E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.042 0.147 -9999.0 0.0 -0.335 100.0 100.0 KLHL20 -0.016 0.101 0.199 14.0 -0.23 51.0 65.0 CYFIP2 0.038 0.012 -9999.0 0.0 0.0 47.0 47.0 Rac1/GDP -0.012 0.108 0.284 4.0 -0.259 44.0 48.0 ENAH -0.038 0.144 -9999.0 0.0 -0.332 97.0 97.0 AP1M1 0.036 0.014 -9999.0 0.0 0.0 77.0 77.0 RAP1B 0.038 0.013 -9999.0 0.0 0.0 59.0 59.0 RAP1A 0.039 0.01 -9999.0 0.0 0.0 35.0 35.0 CTNNB1 0.04 0.01 -9999.0 0.0 0.0 31.0 31.0 CDC42/GTP 0.003 0.079 0.158 4.0 -0.222 23.0 27.0 ABI1/Sra1/Nap1 -0.033 0.054 -9999.0 0.0 -0.156 64.0 64.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.068 0.068 -9999.0 0.0 -0.113 43.0 43.0 RAPGEF1 -0.035 0.129 0.28 3.0 -0.31 81.0 84.0 CTNND1 0.041 0.007 -9999.0 0.0 0.0 17.0 17.0 regulation of calcium-dependent cell-cell adhesion -0.029 0.154 -9999.0 0.0 -0.336 102.0 102.0 CRK -0.033 0.134 0.251 1.0 -0.33 79.0 80.0 E-cadherin/gamma catenin/alpha catenin 0.05 0.065 -9999.0 0.0 -0.139 42.0 42.0 alphaE/beta7 Integrin 0.05 0.038 -9999.0 0.0 -0.135 17.0 17.0 IQGAP1 0.037 0.014 -9999.0 0.0 0.0 69.0 69.0 NCKAP1 0.04 0.01 -9999.0 0.0 0.0 31.0 31.0 Rap1/GTP/I-afadin 0.043 0.066 -9999.0 0.0 -0.111 69.0 69.0 DLG1 -0.044 0.15 -9999.0 0.0 -0.339 103.0 103.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.033 0.048 -9999.0 0.0 -0.146 55.0 55.0 MLLT4 0.034 0.017 -9999.0 0.0 0.0 107.0 107.0 ARF6/GTP/NME1/Tiam1 0.045 0.062 -9999.0 0.0 -0.11 58.0 58.0 PI3K -0.04 0.063 -9999.0 0.0 -0.208 40.0 40.0 ARF6 0.041 0.008 -9999.0 0.0 0.0 19.0 19.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.038 0.052 -9999.0 0.0 -0.15 30.0 30.0 TIAM1 0.037 0.014 -9999.0 0.0 0.0 72.0 72.0 E-cadherin(dimer)/Ca2+ 0.062 0.072 -9999.0 0.0 -0.128 51.0 51.0 AKT1 -0.008 0.063 0.161 15.0 -0.16 16.0 31.0 PIK3R1 0.034 0.017 -9999.0 0.0 0.0 108.0 108.0 CDH1 0.035 0.016 -9999.0 0.0 0.0 98.0 98.0 RhoA/GDP -0.013 0.108 0.222 5.0 -0.257 47.0 52.0 actin cytoskeleton organization -0.01 0.077 0.163 15.0 -0.169 48.0 63.0 CDC42/GDP -0.012 0.108 0.281 4.0 -0.257 45.0 49.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.002 0.073 -9999.0 0.0 -0.196 55.0 55.0 ITGB7 0.039 0.011 -9999.0 0.0 0.0 40.0 40.0 RAC1 0.039 0.01 -9999.0 0.0 0.0 34.0 34.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.067 0.078 -9999.0 0.0 -0.137 51.0 51.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.046 0.056 -9999.0 0.0 -0.108 48.0 48.0 mol:GDP -0.031 0.113 0.278 4.0 -0.291 47.0 51.0 CDC42/GTP/IQGAP1 0.04 0.047 -9999.0 0.0 -0.114 42.0 42.0 JUP 0.037 0.014 -9999.0 0.0 0.0 67.0 67.0 p120 catenin/RhoA/GDP -0.001 0.116 0.238 4.0 -0.266 45.0 49.0 RAC1/GTP/IQGAP1 0.038 0.046 -9999.0 0.0 -0.113 42.0 42.0 PIP5K1C/AP1M1 0.049 0.026 -9999.0 0.0 -0.136 1.0 1.0 RHOA 0.041 0.007 -9999.0 0.0 0.0 14.0 14.0 CDC42 0.04 0.009 -9999.0 0.0 0.0 24.0 24.0 CTNNA1 0.039 0.011 -9999.0 0.0 0.0 38.0 38.0 positive regulation of S phase of mitotic cell cycle -0.016 0.059 0.122 5.0 -0.123 94.0 99.0 NME1 0.035 0.015 -9999.0 0.0 0.0 91.0 91.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.039 0.147 -9999.0 0.0 -0.347 92.0 92.0 regulation of cell-cell adhesion -0.008 0.064 -9999.0 0.0 -0.185 27.0 27.0 WASF2 -0.007 0.043 0.106 13.0 -0.095 42.0 55.0 Rap1/GTP 0.002 0.087 0.204 9.0 -0.242 24.0 33.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.071 0.083 -9999.0 0.0 -0.124 48.0 48.0 CCND1 -0.02 0.072 0.14 5.0 -0.15 95.0 100.0 VAV2 -0.051 0.216 -9999.0 0.0 -0.619 49.0 49.0 RAP1/GDP -0.0 0.098 0.244 6.0 -0.269 26.0 32.0 adherens junction assembly -0.039 0.143 -9999.0 0.0 -0.336 93.0 93.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.04 0.009 -9999.0 0.0 0.0 26.0 26.0 PIP5K1C 0.038 0.012 -9999.0 0.0 0.0 54.0 54.0 regulation of heterotypic cell-cell adhesion 0.045 0.076 0.219 5.0 -0.127 60.0 65.0 E-cadherin/beta catenin 0.007 0.042 0.147 1.0 -0.228 14.0 15.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.037 0.141 -9999.0 0.0 -0.333 92.0 92.0 PIK3CA 0.03 0.019 -9999.0 0.0 0.0 155.0 155.0 Rac1/GTP -0.057 0.132 -9999.0 0.0 -0.361 61.0 61.0 E-cadherin/beta catenin/alpha catenin 0.052 0.066 -9999.0 0.0 -0.131 48.0 48.0 ITGAE 0.039 0.01 -9999.0 0.0 0.0 37.0 37.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.03 0.157 -9999.0 0.0 -0.342 102.0 102.0