Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
HIF-1-alpha transcription factor network	29.0	2262.0	76.0	-0.3	0.036	1000.0	-1000.0	-0.02	-1000.0
TCGA08_retinoblastoma	26.0	214.0	8.0	-0.077	0.086	1000.0	-1000.0	-0.006	-1000.0
Signaling events mediated by the Hedgehog family	22.0	1181.0	52.0	-0.257	0.052	1000.0	-1000.0	-0.028	-1000.0
IL4-mediated signaling events	21.0	1972.0	91.0	-0.563	0.514	1000.0	-1000.0	-0.077	-1000.0
Signaling mediated by p38-alpha and p38-beta	20.0	880.0	44.0	-0.165	0.036	1000.0	-1000.0	-0.014	-1000.0
IL23-mediated signaling events	20.0	1223.0	60.0	-0.505	0.035	1000.0	-1000.0	-0.069	-1000.0
Osteopontin-mediated events	19.0	723.0	38.0	-0.204	0.037	1000.0	-1000.0	-0.034	-1000.0
Endothelins	19.0	1854.0	96.0	-0.237	0.036	1000.0	-1000.0	-0.032	-1000.0
Glucocorticoid receptor regulatory network	18.0	2138.0	114.0	-0.458	0.286	1000.0	-1000.0	-0.047	-1000.0
Wnt signaling	18.0	128.0	7.0	-0.127	0.03	1000.0	-1000.0	-0.013	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	18.0	1274.0	68.0	-0.394	0.185	1000.0	-1000.0	-0.063	-1000.0
Noncanonical Wnt signaling pathway	17.0	450.0	26.0	-0.127	0.037	1000.0	-1000.0	-0.046	-1000.0
Syndecan-1-mediated signaling events	16.0	544.0	34.0	-0.125	0.04	1000.0	-1000.0	-0.029	-1000.0
Fc-epsilon receptor I signaling in mast cells	16.0	1635.0	97.0	-0.112	0.047	1000.0	-1000.0	-0.047	-1000.0
EPHB forward signaling	16.0	1373.0	85.0	-0.11	0.078	1000.0	-1000.0	-0.058	-1000.0
Ephrin B reverse signaling	15.0	736.0	48.0	-0.1	0.045	1000.0	-1000.0	-0.022	-1000.0
FOXM1 transcription factor network	15.0	804.0	51.0	-0.247	0.042	1000.0	-1000.0	-0.084	-1000.0
Thromboxane A2 receptor signaling	14.0	1568.0	105.0	-0.163	0.054	1000.0	-1000.0	-0.037	-1000.0
BCR signaling pathway	14.0	1442.0	99.0	-0.199	0.054	1000.0	-1000.0	-0.051	-1000.0
IGF1 pathway	14.0	815.0	57.0	-0.066	0.066	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	14.0	1161.0	78.0	-0.172	0.072	1000.0	-1000.0	-0.044	-1000.0
TCR signaling in naïve CD8+ T cells	13.0	1230.0	93.0	-0.101	0.051	1000.0	-1000.0	-0.04	-1000.0
Calcium signaling in the CD4+ TCR pathway	13.0	424.0	31.0	-0.204	0.041	1000.0	-1000.0	-0.025	-1000.0
EGFR-dependent Endothelin signaling events	13.0	280.0	21.0	-0.078	0.051	1000.0	-1000.0	-0.025	-1000.0
IL12-mediated signaling events	12.0	1080.0	87.0	-0.212	0.037	1000.0	-1000.0	-0.047	-1000.0
Nectin adhesion pathway	12.0	809.0	63.0	-0.087	0.057	1000.0	-1000.0	-0.042	-1000.0
TCGA08_p53	12.0	87.0	7.0	-0.037	0.036	1000.0	-1000.0	-0.008	-1000.0
Glypican 1 network	11.0	562.0	48.0	-0.046	0.036	1000.0	-1000.0	-0.021	-1000.0
IL1-mediated signaling events	11.0	688.0	62.0	-0.153	0.072	1000.0	-1000.0	-0.033	-1000.0
S1P1 pathway	11.0	397.0	36.0	-0.196	0.036	1000.0	-1000.0	-0.03	-1000.0
IL27-mediated signaling events	11.0	601.0	51.0	-0.186	0.122	1000.0	-1000.0	-0.057	-1000.0
LPA receptor mediated events	11.0	1205.0	102.0	-0.197	0.037	1000.0	-1000.0	-0.055	-1000.0
BMP receptor signaling	10.0	856.0	81.0	-0.154	0.059	1000.0	-1000.0	-0.04	-1000.0
IFN-gamma pathway	10.0	696.0	68.0	-0.104	0.05	1000.0	-1000.0	-0.044	-1000.0
Syndecan-2-mediated signaling events	9.0	655.0	69.0	-0.122	0.039	1000.0	-1000.0	-0.037	-1000.0
amb2 Integrin signaling	9.0	754.0	82.0	-0.11	0.041	1000.0	-1000.0	-0.031	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	9.0	669.0	74.0	-0.118	0.054	1000.0	-1000.0	-0.064	-1000.0
Syndecan-4-mediated signaling events	9.0	667.0	67.0	-0.064	0.039	1000.0	-1000.0	-0.035	-1000.0
Caspase cascade in apoptosis	8.0	655.0	74.0	-0.062	0.05	1000.0	-1000.0	-0.033	-1000.0
Arf6 signaling events	8.0	530.0	62.0	-0.072	0.075	1000.0	-1000.0	-0.012	-1000.0
HIF-2-alpha transcription factor network	8.0	386.0	43.0	-0.072	0.053	1000.0	-1000.0	-0.042	-1000.0
FAS signaling pathway (CD95)	8.0	405.0	47.0	-0.157	0.039	1000.0	-1000.0	-0.036	-1000.0
E-cadherin signaling in keratinocytes	8.0	363.0	43.0	-0.04	0.052	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by PTP1B	7.0	601.0	76.0	-0.092	0.071	1000.0	-1000.0	-0.038	-1000.0
Hedgehog signaling events mediated by Gli proteins	7.0	459.0	65.0	-0.151	0.078	1000.0	-1000.0	-0.036	-1000.0
Arf6 downstream pathway	7.0	308.0	43.0	-0.049	0.052	1000.0	-1000.0	-0.029	-1000.0
IL6-mediated signaling events	7.0	535.0	75.0	-0.084	0.052	1000.0	-1000.0	-0.037	-1000.0
Plasma membrane estrogen receptor signaling	7.0	619.0	86.0	-0.058	0.053	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling events	7.0	39.0	5.0	-0.005	0.031	1000.0	-1000.0	0.017	-1000.0
Regulation of nuclear SMAD2/3 signaling	6.0	838.0	136.0	-0.405	0.093	1000.0	-1000.0	-0.027	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	170.0	28.0	-0.033	0.046	1000.0	-1000.0	-0.013	-1000.0
PDGFR-alpha signaling pathway	6.0	292.0	44.0	-0.117	0.057	1000.0	-1000.0	-0.036	-1000.0
mTOR signaling pathway	6.0	359.0	53.0	-0.016	0.093	1000.0	-1000.0	-0.033	-1000.0
Reelin signaling pathway	6.0	353.0	56.0	-0.075	0.083	1000.0	-1000.0	-0.034	-1000.0
TRAIL signaling pathway	6.0	315.0	48.0	-0.026	0.051	1000.0	-1000.0	-0.026	-1000.0
Signaling mediated by p38-gamma and p38-delta	6.0	90.0	15.0	-0.026	0.035	1000.0	-1000.0	-0.036	-1000.0
Syndecan-3-mediated signaling events	6.0	223.0	35.0	-0.132	0.072	1000.0	-1000.0	-0.031	-1000.0
Integrins in angiogenesis	6.0	556.0	84.0	-0.104	0.07	1000.0	-1000.0	-0.036	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	6.0	305.0	45.0	-0.056	0.042	1000.0	-1000.0	-0.042	-1000.0
Canonical Wnt signaling pathway	6.0	354.0	51.0	-0.121	0.078	1000.0	-1000.0	-0.041	-1000.0
Glypican 2 network	6.0	24.0	4.0	0.0	0.006	1000.0	-1000.0	0.0	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	456.0	76.0	-0.068	0.059	1000.0	-1000.0	-0.05	-1000.0
VEGFR1 specific signals	6.0	368.0	56.0	-0.044	0.041	1000.0	-1000.0	-0.051	-1000.0
Ras signaling in the CD4+ TCR pathway	6.0	115.0	17.0	-0.01	0.035	1000.0	-1000.0	-0.013	-1000.0
Coregulation of Androgen receptor activity	5.0	452.0	76.0	-0.186	0.058	1000.0	-1000.0	-0.021	-1000.0
PLK2 and PLK4 events	5.0	16.0	3.0	-0.007	0.034	1000.0	-1000.0	-0.007	-1000.0
Visual signal transduction: Cones	5.0	212.0	38.0	-0.023	0.05	1000.0	-1000.0	-0.001	-1000.0
Cellular roles of Anthrax toxin	5.0	217.0	39.0	-0.053	0.036	1000.0	-1000.0	-0.019	-1000.0
Presenilin action in Notch and Wnt signaling	5.0	365.0	61.0	-0.121	0.072	1000.0	-1000.0	-0.037	-1000.0
p75(NTR)-mediated signaling	5.0	645.0	125.0	-0.132	0.086	1000.0	-1000.0	-0.042	-1000.0
Nongenotropic Androgen signaling	5.0	308.0	52.0	-0.082	0.064	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	5.0	703.0	125.0	-0.034	0.042	1000.0	-1000.0	-0.042	-1000.0
IL2 signaling events mediated by STAT5	5.0	114.0	22.0	-0.068	0.04	1000.0	-1000.0	-0.024	-1000.0
S1P3 pathway	5.0	216.0	42.0	-0.045	0.046	1000.0	-1000.0	-0.031	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	5.0	624.0	120.0	-0.139	0.095	1000.0	-1000.0	-0.043	-1000.0
Visual signal transduction: Rods	5.0	281.0	52.0	-0.071	0.053	1000.0	-1000.0	-0.032	-1000.0
ErbB2/ErbB3 signaling events	4.0	304.0	65.0	-0.04	0.051	1000.0	-1000.0	-0.053	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	4.0	222.0	54.0	-0.055	0.052	1000.0	-1000.0	-0.036	-1000.0
JNK signaling in the CD4+ TCR pathway	4.0	73.0	17.0	-0.019	0.061	1000.0	-1000.0	-0.021	-1000.0
FOXA2 and FOXA3 transcription factor networks	4.0	223.0	46.0	-0.066	0.053	1000.0	-1000.0	-0.085	-1000.0
PLK1 signaling events	4.0	363.0	85.0	-0.024	0.104	1000.0	-1000.0	-0.03	-1000.0
Ceramide signaling pathway	4.0	323.0	76.0	-0.048	0.071	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by HDAC Class III	4.0	165.0	40.0	-0.064	0.066	1000.0	-1000.0	-0.031	-1000.0
FoxO family signaling	4.0	292.0	64.0	-0.122	0.067	1000.0	-1000.0	-0.039	-1000.0
Retinoic acid receptors-mediated signaling	4.0	236.0	58.0	-0.056	0.068	1000.0	-1000.0	-0.035	-1000.0
IL2 signaling events mediated by PI3K	4.0	271.0	58.0	-0.08	0.038	1000.0	-1000.0	-0.02	-1000.0
TCGA08_rtk_signaling	4.0	118.0	26.0	-0.067	0.068	1000.0	-1000.0	-0.005	-1000.0
Class I PI3K signaling events	4.0	332.0	73.0	-0.032	0.043	1000.0	-1000.0	-0.03	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	357.0	88.0	-0.045	0.04	1000.0	-1000.0	-0.06	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	4.0	140.0	33.0	-0.07	0.076	1000.0	-1000.0	-0.034	-1000.0
PDGFR-beta signaling pathway	4.0	389.0	97.0	-0.057	0.088	1000.0	-1000.0	-0.045	-1000.0
Regulation of Androgen receptor activity	4.0	318.0	70.0	-0.205	0.057	1000.0	-1000.0	-0.045	-1000.0
Aurora B signaling	4.0	305.0	67.0	-0.1	0.058	1000.0	-1000.0	-0.043	-1000.0
ErbB4 signaling events	3.0	274.0	69.0	-0.084	0.05	1000.0	-1000.0	-0.043	-1000.0
a4b1 and a4b7 Integrin signaling	3.0	18.0	5.0	0.016	0.038	1000.0	-1000.0	0.017	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	335.0	85.0	-0.096	0.08	1000.0	-1000.0	-0.038	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	125.0	37.0	-0.038	0.064	1000.0	-1000.0	-0.03	-1000.0
S1P5 pathway	3.0	67.0	17.0	-0.007	0.035	1000.0	-1000.0	-0.009	-1000.0
ceramide signaling pathway	3.0	169.0	49.0	-0.026	0.048	1000.0	-1000.0	-0.03	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	205.0	52.0	-0.025	0.086	1000.0	-1000.0	-0.035	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	122.0	36.0	-0.05	0.066	1000.0	-1000.0	-0.031	-1000.0
Atypical NF-kappaB pathway	3.0	107.0	31.0	-0.003	0.037	1000.0	-1000.0	-0.013	-1000.0
Regulation of Telomerase	3.0	353.0	102.0	-0.097	0.085	1000.0	-1000.0	-0.041	-1000.0
Insulin Pathway	3.0	286.0	74.0	-0.045	0.092	1000.0	-1000.0	-0.032	-1000.0
S1P4 pathway	3.0	97.0	25.0	-0.014	0.046	1000.0	-1000.0	-0.022	-1000.0
LPA4-mediated signaling events	2.0	31.0	12.0	-0.016	0.059	1000.0	-1000.0	-0.024	-1000.0
Aurora A signaling	2.0	159.0	60.0	-0.011	0.062	1000.0	-1000.0	-0.014	-1000.0
EPO signaling pathway	2.0	145.0	55.0	-0.004	0.064	1000.0	-1000.0	-0.032	-1000.0
Insulin-mediated glucose transport	2.0	74.0	32.0	-0.025	0.043	1000.0	-1000.0	-0.022	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	186.0	68.0	-0.041	0.072	1000.0	-1000.0	-0.027	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	178.0	82.0	-0.031	0.064	1000.0	-1000.0	-0.055	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	175.0	83.0	-0.025	0.065	1000.0	-1000.0	-0.019	-1000.0
Regulation of p38-alpha and p38-beta	2.0	134.0	54.0	-0.003	0.079	1000.0	-1000.0	-0.024	-1000.0
Arf6 trafficking events	2.0	181.0	71.0	-0.035	0.041	1000.0	-1000.0	-0.027	-1000.0
p38 MAPK signaling pathway	2.0	97.0	44.0	-0.011	0.065	1000.0	-1000.0	-0.026	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	27.0	23.0	0.004	0.063	1000.0	-1000.0	-0.024	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	1.0	35.0	34.0	-0.044	0.071	1000.0	-1000.0	-0.031	-1000.0
BARD1 signaling events	1.0	71.0	57.0	-0.051	0.077	1000.0	-1000.0	-0.036	-1000.0
Circadian rhythm pathway	1.0	36.0	22.0	-0.01	0.052	1000.0	-1000.0	-0.047	-1000.0
Ephrin A  reverse signaling	1.0	10.0	7.0	-0.0	0.034	1000.0	-1000.0	-0.001	-1000.0
Signaling events mediated by HDAC Class I	1.0	194.0	104.0	-0.047	0.085	1000.0	-1000.0	-0.025	-1000.0
Rapid glucocorticoid signaling	1.0	20.0	20.0	-0.0	0.048	1000.0	-1000.0	-0.002	-1000.0
Signaling events mediated by PRL	1.0	61.0	34.0	-0.029	0.051	1000.0	-1000.0	-0.029	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.03	0.03	1000.0	-1000.0	-0.02	-1000.0
Alternative NF-kappaB pathway	1.0	21.0	13.0	-0.0	0.081	1000.0	-1000.0	-0.0	-1000.0
Canonical NF-kappaB pathway	0.0	30.0	39.0	-0.0	0.074	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by HDAC Class II	0.0	72.0	75.0	-0.041	0.066	1000.0	-1000.0	-0.018	-1000.0
Aurora C signaling	0.0	4.0	7.0	-0.0	0.059	1000.0	-1000.0	-0.013	-1000.0
Effects of Botulinum toxin	0.0	20.0	26.0	-0.006	0.058	1000.0	-1000.0	-0.002	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	8.0	27.0	0.0	0.072	1000.0	-1000.0	-0.029	-1000.0
Arf1 pathway	0.0	39.0	54.0	-0.002	0.048	1000.0	-1000.0	-0.015	-1000.0
Total	933	58508	7203	-11.9879856955	8.24151975432	131000	-131000	-4.12198551952	-131000