Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.084 0.188 -9999.0 0.0 -0.399 137.0 137.0 IHH -0.001 0.048 -9999.0 0.0 -0.075 143.0 143.0 SHH Np/Cholesterol/GAS1 0.022 0.029 -9999.0 0.0 -0.098 19.0 19.0 LRPAP1 0.018 0.023 -9999.0 0.0 -0.12 15.0 15.0 dorsoventral neural tube patterning -0.022 0.029 0.097 19.0 -9999.0 0.0 19.0 SMO/beta Arrestin2 -0.01 0.106 -9999.0 0.0 -0.283 10.0 10.0 SMO -0.019 0.106 -9999.0 0.0 -0.308 8.0 8.0 AKT1 -0.018 0.112 -9999.0 0.0 -0.33 40.0 40.0 ARRB2 0.022 0.013 -9999.0 0.0 -0.12 5.0 5.0 BOC 0.011 0.038 -9999.0 0.0 -0.12 44.0 44.0 ADRBK1 0.023 0.001 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.018 0.105 -9999.0 0.0 -0.304 8.0 8.0 STIL -0.017 0.082 -9999.0 0.0 -0.147 137.0 137.0 DHH N/PTCH2 0.034 0.011 -9999.0 0.0 -0.147 1.0 1.0 DHH N/PTCH1 -0.019 0.099 -9999.0 0.0 -0.178 137.0 137.0 PIK3CA 0.02 0.017 -9999.0 0.0 -0.12 7.0 7.0 DHH 0.023 0.01 -9999.0 0.0 -0.12 3.0 3.0 PTHLH -0.072 0.179 -9999.0 0.0 -0.376 137.0 137.0 determination of left/right symmetry -0.018 0.105 -9999.0 0.0 -0.304 8.0 8.0 PIK3R1 0.015 0.031 -9999.0 0.0 -0.12 28.0 28.0 skeletal system development -0.072 0.178 -9999.0 0.0 -0.374 137.0 137.0 IHH N/Hhip 0.016 0.039 -9999.0 0.0 -0.097 27.0 27.0 DHH N/Hhip 0.029 0.024 -9999.0 0.0 -0.141 1.0 1.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.018 0.105 -9999.0 0.0 -0.304 8.0 8.0 pancreas development 0.017 0.029 -9999.0 0.0 -0.12 25.0 25.0 HHAT 0.022 0.011 -9999.0 0.0 -0.12 3.0 3.0 PI3K 0.007 0.065 -9999.0 0.0 -0.127 98.0 98.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.014 0.035 -9999.0 0.0 -0.12 35.0 35.0 somite specification -0.018 0.105 -9999.0 0.0 -0.304 8.0 8.0 SHH Np/Cholesterol/PTCH1 -0.013 0.086 -9999.0 0.0 -0.152 137.0 137.0 SHH Np/Cholesterol/PTCH2 0.03 0.014 -9999.0 0.0 -0.099 5.0 5.0 SHH Np/Cholesterol/Megalin 0.007 0.039 -9999.0 0.0 -0.101 20.0 20.0 SHH 0.022 0.011 -9999.0 0.0 -0.085 5.0 5.0 catabolic process -0.033 0.109 -9999.0 0.0 -0.21 137.0 137.0 SMO/Vitamin D3 -0.01 0.097 -9999.0 0.0 -0.241 8.0 8.0 SHH Np/Cholesterol/Hhip 0.027 0.02 -9999.0 0.0 -0.098 5.0 5.0 LRP2 -0.015 0.063 -9999.0 0.0 -0.12 150.0 150.0 receptor-mediated endocytosis -0.02 0.098 -9999.0 0.0 -0.206 58.0 58.0 SHH Np/Cholesterol/BOC 0.02 0.034 -9999.0 0.0 -0.107 23.0 23.0 SHH Np/Cholesterol/CDO 0.018 0.037 -9999.0 0.0 -0.098 40.0 40.0 mesenchymal cell differentiation -0.026 0.02 0.098 5.0 -9999.0 0.0 5.0 mol:Vitamin D3 -0.012 0.088 -9999.0 0.0 -0.152 137.0 137.0 IHH N/PTCH2 0.021 0.031 -9999.0 0.0 -0.141 3.0 3.0 CDON 0.013 0.035 -9999.0 0.0 -0.12 35.0 35.0 IHH N/PTCH1 -0.028 0.114 -9999.0 0.0 -0.211 137.0 137.0 Megalin/LRPAP1 -0.01 0.065 -9999.0 0.0 -0.092 200.0 200.0 PTCH2 0.023 0.008 -9999.0 0.0 -0.12 2.0 2.0 SHH Np/Cholesterol 0.018 0.012 -9999.0 0.0 -0.103 4.0 4.0 PTCH1 -0.033 0.109 -9999.0 0.0 -0.211 137.0 137.0 HHIP 0.017 0.029 -9999.0 0.0 -0.12 25.0 25.0