Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.003 0.07 -9999.0 0.0 -0.191 53.0 53.0 epithelial cell differentiation 0.056 0.069 -9999.0 0.0 -0.127 51.0 51.0 CYFIP2 0.038 0.012 -9999.0 0.0 0.0 47.0 47.0 ENAH -0.033 0.071 0.216 13.0 -0.22 4.0 17.0 EGFR 0.037 0.014 -9999.0 0.0 0.0 72.0 72.0 EPHA2 0.039 0.01 -9999.0 0.0 0.0 35.0 35.0 MYO6 -0.03 0.048 0.182 7.0 -0.212 17.0 24.0 CTNNB1 0.04 0.01 -9999.0 0.0 0.0 31.0 31.0 ABI1/Sra1/Nap1 0.061 0.059 -9999.0 0.0 -0.125 41.0 41.0 AQP5 -0.076 0.14 0.178 4.0 -0.37 97.0 101.0 CTNND1 0.041 0.007 -9999.0 0.0 0.0 17.0 17.0 mol:PI-4-5-P2 -0.03 0.043 0.18 6.0 -0.199 12.0 18.0 regulation of calcium-dependent cell-cell adhesion -0.028 0.043 0.181 6.0 -0.199 12.0 18.0 EGF 0.038 0.012 -9999.0 0.0 0.0 53.0 53.0 NCKAP1 0.04 0.01 -9999.0 0.0 0.0 31.0 31.0 AQP3 -0.024 0.058 0.178 4.0 -0.293 15.0 19.0 cortical microtubule organization 0.056 0.069 -9999.0 0.0 -0.127 51.0 51.0 GO:0000145 -0.03 0.039 0.16 6.0 -0.19 12.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.062 0.072 -9999.0 0.0 -0.128 51.0 51.0 MLLT4 0.034 0.017 -9999.0 0.0 0.0 107.0 107.0 ARF6/GDP -0.05 0.046 -9999.0 0.0 -0.195 23.0 23.0 ARF6 0.041 0.008 -9999.0 0.0 0.0 19.0 19.0 Ephrin A1/EPHA2/NCK1/GIT1 0.06 0.077 -9999.0 0.0 -0.123 61.0 61.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.017 0.048 0.198 4.0 -0.211 15.0 19.0 PVRL2 0.039 0.011 -9999.0 0.0 0.0 44.0 44.0 ZYX -0.028 0.039 0.184 5.0 -0.204 8.0 13.0 ARF6/GTP 0.066 0.083 -9999.0 0.0 -0.122 62.0 62.0 CDH1 0.035 0.016 -9999.0 0.0 0.0 98.0 98.0 EGFR/EGFR/EGF/EGF 0.037 0.075 -9999.0 0.0 -0.129 66.0 66.0 RhoA/GDP 0.056 0.072 -9999.0 0.0 -0.128 50.0 50.0 actin cytoskeleton organization -0.032 0.048 0.16 6.0 -0.234 16.0 22.0 IGF-1R heterotetramer 0.033 0.017 -9999.0 0.0 0.0 118.0 118.0 GIT1 0.04 0.009 -9999.0 0.0 0.0 27.0 27.0 IGF1R 0.033 0.017 -9999.0 0.0 0.0 118.0 118.0 IGF1 0.036 0.015 -9999.0 0.0 0.0 84.0 84.0 DIAPH1 -0.002 0.222 -9999.0 0.0 -0.572 63.0 63.0 Wnt receptor signaling pathway -0.056 0.069 0.127 51.0 -9999.0 0.0 51.0 RHOA 0.041 0.007 -9999.0 0.0 0.0 14.0 14.0 RhoA/GTP -0.049 0.045 -9999.0 0.0 -0.19 22.0 22.0 CTNNA1 0.039 0.011 -9999.0 0.0 0.0 38.0 38.0 VCL -0.033 0.049 0.162 6.0 -0.239 16.0 22.0 EFNA1 0.034 0.017 -9999.0 0.0 0.0 107.0 107.0 LPP -0.029 0.044 0.168 6.0 -0.2 14.0 20.0 Ephrin A1/EPHA2 0.032 0.077 -9999.0 0.0 -0.126 74.0 74.0 SEC6/SEC8 -0.045 0.043 -9999.0 0.0 -0.189 21.0 21.0 MGAT3 -0.029 0.044 0.183 6.0 -0.201 12.0 18.0 HGF/MET 0.016 0.087 -9999.0 0.0 -0.129 113.0 113.0 HGF 0.04 0.009 -9999.0 0.0 0.0 29.0 29.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.003 0.07 -9999.0 0.0 -0.192 53.0 53.0 actin cable formation 0.002 0.097 0.253 28.0 -0.254 14.0 42.0 KIAA1543 -0.033 0.043 0.166 6.0 -0.202 13.0 19.0 KIFC3 -0.032 0.041 0.18 5.0 -0.201 12.0 17.0 NCK1 0.036 0.015 -9999.0 0.0 0.0 80.0 80.0 EXOC3 0.041 0.005 -9999.0 0.0 0.0 8.0 8.0 ACTN1 -0.031 0.049 0.182 7.0 -0.218 16.0 23.0 NCK1/GIT1 0.044 0.047 -9999.0 0.0 -0.135 30.0 30.0 mol:GDP 0.056 0.069 -9999.0 0.0 -0.127 51.0 51.0 EXOC4 0.038 0.012 -9999.0 0.0 0.0 49.0 49.0 STX4 -0.029 0.034 -9999.0 0.0 -0.123 49.0 49.0 PIP5K1C -0.031 0.043 0.181 6.0 -0.201 12.0 18.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.04 0.009 -9999.0 0.0 0.0 26.0 26.0 ROCK1 -0.026 0.085 0.258 12.0 -0.231 4.0 16.0 adherens junction assembly -0.05 0.128 -9999.0 0.0 -0.405 42.0 42.0 IGF-1R heterotetramer/IGF1 0.023 0.083 -9999.0 0.0 -0.128 94.0 94.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.051 -9999.0 0.0 -0.14 34.0 34.0 MET 0.027 0.02 -9999.0 0.0 0.0 198.0 198.0 PLEKHA7 -0.031 0.045 0.182 7.0 -0.203 14.0 21.0 mol:GTP 0.058 0.075 -9999.0 0.0 -0.122 61.0 61.0 establishment of epithelial cell apical/basal polarity -0.038 0.056 0.136 25.0 -0.203 16.0 41.0 cortical actin cytoskeleton stabilization 0.003 0.07 -9999.0 0.0 -0.191 53.0 53.0 regulation of cell-cell adhesion -0.032 0.048 0.16 6.0 -0.234 16.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.003 0.07 -9999.0 0.0 -0.192 53.0 53.0