Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.003 0.085 -9999.0 0.0 -0.274 11.0 11.0 epithelial cell differentiation 0.04 0.093 -9999.0 0.0 -0.269 11.0 11.0 CYFIP2 0.028 0.048 -9999.0 0.0 -0.509 1.0 1.0 ENAH -0.005 0.115 0.269 4.0 -0.333 5.0 9.0 EGFR -0.031 0.17 -9999.0 0.0 -0.509 17.0 17.0 EPHA2 -0.012 0.147 -9999.0 0.0 -0.509 12.0 12.0 MYO6 -0.008 0.091 -9999.0 0.0 -0.284 13.0 13.0 CTNNB1 0.031 0.019 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.054 0.056 -9999.0 0.0 -0.318 2.0 2.0 AQP5 -0.085 0.188 -9999.0 0.0 -0.506 23.0 23.0 CTNND1 0.019 0.097 -9999.0 0.0 -0.509 5.0 5.0 mol:PI-4-5-P2 -0.007 0.077 -9999.0 0.0 -0.257 12.0 12.0 regulation of calcium-dependent cell-cell adhesion -0.019 0.097 -9999.0 0.0 -0.289 15.0 15.0 EGF -0.033 0.153 -9999.0 0.0 -0.509 13.0 13.0 NCKAP1 0.029 0.049 -9999.0 0.0 -0.509 1.0 1.0 AQP3 -0.118 0.203 -9999.0 0.0 -0.504 30.0 30.0 cortical microtubule organization 0.04 0.093 -9999.0 0.0 -0.269 11.0 11.0 GO:0000145 -0.028 0.067 -9999.0 0.0 -0.246 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.045 0.096 -9999.0 0.0 -0.271 11.0 11.0 MLLT4 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.054 0.104 -9999.0 0.0 -0.427 7.0 7.0 ARF6 0.027 0.063 -9999.0 0.0 -0.509 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.022 0.121 -9999.0 0.0 -0.369 10.0 10.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.014 0.063 -9999.0 0.0 -0.307 3.0 3.0 PVRL2 0.031 0.047 -9999.0 0.0 -0.509 1.0 1.0 ZYX -0.009 0.082 -9999.0 0.0 -0.26 13.0 13.0 ARF6/GTP 0.023 0.127 -9999.0 0.0 -0.371 10.0 10.0 CDH1 0.012 0.106 -9999.0 0.0 -0.509 6.0 6.0 EGFR/EGFR/EGF/EGF -0.04 0.156 -9999.0 0.0 -0.327 30.0 30.0 RhoA/GDP 0.041 0.09 -9999.0 0.0 -0.255 11.0 11.0 actin cytoskeleton organization -0.033 0.095 -9999.0 0.0 -0.317 12.0 12.0 IGF-1R heterotetramer -0.005 0.14 -9999.0 0.0 -0.508 11.0 11.0 GIT1 0.027 0.063 -9999.0 0.0 -0.509 2.0 2.0 IGF1R -0.005 0.14 -9999.0 0.0 -0.509 11.0 11.0 IGF1 -0.048 0.183 -9999.0 0.0 -0.509 20.0 20.0 DIAPH1 0.01 0.193 -9999.0 0.0 -0.607 10.0 10.0 Wnt receptor signaling pathway -0.04 0.093 0.269 11.0 -9999.0 0.0 11.0 RHOA 0.032 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.051 0.096 -9999.0 0.0 -0.416 6.0 6.0 CTNNA1 0.035 0.009 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.034 0.098 -9999.0 0.0 -0.325 12.0 12.0 EFNA1 0.022 0.077 -9999.0 0.0 -0.509 3.0 3.0 LPP -0.021 0.06 -9999.0 0.0 -0.261 7.0 7.0 Ephrin A1/EPHA2 0.001 0.132 -9999.0 0.0 -0.305 21.0 21.0 SEC6/SEC8 -0.006 0.072 -9999.0 0.0 -0.255 10.0 10.0 MGAT3 -0.02 0.099 -9999.0 0.0 -0.293 15.0 15.0 HGF/MET 0.026 0.092 -9999.0 0.0 -0.257 12.0 12.0 HGF 0.032 0.023 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.003 0.086 -9999.0 0.0 -0.276 11.0 11.0 actin cable formation 0.047 0.128 0.288 9.0 -0.34 3.0 12.0 KIAA1543 -0.033 0.076 -9999.0 0.0 -0.258 13.0 13.0 KIFC3 -0.004 0.076 -9999.0 0.0 -0.26 11.0 11.0 NCK1 0.024 0.046 -9999.0 0.0 -0.509 1.0 1.0 EXOC3 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.004 0.077 -9999.0 0.0 -0.263 11.0 11.0 NCK1/GIT1 0.03 0.062 -9999.0 0.0 -0.371 3.0 3.0 mol:GDP 0.04 0.093 -9999.0 0.0 -0.269 11.0 11.0 EXOC4 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.029 0.064 -9999.0 0.0 -0.258 11.0 11.0 PIP5K1C -0.007 0.078 -9999.0 0.0 -0.261 12.0 12.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.002 0.133 0.294 5.0 -0.391 5.0 10.0 adherens junction assembly -0.029 0.117 -9999.0 0.0 -0.556 3.0 3.0 IGF-1R heterotetramer/IGF1 -0.035 0.149 -9999.0 0.0 -0.287 35.0 35.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.047 0.039 -9999.0 0.0 -0.371 1.0 1.0 MET 0.023 0.077 -9999.0 0.0 -0.509 3.0 3.0 PLEKHA7 -0.003 0.078 -9999.0 0.0 -0.26 11.0 11.0 mol:GTP 0.021 0.119 -9999.0 0.0 -0.366 10.0 10.0 establishment of epithelial cell apical/basal polarity -0.032 0.066 -9999.0 0.0 -0.294 1.0 1.0 cortical actin cytoskeleton stabilization -0.003 0.085 -9999.0 0.0 -0.274 11.0 11.0 regulation of cell-cell adhesion -0.033 0.095 -9999.0 0.0 -0.317 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.003 0.086 -9999.0 0.0 -0.276 11.0 11.0