Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.001 0.089 -9999.0 0.0 -0.182 90.0 90.0 epithelial cell differentiation 0.028 0.06 -9999.0 0.0 -0.116 71.0 71.0 CYFIP2 0.02 0.017 -9999.0 0.0 -0.12 8.0 8.0 ENAH 0.008 0.057 -9999.0 0.0 -0.134 54.0 54.0 EGFR 0.015 0.03 -9999.0 0.0 -0.12 25.0 25.0 EPHA2 0.02 0.021 -9999.0 0.0 -0.12 13.0 13.0 MYO6 0.009 0.058 -9999.0 0.0 -0.125 71.0 71.0 CTNNB1 0.022 0.007 -9999.0 0.0 -0.12 1.0 1.0 ABI1/Sra1/Nap1 0.03 0.05 -9999.0 0.0 -0.117 54.0 54.0 AQP5 -0.059 0.146 -9999.0 0.0 -0.32 123.0 123.0 CTNND1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.014 0.05 -9999.0 0.0 -0.106 71.0 71.0 regulation of calcium-dependent cell-cell adhesion 0.013 0.051 -9999.0 0.0 -0.107 71.0 71.0 EGF 0.02 0.021 -9999.0 0.0 -0.12 13.0 13.0 NCKAP1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.011 0.077 -9999.0 0.0 -0.27 27.0 27.0 cortical microtubule organization 0.028 0.06 -9999.0 0.0 -0.116 71.0 71.0 GO:0000145 0.007 0.046 -9999.0 0.0 -0.101 71.0 71.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.033 0.062 -9999.0 0.0 -0.117 71.0 71.0 MLLT4 0.014 0.032 -9999.0 0.0 -0.12 30.0 30.0 ARF6/GDP -0.023 0.051 -9999.0 0.0 -0.168 46.0 46.0 ARF6 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.029 0.063 -9999.0 0.0 -0.11 77.0 77.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.014 0.06 -9999.0 0.0 -0.189 32.0 32.0 PVRL2 0.019 0.023 -9999.0 0.0 -0.12 15.0 15.0 ZYX 0.01 0.055 -9999.0 0.0 -0.118 71.0 71.0 ARF6/GTP 0.034 0.064 -9999.0 0.0 -0.169 19.0 19.0 CDH1 0.021 0.015 -9999.0 0.0 -0.12 6.0 6.0 EGFR/EGFR/EGF/EGF 0.015 0.063 -9999.0 0.0 -0.179 28.0 28.0 RhoA/GDP 0.03 0.059 -9999.0 0.0 -0.106 75.0 75.0 actin cytoskeleton organization 0.007 0.06 -9999.0 0.0 -0.13 71.0 71.0 IGF-1R heterotetramer 0.013 0.031 -9999.0 0.0 -0.12 28.0 28.0 GIT1 0.022 0.013 -9999.0 0.0 -0.12 5.0 5.0 IGF1R 0.013 0.031 -9999.0 0.0 -0.12 28.0 28.0 IGF1 0.007 0.045 -9999.0 0.0 -0.12 62.0 62.0 DIAPH1 -0.022 0.204 -9999.0 0.0 -0.556 71.0 71.0 Wnt receptor signaling pathway -0.028 0.06 0.116 71.0 -9999.0 0.0 71.0 RHOA 0.023 0.006 -9999.0 0.0 -0.12 1.0 1.0 RhoA/GTP -0.022 0.05 -9999.0 0.0 -0.167 45.0 45.0 CTNNA1 0.022 0.01 -9999.0 0.0 -0.12 2.0 2.0 VCL 0.007 0.062 -9999.0 0.0 -0.132 71.0 71.0 EFNA1 0.014 0.031 -9999.0 0.0 -0.12 28.0 28.0 LPP 0.011 0.055 -9999.0 0.0 -0.111 73.0 73.0 Ephrin A1/EPHA2 0.011 0.064 -9999.0 0.0 -0.179 32.0 32.0 SEC6/SEC8 -0.021 0.05 -9999.0 0.0 -0.187 35.0 35.0 MGAT3 0.013 0.052 -9999.0 0.0 -0.108 71.0 71.0 HGF/MET -0.006 0.072 -9999.0 0.0 -0.177 48.0 48.0 HGF 0.02 0.022 -9999.0 0.0 -0.12 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.001 0.089 -9999.0 0.0 -0.183 90.0 90.0 actin cable formation 0.011 0.08 -9999.0 0.0 -0.191 52.0 52.0 KIAA1543 0.012 0.05 -9999.0 0.0 -0.105 71.0 71.0 KIFC3 0.014 0.051 -9999.0 0.0 -0.107 71.0 71.0 NCK1 0.02 0.019 -9999.0 0.0 -0.12 9.0 9.0 EXOC3 0.023 0.009 -9999.0 0.0 -0.12 2.0 2.0 ACTN1 0.012 0.058 -9999.0 0.0 -0.12 71.0 71.0 NCK1/GIT1 0.022 0.043 -9999.0 0.0 -0.141 32.0 32.0 mol:GDP 0.028 0.06 -9999.0 0.0 -0.116 71.0 71.0 EXOC4 0.023 0.007 -9999.0 0.0 -0.12 1.0 1.0 STX4 0.013 0.052 -9999.0 0.0 -0.11 71.0 71.0 PIP5K1C 0.014 0.051 -9999.0 0.0 -0.107 71.0 71.0 LIMA1 0.019 0.023 -9999.0 0.0 -0.12 14.0 14.0 ABI1 0.022 0.009 -9999.0 0.0 -0.12 2.0 2.0 ROCK1 0.01 0.061 -9999.0 0.0 -0.152 46.0 46.0 adherens junction assembly 0.021 0.059 -9999.0 0.0 -0.213 18.0 18.0 IGF-1R heterotetramer/IGF1 -0.002 0.071 -9999.0 0.0 -0.163 53.0 53.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.012 0.054 -9999.0 0.0 -0.108 89.0 89.0 MET 0.001 0.047 -9999.0 0.0 -0.12 71.0 71.0 PLEKHA7 0.013 0.053 -9999.0 0.0 -0.113 71.0 71.0 mol:GTP 0.027 0.062 -9999.0 0.0 -0.109 77.0 77.0 establishment of epithelial cell apical/basal polarity 0.012 0.063 -9999.0 0.0 -0.177 37.0 37.0 cortical actin cytoskeleton stabilization -0.001 0.089 -9999.0 0.0 -0.182 90.0 90.0 regulation of cell-cell adhesion 0.007 0.06 -9999.0 0.0 -0.13 71.0 71.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.001 0.089 -9999.0 0.0 -0.183 90.0 90.0