-131000	-5.25736050864	-131000