E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.029 0.145 -9999.0 0.0 -0.426 13.0 13.0 KLHL20 -0.009 0.112 0.187 1.0 -0.309 11.0 12.0 CYFIP2 0.028 0.048 -9999.0 0.0 -0.509 1.0 1.0 Rac1/GDP 0.001 0.11 0.246 1.0 -0.3 7.0 8.0 ENAH -0.026 0.143 -9999.0 0.0 -0.42 13.0 13.0 AP1M1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.062 -9999.0 0.0 -0.509 2.0 2.0 CTNNB1 0.031 0.019 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.013 0.079 -9999.0 0.0 -0.293 1.0 1.0 ABI1/Sra1/Nap1 -0.033 0.061 -9999.0 0.0 -0.203 12.0 12.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.059 0.082 -9999.0 0.0 -0.29 6.0 6.0 RAPGEF1 -0.019 0.127 -9999.0 0.0 -0.415 8.0 8.0 CTNND1 0.019 0.097 -9999.0 0.0 -0.509 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.023 0.154 -9999.0 0.0 -0.428 14.0 14.0 CRK -0.016 0.134 -9999.0 0.0 -0.404 12.0 12.0 E-cadherin/gamma catenin/alpha catenin 0.022 0.126 -9999.0 0.0 -0.333 16.0 16.0 alphaE/beta7 Integrin 0.05 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.049 -9999.0 0.0 -0.183 5.0 5.0 Rap1/GTP/I-afadin 0.057 0.047 -9999.0 0.0 -0.289 2.0 2.0 DLG1 -0.032 0.149 -9999.0 0.0 -0.419 14.0 14.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.014 0.048 -9999.0 0.0 -0.24 3.0 3.0 MLLT4 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.058 0.047 -9999.0 0.0 -0.289 2.0 2.0 PI3K -0.015 0.063 -9999.0 0.0 -0.314 3.0 3.0 ARF6 0.027 0.063 -9999.0 0.0 -0.509 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.002 0.137 -9999.0 0.0 -0.39 16.0 16.0 TIAM1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.045 0.096 -9999.0 0.0 -0.271 11.0 11.0 AKT1 0.033 0.071 0.171 4.0 -0.222 3.0 7.0 PIK3R1 0.01 0.092 -9999.0 0.0 -0.509 4.0 4.0 CDH1 0.012 0.106 -9999.0 0.0 -0.509 6.0 6.0 RhoA/GDP 0.006 0.107 0.249 1.0 -0.299 6.0 7.0 actin cytoskeleton organization -0.004 0.083 0.155 1.0 -0.231 9.0 10.0 CDC42/GDP 0.004 0.11 0.249 1.0 -0.296 8.0 9.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.016 0.11 -9999.0 0.0 -0.28 20.0 20.0 ITGB7 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.049 0.102 -9999.0 0.0 -0.288 11.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.039 0.069 -9999.0 0.0 -0.269 6.0 6.0 mol:GDP -0.016 0.116 0.247 1.0 -0.341 8.0 9.0 CDC42/GTP/IQGAP1 0.047 0.012 -9999.0 0.0 -9999.0 0.0 0.0 JUP -0.005 0.14 -9999.0 0.0 -0.509 11.0 11.0 p120 catenin/RhoA/GDP 0.01 0.118 -9999.0 0.0 -0.332 3.0 3.0 RAC1/GTP/IQGAP1 0.047 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.046 0.039 -9999.0 0.0 -0.371 1.0 1.0 RHOA 0.032 0.012 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.035 0.009 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.009 0.077 0.118 1.0 -0.223 13.0 14.0 NME1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.033 0.152 -9999.0 0.0 -0.424 15.0 15.0 regulation of cell-cell adhesion -0.0 0.062 -9999.0 0.0 -0.257 1.0 1.0 WASF2 -0.005 0.047 -9999.0 0.0 -0.138 7.0 7.0 Rap1/GTP 0.013 0.087 -9999.0 0.0 -0.328 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.125 -9999.0 0.0 -0.29 16.0 16.0 CCND1 -0.012 0.095 0.135 1.0 -0.281 13.0 14.0 VAV2 -0.049 0.243 -9999.0 0.0 -0.691 15.0 15.0 RAP1/GDP 0.015 0.101 0.266 1.0 -0.314 2.0 3.0 adherens junction assembly -0.032 0.148 -9999.0 0.0 -0.41 15.0 15.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.047 -9999.0 0.0 -0.509 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.029 0.113 -9999.0 0.0 -0.284 14.0 14.0 E-cadherin/beta catenin -0.001 0.075 -9999.0 0.0 -0.337 7.0 7.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.026 0.142 -9999.0 0.0 -0.43 12.0 12.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.509 2.0 2.0 Rac1/GTP -0.068 0.164 -9999.0 0.0 -0.508 14.0 14.0 E-cadherin/beta catenin/alpha catenin 0.044 0.081 -9999.0 0.0 -0.316 6.0 6.0 ITGAE 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.024 0.157 -9999.0 0.0 -0.438 14.0 14.0