E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.011 0.135 -9999.0 0.0 -0.409 51.0 51.0 KLHL20 -0.013 0.085 -9999.0 0.0 -0.193 70.0 70.0 CYFIP2 0.02 0.017 -9999.0 0.0 -0.12 8.0 8.0 Rac1/GDP 0.011 0.093 -9999.0 0.0 -0.226 57.0 57.0 ENAH -0.012 0.134 -9999.0 0.0 -0.405 52.0 52.0 AP1M1 0.021 0.017 -9999.0 0.0 -0.12 8.0 8.0 RAP1B 0.019 0.019 -9999.0 0.0 -0.121 10.0 10.0 RAP1A 0.021 0.011 -9999.0 0.0 -0.12 3.0 3.0 CTNNB1 0.022 0.007 -9999.0 0.0 -0.12 1.0 1.0 CDC42/GTP 0.009 0.071 -9999.0 0.0 -0.201 37.0 37.0 ABI1/Sra1/Nap1 -0.028 0.049 -9999.0 0.0 -0.137 74.0 74.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.038 0.055 -9999.0 0.0 -0.105 65.0 65.0 RAPGEF1 -0.002 0.115 -9999.0 0.0 -0.343 51.0 51.0 CTNND1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.012 0.137 -9999.0 0.0 -0.416 51.0 51.0 CRK -0.007 0.124 -9999.0 0.0 -0.374 51.0 51.0 E-cadherin/gamma catenin/alpha catenin 0.024 0.061 -9999.0 0.0 -0.134 63.0 63.0 alphaE/beta7 Integrin 0.026 0.034 -9999.0 0.0 -0.108 33.0 33.0 IQGAP1 0.02 0.017 -9999.0 0.0 -0.12 7.0 7.0 NCKAP1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.015 0.06 -9999.0 0.0 -0.111 88.0 88.0 DLG1 -0.012 0.136 -9999.0 0.0 -0.415 51.0 51.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.023 0.05 -9999.0 0.0 -0.154 56.0 56.0 MLLT4 0.014 0.032 -9999.0 0.0 -0.121 30.0 30.0 ARF6/GTP/NME1/Tiam1 0.018 0.057 -9999.0 0.0 -0.112 74.0 74.0 PI3K -0.029 0.065 -9999.0 0.0 -0.198 56.0 56.0 ARF6 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.017 0.054 -9999.0 0.0 -0.155 44.0 44.0 TIAM1 0.015 0.032 -9999.0 0.0 -0.121 29.0 29.0 E-cadherin(dimer)/Ca2+ 0.032 0.061 -9999.0 0.0 -0.117 71.0 71.0 AKT1 0.004 0.049 -9999.0 0.0 -0.115 55.0 55.0 PIK3R1 0.015 0.031 -9999.0 0.0 -0.12 28.0 28.0 CDH1 0.02 0.015 -9999.0 0.0 -0.12 6.0 6.0 RhoA/GDP 0.012 0.092 -9999.0 0.0 -0.225 57.0 57.0 actin cytoskeleton organization -0.008 0.064 -9999.0 0.0 -0.14 71.0 71.0 CDC42/GDP 0.012 0.092 -9999.0 0.0 -0.225 57.0 57.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.001 0.08 -9999.0 0.0 -0.192 68.0 68.0 ITGB7 0.019 0.023 -9999.0 0.0 -0.12 15.0 15.0 RAC1 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.035 0.066 -9999.0 0.0 -0.126 71.0 71.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.022 0.051 -9999.0 0.0 -0.107 68.0 68.0 mol:GDP -0.0 0.101 -9999.0 0.0 -0.263 56.0 56.0 CDC42/GTP/IQGAP1 0.017 0.044 -9999.0 0.0 -0.122 49.0 49.0 JUP 0.02 0.021 -9999.0 0.0 -0.12 12.0 12.0 p120 catenin/RhoA/GDP 0.016 0.095 -9999.0 0.0 -0.234 55.0 55.0 RAC1/GTP/IQGAP1 0.017 0.045 -9999.0 0.0 -0.114 57.0 57.0 PIP5K1C/AP1M1 0.033 0.014 -9999.0 0.0 -0.141 1.0 1.0 RHOA 0.023 0.006 -9999.0 0.0 -0.12 1.0 1.0 CDC42 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.022 0.01 -9999.0 0.0 -0.12 2.0 2.0 positive regulation of S phase of mitotic cell cycle -0.014 0.063 -9999.0 0.0 -0.119 121.0 121.0 NME1 0.016 0.029 -9999.0 0.0 -0.121 23.0 23.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.013 0.14 -9999.0 0.0 -0.419 53.0 53.0 regulation of cell-cell adhesion -0.019 0.051 -9999.0 0.0 -0.178 37.0 37.0 WASF2 -0.002 0.036 -9999.0 0.0 -0.078 70.0 70.0 Rap1/GTP 0.012 0.081 -9999.0 0.0 -0.221 38.0 38.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.04 0.064 -9999.0 0.0 -0.104 79.0 79.0 CCND1 -0.018 0.076 -9999.0 0.0 -0.145 121.0 121.0 VAV2 -0.021 0.175 -9999.0 0.0 -0.46 67.0 67.0 RAP1/GDP 0.015 0.088 -9999.0 0.0 -0.233 41.0 41.0 adherens junction assembly -0.012 0.136 -9999.0 0.0 -0.405 53.0 53.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.009 -9999.0 0.0 -0.12 2.0 2.0 PIP5K1C 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.033 0.065 -9999.0 0.0 -0.171 24.0 24.0 E-cadherin/beta catenin 0.007 0.057 -9999.0 0.0 -0.226 30.0 30.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.01 0.132 -9999.0 0.0 -0.401 51.0 51.0 PIK3CA 0.02 0.017 -9999.0 0.0 -0.12 7.0 7.0 Rac1/GTP -0.06 0.114 -9999.0 0.0 -0.321 67.0 67.0 E-cadherin/beta catenin/alpha catenin 0.025 0.06 -9999.0 0.0 -0.129 68.0 68.0 ITGAE 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.012 0.14 -9999.0 0.0 -0.426 51.0 51.0