rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p q 1 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(66), AXIN1(1), AXIN2(2), BTRC(3), CACYBP(1), CAMK2D(1), CHD8(2), CREBBP(4), CTNNB1(4), CUL1(1), DAAM1(1), DAAM2(4), DKK1(2), DKK2(1), DKK4(3), DVL2(1), DVL3(2), EP300(2), FBXW11(1), FZD1(1), FZD10(2), FZD3(3), FZD4(1), FZD6(3), GSK3B(1), LRP6(7), MAP3K7(2), MAPK10(4), MAPK8(5), MAPK9(2), MMP7(2), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PLCB3(1), PLCB4(1), PPARD(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRICKLE1(3), PRICKLE2(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), RBX1(1), RHOA(1), ROCK1(7), ROCK2(4), RUVBL1(2), SENP2(1), SFRP1(1), SFRP2(2), SFRP4(1), SMAD2(5), SMAD3(3), SMAD4(8), TBL1X(1), TBL1Y(1), TCF7(3), TCF7L2(7), TP53(45), WNT10B(1), WNT2(1), WNT2B(2), WNT6(1), WNT8A(1), WNT9B(1) 16648987 263 68 234 35 68 67 33 3 74 18 <1.00e-15 <6.22e-14 2 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 APC(66), AXIN1(1), CTNNB1(4), FZD1(1), GJA1(4), GNAI1(1), GSK3B(1), MYD88(1), NFKB1(3), PIK3CA(7), PIK3R1(5), TLR4(3) 3101261 97 60 87 4 12 15 10 0 40 20 <1.00e-15 <6.22e-14 3 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 ATF2(1), CDC42(1), DLD(1), DUSP10(1), GCK(1), IL1R1(1), MAP2K4(2), MAP2K5(2), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K2(1), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAPK10(4), MAPK8(5), MAPK9(2), NFATC3(1), PAPPA(5), TP53(45), ZAK(2) 5206358 90 54 75 11 34 19 12 3 22 0 <1.00e-15 <6.22e-14 4 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ATM(10), ATR(4), CCNA1(2), CDK4(1), CDKN1B(2), DHFR(1), GSK3B(1), RB1(3), TGFB2(4), TP53(45) 3112957 73 51 58 11 24 18 10 2 18 1 <1.00e-15 <6.22e-14 5 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(1), ATM(10), CDK4(1), PCNA(1), RB1(3), TIMP3(1), TP53(45) 1905683 62 50 47 6 21 14 9 2 15 1 <1.00e-15 <6.22e-14 6 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(10), ATR(4), BRCA1(1), BRCA2(11), FANCA(2), FANCD2(4), FANCF(1), FANCG(2), MRE11A(5), RAD17(2), RAD50(6), TP53(45) 4587794 93 49 78 7 27 31 16 2 16 1 <1.00e-15 <6.22e-14 7 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(4), DAXX(1), PAX3(2), PML(1), RB1(3), SIRT1(1), TP53(45) 1965067 57 49 42 5 26 7 8 2 14 0 <1.00e-15 <6.22e-14 8 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CDK4(1), CDKN1B(2), PRB1(1), TP53(45) 831472 49 48 34 2 20 6 6 2 15 0 <1.00e-15 <6.22e-14 9 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(2), MAP3K14(1), NFKB1(3), TP53(45) 1059846 51 47 36 3 22 7 8 2 12 0 <1.00e-15 <6.22e-14 10 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP6(1), FAS(2), GZMB(1), MAP2K4(2), MAP3K1(2), MAP3K14(1), MAPK10(4), NFKB1(3), TP53(45), TRAF1(1) 3868503 71 49 56 8 27 12 11 2 19 0 1.11e-15 6.22e-14 11 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 APAF1(1), ATM(10), CASP3(1), CASP6(1), PRKCA(2), TLN1(2), TP53(45) 2877312 62 49 47 5 20 16 8 2 15 1 1.11e-15 6.22e-14 12 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(10), CCNA1(2), CCNE2(1), CDK4(1), CDKN1B(2), CREB3(1), CREB3L3(2), E2F3(1), MCM3(2), MCM5(3), MCM6(1), MCM7(1), MYT1(5), PCNA(1), POLE(4), POLE2(1), RB1(3), RBL1(2), TNXB(3), TP53(45) 7803479 91 53 75 16 31 25 12 3 19 1 1.33e-15 6.84e-14 13 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 SP3(1), TP53(45), WT1(2) 720183 48 46 33 2 21 7 6 2 12 0 1.44e-15 6.84e-14 14 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT2(1), AKT3(1), APC(66), AXIN1(1), AXIN2(2), CTNNB1(4), DACT1(1), DKK1(2), DKK2(1), DKK4(3), FSTL1(1), GSK3B(1), LRP1(3), SENP2(1), SFRP1(1), TSHB(1) 4183619 90 59 80 4 8 14 11 0 39 18 1.78e-15 7.49e-14 15 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(66), CDH1(1), CREBBP(4), EP300(2), MAP2K1(1), MAP3K7(2), MAPK3(1), SKIL(1), TGFB2(4), TGFBR1(3) 2676934 85 57 75 4 5 10 8 0 44 18 2.00e-15 7.49e-14 16 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ANAPC1(1), ANAPC4(3), ANAPC5(1), ATM(10), ATR(4), BUB1(2), BUB1B(3), CCNA1(2), CCNB3(3), CCNE2(1), CDC14A(3), CDC14B(1), CDC16(1), CDC25C(1), CDC27(4), CDC6(1), CDC7(1), CDK4(1), CDKN1B(2), CREBBP(4), CUL1(1), DBF4(3), E2F3(1), EP300(2), GSK3B(1), MAD1L1(1), MCM3(2), MCM5(3), MCM6(1), MCM7(1), PCNA(1), PLK1(2), PRKDC(5), RB1(3), RBL1(2), RBX1(1), SMAD2(5), SMAD3(3), SMAD4(8), SMC1B(2), TGFB2(4), TP53(45), YWHAH(1) 14262845 147 55 130 32 44 49 26 3 24 1 2.11e-15 7.49e-14 17 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BTK(1), CAD(1), CASP3(1), CASP8AP2(6), DAXX(1), DEDD(1), DFFA(1), EGFR(1), EPHB2(1), IL8(1), MAP2K4(2), MAP3K1(2), MAP3K5(1), MAPK10(4), MAPK8(5), MAPK8IP3(1), MAPK9(2), MET(1), NFKB1(3), NFKB2(2), PTPN13(9), RALBP1(2), ROCK1(7), TP53(45), TPX2(1) 7607004 102 50 87 17 34 28 17 3 20 0 2.11e-15 7.49e-14 18 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(66), CASP3(1), CREB3(1), CREB5(2), DAG1(1), EPHB2(1), FOS(1), GNAQ(1), MAP2K4(2), MAPK10(4), MAPK8(5), MAPK8IP3(1), MAPK9(2) 2881625 88 58 78 3 7 9 7 2 45 18 2.22e-15 7.49e-14 19 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(1), ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), APC(66), ARHGEF1(1), ARHGEF12(2), ARHGEF4(1), ARHGEF6(3), ARPC2(1), ARPC5L(1), BAIAP2(1), BDKRB2(1), BRAF(2), CDC42(1), CHRM2(3), CHRM4(1), CHRM5(1), CSK(2), CYFIP1(1), CYFIP2(1), DIAPH2(3), DIAPH3(2), DOCK1(2), EGFR(1), F2(1), FGD1(2), FGD3(1), FGF11(1), FGF12(1), FGF13(1), FGF19(1), FGF20(1), FGF5(2), FGFR1(1), FGFR2(5), FN1(4), GIT1(1), GRLF1(5), IQGAP1(3), IQGAP2(3), ITGA10(4), ITGA11(2), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAD(1), ITGAE(2), ITGAL(3), ITGAM(3), ITGAV(4), ITGAX(2), ITGB2(1), ITGB3(2), ITGB4(1), ITGB5(1), ITGB8(1), KRAS(38), LIMK1(1), LIMK2(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MOS(1), MSN(3), MYH10(2), MYH14(3), MYH9(3), MYL9(2), MYLK(3), MYLK2(1), NCKAP1(1), NCKAP1L(4), NRAS(5), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PDGFRA(4), PDGFRB(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PIP5K1B(1), PIP5K1C(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP1R12B(4), RAF1(2), RDX(1), RHOA(1), ROCK1(7), ROCK2(4), RRAS2(1), SCIN(1), SLC9A1(2), SOS1(2), SOS2(2), SSH1(2), SSH3(1), TIAM1(5), TIAM2(2), VAV1(2), VAV2(2), VAV3(2), VCL(1), WASF1(2), WASL(2) 29141477 332 66 291 70 74 124 38 4 72 20 2.44e-15 7.49e-14 20 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(66), AR(2), BRAF(2), DAG1(1), EGFR(1), GNAI1(1), GNAQ(1), ITPR1(8), ITPR2(6), ITPR3(1), KCNJ5(1), KCNJ9(1), MAPK10(4), PHKA2(1), PIK3CA(7), PIK3CD(1), PIK3R1(5), RAF1(2) 5604387 111 60 101 7 18 15 11 0 46 21 2.44e-15 7.49e-14 21 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(66), AXIN1(1), CREBBP(4), CTNNB1(4), EP300(2), FZD1(1), GSK3B(1), LDB1(2), TRRAP(4) 3373014 85 58 75 4 8 12 6 0 41 18 2.55e-15 7.49e-14 22 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 PIK3CA(7), PIK3R1(5), POLR1A(3), POLR1B(2), RB1(3), TP53(45) 2064912 65 53 50 5 26 11 10 2 14 2 2.78e-15 7.73e-14 23 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(10), ATR(4), CDC25C(1), TP53(45), YWHAH(1) 1657129 61 49 46 6 22 16 7 2 13 1 2.89e-15 7.73e-14 24 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(1), APC(66), AXIN1(1), BTRC(3), CTNNB1(4), DLL1(3), FZD1(1), GSK3B(1) 2052660 80 58 70 1 6 8 6 0 42 18 3.33e-15 7.84e-14 25 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT2(1), AKT3(1), BTK(1), FCER1A(1), FYN(1), GRB2(1), INPP5D(2), KRAS(38), LAT(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK9(2), MS4A2(2), NRAS(5), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLA2G4A(3), PLA2G6(2), PLCG2(4), PRKCA(2), PRKCE(2), RAF1(2), SOS1(2), SOS2(2), SYK(3), VAV1(2), VAV2(2), VAV3(2) 7464758 126 49 95 19 28 63 16 2 15 2 3.44e-15 7.84e-14 26 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL2(2), AKT2(1), AKT3(1), BRAF(2), CAMK2D(1), CBL(3), CBLB(2), CDKN1B(2), EGFR(1), ERBB2(4), ERBB3(3), ERBB4(5), GRB2(1), GSK3B(1), KRAS(38), MAP2K1(1), MAP2K2(1), MAP2K4(2), MAPK10(4), MAPK3(1), MAPK8(5), MAPK9(2), NCK1(1), NRAS(5), NRG1(6), NRG2(2), NRG3(4), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLCG2(4), PRKCA(2), PRKCG(2), RAF1(2), RPS6KB2(1), SHC2(1), SOS1(2), SOS2(2), STAT5B(1) 10697534 144 54 111 20 31 68 22 2 19 2 3.55e-15 7.84e-14 27 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(66), AXIN1(1), BTRC(3), CREBBP(4), CSNK1D(1), CTNNB1(4), FZD1(1), GSK3B(1), MAP3K7(2), PPARD(1) 3007549 84 58 74 4 8 9 8 0 41 18 3.66e-15 7.84e-14 28 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(1), AKT2(1), AKT3(1), APAF1(1), ATM(10), BIRC2(2), BIRC3(5), CAPN2(1), CASP3(1), CASP6(1), CFLAR(1), CHUK(2), DFFA(1), FAS(2), IKBKB(2), IL1B(1), IL1R1(1), IL1RAP(1), IRAK3(2), IRAK4(2), MAP3K14(1), MYD88(1), NFKB1(3), NFKB2(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACA(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), TNFRSF10B(4), TNFRSF10D(1), TP53(45) 8639211 126 54 111 21 45 34 19 2 23 3 3.66e-15 7.84e-14 29 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(10), CDC25C(1), CDK4(1), MYT1(5), RB1(3), TP53(45), YWHAH(1) 1850028 66 50 51 5 24 16 9 2 14 1 4.00e-15 7.84e-14 30 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(66), ATF2(1), AXIN1(1), BMP10(1), BMP2(1), BMP4(1), BMP5(1), BMP7(1), BMPR2(3), CTNNB1(4), FZD1(1), GSK3B(1), MAP3K7(2), MEF2C(2), NPPB(1), RFC1(4), TGFB2(4), TGFBR1(3), TGFBR3(3) 3708540 102 59 92 3 13 19 9 0 43 18 4.11e-15 7.84e-14 31 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), APC(66), CAV3(1), DAG1(1), DLG4(1), EPHB2(1), GNAI1(1), GNAQ(1), ITPR1(8), ITPR2(6), ITPR3(1), KCNJ5(1), KCNJ9(1), RHO(1), RYR1(6) 4852254 97 57 87 9 14 15 6 0 43 19 4.11e-15 7.84e-14 32 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT2(1), AKT3(1), BLNK(1), BTK(1), CARD11(3), CD22(2), CD72(1), CD79B(1), CHUK(2), CR2(2), FOS(1), GSK3B(1), IKBKB(2), INPP5D(2), KRAS(38), LILRB3(1), MALT1(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKB2(2), NRAS(5), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLCG2(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), RASGRP3(3), SYK(3), VAV1(2), VAV2(2), VAV3(2) 7707362 115 49 84 17 30 64 11 0 8 2 4.11e-15 7.84e-14 33 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(66), AXIN1(1), CTNNB1(4), DVL2(1), DVL3(2), FBXW2(1), FZD1(1), FZD10(2), FZD3(3), FZD6(3), GSK3B(1), LDLR(1), MAPK10(4), MAPK9(2), PLAU(1), PPP2R5C(1), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PRKD1(5), RHOA(1), SFRP4(1), TCF7(3), WNT10B(1), WNT2(1), WNT2B(2), WNT6(1) 6066998 117 58 107 13 15 27 8 0 49 18 4.22e-15 7.84e-14 34 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ATM(10), BRCA1(1), MAPK8(5), MRE11A(5), NFKB1(3), RAD50(6), TP53(45) 3071181 75 49 60 7 26 22 10 3 13 1 4.33e-15 7.84e-14 35 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ATM(10), BUB1(2), BUB1B(3), CCNA1(2), CCNB3(3), CCNE2(1), CDAN1(2), CDC14A(3), CDC14B(1), CDC25C(1), CDC6(1), CDC7(1), CDH1(1), CDK4(1), E2F3(1), EP300(2), GSK3B(1), HDAC5(1), HDAC6(2), MAD1L1(1), MCM3(2), MCM5(3), MCM6(1), MCM7(1), MPEG1(2), MPL(1), PCNA(1), PLK1(2), PRKDC(5), RB1(3), RBL1(2), SMAD4(8), TP53(45) 11654410 116 55 99 21 39 34 20 3 19 1 5.00e-15 8.79e-14 36 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(10), ATR(4), BRCA1(1), CDC25C(1), EP300(2), MYT1(5), PRKDC(5), TP53(45), YWHAH(1) 4494201 74 49 59 8 27 20 10 2 14 1 5.88e-15 9.84e-14 37 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(1), ATM(10), ATR(4), CASP3(1), CCNB3(3), CCNE2(1), CCNG1(1), CDK4(1), DDB2(1), EI24(1), FAS(2), GTSE1(2), IGFBP3(2), MDM4(1), PTEN(4), RFWD2(1), SERPINB5(2), SERPINE1(2), SESN2(1), SESN3(1), THBS1(2), TNFRSF10B(4), TP53(45), TP53I3(2), TSC2(1), ZMAT3(2) 6662609 98 52 83 14 35 30 13 2 17 1 6.00e-15 9.84e-14 38 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(1), BCL2L11(1), BIRC2(2), BIRC3(5), CASP3(1), CASP4(2), CASP6(1), CHUK(2), DFFA(1), FAS(2), GZMB(1), HELLS(1), IKBKB(2), IRF3(2), IRF4(2), MAP2K4(2), MAP3K1(2), MAPK10(4), NFKB1(3), TNFRSF10B(4), TNFRSF21(1), TP53(45), TRAF1(1), TRAF3(2) 5890717 90 50 75 13 35 19 12 2 22 0 6.11e-15 9.84e-14 39 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(2), CPEB1(3), EGFR(1), ERBB2(4), ERBB4(5), ETS1(1), ETS2(1), ETV6(1), FMN2(3), GRB2(1), KRAS(38), MAP2K1(1), MAPK3(1), NOTCH2(2), NOTCH3(3), NOTCH4(4), PIWIL1(3), PIWIL2(4), PIWIL3(2), PIWIL4(2), RAF1(2), SOS1(2), SOS2(2), SPIRE1(1) 5233661 89 48 57 9 13 54 13 1 8 0 6.33e-15 9.84e-14 40 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(5), ATM(10), CPB2(1), CSNK1D(1), FHL2(1), HIF1A(2), IGFBP3(2), MAPK8(5), TP53(45) 2105271 72 50 57 4 26 18 9 3 15 1 6.44e-15 9.84e-14 41 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(1), IFNGR1(1), IFNGR2(1), IKBKB(2), JAK2(3), NFKB1(3), RB1(3), TP53(45), USH1C(3), WT1(2) 1879284 64 48 49 6 25 14 7 2 15 1 6.55e-15 9.84e-14 42 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 EGFR(1), IGF1R(1), PRKCA(2), RB1(3), TERF1(1), TP53(45), XRCC5(2) 2927011 55 48 40 6 22 9 9 2 13 0 7.33e-15 1.07e-13 43 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT2(1), AKT3(1), CDC42(1), KDR(2), KRAS(38), MAP2K1(1), MAP2K2(1), MAPK13(1), MAPK3(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NRAS(5), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLA2G4A(3), PLA2G6(2), PLCG2(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), PRKCG(2), PTGS2(1), RAF1(2), SH2D2A(1), SHC2(1), SPHK1(1) 7436414 99 50 68 19 27 50 10 0 10 2 9.21e-15 1.32e-13 44 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 125 BRAF(2), CASP3(1), FAS(2), FCGR3A(1), FYN(1), GRB2(1), GZMB(1), HLA-A(2), HLA-G(1), IFNA10(2), IFNA2(1), IFNAR2(1), IFNGR1(1), IFNGR2(1), ITGAL(3), ITGB2(1), KIR3DL1(1), KIR3DL2(1), KLRC3(1), KRAS(38), LAT(1), LCK(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MICB(2), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NRAS(5), PAK1(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLCG2(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), PRKCG(2), PTPN11(3), RAF1(2), SH3BP2(1), SHC2(1), SOS1(2), SOS2(2), SYK(3), TNFRSF10B(4), TNFRSF10D(1), TYROBP(1), VAV1(2), VAV2(2), VAV3(2) 11667994 139 52 108 30 35 67 21 0 14 2 1.39e-13 1.94e-12 45 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(4), ADCY8(1), ATF4(1), BRAF(2), CACNA1C(2), CAMK2D(1), CAMK4(1), CREBBP(4), EP300(2), GNAQ(1), GRIA1(1), GRIA2(3), GRIN2A(6), GRIN2B(2), GRIN2C(2), GRIN2D(2), GRM1(3), GRM5(3), ITPR1(8), ITPR2(6), ITPR3(1), KRAS(38), MAP2K1(1), MAP2K2(1), MAPK3(1), NRAS(5), PLCB3(1), PLCB4(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), RAF1(2), RAP1A(1), RAPGEF3(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(2) 10645278 127 51 96 29 32 67 16 0 10 2 1.13e-12 1.55e-11 46 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT2(1), AKT3(1), CARD11(3), CBL(3), CBLB(2), CD28(1), CDC42(1), CDK4(1), CHUK(2), CTLA4(1), FOS(1), FYN(1), GRAP2(3), GRB2(1), IKBKB(2), IL10(1), IL2(1), ITK(3), KRAS(38), LAT(1), LCK(1), LCP2(1), MALT1(1), MAP3K14(1), NCK1(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKB2(2), NRAS(5), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCQ(1), PTPRC(8), RASGRP1(3), RHOA(1), SOS1(2), SOS2(2), TEC(2), VAV1(2), VAV2(2), VAV3(2) 10512928 145 49 114 20 41 74 17 0 11 2 1.20e-12 1.61e-11 47 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), CAMK2D(1), CREB3(1), CREB3L2(1), CREB3L3(2), CREBBP(4), CTNNB1(4), DCT(4), DVL2(1), DVL3(2), EDNRB(5), EP300(2), FZD1(1), FZD10(2), FZD3(3), FZD4(1), FZD6(3), GNAI1(1), GNAQ(1), GSK3B(1), KIT(2), KRAS(38), MAP2K1(1), MAP2K2(1), MAPK3(1), MITF(3), NRAS(5), PLCB3(1), PLCB4(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), RAF1(2), TCF7(3), TCF7L2(7), TYR(1), WNT10B(1), WNT2(1), WNT2B(2), WNT6(1), WNT8A(1), WNT9B(1) 11245962 134 52 103 35 30 79 11 1 13 0 4.03e-12 5.28e-11 48 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(2), CACNA1A(9), CRHR1(1), GNAI1(1), GNAQ(1), GRIA1(1), GRIA2(3), GRIA3(3), GRID2(2), GRM1(3), GRM5(3), GUCY1A2(4), GUCY1A3(5), GUCY1B3(2), GUCY2C(1), GUCY2D(4), GUCY2F(4), IGF1R(1), ITPR1(8), ITPR2(6), ITPR3(1), KRAS(38), MAP2K1(1), MAP2K2(1), MAPK3(1), NOS1(6), NPR2(1), NRAS(5), PLA2G4A(3), PLA2G6(2), PLCB3(1), PLCB4(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), PRKCA(2), PRKCG(2), PRKG1(5), PRKG2(2), RAF1(2), RYR1(6) 11630857 150 51 118 38 40 75 23 0 11 1 3.79e-11 4.87e-10 49 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ATF4(1), CACNA1C(2), CACNA1D(1), CACNA1F(2), CACNA1S(4), CAMK2D(1), CDC42(1), CGA(1), EGFR(1), FSHB(1), GNAQ(1), GRB2(1), ITPR1(8), ITPR2(6), ITPR3(1), KRAS(38), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K2(1), MAP3K3(1), MAP3K4(3), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK9(2), MMP2(3), NRAS(5), PLA2G4A(3), PLA2G6(2), PLCB3(1), PLCB4(1), PLD1(3), PLD2(1), PRKACA(1), PRKACG(1), PRKCA(2), RAF1(2), SOS1(2), SOS2(2) 13522233 143 53 112 25 36 69 16 2 19 1 6.87e-11 8.64e-10 50 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(2), ACVR1C(1), AKT2(1), AKT3(1), ATF2(1), ATF4(1), BRAF(2), CACNA1A(9), CACNA1B(4), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1F(2), CACNA1I(2), CACNA1S(4), CACNA2D1(3), CACNA2D3(3), CACNB2(1), CACNB3(1), CACNB4(2), CACNG2(1), CACNG3(3), CACNG6(1), CACNG7(3), CASP3(1), CDC42(1), CHUK(2), DAXX(1), DUSP10(1), DUSP16(2), DUSP5(1), DUSP6(1), DUSP7(1), ECSIT(1), EGFR(1), ELK4(1), FAS(2), FGF11(1), FGF12(1), FGF13(1), FGF19(1), FGF20(1), FGF5(2), FGFR1(1), FGFR2(5), FLNA(1), FLNB(2), FLNC(2), FOS(1), GRB2(1), IKBKB(2), IL1B(1), IL1R1(1), IL1R2(4), KRAS(38), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K5(2), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K14(1), MAP3K2(1), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(3), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK8IP3(1), MAPK9(2), MAPT(1), MEF2C(2), MKNK2(1), MOS(1), NF1(4), NFATC2(2), NFATC4(1), NFKB1(3), NFKB2(2), NRAS(5), NTRK2(1), PAK1(1), PAK2(1), PDGFRA(4), PDGFRB(1), PLA2G4A(3), PLA2G6(2), PPM1B(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PPP5C(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), PTPN7(1), PTPRR(4), RAF1(2), RAP1A(1), RAPGEF2(5), RASA1(4), RASA2(2), RASGRF1(3), RASGRF2(4), RASGRP1(3), RASGRP2(2), RASGRP3(3), RASGRP4(1), RPS6KA2(2), RPS6KA3(2), RPS6KA5(3), RPS6KA6(2), RRAS2(1), SOS1(2), SOS2(2), STMN1(1), TAOK2(1), TGFB2(4), TGFBR1(3), TP53(45), ZAK(2) 30316659 337 67 291 78 113 113 58 5 44 4 2.81e-10 3.46e-09 51 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), AKAP10(1), AKAP11(3), AKAP12(3), AKAP3(4), AKAP4(2), AKAP6(6), AKAP7(1), AKAP9(6), ARHGEF1(1), GNA14(1), GNAL(1), GNAQ(1), GNG4(1), GNGT1(1), IL18BP(2), ITPR1(8), KRAS(38), NRAS(5), PDE1A(1), PDE1B(1), PDE1C(2), PDE4B(3), PDE4D(1), PDE7B(1), PDE8B(1), PLCB3(1), PPP3CA(2), PPP3CC(1), PRKACA(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PRKD1(5), PRKD3(2), RHOA(1), SLC9A1(2), USP5(1) 12245926 140 49 108 27 27 79 15 0 18 1 1.05e-09 1.27e-08 52 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ADRB1(1), CSNK1D(1), DRD2(2), EGFR(1), GJA1(4), GJD2(1), GNAI1(1), GNAQ(1), GRB2(1), GRM1(3), GRM5(3), GUCY1A2(4), GUCY1A3(5), GUCY1B3(2), GUCY2C(1), GUCY2D(4), GUCY2F(4), HTR2A(1), HTR2C(2), ITPR1(8), ITPR2(6), ITPR3(1), KRAS(38), MAP2K1(1), MAP2K2(1), MAP2K5(2), MAP3K2(1), MAPK3(1), NPR2(1), NRAS(5), PDGFC(1), PDGFRA(4), PDGFRB(1), PLCB3(1), PLCB4(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), PRKG1(5), PRKG2(2), RAF1(2), SOS1(2), SOS2(2), TJP1(2), TUBA1B(2), TUBA1C(2), TUBA3D(1), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB2A(2), TUBB3(1), TUBB4(1), TUBB8(1) 13764288 166 52 135 35 42 86 22 0 14 2 5.17e-09 6.13e-08 53 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 130 ACACA(4), ACACB(1), AKT2(1), AKT3(1), BRAF(2), CBL(3), CBLB(2), EXOC7(1), FBP2(1), G6PC(1), G6PC2(1), GCK(1), GRB2(1), GSK3B(1), GYS1(1), GYS2(3), IKBKB(2), INPP5D(2), INSR(1), IRS1(3), IRS4(4), KRAS(38), LIPE(1), MAP2K1(1), MAP2K2(1), MAPK10(4), MAPK3(1), MAPK8(5), MAPK9(2), MKNK2(1), NRAS(5), PCK1(3), PDE3B(1), PFKM(3), PHKA1(4), PHKA2(1), PHKB(2), PHKG2(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PPP1CB(1), PPP1CC(1), PPP1R3A(5), PPP1R3C(2), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKACA(1), PRKACG(1), PRKAG2(1), PRKAG3(2), PRKAR1A(4), PRKAR2B(1), PTPN1(1), PTPRF(1), PYGM(2), RAF1(2), RAPGEF1(2), RPS6KB2(1), SHC2(1), SLC2A4(1), SOCS2(1), SOCS4(1), SORBS1(4), SOS1(2), SOS2(2), TSC1(1), TSC2(1) 16412716 177 53 146 37 48 79 25 1 22 2 6.27e-09 7.29e-08 54 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABLIM1(1), ARHGEF12(2), CDC42(1), CXCR4(1), DCC(2), DPYSL2(2), EFNA5(3), EFNB2(1), EFNB3(1), EPHA1(3), EPHA3(3), EPHA4(2), EPHA5(6), EPHA7(3), EPHA8(2), EPHB1(3), EPHB2(1), EPHB4(3), FYN(1), GNAI1(1), GSK3B(1), KRAS(38), L1CAM(2), LIMK1(1), LIMK2(1), LRRC4C(2), MAPK3(1), MET(1), NCK1(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NRAS(5), NTN1(1), NTN4(2), NTNG1(2), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PLXNA2(3), PLXNA3(1), PLXNB1(2), PLXNB3(1), PLXNC1(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), RASA1(4), RGS3(2), RHOA(1), ROBO1(9), ROBO2(3), ROBO3(3), ROCK1(7), ROCK2(4), SEMA3A(3), SEMA3C(1), SEMA3D(4), SEMA3E(4), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4D(1), SEMA4F(4), SEMA4G(1), SEMA5A(1), SEMA5B(4), SEMA6B(2), SEMA6C(1), SEMA6D(4), SLIT1(2), SLIT2(3), SLIT3(2), SRGAP1(2), SRGAP3(1), UNC5A(1), UNC5B(1), UNC5C(3) 20340957 206 59 175 37 68 87 25 2 24 0 7.24e-09 8.26e-08 55 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP3K1(2), MAPK3(1), NFKB1(3), PIK3CA(7), PIK3R1(5), RB1(3) 2044626 28 16 28 4 8 7 7 1 3 2 7.30e-07 8.17e-06 56 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(4), ARHGEF1(1), F2(1), GNAI1(1), GNAQ(1), GNGT1(1), MAP3K7(2), PIK3CA(7), PIK3R1(5), PPP1R12B(4), PRKCA(2), ROCK1(7) 2681854 36 19 36 8 9 10 8 0 7 2 2.88e-06 3.17e-05 57 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD80(1), CTLA4(1), GRB2(1), HLA-DRA(1), HLA-DRB1(1), IL2(1), ITK(3), LCK(1), PIK3CA(7), PIK3R1(5), PTPN11(3) 1299821 26 13 26 4 9 10 3 0 2 2 4.57e-06 4.93e-05 58 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), AKT2(1), AKT3(1), AMOTL1(3), ASH1L(7), CASK(1), CDC42(1), CDK4(1), CGN(1), CLDN10(2), CLDN16(1), CLDN2(1), CLDN8(2), CTNNA1(2), CTNNA2(2), CTNNB1(4), CTTN(1), EPB41L1(1), EPB41L3(3), EXOC4(3), GNAI1(1), HCLS1(1), IGSF5(2), INADL(2), KRAS(38), LLGL2(2), MAGI1(3), MAGI2(5), MAGI3(2), MLLT4(3), MPDZ(4), MYH1(7), MYH10(2), MYH11(6), MYH13(5), MYH14(3), MYH15(4), MYH2(3), MYH3(5), MYH4(1), MYH6(4), MYH7(4), MYH7B(2), MYH8(3), MYH9(3), MYL9(2), NRAS(5), PARD3(2), PARD6A(2), PARD6G(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), PPP2R3A(2), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PTEN(4), RHOA(1), RRAS2(1), SPTAN1(4), TJAP1(1), TJP1(2), ZAK(2) 20211298 201 53 169 54 59 97 20 0 24 1 1.52e-05 0.000162 59 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(4), GNAI1(1), GNGT1(1), ITGAV(4), ITGB3(2), MAPK3(1), PDGFRA(4), PIK3CA(7), PIK3R1(5), PRKCA(2), SPHK1(1) 2829344 32 18 32 9 8 11 6 0 5 2 1.76e-05 0.000183 60 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(3), HLA-A(2), KLRC3(1), LAT(1), MAP2K1(1), MAPK3(1), PAK1(1), PIK3CA(7), PIK3R1(5), SYK(3), VAV1(2) 1942672 27 14 27 2 5 8 7 0 4 3 1.87e-05 0.000192 61 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(7), PIK3R1(5), PRKCA(2), VAV1(2) 1341348 16 12 16 4 4 6 3 0 1 2 5.19e-05 0.000524 62 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 CAT(1), GH1(1), IGF1R(1), PIK3CA(7), PIK3R1(5) 1368671 15 12 15 7 4 4 4 0 1 2 6.23e-05 0.000619 63 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 GORASP1(1), MAP2K4(2), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK8IP3(1), MAPK9(2), NFKB1(3), NFKB2(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), TRAF3(2), TRAF5(2) 3373482 39 19 39 9 11 9 6 1 10 2 7.27e-05 0.000711 64 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 GRB2(1), PIK3CA(7), PIK3R1(5), PRKCA(2), SOS1(2) 1620361 17 13 17 3 4 6 4 0 1 2 8.30e-05 0.000799 65 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 FOS(1), GRB2(1), IGF1R(1), IRS1(3), MAP2K1(1), MAPK3(1), MAPK8(5), PIK3CA(7), PIK3R1(5), PTPN11(3), RAF1(2), RASA1(4), SOS1(2) 2536900 36 15 36 5 10 11 8 1 4 2 0.000164 0.00156 66 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), PAK1(1), PDGFRA(4), PIK3CA(7), PIK3R1(5), WASL(2) 1393417 23 11 23 4 6 5 7 0 3 2 0.000173 0.00161 67 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 FOS(1), GRB2(1), INSR(1), IRS1(3), MAP2K1(1), MAPK3(1), MAPK8(5), PIK3CA(7), PIK3R1(5), PTPN11(3), RAF1(2), RASA1(4), SLC2A4(1), SOS1(2) 2615617 37 15 37 3 10 11 8 1 5 2 0.000231 0.00212 68 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(4), CAMK2D(1), GRB2(1), MAPK3(1), PIK3CA(7), PIK3R1(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), RPS6KA5(3), SOS1(2) 2998620 32 17 32 4 11 10 6 0 3 2 0.000235 0.00213 69 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 AKT2(1), AKT3(1), CD40(1), CD80(1), CHUK(2), CXCL10(1), CXCL11(1), CXCL9(1), FOS(1), IFNA10(2), IFNA2(1), IFNAR2(1), IKBKB(2), IKBKE(1), IL12A(1), IL1B(1), IL6(1), IL8(1), IRAK4(2), IRF3(2), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K7(2), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK9(2), MYD88(1), NFKB1(3), NFKB2(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), TBK1(1), TICAM1(1), TLR1(3), TLR2(4), TLR3(1), TLR4(3), TLR5(1), TLR7(3), TLR8(3), TLR9(3), TRAF3(2) 9255029 99 29 99 18 27 36 19 2 12 3 0.000240 0.00213 70 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 FOS(1), FYN(1), GRB2(1), LAT(1), LCK(1), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), PIK3CA(7), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), PTPN7(1), RAF1(2), RASA1(4), SOS1(2), VAV1(2) 4924320 53 22 53 9 21 16 7 1 6 2 0.000245 0.00213 71 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 CDC42(1), CHUK(2), MAP2K1(1), MAPK3(1), NFKB1(3), PIK3CA(7), PIK3R1(5), RAF1(2), RALA(1), RALBP1(2), RHOA(1) 1997294 26 13 26 4 9 4 8 0 3 2 0.000245 0.00213 72 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 FOS(1), GRB2(1), MAP2K1(1), MAPK3(1), MAPK8(5), NGFR(1), PIK3CA(7), PIK3R1(5), RAF1(2), SOS1(2) 1966353 26 13 26 4 7 8 6 1 2 2 0.000296 0.00251 73 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(4), IGF1R(1), KIT(2), PIK3CA(7), PIK3R1(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1), YWHAH(1) 2171106 26 14 26 11 9 9 4 0 2 2 0.000298 0.00251 74 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 CDKN1B(2), GRB2(1), MAPK3(1), PDK2(1), PIK3CA(7), PIK3R1(5), PTEN(4), SOS1(2) 1990499 23 13 23 2 4 7 5 0 5 2 0.000309 0.00257 75 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 GRB2(1), IGF1R(1), IRS1(3), MAP2K1(1), MAPK3(1), PIK3CA(7), PIK3R1(5), RAF1(2), SOS1(2), YWHAH(1) 1933111 24 13 24 4 6 7 6 0 3 2 0.000331 0.00272 76 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 CHUK(2), GH1(1), NFKB1(3), PIK3CA(7), PIK3R1(5), YWHAH(1) 1471737 19 11 19 3 7 5 4 0 1 2 0.000360 0.00292 77 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ANXA1(1), GNGT1(1), NFKB1(3), NR3C1(1), PIK3CA(7), PIK3R1(5) 1832327 18 13 18 4 7 4 3 0 2 2 0.000410 0.00328 78 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CUL1(1), FBXW7(12), RB1(3) 886428 16 10 14 3 7 2 3 0 4 0 0.000416 0.00329 79 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 CDK4(1), CDKN1B(2), MAPK3(1), NFKB1(3), PAK1(1), PIK3CA(7), PIK3R1(5), RAF1(2), RB1(3) 2117749 25 13 25 5 10 3 5 0 5 2 0.000532 0.00415 80 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), FCER1A(1), FOS(1), GRB2(1), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PAK2(1), PIK3CA(7), PIK3R1(5), PLA2G4A(3), PPP3CA(2), PPP3CB(1), PPP3CC(1), RAF1(2), SOS1(2), SYK(3), VAV1(2) 4393013 49 20 49 10 17 13 7 1 9 2 0.000544 0.00419 81 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 FOS(1), GRB2(1), JAK1(1), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), PDGFRA(4), PIK3CA(7), PIK3R1(5), PRKCA(2), RAF1(2), RASA1(4), SOS1(2) 3611206 40 17 40 6 11 14 8 1 4 2 0.000598 0.00454 82 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 ATF1(1), BRAF(2), CREB3(1), CREB5(2), CREBBP(4), DAG1(1), EGR1(1), EGR2(2), FRS2(2), GNAQ(1), MAP1B(12), MAP2K4(2), MAPK10(4), MAPK3(1), MAPK8(5), MAPK8IP3(1), MAPK9(2), OPN1LW(1), PIK3C2G(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), PTPN11(3), RPS6KA3(2), TERF2IP(1) 5332624 66 21 66 16 19 24 9 2 10 2 0.000843 0.00633 83 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(5), NRG2(2), NRG3(4), PRKCA(2) 933406 14 9 14 1 4 5 1 1 3 0 0.000893 0.00663 84 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CHN1(1), LIMK1(1), MAP3K1(2), MYLK(3), NCF2(1), PAK1(1), PDGFRA(4), PIK3CA(7), PIK3R1(5), PLD1(3), PPP1R12B(4), RALBP1(2), TRIO(1), VAV1(2), WASF1(2) 3639262 39 17 39 6 11 14 8 0 4 2 0.000921 0.00674 85 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(1), ACVR1B(2), ACVRL1(1), BMPR2(3), BUB1(2), CDKL1(2), CDS1(1), CLK1(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKZ(1), INPP4A(1), INPP4B(2), INPPL1(1), MAP3K10(1), MOS(1), NEK1(2), OCRL(4), PIK3C2A(3), PIK3C2B(5), PIK3C2G(2), PIK3CA(7), PIK3CG(2), PLCB3(1), PLCB4(1), PLCD1(1), PLCG2(4), PRKACA(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PRKD1(5), PRKG1(5), RAF1(2), RPS6KA2(2), RPS6KA3(2), TGFBR1(3), VRK1(1) 11885595 99 34 99 29 31 35 20 1 12 0 0.000931 0.00674 86 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCR(1), FOS(1), GRB2(1), JAK2(3), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), PIK3CA(7), PIK3R1(5), RAF1(2), SOS1(2), STAT5B(1) 2862819 34 15 34 4 9 11 6 1 4 3 0.00116 0.00816 87 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(1), CYP11A1(2), CYP11B1(4), CYP21A2(1), HSD3B1(1), HSD3B2(1) 921900 11 10 11 2 3 5 1 0 2 0 0.00117 0.00816 88 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(1), CYP11A1(2), CYP11B1(4), CYP21A2(1), HSD3B1(1), HSD3B2(1) 921900 11 10 11 2 3 5 1 0 2 0 0.00117 0.00816 89 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 FOS(1), GRB2(1), JAK2(3), MAP2K1(1), MAPK3(1), MPL(1), PIK3CA(7), PIK3R1(5), PRKCA(2), RAF1(2), RASA1(4), SOS1(2), STAT5B(1), THPO(1) 3113159 32 15 32 3 8 11 6 0 4 3 0.00118 0.00816 90 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGFR(1), FOS(1), GRB2(1), JAK1(1), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), PIK3CA(7), PIK3R1(5), PRKCA(2), RAF1(2), RASA1(4), SOS1(2) 3884272 37 17 37 4 11 12 7 1 4 2 0.00122 0.00838 91 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 CXCR4(1), GNAI1(1), GNAQ(1), GNGT1(1), MAP2K1(1), MAPK3(1), NFKB1(3), PIK3C2G(2), PIK3CA(7), PIK3R1(5), PRKCA(2), RAF1(2) 2915741 27 15 27 6 9 8 5 0 3 2 0.00143 0.00959 92 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4A2(1), EIF4G1(1), EIF4G3(3), IRS1(3), MAPK3(1), PDK2(1), PIK3CA(7), PIK3R1(5), PRKCA(2), PTEN(4) 2896418 28 14 28 6 7 7 6 1 5 2 0.00143 0.00959 93 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 GSK3B(1), IGF1R(1), INPPL1(1), PDK2(1), PIK3CA(7), PIK3R1(5), PTEN(4) 2050854 20 12 20 5 4 7 4 0 3 2 0.00148 0.00978 94 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(1), AGT(1), CALR(1), CAMK1(2), CAMK1G(2), CAMK4(1), CREBBP(4), F2(1), GSK3B(1), HAND1(1), HAND2(1), MAP2K1(1), MAPK3(1), MAPK8(5), MEF2C(2), MYH2(3), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PIK3CA(7), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), RAF1(2) 5194737 57 21 57 15 23 17 6 1 8 2 0.00161 0.0106 95 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1(1), ACVR1B(2), ACVR1C(1), ACVR2A(1), ACVR2B(1), ACVRL1(1), BMP2(1), BMP4(1), BMP5(1), BMP7(1), BMPR1B(1), BMPR2(3), CREBBP(4), CUL1(1), DCN(1), EP300(2), FST(1), GDF5(1), GDF6(1), INHBA(2), INHBC(1), INHBE(1), LTBP1(1), MAPK3(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), RBL1(2), RBX1(1), RHOA(1), ROCK1(7), ROCK2(4), RPS6KB2(1), SMAD2(5), SMAD3(3), SMAD4(8), SMAD5(1), SMAD9(1), SMURF1(2), TGFB2(4), TGFBR1(3), THBS1(2), THBS2(5), THBS3(1), THBS4(1), ZFYVE16(3), ZFYVE9(4) 10279890 97 32 94 16 31 36 17 0 12 1 0.00177 0.0115 96 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 CHRNG(1), MUSK(2), PIK3CA(7), PIK3R1(5), YWHAH(1) 1733217 16 11 16 3 4 5 3 0 2 2 0.00192 0.0123 97 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 GRB2(1), MAPK3(1), MEF2A(1), MEF2C(2), PIK3CA(7), PIK3R1(5) 2025915 17 12 17 3 4 5 3 0 3 2 0.00195 0.0124 98 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(1), CAD(1), CTPS(1), DCK(1), DHODH(1), DPYD(6), DPYS(1), DTYMK(1), ENTPD5(1), ENTPD6(1), NME6(1), NME7(2), NT5C1B(1), NT5C2(1), NT5E(1), PNPT1(5), POLA1(3), POLE(4), POLE2(1), POLR1A(3), POLR1B(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(5), POLR3K(1), PRIM2(3), RFC5(1), RRM1(1), TK2(1), TXNRD1(1), TXNRD2(1), TYMS(1), UMPS(1), UPB1(2), UPP2(1), UPRT(1) 8537733 67 28 65 15 18 26 10 0 13 0 0.00266 0.0167 99 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(4), FHL5(3), FSHB(1), FSHR(1), XPO1(1) 969112 10 9 10 4 4 1 3 1 1 0 0.00414 0.0258 100 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), ARHGAP5(3), CDC42(1), CLDN10(2), CLDN16(1), CLDN2(1), CLDN8(2), CTNNA1(2), CTNNA2(2), CTNNB1(4), CTNND1(1), CXCR4(1), CYBB(1), GNAI1(1), GRLF1(5), ITGA4(5), ITGAL(3), ITGAM(3), ITGB2(1), ITK(3), MAPK13(1), MLLT4(3), MMP2(3), MMP9(5), MSN(3), MYL9(2), NCF2(1), NCF4(1), NOX3(3), PECAM1(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLCG2(4), PRKCA(2), PRKCG(2), PTPN11(3), RAP1A(1), RAPGEF3(1), RHOA(1), ROCK1(7), ROCK2(4), TXK(1), VAV1(2), VAV2(2), VAV3(2), VCAM1(2), VCL(1) 13011555 124 35 124 34 48 47 18 0 9 2 0.00578 0.0356 101 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 CABIN1(2), CAMK1(2), CAMK1G(2), HDAC5(1), IGF1R(1), INSR(1), MAP2K6(1), MEF2A(1), MEF2C(2), NFATC1(1), NFATC2(2), PIK3CA(7), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(1), YWHAH(1) 3567301 33 16 33 12 11 11 3 0 6 2 0.00618 0.0377 102 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(4), GNGT1(1), PRKACA(1), PRKAR1A(4) 661717 10 8 10 1 3 4 1 0 2 0 0.00626 0.0378 103 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(4) 74796 4 3 4 0 3 1 0 0 0 0 0.00839 0.0502 104 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), GAD1(2), HDC(5), TPH1(2) 608603 10 7 10 2 3 5 1 0 1 0 0.00868 0.0514 105 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT2(1), AKT3(1), GRB2(1), GSK3B(1), IRS1(3), JAK1(1), JAK3(2), MAP4K1(1), MAPK3(1), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), PPP1R13B(1), RAF1(2), SOS1(2), SOS2(2) 3689258 34 15 34 5 9 11 7 0 5 2 0.00882 0.0517 106 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4A2(1), EIF4B(1), EIF4G1(1), EIF4G3(3), PDK2(1), PIK3CA(7), PIK3R1(5), PTEN(4), TSC1(1), TSC2(1) 2837567 25 12 25 5 7 6 5 1 4 2 0.0100 0.0583 107 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), AKR1D1(1), CYP11B1(4), CYP19A1(3), HSD17B2(1), HSD17B3(1), HSD3B1(1), HSD3B2(1), LCMT1(2), METTL2B(1), METTL6(3), PRMT3(1), PRMT7(1), PRMT8(2), SRD5A2(1), STS(1), SULT1E1(1), SULT2A1(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2) 4975748 42 18 42 9 9 19 6 1 7 0 0.0113 0.0648 108 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 CBL(3), CFLAR(1), FOS(1), GRB2(1), IL2RB(1), IRS1(3), JAK1(1), JAK3(2), MAPK3(1), NMI(1), PIK3CA(7), PIK3R1(5), RAF1(2), SOS1(2), STAT5B(1), SYK(3) 3714369 35 15 35 7 9 12 5 0 7 2 0.0116 0.0662 109 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(1), INPP4B(2), INPPL1(1), OCRL(4), PIK3C2A(3), PIK3C2B(5), PIK3C2G(2), PIK3CA(7), PIK3CG(2), PLCB3(1), PLCB4(1), PLCD1(1), PLCG2(4) 4701827 34 18 34 11 10 13 8 0 3 0 0.0119 0.0675 110 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), GRB2(1), INSR(1), IRS1(3), JAK2(3), MAP2K1(1), MAPK3(1), PIK3CA(7), PIK3R1(5), PRKCA(2), RAF1(2), SLC2A4(1), SOS1(2), STAT5B(1) 3410343 31 14 31 5 8 9 6 0 5 3 0.0126 0.0703 111 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(1), EIF2B2(1), FLT1(3), FLT4(1), HIF1A(2), KDR(2), PIK3CA(7), PIK3R1(5), PRKCA(2), VHL(1) 3473336 25 14 25 7 8 6 6 0 3 2 0.0128 0.0710 112 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), ACVR1B(2), ACVR1C(1), BAIAP2(1), CDC42(1), CDH1(1), CREBBP(4), CTNNA1(2), CTNNA2(2), CTNNB1(4), CTNND1(1), EGFR(1), EP300(2), ERBB2(4), FER(2), FGFR1(1), FYN(1), IGF1R(1), INSR(1), IQGAP1(3), LMO7(1), MAP3K7(2), MAPK3(1), MET(1), MLLT4(3), PARD3(2), PTPN1(1), PTPRF(1), PTPRJ(1), PTPRM(8), PVRL1(2), PVRL2(1), PVRL3(1), RHOA(1), SMAD2(5), SMAD3(3), SMAD4(8), SNAI2(1), SORBS1(4), SSX2IP(1), TCF7(3), TCF7L2(7), TGFBR1(3), TJP1(2), VCL(1), WASF1(2), WASF3(2), WASL(2) 12454001 110 33 106 24 40 44 13 0 12 1 0.0133 0.0730 113 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(3), FYN(1), MAP2K1(1), MAPK3(1), MYLK(3), PIK3CA(7), PIK3R1(5), RAF1(2), ROCK1(7), TLN1(2) 3933767 32 14 32 6 9 10 8 0 3 2 0.0149 0.0815 114 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(4), EP300(2), FYN(1), IL7(1), IL7R(1), JAK1(1), JAK3(2), LCK(1), NMI(1), PIK3CA(7), PIK3R1(5), STAT5B(1) 2926243 27 12 27 6 7 13 3 0 2 2 0.0167 0.0903 115 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT2(1), AKT3(1), GRB2(1), MAPK3(1), PDK1(2), PIK3CA(7), PIK3CD(1), PTEN(4), SOS1(2) 2109052 20 11 20 5 4 7 6 0 3 0 0.0204 0.109 116 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 ATF1(1), CDC42(1), CREB3(1), CREB5(2), DUSP10(1), EEF2K(1), IL1R1(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K10(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAPK13(1), MKNK2(1), NFKB1(3) 3476951 27 14 27 5 10 8 3 2 4 0 0.0206 0.109 117 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), ACTR3(1), DAG1(1), ETFA(1), ITGA9(2), ITPR1(8), ITPR2(6), ITPR3(1), MAP2K1(1), MAPK3(1), NR1I3(1), PAK1(1), PDE3B(1), PI3(1), PIK3C2G(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), RPS4X(1), SGCB(4) 5154648 47 17 47 7 14 15 8 0 6 4 0.0234 0.123 118 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT2(1), AKT3(1), GRB2(1), MAP2K1(1), MAP2K2(1), NGFR(1), PIK3CA(7), PIK3CD(1), SOS1(2) 1691548 16 9 16 4 3 7 6 0 0 0 0.0253 0.132 119 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(1), DOCK1(2), FOS(1), GRB2(1), HGF(3), MAP2K1(1), MAP2K2(1), MAP4K1(1), MAPK3(1), MAPK8(5), MET(1), PAK1(1), PIK3CA(7), PIK3R1(5), PTEN(4), PTPN11(3), RAF1(2), RAP1A(1), RASA1(4), SOS1(2) 4703951 47 15 47 8 14 14 11 1 5 2 0.0258 0.134 120 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CHUK(2), CRADD(1), IKBKB(2), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP4K2(1), MAPK8(5), NFKB1(3), TANK(3) 2520680 28 11 28 7 9 10 6 2 1 0 0.0290 0.149 121 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(3), FYN(1), LRP8(3), RELN(9), VLDLR(2) 1442622 18 8 18 5 4 8 3 1 2 0 0.0308 0.157 122 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(1), ANXA6(1), CYP11A1(2), EDNRB(5), PLA2G4A(3), PRL(1), PTGDR(1), PTGFR(1), PTGIS(1), PTGS1(2), PTGS2(1) 2134737 19 11 19 5 8 6 3 0 2 0 0.0314 0.158 123 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), IL6R(1), JAK1(1), JAK2(3), JAK3(2), PTPRU(6), REG1A(2) 1607046 16 10 16 4 10 3 0 0 2 1 0.0316 0.158 124 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(1), JAK2(3), JAK3(2), PIAS1(1), PTPRU(6), REG1A(2) 1456819 15 9 15 2 8 3 1 0 2 1 0.0317 0.158 125 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(3), ADORA2A(2), LTB4R(1), P2RY1(3), P2RY2(1), P2RY6(1) 576046 11 6 11 0 5 5 1 0 0 0 0.0330 0.163 126 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 CADM3(2), CD22(2), CD226(2), CD274(1), CD28(1), CD40(1), CD58(1), CD80(1), CDH1(1), CDH15(1), CDH2(6), CDH3(2), CDH4(4), CLDN10(2), CLDN16(1), CLDN2(1), CLDN8(2), CNTN1(5), CNTN2(2), CNTNAP1(1), CNTNAP2(4), CTLA4(1), HLA-A(2), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-F(1), HLA-G(1), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAL(3), ITGAM(3), ITGAV(4), ITGB2(1), ITGB8(1), L1CAM(2), MAG(2), NCAM1(4), NCAM2(7), NEO1(2), NFASC(4), NLGN1(3), NLGN2(1), NRCAM(1), NRXN1(3), NRXN2(1), NRXN3(2), PECAM1(1), PTPRC(8), PTPRF(1), PTPRM(8), PVRL1(2), PVRL2(1), PVRL3(1), SDC1(1), SDC2(1), SDC3(1), SELE(2), SELL(3), SELP(2), SELPLG(1), SIGLEC1(2), SPN(1), VCAM1(2), VCAN(13) 15162025 163 35 163 47 48 70 23 3 19 0 0.0342 0.167 127 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), ARHGEF1(1), GNAQ(1), GNGT1(1), MYLK(3), PPP1R12B(4), PRKCA(2), ROCK1(7) 2157851 22 10 22 5 6 7 4 0 5 0 0.0394 0.191 128 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNGR1(1), JAK1(1), JAK2(3), PTPRU(6), REG1A(2) 1196690 13 8 13 2 9 2 0 0 1 1 0.0403 0.194 129 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(3), ADORA2A(2), ADRA1B(1), ADRB1(1), AGTR1(2), AGTR2(1), AVPR1A(1), BDKRB2(1), BRS3(2), C3AR1(2), CCBP2(5), CCKAR(1), CCKBR(2), CCR3(1), CCR4(1), CCR7(2), CCR9(2), CCRL1(3), CHML(1), CHRM2(3), CHRM4(1), CHRM5(1), CNR1(2), CX3CR1(1), CXCR4(1), DRD2(2), DRD5(4), EDNRB(5), F2RL1(1), F2RL2(1), FSHR(1), GALR1(1), GPR174(1), GPR37(1), GPR6(1), GPR63(2), GPR77(1), GPR87(1), HTR1A(2), HTR1B(2), HTR1E(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(3), HTR7(1), LTB4R(1), MAS1(1), MC4R(1), MC5R(2), NMUR2(3), NPY5R(1), NTSR2(1), OPRM1(2), OR12D3(3), OR1C1(2), OR2H1(1), OR5V1(1), OR8B8(1), OXTR(1), P2RY1(3), P2RY10(1), P2RY12(1), P2RY14(2), P2RY2(1), P2RY6(1), PPYR1(3), PTGDR(1), PTGFR(1), RGR(1), RHO(1), RRH(2), SSTR1(1), SSTR2(1), SSTR4(2), SUCNR1(2), TRHR(2) 12213019 126 34 127 42 44 50 24 2 6 0 0.0430 0.205 130 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDKN1B(2), CUL1(1), NEDD8(1), RB1(3), RBX1(1) 902254 8 6 8 4 3 0 1 0 4 0 0.0460 0.218 131 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 MAP2K3(4), NFATC1(1), NFATC2(2), PRKACG(1), PRKAR1A(4), PRKAR2B(1) 1181028 13 8 13 4 6 4 1 1 1 0 0.0467 0.219 132 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(1), ANAPC4(3), ANAPC5(1), BTRC(3), CDC16(1), CDC27(4), CUL1(1), CUL2(1), FBXW11(1), FBXW7(12), RBX1(1), SMURF1(2), UBA1(1), UBE2D3(1), UBE2E2(1), VHL(1), WWP1(3) 4210629 38 15 36 12 14 11 7 0 6 0 0.0470 0.219 133 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(4), CAP1(1), CDC25C(1), GNAI1(1), GNGT1(1), MAPK3(1), MYT1(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1) 2102799 21 11 21 4 8 9 2 0 2 0 0.0506 0.234 134 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(1) 546767 6 5 6 4 2 2 1 0 1 0 0.0539 0.248 135 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(4), FOS(1), GNAI1(1), GNAQ(1), GNGT1(1), MAP2K1(1), MAPK3(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), RAF1(2), RPS6KA3(2) 3536984 31 15 31 8 15 9 2 0 5 0 0.0544 0.248 136 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT2(1), AKT3(1), BRAF(2), EIF4B(1), FIGF(2), HIF1A(2), MAPK3(1), PGF(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PRKAA1(1), PRKAA2(3), RICTOR(3), RPS6KA2(2), RPS6KA3(2), RPS6KA6(2), RPS6KB2(1), TSC1(1), TSC2(1), ULK1(1), VEGFC(3) 5451426 50 16 50 12 17 14 9 0 8 2 0.0555 0.251 137 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(1), CALCR(2), CALCRL(1), CD97(2), CRHR1(1), CRHR2(1), ELTD1(2), EMR1(3), EMR2(4), GLP1R(5), GLP2R(2), GPR64(1), LPHN2(3), LPHN3(7), VIPR1(1) 2878193 36 13 36 11 15 14 5 0 2 0 0.0563 0.253 138 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 CREBBP(4), EP300(2), MAPK3(1), ME1(2), NCOA1(2), NCOR1(5), NR2F1(1), NRIP1(1), PIK3CA(7), PIK3R1(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PTGS2(1), RB1(3), STAT5B(1) 6436610 43 18 43 13 18 12 6 0 5 2 0.0593 0.261 139 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(2), DBH(1), GAD1(2), HDC(5), MAOA(1), TPH1(2) 1486949 13 9 13 6 3 6 2 0 2 0 0.0594 0.261 140 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 JAK1(1), PTPRU(6), REG1A(2), STAT2(2) 1303088 11 8 11 2 9 1 0 0 1 0 0.0600 0.261 141 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH3B1(1), AOX1(3), DBH(1), DCT(4), ESCO1(4), ESCO2(1), FAH(1), GOT1(1), HGD(1), HPD(1), LCMT1(2), MAOA(1), MAOB(1), METTL2B(1), METTL6(3), MYST3(5), MYST4(5), PRMT3(1), PRMT7(1), PRMT8(2), SH3GLB1(1), TAT(2), TPO(3), TYR(1) 6105915 54 18 54 18 11 25 9 1 8 0 0.0602 0.261 142 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(2), AGTR2(1), ATP8A1(5), AVPR1A(1), BDKRB2(1), BRS3(2), C3AR1(2), CCKAR(1), CCKBR(2), CCR3(1), CCR4(1), CCR7(2), CX3CR1(1), CXCR4(1), EDNRB(5), FSHR(1), GALR1(1), GPR77(1), MC2R(3), MC4R(1), MC5R(2), NPY5R(1), NTSR2(1), OPRM1(2), OXTR(1), PPYR1(3), SSTR1(1), SSTR2(1), SSTR4(2), TACR3(3), TRHR(2), TSHR(1) 5248433 55 19 55 21 22 18 11 1 3 0 0.0602 0.261 143 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(3), BDKRB2(1), C1R(1), C1S(3), C2(4), C3(1), C3AR1(2), C4BPA(5), C5(4), C5AR1(1), C6(3), C7(3), C8A(3), C8B(1), C9(1), CD46(1), CD55(1), CFB(2), CFH(6), CPB2(1), CR1(3), CR2(2), F13A1(2), F13B(2), F2(1), F3(1), F5(7), F7(1), F8(3), FGA(2), FGB(1), KLKB1(2), KNG1(1), MASP1(3), PLAT(1), PLAU(1), PLAUR(1), PLG(2), PROS1(3), SERPINA1(3), SERPINA5(1), SERPIND1(1), SERPINE1(2), SERPING1(2), TFPI(3), VWF(5) 9353473 103 25 103 27 27 41 22 0 13 0 0.0605 0.261 144 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT2(1), AKT3(1), BTK(1), DAPP1(1), GRB2(1), GSK3B(1), IARS(1), INPP5D(2), PDK1(2), PIK3CA(7), PPP1R13B(1), PTEN(4), RPS6KA2(2), RPS6KA3(2), SOS1(2), SOS2(2), TEC(2), YWHAH(1) 3741619 34 14 34 8 8 13 10 0 3 0 0.0628 0.268 145 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(1) 188288 2 2 2 1 1 0 1 0 0 0 0.0634 0.269 146 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(2), GABBR1(2), GPRC5B(1), GPRC5C(1), GRM1(3), GRM2(1), GRM3(2), GRM5(3), GRM7(4), GRM8(2) 2076832 21 11 21 11 6 10 2 0 3 0 0.0648 0.273 147 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ALDH7A1(2), ASPA(2), HAL(1), HARS2(2), HDC(5), LCMT1(2), MAOA(1), MAOB(1), METTL2B(1), METTL6(3), PRMT3(1), PRMT7(1), PRMT8(2), PRPS1(1), UROC1(2) 4102334 32 15 32 13 11 13 3 1 4 0 0.0671 0.281 148 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(1), C5(4), C6(3), C7(3), C8A(3), C9(1) 1334406 15 7 15 3 4 6 2 0 3 0 0.0729 0.301 149 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM17(1), ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), CASP3(1), CDC42(1), CHUK(2), CSK(2), EGFR(1), GIT1(1), IGSF5(2), IKBKB(2), IL8(1), MAP2K4(2), MAP3K14(1), MAPK10(4), MAPK13(1), MAPK8(5), MAPK9(2), MET(1), NFKB1(3), NFKB2(2), NOD1(1), PAK1(1), PLCG2(4), PTPN11(3), PTPRZ1(5), TJP1(2) 7329270 65 21 65 11 20 23 11 1 9 1 0.0730 0.301 150 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(2), AGPAT1(1), AGPAT4(2), AGPAT6(1), CDS1(1), CHKA(2), CHPT1(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKI(4), DGKZ(1), ESCO1(4), ESCO2(1), ETNK2(1), GNPAT(1), GPAM(1), GPD1L(1), GPD2(1), MYST3(5), MYST4(5), PCYT1A(1), PISD(2), PLA2G4A(3), PLA2G6(2), PLD1(3), PLD2(1), PTDSS1(3), SH3GLB1(1) 6844399 63 21 63 17 23 19 13 0 8 0 0.0733 0.301 151 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(1), DPYD(6), DPYS(1), ENPP3(1), PANK3(1), PPCS(1), UPB1(2) 1419292 13 7 13 6 3 7 1 0 2 0 0.0738 0.301 152 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(4), GNGT1(1), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKACG(1), PRKAG2(1), PRKAR1A(4), PRKAR2B(1) 1563078 17 9 17 3 10 5 1 0 1 0 0.0775 0.314 153 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN2(1), ACTN3(1), CSK(2), CTNNA1(2), CTNNA2(2), CTNNB1(4), PECAM1(1), VCL(1) 2092613 16 11 16 4 8 6 2 0 0 0 0.0783 0.315 154 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 GNAQ(1), GRB2(1), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), PAK1(1), PRKCA(2), RAF1(2), SOS1(2) 2950645 25 11 25 5 6 8 6 2 3 0 0.0811 0.321 155 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(10), BMPR1B(1), CDK4(1), CDKN1B(2), DAZL(1), DMC1(1), EGR1(1), FSHR(1), MLH1(3), MSH5(1), NCOR1(5), NRIP1(1), PRLR(2), VDR(1), ZP2(1) 3583059 32 12 32 9 7 11 6 1 6 1 0.0815 0.321 156 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(1), ADORA1(3), ADORA2A(2), ADRA1B(1), ADRA2B(1), ADRB1(1), AGTR1(2), AGTR2(1), AVPR1A(1), BDKRB2(1), BRS3(2), C3AR1(2), C5AR1(1), CALCR(2), CALCRL(1), CCKAR(1), CCKBR(2), CGA(1), CHRM2(3), CHRM4(1), CHRM5(1), CNR1(2), CRHR1(1), CRHR2(1), CTSG(1), CYSLTR2(1), DRD2(2), DRD5(4), EDNRB(5), F2(1), F2RL1(1), F2RL2(1), FSHB(1), FSHR(1), GABBR1(2), GABBR2(4), GABRA1(2), GABRA2(3), GABRA3(1), GABRA4(2), GABRA5(1), GABRA6(1), GABRB1(1), GABRB2(3), GABRB3(4), GABRG1(2), GABRG2(3), GABRP(2), GABRQ(1), GABRR2(1), GALR1(1), GH1(1), GH2(2), GLP1R(5), GLP2R(2), GLRA2(1), GLRA3(1), GLRB(1), GPR156(2), GPR63(2), GRIA1(1), GRIA2(3), GRIA3(3), GRIA4(7), GRID1(1), GRID2(2), GRIK2(4), GRIK3(4), GRIK4(1), GRIK5(1), GRIN2A(6), GRIN2B(2), GRIN2C(2), GRIN2D(2), GRIN3A(3), GRM1(3), GRM2(1), GRM3(2), GRM5(3), GRM6(1), GRM7(4), GRM8(2), GZMA(1), HTR1A(2), HTR1B(2), HTR1E(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(3), HTR7(1), LEPR(4), LTB4R(1), MAS1(1), MC2R(3), MC4R(1), MC5R(2), MCHR2(1), NMUR2(3), NPFFR2(1), NPY5R(1), NR3C1(1), NTSR2(1), OPRM1(2), OXTR(1), P2RX2(1), P2RX4(1), P2RX7(1), P2RY1(3), P2RY10(1), P2RY14(2), P2RY2(1), P2RY6(1), PARD3(2), PPYR1(3), PRL(1), PRLR(2), PTGDR(1), PTGER3(1), PTGFR(1), PTH2R(1), RXFP1(1), RXFP2(2), SSTR1(1), SSTR2(1), SSTR4(2), TAAR1(1), TAAR5(1), TAAR6(3), TAAR8(1), TAAR9(2), TACR3(3), TRHR(2), TRPV1(1), TSHB(1), TSHR(1), VIPR1(1) 22712255 247 45 246 98 94 92 39 3 18 1 0.0816 0.321 157 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 COASY(1), DPYD(6), DPYS(1), ENPP3(1), PANK3(1), PPCS(1), UPB1(2), VNN1(1) 1778864 14 8 14 8 3 8 1 0 2 0 0.0821 0.321 158 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1R(1), C1S(3), C2(4), C3(1), C5(4), C6(3), C7(3), C8A(3), C8B(1), C9(1), MASP1(3) 2165174 27 10 27 5 9 11 4 0 3 0 0.0822 0.321 159 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 146 AKT2(1), AKT3(1), CBL(3), CBLB(2), CREBBP(4), CSF3R(1), EP300(2), GH1(1), GH2(2), GRB2(1), IFNA10(2), IFNA2(1), IFNAR2(1), IFNGR1(1), IFNGR2(1), IFNK(1), IL10(1), IL10RA(1), IL10RB(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL13RA2(1), IL2(1), IL20(1), IL20RA(1), IL21R(2), IL23R(1), IL2RB(1), IL5RA(2), IL6(1), IL6R(1), IL6ST(1), IL7(1), IL7R(1), IL9(1), JAK1(1), JAK2(3), JAK3(2), LEPR(4), LIFR(5), MPL(1), OSMR(2), PIAS1(1), PIAS2(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PRL(1), PRLR(2), PTPN11(3), SOCS2(1), SOCS4(1), SOCS5(2), SOS1(2), SOS2(2), SPRED1(1), SPRED2(1), SPRY1(1), STAM(1), STAT2(2), STAT4(3), STAT5B(1), TPO(3) 14712674 113 30 113 39 28 51 16 1 14 3 0.0831 0.322 160 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 BHMT(2), CBS(1), CTH(1), DNMT1(7), DNMT3A(2), DNMT3B(5), MARS(3), MARS2(1), MAT2B(1), MTR(1) 1814576 24 9 24 5 11 8 1 1 3 0 0.0838 0.323 161 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHKA(2), PCYT1A(1), PDHA1(1), PDHA2(2) 733253 8 6 8 4 1 2 4 0 1 0 0.0847 0.324 162 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT2(1), AKT3(1), GRB2(1), IARS(1), IL13RA1(1), INPP5D(2), JAK1(1), JAK2(3), JAK3(2), PI3(1), PIK3CA(7), PPP1R13B(1), SERPINA4(3), SOS1(2), SOS2(2) 3847568 29 13 29 2 6 12 7 0 3 1 0.0874 0.332 163 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1R(1), C1S(3), C2(4), C3(1), C5(4), C6(3), C7(3), C8A(3), C9(1), MASP1(3) 2227705 26 10 26 6 9 10 4 0 3 0 0.0945 0.357 164 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(2), CREB3(1), CREB5(2), RAF1(2), SNX13(3), TERF2IP(1) 1212148 11 5 11 1 5 2 3 1 0 0 0.0962 0.361 165 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CDS1(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKI(4), DGKZ(1), INPP4A(1), INPP4B(2), INPP5D(2), INPPL1(1), ITPR1(8), ITPR2(6), ITPR3(1), OCRL(4), PI4KA(4), PIK3C2A(3), PIK3C2B(5), PIK3C2G(2), PIK3C3(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PIP5K1B(1), PIP5K1C(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCE1(2), PLCG2(4), PLCZ1(1), PRKCA(2), PRKCG(2), PTEN(4), SYNJ1(3), SYNJ2(1) 13155650 102 29 102 26 38 36 13 0 12 3 0.102 0.380 166 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(2), DAXX(1), EGFR(1), ETS1(1), ETS2(1), FOS(1), IKBKB(2), MAP2K1(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K5(1), MAPK13(1), MAPK3(1), MAPK8(5), NFKB1(3), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), RAF1(2) 5088007 41 15 41 12 15 13 8 2 3 0 0.103 0.381 167 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(1), CYP11B1(4), HSD17B2(1), HSD17B3(1), HSD3B1(1), HSD3B2(1), SRD5A2(1), STS(1), SULT1E1(1), SULT2A1(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1) 2699198 19 11 19 5 4 10 1 0 4 0 0.104 0.383 168 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGFR(1), ERBB3(3), NRG1(6) 1063036 10 7 10 1 2 2 4 0 2 0 0.105 0.386 169 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP2(3), MMP9(5), RECK(2), TIMP1(1), TIMP3(1) 784606 12 6 12 3 6 3 2 0 1 0 0.106 0.386 170 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(1), LCMT1(2), METTL2B(1), METTL6(3), PCYT1A(1), PRMT3(1), PRMT7(1), PRMT8(2) 1462893 12 7 12 2 3 4 2 1 2 0 0.107 0.386 171 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT2(1), B3GNT3(1), B4GALT1(1), B4GALT3(1), FUT1(3), FUT3(1), FUT9(1), GCNT2(2), ST3GAL6(3) 1576171 14 7 14 4 5 3 3 1 2 0 0.112 0.403 172 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(2), RB1(3), SP3(1) 693346 6 4 6 1 2 2 1 0 1 0 0.129 0.458 173 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(1), BRAF(2), CHUK(2), DAXX(1), FOS(1), GRB2(1), IKBKB(2), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K5(2), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K14(1), MAP3K2(1), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(3), MAPK10(4), MAPK13(1), MAPK3(1), MAPK6(1), MAPK8(5), MAPK9(2), MEF2A(1), MEF2C(2), MKNK2(1), NFKB1(3), PAK1(1), PAK2(1), RAF1(2), RPS6KA2(2), RPS6KA3(2), RPS6KA5(3), RPS6KB2(1), TGFB2(4), TGFBR1(3) 10078464 84 23 84 16 20 24 21 2 17 0 0.129 0.458 174 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(10), CDR1(1), DGKI(4), FAU(1), IL6ST(1), PIGK(1), RPL10(1), RPL11(1), RPL19(1), RPL28(1), RPL5(1), RPL6(2), RPL9(1), RPS16(1), RPS18(1), RPS2(1), RPS3(1), RPS4X(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(2), RPS6KB2(1), SLC36A2(1), UBB(1) 5423732 40 18 40 11 13 12 9 1 5 0 0.131 0.463 175 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CBS(1), CTH(1), LCMT1(2), MARS(3), MARS2(1), MAT2B(1), METTL2B(1), METTL6(3), PAPSS1(1), PAPSS2(2), PRMT3(1), PRMT7(1), PRMT8(2), SEPHS1(2) 2574184 22 10 22 4 5 8 4 1 4 0 0.134 0.472 176 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BCL2L11(1), CASP8AP2(6), CES1(1) 1191433 9 7 9 2 2 5 1 0 1 0 0.135 0.472 177 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT2(1), AKT3(1), BCR(1), BLNK(1), BTK(1), CSK(2), DAG1(1), EPHB2(1), GRB2(1), MAP2K1(1), MAP2K2(1), NFKB1(3), NFKB2(2), PI3(1), PIK3CA(7), PIK3CD(1), PIK3R1(5), PLCG2(4), PPP1R13B(1), RAF1(2), SERPINA4(3), SOS1(2), SOS2(2), SYK(3), VAV1(2) 5379115 50 15 50 7 19 15 8 0 6 2 0.137 0.477 178 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 17 DHRS2(1), LCMT1(2), METTL2B(1), METTL6(3), PRMT3(1), PRMT7(1), PRMT8(2) 1485674 11 7 11 3 4 3 1 1 2 0 0.138 0.477 179 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(1), GRIN2A(6), GRIN2B(2), GRIN2C(2), GRIN2D(2), NOS1(6), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2) 2639045 31 11 31 10 16 10 2 0 2 1 0.140 0.482 180 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(10), CDC25C(1), MYT1(5), YWHAH(1) 1441844 17 6 17 3 3 10 2 0 1 1 0.141 0.483 181 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(3), CD28(1), CSK(2), CTLA4(1), DAG1(1), DTYMK(1), EPHB2(1), FBXW7(12), GRAP2(3), GRB2(1), ITK(3), LAT(1), LCK(1), LCP2(1), NCK1(1), NFKB1(3), NFKB2(2), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PTPRC(8), RAF1(2), RASGRP1(3), RASGRP2(2), RASGRP3(3), RASGRP4(1), SOS1(2), SOS2(2), VAV1(2) 5787050 70 18 68 9 29 24 8 0 9 0 0.142 0.484 182 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT2(1), AKT3(1), CAP1(1), CBL(3), CDC42(1), F2RL2(1), GRB2(1), GSK3B(1), INPPL1(1), IRS1(3), IRS4(4), LNPEP(2), MAPK3(1), PARD3(2), PARD6A(2), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), PPYR1(3), PTEN(4), PTPN1(1), RAF1(2), RPS6KA2(2), RPS6KA3(2), SERPINB6(1), SLC2A4(1), SORBS1(4), SOS1(2), SOS2(2), YWHAH(1) 5972963 65 16 65 11 24 18 12 0 9 2 0.147 0.494 183 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH3B1(1), AOX1(3), DBH(1), DCT(4), FAH(1), GOT1(1), HGD(1), HPD(1), MAOA(1), MAOB(1), TAT(2), TPO(3), TYR(1) 3231925 28 12 28 12 4 16 3 0 5 0 0.147 0.494 184 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(1), BLVRB(1), CP(3), CPOX(1), EPRS(2), FECH(1), HCCS(2), HMOX2(2), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1), UROD(1) 2696948 19 10 19 3 5 9 3 0 2 0 0.149 0.497 185 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 57 ACMSD(1), AFMID(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), AOX1(3), CAT(1), CYP1A1(1), CYP1A2(1), CYP1B1(1), GCDH(2), HADHA(1), HSD17B10(1), INMT(1), KMO(2), KYNU(1), LCMT1(2), LNX1(4), MAOA(1), MAOB(1), METTL2B(1), METTL6(3), NFX1(3), OGDHL(3), PRMT3(1), PRMT7(1), PRMT8(2), TDO2(2), TPH1(2), TPH2(3), WARS(1), WARS2(1) 6225135 54 17 54 18 13 23 8 1 9 0 0.149 0.497 186 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AMD1(1), BHMT(2), CBS(1), CTH(1), DNMT1(7), DNMT3A(2), DNMT3B(5), MARS(3), MARS2(1), MAT2B(1), MTAP(1), MTFMT(1), MTR(1), TAT(2) 2163774 29 9 29 5 11 13 1 1 3 0 0.153 0.506 187 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(4), CFTR(4), PRKACG(1), PRKAR1A(4), PRKAR2B(1) 1317832 14 7 14 3 5 6 1 0 2 0 0.155 0.509 188 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(2), DNMT1(7), PTGDR(1), PTGFR(1) 1141950 11 7 11 1 7 3 0 1 0 0 0.155 0.509 189 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1R(1), C1S(3), C2(4), C3(1), C5(4), C6(3), C7(3), C8A(3), C9(1) 1824828 23 8 23 5 7 9 4 0 3 0 0.157 0.512 190 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(3), CALR(1), CIITA(1), CTSB(3), CTSL1(1), HLA-A(2), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-F(1), HLA-G(1), HSP90AA1(1), HSP90AB1(2), HSPA5(1), IFNA10(2), IFNA2(1), KIR3DL1(1), KIR3DL2(1), KLRC3(1), LGMN(2), NFYA(2), PDIA3(1), TAP1(2), TAP2(1), TAPBP(2) 4559458 42 12 42 12 7 20 7 1 5 2 0.158 0.513 191 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(1), PARK2(2), SNCAIP(2), UBE2E2(1) 656463 6 4 6 1 1 4 1 0 0 0 0.161 0.520 192 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(2), CAMK1G(2), GNGT1(1), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP3K1(2), MAPK3(1), NCF2(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), PAK1(1), PIK3C2G(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), RAF1(2) 3996042 33 12 33 11 12 11 5 1 4 0 0.165 0.522 193 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD8(1), ACAD9(2), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), DHRS2(1), ESCO1(4), ESCO2(1), MYST3(5), MYST4(5), SH3GLB1(1) 2528280 25 9 25 9 6 9 8 0 2 0 0.166 0.522 194 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(1), GLI2(2), GLI3(4), GSK3B(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), SMO(1) 1661442 15 8 15 3 4 8 0 0 3 0 0.166 0.522 195 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(3), GZMB(1), HLA-A(2), ITGAL(3), ITGB2(1) 873728 10 5 10 3 2 3 2 0 2 1 0.166 0.522 196 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(4), CREBBP(4), CSK(2), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PTPRC(8) 2340908 28 10 28 5 12 11 2 0 3 0 0.167 0.522 197 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(4), CREBBP(4), CSK(2), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PTPRC(8) 2340908 28 10 28 5 12 11 2 0 3 0 0.167 0.522 198 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT4(2), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(4), ENPP6(1), PAFAH1B3(2), PAFAH2(1), PLA2G4A(3), PLA2G6(2), PLD1(3), PLD2(1) 2418424 23 10 23 8 11 8 2 0 2 0 0.170 0.529 199 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT2(1), AKT3(1), BCR(1), BLNK(1), BTK(1), CD22(2), CR2(2), CSK(2), DAG1(1), GRB2(1), GSK3B(1), INPP5D(2), ITPR1(8), ITPR2(6), ITPR3(1), MAP4K1(1), MAPK3(1), NFATC1(1), NFATC2(2), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), PLCG2(4), PPP1R13B(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PTPRC(8), RAF1(2), SOS1(2), SOS2(2), SYK(3), VAV1(2) 7650721 79 19 79 10 29 28 8 0 11 3 0.173 0.532 200 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ARHGEF11(2), BTK(1), CDC42(1), INPPL1(1), ITPR1(8), ITPR2(6), ITPR3(1), LIMK1(1), MYLK(3), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PPP1R13B(1), PTEN(4), RHO(1), ROCK1(7), ROCK2(4), RPS4X(1), WASF1(2), WASL(2) 7367020 75 18 75 10 29 20 9 0 14 3 0.173 0.532 201 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(1), CTNNB1(4), CTTN(1), FYN(1), HCLS1(1), NCK1(1), NCL(1), PRKCA(2), RHOA(1), ROCK1(7), ROCK2(4), TLR4(3), TLR5(1), TUBA1B(2), TUBA1C(2), TUBA3D(1), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB2A(2), TUBB3(1), TUBB4(1), TUBB8(1), WASL(2) 5347332 48 16 48 10 17 17 8 0 6 0 0.176 0.538 202 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(1), CTNNB1(4), CTTN(1), FYN(1), HCLS1(1), NCK1(1), NCL(1), PRKCA(2), RHOA(1), ROCK1(7), ROCK2(4), TLR4(3), TLR5(1), TUBA1B(2), TUBA1C(2), TUBA3D(1), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB2A(2), TUBB3(1), TUBB4(1), TUBB8(1), WASL(2) 5347332 48 16 48 10 17 17 8 0 6 0 0.176 0.538 203 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(1), C5(4), C6(3), C7(3), IL6(1), IL8(1), ITGA4(5), ITGAL(3), ITGB2(1), SELP(2), SELPLG(1), VCAM1(2) 2578107 27 9 27 9 9 10 3 0 5 0 0.181 0.550 204 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11A1(2), HSD3B1(1), HSD3B2(1) 713979 4 4 4 2 1 2 0 0 1 0 0.182 0.551 205 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA4(1), NDUFS1(2), NDUFS2(3) 724637 6 4 6 2 3 2 0 0 1 0 0.186 0.558 206 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(5), ATP4A(2), ATP5A1(3), ATP5C1(2), ATP5L(2), ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), COX15(2), COX4I2(1), LHPP(1), NDUFA4(1), NDUFA9(1), NDUFB9(1), NDUFS1(2), NDUFS2(3), NDUFS4(1), NDUFS5(2), NDUFV3(1), PPA2(2), SDHA(1), UQCRC2(1) 5834296 48 17 48 12 17 17 9 0 5 0 0.186 0.558 207 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(1), CTPS(1), DCK(1), DHODH(1), DPYD(6), DPYS(1), DTYMK(1), NT5E(1), POLB(2), POLE(4), POLG(1), POLL(1), POLQ(4), POLR1B(2), POLR2B(3), POLR2K(1), RRM1(1), TK2(1), TXNRD1(1), TYMS(1), UMPS(1), UPB1(2) 5987713 38 18 37 12 11 13 7 0 7 0 0.190 0.565 208 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), DLD(1), DLST(1), IDH3A(3), PC(3), PCK1(3), SDHA(1), SUCLA2(2), SUCLG1(1) 2150888 16 9 16 9 3 8 2 0 3 0 0.191 0.566 209 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(4), CPT1A(1), LEPR(4), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1) 1506928 15 6 15 7 7 5 2 0 1 0 0.203 0.598 210 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ACADL(2), ACADM(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), DPYD(6), DPYS(1), GAD1(2), HADHA(1), UPB1(2) 3002676 22 11 22 12 6 8 2 0 6 0 0.204 0.599 211 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNGT1(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2) 976829 9 6 9 1 4 4 0 0 1 0 0.211 0.617 212 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(1), ALAS1(1), ALAS2(1), BLVRB(1), COX15(2), CP(3), CPOX(1), EPRS(2), FECH(1), FTMT(1), HCCS(2), HMOX2(2), MMAB(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2), UROD(1) 4156604 35 12 35 7 9 18 5 0 3 0 0.217 0.632 213 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(1), B3GNT7(2), B4GALT1(1), B4GALT3(1), CHST1(1), CHST4(2), FUT8(1) 1226888 9 5 9 3 4 1 1 1 2 0 0.219 0.634 214 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(1), EPX(1), LPO(1), MPO(2), MTHFR(1), SHMT1(1), TPO(3) 1211963 10 7 10 6 6 3 1 0 0 0 0.222 0.639 215 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ADSS(1), AK2(1), AK5(1), AK7(1), ALLC(2), AMPD1(2), AMPD2(1), AMPD3(1), DCK(1), ENPP3(1), ENTPD5(1), ENTPD6(1), GMPR(1), GUCY1A2(4), GUCY1A3(5), GUCY1B3(2), GUCY2C(1), GUCY2D(4), GUCY2F(4), IMPDH1(1), IMPDH2(3), NME6(1), NME7(2), NPR2(1), NT5C1B(1), NT5C2(1), NT5E(1), PAICS(1), PAPSS1(1), PAPSS2(2), PDE10A(5), PDE11A(1), PDE1A(1), PDE1C(2), PDE3B(1), PDE4B(3), PDE4D(1), PDE5A(3), PDE7B(1), PDE8B(1), PDE9A(1), PNPT1(5), POLA1(3), POLE(4), POLE2(1), POLR1A(3), POLR1B(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(5), POLR3K(1), PPAT(3), PRIM2(3), PRPS1(1), PRUNE(1), RFC5(1), RRM1(1) 17173958 128 34 126 38 40 49 16 0 23 0 0.229 0.655 216 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 CAT(1), EPX(1), LPO(1), MPO(2), PRDX1(1), SHMT1(1), TPO(3) 1233384 10 7 10 7 5 3 1 0 1 0 0.233 0.664 217 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR161(2), GPR171(1), GPR18(2), GPR34(1), GPR39(1), GPR45(3), GPR65(1), GPR75(1) 1023567 13 6 13 3 5 3 2 0 3 0 0.234 0.664 218 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BRAF(2), CREB3(1), CREB5(2), DUSP6(1), EEF2K(1), GRB2(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MKNK2(1), MOS(1), NFKB1(3), RAP1A(1), RPS6KA2(2), RPS6KA3(2), SOS1(2), SOS2(2), TRAF3(2) 3099188 28 10 28 2 8 9 7 1 3 0 0.237 0.669 219 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLUD2(2) 447954 2 2 2 1 0 2 0 0 0 0 0.242 0.680 220 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), BDKRB2(1), CAV1(1), CHRNA1(2), FLT1(3), FLT4(1), KDR(2), PDE3B(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKG1(5), PRKG2(2), RYR2(11) 4241398 36 13 36 12 7 17 9 0 3 0 0.244 0.681 221 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXTL2(3), EXTL3(2), GLCE(3), HS2ST1(1), HS3ST1(1), HS3ST2(2), NDST1(1), NDST3(3) 2164228 17 9 17 9 5 6 3 1 2 0 0.245 0.681 222 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(2), HSD17B2(1), HSD17B3(1), HSD3B1(1), HSD3B2(1) 834294 6 4 6 2 1 3 1 0 1 0 0.245 0.681 223 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(4), PLCE1(2), PRKACG(1), PRKAR1A(4), PRKAR2B(1), RAP2B(1) 1488089 13 7 13 2 5 6 1 0 1 0 0.250 0.686 224 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HADHA(1), HADHB(1), HSD17B10(1), PPT2(1) 874545 5 4 5 4 1 2 0 0 2 0 0.251 0.686 225 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), CARS(1), DARS(1), EPRS(2), FARS2(1), IARS(1), LARS(1), LARS2(1), MARS(3), MARS2(1), NARS(1), QARS(1), RARS(2), SARS(1), TARS(3), WARS(1), WARS2(1) 3313083 23 10 23 5 3 9 7 1 3 0 0.252 0.686 226 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ACADM(3), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), DPYD(6), DPYS(1), GAD1(2), HADHA(1), HIBCH(1), UPB1(2) 2790554 22 10 22 11 5 9 2 0 6 0 0.252 0.686 227 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(3), GPD2(1), SDHA(1) 676873 5 4 5 0 1 1 3 0 0 0 0.259 0.703 228 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(1), AASS(2) 492269 3 3 3 2 0 0 2 0 1 0 0.263 0.711 229 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1), LIPT1(2) 157941 3 2 3 1 0 2 1 0 0 0 0.266 0.715 230 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 FOS(1), GRB2(1), IL6(1), IL6R(1), IL6ST(1), JAK1(1), JAK2(3), JAK3(2), MAP2K1(1), MAPK3(1), PTPN11(3), RAF1(2), SOS1(2) 2486050 20 9 20 3 6 7 3 0 3 1 0.269 0.722 231 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(2), ALG1(1), ALG10B(3), ALG14(1), ALG8(1), ALG9(1), B3GNT2(1), B3GNT7(2), B4GALT1(1), B4GALT3(1), CHST1(1), CHST11(1), CHST12(1), CHST13(1), CHST4(2), DPAGT1(1), EXT1(1), EXTL2(3), EXTL3(2), FUT11(1), FUT8(1), GALNT12(1), GALNT14(1), GALNT2(1), GALNT5(4), GALNT6(1), GALNT7(1), GALNT8(1), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(2), HS2ST1(1), HS3ST1(1), HS3ST2(2), MAN1A1(1), MAN1C1(3), MAN2A1(4), MGAT1(1), NDST1(1), NDST3(3), OGT(1), RPN2(1), ST6GALNAC1(1), STT3B(2), WBSCR17(2), XYLT1(2) 11366322 79 23 79 31 22 30 17 2 8 0 0.272 0.726 232 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 SUCLA2(2) 223070 2 2 2 1 0 2 0 0 0 0 0.280 0.739 233 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(2), HDAC9(2), MEF2A(1), MEF2C(2), YWHAH(1) 871035 10 5 10 3 1 6 0 0 3 0 0.282 0.739 234 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(1), CD79B(1), FOS(1), GRB2(1), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8(5), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), RAF1(2), SOS1(2), SYK(3), VAV1(2) 3926455 34 12 34 8 12 12 4 1 5 0 0.282 0.739 235 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(1), LPO(1), MPO(2), PRDX1(1), TPO(3), TYR(1) 1009707 9 6 9 5 6 2 0 0 1 0 0.283 0.739 236 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(2), F2(1), FGA(2), FGB(1), PLAT(1), PLAU(1), PLG(2), SERPINB2(1), SERPINE1(2) 1393926 14 5 14 0 7 4 1 0 2 0 0.283 0.739 237 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOC(2), DERA(1), FBP2(1), G6PD(1), GPI(1), H6PD(1), PFKM(3), PGM1(2), PGM3(1), PRPS1(1), TKTL1(1), TKTL2(2) 2510791 17 10 17 5 7 7 2 0 1 0 0.288 0.749 238 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(1), KERA(2), LUM(1) 376414 5 3 5 1 3 0 2 0 0 0 0.289 0.749 239 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA3(1), PSMA7(1), PSMB3(1), PSMB8(3) 872784 6 4 6 0 0 5 0 1 0 0 0.299 0.766 240 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT3(1), CAPN11(1), CAPN2(1), CAPN6(1), CAPN7(1), CAV1(1), CAV3(1), CDC42(1), CSK(2), DOCK1(2), FYN(1), GIT2(1), GRB2(1), ITGA10(4), ITGA11(2), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAD(1), ITGAE(2), ITGAL(3), ITGAM(3), ITGAV(4), ITGAX(2), ITGB2(1), ITGB3(2), ITGB4(1), ITGB5(1), ITGB8(1), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAPK10(4), MAPK6(1), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), RAPGEF1(2), RHO(1), ROCK1(7), ROCK2(4), SEPP1(1), SORBS1(4), SOS1(2), TLN1(2), TNS1(3), VAV2(2), VAV3(2), VCL(1), ZYX(1) 14132327 105 27 105 32 29 43 16 4 13 0 0.301 0.766 241 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(3), CLOCK(3), CRY1(3) 888954 9 4 9 1 1 3 2 0 2 1 0.303 0.766 242 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1) 1580765 11 6 11 2 3 5 2 0 1 0 0.303 0.766 243 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1) 1580765 11 6 11 2 3 5 2 0 1 0 0.303 0.766 244 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1) 1580765 11 6 11 2 3 5 2 0 1 0 0.303 0.766 245 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(3), CBX3(2), CLOCK(3), CRY1(3), DNAJA1(1), ETV6(1), GFRA1(5), GSTM3(1), HSPA8(1), MYF6(1), NCKAP1(1), NCOA4(1), NR1D2(3), PPP1R3C(2), PPP2CB(2), TOB1(2), TUBB3(1), UGP2(2), ZFR(5) 3799487 40 11 40 5 5 15 13 0 6 1 0.305 0.768 246 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1) 581877 5 3 5 4 0 2 2 0 1 0 0.314 0.787 247 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ATF1(1), ATF2(1), ATF4(1), ATP2A2(1), ATP2A3(1), CACNB3(1), CAMK2D(1), CNN1(1), CNN2(1), CORIN(3), CREB3(1), CRHR1(1), DGKZ(1), ETS2(1), FOS(1), GABPB2(1), GJA1(4), GNAQ(1), GNG4(1), GNGT1(1), GRK5(1), GUCY1A3(5), IGFBP3(2), IL1B(1), IL6(1), ITPR1(8), ITPR2(6), ITPR3(1), MIB1(3), MYL4(1), MYLK2(1), NFKB1(3), NOS1(6), OXTR(1), PDE4B(3), PDE4D(1), PLCB3(1), PLCD1(1), PLCG2(4), PRKACA(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PRKCE(2), PRKCH(1), PRKCQ(1), PRKD1(5), RAMP3(1), RGS17(1), RGS2(2), RGS20(1), RGS3(2), RGS4(1), RGS5(1), RGS7(2), RGS9(3), RLN1(1), RYR1(6), RYR2(11), RYR3(11), SLC8A1(2), TNXB(3), USP5(1), YWHAH(1) 18102940 158 36 158 47 56 71 11 1 18 1 0.316 0.789 248 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG2(1), ASL(2), ASS1(1), CKM(1), CKMT2(3), CPS1(6), DAO(4), EPRS(2), GLUD2(2), GOT1(1), LAP3(1), NOS1(6), OAT(1), OTC(1), P4HA1(1), P4HA3(1), RARS(2), RARS2(2) 3674702 39 10 39 12 13 14 5 1 6 0 0.321 0.798 249 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CSNK1D(1), DRD2(2), GRM1(3), PPP3CA(2), PRKACG(1), PRKAR1A(4), PRKAR2B(1) 1639986 14 7 14 6 8 3 1 0 2 0 0.324 0.802 250 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(2), CPS1(6), GOT1(1) 790158 9 4 9 2 2 3 1 0 3 0 0.329 0.808 251 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1), CBS(1), CTH(1), MUT(1) 503229 4 3 4 0 1 2 0 0 1 0 0.329 0.808 252 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT2(1), AKT3(1), CDC42(1), CDKN1B(2), CREB3(1), CREB5(2), ERBB4(5), F2RL2(1), GRB2(1), GSK3B(1), INPPL1(1), IRS1(3), IRS4(4), MET(1), NOLC1(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PARD3(2), PARD6A(2), PDK1(2), PIK3CA(7), PIK3CD(1), PPP1R13B(1), PREX1(2), PTEN(4), PTPN1(1), RPS6KA2(2), RPS6KA3(2), SLC2A4(1), SOS1(2), SOS2(2), TSC1(1), TSC2(1), YWHAH(1) 7798506 67 17 67 16 19 23 12 1 12 0 0.332 0.809 253 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(3), FUT3(1) 493494 4 3 4 1 3 1 0 0 0 0 0.332 0.809 254 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(4), EGFR(1), TF(4), TFRC(1) 1327975 10 5 10 1 3 5 1 0 1 0 0.334 0.811 255 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(5), ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), ATP7A(1), NDUFA4(1), NDUFS1(2), NDUFS2(3), PPA2(2), SDHA(1), SHMT1(1) 3833909 26 11 26 9 7 13 3 0 3 0 0.339 0.820 256 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AGK(1), AGPAT1(1), AGPAT4(2), AGPAT6(1), AKR1B1(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), DAK(1), DGAT2(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKI(4), DGKZ(1), GK2(3), GPAM(1), LCT(5), LIPC(1), LIPF(2), MGLL(1), PNLIP(2), PNLIPRP2(1) 6071385 52 16 52 16 20 19 8 0 5 0 0.342 0.822 257 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOC(2), FBP2(1), G6PD(1), GPI(1), H6PD(1), PFKM(3), PGM1(2), PGM3(1), PRPS1(1) 2106811 13 8 13 3 6 6 1 0 0 0 0.343 0.822 258 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 GNAQ(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), SP3(1) 2111404 13 7 13 5 8 2 0 0 3 0 0.348 0.830 259 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1) 1673779 11 6 11 2 3 5 2 0 1 0 0.350 0.831 260 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK2(3), JAK3(2), MAPK3(1) 1234284 7 5 7 1 0 3 0 0 3 1 0.351 0.831 261 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), CKM(1), LDHA(1), LDHB(2), NCL(1) 919319 8 5 8 4 3 5 0 0 0 0 0.353 0.831 262 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 ERCC3(1), GTF2F2(1), GTF2H1(2), POLR1A(3), POLR1B(2), POLR2B(3), POLR2K(1), POLR3B(5), POLR3E(3), POLR3K(1), TAF5(1), TAF6(1), TAF7(1), TAF9(1) 3650174 26 11 26 4 10 8 3 0 5 0 0.353 0.831 263 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(2), SPCS3(1) 324309 3 2 3 1 2 1 0 0 0 0 0.357 0.836 264 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), AFMID(1), GRHPR(1), HAO2(1), MTHFD1L(2) 1397283 6 5 6 5 2 2 0 1 1 0 0.366 0.853 265 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACO1(1), CLYBL(1), DLD(1), DLST(1), IDH3A(3), OGDHL(3), PC(3), PCK1(3), SDHA(1), SUCLA2(2), SUCLG1(1) 3108673 20 10 20 11 4 8 5 0 3 0 0.371 0.860 266 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ACTN1(2), ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ARHGEF6(3), BRAF(2), CAV1(1), CDC42(1), DOCK1(2), EPHB2(1), FYN(1), GRB2(1), GRLF1(5), ITGA10(4), ITGA11(2), ITGA2(1), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGB3BP(2), MAP2K4(2), MAPK10(4), MAPK8(5), MAPK8IP3(1), MAPK9(2), MYLK(3), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PIK3CA(7), PLCG2(4), PTEN(4), RAF1(2), RALA(1), RHO(1), ROCK1(7), ROCK2(4), SOS1(2), SOS2(2), TERF2IP(1), TLN1(2), TLN2(3), ZYX(1) 12734557 109 24 109 37 35 33 20 3 18 0 0.372 0.860 267 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ALAS1(1), ALAS2(1), BHMT(2), CBS(1), CHDH(1), CHKA(2), CTH(1), DAO(4), DLD(1), DMGDH(2), GCAT(1), GLDC(1), MAOA(1), MAOB(1), PISD(2), PLCG2(4), SARDH(1), SARS(1), SHMT1(1), TARS(3) 4399262 32 13 32 13 14 12 3 0 3 0 0.373 0.860 268 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(4), ADCY2(3), ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(2), ADORA2A(2), ADRA1B(1), ADRB1(1), AGTR1(2), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(4), ATP2B4(3), AVPR1A(1), BDKRB2(1), CACNA1A(9), CACNA1B(4), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1F(2), CACNA1I(2), CACNA1S(4), CAMK2D(1), CAMK4(1), CCKAR(1), CCKBR(2), CD38(1), CHRM2(3), CHRM5(1), CHRNA7(1), CYSLTR2(1), EDNRB(5), EGFR(1), ERBB2(4), ERBB3(3), ERBB4(5), GNA14(1), GNAL(1), GNAQ(1), GRIN2A(6), GRIN2C(2), GRIN2D(2), GRM1(3), GRM5(3), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(3), HTR7(1), ITPR1(8), ITPR2(6), ITPR3(1), MYLK(3), MYLK2(1), NOS1(6), OXTR(1), P2RX2(1), P2RX4(1), P2RX7(1), PDE1A(1), PDE1B(1), PDE1C(2), PDGFRA(4), PDGFRB(1), PHKA1(4), PHKA2(1), PHKB(2), PHKG2(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCE1(2), PLCG2(4), PLCZ1(1), PLN(1), PPID(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), PTGER3(1), PTGFR(1), RYR1(6), RYR2(11), RYR3(11), SLC8A1(2), SLC8A2(1), SLC8A3(3), SPHK1(1), TACR3(3), TRHR(2), TRPC1(1) 28541570 229 48 227 83 91 88 27 1 20 2 0.376 0.860 269 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ASPA(2), HAL(1), HDC(5), MAOA(1), MAOB(1), PRPS1(1) 2540877 17 9 17 12 5 8 2 0 2 0 0.377 0.860 270 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(3), HADHA(1) 560426 6 3 6 3 2 1 0 0 3 0 0.377 0.860 271 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ITGA4(5), ITGAL(3), ITGAM(3), ITGB2(1), PECAM1(1), SELE(2), SELL(3), SELP(2) 1768100 20 7 20 6 3 11 3 0 3 0 0.378 0.860 272 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 PLA2G6(2), PTGIS(1), PTGS1(2), PTGS2(1) 1564856 6 6 6 2 4 2 0 0 0 0 0.384 0.870 273 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(1), CASP3(1), DAXX(1), FAS(2), HSPB2(1) 1153636 7 5 7 1 1 1 4 0 1 0 0.387 0.871 274 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(2), SRP54(2), SRP68(3), SRP72(1), SRPR(1) 778871 9 4 9 1 2 6 0 0 1 0 0.390 0.871 275 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(3), AGT(1), AGTR2(1), EDNRB(5), EGFR(1), FOS(1), NFKB1(3), PRKCA(2) 2126702 17 8 17 5 7 6 3 0 1 0 0.390 0.871 276 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), CYP4F3(1), EPX(1), LPO(1), MPO(2), PLA2G4A(3), PLA2G6(2), PRDX1(1), PTGIS(1), PTGS1(2), PTGS2(1), TPO(3) 2893287 20 10 20 9 12 5 1 0 2 0 0.393 0.871 277 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(2), AP2A1(1), BIN1(1), DNM1(3), EPN1(1), EPS15(3), PPP3CA(2), PPP3CB(1), PPP3CC(1), SYNJ1(3), SYNJ2(1) 2350664 19 8 19 3 8 7 0 0 4 0 0.396 0.871 278 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(4), ACADL(2), ACADM(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH6A1(1), HADHA(1), LDHA(1), LDHB(2), MCEE(1), MUT(1), PCCA(6), PCCB(1), SUCLA2(2), SUCLG1(1) 3433782 31 10 31 8 9 11 3 0 8 0 0.397 0.871 279 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP4(1), BMP5(1), BMP7(1), BTRC(3), CSNK1D(1), CSNK1G3(1), FBXW11(1), GLI1(1), GLI2(2), GLI3(4), GSK3B(1), HHIP(1), LRP2(13), PRKACA(1), PRKACG(1), PTCH1(1), PTCH2(2), RAB23(1), SMO(1), STK36(1), WNT10B(1), WNT2(1), WNT2B(2), WNT6(1), WNT8A(1), WNT9B(1) 6176949 47 17 47 14 19 18 3 0 7 0 0.397 0.871 280 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), CES1(1), CES7(1), DDHD1(2), ESCO1(4), ESCO2(1), MYST3(5), MYST4(5), SH3GLB1(1) 2625276 21 8 21 9 5 8 6 0 2 0 0.400 0.871 281 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 DHRS2(1), PON1(1), PON2(1), RDH11(1), RDH12(1) 872594 5 4 5 3 3 2 0 0 0 0 0.403 0.871 282 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ADCY3(1), ADCY9(2), ARF4(1), ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), ERO1L(1), PDIA4(1), PLCG2(4), PRKCA(2), TRIM23(4) 3825030 28 10 28 5 12 8 5 0 3 0 0.403 0.871 283 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(1), GNAQ(1), GNGT1(1), LIMK1(1), MAP2K1(1), MAPK3(1), PIK3C2G(2), PPP1R12B(4), PRKCA(2), RAF1(2), ROCK2(4) 2649446 20 8 20 5 6 6 2 0 6 0 0.404 0.871 284 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25C(1), CSK(2), GRB2(1), PRKCA(2) 965430 6 4 6 1 2 4 0 0 0 0 0.405 0.871 285 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACPP(1), ALPPL2(1), CYP19A1(3), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(3), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP3A7(2), CYP4B1(1), PON1(1) 3037416 24 9 24 7 8 5 8 0 2 1 0.405 0.871 286 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(1), ACADL(2), ACADM(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH6A1(1), AOX1(3), HADHA(1), HADHB(1), HMGCL(1), MCCC1(1), MCEE(1), MUT(1), PCCA(6), PCCB(1) 3748527 28 11 28 9 8 10 3 0 7 0 0.408 0.871 287 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(2) 188292 3 2 3 0 0 2 1 0 0 0 0.408 0.871 288 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(1), LPO(1), MPO(2), TPO(3) 881355 7 5 7 4 5 2 0 0 0 0 0.411 0.871 289 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT1(1), AGPAT4(2), AGPS(1), CDS1(1), CHKA(2), CLC(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKZ(1), GNPAT(1), GPD2(1), PAFAH2(1), PCYT1A(1), PISD(2), PLA2G4A(3), PLA2G6(2), PLCG2(4) 5192979 38 14 38 14 18 7 7 0 6 0 0.412 0.871 290 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), GRHPR(1), HAO2(1), MTHFD1L(2) 1332086 5 4 5 5 1 2 0 1 1 0 0.415 0.871 291 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(2), RANBP2(8) 860171 10 4 10 3 1 4 5 0 0 0 0.416 0.871 292 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1B(1), ADRB1(1), CHRM2(3), CHRM4(1), CHRM5(1), DRD2(2), DRD5(4), HTR1A(2), HTR1B(2), HTR1E(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(3), HTR7(1) 2590718 27 9 27 14 13 9 3 1 1 0 0.416 0.871 293 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(2), BIRC3(5), CASP3(1), CFLAR(1), MAP2K4(2), MAP3K3(1), MAP3K7(2), NFKB1(3), NFKB2(2), RALBP1(2), TNFAIP3(1) 2744904 22 8 22 5 9 5 4 0 4 0 0.417 0.871 294 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(3), GABRA1(2), GABRA2(3), GABRA3(1), GABRA4(2), GABRA5(1), GABRA6(1), GPHN(1) 1251150 14 5 14 2 3 9 2 0 0 0 0.420 0.871 295 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTN2(1), ACTN3(1), ACTN4(1), DMD(11), FAM48A(2), MYBPC1(2), MYBPC3(1), MYH3(5), MYH6(4), MYH7(4), MYH8(3), MYL4(1), MYL9(2), MYOM1(4), NEB(16), TMOD1(1), TPM2(1), TPM3(1), TPM4(1), TTN(87), VIM(1) 14574470 151 26 151 41 45 63 30 0 11 2 0.422 0.871 296 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS2(1), ESCO1(4), ESCO2(1), MYST3(5), MYST4(5), SH3GLB1(1) 1650219 17 6 17 4 5 6 5 0 1 0 0.424 0.871 297 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(2) 337034 2 2 2 0 0 1 1 0 0 0 0.424 0.871 298 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(2), CUL1(1), RB1(3) 909957 6 3 6 4 1 0 2 0 3 0 0.425 0.871 299 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ACTR3(1), ARHGAP5(3), ARHGAP6(1), ARHGEF1(1), ARHGEF11(2), ARPC2(1), BAIAP2(1), LIMK1(1), MYLK(3), OPHN1(3), PIP5K1B(1), PPP1R12B(4), ROCK1(7), TLN1(2), VCL(1) 4834081 33 12 33 7 8 9 9 0 7 0 0.426 0.871 300 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 HMGCL(1) 349623 1 1 1 1 1 0 0 0 0 0 0.426 0.871 301 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 GALNT12(1), GALNT14(1), GALNT2(1), GALNT5(4), GALNT6(1), GALNT7(1), GALNT8(1), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(2), OGT(1), ST6GALNAC1(1), WBSCR17(2) 3350529 28 9 28 7 5 14 7 0 2 0 0.427 0.871 302 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(3), ABCC2(3), ABCG2(4), BCHE(2), CES1(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1) 2358383 17 7 17 3 5 8 2 1 1 0 0.427 0.871 303 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(1), AASDHPPT(1), AASS(2) 723285 4 3 4 3 0 1 2 0 1 0 0.430 0.871 304 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ME1(2), PC(3), PDHA1(1) 959216 6 4 6 3 4 2 0 0 0 0 0.430 0.871 305 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 CES1(1), ESD(1) 607156 2 2 2 5 0 2 0 0 0 0 0.431 0.871 306 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT1(1), FBP2(1), G6PC(1), GALK2(1), GCK(1), HK3(1), LALBA(1), LCT(5), MGAM(4), PFKM(3), PGM1(2), PGM3(1) 3387174 23 10 23 6 11 9 2 0 1 0 0.434 0.873 307 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(6), MAP2(4), PRKACG(1), PRKAR2B(1), PRKCE(2) 1894613 14 6 13 7 2 7 3 0 2 0 0.435 0.873 308 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(3), POLB(2), POLE(4), POLE2(1), POLG(1), POLH(1), POLI(3), POLK(1), POLL(1), POLM(1), POLQ(4), PRIM2(3), REV1(3), REV3L(7), RFC5(1) 4349939 36 11 34 10 7 14 5 0 9 1 0.446 0.891 309 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT5(2), FUT1(3), FUT3(1) 741030 6 3 6 2 4 1 1 0 0 0 0.452 0.900 310 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA2(1), ACADM(3), ALDH1A3(2), ALDH1B1(2), ALDH6A1(1), ALDH7A1(2), AOX1(3), DLD(1), HADHA(1), HADHB(1), HIBCH(1), HMGCL(1), HMGCS2(1), HSD17B10(1), MCCC1(1), MCEE(1), MUT(1), PCCA(6), PCCB(1) 4499750 31 12 31 9 9 11 3 0 8 0 0.453 0.900 311 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOC(2) 392439 3 2 3 0 2 0 1 0 0 0 0.456 0.903 312 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CHUK(2), FOS(1), IKBKB(2), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK8(5), MYD88(1), NFKB1(3), TLR10(3), TLR2(4), TLR3(1), TLR4(3), TLR7(3), TLR9(3) 3790894 43 9 43 8 11 17 9 2 3 1 0.459 0.906 313 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(5), ABCB11(3), ABCB4(3), ABCC1(3) 1509011 14 5 14 3 4 6 2 1 1 0 0.463 0.912 314 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE2(3), AGT(1), AGTR1(2), AGTR2(1), ANPEP(3), CPA3(1), CTSG(1), ENPEP(2), LNPEP(2), MAS1(1), MME(4), NLN(2), REN(2) 2183198 25 7 25 7 8 11 4 0 2 0 0.466 0.914 315 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(2), FUCA1(2), HEXB(2), LCT(5), MANBA(1), NEU1(1) 1691523 13 6 13 3 5 4 1 0 3 0 0.473 0.923 316 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(1), CTH(1), MARS(3), MARS2(1), MAT2B(1), PAPSS1(1), PAPSS2(2), SEPHS1(2) 1281961 12 5 12 2 2 5 3 0 2 0 0.474 0.923 317 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 AGMAT(4), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), AMD1(1), ARG2(1), ASL(2), ASS1(1), CPS1(6), MAOA(1), MAOB(1), NAGS(1), ODC1(3), OTC(1), SAT2(1) 3082757 29 9 28 7 10 11 3 0 5 0 0.476 0.923 318 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 53 ACMSD(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), AOX1(3), CAT(1), CYP19A1(3), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(3), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP3A7(2), CYP4B1(1), GCDH(2), HADHA(1), KMO(2), KYNU(1), MAOA(1), MAOB(1), TDO2(2), TPH1(2), WARS(1), WARS2(1) 5657681 45 14 45 18 11 19 10 0 5 0 0.477 0.923 319 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(1), ACAD8(1), ACAD9(2), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AKR1C4(1), AKR1D1(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), HADHB(1), RDH11(1), RDH12(1), SLC27A5(1), SRD5A2(1) 3332649 22 9 22 13 4 11 5 0 2 0 0.480 0.924 320 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX3(2), FADS2(1), PLA2G4A(3), PLA2G6(2) 1074095 8 5 8 3 6 1 0 0 1 0 0.481 0.924 321 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(2), GABRA2(3), GABRA3(1), GABRA4(2), GABRA5(1), GABRA6(1), PRKCE(2) 821648 12 3 12 3 2 8 1 0 1 0 0.482 0.924 322 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 NEK1(2) 782655 2 2 2 0 0 1 0 1 0 0 0.484 0.924 323 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(1), GNAI1(1), GNGT1(1), MAP2K1(1), MAPK3(1), PLA2G4A(3), PRKCA(2), PTGS1(2), RAF1(2), SYK(3) 2528848 17 8 17 5 6 5 2 0 4 0 0.484 0.924 324 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(1), MAPK8(5), NFE2L2(3), PRKCA(2) 901011 11 4 11 0 4 4 1 1 1 0 0.487 0.924 325 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PRKCA(2) 698032 3 3 3 2 2 1 0 0 0 0 0.487 0.924 326 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(1), CYP2A6(3) 827924 5 3 5 3 1 2 1 0 1 0 0.490 0.925 327 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ALDH4A1(1), CAD(1), CPS1(6), EPRS(2), GAD1(2), GFPT1(1), GFPT2(1), GLUD2(2), GLUL(1), GOT1(1), PPAT(3), QARS(1) 4087798 22 10 22 9 5 10 3 1 3 0 0.492 0.926 328 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IKBKB(2), IL1B(1), IL1R1(1), IL1RAP(1), IL1RN(1), IL6(1), IRAK3(2), MAP2K3(4), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK8(5), MYD88(1), NFKB1(3), TGFB2(4) 3068645 34 7 34 6 10 12 7 2 3 0 0.493 0.926 329 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(2), ACTN2(1), ACTN3(1), BCR(1), CAV1(1), CSK(2), FYN(1), GRB2(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MAPK8(5), PPP1R12B(4), RAF1(2), RAP1A(1), ROCK1(7), SOS1(2), TLN1(2), VCL(1), ZYX(1) 4902174 39 12 39 7 13 14 7 1 4 0 0.496 0.928 330 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ACCN1(1), ADCY8(1), CACNA1A(9), CACNA1B(4), GNAT3(1), ITPR3(1), KCNB1(3), PDE1A(1), PRKACA(1), PRKACG(1), SCNN1B(1), SCNN1G(3), TAS1R1(1), TAS1R2(2), TAS2R1(1), TAS2R10(3), TAS2R14(1), TAS2R16(2), TAS2R38(1), TAS2R39(1), TAS2R4(1), TAS2R46(1), TAS2R5(1), TAS2R50(1), TAS2R60(1), TAS2R7(1), TAS2R8(1), TAS2R9(2) 5892145 48 15 48 21 23 14 9 0 2 0 0.501 0.932 331 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(1), F3(1), F5(7), F7(1), FGA(2), FGB(1), PROS1(3), TFPI(3) 1676830 19 5 19 7 5 6 6 0 2 0 0.505 0.932 332 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD33(1), CD5(2), IL10(1), IL12A(1), ITGAX(2), TLR2(4), TLR4(3), TLR7(3), TLR9(3) 1925986 23 6 23 3 7 10 5 0 1 0 0.505 0.932 333 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(1), HADHA(1), HADHB(1) 871498 3 3 3 5 0 2 0 0 1 0 0.505 0.932 334 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(1), PRKCA(2), TGM2(2) 522622 6 3 6 2 3 3 0 0 0 0 0.507 0.932 335 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(2), ALDH3B1(1), EPX(1), ESCO1(4), ESCO2(1), GOT1(1), HPD(1), LPO(1), MAOA(1), MAOB(1), MPO(2), MYST3(5), MYST4(5), SH3GLB1(1), TAT(2), TPO(3) 3545939 32 10 32 12 10 14 5 0 3 0 0.509 0.932 336 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), ADRBK2(1), CAMK2D(1), CLCA1(2), CLCA2(3), CLCA4(1), CNGA3(1), CNGA4(1), GNAL(1), GUCA1A(1), GUCA1B(1), GUCA1C(1), PDE1C(2), PRKACA(1), PRKACG(1), PRKG1(5), PRKG2(2) 3204918 26 9 26 11 6 14 4 0 2 0 0.509 0.932 337 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(3), POLR1B(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(5), POLR3K(1) 2414568 19 8 19 3 8 8 2 0 1 0 0.510 0.932 338 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(1), MTMR2(1), TPK1(3) 663490 6 3 6 1 4 1 1 0 0 0 0.512 0.933 339 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ALAS1(1), ALAS2(1), BHMT(2), CBS(1), CHDH(1), CHKA(2), CTH(1), DAO(4), DLD(1), DMGDH(2), GCAT(1), GLDC(1), MAOA(1), MAOB(1), PISD(2), PSAT1(1), RDH11(1), RDH12(1), SARDH(1), SARS(1), SHMT1(1), TARS(3), TARS2(1) 4486547 32 12 32 14 13 14 3 0 2 0 0.514 0.935 340 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(4), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH4A1(1), AMD1(1), ARG2(1), ASL(2), CKM(1), CKMT2(3), CPS1(6), DAO(4), GOT1(1), MAOA(1), MAOB(1), NOS1(6), OAT(1), ODC1(3), OTC(1), P4HA1(1), P4HA3(1), RARS(2) 4528492 46 11 45 16 18 14 5 1 8 0 0.518 0.938 341 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1) 163366 1 1 1 0 0 0 1 0 0 0 0.521 0.938 342 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 FOS(1), GRB2(1), IL2(1), IL2RB(1), JAK1(1), JAK3(2), LCK(1), MAP2K1(1), MAPK3(1), MAPK8(5), RAF1(2), SOS1(2), STAT5B(1), SYK(3) 2444646 23 7 23 3 5 9 3 1 5 0 0.521 0.938 343 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), SUCLA2(2) 926068 3 3 3 5 0 2 0 0 1 0 0.522 0.938 344 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AGPAT1(1), AGPAT4(2), AKR1B1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKZ(1), LCT(5), LIPC(1), LIPF(2), PNLIP(2), PNLIPRP2(1) 4970369 38 12 38 14 15 12 6 0 5 0 0.525 0.940 345 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3B1(1), EPX(1), GOT1(1), HPD(1), LPO(1), MAOA(1), MAOB(1), MPO(2), PRDX1(1), TAT(2), TPO(3) 2286769 17 8 17 10 6 8 0 0 3 0 0.528 0.943 346 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT2(1), AKT3(1), ARHGEF11(2), CDC42(1), DLG4(1), LPA(1), MAP2K4(2), MAP3K1(2), MAP3K5(1), MAPK8(5), NFKB1(3), NFKB2(2), PDK1(2), PHKA2(1), PI3(1), PLD1(3), PLD2(1), RDX(1), ROCK1(7), ROCK2(4), SERPINA4(3) 5042120 45 11 45 11 17 15 5 1 7 0 0.531 0.944 347 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOC(2), FBP2(1), GOT1(1), ME1(2), ME3(1), PGK2(1), TKTL1(1), TKTL2(2) 2046293 11 7 11 11 6 3 1 0 1 0 0.532 0.944 348 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIT1(1), CMAS(3), CYB5R1(2), GFPT1(1), GFPT2(1), HEXB(2), HK3(1), LHPP(1), MTMR1(1), MTMR2(1), NANS(1), NPL(1), PGM3(1) 2977927 17 8 17 7 7 5 3 1 1 0 0.533 0.944 349 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPL13(1), RPL10A(1), RPL11(1), RPL19(1), RPL28(1), RPL6(2), RPL9(1), RPS15A(1), RPS16(1), RPS18(1), RPS2(1), RPS3(1) 2308987 14 7 14 4 0 5 7 1 1 0 0.536 0.946 350 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(1), FOS(1), GNAQ(1), MAPK8(5), PRKCA(2) 1390115 10 5 10 3 3 4 1 1 1 0 0.539 0.949 351 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 81 ANPEP(3), CD1A(1), CD1B(1), CD1C(1), CD1D(1), CD1E(1), CD22(2), CD33(1), CD38(1), CD5(2), CD55(1), CR1(3), CR2(2), CSF1(1), CSF3R(1), DNTT(2), FLT3(2), GP5(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), IL1B(1), IL1R1(1), IL1R2(4), IL5RA(2), IL6(1), IL6R(1), IL7(1), IL7R(1), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGAM(3), ITGB3(2), KIT(2), MME(4), TFRC(1), THPO(1), TPO(3) 8411864 67 18 67 28 22 31 10 1 3 0 0.543 0.954 352 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AP2A1(1), BTK(1), EEA1(4), GSK3B(1), PFKM(3), PRKCE(2), VAV2(2) 2641449 14 7 14 7 2 9 1 0 2 0 0.546 0.956 353 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(2), EPHB1(3), FYN(1), L1CAM(2), SELP(2) 1633073 11 5 11 6 5 4 1 0 1 0 0.549 0.956 354 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(2), CAPN2(1), EP300(2), NFATC1(1), NFATC2(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2) 2453746 14 8 14 5 7 4 1 0 2 0 0.551 0.956 355 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(3), FUT9(1), HEXB(2) 1024738 6 4 6 3 4 1 1 0 0 0 0.554 0.956 356 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C9(3) 208242 3 1 3 0 1 1 1 0 0 0 0.554 0.956 357 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(1), MAPK3(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1) 1316366 8 5 8 3 4 2 0 0 2 0 0.556 0.956 358 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTR2(1), ACTR3(1), CDC42(1), FLNA(1), FLNC(2), LIMK1(1), MYH2(3), MYLK(3), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), RHO(1), ROCK1(7), ROCK2(4), RPS4X(1), WASF1(2), WASL(2) 4901391 38 13 38 6 17 8 4 0 9 0 0.556 0.956 359 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ADRA1B(1), ADRB1(1), ANXA6(1), ATP1A4(2), ATP1B2(2), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(4), CACNA1A(9), CACNA1B(4), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1S(4), CACNB3(1), CALR(1), CAMK1(2), CAMK2D(1), CAMK4(1), CASQ1(1), CASQ2(3), CHRM2(3), CHRM4(1), CHRM5(1), GJA1(4), GJB3(1), GNAQ(1), GNG4(1), GNGT1(1), GRK5(1), ITPR1(8), ITPR2(6), ITPR3(1), KCNB1(3), KCNJ5(1), MIB1(3), MYCBP(1), NME7(2), PLCB3(1), PLN(1), PRKACA(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PRKD1(5), RGS17(1), RGS2(2), RGS20(1), RGS3(2), RGS4(1), RGS5(1), RGS7(2), RGS9(3), RYR1(6), RYR2(11), RYR3(11), SLC8A1(2), SLC8A3(3), USP5(1), YWHAH(1) 20062212 174 36 174 62 67 73 17 0 16 1 0.557 0.956 360 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 GOT1(1), TAT(2), TYR(1) 486294 4 2 4 2 1 2 0 0 1 0 0.561 0.959 361 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(1), ALAS1(1), ALAS2(1), CPOX(1), FECH(1), UROD(1) 801780 6 3 6 2 3 2 1 0 0 0 0.562 0.959 362 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(2), CCNE2(1), CDK4(1), CDKN1B(2), PRB1(1) 903444 7 4 7 3 1 1 1 0 4 0 0.571 0.972 363 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP4A(1), INPP4B(2), INPPL1(1), MINPP1(1), OCRL(4), PI4KA(4), PIK3C3(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIP5K1B(1), PIP5K1C(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCE1(2), PLCG2(4), PLCZ1(1), PTEN(4), SYNJ1(3), SYNJ2(1) 7738102 45 16 45 16 10 20 8 0 7 0 0.573 0.972 364 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ITGAL(3), ITGAM(3), ITGB2(1), PECAM1(1), SELE(2), SELL(3) 1193363 13 5 13 4 2 8 1 0 2 0 0.574 0.972 365 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALNT1(1), B3GALT5(2), FUT1(3), FUT9(1), HEXB(2) 1088001 9 4 9 4 6 1 2 0 0 0 0.579 0.976 366 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 CCKBR(2), CCR3(1), CELSR2(1), CHRM2(3), EMR2(4), EMR3(1), FSHR(1), GPR116(4), GPR133(1), GPR18(2), GPR56(1), GPR77(1), GPR84(3), GRM1(3), LPHN2(3), LPHN3(7), PTGFR(1), SMO(1), SSTR2(1), TAAR5(1), TSHR(1) 6770145 43 16 43 23 18 14 8 1 2 0 0.581 0.976 367 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(1), LARS(1), LARS2(1), PDHA1(1), PDHA2(2) 1039589 6 4 6 3 2 1 3 0 0 0 0.583 0.976 368 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 22 ACPP(1), ALPPL2(1), CYP3A43(2), CYP3A7(2), DHRS2(1), PON1(1), PON2(1) 1801057 9 5 9 4 3 4 1 0 0 1 0.586 0.976 369 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AKR1C4(1), AKR1D1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), HADHB(1), SRD5A2(1) 2430000 15 7 15 12 2 7 4 0 2 0 0.586 0.976 370 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK3(1), PGM1(2), PGM3(1), TGDS(1) 1053462 6 4 6 1 3 3 0 0 0 0 0.586 0.976 371 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT1(3), FUT9(1), GCNT2(2) 625550 6 3 6 3 4 1 0 0 1 0 0.588 0.976 372 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(4), EP300(2), IKBKB(2), IL1B(1), IL8(1), MAP2K3(4), MAP2K6(1), MAP3K14(1), MAP3K7(2), MYD88(1), NFKB1(3), NR3C1(1), TGFBR1(3), TLR2(4) 3079635 32 7 32 7 9 10 8 1 4 0 0.590 0.977 373 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), B4GALT1(1), G6PC(1), G6PC2(1), GALK2(1), GANC(1), GCK(1), HK3(1), LALBA(1), LCT(5), MGAM(4), PFKM(3), PGM1(2), PGM3(1), RDH11(1), RDH12(1), UGP2(2) 3995593 28 10 28 7 11 12 4 0 1 0 0.593 0.979 374 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(4), ACYP1(1), AKR1B1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), DLAT(1), DLD(1), GRHPR(1), LDHA(1), LDHB(2), ME1(2), ME3(1), PC(3), PCK1(3), PDHA1(1), PDHA2(2) 3819614 29 9 29 15 10 11 3 1 4 0 0.597 0.980 375 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(1), HEXB(2), LCT(5), SLC33A1(1), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(2), ST8SIA5(2) 1706350 15 6 15 5 7 6 2 0 0 0 0.598 0.980 376 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(3), G6PD(1), GPX3(2), GPX6(1), GSTA3(1), GSTA5(1), GSTM3(1), GSTO2(1), TXNDC12(2) 2235987 13 7 13 2 3 7 3 0 0 0 0.598 0.980 377 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CSF1(1), IL6(1), LDLR(1) 549324 3 2 3 2 3 0 0 0 0 0 0.607 0.990 378 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), IL2(1), TGFB2(4), TGFBR1(3), TGFBR3(3), TOB1(2) 1111347 14 4 14 2 3 5 3 0 3 0 0.609 0.990 379 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(3), AR(2), ESRRA(1), HNF4A(4), NPM1(1), NR0B1(1), NR1D2(3), NR1I3(1), NR2E1(1), NR2F1(1), NR2F6(1), NR3C1(1), NR4A2(2), PPARD(1), RARB(2), ROR1(4), RXRB(1), RXRG(1), VDR(1) 4301651 32 12 32 7 11 9 9 0 3 0 0.611 0.990 380 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(3), FOS(1), MAP2K1(1), MAPK3(1), NFKB1(3), PRKCA(2), RAF1(2) 1584282 13 4 13 5 7 2 2 0 2 0 0.611 0.990 381 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(1), MAP2K1(1), MAP2K2(1), MAPK3(1), NGFR(1), RAF1(2) 846885 7 3 7 2 3 1 2 0 1 0 0.618 0.996 382 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP3(1), CASP6(1), CFLAR(1), DAXX(1), DFFA(1), LMNB1(2), MAP2K4(2), MAP3K1(2), MAP3K7(2), MAPK8(5), PAK1(1), PAK2(1), PRKDC(5), PTPN13(9), RB1(3), SPTAN1(4) 4461213 41 10 41 9 9 13 9 1 9 0 0.620 0.996 383 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR2(1), ACTR3(1), ARPC2(1), NCK1(1), NCKAP1(1), PIR(1), PSMA7(1), WASF1(2), WASF3(2), WASL(2) 1606039 14 5 14 2 5 5 2 0 2 0 0.620 0.996 384 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), NFKB1(3), NSMAF(2), RAF1(2) 2138165 18 6 18 8 7 6 2 1 2 0 0.621 0.996 385 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(4), ACACB(1), ACADM(3), ACSS2(1), ALDH1A3(2), ALDH1B1(2), ALDH6A1(1), ALDH7A1(2), HADHA(1), HIBCH(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), LDHB(2), MCEE(1), MUT(1), PCCA(6), PCCB(1), SUCLA2(2), SUCLG1(1) 4114672 35 10 35 7 8 14 4 0 9 0 0.623 0.996 386 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 TGDS(1), UGDH(1), UXS1(1) 419210 3 2 3 0 0 2 0 0 1 0 0.628 1.000 387 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1B2(1), EEF2K(1), EIF2AK1(1), EIF2AK2(1), EIF2AK3(1), EIF2B2(1), EIF4A2(1), EIF4EBP2(1), EIF4G1(1), EIF4G3(3), EIF5A(1), ETF1(3), PABPC3(2), PAIP1(3) 4583750 21 10 21 6 5 7 4 1 4 0 0.629 1.000 388 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 HADHA(1), HSD17B10(1), SIRT1(1), SIRT2(1), SIRT5(2), VNN2(1) 1217545 7 4 7 4 1 2 1 0 3 0 0.631 1.000 389 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2F1(2), GTF2F2(1), GTF2H1(2), GTF2IRD1(1), TAF1(5), TAF1L(6), TAF2(2), TAF4(1), TAF4B(2), TAF5(1), TAF5L(1), TAF6(1), TAF7(1), TAF7L(1), TAF9(1) 3726636 28 9 28 3 7 9 5 0 7 0 0.636 1.000 390 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), ITGAL(3), ITGB2(1), PTPRC(8) 1103542 13 4 13 5 3 6 1 0 3 0 0.637 1.000 391 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 CSF1(1), FCGR3A(1), IL1B(1), IL6R(1), SELL(3), SPN(1), TGFB2(4), TNFRSF8(1) 1417332 13 5 13 4 3 4 3 0 3 0 0.646 1.000 392 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(1), BLNK(1), FOS(1), GRB2(1), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8IP3(1), PAPPA(5), RPS6KA3(2), SOS1(2), SYK(3), VAV1(2), VAV2(2), VAV3(2) 3281130 28 9 28 3 8 15 2 0 3 0 0.647 1.000 393 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 CASP3(1), CRADD(1), DFFA(1), LMNB1(2), MADD(1), MAP2K4(2), MAP3K1(2), MAP3K7(2), MAPK8(5), PAK1(1), PAK2(1), PRKDC(5), RB1(3), SPTAN1(4) 4139843 31 10 31 10 10 6 7 1 7 0 0.649 1.000 394 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F13B(2), F2(1), F5(7), F7(1), F8(3), FGA(2), FGB(1), LPA(1), PLAT(1), PLAU(1), PLG(2), SERPINB2(1), SERPINE1(2), VWF(5) 3612160 30 9 30 13 10 13 4 0 3 0 0.650 1.000 395 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), UGDH(1), UGP2(2), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2) 2589488 19 6 19 2 2 11 3 0 3 0 0.653 1.000 396 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACPP(1), ENPP3(1), LHPP(1), MTMR1(1), MTMR2(1), TYR(1) 1562482 6 4 6 6 4 1 0 0 0 1 0.656 1.000 397 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), ITGAL(3), ITGB2(1), PTPRC(8) 1165152 13 4 13 5 3 6 1 0 3 0 0.657 1.000 398 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), TAT(2) 272049 3 1 3 1 0 2 0 0 1 0 0.657 1.000 399 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLAT(1), DLD(1), DLST(1), IDH3A(3), PC(3), PDHA1(1), PDHA2(2), PDK1(2), PDK2(1), PDK3(1), PDK4(1), PDP2(1), SDHA(1), SUCLA2(2), SUCLG1(1) 2969819 22 8 22 11 7 8 4 0 3 0 0.657 1.000 400 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT1(1), B4GALT3(1), FUT8(1) 809447 3 3 3 2 1 1 0 0 1 0 0.660 1.000 401 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ITGA4(5), ITGAL(3), ITGB2(1), PECAM1(1), SELE(2), SELL(3) 1350187 15 4 15 3 1 9 3 0 2 0 0.661 1.000 402 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CSF1(1), IL2(1), IL6(1), IL7(1), IL8(1), IL9(1) 649225 6 2 6 4 2 4 0 0 0 0 0.662 1.000 403 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 LCT(5), PGM1(2), PYGM(2) 1408399 9 5 9 2 8 1 0 0 0 0 0.665 1.000 404 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(1), JAK1(1), JAK2(3) 1084914 6 3 6 3 1 3 0 0 1 1 0.667 1.000 405 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(1), JAK1(1), JAK2(3) 1084914 6 3 6 3 1 3 0 0 1 1 0.667 1.000 406 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 SDHA(1), SUCLA2(2) 979996 3 3 3 4 0 3 0 0 0 0 0.667 1.000 407 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2B(3), POLR2K(1) 1372058 6 4 6 1 3 2 1 0 0 0 0.667 1.000 408 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GNS(3), HEXB(2), LCT(5), NAGLU(1) 1505826 11 5 11 3 5 4 1 0 1 0 0.676 1.000 409 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 SHMT1(1) 446940 1 1 1 1 0 1 0 0 0 0 0.679 1.000 410 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 GRIA2(3) 390132 3 2 3 2 1 0 2 0 0 0 0.683 1.000 411 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(2), FUCA1(2), HEXB(2), LCT(5), MAN2B1(1), MANBA(1), NEU1(1) 2085183 14 6 14 6 6 4 1 0 3 0 0.683 1.000 412 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT2(1), AKT3(1), BCR(1), BTK(1), DAPP1(1), ITPR1(8), ITPR2(6), ITPR3(1), PDK1(2), PIK3CA(7), PLCG2(4), PPP1R13B(1), PREX1(2), PTEN(4), PTPRC(8), RPS6KA2(2), RPS6KA3(2), SYK(3), TEC(2), VAV1(2) 5793156 59 12 59 11 18 22 8 0 10 1 0.684 1.000 413 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 CSAD(1), GAD1(2) 599279 3 2 3 3 1 2 0 0 0 0 0.684 1.000 414 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), CARS(1), DARS(1), DARS2(1), EPRS(2), FARS2(1), FARSB(1), HARS2(2), IARS(1), LARS(1), LARS2(1), MARS(3), MARS2(1), MTFMT(1), NARS(1), NARS2(3), QARS(1), RARS(2), RARS2(2), SARS(1), TARS(3), TARS2(1), WARS(1), WARS2(1), YARS2(1) 5494247 35 11 35 10 7 16 8 1 3 0 0.688 1.000 415 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK3(1), PGM1(2), PGM3(1), TGDS(1) 1193575 6 4 6 1 3 3 0 0 0 0 0.691 1.000 416 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), DHFR(1), MTHFD1L(2), MTHFR(1), MTR(1), SHMT1(1), TYMS(1) 1866340 10 5 10 4 4 5 0 0 1 0 0.691 1.000 417 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(3), CASP3(1), GZMB(1) 1332071 6 4 6 1 0 1 3 0 2 0 0.691 1.000 418 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ARG2(1), ASL(2), CKM(1), CKMT2(3), CPS1(6), NAGS(1), OAT(1), ODC1(3), OTC(1) 1797467 19 5 19 4 8 5 3 0 3 0 0.693 1.000 419 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 247 ACVR1(1), ACVR1B(2), ACVR2A(1), ACVR2B(1), BMP2(1), BMP7(1), BMPR1B(1), BMPR2(3), CCL18(1), CCL22(1), CCR3(1), CCR4(1), CCR7(2), CCR9(2), CD40(1), CSF1(1), CSF3R(1), CX3CL1(1), CX3CR1(1), CXCL10(1), CXCL11(1), CXCL14(1), CXCL16(1), CXCL5(1), CXCL9(1), CXCR4(1), EDA(1), EDAR(2), EGFR(1), FAS(2), FLT1(3), FLT3(2), FLT4(1), GDF5(1), GH1(1), GH2(2), HGF(3), IFNA10(2), IFNA2(1), IFNAR2(1), IFNGR1(1), IFNGR2(1), IFNK(1), IL10(1), IL10RA(1), IL10RB(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL17A(1), IL17RA(1), IL18R1(2), IL18RAP(2), IL1B(1), IL1R1(1), IL1R2(4), IL1RAP(1), IL2(1), IL20(1), IL20RA(1), IL21R(2), IL23R(1), IL2RB(1), IL5RA(2), IL6(1), IL6R(1), IL6ST(1), IL7(1), IL7R(1), IL8(1), IL9(1), INHBA(2), INHBC(1), INHBE(1), KDR(2), KIT(2), LEPR(4), LIFR(5), LTBR(1), MET(1), MPL(1), NGFR(1), OSMR(2), PDGFC(1), PDGFRA(4), PDGFRB(1), PRL(1), PRLR(2), TGFB2(4), TGFBR1(3), TNFRSF10B(4), TNFRSF10D(1), TNFRSF11A(1), TNFRSF21(1), TNFRSF8(1), TNFRSF9(1), TNFSF13B(1), TPO(3), VEGFC(3), XCR1(1) 18006642 148 28 148 46 36 63 26 1 21 1 0.693 1.000 420 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(3), G6PD(1), GPX3(2), GSTA3(1), GSTM3(1), GSTO2(1) 1866994 9 5 9 2 2 5 2 0 0 0 0.695 1.000 421 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(3), CLOCK(3), CRY1(3), CSNK1D(1), PER3(2) 1770505 12 5 12 1 2 3 3 0 3 1 0.700 1.000 422 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 TGDS(1), UGDH(1), UGP2(2), UXS1(1) 527333 5 2 5 0 0 3 1 0 1 0 0.704 1.000 423 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ADSS(1), ASL(2), ASPA(2), CAD(1), DARS(1), GAD1(2), GOT1(1), NARS(1), PC(3) 2707382 15 6 15 11 7 5 2 0 1 0 0.704 1.000 424 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(2), CDK4(1), CDKN1B(2), RB1(3), RBL1(2) 1652652 10 5 10 3 3 1 2 0 4 0 0.705 1.000 425 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(2), POLE(4), POLG(1), POLL(1), POLQ(4) 1761784 12 5 11 5 2 4 3 0 3 0 0.708 1.000 426 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 FDFT1(1), HMGCR(1), LSS(1), NQO2(1), SC5DL(2), SQLE(1) 1162243 7 4 7 2 3 1 3 0 0 0 0.711 1.000 427 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(2), ATF2(1), EGFR(1), GNAQ(1), GRB2(1), MAP2K1(1), MAP2K2(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), MEF2A(1), MEF2C(2), PAK1(1), PRKCA(2), RAF1(2), SOS1(2) 3536762 29 8 29 4 7 11 5 1 5 0 0.712 1.000 428 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), B4GALT1(1), B4GALT3(1), DPAGT1(1), FUT8(1), MAN1A1(1), MGAT1(1), RPN2(1) 2009446 8 5 8 7 2 2 1 0 3 0 0.713 1.000 429 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(1), EPHB2(1), F2(1), F2RL1(1), F2RL2(1), MAP2K5(2), MAPK8(5), PLD1(3), PLD2(1), RAF1(2), RASAL1(1), TEC(2), VAV1(2) 2892926 24 7 24 6 10 8 4 1 1 0 0.716 1.000 430 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(1), ACSL6(1), ADIPOR2(1), AKT2(1), AKT3(1), CHUK(2), CPT1A(1), CPT2(1), G6PC(1), G6PC2(1), IKBKB(2), IRS1(3), IRS4(4), JAK1(1), JAK2(3), JAK3(2), LEPR(4), MAPK10(4), MAPK8(5), MAPK9(2), NFKB1(3), NFKB2(2), NPY(1), PCK1(3), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1), PRKAG3(2), PRKCQ(1), PTPN11(3), RXRB(1), RXRG(1), SLC2A1(1), SLC2A4(1) 8446597 66 16 66 16 19 26 7 2 11 1 0.723 1.000 431 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), DHFR(1), MTFMT(1), MTHFD1L(2), MTHFR(1), MTR(1), SHMT1(1), TYMS(1) 1964714 11 5 11 4 4 6 0 0 1 0 0.727 1.000 432 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAP3K14(1), MAPK8(5), NFKB1(3), TNFSF13B(1), TRAF3(2), TRAF5(2) 1528752 16 4 16 4 4 5 4 1 2 0 0.729 1.000 433 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(3), CD38(1), ENPP3(1), NADK(1), NMNAT1(1), NMNAT2(1), NNMT(2), NNT(2), NT5C1B(1), NT5C2(1), NT5E(1) 2251735 15 6 15 7 5 5 2 0 3 0 0.729 1.000 434 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSS(1), DHFR(1), IMPDH1(1), POLB(2), POLG(1), RRM1(1) 1334227 7 4 7 3 4 1 1 0 1 0 0.729 1.000 435 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2) 1389687 11 4 11 5 1 5 3 0 2 0 0.730 1.000 436 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(1), DLL1(3), FURIN(1) 858391 5 3 5 1 2 0 0 0 3 0 0.731 1.000 437 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(1), IL1B(1) 629855 2 2 2 3 2 0 0 0 0 0 0.732 1.000 438 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 HMGCL(1), HMGCS2(1) 751997 2 2 2 2 2 0 0 0 0 0 0.736 1.000 439 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), HLA-DRA(1), HLA-DRB1(1) 224517 3 1 3 0 2 1 0 0 0 0 0.737 1.000 440 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GNS(3), HEXB(2), HPSE2(3), LCT(5), NAGLU(1), SPAM1(3) 2148768 17 6 17 4 8 6 2 0 1 0 0.739 1.000 441 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 CA3(1), CA5A(1), CA8(1), CPS1(6), CTH(1), GLUD2(2), GLUL(1), HAL(1) 2182587 14 5 14 6 4 8 0 0 2 0 0.741 1.000 442 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(1), AMY2A(2), AMY2B(1), ASCC3(5), DDX18(1), DDX19A(1), DDX4(1), DDX50(1), DDX52(1), DDX55(1), DDX56(2), DHX58(1), ENPP3(1), EP400(2), ERCC3(1), G6PC(1), G6PC2(1), GANC(1), GBE1(1), GCK(1), GPI(1), GYS1(1), GYS2(3), HK3(1), MGAM(4), MOV10L1(7), PGM1(2), PGM3(1), PYGM(2), RAD54B(2), SETX(9), SI(3), SKIV2L2(1), SMARCA2(2), SMARCA5(4), UGDH(1), UGP2(2), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2), UXS1(1) 12753461 89 21 89 17 22 30 18 0 19 0 0.741 1.000 443 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACPP(1), ENPP3(1), TYR(1) 1011230 3 2 3 5 1 1 0 0 0 1 0.741 1.000 444 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNAQ(1), GNGT1(1), HTR2C(2), TUB(1) 738892 5 2 5 2 1 2 1 0 1 0 0.746 1.000 445 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AKR1C2(1), AKR1C3(2), AKR1C4(1), ALDH1A3(2), ALDH3B1(1), CYP1A1(1), CYP1A2(1), CYP1B1(1), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP3A43(2), CYP3A7(2), GSTA3(1), GSTA5(1), GSTM3(1), GSTO2(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2) 5727549 47 11 47 12 8 18 14 0 7 0 0.747 1.000 446 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 FOS(1), GRB2(1), JAK2(3), MAP2K1(1), MAPK3(1), RAF1(2), SOS1(2), STAT5B(1) 1761812 12 4 12 2 3 4 2 0 2 1 0.749 1.000 447 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10B(3), ALG14(1), ALG5(1), ALG8(1), ALG9(1), B4GALT1(1), B4GALT3(1), DHDDS(1), DPAGT1(1), FUT8(1), MAN1A1(1), MAN1C1(3), MAN2A1(4), MGAT1(1), RPN2(1), STT3B(2) 4383801 25 8 25 11 7 9 5 0 4 0 0.752 1.000 448 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST1(1), HS3ST2(2), XYLT1(2) 680113 6 2 6 1 3 1 0 1 1 0 0.759 1.000 449 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST1(1), HS3ST2(2), XYLT1(2) 680113 6 2 6 1 3 1 0 1 1 0 0.759 1.000 450 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 ETV5(1), IL12A(1), IL12RB2(1), IL18R1(2), JAK2(3), MAP2K6(1), MAPK8(5), STAT4(3) 1926374 17 4 17 3 1 8 4 1 2 1 0.760 1.000 451 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(1), CHST12(1), CHST13(1), PAPSS1(1), PAPSS2(2), SULT1E1(1), SULT2A1(1) 945861 8 3 8 2 1 5 2 0 0 0 0.761 1.000 452 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALNT1(1), B3GALT5(2), B3GNT2(1), B3GNT3(1), B4GALNT1(1), B4GALT1(1), B4GALT3(1), FUT1(3), FUT3(1), FUT9(1), GCNT2(2), PIGB(1), PIGG(2), PIGK(1), PIGM(2), PIGN(1), PIGO(1), PIGT(1), PIGU(1), PIGV(2), PIGX(2), ST3GAL6(3), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(2), ST8SIA5(2) 5024214 38 10 38 14 12 17 6 1 2 0 0.762 1.000 453 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACO1(1), ACSS2(1), SUCLA2(2) 1377449 4 3 4 6 0 3 0 0 1 0 0.766 1.000 454 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 IL8(1) 175407 1 1 1 0 0 1 0 0 0 0 0.769 1.000 455 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(1), IFNAR2(1), MAPK8(5), NFKB1(3), TNFRSF11A(1) 1137337 12 3 12 3 5 5 1 1 0 0 0.769 1.000 456 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 SHMT1(1) 597755 1 1 1 2 0 1 0 0 0 0 0.771 1.000 457 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(1), FOS(1), FYN(1), THBS1(2) 759323 5 2 5 1 2 2 1 0 0 0 0.776 1.000 458 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 DEGS1(1), ENPP7(1), GAL3ST1(2), LCT(5), NEU1(1), SGMS1(1), SGMS2(2), SGPP1(2), SGPP2(2), SPHK1(1), UGT8(2) 3609863 20 8 20 8 10 5 2 0 2 1 0.776 1.000 459 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOC(2), FBP2(1), GOT1(1), ME1(2), ME3(1) 1828269 7 4 7 8 5 1 0 0 1 0 0.777 1.000 460 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(2), IKBKB(2), MAP3K1(2), MAP3K14(1), NFKB1(3), TNFAIP3(1), TRAF3(2) 1906657 13 5 13 3 3 7 2 0 1 0 0.777 1.000 461 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(1), ESRRA(1), HDAC5(1), MEF2A(1), MEF2C(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), SLC2A4(1), YWHAH(1) 2161965 17 5 17 6 7 7 0 0 3 0 0.777 1.000 462 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 CABIN1(2), CAMK4(1), CD69(1), CNR1(2), CREBBP(4), CTLA4(1), EGR2(2), EP300(2), FCER1A(1), FCGR3A(1), FOS(1), GRLF1(5), GSK3B(1), IL10(1), IL1B(1), IL2(1), IL6(1), IL8(1), ITK(3), MAPK8(5), MAPK9(2), MEF2A(1), MYF5(2), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB2(2), NPPB(1), NUP214(2), P2RX7(1), PAK1(1), PPP3CB(1), PPP3CC(1), PTPRC(8), SP3(1), TRPV6(2), VAV1(2), VAV2(2), VAV3(2), XPO5(1) 9385994 74 17 74 23 29 25 8 1 11 0 0.779 1.000 463 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 IL12A(1), IL12RB2(1), JAK2(3), STAT4(3) 1520373 8 3 8 2 0 3 3 0 1 1 0.780 1.000 464 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ALDOC(2), DLAT(1), DLD(1), ENO3(1), FBP2(1), G6PC(1), GCK(1), GPI(1), HK3(1), LDHA(1), LDHB(2), PDHA1(1), PDHA2(2), PFKM(3), PGM1(2), PGM3(1) 5023122 34 10 34 17 11 12 7 0 4 0 0.782 1.000 465 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ALDOC(2), DLAT(1), DLD(1), ENO3(1), FBP2(1), G6PC(1), GCK(1), GPI(1), HK3(1), LDHA(1), LDHB(2), PDHA1(1), PDHA2(2), PFKM(3), PGM1(2), PGM3(1) 5023122 34 10 34 17 11 12 7 0 4 0 0.782 1.000 466 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 FYN(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PTPRC(8) 921740 12 3 12 1 3 6 1 0 2 0 0.787 1.000 467 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(1) 301230 1 1 1 0 1 0 0 0 0 0 0.788 1.000 468 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT2(1), GALNT6(1), GALNT7(1), GALNT8(1), GCNT1(2), WBSCR17(2) 1489580 8 3 8 3 3 3 2 0 0 0 0.791 1.000 469 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(1), DIAPH2(3), MCM10(2), MCM3(2), MCM5(3), MCM6(1), MCM7(1), PCNA(1), POLE(4), POLE2(1), RFC1(4), RFC5(1), RPA4(1), UBB(1) 5280323 27 10 26 8 7 16 1 0 3 0 0.792 1.000 470 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CHUK(2), EGR2(2), GNAQ(1), MAP3K1(2), NFATC1(1), NFATC2(2), NFKB1(3), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1) 2811350 23 7 23 8 12 7 1 0 3 0 0.794 1.000 471 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 ACYP1(1), DHRS2(1), ESCO1(4), ESCO2(1), GCDH(2), HADHA(1), MYST3(5), MYST4(5), SH3GLB1(1) 2629022 21 6 21 7 6 7 6 0 2 0 0.794 1.000 472 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), UCHL1(1), UCHL3(1), UGDH(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1) 1680451 9 4 9 1 2 5 0 0 2 0 0.795 1.000 473 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(3), PRKCA(2) 856733 6 2 6 4 4 1 0 0 1 0 0.796 1.000 474 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP4A11(1), CYP4F3(1), GPX3(2), GPX6(1), PLA2G4A(3), PLA2G6(2), PTGIS(1), PTGS1(2), PTGS2(1) 4074909 24 9 24 9 11 6 5 0 2 0 0.797 1.000 475 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(1), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL5RA(2), IL6(1) 530187 7 2 7 3 4 3 0 0 0 0 0.799 1.000 476 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), UGDH(1) 882392 7 3 7 1 1 3 1 0 2 0 0.805 1.000 477 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRB(1), IL10(1), IL10RA(1), IL10RB(1), IL6(1), JAK1(1) 1250523 6 3 6 2 2 2 0 0 2 0 0.806 1.000 478 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(1), AMY2A(2), AMY2B(1), ENPP3(1), G6PC(1), GBE1(1), GCK(1), GPI(1), GYS1(1), GYS2(3), HK3(1), MGAM(4), PGM1(2), PGM3(1), PYGM(2), SI(3), UCHL1(1), UCHL3(1), UGDH(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1), UXS1(1) 5829365 35 10 35 10 10 12 6 0 7 0 0.808 1.000 479 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(1), IFNGR2(1), JAK1(1), JAK2(3) 854289 6 2 6 1 1 2 0 0 2 1 0.810 1.000 480 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(1), DAXX(1), GRB2(1), HSPB2(1), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K5(1), MAP3K7(2), MAP3K9(2), MEF2A(1), MEF2C(2), PLA2G4A(3), RPS6KA5(3), TGFB2(4), TGFBR1(3) 3841159 31 8 31 9 10 9 5 0 7 0 0.813 1.000 481 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(3), CR2(2), HLA-DRA(1), HLA-DRB1(1), ITGAL(3), ITGB2(1), PTPRC(8) 1555123 20 4 20 6 4 10 3 0 3 0 0.813 1.000 482 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA3(1), PSMA7(1), PSMB3(1), PSMD1(4), PSMD12(2), PSMD13(1), PSMD2(1), PSMD6(1) 1663407 12 3 12 0 5 5 1 0 1 0 0.816 1.000 483 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO3(1), FARS2(1), GOT1(1), TAT(2) 856962 5 2 5 2 0 3 0 0 2 0 0.817 1.000 484 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), WASF1(2), WASL(2) 849834 9 2 9 1 4 1 2 0 2 0 0.817 1.000 485 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ANKRD1(2), IFRD1(3), IL1R1(1), MYOG(1), NR4A3(2) 1143542 9 3 9 1 4 3 1 0 1 0 0.819 1.000 486 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(1), HLA-DRA(1), HLA-DRB1(1) 285259 3 1 3 2 2 1 0 0 0 0 0.820 1.000 487 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 FOS(1), GRB2(1), JAK2(3), MAP2K1(1), MAPK3(1), MAPK8(5), RAF1(2), SOS1(2), STAT5B(1) 2252124 17 5 17 2 4 6 3 1 2 1 0.820 1.000 488 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 GREB1(2), HSPB2(1), MTA3(1), TUBA8(1) 1100771 5 3 5 2 2 2 1 0 0 0 0.820 1.000 489 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(1), CAD(1), CPS1(6), EPRS(2), GAD1(2), GFPT1(1), GLUL(1), GOT1(1), PPAT(3), QARS(1) 3428010 19 7 19 6 5 8 3 0 3 0 0.827 1.000 490 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA3(1), PSMA7(1), PSMB3(1), PSMD14(1), RPN2(1), UBE3A(5) 1357020 10 3 10 1 2 6 2 0 0 0 0.828 1.000 491 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CSF1(1), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL12A(1), IL2(1), IL6(1), IL7(1), IL8(1), TGFB2(4) 1350769 13 3 13 5 3 8 1 0 1 0 0.830 1.000 492 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADSS(1), AK2(1), AK5(1), ALLC(2), AMPD1(2), AMPD2(1), AMPD3(1), ATP5A1(3), ATP5C1(2), DCK(1), ENPP3(1), GUCY1A2(4), GUCY1A3(5), GUCY1B3(2), GUCY2C(1), GUCY2D(4), GUCY2F(4), IMPDH1(1), IMPDH2(3), NPR2(1), NT5E(1), PAICS(1), PAPSS1(1), PAPSS2(2), PDE1A(1), PDE4B(3), PDE4D(1), PDE5A(3), PDE6C(2), PDE7B(1), PDE9A(1), POLB(2), POLE(4), POLG(1), POLL(1), POLQ(4), POLR1B(2), POLR2B(3), POLR2K(1), PPAT(3), PRPS1(1), PRUNE(1), RRM1(1) 13427681 96 24 95 31 31 34 15 0 16 0 0.832 1.000 493 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP3(1), CFLAR(1) 394525 2 1 2 0 0 1 1 0 0 0 0.833 1.000 494 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(3), EGFR(1), GRB2(1), MAP2K1(1), MAPK3(1), RAF1(2), RASA1(4), SOS1(2), SPRY1(1) 2545826 16 4 16 6 7 4 3 0 2 0 0.833 1.000 495 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(4), ACACB(1), ACOT12(3), ACSS2(1), ACYP1(1), AKR1B1(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), DLAT(1), DLD(1), GRHPR(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), LDHB(2), ME1(2), ME3(1), PC(3), PCK1(3), PDHA1(1), PDHA2(2) 4833706 37 9 37 14 10 16 4 1 6 0 0.833 1.000 496 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSB(1), GOT1(1), TAT(2), YARS2(1) 902256 6 2 6 2 0 5 0 0 1 0 0.836 1.000 497 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1B(1), BMPR2(3) 643831 4 2 4 1 1 1 2 0 0 0 0.841 1.000 498 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), SQLE(1) 347094 2 1 2 0 0 1 1 0 0 0 0.841 1.000 499 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(1), ALAS1(1), ALAS2(1), FECH(1), GATA1(1), HBB(1), UROD(1) 853818 7 3 7 1 3 4 0 0 0 0 0.844 1.000 500 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(1), SOS1(2) 912443 3 2 3 1 0 2 1 0 0 0 0.845 1.000 501 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 CYP1A2(1), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP3A43(2), CYP3A7(2), PLA2G4A(3), PLA2G6(2), RDH11(1), RDH12(1) 2487146 20 5 20 6 9 4 5 0 2 0 0.847 1.000 502 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), AKT2(1), AKT3(1), ARHGAP5(3), BIRC2(2), BIRC3(5), BRAF(2), CAPN2(1), CAV1(1), CAV3(1), CDC42(1), CHAD(1), COL11A1(6), COL11A2(1), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(1), COL4A4(2), COL5A1(2), COL5A2(3), COL5A3(5), COL6A2(1), COL6A3(12), COL6A6(5), CTNNB1(4), DOCK1(2), EGFR(1), ERBB2(4), FIGF(2), FLNA(1), FLNB(2), FLNC(2), FLT1(3), FN1(4), FYN(1), GRB2(1), GRLF1(5), GSK3B(1), HGF(3), IGF1R(1), ITGA10(4), ITGA11(2), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAV(4), ITGB3(2), ITGB4(1), ITGB5(1), ITGB8(1), KDR(2), LAMA1(2), LAMA2(3), LAMA3(6), LAMA4(2), LAMB2(3), LAMB4(4), LAMC1(4), LAMC2(3), LAMC3(2), MAP2K1(1), MAPK10(4), MAPK3(1), MAPK8(5), MAPK9(2), MET(1), MYL9(2), MYLK(3), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PDGFC(1), PDGFRA(4), PDGFRB(1), PGF(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PIP5K1C(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PRKCA(2), PRKCG(2), PTEN(4), RAF1(2), RAP1A(1), RAPGEF1(2), RELN(9), RHOA(1), ROCK1(7), ROCK2(4), SHC2(1), SOS1(2), SOS2(2), THBS1(2), THBS2(5), THBS3(1), THBS4(1), TLN1(2), TLN2(3), TNC(3), TNN(2), TNR(2), TNXB(3), VAV1(2), VAV2(2), VAV3(2), VCL(1), VEGFC(3), VTN(3), VWF(5), ZYX(1) 38395148 303 44 301 114 108 105 45 4 38 3 0.847 1.000 503 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(1), ATG5(1), BECN1(1), IFNA10(2), IFNA2(1), PIK3C3(2), PRKAA1(1), PRKAA2(3), ULK1(1) 2158174 13 4 13 3 3 5 2 0 3 0 0.850 1.000 504 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(1), RAB9A(1) 449053 3 1 3 0 1 1 0 0 1 0 0.851 1.000 505 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP6(1), DFFA(1) 1413104 11 3 11 1 3 4 1 0 3 0 0.852 1.000 506 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), DDX20(1), ETS1(1), ETS2(1), ETV3(1), FOS(1), HDAC5(1), RBL1(2), SIN3A(6), SIN3B(1) 2745639 16 5 16 9 7 7 2 0 0 0 0.856 1.000 507 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR2(1), JAK1(1), STAT2(2) 1117513 4 2 4 2 1 2 0 0 1 0 0.857 1.000 508 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(4), ACACB(1), OXSM(1) 1546745 6 4 6 3 3 1 0 0 2 0 0.858 1.000 509 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(1), CTH(1), GOT1(1), LDHA(1), LDHB(2) 693110 6 2 6 2 2 3 0 0 1 0 0.858 1.000 510 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(1), JAK1(1), JAK2(3), JAK3(2), STAT5B(1) 1918838 8 4 8 3 0 4 0 0 3 1 0.863 1.000 511 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(1), CAMK2D(1), F2(1), FYN(1), GNAI1(1), GNGT1(1), GRB2(1), JAK2(3), MAP2K1(1), MAP2K2(1), MAPK3(1), MAPK8(5), MAPT(1), MYLK(3), PRKCA(2), RAF1(2), SOS1(2) 4357168 29 8 29 10 7 13 5 1 2 1 0.864 1.000 512 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(2), COL4A2(1), COL4A3(1), COL4A4(2), COL4A5(2), SLC23A2(1), SLC2A1(1) 2688954 10 5 10 5 4 3 0 0 3 0 0.867 1.000 513 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 GPI(1) 905773 1 1 1 4 0 0 1 0 0 0 0.867 1.000 514 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ6(1) 432408 2 1 2 0 0 1 1 0 0 0 0.869 1.000 515 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPPL2(1), ASCC3(5), DDX18(1), DDX19A(1), DDX4(1), DDX50(1), DDX52(1), DDX55(1), DDX56(2), DHFR(1), DHX58(1), EP400(2), ERCC3(1), MOV10L1(7), RAD54B(2), SETX(9), SKIV2L2(1), SMARCA2(2), SMARCA5(4) 6552695 44 12 44 4 12 13 8 0 11 0 0.872 1.000 516 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOC(2), FBP2(1), FPGT(2), GCK(1), GMPPA(1), HK3(1), PFKFB1(1), PFKM(3), PMM1(2), SORD(2) 2512407 17 6 17 3 6 9 2 0 0 0 0.872 1.000 517 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CSNK1D(1), GSK3B(1), MAPT(1) 981430 4 2 4 4 3 1 0 0 0 0 0.873 1.000 518 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 FLT3(2), IL6(1), IL9(1), TGFB2(4) 879053 8 2 8 5 1 5 1 0 1 0 0.875 1.000 519 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(1), GSK3B(1) 1196839 3 2 3 2 0 3 0 0 0 0 0.876 1.000 520 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 IL12A(1), IL2(1) 316089 2 1 2 1 0 2 0 0 0 0 0.880 1.000 521 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD80(1), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL2(1) 390117 6 1 6 0 2 4 0 0 0 0 0.882 1.000 522 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(1), APOBEC3F(1), APOBEC3G(1), APOBEC4(2) 761460 5 2 5 2 2 2 1 0 0 0 0.883 1.000 523 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 25 ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), CYP2C9(3), DHRS2(1), ESCO1(4), ESCO2(1), HADHA(1), MYST3(5), MYST4(5), SH3GLB1(1) 3151963 27 6 27 7 7 10 7 0 3 0 0.884 1.000 524 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(3), GCK(1), GFPT1(1), HEXB(2), HK3(1), PGM3(1) 1765852 9 3 9 1 2 5 2 0 0 0 0.887 1.000 525 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST6GALNAC2(1), ST6GALNAC4(1) 583702 2 2 2 2 0 2 0 0 0 0 0.887 1.000 526 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX3(2), FADS2(1), HADHA(1) 1394068 4 4 4 6 2 1 0 0 1 0 0.891 1.000 527 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), ADSS(1), ASL(2), ASPA(2), ASS1(1), CAD(1), DARS(1), DARS2(1), DLAT(1), DLD(1), GAD1(2), GOT1(1), NARS(1), NARS2(3), PC(3), PDHA1(1), PDHA2(2) 3938694 25 7 25 15 12 7 4 0 2 0 0.891 1.000 528 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(2), IKBKB(2), MAP3K1(2), MAP3K14(1), NFKB1(3), TANK(3), TNFAIP3(1), TRAF1(1), TRAF3(2) 2341968 17 5 17 5 6 7 3 0 1 0 0.891 1.000 529 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(1) 1213896 6 2 6 2 1 4 0 0 1 0 0.892 1.000 530 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(2), PRKACG(1), PRKAR2B(1) 1049906 4 3 4 2 2 1 0 0 1 0 0.892 1.000 531 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDC25C(1), XPO1(1) 900622 2 2 2 2 1 1 0 0 0 0 0.894 1.000 532 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 GRB2(1), IRS1(3), JAK1(1), JAK3(2) 1518907 7 3 7 2 1 3 1 0 2 0 0.894 1.000 533 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BCL2A1(3), CASP3(1), CASP4(2), CASP6(1), CD40(1), CRADD(1), DAXX(1), DFFA(1), FAS(2), IKBKE(1), NFKB1(3), NGFR(1), NR3C1(1), PTPN13(9), TRAF1(1), TRAF3(2) 4580192 32 8 32 13 7 12 7 0 6 0 0.897 1.000 534 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 FDFT1(1), HMGCR(1), LSS(1), SC4MOL(1), SC5DL(2), SQLE(1) 1384980 7 3 7 3 3 2 2 0 0 0 0.897 1.000 535 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(3), PSAT1(1) 503223 4 1 4 0 0 3 0 0 1 0 0.900 1.000 536 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(2), FUCA1(2), GNS(3), HEXB(2), HPSE2(3), LCT(5), MAN2B1(1), MANBA(1), NAGLU(1), NEU1(1), SPAM1(3) 3577556 24 7 24 9 10 8 2 0 4 0 0.902 1.000 537 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACYP1(1), GCDH(2), HADHA(1) 813961 4 2 4 2 1 1 1 0 1 0 0.903 1.000 538 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS2(1), ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ALDH7A1(2), ALDOC(2), DLAT(1), DLD(1), ENO3(1), FBP2(1), G6PC(1), G6PC2(1), GCK(1), GPI(1), HK3(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), LDHB(2), PDHA1(1), PDHA2(2), PFKM(3), PGK2(1), PGM1(2), PGM3(1) 5954183 40 10 40 18 11 17 8 0 4 0 0.904 1.000 539 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), EP300(2), NCOA1(2), NCOA2(3) 1914638 11 4 11 2 6 3 2 0 0 0 0.908 1.000 540 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 IARS(1), LARS(1), LARS2(1), PDHA1(1), PDHA2(2) 1797879 6 4 6 6 2 1 3 0 0 0 0.909 1.000 541 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), GGPS1(1), SQLE(1) 458529 3 1 3 1 0 2 1 0 0 0 0.910 1.000 542 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOC(2), DLAT(1), DLD(1), ENO3(1), FBP2(1), G6PC(1), GCK(1), GOT1(1), GPI(1), HK3(1), LDHA(1), LDHAL6B(1), LDHB(2), PC(3), PCK1(3), PDHA1(1), PDHA2(2), PFKM(3), PGK2(1) 4332244 28 8 28 17 9 12 3 0 4 0 0.910 1.000 543 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(3), CD38(1), ENPP3(1), NMNAT1(1), NMNAT2(1), NNMT(2), NNT(2), NT5E(1) 1520657 12 3 12 6 2 5 2 0 3 0 0.912 1.000 544 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(1), ACADL(2), ACADM(3), ACOX3(2), ACSL6(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), CPT1A(1), CPT2(1), CYP4A11(1), GCDH(2), HADHA(1), HADHB(1), HSD17B10(1) 5074012 28 8 28 13 5 12 4 1 6 0 0.913 1.000 545 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(7), CTCFL(1), EHMT2(2), EZH1(1), FBXO11(1), HSF4(1), MEN1(1), MLL(6), MLL2(3), MLL3(6), MLL4(3), MLL5(6), NSD1(3), OGT(1), PAXIP1(1), PPP1CB(1), PPP1CC(1), PRDM2(2), PRDM7(1), PRDM9(6), PRMT7(1), PRMT8(2), SATB1(1), SETD1A(1), SETD2(6), SETD7(1), SETDB1(1), SETDB2(2), SETMAR(1), SMYD3(2), STK38(1), SUV39H2(1), SUV420H1(3), SUZ12(1), WHSC1(1) 12525939 79 18 79 12 23 28 10 0 17 1 0.913 1.000 546 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), EP300(2), MAPK3(1) 1578558 7 3 7 2 3 3 0 0 1 0 0.914 1.000 547 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(1), AGTR1(2), AGTR2(1), COL4A1(2), COL4A2(1), COL4A3(1), COL4A4(2), COL4A5(2), REN(2) 2697611 17 5 17 5 5 8 1 0 3 0 0.915 1.000 548 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), DFFA(1), GZMB(1), SCAP(1) 1871719 12 4 12 2 3 5 1 0 3 0 0.915 1.000 549 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(1), BAIAP2(1), CASP3(1), INSR(1), MAGI1(3), MAGI2(5), WWP1(3) 2437286 15 5 15 3 5 2 5 0 3 0 0.918 1.000 550 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP6(1), CFLAR(1), CHUK(2), CRADD(1), DAXX(1), DFFA(1), LMNB1(2), MAP3K1(2), MAP3K14(1), MAP3K5(1), MAPK8(5), NFKB1(3), NUMA1(2), PAK2(1), PRKDC(5), RASA1(4), RB1(3), SPTAN1(4), TRAF1(1) 7263620 50 11 50 10 17 14 9 1 9 0 0.920 1.000 551 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT2(1), AKT3(1), BRAF(2), DAG1(1), DRD2(2), EGFR(1), EPHB2(1), GRB2(1), ITPR1(8), ITPR2(6), ITPR3(1), KCNJ5(1), KCNJ9(1), PI3(1), PLCB3(1), PLCB4(1), RAF1(2), RGS20(1), SOS1(2), SOS2(2), TERF2IP(1) 6141485 38 10 38 6 18 10 5 0 4 1 0.921 1.000 552 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPPL2(1), DHFR(1) 661507 2 2 2 0 0 2 0 0 0 0 0.922 1.000 553 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(1), DFFA(1), GZMB(1), TOP2A(3), TOP2B(4) 1080557 10 2 10 2 1 4 3 0 2 0 0.922 1.000 554 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 GOSR1(1), GOSR2(1), SEC22B(1), STX11(1), STX17(1), STX18(1), STX19(1), STX2(1), STX3(1), STX7(1), STX8(2), VAMP3(1), VAMP4(1), YKT6(1) 1695963 15 4 15 3 4 4 3 0 4 0 0.923 1.000 555 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 GAL3ST1(2), LCT(5), NEU1(1) 2451793 8 5 8 6 5 2 0 0 1 0 0.924 1.000 556 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(2), CREBBP(4), DFFA(1), GZMA(1), GZMB(1) 1111386 9 3 9 3 5 3 0 0 1 0 0.928 1.000 557 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(2), ALDH1B1(2) 830564 5 2 5 2 1 2 1 0 1 0 0.929 1.000 558 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(2), ALDH1B1(2) 830564 5 2 5 2 1 2 1 0 1 0 0.929 1.000 559 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP4(2), CASP6(1), DFFA(1), GZMB(1), LMNB1(2) 1998616 16 4 16 3 4 6 1 0 5 0 0.931 1.000 560 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN2(1), EGFR(1), MAPK3(1), MYLK(3), PRKACG(1), PRKAR1A(4), PRKAR2B(1), TLN1(2) 3452323 15 6 15 7 6 6 1 0 2 0 0.931 1.000 561 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(1), GNGT1(1), GRB2(1), IGF1R(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MKNK2(1), NGFR(1), PDGFRA(4), PTPRR(4), RAF1(2), RPS6KA5(3), SOS1(2) 3443297 24 6 24 7 7 8 7 0 1 1 0.932 1.000 562 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(4), EP300(2), NCOA3(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1) 2120312 17 4 17 4 6 8 1 0 2 0 0.939 1.000 563 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(3), CPT1A(1), CPT2(1), HADHA(1), SLC25A20(1) 1741765 9 3 9 3 2 3 1 0 3 0 0.939 1.000 564 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(1), COPS5(1), EP300(2), HIF1A(2), LDHA(1), VHL(1) 1719183 9 3 9 1 4 2 1 0 2 0 0.942 1.000 565 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 CA3(1), CA5A(1), CA8(1), CPS1(6), CTH(1), GLUL(1), HAL(1) 1950093 12 3 12 5 4 6 0 0 2 0 0.943 1.000 566 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR3(1), CCR4(1), CCR7(2), CD28(1), CXCR4(1), IFNGR1(1), IFNGR2(1), IL12A(1), IL12RB2(1), IL18R1(2), IL2(1), TGFB2(4) 2040347 17 4 17 4 4 9 2 0 2 0 0.943 1.000 567 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT2(1), AKT3(1), DAG1(1), GNAQ(1), ITPR1(8), ITPR2(6), ITPR3(1), NFKB1(3), NFKB2(2), PDK1(2), PHKA2(1), PLD1(3), PLD2(1) 4645072 32 7 32 4 14 9 1 1 6 1 0.948 1.000 568 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(2), IKBKB(2), IL2(1), MAP3K1(2), MAP3K5(1), MAPK8(5), NFKB1(3), TNFRSF9(1) 2059451 18 3 18 4 4 11 2 1 0 0 0.949 1.000 569 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), GAD1(2), HADHA(1), HMGCL(1), PDHA1(1), PDHA2(2) 2681351 13 5 13 11 5 4 2 0 2 0 0.949 1.000 570 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(2), PGAP1(2), PIGB(1), PIGG(2), PIGK(1), PIGM(2), PIGN(1), PIGO(1), PIGT(1), PIGU(1), PIGV(2), PIGX(2) 2561752 18 4 18 6 5 10 2 0 1 0 0.949 1.000 571 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), HIF1A(2), JAK2(3), NFKB1(3) 1330552 9 2 9 4 4 1 0 0 3 1 0.950 1.000 572 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1) 401481 1 1 1 1 0 1 0 0 0 0 0.952 1.000 573 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT3(1), CHST11(1), CHST12(1), CHST13(1), DSE(1), XYLT1(2) 1446504 7 3 7 3 3 3 1 0 0 0 0.953 1.000 574 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(5), APOC1(1), APOC2(1), CETP(1), HMGCR(1), LDLR(1), LIPC(1), LRP1(3), SCARB1(1) 2692048 15 5 15 5 9 4 1 0 1 0 0.954 1.000 575 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BIRC3(5) 848148 5 2 5 2 2 2 0 0 1 0 0.957 1.000 576 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 FDFT1(1), GGCX(3), GGPS1(1), HMGCR(1), LSS(1), SC4MOL(1), SC5DL(2), SQLE(1) 2019745 11 4 11 5 5 4 2 0 0 0 0.958 1.000 577 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), ALDOC(2), FBP2(1), FPGT(2), GMPPA(1), HK3(1), LHPP(1), MTMR1(1), MTMR2(1), PFKFB1(1), PFKM(3), PMM1(2), RDH11(1), RDH12(1), SORD(2) 3893809 21 7 21 7 9 10 2 0 0 0 0.958 1.000 578 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(1), GNAQ(1) 609504 2 1 2 1 0 1 0 0 1 0 0.959 1.000 579 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(5), ABCA10(3), ABCA12(11), ABCA13(17), ABCA3(1), ABCA4(4), ABCA5(2), ABCA6(5), ABCA8(7), ABCA9(6), ABCB1(5), ABCB11(3), ABCB4(3), ABCB5(4), ABCB6(1), ABCB7(1), ABCB8(1), ABCC1(3), ABCC11(2), ABCC12(4), ABCC2(3), ABCC5(2), ABCC6(2), ABCC8(1), ABCC9(4), ABCD2(1), ABCG1(1), ABCG2(4), CFTR(4), TAP1(2), TAP2(1) 12216133 113 16 113 31 29 51 17 1 14 1 0.959 1.000 580 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(2), ACADM(3), ACOX3(2), ACSL6(1), CPT1A(1), CPT2(1), CYP4A11(1), CYP8B1(1), FABP2(1), FABP7(1), FADS2(1), GK2(3), HMGCS2(1), ME1(2), MMP1(1), OLR1(1), PCK1(3), PLTP(2), PPARD(1), RXRB(1), RXRG(1), SLC27A2(1), SLC27A5(1), SLC27A6(5), SORBS1(4) 6696765 42 10 42 11 17 14 6 1 4 0 0.959 1.000 581 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP6(1), CFLAR(1), CHUK(2), DFFA(1), MAP3K14(1), NFKB1(3), SPTAN1(4), TNFRSF10B(4) 3501705 26 6 26 6 10 7 4 0 5 0 0.960 1.000 582 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGEF2(3), CLTA(1), COPA(1), GBF1(1), GPLD1(2), KDELR2(1) 1683220 9 2 9 3 4 2 1 0 2 0 0.966 1.000 583 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2D(1), DAG1(1), ITPR1(8), ITPR2(6), ITPR3(1), PDE6A(1), PDE6C(2), SLC6A13(1), TF(4) 3771123 25 6 25 1 9 11 1 0 3 1 0.967 1.000 584 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(3), EGFR(1), GRB2(1), MET(1), PDGFRA(4), PRKCA(2), SH3GLB1(1) 2027909 13 3 13 4 6 5 2 0 0 0 0.970 1.000 585 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(1), AASDHPPT(1), AASS(2), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), BBOX1(2), DLST(1), EHMT2(2), GCDH(2), HADHA(1), PLOD1(1), PLOD2(1), PLOD3(1), SHMT1(1), TMLHE(2) 3747127 23 6 23 8 7 7 4 0 5 0 0.970 1.000 586 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(1), AASS(2), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), BBOX1(2), DLST(1), EHMT2(2), GCDH(2), HADHA(1), HSD17B10(1), NSD1(3), OGDHL(3), PLOD1(1), PLOD2(1), PLOD3(1), RDH11(1), RDH12(1), SETD1A(1), SETD7(1), SETDB1(1), SHMT1(1), SPCS3(1), SUV39H2(1), TMLHE(2) 5948349 37 9 37 10 13 11 6 0 7 0 0.971 1.000 587 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 AGT(1), AGTR1(2), AGTR2(1), BDKRB2(1), KNG1(1), REN(2) 1008723 8 2 8 4 1 5 0 0 2 0 0.972 1.000 588 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(2), IKBKB(2), IL1R1(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MYD88(1), NFKB1(3), TLR4(3), TNFAIP3(1) 2516408 18 4 18 3 5 7 5 0 1 0 0.973 1.000 589 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), HLA-DRA(1), HLA-DRB1(1), IFNGR1(1), IFNGR2(1), IL12A(1), IL12RB2(1), IL18R1(2), IL2(1) 1299774 10 2 10 2 3 5 1 0 1 0 0.975 1.000 590 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 86 CHAD(1), COL11A1(6), COL11A2(1), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(1), COL4A4(2), COL5A1(2), COL5A2(3), COL5A3(5), COL6A2(1), COL6A3(12), COL6A6(5), DAG1(1), FN1(4), FNDC1(8), FNDC3A(2), GP5(1), GP6(1), HMMR(2), ITGA10(4), ITGA11(2), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAV(4), ITGB3(2), ITGB4(1), ITGB5(1), ITGB8(1), LAMA1(2), LAMA2(3), LAMA3(6), LAMA4(2), LAMB2(3), LAMB4(4), LAMC1(4), LAMC2(3), LAMC3(2), RELN(9), SDC1(1), SDC2(1), SDC3(1), SV2A(1), SV2B(2), THBS1(2), THBS2(5), THBS3(1), THBS4(1), TNC(3), TNN(2), TNR(2), TNXB(3), VTN(3), VWF(5) 23347672 163 30 163 74 56 61 20 4 21 1 0.978 1.000 591 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 PDE1A(1), PDE1B(1), PRL(1), TRH(1) 1155503 4 2 4 3 1 3 0 0 0 0 0.978 1.000 592 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 HADHA(1) 506761 1 1 1 2 0 0 0 0 1 0 0.979 1.000 593 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(2), COL4A2(1), COL4A3(1), COL4A4(2), COL4A5(2), F2(1), F5(7), F8(3), FGA(2), FGB(1), KLKB1(2), PROS1(3), SERPING1(2) 4663016 29 6 29 9 8 12 5 0 4 0 0.980 1.000 594 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(2), ACTN2(1), ACTN3(1), ITGB3(2), SPTAN1(4), TLN1(2) 3016452 13 5 13 6 6 6 0 0 1 0 0.980 1.000 595 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(1), CTH(1), GOT1(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), LDHB(2), SULT1B1(1), SULT1C2(1) 1295310 10 2 10 4 3 4 2 0 1 0 0.983 1.000 596 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), AADAC(1), ACSM1(2), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), DDHD1(2), GAD1(2), HADHA(1), HMGCL(1), HMGCS2(1), HSD17B10(1), PDHA1(1), PDHA2(2), RDH11(1), RDH12(1) 4253932 23 6 23 15 8 8 3 0 4 0 0.983 1.000 597 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 RDH11(1), RDH12(1) 500230 2 1 2 1 1 1 0 0 0 0 0.985 1.000 598 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2F1(2), NCOA1(2), NCOA2(3), NCOA3(5) 2611578 13 4 13 4 4 4 4 0 1 0 0.986 1.000 599 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), HADHA(1) 1267635 6 2 6 4 1 2 1 0 2 0 0.987 1.000 600 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 137 CHAD(1), COL11A1(6), COL11A2(1), COL17A1(2), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(1), COL4A4(2), COL5A1(2), COL5A2(3), COL5A3(5), COL6A2(1), COL6A3(12), COL6A6(5), DSC1(1), DSC3(1), DSG1(2), DSG4(4), FN1(4), GJA1(4), GJA10(4), GJA8(1), GJA9(1), GJB3(1), GJB7(1), GJC3(1), GJD2(1), ITGA6(1), ITGB4(1), KRT1(1), KRT12(1), KRT14(2), KRT15(1), KRT20(1), KRT24(2), KRT27(1), KRT3(1), KRT32(1), KRT33B(1), KRT35(2), KRT37(3), KRT38(2), KRT5(1), KRT6A(1), KRT7(2), KRT73(2), KRT74(2), KRT75(1), KRT78(1), KRT79(1), KRT82(2), KRT84(4), KRT85(1), KRT9(1), LAMA1(2), LAMA2(3), LAMA3(6), LAMA4(2), LAMB2(3), LAMB4(4), LAMC1(4), LAMC2(3), LAMC3(2), LMNB1(2), NES(1), PRPH(1), RELN(9), THBS1(2), THBS2(5), THBS3(1), THBS4(1), TNC(3), TNN(2), TNR(2), TNXB(3), VIM(1), VTN(3), VWF(5) 25514719 182 33 182 88 71 66 21 3 20 1 0.989 1.000 601 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(1), PAPSS2(2), SULT1E1(1), SULT2A1(1) 628786 5 1 5 0 0 4 1 0 0 0 0.989 1.000 602 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), OAT(1) 567042 2 1 2 1 1 0 1 0 0 0 0.990 1.000 603 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 NR3C1(1) 576879 1 1 1 1 0 0 0 0 1 0 0.990 1.000 604 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CDC40(1), CLK3(1), COL2A1(1), CPSF1(1), CPSF3(1), CPSF4(1), CSTF1(1), CSTF2T(2), CSTF3(2), DDX20(1), DHX15(2), DHX38(1), DHX9(1), DICER1(1), LSM2(1), METTL3(1), NCBP1(2), NONO(1), NXF1(2), PAPOLA(1), PRPF18(1), PRPF4B(6), PRPF8(2), PTBP2(1), RBM5(2), RNMT(1), RNPS1(1), SF3A1(1), SF3B1(1), SNRPA(1), SNRPB(1), SNRPD3(1), SRPK1(2), SRPK2(2), SRRM1(3), SUPT5H(1), U2AF1(1), U2AF2(1), XRN2(2) 10899539 56 14 56 13 16 23 11 0 6 0 0.991 1.000 605 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD58(1), IL6(1), IL8(1) 658336 3 1 3 2 1 1 1 0 0 0 0.992 1.000 606 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1), NR1H4(1) 555480 2 1 2 0 2 0 0 0 0 0 0.993 1.000 607 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(1), CREBBP(4), DLL1(3), DLL3(1), DLL4(1), DTX2(1), DTX3(1), DVL2(1), DVL3(2), EP300(2), JAG1(1), MAML1(2), NOTCH2(2), NOTCH3(3), NOTCH4(4), PTCRA(1), RBPJ(4), SNW1(1) 6970229 35 9 35 12 14 11 4 0 6 0 0.997 1.000 608 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(2), CREBBP(4), EP300(2), IKBKB(2), NFKB1(3) 2308900 13 2 13 4 6 6 1 0 0 0 0.997 1.000 609 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL10(1), IL12A(1), IL16(4), IL2(1), IL6(1), IL8(1), IL9(1) 1002307 10 1 10 5 2 7 0 0 1 0 0.999 1.000 610 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 IL8(1), NFKB1(3) 1026866 4 1 4 2 3 1 0 0 0 0 1.000 1.000 611 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2D3(1), UBE2I(1), UBE3A(5) 1083070 8 1 8 0 2 4 2 0 0 0 1.000 1.000 612 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(1), CREBBP(4), EP300(2), ERCC3(1), GRIP1(1), GTF2F1(2), HDAC5(1), HDAC6(2), MEF2C(2), NR0B1(1), NRIP1(1) 4918334 18 4 18 8 7 10 1 0 0 0 1.000 1.000 613 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(1), MBTPS1(3), SCAP(1) 1218484 5 1 5 2 3 2 0 0 0 0 1.000 1.000 614 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGFR(1), MAP2K1(1), MAP3K1(2) 1792067 4 1 4 2 1 2 1 0 0 0 1.000 1.000 615 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 52302 0 0 0 0 0 0 0 0 0 0 1.000 1.000 616 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 119779 0 0 0 0 0 0 0 0 0 0 1.000 1.000