Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.065 0.175 -9999.0 0.0 -0.393 123.0 123.0 IHH 0.022 0.067 -9999.0 0.0 -0.099 128.0 128.0 SHH Np/Cholesterol/GAS1 0.027 0.027 -9999.0 0.0 -0.105 15.0 15.0 LRPAP1 0.036 0.015 -9999.0 0.0 0.0 78.0 78.0 dorsoventral neural tube patterning -0.027 0.027 0.105 15.0 -9999.0 0.0 15.0 SMO/beta Arrestin2 0.018 0.118 0.245 1.0 -0.202 99.0 100.0 SMO -0.002 0.108 -9999.0 0.0 -0.205 109.0 109.0 AKT1 -0.013 0.132 -9999.0 0.0 -0.394 36.0 36.0 ARRB2 0.039 0.011 -9999.0 0.0 0.0 44.0 44.0 BOC 0.036 0.015 -9999.0 0.0 0.0 85.0 85.0 ADRBK1 0.041 0.005 -9999.0 0.0 0.0 7.0 7.0 heart looping -0.001 0.108 0.192 3.0 -0.203 109.0 112.0 STIL 0.0 0.096 0.205 29.0 -0.172 103.0 132.0 DHH N/PTCH2 0.058 0.016 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.003 0.108 -9999.0 0.0 -0.191 127.0 127.0 PIK3CA 0.03 0.019 -9999.0 0.0 0.0 155.0 155.0 DHH 0.041 0.006 -9999.0 0.0 0.0 13.0 13.0 PTHLH -0.032 0.172 -9999.0 0.0 -0.378 106.0 106.0 determination of left/right symmetry -0.001 0.108 0.192 3.0 -0.203 109.0 112.0 PIK3R1 0.034 0.017 -9999.0 0.0 0.0 108.0 108.0 skeletal system development -0.032 0.171 -9999.0 0.0 -0.375 106.0 106.0 IHH N/Hhip 0.035 0.055 -9999.0 0.0 -0.06 120.0 120.0 DHH N/Hhip 0.054 0.022 -9999.0 0.0 -0.136 1.0 1.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.001 0.108 0.192 3.0 -0.203 109.0 112.0 pancreas development 0.038 0.013 -9999.0 0.0 0.0 56.0 56.0 HHAT 0.04 0.008 -9999.0 0.0 0.0 23.0 23.0 PI3K 0.024 0.061 -9999.0 0.0 -0.152 47.0 47.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.037 0.014 -9999.0 0.0 0.0 68.0 68.0 somite specification -0.001 0.108 0.192 3.0 -0.203 109.0 112.0 SHH Np/Cholesterol/PTCH1 -0.006 0.085 -9999.0 0.0 -0.171 108.0 108.0 SHH Np/Cholesterol/PTCH2 0.032 0.017 -9999.0 0.0 -0.105 3.0 3.0 SHH Np/Cholesterol/Megalin 0.021 0.027 -9999.0 0.0 -0.104 14.0 14.0 SHH -0.018 0.007 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.036 0.096 -9999.0 0.0 -0.211 128.0 128.0 SMO/Vitamin D3 -0.006 0.1 0.195 19.0 -0.198 106.0 125.0 SHH Np/Cholesterol/Hhip 0.03 0.019 -9999.0 0.0 -0.105 4.0 4.0 LRP2 0.03 0.019 -9999.0 0.0 0.0 162.0 162.0 receptor-mediated endocytosis 0.002 0.101 0.189 21.0 -0.183 103.0 124.0 SHH Np/Cholesterol/BOC 0.025 0.029 -9999.0 0.0 -0.11 17.0 17.0 SHH Np/Cholesterol/CDO 0.023 0.035 -9999.0 0.0 -0.105 31.0 31.0 mesenchymal cell differentiation -0.03 0.019 0.105 4.0 -9999.0 0.0 4.0 mol:Vitamin D3 -0.012 0.089 0.204 26.0 -0.172 107.0 133.0 IHH N/PTCH2 0.039 0.054 -9999.0 0.0 -0.064 3.0 3.0 CDON 0.035 0.016 -9999.0 0.0 0.0 93.0 93.0 IHH N/PTCH1 -0.02 0.107 -9999.0 0.0 -0.212 128.0 128.0 Megalin/LRPAP1 0.029 0.053 -9999.0 0.0 -0.139 37.0 37.0 PTCH2 0.04 0.009 -9999.0 0.0 0.0 27.0 27.0 SHH Np/Cholesterol 0.034 0.047 0.196 42.0 -0.099 3.0 45.0 PTCH1 -0.036 0.096 -9999.0 0.0 -0.211 128.0 128.0 HHIP 0.038 0.013 -9999.0 0.0 0.0 56.0 56.0