Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.023 0.043 0.141 29.0 -9999.0 0.0 29.0 KIRREL 0.018 0.027 -9999.0 0.0 -0.121 20.0 20.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.023 0.043 -9999.0 0.0 -0.142 29.0 29.0 PLCG1 0.018 0.025 -9999.0 0.0 -0.12 18.0 18.0 ARRB2 0.022 0.013 -9999.0 0.0 -0.12 5.0 5.0 WASL 0.023 0.008 -9999.0 0.0 -0.12 2.0 2.0 Nephrin/NEPH1/podocin/CD2AP 0.036 0.056 -9999.0 0.0 -0.107 66.0 66.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.021 0.053 -9999.0 0.0 -0.142 35.0 35.0 FYN 0.014 0.034 -9999.0 0.0 -0.111 27.0 27.0 mol:Ca2+ 0.04 0.048 -9999.0 0.0 -0.108 40.0 40.0 mol:DAG 0.041 0.048 -9999.0 0.0 -0.109 40.0 40.0 NPHS2 0.022 0.014 -9999.0 0.0 -0.081 7.0 7.0 mol:IP3 0.041 0.048 -9999.0 0.0 -0.109 40.0 40.0 regulation of endocytosis 0.032 0.045 -9999.0 0.0 -0.1 29.0 29.0 Nephrin/NEPH1/podocin/Cholesterol 0.034 0.035 -9999.0 0.0 -0.099 28.0 28.0 establishment of cell polarity 0.023 0.043 -9999.0 0.0 -0.141 29.0 29.0 Nephrin/NEPH1/podocin/NCK1-2 0.049 0.054 -9999.0 0.0 -0.102 39.0 39.0 Nephrin/NEPH1/beta Arrestin2 0.033 0.046 -9999.0 0.0 -0.101 29.0 29.0 NPHS1 0.021 0.02 -9999.0 0.0 -0.101 12.0 12.0 Nephrin/NEPH1/podocin 0.026 0.045 -9999.0 0.0 -0.11 29.0 29.0 TJP1 0.021 0.01 -9999.0 0.0 -0.12 2.0 2.0 NCK1 0.02 0.019 -9999.0 0.0 -0.12 9.0 9.0 NCK2 0.023 0.006 -9999.0 0.0 -0.12 1.0 1.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.042 0.049 -9999.0 0.0 -0.109 40.0 40.0 CD2AP 0.02 0.017 -9999.0 0.0 -0.12 7.0 7.0 Nephrin/NEPH1/podocin/GRB2 0.046 0.042 -9999.0 0.0 -0.108 30.0 30.0 GRB2 0.023 0.006 -9999.0 0.0 -0.12 1.0 1.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.019 0.029 -9999.0 0.0 -0.089 26.0 26.0 cytoskeleton organization 0.022 0.047 -9999.0 0.0 -0.132 31.0 31.0 Nephrin/NEPH1 0.021 0.029 -9999.0 0.0 -0.091 29.0 29.0 Nephrin/NEPH1/ZO-1 0.027 0.055 -9999.0 0.0 -0.128 57.0 57.0